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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:AVL9-ZNF544 (FusionGDB2 ID:HG23080TG27300)

Fusion Gene Summary for AVL9-ZNF544

check button Fusion gene summary
Fusion gene informationFusion gene name: AVL9-ZNF544
Fusion gene ID: hg23080tg27300
HgeneTgene
Gene symbol

AVL9

ZNF544

Gene ID

23080

27300

Gene nameAVL9 cell migration associatedzinc finger protein 544
SynonymsKIAA0241-
Cytomap('AVL9')('ZNF544')

7p14.3

19q13.43

Type of geneprotein-codingprotein-coding
Descriptionlate secretory pathway protein AVL9 homologAVL9 homolog (S. cerevisiase)zinc finger protein 544
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000459629, ENST00000318709, 
ENST00000404479, ENST00000409301, 
Fusion gene scores* DoF score10 X 3 X 7=2105 X 5 X 4=100
# samples 125
** MAII scorelog2(12/210*10)=-0.807354922057604
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(5/100*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: AVL9 [Title/Abstract] AND ZNF544 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointAVL9(32535414)-ZNF544(58772217), # samples:2
Anticipated loss of major functional domain due to fusion event.AVL9-ZNF544 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
AVL9-ZNF544 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
AVL9-ZNF544 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
AVL9-ZNF544 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
AVL9-ZNF544 seems lost the major protein functional domain in Tgene partner, which is a transcription factor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneAVL9

GO:0016477

cell migration

22595670


check buttonFusion gene breakpoints across AVL9 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across ZNF544 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4GBMTCGA-32-1970-01AAVL9chr7

32535414

+ZNF544chr19

58772217

+


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Fusion Gene ORF analysis for AVL9-ZNF544

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000459629ENST00000269829AVL9chr7

