|
||||||
|
 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:TAB2-PPP1R14C (FusionGDB2 ID:HG23118TG81706) |
Fusion Gene Summary for TAB2-PPP1R14C |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: TAB2-PPP1R14C | Fusion gene ID: hg23118tg81706 | Hgene | Tgene | Gene symbol | TAB2 | PPP1R14C | Gene ID | 23118 | 81706 |
| Gene name | TGF-beta activated kinase 1 (MAP3K7) binding protein 2 | protein phosphatase 1 regulatory inhibitor subunit 14C | |
| Synonyms | CHTD2|MAP3K7IP2|TAB-2 | CPI17-like|KEPI|NY-BR-81 | |
| Cytomap | ('TAB2')('PPP1R14C') 6q25.1 | 6q25.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | TGF-beta-activated kinase 1 and MAP3K7-binding protein 2TAK1-binding protein 2mitogen-activated protein kinase kinase kinase 7-interacting protein 2 | protein phosphatase 1 regulatory subunit 14CPKC-potentiated PP1 inhibitory proteinkinase C-enhanced PP1 inhibitorkinase-enhanced PP1 inhibitorserologically defined breast cancer antigen NY-BR-81 | |
| Modification date | 20200315 | 20200313 | |
| UniProtAcc | . | . | |
| Ensembl transtripts involved in fusion gene | ENST00000286332, ENST00000367456, ENST00000536230, ENST00000538427, ENST00000392282, ENST00000461481, | ||
| Fusion gene scores | * DoF score | 20 X 17 X 5=1700 | 3 X 2 X 3=18 |
| # samples | 19 | 3 | |
| ** MAII score | log2(19/1700*10)=-3.16146342269412 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: TAB2 [Title/Abstract] AND PPP1R14C [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | TAB2(149718900)-PPP1R14C(150535880), # samples:1 | ||
| Anticipated loss of major functional domain due to fusion event. | TAB2-PPP1R14C seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. TAB2-PPP1R14C seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. TAB2-PPP1R14C seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. TAB2-PPP1R14C seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | TAB2 | GO:0032496 | response to lipopolysaccharide | 19193853 |
| Hgene | TAB2 | GO:0045860 | positive regulation of protein kinase activity | 11460167 |
| Fusion gene breakpoints across TAB2 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
 |
| Fusion gene breakpoints across PPP1R14C (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
 |
| Fusion gene information * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | BLCA | TCGA-ZF-AA51-01A | TAB2 | chr6 | 149718900 | + | PPP1R14C | chr6 | 150535880 | + |
Top |
Fusion Gene ORF analysis for TAB2-PPP1R14C |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000286332 | ENST00000361131 | TAB2 | chr6 | 149718900 | + | PPP1R14C | chr6 | 150535880 | + |
| In-frame | ENST00000367456 | ENST00000361131 | TAB2 | chr6 | 149718900 | + | PPP1R14C | chr6 | 150535880 | + |
| In-frame | ENST00000536230 | ENST00000361131 | TAB2 | chr6 | 149718900 | + | PPP1R14C | chr6 | 150535880 | + |
| In-frame | ENST00000538427 | ENST00000361131 | TAB2 | chr6 | 149718900 | + | PPP1R14C | chr6 | 150535880 | + |
| intron-3CDS | ENST00000392282 | ENST00000361131 | TAB2 | chr6 | 149718900 | + | PPP1R14C | chr6 | 150535880 | + |
| intron-3CDS | ENST00000461481 | ENST00000361131 | TAB2 | chr6 | 149718900 | + | PPP1R14C | chr6 | 150535880 | + |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000536230 | TAB2 | chr6 | 149718900 | + | ENST00000361131 | PPP1R14C | chr6 | 150535880 | + | 3527 | 1798 | 124 | 1989 | 621 |
