|
||||||
|
 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:CARD8-RPA1 (FusionGDB2 ID:HG22900TG6117) |
Fusion Gene Summary for CARD8-RPA1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: CARD8-RPA1 | Fusion gene ID: hg22900tg6117 | Hgene | Tgene | Gene symbol | CARD8 | RPA1 | Gene ID | 22900 | 6117 |
| Gene name | caspase recruitment domain family member 8 | replication protein A1 | |
| Synonyms | CARDINAL|DACAR|DAKAR|NDPP|NDPP1|TUCAN | HSSB|MST075|REPA1|RF-A|RP-A|RPA70 | |
| Cytomap | ('CARD8')('RPA1') 19q13.33 | 17p13.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | caspase recruitment domain-containing protein 8CARD inhibitor of NF-kappaB-activating ligandsapoptotic protein NDPP1tumor up-regulated CARD-containing antagonist of CASP9tumor up-regulated CARD-containing antagonist of caspase nine | replication protein A 70 kDa DNA-binding subunitMSTP075RF-A protein 1RP-A p70replication factor A protein 1replication protein A1, 70kDasingle-stranded DNA-binding protein | |
| Modification date | 20200320 | 20200322 | |
| UniProtAcc | . | . | |
| Ensembl transtripts involved in fusion gene | ENST00000391898, ENST00000447740, ENST00000519332, ENST00000519940, ENST00000520007, ENST00000520015, ENST00000520153, ENST00000520753, ENST00000521613, ENST00000522431, ENST00000357778, ENST00000359009, ENST00000600800, | ||
| Fusion gene scores | * DoF score | 12 X 16 X 6=1152 | 9 X 8 X 3=216 |
| # samples | 14 | 9 | |
| ** MAII score | log2(14/1152*10)=-3.04064198449735 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(9/216*10)=-1.26303440583379 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: CARD8 [Title/Abstract] AND RPA1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | CARD8(48744218)-RPA1(1746096), # samples:1 | ||
| Anticipated loss of major functional domain due to fusion event. | CARD8-RPA1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. CARD8-RPA1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. CARD8-RPA1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. CARD8-RPA1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. CARD8-RPA1 seems lost the major protein functional domain in Tgene partner, which is a tumor suppressor due to the frame-shifted ORF. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | CARD8 | GO:0031665 | negative regulation of lipopolysaccharide-mediated signaling pathway | 11821383 |
| Hgene | CARD8 | GO:0043124 | negative regulation of I-kappaB kinase/NF-kappaB signaling | 11551959 |
| Hgene | CARD8 | GO:0043280 | positive regulation of cysteine-type endopeptidase activity involved in apoptotic process | 11821383|15030775 |
| Hgene | CARD8 | GO:0050713 | negative regulation of interleukin-1 beta secretion | 11821383 |
| Hgene | CARD8 | GO:0050718 | positive regulation of interleukin-1 beta secretion | 15030775 |
| Hgene | CARD8 | GO:0097340 | inhibition of cysteine-type endopeptidase activity | 11821383 |
| Tgene | RPA1 | GO:0006284 | base-excision repair | 9765279 |
| Tgene | RPA1 | GO:0034502 | protein localization to chromosome | 27723717|27723720 |
| Fusion gene breakpoints across CARD8 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
 |
| Fusion gene breakpoints across RPA1 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
 |
| Fusion gene information * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Top |
Fusion Gene ORF analysis for CARD8-RPA1 |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000391898 | ENST00000254719 | CARD8 | chr19 | 48744218 | - | RPA1 | chr17 | 1746096 | + | 0.001859083 | 0.99814093 |
| ENST00000447740 | ENST00000254719 | CARD8 | chr19 | 48744218 | - | RPA1 | chr17 | 1746096 | + | 0.002203841 | 0.9977962 |
| ENST00000520153 | ENST00000254719 | CARD8 | chr19 | 48744218 | - | RPA1 | chr17 | 1746096 | + | 0.002127725 | 0.99787223 |
| ENST00000520015 | ENST00000254719 | CARD8 | chr19 | 48744218 | - | RPA1 | chr17 | 1746096 | + | 0.002192939 | 0.9978071 |
| ENST00000522431 | ENST00000254719 | CARD8 | chr19 | 48744218 | - | RPA1 | chr17 | 1746096 | + | 0.001832901 | 0.99816704 |
Top |
Fusion Genomic Features for CARD8-RPA1 |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| CARD8 | chr19 | 48744218 | - | RPA1 | chr17 | 1746096 | + | 0.000436573 | 0.9995634 |