32535414

+ZNF544chr19

58772217

+
3UTR-3CDSENST00000459629ENST00000594384AVL9chr7

32535414

+ZNF544chr19

58772217

+
3UTR-3CDSENST00000459629ENST00000599227AVL9chr7

32535414

+ZNF544chr19

58772217

+
3UTR-5UTRENST00000459629ENST00000596652AVL9chr7

32535414

+ZNF544chr19

58772217

+
3UTR-5UTRENST00000459629ENST00000599953AVL9chr7

32535414

+ZNF544chr19

58772217

+
3UTR-5UTRENST00000459629ENST00000600044AVL9chr7

32535414

+ZNF544chr19

58772217

+
3UTR-5UTRENST00000459629ENST00000600220AVL9chr7

32535414

+ZNF544chr19

58772217

+
3UTR-intronENST00000459629ENST00000333581AVL9chr7

32535414

+ZNF544chr19

58772217

+
3UTR-intronENST00000459629ENST00000415203AVL9chr7

32535414

+ZNF544chr19

58772217

+
3UTR-intronENST00000459629ENST00000595981AVL9chr7

32535414

+ZNF544chr19

58772217

+
3UTR-intronENST00000459629ENST00000596597AVL9chr7

32535414

+ZNF544chr19

58772217

+
3UTR-intronENST00000459629ENST00000596825AVL9chr7

32535414

+ZNF544chr19

58772217

+
3UTR-intronENST00000459629ENST00000596929AVL9chr7

32535414

+ZNF544chr19

58772217

+
5CDS-5UTRENST00000318709ENST00000596652AVL9chr7

32535414

+ZNF544chr19

58772217

+
5CDS-5UTRENST00000318709ENST00000599953AVL9chr7

32535414

+ZNF544chr19

58772217

+
5CDS-5UTRENST00000318709ENST00000600044AVL9chr7

32535414

+ZNF544chr19

58772217

+
5CDS-5UTRENST00000318709ENST00000600220AVL9chr7

32535414

+ZNF544chr19

58772217

+
5CDS-5UTRENST00000404479ENST00000596652AVL9chr7

32535414

+ZNF544chr19

58772217

+
5CDS-5UTRENST00000404479ENST00000599953AVL9chr7

32535414

+ZNF544chr19

58772217

+
5CDS-5UTRENST00000404479ENST00000600044AVL9chr7

32535414

+ZNF544chr19

58772217

+
5CDS-5UTRENST00000404479ENST00000600220AVL9chr7

32535414

+ZNF544chr19

58772217

+
5CDS-5UTRENST00000409301ENST00000596652AVL9chr7

32535414

+ZNF544chr19

58772217

+
5CDS-5UTRENST00000409301ENST00000599953AVL9chr7

32535414

+ZNF544chr19

58772217

+
5CDS-5UTRENST00000409301ENST00000600044AVL9chr7

32535414

+ZNF544chr19

58772217

+
5CDS-5UTRENST00000409301ENST00000600220AVL9chr7

32535414

+ZNF544chr19

58772217

+
5CDS-intronENST00000318709ENST00000333581AVL9chr7

32535414

+ZNF544chr19

58772217

+
5CDS-intronENST00000318709ENST00000415203AVL9chr7

32535414

+ZNF544chr19

58772217

+
5CDS-intronENST00000318709ENST00000595981AVL9chr7

32535414

+ZNF544chr19

58772217

+
5CDS-intronENST00000318709ENST00000596597AVL9chr7

32535414

+ZNF544chr19

58772217

+
5CDS-intronENST00000318709ENST00000596825AVL9chr7

32535414

+ZNF544chr19

58772217

+
5CDS-intronENST00000318709ENST00000596929AVL9chr7

32535414

+ZNF544chr19

58772217

+
5CDS-intronENST00000404479ENST00000333581AVL9chr7

32535414

+ZNF544chr19

58772217

+
5CDS-intronENST00000404479ENST00000415203AVL9chr7

32535414

+ZNF544chr19

58772217

+
5CDS-intronENST00000404479ENST00000595981AVL9chr7

32535414

+ZNF544chr19

58772217

+
5CDS-intronENST00000404479ENST00000596597AVL9chr7

32535414

+ZNF544chr19

58772217

+
5CDS-intronENST00000404479ENST00000596825AVL9chr7

32535414

+ZNF544chr19

58772217

+
5CDS-intronENST00000404479ENST00000596929AVL9chr7

32535414

+ZNF544chr19

58772217

+
5CDS-intronENST00000409301ENST00000333581AVL9chr7

32535414

+ZNF544chr19

58772217

+
5CDS-intronENST00000409301ENST00000415203AVL9chr7

32535414

+ZNF544chr19

58772217

+
5CDS-intronENST00000409301ENST00000595981AVL9chr7

32535414

+ZNF544chr19

58772217

+
5CDS-intronENST00000409301ENST00000596597AVL9chr7

32535414

+ZNF544chr19

58772217

+
5CDS-intronENST00000409301ENST00000596825AVL9chr7

32535414

+ZNF544chr19

58772217

+
5CDS-intronENST00000409301ENST00000596929AVL9chr7

32535414

+ZNF544chr19

58772217

+
Frame-shiftENST00000318709ENST00000269829AVL9chr7

32535414

+ZNF544chr19

58772217

+
Frame-shiftENST00000404479ENST00000269829AVL9chr7

32535414

+ZNF544chr19

58772217

+
Frame-shiftENST00000409301ENST00000269829AVL9chr7

32535414

+ZNF544chr19

58772217

+
In-frameENST00000318709ENST00000594384AVL9chr7

32535414

+ZNF544chr19

58772217

+
In-frameENST00000318709ENST00000599227AVL9chr7

32535414

+ZNF544chr19

58772217

+
In-frameENST00000404479ENST00000594384AVL9chr7

32535414

+ZNF544chr19

58772217

+
In-frameENST00000404479ENST00000599227AVL9chr7

32535414

+ZNF544chr19

58772217

+
In-frameENST00000409301ENST00000594384AVL9chr7

32535414

+ZNF544chr19

58772217

+
In-frameENST00000409301ENST00000599227AVL9chr7

32535414

+ZNF544chr19

58772217

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000404479AVL9chr732535414+ENST00000599227ZNF544chr1958772217+288793861996636
ENST00000404479AVL9chr732535414+ENST00000594384ZNF544chr1958772217+20893180160
ENST00000318709AVL9chr732535414+ENST00000599227ZNF544chr1958772217+31083143072217636
ENST00000318709AVL9chr732535414+ENST00000594384ZNF544chr1958772217+4293145733291
ENST00000409301AVL9chr732535414+ENST00000599227ZNF544chr1958772217+30712772702180636
ENST00000409301AVL9chr732535414+ENST00000594384ZNF544chr1958772217+3922772029591

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000404479ENST00000599227AVL9chr732535414+ZNF544chr1958772217+0.0014834770.9985165
ENST00000404479ENST00000594384AVL9chr732535414+ZNF544chr1958772217+0.380427330.6195727
ENST00000318709ENST00000599227AVL9chr732535414+ZNF544chr1958772217+0.0016344860.99836546
ENST00000318709ENST00000594384AVL9chr732535414+ZNF544chr1958772217+0.545158150.45484185
ENST00000409301ENST00000599227AVL9chr732535414+ZNF544chr1958772217+0.0016170610.9983829
ENST00000409301ENST00000594384AVL9chr732535414+ZNF544chr1958772217+0.52702160.47297844

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Fusion Genomic Features for AVL9-ZNF544


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
AVL9chr732535414+ZNF544chr1958772216+1.15E-060.9999988
AVL9chr732535414+ZNF544chr1958772216+1.15E-060.9999988