| ENST00000538427 | TAB2 | chr6 | 149718900 | + | ENST00000361131 | PPP1R14C | chr6 | 150535880 | + | 3899 | 2170 | 406 | 2361 | 651 |
| ENST00000367456 | TAB2 | chr6 | 149718900 | + | ENST00000361131 | PPP1R14C | chr6 | 150535880 | + | 4070 | 2341 | 577 | 2532 | 651 |
| ENST00000286332 | TAB2 | chr6 | 149718900 | + | ENST00000361131 | PPP1R14C | chr6 | 150535880 | + | 3583 | 1854 | 90 | 2045 | 651 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000536230 | ENST00000361131 | TAB2 | chr6 | 149718900 | + | PPP1R14C | chr6 | 150535880 | + | 0.000454012 | 0.999546 |
| ENST00000538427 | ENST00000361131 | TAB2 | chr6 | 149718900 | + | PPP1R14C | chr6 | 150535880 | + | 0.000385919 | 0.99961406 |
| ENST00000367456 | ENST00000361131 | TAB2 | chr6 | 149718900 | + | PPP1R14C | chr6 | 150535880 | + | 0.00033411 | 0.99966586 |
| ENST00000286332 | ENST00000361131 | TAB2 | chr6 | 149718900 | + | PPP1R14C | chr6 | 150535880 | + | 0.000377071 | 0.99962294 |
Top |
Fusion Genomic Features for TAB2-PPP1R14C |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| TAB2 | chr6 | 149718900 | + | PPP1R14C | chr6 | 150535879 | + | 0.016711762 | 0.9832882 |
| TAB2 | chr6 | 149718900 | + | PPP1R14C | chr6 | 150535879 | + | 0.016711762 | 0.9832882 |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
 |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
 |
Top |
Fusion Protein Features for TAB2-PPP1R14C |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr6:149718900/chr6:150535880) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| . | . |
| FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. | FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | TAB2 | chr6:149718900 | chr6:150535880 | ENST00000286332 | + | 3 | 6 | 8_51 | 588 | 694.0 | Domain | CUE |
| Hgene | TAB2 | chr6:149718900 | chr6:150535880 | ENST00000367456 | + | 5 | 8 | 8_51 | 588 | 694.0 | Domain | CUE |
| Hgene | TAB2 | chr6:149718900 | chr6:150535880 | ENST00000538427 | + | 5 | 8 | 8_51 | 588 | 694.0 | Domain | CUE |
| Tgene | PPP1R14C | chr6:149718900 | chr6:150535880 | ENST00000361131 | 0 | 4 | 102_105 | 102 | 166.0 | Compositional bias | Note=Poly-Glu |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | TAB2 | chr6:149718900 | chr6:150535880 | ENST00000286332 | + | 3 | 6 | 532_619 | 588 | 694.0 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | TAB2 | chr6:149718900 | chr6:150535880 | ENST00000367456 | + | 5 | 8 | 532_619 | 588 | 694.0 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | TAB2 | chr6:149718900 | chr6:150535880 | ENST00000392282 | + | 1 | 4 | 532_619 | 0 | 537.0 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | TAB2 | chr6:149718900 | chr6:150535880 | ENST00000538427 | + | 5 | 8 | 532_619 | 588 | 694.0 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | TAB2 | chr6:149718900 | chr6:150535880 | ENST00000392282 | + | 1 | 4 | 8_51 | 0 | 537.0 | Domain | CUE |
| Hgene | TAB2 | chr6:149718900 | chr6:150535880 | ENST00000286332 | + | 3 | 6 | 663_693 | 588 | 694.0 | Zinc finger | RanBP2-type |
| Hgene | TAB2 | chr6:149718900 | chr6:150535880 | ENST00000367456 | + | 5 | 8 | 663_693 | 588 | 694.0 | Zinc finger | RanBP2-type |