| CARD8 | chr19 | 48744218 | - | RPA1 | chr17 | 1746096 | + | 0.000436573 | 0.9995634 |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
 |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
 |
Top |
Fusion Protein Features for CARD8-RPA1 |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:48744218/chr17:1746096) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| . | . |
| FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. | FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | RPA1 | chr19:48744218 | chr17:1746096 | ENST00000254719 | 0 | 17 | 197_281 | 11 | 617.0 | DNA binding | Note=OB | |
| Tgene | RPA1 | chr19:48744218 | chr17:1746096 | ENST00000254719 | 0 | 17 | 481_503 | 11 | 617.0 | Zinc finger | C4-type |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | CARD8 | chr19:48744218 | chr17:1746096 | ENST00000359009 | - | 2 | 10 | 340_430 | 0 | 432.0 | Domain | CARD |
| Hgene | CARD8 | chr19:48744218 | chr17:1746096 | ENST00000359009 | - | 2 | 10 | 56_340 | 0 | 432.0 | Domain | FIIND |
| Hgene | CARD8 | chr19:48744218 | chr17:1746096 | ENST00000391898 | - | 1 | 11 | 340_430 | 19 | 538.0 | Domain | CARD |
| Hgene | CARD8 | chr19:48744218 | chr17:1746096 | ENST00000391898 | - | 1 | 11 | 56_340 | 19 | 538.0 | Domain | FIIND |
| Hgene | CARD8 | chr19:48744218 | chr17:1746096 | ENST00000447740 | - | 2 | 11 | 340_430 | 19 | 488.0 | Domain | CARD |
| Hgene | CARD8 | chr19:48744218 | chr17:1746096 | ENST00000447740 | - | 2 | 11 | 56_340 | 19 | 488.0 | Domain | FIIND |
| Hgene | CARD8 | chr19:48744218 | chr17:1746096 | ENST00000519940 | - | 4 | 14 | 340_430 | 19 | 538.0 | Domain | CARD |
| Hgene | CARD8 | chr19:48744218 | chr17:1746096 | ENST00000519940 | - | 4 | 14 | 56_340 | 19 | 538.0 | Domain | FIIND |
| Hgene | CARD8 | chr19:48744218 | chr17:1746096 | ENST00000520015 | - | 2 | 11 | 340_430 | 19 | 546.0 | Domain | CARD |
| Hgene | CARD8 | chr19:48744218 | chr17:1746096 | ENST00000520015 | - | 2 | 11 | 56_340 | 19 | 546.0 | Domain | FIIND |
| Hgene | CARD8 | chr19:48744218 | chr17:1746096 | ENST00000520153 | - | 3 | 12 | 340_430 | 19 | 488.0 | Domain | CARD |
| Hgene | CARD8 | chr19:48744218 | chr17:1746096 | ENST00000520153 | - | 3 | 12 | 56_340 | 19 | 488.0 | Domain | FIIND |
| Hgene | CARD8 | chr19:48744218 | chr17:1746096 | ENST00000520753 | - | 4 | 13 | 340_430 | 19 | 840.3333333333334 | Domain | CARD |
| Hgene | CARD8 | chr19:48744218 | chr17:1746096 | ENST00000520753 | - | 4 | 13 | 56_340 | 19 | 840.3333333333334 | Domain | FIIND |
| Hgene | CARD8 | chr19:48744218 | chr17:1746096 | ENST00000521613 | - | 3 | 12 | 340_430 | 19 | 488.0 | Domain | CARD |
| Hgene | CARD8 | chr19:48744218 | chr17:1746096 | ENST00000521613 | - | 3 | 12 | 56_340 | 19 | 488.0 | Domain | FIIND |
Top |
Fusion Gene Sequence for CARD8-RPA1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >13040_13040_1_CARD8-RPA1_CARD8_chr19_48744218_ENST00000391898_RPA1_chr17_1746096_ENST00000254719_length(transcript)=4299nt_BP=102nt GGTAAAAAAGATACAGTAAAGACATAAATACCACATTTGACAAATGGAAAAAAAGGAGTGTCCAGAAAAGAGTAGCAGCAGTGAGGAAGA GCTGCCGAGACGGCCATCATGCAGAAGGGGGATACAAACATAAAGCCCATCCTCCAAGTCATCAACATCCGTCCCATTACTACGGGGAAT AGTCCGCCGCGTTATCGACTGCTCATGAGTGATGGATTGAACACTCTATCCTCTTTCATGTTGGCGACACAGTTGAACCCTCTCGTGGAG GAAGAACAATTGTCCAGCAACTGTGTATGCCAGATTCACAGATTTATTGTGAACACTCTGAAAGACGGAAGGAGAGTAGTTATCTTGATG GAATTAGAAGTTTTGAAGTCAGCTGAAGCAGTTGGAGTGAAGATTGGCAATCCAGTGCCCTATAATGAAGGACTCGGGCAGCCGCAAGTA GCTCCTCCAGCGCCAGCAGCCAGCCCAGCAGCAAGCAGCAGGCCCCAGCCGCAGAATGGAAGCTCGGGAATGGGTTCTACTGTTTCTAAG GCTTATGGTGCTTCAAAGACATTTGGAAAAGCTGCAGGTCCCAGCCTGTCACACACTTCTGGGGGAACACAGTCCAAAGTGGTGCCCATT GCCAGCCTCACTCCTTACCAGTCCAAGTGGACCATTTGTGCTCGTGTTACCAACAAAAGTCAGATCCGTACCTGGAGCAACTCCCGAGGG GAAGGGAAGCTTTTCTCCCTAGAACTGGTTGACGAAAGTGGTGAAATCCGAGCTACAGCTTTCAATGAGCAAGTGGACAAGTTCTTTCCT CTTATTGAAGTGAACAAGGTGTATTATTTCTCGAAAGGCACCCTGAAGATTGCTAACAAGCAGTTCACAGCTGTTAAAAATGACTACGAG ATGACCTTCAATAACGAGACTTCCGTCATGCCCTGTGAGGACGACCATCATTTACCTACGGTTCAGTTTGATTTCACGGGGATTGATGAC CTCGAGAACAAGTCGAAAGACTCACTTGTAGACATCATCGGGATCTGCAAGAGCTATGAAGACGCCACTAAAATCACAGTGAGGTCTAAC AACAGAGAAGTTGCCAAGAGGAATATCTACTTGATGGACACATCCGGGAAGGTGGTGACTGCTACACTGTGGGGGGAAGATGCTGATAAA TTTGATGGTTCTAGACAGCCCGTGTTGGCTATCAAAGGAGCCCGAGTCTCTGATTTCGGTGGACGGAGCCTCTCCGTGCTGTCTTCAAGC