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for AVL9-ZNF544


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr7:32535414/chr19:58772217)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneZNF544chr7:32535414chr19:58772217ENST0000026982957354_37481716.0Zinc fingerC2H2-type 1%3B atypical
TgeneZNF544chr7:32535414chr19:58772217ENST0000026982957380_40281716.0Zinc fingerC2H2-type 2
TgeneZNF544chr7:32535414chr19:58772217ENST0000026982957408_43081716.0Zinc fingerC2H2-type 3
TgeneZNF544chr7:32535414chr19:58772217ENST0000026982957436_45881716.0Zinc fingerC2H2-type 4
TgeneZNF544chr7:32535414chr19:58772217ENST0000026982957464_48681716.0Zinc fingerC2H2-type 5
TgeneZNF544chr7:32535414chr19:58772217ENST0000026982957492_51481716.0Zinc fingerC2H2-type 6
TgeneZNF544chr7:32535414chr19:58772217ENST0000026982957520_54281716.0Zinc fingerC2H2-type 7
TgeneZNF544chr7:32535414chr19:58772217ENST0000026982957548_57081716.0Zinc fingerC2H2-type 8
TgeneZNF544chr7:32535414chr19:58772217ENST0000026982957576_59881716.0Zinc fingerC2H2-type 9
TgeneZNF544chr7:32535414chr19:58772217ENST0000026982957604_62681716.0Zinc fingerC2H2-type 10
TgeneZNF544chr7:32535414chr19:58772217ENST0000026982957632_65481716.0Zinc fingerC2H2-type 11
TgeneZNF544chr7:32535414chr19:58772217ENST0000026982957660_68281716.0Zinc fingerC2H2-type 12
TgeneZNF544chr7:32535414chr19:58772217ENST0000026982957688_71081716.0Zinc fingerC2H2-type 13
TgeneZNF544chr7:32535414chr19:58772217ENST0000059665246354_37481716.0Zinc fingerC2H2-type 1%3B atypical
TgeneZNF544chr7:32535414chr19:58772217ENST0000059665246380_40281716.0Zinc fingerC2H2-type 2
TgeneZNF544chr7:32535414chr19:58772217ENST0000059665246408_43081716.0Zinc fingerC2H2-type 3
TgeneZNF544chr7:32535414chr19:58772217ENST0000059665246436_45881716.0Zinc fingerC2H2-type 4
TgeneZNF544chr7:32535414chr19:58772217ENST0000059665246464_48681716.0Zinc fingerC2H2-type 5
TgeneZNF544chr7:32535414chr19:58772217ENST0000059665246492_51481716.0Zinc fingerC2H2-type 6
TgeneZNF544chr7:32535414chr19:58772217ENST0000059665246520_54281716.0Zinc fingerC2H2-type 7
TgeneZNF544chr7:32535414chr19:58772217ENST0000059665246548_57081716.0Zinc fingerC2H2-type 8
TgeneZNF544chr7:32535414chr19:58772217ENST0000059665246576_59881716.0Zinc fingerC2H2-type 9
TgeneZNF544chr7:32535414chr19:58772217ENST0000059665246604_62681716.0Zinc fingerC2H2-type 10
TgeneZNF544chr7:32535414chr19:58772217ENST0000059665246632_65481716.0Zinc fingerC2H2-type 11
TgeneZNF544chr7:32535414chr19:58772217ENST0000059665246660_68281716.0Zinc fingerC2H2-type 12
TgeneZNF544chr7:32535414chr19:58772217ENST0000059665246688_71081716.0Zinc fingerC2H2-type 13

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneAVL9chr7:32535414chr19:58772217ENST00000318709+116173_34031649.0DomaincDENN
HgeneAVL9chr7:32535414chr19:58772217ENST00000318709+11617_16131649.0DomainuDENN
HgeneAVL9chr7:32535414chr19:58772217ENST00000318709+116342_59331649.0DomaindDENN
HgeneAVL9chr7:32535414chr19:58772217ENST00000318709+116214_23031649.0TransmembraneHelical
TgeneZNF544chr7:32535414chr19:58772217ENST000002698295714_8581716.0DomainKRAB
TgeneZNF544chr7:32535414chr19:58772217ENST000005966524614_8581716.0DomainKRAB


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Fusion Gene Sequence for AVL9-ZNF544


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>8548_8548_1_AVL9-ZNF544_AVL9_chr7_32535414_ENST00000318709_ZNF544_chr19_58772217_ENST00000594384_length(transcript)=429nt_BP=314nt
GTGTCAGGTGACAGCCCGGAAGCTGCGGAAGCGGATGAGGGAAGGGCGGCCGTGGCCCTGGGGGCGGCGGGAGCTGCTTTGCCTCCACCG
ATCTCCCTGTGCGGCCCTCATGTGCTGTGCTCGCTGACACCCGAAGTCCGCGGCTTTCCGCACACGGTGGGGTCGTCAGACCCGCTGCCC
TTGGCGGTCGAAGTCGTCGTGCGGGCCCGCGGCGGCCGCCCATGGAGAAGGCCAGGAGAGGCGGGGATGGCGTCCCCCGGGGGCCCGTAC
TGCACATCGTGGTGGTCGGATTTCACCACAAGAAGGGCTGCCAGACTGGAAAGCTACCCTTGAGGAGAATAGGTTGAATTCTGAAAAAGA

>8548_8548_1_AVL9-ZNF544_AVL9_chr7_32535414_ENST00000318709_ZNF544_chr19_58772217_ENST00000594384_length(amino acids)=91AA_BP=
MGAAGAALPPPISLCGPHVLCSLTPEVRGFPHTVGSSDPLPLAVEVVVRARGGRPWRRPGEAGMASPGGPYCTSWWSDFTTRRAARLESY

