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in Kim Lab

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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:AKR7A3-CAPZB (FusionGDB2 ID:HG22977TG832)

Fusion Gene Summary for AKR7A3-CAPZB

check button Fusion gene summary
Fusion gene informationFusion gene name: AKR7A3-CAPZB
Fusion gene ID: hg22977tg832
HgeneTgene
Gene symbol

AKR7A3

CAPZB

Gene ID

22977

832

Gene namealdo-keto reductase family 7 member A3capping actin protein of muscle Z-line subunit beta
SynonymsAFAR2CAPB|CAPPB|CAPZ
Cytomap('AKR7A3')('CAPZB')

1p36.13

1p36.13

Type of geneprotein-codingprotein-coding
Descriptionaflatoxin B1 aldehyde reductase member 3AFB1 aldehyde reductase 2AFB1-AR 2aflatoxin B1 aldehyde reductase 2aflatoxin aldehyde reductaseepididymis secretory sperm binding proteinF-actin-capping protein subunit betacapZ betacapping actin protein of muscle Z-line beta subunitcapping protein (actin filament) muscle Z-line, betaepididymis secretory sperm binding protein
Modification date2020031320200320
UniProtAcc.

P47756

Ensembl transtripts involved in fusion geneENST00000361640, ENST00000361640, 
Fusion gene scores* DoF score1 X 1 X 1=123 X 15 X 8=2760
# samples 127
** MAII scorelog2(1/1*10)=3.32192809488736log2(27/2760*10)=-3.3536369546147
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: AKR7A3 [Title/Abstract] AND CAPZB [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointAKR7A3(19610489)-CAPZB(19746244), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across AKR7A3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across CAPZB (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-D8-A1JMAKR7A3chr1

19610489

-CAPZBchr1

19746244

-


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Fusion Gene ORF analysis for AKR7A3-CAPZB

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000361640ENST00000375144AKR7A3chr1

19610489

-CAPZBchr1

19746244

-
5CDS-5UTRENST00000361640ENST00000482808AKR7A3chr1

19610489

-CAPZBchr1

19746244

-
In-frameENST00000361640ENST00000264202AKR7A3chr1

19610489

-CAPZBchr1

19746244

-
In-frameENST00000361640ENST00000264203AKR7A3chr1

19610489

-CAPZBchr1

19746244

-
In-frameENST00000361640ENST00000375142AKR7A3chr1

19610489

-CAPZBchr1

19746244

-
In-frameENST00000361640ENST00000401084AKR7A3chr1

19610489

-CAPZBchr1

19746244

-
In-frameENST00000361640ENST00000433834AKR7A3chr1

19610489

-CAPZBchr1

19746244

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000361640AKR7A3chr119610489-ENST00000401084CAPZBchr119746244-294813752562190644
ENST00000361640AKR7A3chr119610489-ENST00000264203CAPZBchr119746244-286813752562076606
ENST00000361640AKR7A3chr119610489-ENST00000375142CAPZBchr119746244-301113752562205649
ENST00000361640AKR7A3chr119610489-ENST00000433834CAPZBchr119746244-236213752562190644
ENST00000361640AKR7A3chr119610489-ENST00000264202CAPZBchr119746244-220613752562205650

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000361640ENST00000401084AKR7A3chr119610489-CAPZBchr119746244-0.0026973650.99730265
ENST00000361640ENST00000264203AKR7A3chr119610489-CAPZBchr119746244-0.0030885290.99691147
ENST00000361640ENST00000375142AKR7A3chr119610489-CAPZBchr119746244-0.0031844010.9968156
ENST00000361640ENST00000433834AKR7A3chr119610489-CAPZBchr119746244-0.0081902180.9918098
ENST00000361640ENST00000264202AKR7A3chr119610489-CAPZBchr119746244-0.0073125260.99268746

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Fusion Genomic Features for AKR7A3-CAPZB


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for AKR7A3-CAPZB


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:19610489/chr1:19746244)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.CAPZB

P47756

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. Plays a role in the regulation of cell morphology and cytoskeletal organization. {ECO:0000269|PubMed:21834987}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneAKR7A3chr1:19610489chr1:19746244ENST00000361640-67143_144278332.0Nucleotide bindingNADP
HgeneAKR7A3chr1:19610489chr1:19746244ENST00000361640-67198_208278332.0Nucleotide bindingNADP

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneAKR7A3chr1:19610489chr1:19746244ENST00000361640-67290_298278332.0Nucleotide bindingNADP


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Fusion Gene Sequence for AKR7A3-CAPZB