ACTATCATTGCGAATCCTGACATCCCAGAGGCCTATAAGCTTCGTGGATGGTTTGACGCAGAAGGACAAGCCTTAGATGGTGTTTCCATC TCTGATCTAAAGAGCGGCGGAGTCGGAGGGAGTAACACCAACTGGAAAACCTTGTATGAGGTCAAATCCGAGAACCTGGGCCAAGGCGAC AAGCCGGACTACTTTAGTTCTGTGGCCACAGTGGTGTATCTTCGCAAAGAGAACTGCATGTACCAAGCCTGCCCGACTCAGGACTGCAAT AAGAAAGTGATTGATCAACAGAATGGATTGTACCGCTGTGAGAAGTGCGACACCGAATTTCCCAATTTCAAGTACCGCATGATCCTGTCA GTAAATATTGCAGATTTTCAAGAGAATCAGTGGGTGACTTGTTTCCAGGAGTCTGCTGAAGCTATCCTTGGACAAAATGCTGCTTATCTT GGGGAATTAAAAGACAAGAATGAACAGGCATTTGAAGAAGTTTTCCAGAATGCCAACTTCCGATCTTTCATATTCAGAGTCAGGGTCAAA GTGGAGACCTACAACGACGAGTCTCGAATTAAGGCCACTGTGATGGACGTGAAGCCCGTGGACTACAGAGAGTATGGCCGAAGGCTGGTC ATGAGCATCAGGAGAAGTGCATTGATGTGAGAGGAGCAGTGCCAATCGGGCAGAAGTTTGCAAATAGGCAGAATGGAATCGATTTCCTCC CACCTCCGTGTGACGATCCCATGTTAGCTACACAGTGCAGAGGCTCTTGATGGTGGACTAAGCAATTTCCCCCCTCGTGCGCATCTCAGA ACCCATCGGTAGGCAAAGGAAAATACGCTCAGGTGGTTGTGGTGTAGACTGTGTCAGGCCTACGGAGTCAGCCAGTGGCTAGCGCAAGAC CAGTCACTCCCTCTGCCTTCAGGCTTCTGTCAATTTCATTATCATCAAGCAGGAATTATGTCGTAAGTCACTGACCCTAACTGCAGACCA TGAAGTAAATTATGTAACTAGGTTTTTGCTTCTCCAGTGGTGACCACCCCCCCCCATCCCCGCTCACAACTTGGGTTCTTCTCAGCGGGG CGAGCTGAGAAGCGGTCATGAGCACCTGGGGATTTTAGTAAGTGTGTCTTCCTAGAATTCGAAGGCTCTCTCTTTCTAGAGGTGCTACAT AGTTGGTAATGCTTGGAATGGCAATAGGGTAGAATGATTAATCAAAGGCATATCTTCTATATCTGAAGAGTATCCTTCCTTCAGGGTTTA ATAGACTGAGTCAGATGGGTCTGATATTAATCAAAATTGTCTCTTCTGAGGACCGCTGATAAGCATTGACTTGCCGTCCCCTAAGGAAAT CCGAGCGGCTACAAAGCGTTTCTTTACTTCTCACTTCAATTAATGCTGCGCTTCGCTTGGTGAGTGCGTACTTTTTCTACCTGTACACAT TCCTGCATTCATGTATTTTGTTTTTTTTGACTAAAGCTATGTTACATGGAAAGGATTTTGAAGCCTTTTGTTTCCCTTGCTTTGTTTTAA TAAACAGTATATTCTTTGGTTGTGAATCCTACTTTCTTTGAATGCAAAGAGTTCCTATAACTGGAAAGCAATTAATTAGCCTTCATAATA AATGTTCACTTGGGGGGGATGTTAACTCATTATAAACCCGAAGATTAGTCCAAGGCATGGAGATCCTTCTTCCTAGTGTTTGCAGCCCTG AAATGCATCTTTCAAAGCATGAAAACACTAAAAACAAAAAGCCATTTTGCCTGAGGATGCTGATGATCTGGCACTTGGGATTTTATTGAT GTTTACGCAGCAGTCTAACACCAACCACGCTTTGAAATGTGTACAGACAGTGAGCTGGTAAGAAAACAGTAATTATGCTAGTGGGCCTTT CAGTCAGCAAAAGCATGCTCGCTCTGTGTGTTCCTAATCATATTAATTATCTATCCGGTGGCTGCAACACACCGCCTGCCATTGGCCGCA CATCTCGCCGTCGTACCCCGGCAGTGCGGCGGTCACTCTGCAGCCAGAGGACCTGCTGTTCATCACTGCACATGCCGCCTGCGGAGGCTT TTGGATATGGGGAGTGATGGTGTCCTGTCTGTCTCCCCCCTCGGTGTCTGCCGTTGACATAGGGGCCAGCCAGCCCTAGACGGGATGACT TCCGTTCCTGAGGACAGACACAGAGGGACTCCTGCTCAGCCTCACTAATTGTTTAGACACATTCCTTCCTACCCTTCTCTAGTCTCAGGA GATGGTAACTGGGTCGCATTTCAGTCTCTGACTGAGGCCTCAGCCATTTTTACGGAAGTTCTTTTCTGTCTGACCTTGCTTATAAAGCAT CGACGAGAAAATTACAGTCTTCAACCCTCTTCTGGATTGACAAATTGTGGCTGGGAAGTGGCGATCTAGCTTTCAGCCCAGTAACCAGTC TTTCATGCCTACTACTCCCAGCATTCCCTCCTCTCCCCACGTGTCTGTCCACACAGTGAAGAGGCCTGACCAGCCGTGGTACCAGGACAG GACGTGTCCAGGGAACGCTGACACCTGTCCTCGCGCCTTCTCAGTGGCCAGCGTGATGAAACCAGCACGTCTCCGTGGATGTGATTGGGA ACCCAGGGGCAGTGCCAGGGGGAGGGCTCCCTCGAGGAGGCTGTTTCTAACAGATTTCCCCACTCAAAGATCAGATCACCAGCAGAGGAG CATCAGAAACTGGCTCCACTGTTGGGCTTTTCAGAGATTTTGGTCCCTGCGGGTTGCCTAAATAGATTCTGGCCCACAGTTTACCTCGAA AGGCTGTTGATGTTGTTCTGTTTCTCCTCTTTCACTTAGAGATCAATGTTGATTTTGCGTACACCATGACATCAGCGTTAGGCAATTAGG AGAAAAAAATCTAATCATTTCGCCTTTATTTCAAGTGGTTCTTGAATTCCCTCCAGTCTCATTGTGAAAGGGGCAGGGAAAAAAATAAAA >13040_13040_1_CARD8-RPA1_CARD8_chr19_48744218_ENST00000391898_RPA1_chr17_1746096_ENST00000254719_length(amino acids)=603AA_BP=0 MQKGDTNIKPILQVINIRPITTGNSPPRYRLLMSDGLNTLSSFMLATQLNPLVEEEQLSSNCVCQIHRFIVNTLKDGRRVVILMELEVLK SAEAVGVKIGNPVPYNEGLGQPQVAPPAPAASPAASSRPQPQNGSSGMGSTVSKAYGASKTFGKAAGPSLSHTSGGTQSKVVPIASLTPY QSKWTICARVTNKSQIRTWSNSRGEGKLFSLELVDESGEIRATAFNEQVDKFFPLIEVNKVYYFSKGTLKIANKQFTAVKNDYEMTFNNE TSVMPCEDDHHLPTVQFDFTGIDDLENKSKDSLVDIIGICKSYEDATKITVRSNNREVAKRNIYLMDTSGKVVTATLWGEDADKFDGSRQ PVLAIKGARVSDFGGRSLSVLSSSTIIANPDIPEAYKLRGWFDAEGQALDGVSISDLKSGGVGGSNTNWKTLYEVKSENLGQGDKPDYFS SVATVVYLRKENCMYQACPTQDCNKKVIDQQNGLYRCEKCDTEFPNFKYRMILSVNIADFQENQWVTCFQESAEAILGQNAAYLGELKDK -------------------------------------------------------------- >13040_13040_2_CARD8-RPA1_CARD8_chr19_48744218_ENST00000447740_RPA1_chr17_1746096_ENST00000254719_length(transcript)=4396nt_BP=199nt TGACCAAGAGGAACAGAACACAGAGCAGCCTGGCAGTGTCCAAGCAACAAGCCTCCGCTCCTCCTTCCTGCACCCTGGGGCTCCTGAAAC TCACATGGGTAAAAAAGATACAGTAAAGACATAAATACCACATTTGACAAATGGAAAAAAAGGAGTGTCCAGAAAAGAGTAGCAGCAGTG AGGAAGAGCTGCCGAGACGGCCATCATGCAGAAGGGGGATACAAACATAAAGCCCATCCTCCAAGTCATCAACATCCGTCCCATTACTAC GGGGAATAGTCCGCCGCGTTATCGACTGCTCATGAGTGATGGATTGAACACTCTATCCTCTTTCATGTTGGCGACACAGTTGAACCCTCT CGTGGAGGAAGAACAATTGTCCAGCAACTGTGTATGCCAGATTCACAGATTTATTGTGAACACTCTGAAAGACGGAAGGAGAGTAGTTAT