--------------------------------------------------------------
>8548_8548_2_AVL9-ZNF544_AVL9_chr7_32535414_ENST00000318709_ZNF544_chr19_58772217_ENST00000599227_length(transcript)=3108nt_BP=314nt
GTGTCAGGTGACAGCCCGGAAGCTGCGGAAGCGGATGAGGGAAGGGCGGCCGTGGCCCTGGGGGCGGCGGGAGCTGCTTTGCCTCCACCG
ATCTCCCTGTGCGGCCCTCATGTGCTGTGCTCGCTGACACCCGAAGTCCGCGGCTTTCCGCACACGGTGGGGTCGTCAGACCCGCTGCCC
TTGGCGGTCGAAGTCGTCGTGCGGGCCCGCGGCGGCCGCCCATGGAGAAGGCCAGGAGAGGCGGGGATGGCGTCCCCCGGGGGCCCGTAC
TGCACATCGTGGTGGTCGGATTTCACCACAAGAAGGGCTGCCAGACTGGAAAGCTACCCTTGAGGAGAATAGGTTGAATTCTGAAAAAGA
TCGAGCTAGGGAAGAACTATCCCACCACGTGGAAGTGTACAGGAGTGGACCGGAGGAGCCACCCTCTTTGGTATTAGGAAAAGTGCAAGA
TCAGAGCAACCAGTTAAGGGAACACCAGGAGAACTCCTTGAGGTTCATGGTACTCACCTCAGAGAGACTGTTTGCTCAAAGGGAACATTG
TGAGCTTGAACTTGGGGGAGGTTATTCTCTACCTTCTACTTTAAGCCTTCTACCTACAACATTACCTACAAGTACAGGTTTCCCTAAGCC
CAACTCACAAGTTAAAGAGTTGAAACAAAATTCAGCTTTCATTAATCATGAGAAAAATGGAGCAGATGGGAAGCACTGTGAGAGTCATCA
GTGTGCTAGAGCTTTCTGTCAGAGTATTTACTTGAGTAAACTTGGAAACGTTGAAACAGGAAAGAAAAACCCTTATGAATATATTGTCAG
TGGTGACTCTCTCAACTATGGTTCCTCCCTTTGTTTTCATGGTAGAACTTTTTCAGTGAAGAAAAGTGATGACTGTAAGGATTATGGAAA
CCTCTTCAGTCACAGTGTGTCTCTGAATGAACAGAAGCCAGTGCATTTTGGGAAAAGTCAGTATGAGTGTGATGAGTGCAGGGAAACCTG
TTCTGAGAGTCTGTGCCTTGTACAAACAGAAAGAAGTGGCCCTGGAGAGACCCCCTTCAGATGTGAGGAACGCTGTGCTGCCTTCCCCAT
GGCCTCATCTTTTTCTGACTGTAACATCATTCAGACTACAGAGAAGCCATCTGTGTGTAATCAGTGTGGAAAATCTTTCAGCTGTTGTAA
GCTCATACACCAGAGAACACACACTGGAGAAAAGCCCTTCGAATGTACTCAGTGTGGGAAATCTTTTAGCCAGAGCTATGACCTTGTCAT
ACATCAGAGGACACACACTGGAGAGAAGCCCTATGAGTGTGACCTGTGTGGGAAATCCTTCACCCAGAGATCCAAACTTATTACACATCA
GCGAATTCACACTGGAGAAAAACCGTATCAGTGTATTGAATGCAGAAAATCCTTCAGGTGGAACTCTAACCTCATTGTACATCAGAGAAT
TCATACTGGAGAGAAACCGTATGAGTGCACTCACTGTGGAAAGTCCTTCAGCCAAAGCTATGAGTTAGTTACACATAAAAGAACGCACAC
TGGAGAAAAACCCTTCAAATGTACTCAGTGTGGGAAATCTTTCAGCCAGAAGTATGACCTTGTTGTACATCAGAGGACACACACTGGAGA
GAAGCCCTATGAGTGCAACCTGTGTGGGAAATCCTTCTCCCAGAGTTCCAAACTTATTACGCATCAGCGAATTCACACTGGAGAAAAACC
GTATCAGTGTATTGAATGTGGGAAATCCTTCAGATGGAACTCTAACCTCGTCATACATCAGAGAATTCATACTGGAGAGAAACCGTACGA
TTGCACTCACTGTGGAAAGTCCTTCAGCCAAAGCTATCAGTTAGTTGCACATAAAAGAACTCACACTGGAGAAAAGCCCTATGAATGTAA
CGAGTGTGGAAAAGCCTTCAATCGAAGCACTCAGCTCATCAGGCATCTGCAAATTCACACTGGGGAGAAGCCGTACAAATGCAATCAGTG
CAATAAAGCCTTTGCAAGGAGCTCCTACCTTGTGATGCATCAGAGAACTCACACTGGTGAGAAACCTTTTGAGTGTAGTCAGTGTGGGAA
AGCCTTTTCAGGGAGCTCTAACCTTCTTTCCCATCACAGAATTCATTCTGGAGAGAAACCCTATGAATGTAGTGACTGTGGGAAATCCTT
CCGGCAGCAATCTCAACTTGTAGTGCATCGGCGGACACATACTGGAGAGAAACCTTAGGAGTGCAGTCATTGTGGGAAAGCTTTCATCCA
GAGGTCTCCCCTCATCATGCACCAGAGGACGCATGTCGGTGGGAAGAGCTATCAGTGTGACGTGTATTAAGCCAGCGGTTGTGACTCATT
GAACATCAGAGGACATATCCTGGAGAAAAGCCCTACGAATGCATTGATTGTGGGAAAGCCTTCAATGATCGCTCAACCCTTAGTAAACAC
GAGAGGACACACACTGGAGGCAAACCCTATGAATGTGACCATTGCGAGAAAGCCTTTAGCCAACGGTGTCAACTTACTAGGCAGCAGAGA
ATTCATACTGGAGAGAAGCCCTGTGAATGTTAACAAATGTGGAAAAGCTTCCAGTTATGATACTTTCCTTATTCAACATGAGAAAGCTCA
TGGGCAAGAAACTCTATGAATAACCAAGATGGAGCCGGGTGCAGTTGCCAACACTTGTAATCCCAGCAGTTTGCGAGGCCGAGGCAGGTG
GATCACTTGAGCCCAGGAGTTTGAAACCAGCCTGGGTAACATGGCAAAATCCTGTCTTTACAAAAAATACAAAAATTAGCCTAGCATGGT
GGCGCATACCTGTAGTCCTAGCTACTCAGGAGGCTGAGGTGGGAGGATCACTTGAGCTTGGGAGGCGGTGGTTGCAGTGAGCTGTGATCA
TGCCATCACACCGCTGCCTTGTGAGAGATTGAGACACTCTAAATAAATAATAACCAAGATGGGAAATTTCCCTGCCAGACCTTGTTTACT
AGAAATCAGGTGGCCAAAACATGACTCTCAGAGTGGGGCTTCATGACCATGTGCATCAGAATTGCCTGGAGTGTGCACTGAAACTGTGTA