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>3458_3458_1_AKR7A3-CAPZB_AKR7A3_chr1_19610489_ENST00000361640_CAPZB_chr1_19746244_ENST00000264202_length(transcript)=2206nt_BP=1375nt
TTCTTTTCTTTCAACACTTTAACCATGTCACTCCATGGGGACGCTGTCTTGAGCCTTTGGTAAGCCTCATTCTCCAGGACCACACGGCAG
GCGCGACAGCCCTAGGTCCACCCCACCCCGTAAGCGCTCCCTCCGGGAGGAGACAGAAACCCAGGACAGCTCCGGGGCAAGGCCGAGGAA
GGAGGGACGACGGGGCAGGGAGGCCCGAAGAGTCCCCGCCTTTTGGGATAGTCGCCACCCTTGGACCCCCTCACCCTTGGGGACGTTGAG
GAGTGTTAAAATCTCCAAGACGCGAGTCACCGGTACGAAGCCACAGCCATTTCGCTGCTTGCTCGGTGCAAGTGCAGAAGGTCCTAGTAG
CCGAGCGTGGAGTCGAGCTCGTGGGCGGCGTCGGGCACCTTCGGCCGCGCCCTCAGCTGCACCCGCCGGTGGGCGGGGCCCGAGCCCGTC
TCTAAAGCCACGAGGCCGCCCGCTCCGAGCCTGGTGCTTCCGACCGCTGCGCGCGGCTCCTGGGCTGTCACAGTCTCCCGTTGCCGCCGT
CATGTCCCGGCAGCTGTCGCGGGCCCGGCCAGCCACGGTGCTGGGCGCCATGGAGATGGGGCGCCGCATGGACGCGCCCACCAGCGCCGC
AGTCACGCGCGCCTTCCTGGAGCGCGGCCACACCGAGATAGACACGGCCTTCGTGTACAGCGAGGGCCAGTCCGAGACCATCCTTGGCGG
CCTGGGGCTCCGGCTGGGCGGCAGCGACTGCAGAGTGAAAATTGATACCAAGGCCATTCCACTGTTTGGGAACTCCCTGAAGCCTGACAG
TCTCCGGTTCCAGCTGGAGACGTCACTGAAGCGGCTGCAGTGTCCCCGAGTGGACCTCTTCTACCTGCATATGCCAGACCACAGCACCCC
GGTGGAAGAGACACTGCGTGCCTGCCACCAGCTGCACCAGGAGGGCAAGTTCGTGGAGCTTGGCCTCTCCAACTATGCAGCCTGGGAAGT
GGCCGAGATCTGTACCCTCTGCAAGAGCAACGGCTGGATCCTGCCCACTGTGTACCAGGGCATGTACAATGCCATCACCCGGCAGGTGGA
AACGGAGCTCTTCCCCTGCCTCAGGCACTTTGGACTGAGGTTCTATGCCTTCAACCCTCTGGCTGGGGGCCTGCTGACCGGCAAGTACAA
GTATGAGGACAAGAATGGGAAACAGCCCGTGGGCCGCTTCTTTGGGAATACCTGGGCAGAGATGTACAGGAATCGCTACTGGAAGGAGCA
CCACTTTGAGGGCATTGCCCTGGTGGAGAAGGCCCTGCAGGCCGCGTATGGCGCCAGCGCCCCCAGCATGACCTCGGCCACCCTCCGGTG
GATGTACCACCACTCACAGCTGCAGAGTGATCAGCAGCTGGACTGTGCCTTGGACCTAATGAGGCGCCTGCCTCCCCAGCAAATCGAGAA
AAACCTCAGCGACCTGATCGACCTGGTCCCCAGTCTATGTGAGGATCTCCTGTCTTCTGTTGACCAGCCACTGAAAATTGCCAGAGACAA
GGTGGTGGGAAAGGATTACCTTTTGTGTGACTACAACAGAGATGGGGACTCCTATAGGTCACCATGGAGTAACAAGTATGACCCTCCCTT
GGAGGATGGGGCCATGCCGTCAGCTCGGCTGAGAAAGCTGGAGGTGGAAGCCAACAATGCCTTTGACCAGTATCGAGACCTGTATTTTGA
AGGTGGCGTCTCATCTGTCTACCTCTGGGATCTGGATCATGGCTTTGCTGGAGTGATCCTCATAAAGAAGGCTGGAGATGGATCAAAGAA
GATCAAAGGCTGCTGGGATTCCATCCACGTGGTAGAAGTGCAGGAGAAATCCAGCGGTCGCACCGCCCATTACAAGTTGACCTCCACGGT
GATGCTGTGGCTGCAGACCAACAAATCTGGCTCTGGCACCATGAACCTCGGAGGCAGCCTTACCAGACAGATGGAGAAGGATGAAACTGT
GAGTGACTGCTCCCCACACATAGCCAACATCGGGCGCCTGGTAGAGGACATGGAAAATAAAATCAGAAGTACGCTGAACGAGATCTACTT
TGGAAAAACAAAGGATATCGTCAATGGGCTGAGATCTATTGATGCTATCCCTGACAACCAAAAGTTTAAGCAGTTGCAGAGGGAGCTCTC

>3458_3458_1_AKR7A3-CAPZB_AKR7A3_chr1_19610489_ENST00000361640_CAPZB_chr1_19746244_ENST00000264202_length(amino acids)=650AA_BP=372
MGTLRSVKISKTRVTGTKPQPFRCLLGASAEGPSSRAWSRARGRRRAPSAAPSAAPAGGRGPSPSLKPRGRPLRAWCFRPLRAAPGLSQS
PVAAVMSRQLSRARPATVLGAMEMGRRMDAPTSAAVTRAFLERGHTEIDTAFVYSEGQSETILGGLGLRLGGSDCRVKIDTKAIPLFGNS
LKPDSLRFQLETSLKRLQCPRVDLFYLHMPDHSTPVEETLRACHQLHQEGKFVELGLSNYAAWEVAEICTLCKSNGWILPTVYQGMYNAI
TRQVETELFPCLRHFGLRFYAFNPLAGGLLTGKYKYEDKNGKQPVGRFFGNTWAEMYRNRYWKEHHFEGIALVEKALQAAYGASAPSMTS
ATLRWMYHHSQLQSDQQLDCALDLMRRLPPQQIEKNLSDLIDLVPSLCEDLLSSVDQPLKIARDKVVGKDYLLCDYNRDGDSYRSPWSNK
YDPPLEDGAMPSARLRKLEVEANNAFDQYRDLYFEGGVSSVYLWDLDHGFAGVILIKKAGDGSKKIKGCWDSIHVVEVQEKSSGRTAHYK
LTSTVMLWLQTNKSGSGTMNLGGSLTRQMEKDETVSDCSPHIANIGRLVEDMENKIRSTLNEIYFGKTKDIVNGLRSIDAIPDNQKFKQL