CTTGATGGAATTAGAAGTTTTGAAGTCAGCTGAAGCAGTTGGAGTGAAGATTGGCAATCCAGTGCCCTATAATGAAGGACTCGGGCAGCC GCAAGTAGCTCCTCCAGCGCCAGCAGCCAGCCCAGCAGCAAGCAGCAGGCCCCAGCCGCAGAATGGAAGCTCGGGAATGGGTTCTACTGT TTCTAAGGCTTATGGTGCTTCAAAGACATTTGGAAAAGCTGCAGGTCCCAGCCTGTCACACACTTCTGGGGGAACACAGTCCAAAGTGGT GCCCATTGCCAGCCTCACTCCTTACCAGTCCAAGTGGACCATTTGTGCTCGTGTTACCAACAAAAGTCAGATCCGTACCTGGAGCAACTC CCGAGGGGAAGGGAAGCTTTTCTCCCTAGAACTGGTTGACGAAAGTGGTGAAATCCGAGCTACAGCTTTCAATGAGCAAGTGGACAAGTT CTTTCCTCTTATTGAAGTGAACAAGGTGTATTATTTCTCGAAAGGCACCCTGAAGATTGCTAACAAGCAGTTCACAGCTGTTAAAAATGA CTACGAGATGACCTTCAATAACGAGACTTCCGTCATGCCCTGTGAGGACGACCATCATTTACCTACGGTTCAGTTTGATTTCACGGGGAT TGATGACCTCGAGAACAAGTCGAAAGACTCACTTGTAGACATCATCGGGATCTGCAAGAGCTATGAAGACGCCACTAAAATCACAGTGAG GTCTAACAACAGAGAAGTTGCCAAGAGGAATATCTACTTGATGGACACATCCGGGAAGGTGGTGACTGCTACACTGTGGGGGGAAGATGC TGATAAATTTGATGGTTCTAGACAGCCCGTGTTGGCTATCAAAGGAGCCCGAGTCTCTGATTTCGGTGGACGGAGCCTCTCCGTGCTGTC TTCAAGCACTATCATTGCGAATCCTGACATCCCAGAGGCCTATAAGCTTCGTGGATGGTTTGACGCAGAAGGACAAGCCTTAGATGGTGT TTCCATCTCTGATCTAAAGAGCGGCGGAGTCGGAGGGAGTAACACCAACTGGAAAACCTTGTATGAGGTCAAATCCGAGAACCTGGGCCA AGGCGACAAGCCGGACTACTTTAGTTCTGTGGCCACAGTGGTGTATCTTCGCAAAGAGAACTGCATGTACCAAGCCTGCCCGACTCAGGA CTGCAATAAGAAAGTGATTGATCAACAGAATGGATTGTACCGCTGTGAGAAGTGCGACACCGAATTTCCCAATTTCAAGTACCGCATGAT CCTGTCAGTAAATATTGCAGATTTTCAAGAGAATCAGTGGGTGACTTGTTTCCAGGAGTCTGCTGAAGCTATCCTTGGACAAAATGCTGC TTATCTTGGGGAATTAAAAGACAAGAATGAACAGGCATTTGAAGAAGTTTTCCAGAATGCCAACTTCCGATCTTTCATATTCAGAGTCAG GGTCAAAGTGGAGACCTACAACGACGAGTCTCGAATTAAGGCCACTGTGATGGACGTGAAGCCCGTGGACTACAGAGAGTATGGCCGAAG GCTGGTCATGAGCATCAGGAGAAGTGCATTGATGTGAGAGGAGCAGTGCCAATCGGGCAGAAGTTTGCAAATAGGCAGAATGGAATCGAT TTCCTCCCACCTCCGTGTGACGATCCCATGTTAGCTACACAGTGCAGAGGCTCTTGATGGTGGACTAAGCAATTTCCCCCCTCGTGCGCA TCTCAGAACCCATCGGTAGGCAAAGGAAAATACGCTCAGGTGGTTGTGGTGTAGACTGTGTCAGGCCTACGGAGTCAGCCAGTGGCTAGC GCAAGACCAGTCACTCCCTCTGCCTTCAGGCTTCTGTCAATTTCATTATCATCAAGCAGGAATTATGTCGTAAGTCACTGACCCTAACTG CAGACCATGAAGTAAATTATGTAACTAGGTTTTTGCTTCTCCAGTGGTGACCACCCCCCCCCATCCCCGCTCACAACTTGGGTTCTTCTC AGCGGGGCGAGCTGAGAAGCGGTCATGAGCACCTGGGGATTTTAGTAAGTGTGTCTTCCTAGAATTCGAAGGCTCTCTCTTTCTAGAGGT GCTACATAGTTGGTAATGCTTGGAATGGCAATAGGGTAGAATGATTAATCAAAGGCATATCTTCTATATCTGAAGAGTATCCTTCCTTCA GGGTTTAATAGACTGAGTCAGATGGGTCTGATATTAATCAAAATTGTCTCTTCTGAGGACCGCTGATAAGCATTGACTTGCCGTCCCCTA AGGAAATCCGAGCGGCTACAAAGCGTTTCTTTACTTCTCACTTCAATTAATGCTGCGCTTCGCTTGGTGAGTGCGTACTTTTTCTACCTG TACACATTCCTGCATTCATGTATTTTGTTTTTTTTGACTAAAGCTATGTTACATGGAAAGGATTTTGAAGCCTTTTGTTTCCCTTGCTTT GTTTTAATAAACAGTATATTCTTTGGTTGTGAATCCTACTTTCTTTGAATGCAAAGAGTTCCTATAACTGGAAAGCAATTAATTAGCCTT CATAATAAATGTTCACTTGGGGGGGATGTTAACTCATTATAAACCCGAAGATTAGTCCAAGGCATGGAGATCCTTCTTCCTAGTGTTTGC AGCCCTGAAATGCATCTTTCAAAGCATGAAAACACTAAAAACAAAAAGCCATTTTGCCTGAGGATGCTGATGATCTGGCACTTGGGATTT TATTGATGTTTACGCAGCAGTCTAACACCAACCACGCTTTGAAATGTGTACAGACAGTGAGCTGGTAAGAAAACAGTAATTATGCTAGTG GGCCTTTCAGTCAGCAAAAGCATGCTCGCTCTGTGTGTTCCTAATCATATTAATTATCTATCCGGTGGCTGCAACACACCGCCTGCCATT GGCCGCACATCTCGCCGTCGTACCCCGGCAGTGCGGCGGTCACTCTGCAGCCAGAGGACCTGCTGTTCATCACTGCACATGCCGCCTGCG GAGGCTTTTGGATATGGGGAGTGATGGTGTCCTGTCTGTCTCCCCCCTCGGTGTCTGCCGTTGACATAGGGGCCAGCCAGCCCTAGACGG GATGACTTCCGTTCCTGAGGACAGACACAGAGGGACTCCTGCTCAGCCTCACTAATTGTTTAGACACATTCCTTCCTACCCTTCTCTAGT CTCAGGAGATGGTAACTGGGTCGCATTTCAGTCTCTGACTGAGGCCTCAGCCATTTTTACGGAAGTTCTTTTCTGTCTGACCTTGCTTAT AAAGCATCGACGAGAAAATTACAGTCTTCAACCCTCTTCTGGATTGACAAATTGTGGCTGGGAAGTGGCGATCTAGCTTTCAGCCCAGTA ACCAGTCTTTCATGCCTACTACTCCCAGCATTCCCTCCTCTCCCCACGTGTCTGTCCACACAGTGAAGAGGCCTGACCAGCCGTGGTACC AGGACAGGACGTGTCCAGGGAACGCTGACACCTGTCCTCGCGCCTTCTCAGTGGCCAGCGTGATGAAACCAGCACGTCTCCGTGGATGTG ATTGGGAACCCAGGGGCAGTGCCAGGGGGAGGGCTCCCTCGAGGAGGCTGTTTCTAACAGATTTCCCCACTCAAAGATCAGATCACCAGC AGAGGAGCATCAGAAACTGGCTCCACTGTTGGGCTTTTCAGAGATTTTGGTCCCTGCGGGTTGCCTAAATAGATTCTGGCCCACAGTTTA CCTCGAAAGGCTGTTGATGTTGTTCTGTTTCTCCTCTTTCACTTAGAGATCAATGTTGATTTTGCGTACACCATGACATCAGCGTTAGGC AATTAGGAGAAAAAAATCTAATCATTTCGCCTTTATTTCAAGTGGTTCTTGAATTCCCTCCAGTCTCATTGTGAAAGGGGCAGGGAAAAA >13040_13040_2_CARD8-RPA1_CARD8_chr19_48744218_ENST00000447740_RPA1_chr17_1746096_ENST00000254719_length(amino acids)=603AA_BP=0 MQKGDTNIKPILQVINIRPITTGNSPPRYRLLMSDGLNTLSSFMLATQLNPLVEEEQLSSNCVCQIHRFIVNTLKDGRRVVILMELEVLK SAEAVGVKIGNPVPYNEGLGQPQVAPPAPAASPAASSRPQPQNGSSGMGSTVSKAYGASKTFGKAAGPSLSHTSGGTQSKVVPIASLTPY