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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ABLIM3-TRPM8 (FusionGDB2 ID:HG22885TG79054)

Fusion Gene Summary for ABLIM3-TRPM8

check button Fusion gene summary
Fusion gene informationFusion gene name: ABLIM3-TRPM8
Fusion gene ID: hg22885tg79054
HgeneTgene
Gene symbol

ABLIM3

TRPM8

Gene ID

22885

79054

Gene nameactin binding LIM protein family member 3transient receptor potential cation channel subfamily M member 8
SynonymsHMFN1661LTRPC6|LTrpC-6|TRPP8|trp-p8
Cytomap('ABLIM3')('TRPM8')

5q32

2q37.1

Type of geneprotein-codingprotein-coding
Descriptionactin-binding LIM protein 3abLIM-3transient receptor potential cation channel subfamily M member 8TRPM8 cationic channeltransient receptor potential p8transient receptor potential subfamily M member 8
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000309868, ENST00000326685, 
ENST00000356541, ENST00000504238, 
ENST00000506113, ENST00000508983, 
ENST00000517451, ENST00000519549, 
Fusion gene scores* DoF score4 X 4 X 3=487 X 7 X 4=196
# samples 47
** MAII scorelog2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(7/196*10)=-1.48542682717024
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ABLIM3 [Title/Abstract] AND TRPM8 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointABLIM3(148521671)-TRPM8(234835178), # samples:3
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID


check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4CESCTCGA-HM-A3JJ-01AABLIM3chr5

148521671

-TRPM8chr2

234835178

+
ChimerDB4CESCTCGA-HM-A3JJ-01AABLIM3chr5

148521671

+TRPM8chr2

234835178

+


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Fusion Gene ORF analysis for ABLIM3-TRPM8

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000309868ENST00000324695ABLIM3chr5