--------------------------------------------------------------
>3458_3458_2_AKR7A3-CAPZB_AKR7A3_chr1_19610489_ENST00000361640_CAPZB_chr1_19746244_ENST00000264203_length(transcript)=2868nt_BP=1375nt
TTCTTTTCTTTCAACACTTTAACCATGTCACTCCATGGGGACGCTGTCTTGAGCCTTTGGTAAGCCTCATTCTCCAGGACCACACGGCAG
GCGCGACAGCCCTAGGTCCACCCCACCCCGTAAGCGCTCCCTCCGGGAGGAGACAGAAACCCAGGACAGCTCCGGGGCAAGGCCGAGGAA
GGAGGGACGACGGGGCAGGGAGGCCCGAAGAGTCCCCGCCTTTTGGGATAGTCGCCACCCTTGGACCCCCTCACCCTTGGGGACGTTGAG
GAGTGTTAAAATCTCCAAGACGCGAGTCACCGGTACGAAGCCACAGCCATTTCGCTGCTTGCTCGGTGCAAGTGCAGAAGGTCCTAGTAG
CCGAGCGTGGAGTCGAGCTCGTGGGCGGCGTCGGGCACCTTCGGCCGCGCCCTCAGCTGCACCCGCCGGTGGGCGGGGCCCGAGCCCGTC
TCTAAAGCCACGAGGCCGCCCGCTCCGAGCCTGGTGCTTCCGACCGCTGCGCGCGGCTCCTGGGCTGTCACAGTCTCCCGTTGCCGCCGT
CATGTCCCGGCAGCTGTCGCGGGCCCGGCCAGCCACGGTGCTGGGCGCCATGGAGATGGGGCGCCGCATGGACGCGCCCACCAGCGCCGC
AGTCACGCGCGCCTTCCTGGAGCGCGGCCACACCGAGATAGACACGGCCTTCGTGTACAGCGAGGGCCAGTCCGAGACCATCCTTGGCGG
CCTGGGGCTCCGGCTGGGCGGCAGCGACTGCAGAGTGAAAATTGATACCAAGGCCATTCCACTGTTTGGGAACTCCCTGAAGCCTGACAG
TCTCCGGTTCCAGCTGGAGACGTCACTGAAGCGGCTGCAGTGTCCCCGAGTGGACCTCTTCTACCTGCATATGCCAGACCACAGCACCCC
GGTGGAAGAGACACTGCGTGCCTGCCACCAGCTGCACCAGGAGGGCAAGTTCGTGGAGCTTGGCCTCTCCAACTATGCAGCCTGGGAAGT
GGCCGAGATCTGTACCCTCTGCAAGAGCAACGGCTGGATCCTGCCCACTGTGTACCAGGGCATGTACAATGCCATCACCCGGCAGGTGGA
AACGGAGCTCTTCCCCTGCCTCAGGCACTTTGGACTGAGGTTCTATGCCTTCAACCCTCTGGCTGGGGGCCTGCTGACCGGCAAGTACAA
GTATGAGGACAAGAATGGGAAACAGCCCGTGGGCCGCTTCTTTGGGAATACCTGGGCAGAGATGTACAGGAATCGCTACTGGAAGGAGCA
CCACTTTGAGGGCATTGCCCTGGTGGAGAAGGCCCTGCAGGCCGCGTATGGCGCCAGCGCCCCCAGCATGACCTCGGCCACCCTCCGGTG
GATGTACCACCACTCACAGCTGCAGAGTGATCAGCAGCTGGACTGTGCCTTGGACCTAATGAGGCGCCTGCCTCCCCAGCAAATCGAGAA
AAACCTCAGCGACCTGATCGACCTGGTCCCCAGTCTATGTGAGGATCTCCTGTCTTCTGTTGACCAGCCACTGAAAATTGCCAGAGACAA
GGTGGTGGGAAAGGATTACCTTTTGTGTGACTACAACAGAGATGGGGACTCCTATAGGTCACCATGGAGTAACAAGTATGACCCTCCCTT
GGAGGATGGGGCCATGCCGTCAGCTCGGCTGAGAAAGCTGGAGGTGGAAGCCAACAATGCCTTTGACCAGTATCGAGACCTGTATTTTGA
AGGTGGCGTCTCATCTGTCTACCTCTGGGATCTGGATCATGGCTTTGCTGGAGTGATCCTCATAAAGAAGGCTGGAGATGGATCAAAGAA
GATCAAAGGCTGCTGGGATTCCATCCACGTGGTAGAAGTGCAGGAGAAATCCAGCGGTCGCACCGCCCATTACAAGTTGACCTCCACGGT
GATGCTGTGGCTGCAGACCAACAAATCTGGCTCTGGCACCATGAACCTCGGAGGCAGCCTTACCAGACAGATGGAGAAGGATGAAACTGT
GAGTGACTGCTCCCCACACATAGCCAACATCGGGCGCCTGGTAGAGGTCTGTGCAGACTTTTGCAGACAAATCAAAACAAGAAGCTCTGA
AGAATGACCTGGTGGAGGCTTTGAAGAGAAAGCAGCAATGCTAAACCTCTGTTTCATGCTAACCAGACACGCCGTGCACTCGTTAGATTC
CTTTCTTAGAAAACTCGTTTTCTGCTCCCTTCCCTCGTCCCTTCCCTCCCCGACAGGTCACATAACAGCTGCATCATTGACCGCACAGCG
CCATCTCTCCCTGAGAATAAAGCCGATAGCCACCCTCCTCCGGCTCCGAGCCTGCTTCTGCCACACCTCGCTCTCAGTTCTCTCCACATT
TCCATAGAGACCGTGTGGTTTTTGTTCACCCGGGCCCCCCGTCTTCCTCCCTGTCCCCCCATTTATAGGCATAAAATCCACTGTCTGCCA
GCCTCCCTTCCCTCCCACCTTTTTGGTACATTGGTGTAAAAAATGTAAAACAAAAAAATTTTATGAACTAACTGTGGTGTGTGAAAGAGA
GAAGAAAAACTGGAAATCTTATTCCGTGTGTGTTTGGGAGTTGCTTGGGGTTGGGGGTCGTGGGGACAGGGGACAGCTCTGGGAGCAGAG
GTGGCCCTCGGTGCCGTCCTGCGCAGACTCTCCCGTCCCACGGAGGCCGCGGGGTGGGGGCTGGGGGGGGTGCCGCCGACCGTTCCGCTC
TTCCGGCCAGGTGCTTTTCTGTCAATTTCTATGGAATGCAAAAGGAGGTTTTTGTTTTATTTTGTTTTTTTGTAAAGCTTAAGAAAAAAA