QSKWTICARVTNKSQIRTWSNSRGEGKLFSLELVDESGEIRATAFNEQVDKFFPLIEVNKVYYFSKGTLKIANKQFTAVKNDYEMTFNNE TSVMPCEDDHHLPTVQFDFTGIDDLENKSKDSLVDIIGICKSYEDATKITVRSNNREVAKRNIYLMDTSGKVVTATLWGEDADKFDGSRQ PVLAIKGARVSDFGGRSLSVLSSSTIIANPDIPEAYKLRGWFDAEGQALDGVSISDLKSGGVGGSNTNWKTLYEVKSENLGQGDKPDYFS SVATVVYLRKENCMYQACPTQDCNKKVIDQQNGLYRCEKCDTEFPNFKYRMILSVNIADFQENQWVTCFQESAEAILGQNAAYLGELKDK -------------------------------------------------------------- >13040_13040_3_CARD8-RPA1_CARD8_chr19_48744218_ENST00000520015_RPA1_chr17_1746096_ENST00000254719_length(transcript)=4382nt_BP=185nt AGAACACAGAGCAGCCTGGCAGTGTCCAAGCAACAAGCCTCCGCTCCTCCTTCCTGCACCCTGGGGCTCCTGAAACTCACATGGGTAAAA AAGATACAGTAAAGACATAAATACCACATTTGACAAATGGAAAAAAAGGAGTGTCCAGAAAAGAGTAGCAGCAGTGAGGAAGAGCTGCCG AGACGGCCATCATGCAGAAGGGGGATACAAACATAAAGCCCATCCTCCAAGTCATCAACATCCGTCCCATTACTACGGGGAATAGTCCGC CGCGTTATCGACTGCTCATGAGTGATGGATTGAACACTCTATCCTCTTTCATGTTGGCGACACAGTTGAACCCTCTCGTGGAGGAAGAAC AATTGTCCAGCAACTGTGTATGCCAGATTCACAGATTTATTGTGAACACTCTGAAAGACGGAAGGAGAGTAGTTATCTTGATGGAATTAG AAGTTTTGAAGTCAGCTGAAGCAGTTGGAGTGAAGATTGGCAATCCAGTGCCCTATAATGAAGGACTCGGGCAGCCGCAAGTAGCTCCTC CAGCGCCAGCAGCCAGCCCAGCAGCAAGCAGCAGGCCCCAGCCGCAGAATGGAAGCTCGGGAATGGGTTCTACTGTTTCTAAGGCTTATG GTGCTTCAAAGACATTTGGAAAAGCTGCAGGTCCCAGCCTGTCACACACTTCTGGGGGAACACAGTCCAAAGTGGTGCCCATTGCCAGCC TCACTCCTTACCAGTCCAAGTGGACCATTTGTGCTCGTGTTACCAACAAAAGTCAGATCCGTACCTGGAGCAACTCCCGAGGGGAAGGGA AGCTTTTCTCCCTAGAACTGGTTGACGAAAGTGGTGAAATCCGAGCTACAGCTTTCAATGAGCAAGTGGACAAGTTCTTTCCTCTTATTG AAGTGAACAAGGTGTATTATTTCTCGAAAGGCACCCTGAAGATTGCTAACAAGCAGTTCACAGCTGTTAAAAATGACTACGAGATGACCT TCAATAACGAGACTTCCGTCATGCCCTGTGAGGACGACCATCATTTACCTACGGTTCAGTTTGATTTCACGGGGATTGATGACCTCGAGA ACAAGTCGAAAGACTCACTTGTAGACATCATCGGGATCTGCAAGAGCTATGAAGACGCCACTAAAATCACAGTGAGGTCTAACAACAGAG AAGTTGCCAAGAGGAATATCTACTTGATGGACACATCCGGGAAGGTGGTGACTGCTACACTGTGGGGGGAAGATGCTGATAAATTTGATG GTTCTAGACAGCCCGTGTTGGCTATCAAAGGAGCCCGAGTCTCTGATTTCGGTGGACGGAGCCTCTCCGTGCTGTCTTCAAGCACTATCA TTGCGAATCCTGACATCCCAGAGGCCTATAAGCTTCGTGGATGGTTTGACGCAGAAGGACAAGCCTTAGATGGTGTTTCCATCTCTGATC TAAAGAGCGGCGGAGTCGGAGGGAGTAACACCAACTGGAAAACCTTGTATGAGGTCAAATCCGAGAACCTGGGCCAAGGCGACAAGCCGG ACTACTTTAGTTCTGTGGCCACAGTGGTGTATCTTCGCAAAGAGAACTGCATGTACCAAGCCTGCCCGACTCAGGACTGCAATAAGAAAG TGATTGATCAACAGAATGGATTGTACCGCTGTGAGAAGTGCGACACCGAATTTCCCAATTTCAAGTACCGCATGATCCTGTCAGTAAATA TTGCAGATTTTCAAGAGAATCAGTGGGTGACTTGTTTCCAGGAGTCTGCTGAAGCTATCCTTGGACAAAATGCTGCTTATCTTGGGGAAT TAAAAGACAAGAATGAACAGGCATTTGAAGAAGTTTTCCAGAATGCCAACTTCCGATCTTTCATATTCAGAGTCAGGGTCAAAGTGGAGA CCTACAACGACGAGTCTCGAATTAAGGCCACTGTGATGGACGTGAAGCCCGTGGACTACAGAGAGTATGGCCGAAGGCTGGTCATGAGCA TCAGGAGAAGTGCATTGATGTGAGAGGAGCAGTGCCAATCGGGCAGAAGTTTGCAAATAGGCAGAATGGAATCGATTTCCTCCCACCTCC GTGTGACGATCCCATGTTAGCTACACAGTGCAGAGGCTCTTGATGGTGGACTAAGCAATTTCCCCCCTCGTGCGCATCTCAGAACCCATC GGTAGGCAAAGGAAAATACGCTCAGGTGGTTGTGGTGTAGACTGTGTCAGGCCTACGGAGTCAGCCAGTGGCTAGCGCAAGACCAGTCAC TCCCTCTGCCTTCAGGCTTCTGTCAATTTCATTATCATCAAGCAGGAATTATGTCGTAAGTCACTGACCCTAACTGCAGACCATGAAGTA AATTATGTAACTAGGTTTTTGCTTCTCCAGTGGTGACCACCCCCCCCCATCCCCGCTCACAACTTGGGTTCTTCTCAGCGGGGCGAGCTG AGAAGCGGTCATGAGCACCTGGGGATTTTAGTAAGTGTGTCTTCCTAGAATTCGAAGGCTCTCTCTTTCTAGAGGTGCTACATAGTTGGT AATGCTTGGAATGGCAATAGGGTAGAATGATTAATCAAAGGCATATCTTCTATATCTGAAGAGTATCCTTCCTTCAGGGTTTAATAGACT GAGTCAGATGGGTCTGATATTAATCAAAATTGTCTCTTCTGAGGACCGCTGATAAGCATTGACTTGCCGTCCCCTAAGGAAATCCGAGCG GCTACAAAGCGTTTCTTTACTTCTCACTTCAATTAATGCTGCGCTTCGCTTGGTGAGTGCGTACTTTTTCTACCTGTACACATTCCTGCA TTCATGTATTTTGTTTTTTTTGACTAAAGCTATGTTACATGGAAAGGATTTTGAAGCCTTTTGTTTCCCTTGCTTTGTTTTAATAAACAG TATATTCTTTGGTTGTGAATCCTACTTTCTTTGAATGCAAAGAGTTCCTATAACTGGAAAGCAATTAATTAGCCTTCATAATAAATGTTC ACTTGGGGGGGATGTTAACTCATTATAAACCCGAAGATTAGTCCAAGGCATGGAGATCCTTCTTCCTAGTGTTTGCAGCCCTGAAATGCA TCTTTCAAAGCATGAAAACACTAAAAACAAAAAGCCATTTTGCCTGAGGATGCTGATGATCTGGCACTTGGGATTTTATTGATGTTTACG CAGCAGTCTAACACCAACCACGCTTTGAAATGTGTACAGACAGTGAGCTGGTAAGAAAACAGTAATTATGCTAGTGGGCCTTTCAGTCAG CAAAAGCATGCTCGCTCTGTGTGTTCCTAATCATATTAATTATCTATCCGGTGGCTGCAACACACCGCCTGCCATTGGCCGCACATCTCG CCGTCGTACCCCGGCAGTGCGGCGGTCACTCTGCAGCCAGAGGACCTGCTGTTCATCACTGCACATGCCGCCTGCGGAGGCTTTTGGATA TGGGGAGTGATGGTGTCCTGTCTGTCTCCCCCCTCGGTGTCTGCCGTTGACATAGGGGCCAGCCAGCCCTAGACGGGATGACTTCCGTTC CTGAGGACAGACACAGAGGGACTCCTGCTCAGCCTCACTAATTGTTTAGACACATTCCTTCCTACCCTTCTCTAGTCTCAGGAGATGGTA ACTGGGTCGCATTTCAGTCTCTGACTGAGGCCTCAGCCATTTTTACGGAAGTTCTTTTCTGTCTGACCTTGCTTATAAAGCATCGACGAG