>8548_8548_2_AVL9-ZNF544_AVL9_chr7_32535414_ENST00000318709_ZNF544_chr19_58772217_ENST00000599227_length(amino acids)=636AA_BP=290
MPDWKATLEENRLNSEKDRAREELSHHVEVYRSGPEEPPSLVLGKVQDQSNQLREHQENSLRFMVLTSERLFAQREHCELELGGGYSLPS
TLSLLPTTLPTSTGFPKPNSQVKELKQNSAFINHEKNGADGKHCESHQCARAFCQSIYLSKLGNVETGKKNPYEYIVSGDSLNYGSSLCF
HGRTFSVKKSDDCKDYGNLFSHSVSLNEQKPVHFGKSQYECDECRETCSESLCLVQTERSGPGETPFRCEERCAAFPMASSFSDCNIIQT
TEKPSVCNQCGKSFSCCKLIHQRTHTGEKPFECTQCGKSFSQSYDLVIHQRTHTGEKPYECDLCGKSFTQRSKLITHQRIHTGEKPYQCI
ECRKSFRWNSNLIVHQRIHTGEKPYECTHCGKSFSQSYELVTHKRTHTGEKPFKCTQCGKSFSQKYDLVVHQRTHTGEKPYECNLCGKSF
SQSSKLITHQRIHTGEKPYQCIECGKSFRWNSNLVIHQRIHTGEKPYDCTHCGKSFSQSYQLVAHKRTHTGEKPYECNECGKAFNRSTQL
IRHLQIHTGEKPYKCNQCNKAFARSSYLVMHQRTHTGEKPFECSQCGKAFSGSSNLLSHHRIHSGEKPYECSDCGKSFRQQSQLVVHRRT

--------------------------------------------------------------
>8548_8548_3_AVL9-ZNF544_AVL9_chr7_32535414_ENST00000404479_ZNF544_chr19_58772217_ENST00000594384_length(transcript)=208nt_BP=93nt
ATGGAGAAGGCCAGGAGAGGCGGGGATGGCGTCCCCCGGGGGCCCGTACTGCACATCGTGGTGGTCGGATTTCACCACAAGAAGGGCTGC
CAGACTGGAAAGCTACCCTTGAGGAGAATAGGTTGAATTCTGAAAAAGATCGAGCTAGGGAAGAACTATCCCACCACGTGGAAGTGTACA

>8548_8548_3_AVL9-ZNF544_AVL9_chr7_32535414_ENST00000404479_ZNF544_chr19_58772217_ENST00000594384_length(amino acids)=60AA_BP=1