>3458_3458_2_AKR7A3-CAPZB_AKR7A3_chr1_19610489_ENST00000361640_CAPZB_chr1_19746244_ENST00000264203_length(amino acids)=606AA_BP=372
MGTLRSVKISKTRVTGTKPQPFRCLLGASAEGPSSRAWSRARGRRRAPSAAPSAAPAGGRGPSPSLKPRGRPLRAWCFRPLRAAPGLSQS
PVAAVMSRQLSRARPATVLGAMEMGRRMDAPTSAAVTRAFLERGHTEIDTAFVYSEGQSETILGGLGLRLGGSDCRVKIDTKAIPLFGNS
LKPDSLRFQLETSLKRLQCPRVDLFYLHMPDHSTPVEETLRACHQLHQEGKFVELGLSNYAAWEVAEICTLCKSNGWILPTVYQGMYNAI
TRQVETELFPCLRHFGLRFYAFNPLAGGLLTGKYKYEDKNGKQPVGRFFGNTWAEMYRNRYWKEHHFEGIALVEKALQAAYGASAPSMTS
ATLRWMYHHSQLQSDQQLDCALDLMRRLPPQQIEKNLSDLIDLVPSLCEDLLSSVDQPLKIARDKVVGKDYLLCDYNRDGDSYRSPWSNK
YDPPLEDGAMPSARLRKLEVEANNAFDQYRDLYFEGGVSSVYLWDLDHGFAGVILIKKAGDGSKKIKGCWDSIHVVEVQEKSSGRTAHYK