AAAATTACAGTCTTCAACCCTCTTCTGGATTGACAAATTGTGGCTGGGAAGTGGCGATCTAGCTTTCAGCCCAGTAACCAGTCTTTCATG CCTACTACTCCCAGCATTCCCTCCTCTCCCCACGTGTCTGTCCACACAGTGAAGAGGCCTGACCAGCCGTGGTACCAGGACAGGACGTGT CCAGGGAACGCTGACACCTGTCCTCGCGCCTTCTCAGTGGCCAGCGTGATGAAACCAGCACGTCTCCGTGGATGTGATTGGGAACCCAGG GGCAGTGCCAGGGGGAGGGCTCCCTCGAGGAGGCTGTTTCTAACAGATTTCCCCACTCAAAGATCAGATCACCAGCAGAGGAGCATCAGA AACTGGCTCCACTGTTGGGCTTTTCAGAGATTTTGGTCCCTGCGGGTTGCCTAAATAGATTCTGGCCCACAGTTTACCTCGAAAGGCTGT TGATGTTGTTCTGTTTCTCCTCTTTCACTTAGAGATCAATGTTGATTTTGCGTACACCATGACATCAGCGTTAGGCAATTAGGAGAAAAA AATCTAATCATTTCGCCTTTATTTCAAGTGGTTCTTGAATTCCCTCCAGTCTCATTGTGAAAGGGGCAGGGAAAAAAATAAAAGGGTAAT >13040_13040_3_CARD8-RPA1_CARD8_chr19_48744218_ENST00000520015_RPA1_chr17_1746096_ENST00000254719_length(amino acids)=603AA_BP=0 MQKGDTNIKPILQVINIRPITTGNSPPRYRLLMSDGLNTLSSFMLATQLNPLVEEEQLSSNCVCQIHRFIVNTLKDGRRVVILMELEVLK SAEAVGVKIGNPVPYNEGLGQPQVAPPAPAASPAASSRPQPQNGSSGMGSTVSKAYGASKTFGKAAGPSLSHTSGGTQSKVVPIASLTPY QSKWTICARVTNKSQIRTWSNSRGEGKLFSLELVDESGEIRATAFNEQVDKFFPLIEVNKVYYFSKGTLKIANKQFTAVKNDYEMTFNNE TSVMPCEDDHHLPTVQFDFTGIDDLENKSKDSLVDIIGICKSYEDATKITVRSNNREVAKRNIYLMDTSGKVVTATLWGEDADKFDGSRQ PVLAIKGARVSDFGGRSLSVLSSSTIIANPDIPEAYKLRGWFDAEGQALDGVSISDLKSGGVGGSNTNWKTLYEVKSENLGQGDKPDYFS SVATVVYLRKENCMYQACPTQDCNKKVIDQQNGLYRCEKCDTEFPNFKYRMILSVNIADFQENQWVTCFQESAEAILGQNAAYLGELKDK -------------------------------------------------------------- >13040_13040_4_CARD8-RPA1_CARD8_chr19_48744218_ENST00000520153_RPA1_chr17_1746096_ENST00000254719_length(transcript)=4486nt_BP=289nt AGAGCAGCCTGGCAGTGTCCAAGCAACAAGCCTCCGCTCCTCCTTCCTGCACCCTGGGGCTCCTGAAACTCACATGAGAAGGAGGGCTGT CTGAGATTCGAGGGAAACAAGCTCTCAGGACTTCCGGTCGCCATGATGGCTGTGGGCGGTAAACGCGGTTAGTGCAAGCATCTGGGCCAT CTTCAATGGTAAAAAAGATACAGTAAAGACATAAATACCACATTTGACAAATGGAAAAAAAGGAGTGTCCAGAAAAGAGTAGCAGCAGTG AGGAAGAGCTGCCGAGACGGCCATCATGCAGAAGGGGGATACAAACATAAAGCCCATCCTCCAAGTCATCAACATCCGTCCCATTACTAC GGGGAATAGTCCGCCGCGTTATCGACTGCTCATGAGTGATGGATTGAACACTCTATCCTCTTTCATGTTGGCGACACAGTTGAACCCTCT CGTGGAGGAAGAACAATTGTCCAGCAACTGTGTATGCCAGATTCACAGATTTATTGTGAACACTCTGAAAGACGGAAGGAGAGTAGTTAT CTTGATGGAATTAGAAGTTTTGAAGTCAGCTGAAGCAGTTGGAGTGAAGATTGGCAATCCAGTGCCCTATAATGAAGGACTCGGGCAGCC GCAAGTAGCTCCTCCAGCGCCAGCAGCCAGCCCAGCAGCAAGCAGCAGGCCCCAGCCGCAGAATGGAAGCTCGGGAATGGGTTCTACTGT TTCTAAGGCTTATGGTGCTTCAAAGACATTTGGAAAAGCTGCAGGTCCCAGCCTGTCACACACTTCTGGGGGAACACAGTCCAAAGTGGT GCCCATTGCCAGCCTCACTCCTTACCAGTCCAAGTGGACCATTTGTGCTCGTGTTACCAACAAAAGTCAGATCCGTACCTGGAGCAACTC CCGAGGGGAAGGGAAGCTTTTCTCCCTAGAACTGGTTGACGAAAGTGGTGAAATCCGAGCTACAGCTTTCAATGAGCAAGTGGACAAGTT CTTTCCTCTTATTGAAGTGAACAAGGTGTATTATTTCTCGAAAGGCACCCTGAAGATTGCTAACAAGCAGTTCACAGCTGTTAAAAATGA CTACGAGATGACCTTCAATAACGAGACTTCCGTCATGCCCTGTGAGGACGACCATCATTTACCTACGGTTCAGTTTGATTTCACGGGGAT TGATGACCTCGAGAACAAGTCGAAAGACTCACTTGTAGACATCATCGGGATCTGCAAGAGCTATGAAGACGCCACTAAAATCACAGTGAG GTCTAACAACAGAGAAGTTGCCAAGAGGAATATCTACTTGATGGACACATCCGGGAAGGTGGTGACTGCTACACTGTGGGGGGAAGATGC TGATAAATTTGATGGTTCTAGACAGCCCGTGTTGGCTATCAAAGGAGCCCGAGTCTCTGATTTCGGTGGACGGAGCCTCTCCGTGCTGTC TTCAAGCACTATCATTGCGAATCCTGACATCCCAGAGGCCTATAAGCTTCGTGGATGGTTTGACGCAGAAGGACAAGCCTTAGATGGTGT TTCCATCTCTGATCTAAAGAGCGGCGGAGTCGGAGGGAGTAACACCAACTGGAAAACCTTGTATGAGGTCAAATCCGAGAACCTGGGCCA AGGCGACAAGCCGGACTACTTTAGTTCTGTGGCCACAGTGGTGTATCTTCGCAAAGAGAACTGCATGTACCAAGCCTGCCCGACTCAGGA CTGCAATAAGAAAGTGATTGATCAACAGAATGGATTGTACCGCTGTGAGAAGTGCGACACCGAATTTCCCAATTTCAAGTACCGCATGAT CCTGTCAGTAAATATTGCAGATTTTCAAGAGAATCAGTGGGTGACTTGTTTCCAGGAGTCTGCTGAAGCTATCCTTGGACAAAATGCTGC TTATCTTGGGGAATTAAAAGACAAGAATGAACAGGCATTTGAAGAAGTTTTCCAGAATGCCAACTTCCGATCTTTCATATTCAGAGTCAG GGTCAAAGTGGAGACCTACAACGACGAGTCTCGAATTAAGGCCACTGTGATGGACGTGAAGCCCGTGGACTACAGAGAGTATGGCCGAAG GCTGGTCATGAGCATCAGGAGAAGTGCATTGATGTGAGAGGAGCAGTGCCAATCGGGCAGAAGTTTGCAAATAGGCAGAATGGAATCGAT TTCCTCCCACCTCCGTGTGACGATCCCATGTTAGCTACACAGTGCAGAGGCTCTTGATGGTGGACTAAGCAATTTCCCCCCTCGTGCGCA TCTCAGAACCCATCGGTAGGCAAAGGAAAATACGCTCAGGTGGTTGTGGTGTAGACTGTGTCAGGCCTACGGAGTCAGCCAGTGGCTAGC GCAAGACCAGTCACTCCCTCTGCCTTCAGGCTTCTGTCAATTTCATTATCATCAAGCAGGAATTATGTCGTAAGTCACTGACCCTAACTG CAGACCATGAAGTAAATTATGTAACTAGGTTTTTGCTTCTCCAGTGGTGACCACCCCCCCCCATCCCCGCTCACAACTTGGGTTCTTCTC AGCGGGGCGAGCTGAGAAGCGGTCATGAGCACCTGGGGATTTTAGTAAGTGTGTCTTCCTAGAATTCGAAGGCTCTCTCTTTCTAGAGGT GCTACATAGTTGGTAATGCTTGGAATGGCAATAGGGTAGAATGATTAATCAAAGGCATATCTTCTATATCTGAAGAGTATCCTTCCTTCA