--------------------------------------------------------------
>8548_8548_4_AVL9-ZNF544_AVL9_chr7_32535414_ENST00000404479_ZNF544_chr19_58772217_ENST00000599227_length(transcript)=2887nt_BP=93nt
ATGGAGAAGGCCAGGAGAGGCGGGGATGGCGTCCCCCGGGGGCCCGTACTGCACATCGTGGTGGTCGGATTTCACCACAAGAAGGGCTGC
CAGACTGGAAAGCTACCCTTGAGGAGAATAGGTTGAATTCTGAAAAAGATCGAGCTAGGGAAGAACTATCCCACCACGTGGAAGTGTACA
GGAGTGGACCGGAGGAGCCACCCTCTTTGGTATTAGGAAAAGTGCAAGATCAGAGCAACCAGTTAAGGGAACACCAGGAGAACTCCTTGA
GGTTCATGGTACTCACCTCAGAGAGACTGTTTGCTCAAAGGGAACATTGTGAGCTTGAACTTGGGGGAGGTTATTCTCTACCTTCTACTT
TAAGCCTTCTACCTACAACATTACCTACAAGTACAGGTTTCCCTAAGCCCAACTCACAAGTTAAAGAGTTGAAACAAAATTCAGCTTTCA
TTAATCATGAGAAAAATGGAGCAGATGGGAAGCACTGTGAGAGTCATCAGTGTGCTAGAGCTTTCTGTCAGAGTATTTACTTGAGTAAAC
TTGGAAACGTTGAAACAGGAAAGAAAAACCCTTATGAATATATTGTCAGTGGTGACTCTCTCAACTATGGTTCCTCCCTTTGTTTTCATG
GTAGAACTTTTTCAGTGAAGAAAAGTGATGACTGTAAGGATTATGGAAACCTCTTCAGTCACAGTGTGTCTCTGAATGAACAGAAGCCAG
TGCATTTTGGGAAAAGTCAGTATGAGTGTGATGAGTGCAGGGAAACCTGTTCTGAGAGTCTGTGCCTTGTACAAACAGAAAGAAGTGGCC
CTGGAGAGACCCCCTTCAGATGTGAGGAACGCTGTGCTGCCTTCCCCATGGCCTCATCTTTTTCTGACTGTAACATCATTCAGACTACAG
AGAAGCCATCTGTGTGTAATCAGTGTGGAAAATCTTTCAGCTGTTGTAAGCTCATACACCAGAGAACACACACTGGAGAAAAGCCCTTCG
AATGTACTCAGTGTGGGAAATCTTTTAGCCAGAGCTATGACCTTGTCATACATCAGAGGACACACACTGGAGAGAAGCCCTATGAGTGTG
ACCTGTGTGGGAAATCCTTCACCCAGAGATCCAAACTTATTACACATCAGCGAATTCACACTGGAGAAAAACCGTATCAGTGTATTGAAT
GCAGAAAATCCTTCAGGTGGAACTCTAACCTCATTGTACATCAGAGAATTCATACTGGAGAGAAACCGTATGAGTGCACTCACTGTGGAA
AGTCCTTCAGCCAAAGCTATGAGTTAGTTACACATAAAAGAACGCACACTGGAGAAAAACCCTTCAAATGTACTCAGTGTGGGAAATCTT
TCAGCCAGAAGTATGACCTTGTTGTACATCAGAGGACACACACTGGAGAGAAGCCCTATGAGTGCAACCTGTGTGGGAAATCCTTCTCCC
AGAGTTCCAAACTTATTACGCATCAGCGAATTCACACTGGAGAAAAACCGTATCAGTGTATTGAATGTGGGAAATCCTTCAGATGGAACT
CTAACCTCGTCATACATCAGAGAATTCATACTGGAGAGAAACCGTACGATTGCACTCACTGTGGAAAGTCCTTCAGCCAAAGCTATCAGT
TAGTTGCACATAAAAGAACTCACACTGGAGAAAAGCCCTATGAATGTAACGAGTGTGGAAAAGCCTTCAATCGAAGCACTCAGCTCATCA
GGCATCTGCAAATTCACACTGGGGAGAAGCCGTACAAATGCAATCAGTGCAATAAAGCCTTTGCAAGGAGCTCCTACCTTGTGATGCATC
AGAGAACTCACACTGGTGAGAAACCTTTTGAGTGTAGTCAGTGTGGGAAAGCCTTTTCAGGGAGCTCTAACCTTCTTTCCCATCACAGAA
TTCATTCTGGAGAGAAACCCTATGAATGTAGTGACTGTGGGAAATCCTTCCGGCAGCAATCTCAACTTGTAGTGCATCGGCGGACACATA
CTGGAGAGAAACCTTAGGAGTGCAGTCATTGTGGGAAAGCTTTCATCCAGAGGTCTCCCCTCATCATGCACCAGAGGACGCATGTCGGTG
GGAAGAGCTATCAGTGTGACGTGTATTAAGCCAGCGGTTGTGACTCATTGAACATCAGAGGACATATCCTGGAGAAAAGCCCTACGAATG
CATTGATTGTGGGAAAGCCTTCAATGATCGCTCAACCCTTAGTAAACACGAGAGGACACACACTGGAGGCAAACCCTATGAATGTGACCA
TTGCGAGAAAGCCTTTAGCCAACGGTGTCAACTTACTAGGCAGCAGAGAATTCATACTGGAGAGAAGCCCTGTGAATGTTAACAAATGTG
GAAAAGCTTCCAGTTATGATACTTTCCTTATTCAACATGAGAAAGCTCATGGGCAAGAAACTCTATGAATAACCAAGATGGAGCCGGGTG
CAGTTGCCAACACTTGTAATCCCAGCAGTTTGCGAGGCCGAGGCAGGTGGATCACTTGAGCCCAGGAGTTTGAAACCAGCCTGGGTAACA
TGGCAAAATCCTGTCTTTACAAAAAATACAAAAATTAGCCTAGCATGGTGGCGCATACCTGTAGTCCTAGCTACTCAGGAGGCTGAGGTG
GGAGGATCACTTGAGCTTGGGAGGCGGTGGTTGCAGTGAGCTGTGATCATGCCATCACACCGCTGCCTTGTGAGAGATTGAGACACTCTA
AATAAATAATAACCAAGATGGGAAATTTCCCTGCCAGACCTTGTTTACTAGAAATCAGGTGGCCAAAACATGACTCTCAGAGTGGGGCTT
CATGACCATGTGCATCAGAATTGCCTGGAGTGTGCACTGAAACTGTGTATTACCAAGCTCACTCTAGCCAACTAAATAAAAATCTCTGGC

>8548_8548_4_AVL9-ZNF544_AVL9_chr7_32535414_ENST00000404479_ZNF544_chr19_58772217_ENST00000599227_length(amino acids)=636AA_BP=290
MPDWKATLEENRLNSEKDRAREELSHHVEVYRSGPEEPPSLVLGKVQDQSNQLREHQENSLRFMVLTSERLFAQREHCELELGGGYSLPS
TLSLLPTTLPTSTGFPKPNSQVKELKQNSAFINHEKNGADGKHCESHQCARAFCQSIYLSKLGNVETGKKNPYEYIVSGDSLNYGSSLCF
HGRTFSVKKSDDCKDYGNLFSHSVSLNEQKPVHFGKSQYECDECRETCSESLCLVQTERSGPGETPFRCEERCAAFPMASSFSDCNIIQT
TEKPSVCNQCGKSFSCCKLIHQRTHTGEKPFECTQCGKSFSQSYDLVIHQRTHTGEKPYECDLCGKSFTQRSKLITHQRIHTGEKPYQCI
ECRKSFRWNSNLIVHQRIHTGEKPYECTHCGKSFSQSYELVTHKRTHTGEKPFKCTQCGKSFSQKYDLVVHQRTHTGEKPYECNLCGKSF
SQSSKLITHQRIHTGEKPYQCIECGKSFRWNSNLVIHQRIHTGEKPYDCTHCGKSFSQSYQLVAHKRTHTGEKPYECNECGKAFNRSTQL
IRHLQIHTGEKPYKCNQCNKAFARSSYLVMHQRTHTGEKPFECSQCGKAFSGSSNLLSHHRIHSGEKPYECSDCGKSFRQQSQLVVHRRT