--------------------------------------------------------------
>3458_3458_3_AKR7A3-CAPZB_AKR7A3_chr1_19610489_ENST00000361640_CAPZB_chr1_19746244_ENST00000375142_length(transcript)=3011nt_BP=1375nt
TTCTTTTCTTTCAACACTTTAACCATGTCACTCCATGGGGACGCTGTCTTGAGCCTTTGGTAAGCCTCATTCTCCAGGACCACACGGCAG
GCGCGACAGCCCTAGGTCCACCCCACCCCGTAAGCGCTCCCTCCGGGAGGAGACAGAAACCCAGGACAGCTCCGGGGCAAGGCCGAGGAA
GGAGGGACGACGGGGCAGGGAGGCCCGAAGAGTCCCCGCCTTTTGGGATAGTCGCCACCCTTGGACCCCCTCACCCTTGGGGACGTTGAG
GAGTGTTAAAATCTCCAAGACGCGAGTCACCGGTACGAAGCCACAGCCATTTCGCTGCTTGCTCGGTGCAAGTGCAGAAGGTCCTAGTAG
CCGAGCGTGGAGTCGAGCTCGTGGGCGGCGTCGGGCACCTTCGGCCGCGCCCTCAGCTGCACCCGCCGGTGGGCGGGGCCCGAGCCCGTC
TCTAAAGCCACGAGGCCGCCCGCTCCGAGCCTGGTGCTTCCGACCGCTGCGCGCGGCTCCTGGGCTGTCACAGTCTCCCGTTGCCGCCGT
CATGTCCCGGCAGCTGTCGCGGGCCCGGCCAGCCACGGTGCTGGGCGCCATGGAGATGGGGCGCCGCATGGACGCGCCCACCAGCGCCGC
AGTCACGCGCGCCTTCCTGGAGCGCGGCCACACCGAGATAGACACGGCCTTCGTGTACAGCGAGGGCCAGTCCGAGACCATCCTTGGCGG
CCTGGGGCTCCGGCTGGGCGGCAGCGACTGCAGAGTGAAAATTGATACCAAGGCCATTCCACTGTTTGGGAACTCCCTGAAGCCTGACAG
TCTCCGGTTCCAGCTGGAGACGTCACTGAAGCGGCTGCAGTGTCCCCGAGTGGACCTCTTCTACCTGCATATGCCAGACCACAGCACCCC
GGTGGAAGAGACACTGCGTGCCTGCCACCAGCTGCACCAGGAGGGCAAGTTCGTGGAGCTTGGCCTCTCCAACTATGCAGCCTGGGAAGT
GGCCGAGATCTGTACCCTCTGCAAGAGCAACGGCTGGATCCTGCCCACTGTGTACCAGGGCATGTACAATGCCATCACCCGGCAGGTGGA
AACGGAGCTCTTCCCCTGCCTCAGGCACTTTGGACTGAGGTTCTATGCCTTCAACCCTCTGGCTGGGGGCCTGCTGACCGGCAAGTACAA
GTATGAGGACAAGAATGGGAAACAGCCCGTGGGCCGCTTCTTTGGGAATACCTGGGCAGAGATGTACAGGAATCGCTACTGGAAGGAGCA
CCACTTTGAGGGCATTGCCCTGGTGGAGAAGGCCCTGCAGGCCGCGTATGGCGCCAGCGCCCCCAGCATGACCTCGGCCACCCTCCGGTG
GATGTACCACCACTCACAGCTGCAGAGTGATCAGCAGCTGGACTGTGCCTTGGACCTAATGAGGCGCCTGCCTCCCCAGCAAATCGAGAA
AAACCTCAGCGACCTGATCGACCTGGTCCCCAGTCTATGTGAGGATCTCCTGTCTTCTGTTGACCAGCCACTGAAAATTGCCAGAGACAA
GGTGGTGGGAAAGGATTACCTTTTGTGTGACTACAACAGAGATGGGGACTCCTATAGGTCACCATGGAGTAACAAGTATGACCCTCCCTT
GGAGGATGGGGCCATGCCGTCAGCTCGGCTGAGAAAGCTGGAGGTGGAAGCCAACAATGCCTTTGACCAGTATCGAGACCTGTATTTTGA
AGGTGGCGTCTCATCTGTCTACCTCTGGGATCTGGATCATGGCTTTGCTGGAGTGATCCTCATAAAGAAGGCTGGAGATGGATCAAAGAA
GATCAAAGGCTGCTGGGATTCCATCCACGTGGTAGAAGTGCAGGAGAAATCCAGCGGTCGCACCGCCCATTACAAGTTGACCTCCACGGT
GATGCTGTGGCTGCAGACCAACAAATCTGGCTCTGGCACCATGAACCTCGGAGGCAGCCTTACCAGACAGATGGAGAAGGATGAAACTGT
GAGTGACTGCTCCCCACACATAGCCAACATCGGGCGCCTGGTAGAGGACATGGAAAATAAAATCAGAAGTACGCTGAACGAGATCTACTT
TGGAAAAACAAAGGATATCGTCAATGGGCTGAGATCTATTGATGCTATCCCTGACAACCAAAAGTTTAAGCAGTTGCAGAGGGAGCTCTC
TCAAGTGCTGACCCAGCGCCAGATCTACATCCAGCCTGATAATTAAGCCGATCCAGGTCTGTGCAGACTTTTGCAGACAAATCAAAACAA
GAAGCTCTGAAGAATGACCTGGTGGAGGCTTTGAAGAGAAAGCAGCAATGCTAAACCTCTGTTTCATGCTAACCAGACACGCCGTGCACT
CGTTAGATTCCTTTCTTAGAAAACTCGTTTTCTGCTCCCTTCCCTCGTCCCTTCCCTCCCCGACAGGTCACATAACAGCTGCATCATTGA
CCGCACAGCGCCATCTCTCCCTGAGAATAAAGCCGATAGCCACCCTCCTCCGGCTCCGAGCCTGCTTCTGCCACACCTCGCTCTCAGTTC
TCTCCACATTTCCATAGAGACCGTGTGGTTTTTGTTCACCCGGGCCCCCCGTCTTCCTCCCTGTCCCCCCATTTATAGGCATAAAATCCA
CTGTCTGCCAGCCTCCCTTCCCTCCCACCTTTTTGGTACATTGGTGTAAAAAATGTAAAACAAAAAAATTTTATGAACTAACTGTGGTGT
GTGAAAGAGAGAAGAAAAACTGGAAATCTTATTCCGTGTGTGTTTGGGAGTTGCTTGGGGTTGGGGGTCGTGGGGACAGGGGACAGCTCT
GGGAGCAGAGGTGGCCCTCGGTGCCGTCCTGCGCAGACTCTCCCGTCCCACGGAGGCCGCGGGGTGGGGGCTGGGGGGGGTGCCGCCGAC
CGTTCCGCTCTTCCGGCCAGGTGCTTTTCTGTCAATTTCTATGGAATGCAAAAGGAGGTTTTTGTTTTATTTTGTTTTTTTGTAAAGCTT

>3458_3458_3_AKR7A3-CAPZB_AKR7A3_chr1_19610489_ENST00000361640_CAPZB_chr1_19746244_ENST00000375142_length(amino acids)=649AA_BP=372
MGTLRSVKISKTRVTGTKPQPFRCLLGASAEGPSSRAWSRARGRRRAPSAAPSAAPAGGRGPSPSLKPRGRPLRAWCFRPLRAAPGLSQS
PVAAVMSRQLSRARPATVLGAMEMGRRMDAPTSAAVTRAFLERGHTEIDTAFVYSEGQSETILGGLGLRLGGSDCRVKIDTKAIPLFGNS
LKPDSLRFQLETSLKRLQCPRVDLFYLHMPDHSTPVEETLRACHQLHQEGKFVELGLSNYAAWEVAEICTLCKSNGWILPTVYQGMYNAI
TRQVETELFPCLRHFGLRFYAFNPLAGGLLTGKYKYEDKNGKQPVGRFFGNTWAEMYRNRYWKEHHFEGIALVEKALQAAYGASAPSMTS
ATLRWMYHHSQLQSDQQLDCALDLMRRLPPQQIEKNLSDLIDLVPSLCEDLLSSVDQPLKIARDKVVGKDYLLCDYNRDGDSYRSPWSNK
YDPPLEDGAMPSARLRKLEVEANNAFDQYRDLYFEGGVSSVYLWDLDHGFAGVILIKKAGDGSKKIKGCWDSIHVVEVQEKSSGRTAHYK
LTSTVMLWLQTNKSGSGTMNLGGSLTRQMEKDETVSDCSPHIANIGRLVEDMENKIRSTLNEIYFGKTKDIVNGLRSIDAIPDNQKFKQL