GGGTTTAATAGACTGAGTCAGATGGGTCTGATATTAATCAAAATTGTCTCTTCTGAGGACCGCTGATAAGCATTGACTTGCCGTCCCCTA AGGAAATCCGAGCGGCTACAAAGCGTTTCTTTACTTCTCACTTCAATTAATGCTGCGCTTCGCTTGGTGAGTGCGTACTTTTTCTACCTG TACACATTCCTGCATTCATGTATTTTGTTTTTTTTGACTAAAGCTATGTTACATGGAAAGGATTTTGAAGCCTTTTGTTTCCCTTGCTTT GTTTTAATAAACAGTATATTCTTTGGTTGTGAATCCTACTTTCTTTGAATGCAAAGAGTTCCTATAACTGGAAAGCAATTAATTAGCCTT CATAATAAATGTTCACTTGGGGGGGATGTTAACTCATTATAAACCCGAAGATTAGTCCAAGGCATGGAGATCCTTCTTCCTAGTGTTTGC AGCCCTGAAATGCATCTTTCAAAGCATGAAAACACTAAAAACAAAAAGCCATTTTGCCTGAGGATGCTGATGATCTGGCACTTGGGATTT TATTGATGTTTACGCAGCAGTCTAACACCAACCACGCTTTGAAATGTGTACAGACAGTGAGCTGGTAAGAAAACAGTAATTATGCTAGTG GGCCTTTCAGTCAGCAAAAGCATGCTCGCTCTGTGTGTTCCTAATCATATTAATTATCTATCCGGTGGCTGCAACACACCGCCTGCCATT GGCCGCACATCTCGCCGTCGTACCCCGGCAGTGCGGCGGTCACTCTGCAGCCAGAGGACCTGCTGTTCATCACTGCACATGCCGCCTGCG GAGGCTTTTGGATATGGGGAGTGATGGTGTCCTGTCTGTCTCCCCCCTCGGTGTCTGCCGTTGACATAGGGGCCAGCCAGCCCTAGACGG GATGACTTCCGTTCCTGAGGACAGACACAGAGGGACTCCTGCTCAGCCTCACTAATTGTTTAGACACATTCCTTCCTACCCTTCTCTAGT CTCAGGAGATGGTAACTGGGTCGCATTTCAGTCTCTGACTGAGGCCTCAGCCATTTTTACGGAAGTTCTTTTCTGTCTGACCTTGCTTAT AAAGCATCGACGAGAAAATTACAGTCTTCAACCCTCTTCTGGATTGACAAATTGTGGCTGGGAAGTGGCGATCTAGCTTTCAGCCCAGTA ACCAGTCTTTCATGCCTACTACTCCCAGCATTCCCTCCTCTCCCCACGTGTCTGTCCACACAGTGAAGAGGCCTGACCAGCCGTGGTACC AGGACAGGACGTGTCCAGGGAACGCTGACACCTGTCCTCGCGCCTTCTCAGTGGCCAGCGTGATGAAACCAGCACGTCTCCGTGGATGTG ATTGGGAACCCAGGGGCAGTGCCAGGGGGAGGGCTCCCTCGAGGAGGCTGTTTCTAACAGATTTCCCCACTCAAAGATCAGATCACCAGC AGAGGAGCATCAGAAACTGGCTCCACTGTTGGGCTTTTCAGAGATTTTGGTCCCTGCGGGTTGCCTAAATAGATTCTGGCCCACAGTTTA CCTCGAAAGGCTGTTGATGTTGTTCTGTTTCTCCTCTTTCACTTAGAGATCAATGTTGATTTTGCGTACACCATGACATCAGCGTTAGGC AATTAGGAGAAAAAAATCTAATCATTTCGCCTTTATTTCAAGTGGTTCTTGAATTCCCTCCAGTCTCATTGTGAAAGGGGCAGGGAAAAA >13040_13040_4_CARD8-RPA1_CARD8_chr19_48744218_ENST00000520153_RPA1_chr17_1746096_ENST00000254719_length(amino acids)=603AA_BP=0 MQKGDTNIKPILQVINIRPITTGNSPPRYRLLMSDGLNTLSSFMLATQLNPLVEEEQLSSNCVCQIHRFIVNTLKDGRRVVILMELEVLK SAEAVGVKIGNPVPYNEGLGQPQVAPPAPAASPAASSRPQPQNGSSGMGSTVSKAYGASKTFGKAAGPSLSHTSGGTQSKVVPIASLTPY QSKWTICARVTNKSQIRTWSNSRGEGKLFSLELVDESGEIRATAFNEQVDKFFPLIEVNKVYYFSKGTLKIANKQFTAVKNDYEMTFNNE TSVMPCEDDHHLPTVQFDFTGIDDLENKSKDSLVDIIGICKSYEDATKITVRSNNREVAKRNIYLMDTSGKVVTATLWGEDADKFDGSRQ PVLAIKGARVSDFGGRSLSVLSSSTIIANPDIPEAYKLRGWFDAEGQALDGVSISDLKSGGVGGSNTNWKTLYEVKSENLGQGDKPDYFS SVATVVYLRKENCMYQACPTQDCNKKVIDQQNGLYRCEKCDTEFPNFKYRMILSVNIADFQENQWVTCFQESAEAILGQNAAYLGELKDK -------------------------------------------------------------- >13040_13040_5_CARD8-RPA1_CARD8_chr19_48744218_ENST00000522431_RPA1_chr17_1746096_ENST00000254719_length(transcript)=4548nt_BP=351nt GGGGCTCCTGAAACTCACATGGTAAGCGCTGCAGAAACGCAGCAGGTGGTGACTTTAGGGGAGGACAGGCCAAATGGGAGAATCCCCTTA AGCTTCGGTTTCTCTAGTTCTCAACTTCTTTTGAAATAATGTTCATAGAGAAGGAGGGCTGTCTGAGATTCGAGGGAAACAAGCTCTCAG GACTTCCGGTCGCCATGATGGCTGTGGGCGGTAAACGCGGTTAGTGCAAGCATCTGGGCCATCTTCAATGGTAAAAAAGATACAGTAAAG ACATAAATACCACATTTGACAAATGGAAAAAAAGGAGTGTCCAGAAAAGAGTAGCAGCAGTGAGGAAGAGCTGCCGAGACGGCCATCATG CAGAAGGGGGATACAAACATAAAGCCCATCCTCCAAGTCATCAACATCCGTCCCATTACTACGGGGAATAGTCCGCCGCGTTATCGACTG CTCATGAGTGATGGATTGAACACTCTATCCTCTTTCATGTTGGCGACACAGTTGAACCCTCTCGTGGAGGAAGAACAATTGTCCAGCAAC TGTGTATGCCAGATTCACAGATTTATTGTGAACACTCTGAAAGACGGAAGGAGAGTAGTTATCTTGATGGAATTAGAAGTTTTGAAGTCA GCTGAAGCAGTTGGAGTGAAGATTGGCAATCCAGTGCCCTATAATGAAGGACTCGGGCAGCCGCAAGTAGCTCCTCCAGCGCCAGCAGCC AGCCCAGCAGCAAGCAGCAGGCCCCAGCCGCAGAATGGAAGCTCGGGAATGGGTTCTACTGTTTCTAAGGCTTATGGTGCTTCAAAGACA TTTGGAAAAGCTGCAGGTCCCAGCCTGTCACACACTTCTGGGGGAACACAGTCCAAAGTGGTGCCCATTGCCAGCCTCACTCCTTACCAG TCCAAGTGGACCATTTGTGCTCGTGTTACCAACAAAAGTCAGATCCGTACCTGGAGCAACTCCCGAGGGGAAGGGAAGCTTTTCTCCCTA GAACTGGTTGACGAAAGTGGTGAAATCCGAGCTACAGCTTTCAATGAGCAAGTGGACAAGTTCTTTCCTCTTATTGAAGTGAACAAGGTG TATTATTTCTCGAAAGGCACCCTGAAGATTGCTAACAAGCAGTTCACAGCTGTTAAAAATGACTACGAGATGACCTTCAATAACGAGACT TCCGTCATGCCCTGTGAGGACGACCATCATTTACCTACGGTTCAGTTTGATTTCACGGGGATTGATGACCTCGAGAACAAGTCGAAAGAC TCACTTGTAGACATCATCGGGATCTGCAAGAGCTATGAAGACGCCACTAAAATCACAGTGAGGTCTAACAACAGAGAAGTTGCCAAGAGG AATATCTACTTGATGGACACATCCGGGAAGGTGGTGACTGCTACACTGTGGGGGGAAGATGCTGATAAATTTGATGGTTCTAGACAGCCC GTGTTGGCTATCAAAGGAGCCCGAGTCTCTGATTTCGGTGGACGGAGCCTCTCCGTGCTGTCTTCAAGCACTATCATTGCGAATCCTGAC ATCCCAGAGGCCTATAAGCTTCGTGGATGGTTTGACGCAGAAGGACAAGCCTTAGATGGTGTTTCCATCTCTGATCTAAAGAGCGGCGGA