--------------------------------------------------------------
>8548_8548_5_AVL9-ZNF544_AVL9_chr7_32535414_ENST00000409301_ZNF544_chr19_58772217_ENST00000594384_length(transcript)=392nt_BP=277nt
AGGGAAGGGCGGCCGTGGCCCTGGGGGCGGCGGGAGCTGCTTTGCCTCCACCGATCTCCCTGTGCGGCCCTCATGTGCTGTGCTCGCTGA
CACCCGAAGTCCGCGGCTTTCCGCACACGGTGGGGTCGTCAGACCCGCTGCCCTTGGCGGTCGAAGTCGTCGTGCGGGCCCGCGGCGGCC
GCCCATGGAGAAGGCCAGGAGAGGCGGGGATGGCGTCCCCCGGGGGCCCGTACTGCACATCGTGGTGGTCGGATTTCACCACAAGAAGGG
CTGCCAGACTGGAAAGCTACCCTTGAGGAGAATAGGTTGAATTCTGAAAAAGATCGAGCTAGGGAAGAACTATCCCACCACGTGGAAGTG

>8548_8548_5_AVL9-ZNF544_AVL9_chr7_32535414_ENST00000409301_ZNF544_chr19_58772217_ENST00000594384_length(amino acids)=91AA_BP=
MGAAGAALPPPISLCGPHVLCSLTPEVRGFPHTVGSSDPLPLAVEVVVRARGGRPWRRPGEAGMASPGGPYCTSWWSDFTTRRAARLESY

--------------------------------------------------------------
>8548_8548_6_AVL9-ZNF544_AVL9_chr7_32535414_ENST00000409301_ZNF544_chr19_58772217_ENST00000599227_length(transcript)=3071nt_BP=277nt
AGGGAAGGGCGGCCGTGGCCCTGGGGGCGGCGGGAGCTGCTTTGCCTCCACCGATCTCCCTGTGCGGCCCTCATGTGCTGTGCTCGCTGA
CACCCGAAGTCCGCGGCTTTCCGCACACGGTGGGGTCGTCAGACCCGCTGCCCTTGGCGGTCGAAGTCGTCGTGCGGGCCCGCGGCGGCC
GCCCATGGAGAAGGCCAGGAGAGGCGGGGATGGCGTCCCCCGGGGGCCCGTACTGCACATCGTGGTGGTCGGATTTCACCACAAGAAGGG
CTGCCAGACTGGAAAGCTACCCTTGAGGAGAATAGGTTGAATTCTGAAAAAGATCGAGCTAGGGAAGAACTATCCCACCACGTGGAAGTG
TACAGGAGTGGACCGGAGGAGCCACCCTCTTTGGTATTAGGAAAAGTGCAAGATCAGAGCAACCAGTTAAGGGAACACCAGGAGAACTCC
TTGAGGTTCATGGTACTCACCTCAGAGAGACTGTTTGCTCAAAGGGAACATTGTGAGCTTGAACTTGGGGGAGGTTATTCTCTACCTTCT
ACTTTAAGCCTTCTACCTACAACATTACCTACAAGTACAGGTTTCCCTAAGCCCAACTCACAAGTTAAAGAGTTGAAACAAAATTCAGCT
TTCATTAATCATGAGAAAAATGGAGCAGATGGGAAGCACTGTGAGAGTCATCAGTGTGCTAGAGCTTTCTGTCAGAGTATTTACTTGAGT
AAACTTGGAAACGTTGAAACAGGAAAGAAAAACCCTTATGAATATATTGTCAGTGGTGACTCTCTCAACTATGGTTCCTCCCTTTGTTTT
CATGGTAGAACTTTTTCAGTGAAGAAAAGTGATGACTGTAAGGATTATGGAAACCTCTTCAGTCACAGTGTGTCTCTGAATGAACAGAAG
CCAGTGCATTTTGGGAAAAGTCAGTATGAGTGTGATGAGTGCAGGGAAACCTGTTCTGAGAGTCTGTGCCTTGTACAAACAGAAAGAAGT
GGCCCTGGAGAGACCCCCTTCAGATGTGAGGAACGCTGTGCTGCCTTCCCCATGGCCTCATCTTTTTCTGACTGTAACATCATTCAGACT
ACAGAGAAGCCATCTGTGTGTAATCAGTGTGGAAAATCTTTCAGCTGTTGTAAGCTCATACACCAGAGAACACACACTGGAGAAAAGCCC
TTCGAATGTACTCAGTGTGGGAAATCTTTTAGCCAGAGCTATGACCTTGTCATACATCAGAGGACACACACTGGAGAGAAGCCCTATGAG
TGTGACCTGTGTGGGAAATCCTTCACCCAGAGATCCAAACTTATTACACATCAGCGAATTCACACTGGAGAAAAACCGTATCAGTGTATT
GAATGCAGAAAATCCTTCAGGTGGAACTCTAACCTCATTGTACATCAGAGAATTCATACTGGAGAGAAACCGTATGAGTGCACTCACTGT
GGAAAGTCCTTCAGCCAAAGCTATGAGTTAGTTACACATAAAAGAACGCACACTGGAGAAAAACCCTTCAAATGTACTCAGTGTGGGAAA
TCTTTCAGCCAGAAGTATGACCTTGTTGTACATCAGAGGACACACACTGGAGAGAAGCCCTATGAGTGCAACCTGTGTGGGAAATCCTTC
TCCCAGAGTTCCAAACTTATTACGCATCAGCGAATTCACACTGGAGAAAAACCGTATCAGTGTATTGAATGTGGGAAATCCTTCAGATGG
AACTCTAACCTCGTCATACATCAGAGAATTCATACTGGAGAGAAACCGTACGATTGCACTCACTGTGGAAAGTCCTTCAGCCAAAGCTAT
CAGTTAGTTGCACATAAAAGAACTCACACTGGAGAAAAGCCCTATGAATGTAACGAGTGTGGAAAAGCCTTCAATCGAAGCACTCAGCTC
ATCAGGCATCTGCAAATTCACACTGGGGAGAAGCCGTACAAATGCAATCAGTGCAATAAAGCCTTTGCAAGGAGCTCCTACCTTGTGATG
CATCAGAGAACTCACACTGGTGAGAAACCTTTTGAGTGTAGTCAGTGTGGGAAAGCCTTTTCAGGGAGCTCTAACCTTCTTTCCCATCAC
AGAATTCATTCTGGAGAGAAACCCTATGAATGTAGTGACTGTGGGAAATCCTTCCGGCAGCAATCTCAACTTGTAGTGCATCGGCGGACA
CATACTGGAGAGAAACCTTAGGAGTGCAGTCATTGTGGGAAAGCTTTCATCCAGAGGTCTCCCCTCATCATGCACCAGAGGACGCATGTC
GGTGGGAAGAGCTATCAGTGTGACGTGTATTAAGCCAGCGGTTGTGACTCATTGAACATCAGAGGACATATCCTGGAGAAAAGCCCTACG
AATGCATTGATTGTGGGAAAGCCTTCAATGATCGCTCAACCCTTAGTAAACACGAGAGGACACACACTGGAGGCAAACCCTATGAATGTG
ACCATTGCGAGAAAGCCTTTAGCCAACGGTGTCAACTTACTAGGCAGCAGAGAATTCATACTGGAGAGAAGCCCTGTGAATGTTAACAAA
TGTGGAAAAGCTTCCAGTTATGATACTTTCCTTATTCAACATGAGAAAGCTCATGGGCAAGAAACTCTATGAATAACCAAGATGGAGCCG
GGTGCAGTTGCCAACACTTGTAATCCCAGCAGTTTGCGAGGCCGAGGCAGGTGGATCACTTGAGCCCAGGAGTTTGAAACCAGCCTGGGT
AACATGGCAAAATCCTGTCTTTACAAAAAATACAAAAATTAGCCTAGCATGGTGGCGCATACCTGTAGTCCTAGCTACTCAGGAGGCTGA
GGTGGGAGGATCACTTGAGCTTGGGAGGCGGTGGTTGCAGTGAGCTGTGATCATGCCATCACACCGCTGCCTTGTGAGAGATTGAGACAC
TCTAAATAAATAATAACCAAGATGGGAAATTTCCCTGCCAGACCTTGTTTACTAGAAATCAGGTGGCCAAAACATGACTCTCAGAGTGGG
GCTTCATGACCATGTGCATCAGAATTGCCTGGAGTGTGCACTGAAACTGTGTATTACCAAGCTCACTCTAGCCAACTAAATAAAAATCTC