--------------------------------------------------------------
>3458_3458_4_AKR7A3-CAPZB_AKR7A3_chr1_19610489_ENST00000361640_CAPZB_chr1_19746244_ENST00000401084_length(transcript)=2948nt_BP=1375nt
TTCTTTTCTTTCAACACTTTAACCATGTCACTCCATGGGGACGCTGTCTTGAGCCTTTGGTAAGCCTCATTCTCCAGGACCACACGGCAG
GCGCGACAGCCCTAGGTCCACCCCACCCCGTAAGCGCTCCCTCCGGGAGGAGACAGAAACCCAGGACAGCTCCGGGGCAAGGCCGAGGAA
GGAGGGACGACGGGGCAGGGAGGCCCGAAGAGTCCCCGCCTTTTGGGATAGTCGCCACCCTTGGACCCCCTCACCCTTGGGGACGTTGAG
GAGTGTTAAAATCTCCAAGACGCGAGTCACCGGTACGAAGCCACAGCCATTTCGCTGCTTGCTCGGTGCAAGTGCAGAAGGTCCTAGTAG
CCGAGCGTGGAGTCGAGCTCGTGGGCGGCGTCGGGCACCTTCGGCCGCGCCCTCAGCTGCACCCGCCGGTGGGCGGGGCCCGAGCCCGTC
TCTAAAGCCACGAGGCCGCCCGCTCCGAGCCTGGTGCTTCCGACCGCTGCGCGCGGCTCCTGGGCTGTCACAGTCTCCCGTTGCCGCCGT
CATGTCCCGGCAGCTGTCGCGGGCCCGGCCAGCCACGGTGCTGGGCGCCATGGAGATGGGGCGCCGCATGGACGCGCCCACCAGCGCCGC
AGTCACGCGCGCCTTCCTGGAGCGCGGCCACACCGAGATAGACACGGCCTTCGTGTACAGCGAGGGCCAGTCCGAGACCATCCTTGGCGG
CCTGGGGCTCCGGCTGGGCGGCAGCGACTGCAGAGTGAAAATTGATACCAAGGCCATTCCACTGTTTGGGAACTCCCTGAAGCCTGACAG
TCTCCGGTTCCAGCTGGAGACGTCACTGAAGCGGCTGCAGTGTCCCCGAGTGGACCTCTTCTACCTGCATATGCCAGACCACAGCACCCC
GGTGGAAGAGACACTGCGTGCCTGCCACCAGCTGCACCAGGAGGGCAAGTTCGTGGAGCTTGGCCTCTCCAACTATGCAGCCTGGGAAGT
GGCCGAGATCTGTACCCTCTGCAAGAGCAACGGCTGGATCCTGCCCACTGTGTACCAGGGCATGTACAATGCCATCACCCGGCAGGTGGA
AACGGAGCTCTTCCCCTGCCTCAGGCACTTTGGACTGAGGTTCTATGCCTTCAACCCTCTGGCTGGGGGCCTGCTGACCGGCAAGTACAA
GTATGAGGACAAGAATGGGAAACAGCCCGTGGGCCGCTTCTTTGGGAATACCTGGGCAGAGATGTACAGGAATCGCTACTGGAAGGAGCA
CCACTTTGAGGGCATTGCCCTGGTGGAGAAGGCCCTGCAGGCCGCGTATGGCGCCAGCGCCCCCAGCATGACCTCGGCCACCCTCCGGTG
GATGTACCACCACTCACAGCTGCAGAGTGATCAGCAGCTGGACTGTGCCTTGGACCTAATGAGGCGCCTGCCTCCCCAGCAAATCGAGAA
AAACCTCAGCGACCTGATCGACCTGGTCCCCAGTCTATGTGAGGATCTCCTGTCTTCTGTTGACCAGCCACTGAAAATTGCCAGAGACAA
GGTGGTGGGAAAGGATTACCTTTTGTGTGACTACAACAGAGATGGGGACTCCTATAGGTCACCATGGAGTAACAAGTATGACCCTCCCTT
GGAGGATGGGGCCATGCCGTCAGCTCGGCTGAGAAAGCTGGAGGTGGAAGCCAACAATGCCTTTGACCAGTATCGAGACCTGTATTTTGA
AGGTGGCGTCTCATCTGTCTACCTCTGGGATCTGGATCATGGCTTTGCTGGAGTGATCCTCATAAAGAAGGCTGGAGATGGATCAAAGAA
GATCAAAGGCTGCTGGGATTCCATCCACGTGGTAGAAGTGCAGGAGAAATCCAGCGGTCGCACCGCCCATTACAAGTTGACCTCCACGGT
GATGCTGTGGCTGCAGACCAACAAATCTGGCTCTGGCACCATGAACCTCGGAGGCAGCCTTACCAGACAGATGGAGAAGGATGAAACTGT
GAGTGACTGCTCCCCACACATAGCCAACATCGGGCGCCTGGTAGAGGACATGGAAAATAAAATCAGAAGTACGCTGAACGAGATCTACTT
TGGAAAAACAAAGGATATCGTCAATGGGCTGAGGTCTGTGCAGACTTTTGCAGACAAATCAAAACAAGAAGCTCTGAAGAATGACCTGGT
GGAGGCTTTGAAGAGAAAGCAGCAATGCTAAACCTCTGTTTCATGCTAACCAGACACGCCGTGCACTCGTTAGATTCCTTTCTTAGAAAA
CTCGTTTTCTGCTCCCTTCCCTCGTCCCTTCCCTCCCCGACAGGTCACATAACAGCTGCATCATTGACCGCACAGCGCCATCTCTCCCTG
AGAATAAAGCCGATAGCCACCCTCCTCCGGCTCCGAGCCTGCTTCTGCCACACCTCGCTCTCAGTTCTCTCCACATTTCCATAGAGACCG
TGTGGTTTTTGTTCACCCGGGCCCCCCGTCTTCCTCCCTGTCCCCCCATTTATAGGCATAAAATCCACTGTCTGCCAGCCTCCCTTCCCT
CCCACCTTTTTGGTACATTGGTGTAAAAAATGTAAAACAAAAAAATTTTATGAACTAACTGTGGTGTGTGAAAGAGAGAAGAAAAACTGG
AAATCTTATTCCGTGTGTGTTTGGGAGTTGCTTGGGGTTGGGGGTCGTGGGGACAGGGGACAGCTCTGGGAGCAGAGGTGGCCCTCGGTG
CCGTCCTGCGCAGACTCTCCCGTCCCACGGAGGCCGCGGGGTGGGGGCTGGGGGGGGTGCCGCCGACCGTTCCGCTCTTCCGGCCAGGTG
CTTTTCTGTCAATTTCTATGGAATGCAAAAGGAGGTTTTTGTTTTATTTTGTTTTTTTGTAAAGCTTAAGAAAAAAATCTACATCTTATA