GTCGGAGGGAGTAACACCAACTGGAAAACCTTGTATGAGGTCAAATCCGAGAACCTGGGCCAAGGCGACAAGCCGGACTACTTTAGTTCT GTGGCCACAGTGGTGTATCTTCGCAAAGAGAACTGCATGTACCAAGCCTGCCCGACTCAGGACTGCAATAAGAAAGTGATTGATCAACAG AATGGATTGTACCGCTGTGAGAAGTGCGACACCGAATTTCCCAATTTCAAGTACCGCATGATCCTGTCAGTAAATATTGCAGATTTTCAA GAGAATCAGTGGGTGACTTGTTTCCAGGAGTCTGCTGAAGCTATCCTTGGACAAAATGCTGCTTATCTTGGGGAATTAAAAGACAAGAAT GAACAGGCATTTGAAGAAGTTTTCCAGAATGCCAACTTCCGATCTTTCATATTCAGAGTCAGGGTCAAAGTGGAGACCTACAACGACGAG TCTCGAATTAAGGCCACTGTGATGGACGTGAAGCCCGTGGACTACAGAGAGTATGGCCGAAGGCTGGTCATGAGCATCAGGAGAAGTGCA TTGATGTGAGAGGAGCAGTGCCAATCGGGCAGAAGTTTGCAAATAGGCAGAATGGAATCGATTTCCTCCCACCTCCGTGTGACGATCCCA TGTTAGCTACACAGTGCAGAGGCTCTTGATGGTGGACTAAGCAATTTCCCCCCTCGTGCGCATCTCAGAACCCATCGGTAGGCAAAGGAA AATACGCTCAGGTGGTTGTGGTGTAGACTGTGTCAGGCCTACGGAGTCAGCCAGTGGCTAGCGCAAGACCAGTCACTCCCTCTGCCTTCA GGCTTCTGTCAATTTCATTATCATCAAGCAGGAATTATGTCGTAAGTCACTGACCCTAACTGCAGACCATGAAGTAAATTATGTAACTAG GTTTTTGCTTCTCCAGTGGTGACCACCCCCCCCCATCCCCGCTCACAACTTGGGTTCTTCTCAGCGGGGCGAGCTGAGAAGCGGTCATGA GCACCTGGGGATTTTAGTAAGTGTGTCTTCCTAGAATTCGAAGGCTCTCTCTTTCTAGAGGTGCTACATAGTTGGTAATGCTTGGAATGG CAATAGGGTAGAATGATTAATCAAAGGCATATCTTCTATATCTGAAGAGTATCCTTCCTTCAGGGTTTAATAGACTGAGTCAGATGGGTC TGATATTAATCAAAATTGTCTCTTCTGAGGACCGCTGATAAGCATTGACTTGCCGTCCCCTAAGGAAATCCGAGCGGCTACAAAGCGTTT CTTTACTTCTCACTTCAATTAATGCTGCGCTTCGCTTGGTGAGTGCGTACTTTTTCTACCTGTACACATTCCTGCATTCATGTATTTTGT TTTTTTTGACTAAAGCTATGTTACATGGAAAGGATTTTGAAGCCTTTTGTTTCCCTTGCTTTGTTTTAATAAACAGTATATTCTTTGGTT GTGAATCCTACTTTCTTTGAATGCAAAGAGTTCCTATAACTGGAAAGCAATTAATTAGCCTTCATAATAAATGTTCACTTGGGGGGGATG TTAACTCATTATAAACCCGAAGATTAGTCCAAGGCATGGAGATCCTTCTTCCTAGTGTTTGCAGCCCTGAAATGCATCTTTCAAAGCATG AAAACACTAAAAACAAAAAGCCATTTTGCCTGAGGATGCTGATGATCTGGCACTTGGGATTTTATTGATGTTTACGCAGCAGTCTAACAC CAACCACGCTTTGAAATGTGTACAGACAGTGAGCTGGTAAGAAAACAGTAATTATGCTAGTGGGCCTTTCAGTCAGCAAAAGCATGCTCG CTCTGTGTGTTCCTAATCATATTAATTATCTATCCGGTGGCTGCAACACACCGCCTGCCATTGGCCGCACATCTCGCCGTCGTACCCCGG CAGTGCGGCGGTCACTCTGCAGCCAGAGGACCTGCTGTTCATCACTGCACATGCCGCCTGCGGAGGCTTTTGGATATGGGGAGTGATGGT GTCCTGTCTGTCTCCCCCCTCGGTGTCTGCCGTTGACATAGGGGCCAGCCAGCCCTAGACGGGATGACTTCCGTTCCTGAGGACAGACAC AGAGGGACTCCTGCTCAGCCTCACTAATTGTTTAGACACATTCCTTCCTACCCTTCTCTAGTCTCAGGAGATGGTAACTGGGTCGCATTT CAGTCTCTGACTGAGGCCTCAGCCATTTTTACGGAAGTTCTTTTCTGTCTGACCTTGCTTATAAAGCATCGACGAGAAAATTACAGTCTT CAACCCTCTTCTGGATTGACAAATTGTGGCTGGGAAGTGGCGATCTAGCTTTCAGCCCAGTAACCAGTCTTTCATGCCTACTACTCCCAG CATTCCCTCCTCTCCCCACGTGTCTGTCCACACAGTGAAGAGGCCTGACCAGCCGTGGTACCAGGACAGGACGTGTCCAGGGAACGCTGA CACCTGTCCTCGCGCCTTCTCAGTGGCCAGCGTGATGAAACCAGCACGTCTCCGTGGATGTGATTGGGAACCCAGGGGCAGTGCCAGGGG GAGGGCTCCCTCGAGGAGGCTGTTTCTAACAGATTTCCCCACTCAAAGATCAGATCACCAGCAGAGGAGCATCAGAAACTGGCTCCACTG TTGGGCTTTTCAGAGATTTTGGTCCCTGCGGGTTGCCTAAATAGATTCTGGCCCACAGTTTACCTCGAAAGGCTGTTGATGTTGTTCTGT TTCTCCTCTTTCACTTAGAGATCAATGTTGATTTTGCGTACACCATGACATCAGCGTTAGGCAATTAGGAGAAAAAAATCTAATCATTTC GCCTTTATTTCAAGTGGTTCTTGAATTCCCTCCAGTCTCATTGTGAAAGGGGCAGGGAAAAAAATAAAAGGGTAATAATCTGATTTCTGT >13040_13040_5_CARD8-RPA1_CARD8_chr19_48744218_ENST00000522431_RPA1_chr17_1746096_ENST00000254719_length(amino acids)=603AA_BP=0 MQKGDTNIKPILQVINIRPITTGNSPPRYRLLMSDGLNTLSSFMLATQLNPLVEEEQLSSNCVCQIHRFIVNTLKDGRRVVILMELEVLK SAEAVGVKIGNPVPYNEGLGQPQVAPPAPAASPAASSRPQPQNGSSGMGSTVSKAYGASKTFGKAAGPSLSHTSGGTQSKVVPIASLTPY QSKWTICARVTNKSQIRTWSNSRGEGKLFSLELVDESGEIRATAFNEQVDKFFPLIEVNKVYYFSKGTLKIANKQFTAVKNDYEMTFNNE TSVMPCEDDHHLPTVQFDFTGIDDLENKSKDSLVDIIGICKSYEDATKITVRSNNREVAKRNIYLMDTSGKVVTATLWGEDADKFDGSRQ PVLAIKGARVSDFGGRSLSVLSSSTIIANPDIPEAYKLRGWFDAEGQALDGVSISDLKSGGVGGSNTNWKTLYEVKSENLGQGDKPDYFS SVATVVYLRKENCMYQACPTQDCNKKVIDQQNGLYRCEKCDTEFPNFKYRMILSVNIADFQENQWVTCFQESAEAILGQNAAYLGELKDK -------------------------------------------------------------- |
Top |
Fusion Gene PPI Analysis for CARD8-RPA1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
Related Drugs for CARD8-RPA1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
Related Diseases for CARD8-RPA1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | CARD8 | C0018099 | Gout | 1 | CTD_human |
| Hgene | CARD8 | C0028797 | Occupational Diseases | 1 | CTD_human |
| Hgene | CARD8 | C0032226 | Pleural Diseases | 1 | CTD_human |
| Tgene | C0263454 | Chloracne | 1 | CTD_human |
Copyright 2021-Present -The University of Texas Health Science Center at Houston (UTHealth)
Web File Viewing | Emergency Information |Campus Carry|Site Policies