148521671

+TRPM8chr2

234835178

+
5CDS-5UTRENST00000309868ENST00000433712ABLIM3chr5

148521671

+TRPM8chr2

234835178

+
5CDS-5UTRENST00000326685ENST00000324695ABLIM3chr5

148521671

+TRPM8chr2

234835178

+
5CDS-5UTRENST00000326685ENST00000433712ABLIM3chr5

148521671

+TRPM8chr2

234835178

+
5CDS-5UTRENST00000356541ENST00000324695ABLIM3chr5

148521671

+TRPM8chr2

234835178

+
5CDS-5UTRENST00000356541ENST00000433712ABLIM3chr5

148521671

+TRPM8chr2

234835178

+
5CDS-5UTRENST00000504238ENST00000324695ABLIM3chr5

148521671

+TRPM8chr2

234835178

+
5CDS-5UTRENST00000504238ENST00000433712ABLIM3chr5

148521671

+TRPM8chr2

234835178

+
5CDS-5UTRENST00000506113ENST00000324695ABLIM3chr5

148521671

+TRPM8chr2

234835178

+
5CDS-5UTRENST00000506113ENST00000433712ABLIM3chr5

148521671

+TRPM8chr2

234835178

+
5CDS-5UTRENST00000508983ENST00000324695ABLIM3chr5

148521671

+TRPM8chr2

234835178

+
5CDS-5UTRENST00000508983ENST00000433712ABLIM3chr5

148521671

+TRPM8chr2

234835178

+
5CDS-intronENST00000309868ENST00000355722ABLIM3chr5

148521671

+TRPM8chr2

234835178

+
5CDS-intronENST00000309868ENST00000409625ABLIM3chr5

148521671

+TRPM8chr2

234835178

+
5CDS-intronENST00000309868ENST00000466594ABLIM3chr5

148521671

+TRPM8chr2

234835178

+
5CDS-intronENST00000326685ENST00000355722ABLIM3chr5

148521671

+TRPM8chr2

234835178

+
5CDS-intronENST00000326685ENST00000409625ABLIM3chr5

148521671

+TRPM8chr2

234835178

+
5CDS-intronENST00000326685ENST00000466594ABLIM3chr5

148521671

+TRPM8chr2

234835178

+
5CDS-intronENST00000356541ENST00000355722ABLIM3chr5

148521671

+TRPM8chr2

234835178

+
5CDS-intronENST00000356541ENST00000409625ABLIM3chr5

148521671

+TRPM8chr2

234835178

+
5CDS-intronENST00000356541ENST00000466594ABLIM3chr5

148521671

+TRPM8chr2

234835178

+
5CDS-intronENST00000504238ENST00000355722ABLIM3chr5

148521671

+TRPM8chr2

234835178

+
5CDS-intronENST00000504238ENST00000409625ABLIM3chr5

148521671

+TRPM8chr2

234835178

+
5CDS-intronENST00000504238ENST00000466594ABLIM3chr5

148521671

+TRPM8chr2

234835178

+
5CDS-intronENST00000506113ENST00000355722ABLIM3chr5

148521671

+TRPM8chr2

234835178

+
5CDS-intronENST00000506113ENST00000409625ABLIM3chr5

148521671

+TRPM8chr2

234835178

+
5CDS-intronENST00000506113ENST00000466594ABLIM3chr5

148521671

+TRPM8chr2

234835178

+
5CDS-intronENST00000508983ENST00000355722ABLIM3chr5

148521671

+TRPM8chr2

234835178

+
5CDS-intronENST00000508983ENST00000409625ABLIM3chr5

148521671

+TRPM8chr2

234835178

+
5CDS-intronENST00000508983ENST00000466594ABLIM3chr5

148521671

+TRPM8chr2

234835178

+
intron-5UTRENST00000517451ENST00000324695ABLIM3chr5

148521671

+TRPM8chr2

234835178

+
intron-5UTRENST00000517451ENST00000433712ABLIM3chr5

148521671

+TRPM8chr2

234835178

+
intron-5UTRENST00000519549ENST00000324695ABLIM3chr5

148521671

+TRPM8chr2

234835178

+
intron-5UTRENST00000519549ENST00000433712ABLIM3chr5

148521671

+TRPM8chr2

234835178

+
intron-intronENST00000517451ENST00000355722ABLIM3chr5

148521671

+TRPM8chr2

234835178

+
intron-intronENST00000517451ENST00000409625ABLIM3chr5

148521671

+TRPM8chr2

234835178

+
intron-intronENST00000517451ENST00000466594ABLIM3chr5

148521671

+TRPM8chr2

234835178

+
intron-intronENST00000519549ENST00000355722ABLIM3chr5

148521671

+TRPM8chr2

234835178

+
intron-intronENST00000519549ENST00000409625ABLIM3chr5

148521671

+TRPM8chr2

234835178

+
intron-intronENST00000519549ENST00000466594ABLIM3chr5

148521671

+TRPM8chr2

234835178

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for ABLIM3-TRPM8


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
ABLIM3chr5148521671+TRPM8chr2234835177+0.404993240.59500676
ABLIM3chr5148521671+TRPM8chr2234835177+0.404993240.59500676


check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for ABLIM3-TRPM8


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:148521671/:234835178)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for ABLIM3-TRPM8


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for ABLIM3-TRPM8


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ABLIM3-TRPM8


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ABLIM3-TRPM8


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneABLIM3C0023893Liver Cirrhosis, Experimental1CTD_human
TgeneC0007852Cervical Migraine Syndrome1CTD_human
TgeneC0018984Hemicrania migraine1CTD_human
TgeneC0149931Migraine Disorders1CTD_human
TgeneC0270858Abdominal Migraine1CTD_human
TgeneC0338480Common Migraine1CTD_human
TgeneC0338489Status Migrainosus1CTD_human
TgeneC0521664Acute Confusional Migraine1CTD_human
TgeneC0700438Sick Headaches1CTD_human