>3458_3458_4_AKR7A3-CAPZB_AKR7A3_chr1_19610489_ENST00000361640_CAPZB_chr1_19746244_ENST00000401084_length(amino acids)=644AA_BP=372
MGTLRSVKISKTRVTGTKPQPFRCLLGASAEGPSSRAWSRARGRRRAPSAAPSAAPAGGRGPSPSLKPRGRPLRAWCFRPLRAAPGLSQS
PVAAVMSRQLSRARPATVLGAMEMGRRMDAPTSAAVTRAFLERGHTEIDTAFVYSEGQSETILGGLGLRLGGSDCRVKIDTKAIPLFGNS
LKPDSLRFQLETSLKRLQCPRVDLFYLHMPDHSTPVEETLRACHQLHQEGKFVELGLSNYAAWEVAEICTLCKSNGWILPTVYQGMYNAI
TRQVETELFPCLRHFGLRFYAFNPLAGGLLTGKYKYEDKNGKQPVGRFFGNTWAEMYRNRYWKEHHFEGIALVEKALQAAYGASAPSMTS
ATLRWMYHHSQLQSDQQLDCALDLMRRLPPQQIEKNLSDLIDLVPSLCEDLLSSVDQPLKIARDKVVGKDYLLCDYNRDGDSYRSPWSNK
YDPPLEDGAMPSARLRKLEVEANNAFDQYRDLYFEGGVSSVYLWDLDHGFAGVILIKKAGDGSKKIKGCWDSIHVVEVQEKSSGRTAHYK
LTSTVMLWLQTNKSGSGTMNLGGSLTRQMEKDETVSDCSPHIANIGRLVEDMENKIRSTLNEIYFGKTKDIVNGLRSVQTFADKSKQEAL