>8548_8548_6_AVL9-ZNF544_AVL9_chr7_32535414_ENST00000409301_ZNF544_chr19_58772217_ENST00000599227_length(amino acids)=636AA_BP=290
MPDWKATLEENRLNSEKDRAREELSHHVEVYRSGPEEPPSLVLGKVQDQSNQLREHQENSLRFMVLTSERLFAQREHCELELGGGYSLPS
TLSLLPTTLPTSTGFPKPNSQVKELKQNSAFINHEKNGADGKHCESHQCARAFCQSIYLSKLGNVETGKKNPYEYIVSGDSLNYGSSLCF
HGRTFSVKKSDDCKDYGNLFSHSVSLNEQKPVHFGKSQYECDECRETCSESLCLVQTERSGPGETPFRCEERCAAFPMASSFSDCNIIQT
TEKPSVCNQCGKSFSCCKLIHQRTHTGEKPFECTQCGKSFSQSYDLVIHQRTHTGEKPYECDLCGKSFTQRSKLITHQRIHTGEKPYQCI
ECRKSFRWNSNLIVHQRIHTGEKPYECTHCGKSFSQSYELVTHKRTHTGEKPFKCTQCGKSFSQKYDLVVHQRTHTGEKPYECNLCGKSF
SQSSKLITHQRIHTGEKPYQCIECGKSFRWNSNLVIHQRIHTGEKPYDCTHCGKSFSQSYQLVAHKRTHTGEKPYECNECGKAFNRSTQL
IRHLQIHTGEKPYKCNQCNKAFARSSYLVMHQRTHTGEKPFECSQCGKAFSGSSNLLSHHRIHSGEKPYECSDCGKSFRQQSQLVVHRRT

--------------------------------------------------------------

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Fusion Gene PPI Analysis for AVL9-ZNF544


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for AVL9-ZNF544


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for AVL9-ZNF544


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneAVL9C0087031Juvenile-Onset Still Disease1CTD_human
HgeneAVL9C3495559Juvenile arthritis1CTD_human
HgeneAVL9C3714758Juvenile psoriatic arthritis1CTD_human
HgeneAVL9C4552091Polyarthritis, Juvenile, Rheumatoid Factor Negative1CTD_human
HgeneAVL9C4704862Polyarthritis, Juvenile, Rheumatoid Factor Positive1CTD_human