--------------------------------------------------------------
>3458_3458_5_AKR7A3-CAPZB_AKR7A3_chr1_19610489_ENST00000361640_CAPZB_chr1_19746244_ENST00000433834_length(transcript)=2362nt_BP=1375nt
TTCTTTTCTTTCAACACTTTAACCATGTCACTCCATGGGGACGCTGTCTTGAGCCTTTGGTAAGCCTCATTCTCCAGGACCACACGGCAG
GCGCGACAGCCCTAGGTCCACCCCACCCCGTAAGCGCTCCCTCCGGGAGGAGACAGAAACCCAGGACAGCTCCGGGGCAAGGCCGAGGAA
GGAGGGACGACGGGGCAGGGAGGCCCGAAGAGTCCCCGCCTTTTGGGATAGTCGCCACCCTTGGACCCCCTCACCCTTGGGGACGTTGAG
GAGTGTTAAAATCTCCAAGACGCGAGTCACCGGTACGAAGCCACAGCCATTTCGCTGCTTGCTCGGTGCAAGTGCAGAAGGTCCTAGTAG
CCGAGCGTGGAGTCGAGCTCGTGGGCGGCGTCGGGCACCTTCGGCCGCGCCCTCAGCTGCACCCGCCGGTGGGCGGGGCCCGAGCCCGTC
TCTAAAGCCACGAGGCCGCCCGCTCCGAGCCTGGTGCTTCCGACCGCTGCGCGCGGCTCCTGGGCTGTCACAGTCTCCCGTTGCCGCCGT
CATGTCCCGGCAGCTGTCGCGGGCCCGGCCAGCCACGGTGCTGGGCGCCATGGAGATGGGGCGCCGCATGGACGCGCCCACCAGCGCCGC
AGTCACGCGCGCCTTCCTGGAGCGCGGCCACACCGAGATAGACACGGCCTTCGTGTACAGCGAGGGCCAGTCCGAGACCATCCTTGGCGG
CCTGGGGCTCCGGCTGGGCGGCAGCGACTGCAGAGTGAAAATTGATACCAAGGCCATTCCACTGTTTGGGAACTCCCTGAAGCCTGACAG
TCTCCGGTTCCAGCTGGAGACGTCACTGAAGCGGCTGCAGTGTCCCCGAGTGGACCTCTTCTACCTGCATATGCCAGACCACAGCACCCC
GGTGGAAGAGACACTGCGTGCCTGCCACCAGCTGCACCAGGAGGGCAAGTTCGTGGAGCTTGGCCTCTCCAACTATGCAGCCTGGGAAGT
GGCCGAGATCTGTACCCTCTGCAAGAGCAACGGCTGGATCCTGCCCACTGTGTACCAGGGCATGTACAATGCCATCACCCGGCAGGTGGA
AACGGAGCTCTTCCCCTGCCTCAGGCACTTTGGACTGAGGTTCTATGCCTTCAACCCTCTGGCTGGGGGCCTGCTGACCGGCAAGTACAA
GTATGAGGACAAGAATGGGAAACAGCCCGTGGGCCGCTTCTTTGGGAATACCTGGGCAGAGATGTACAGGAATCGCTACTGGAAGGAGCA
CCACTTTGAGGGCATTGCCCTGGTGGAGAAGGCCCTGCAGGCCGCGTATGGCGCCAGCGCCCCCAGCATGACCTCGGCCACCCTCCGGTG
GATGTACCACCACTCACAGCTGCAGAGTGATCAGCAGCTGGACTGTGCCTTGGACCTAATGAGGCGCCTGCCTCCCCAGCAAATCGAGAA
AAACCTCAGCGACCTGATCGACCTGGTCCCCAGTCTATGTGAGGATCTCCTGTCTTCTGTTGACCAGCCACTGAAAATTGCCAGAGACAA
GGTGGTGGGAAAGGATTACCTTTTGTGTGACTACAACAGAGATGGGGACTCCTATAGGTCACCATGGAGTAACAAGTATGACCCTCCCTT
GGAGGATGGGGCCATGCCGTCAGCTCGGCTGAGAAAGCTGGAGGTGGAAGCCAACAATGCCTTTGACCAGTATCGAGACCTGTATTTTGA
AGGTGGCGTCTCATCTGTCTACCTCTGGGATCTGGATCATGGCTTTGCTGGAGTGATCCTCATAAAGAAGGCTGGAGATGGATCAAAGAA
GATCAAAGGCTGCTGGGATTCCATCCACGTGGTAGAAGTGCAGGAGAAATCCAGCGGTCGCACCGCCCATTACAAGTTGACCTCCACGGT
GATGCTGTGGCTGCAGACCAACAAATCTGGCTCTGGCACCATGAACCTCGGAGGCAGCCTTACCAGACAGATGGAGAAGGATGAAACTGT
GAGTGACTGCTCCCCACACATAGCCAACATCGGGCGCCTGGTAGAGGACATGGAAAATAAAATCAGAAGTACGCTGAACGAGATCTACTT
TGGAAAAACAAAGGATATCGTCAATGGGCTGAGGTCTGTGCAGACTTTTGCAGACAAATCAAAACAAGAAGCTCTGAAGAATGACCTGGT
GGAGGCTTTGAAGAGAAAGCAGCAATGCTAAACCTCTGTTTCATGCTAACCAGACACGCCGTGCACTCGTTAGATTCCTTTCTTAGAAAA
CTCGTTTTCTGCTCCCTTCCCTCGTCCCTTCCCTCCCCGACAGGTCACATAACAGCTGCATCATTGACCGCACAGCGCCATCTCTCCCTG

>3458_3458_5_AKR7A3-CAPZB_AKR7A3_chr1_19610489_ENST00000361640_CAPZB_chr1_19746244_ENST00000433834_length(amino acids)=644AA_BP=372
MGTLRSVKISKTRVTGTKPQPFRCLLGASAEGPSSRAWSRARGRRRAPSAAPSAAPAGGRGPSPSLKPRGRPLRAWCFRPLRAAPGLSQS
PVAAVMSRQLSRARPATVLGAMEMGRRMDAPTSAAVTRAFLERGHTEIDTAFVYSEGQSETILGGLGLRLGGSDCRVKIDTKAIPLFGNS
LKPDSLRFQLETSLKRLQCPRVDLFYLHMPDHSTPVEETLRACHQLHQEGKFVELGLSNYAAWEVAEICTLCKSNGWILPTVYQGMYNAI
TRQVETELFPCLRHFGLRFYAFNPLAGGLLTGKYKYEDKNGKQPVGRFFGNTWAEMYRNRYWKEHHFEGIALVEKALQAAYGASAPSMTS
ATLRWMYHHSQLQSDQQLDCALDLMRRLPPQQIEKNLSDLIDLVPSLCEDLLSSVDQPLKIARDKVVGKDYLLCDYNRDGDSYRSPWSNK
YDPPLEDGAMPSARLRKLEVEANNAFDQYRDLYFEGGVSSVYLWDLDHGFAGVILIKKAGDGSKKIKGCWDSIHVVEVQEKSSGRTAHYK
LTSTVMLWLQTNKSGSGTMNLGGSLTRQMEKDETVSDCSPHIANIGRLVEDMENKIRSTLNEIYFGKTKDIVNGLRSVQTFADKSKQEAL

--------------------------------------------------------------

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Fusion Gene PPI Analysis for AKR7A3-CAPZB


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for AKR7A3-CAPZB


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for AKR7A3-CAPZB


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneAKR7A3C0019209Hepatomegaly1CTD_human
TgeneC0007097Carcinoma1CTD_human
TgeneC0024667Animal Mammary Neoplasms1CTD_human
TgeneC0024668Mammary Neoplasms, Experimental1CTD_human
TgeneC0205696Anaplastic carcinoma1CTD_human
TgeneC0205697Carcinoma, Spindle-Cell1CTD_human
TgeneC0205698Undifferentiated carcinoma1CTD_human
TgeneC0205699Carcinomatosis1CTD_human
TgeneC0948089Acute Coronary Syndrome1CTD_human
TgeneC1257925Mammary Carcinoma, Animal1CTD_human