| Hgene | TAB2 | chr6:149718900 | chr6:150535880 | ENST00000392282 | + | 1 | 4 | 663_693 | 0 | 537.0 | Zinc finger | RanBP2-type |
| Hgene | TAB2 | chr6:149718900 | chr6:150535880 | ENST00000538427 | + | 5 | 8 | 663_693 | 588 | 694.0 | Zinc finger | RanBP2-type |
| Tgene | PPP1R14C | chr6:149718900 | chr6:150535880 | ENST00000361131 | 0 | 4 | 51_56 | 102 | 166.0 | Compositional bias | Note=Poly-Ala | |
| Tgene | PPP1R14C | chr6:149718900 | chr6:150535880 | ENST00000361131 | 0 | 4 | 58_64 | 102 | 166.0 | Compositional bias | Note=Poly-Gln |
Top |
Fusion Gene Sequence for TAB2-PPP1R14C |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >88633_88633_1_TAB2-PPP1R14C_TAB2_chr6_149718900_ENST00000286332_PPP1R14C_chr6_150535880_ENST00000361131_length(transcript)=3583nt_BP=1854nt GAAAATGCTTGGACAGAAGAGATGAGTACTATTTCCACTAAGGCCTAGAATTGCCTACTGTACAAATAGTCCTGATCAGGCAATATACGA ATGGCCCAAGGAAGCCACCAAATTGATTTTCAGGTTTTACATGACCTGCGACAAAAATTCCCTGAAGTACCTGAAGTTGTTGTATCCAGG TGCATGTTACAGAATAATAATAACCTGGATGCCTGCTGTGCTGTTCTCTCTCAGGAGAGTACAAGATATCTTTATGGTGAAGGAGACTTG AATTTTTCAGATGATTCTGGAATTTCTGGTCTACGCAATCACATGACTTCTCTCAACTTGGACTTGCAATCACAGAACATTTACCACCAT GGAAGAGAAGGAAGTAGGATGAATGGAAGTAGGACTCTAACGCACAGCATTAGTGATGGACAACTTCAAGGTGGCCAGTCCAATAGTGAA CTATTTCAGCAGGAGCCACAGACAGCACCAGCTCAAGTTCCTCAAGGCTTTAATGTTTTTGGAATGTCCAGTTCCTCTGGTGCTTCAAAT TCAGCACCACATCTTGGATTTCACTTAGGCAGCAAAGGAACATCTAGCCTTTCTCAACAAACTCCCAGATTTAATCCCATTATGGTAACT TTAGCCCCAAATATCCAGACTGGTCGTAATACTCCTACATCTTTGCACATACATGGTGTACCTCCACCTGTACTTAACAGTCCACAGGGA AATTCTATCTATATTAGGCCTTACATTACAACTCCTGGTGGTACAACTCGACAGACACAACAGCATTCTGGCTGGGTATCTCAGTTTAAT CCCATGAACCCTCAGCAAGTTTATCAGCCTTCACAGCCTGGTCCCTGGACTACTTGTCCTGCATCTAATCCTCTGTCACATACCTCATCT CAACAGCCAAATCAGCAAGGCCACCAGACCTCTCATGTCTACATGCCAATCAGTTCACCTACTACTTCACAACCACCAACCATTCATTCA TCTGGTAGCTCACAGTCTTCTGCCCATAGCCAATATAACATTCAGAATATTTCAACAGGACCTCGAAAAAACCAGATTGAAATCAAACTT GAACCCCCACAAAGAAATAATTCTTCAAAACTGCGTTCTTCTGGACCTCGAACCTCCAGCACTTCCTCTTCAGTCAATAGCCAGACCTTA AACAGAAATCAGCCCACTGTTTACATAGCTGCCAGCCCCCCAAATACGGATGAGCTGATGTCCCGTAGTCAACCTAAGGTCTATATTTCA GCGAATGCTGCCACAGGAGATGAACAGGTCATGCGGAATCAGCCCACACTCTTCATATCCACAAACTCTGGAGCATCTGCTGCCTCCAGG AACATGTCTGGGCAAGTGAGCATGGGTCCTGCCTTTATTCATCACCATCCTCCCAAAAGTCGAGCAATAGGCAATAACTCTGCAACCTCT CCTCGAGTGGTAGTCACTCAGCCCAATACGAAATACACTTTCAAAATTACAGTCTCTCCCAATAAGCCCCCTGCAGTTTCACCAGGGGTG GTGTCCCCTACCTTTGAACTTACAAATCTTCTTAATCATCCTGATCATTATGTAGAAACCGAGAATATTCAGCACCTCACGGACCCTACA TTAGCACATGTGGATAGAATAAGTGAAACACGGAAACTGAGTATGGGATCTGATGATGCTGCCTACACACAAGCTCTTTTGGTACACCAG AAGGCCAGAATGGAACGACTTCAAAGAGAACTTGAGATTCAAAAGAAAAAGCTGGATAAATTAAAATCTGAGGTTAATGAAATGGAAAAT AATCTAACTCGAAGGCGCCTGAAAAGATCAAATTCTATATCCCAGATACCTTCCGAAGAAGAAATGCCAGAGGTAGAAATTGACATTGAT GATCTTCTTGATGCAGACAGTGATGAAGAGAGAGCTTCAAAATTACAGGAAGCTCTTGTAGACTGCTACAAACCAACAGAGGAATTTATC AAAGAGCTGCTTTCTCGGATAAGAGGCATGAGGAAACTGAGCCCTCCGCAGAAGAAGAGTGTATGATTCTGGAACAGGGTGAAACTCTCC CAGAGACGAAGAAAGAGTCCTGGGATTTGTACTTCATGAAGACTTTTGTGAAAGAATAGGTGTCCTTATGAACAACGTTTTTGTTTTTTT TTTTTTCTTTTTTGGTGTGAAGGTGGGGGGGTCTATTAGACATTTATTCAAGAGCGTTCTTTTTTTGGTTTTAAAGGTTTTTGTTAATGT AATATTTTAATAGCAAAGATATCATGACTCTAGCCACAGCCTAACCAAGGATTATCAAAGGAGGTGGACACTCAAGGAAGGGCCACGCCA GGCTGCGTTTCCTGCAAGGACTCAGATGTTCAGTACCTTATGATACAGGGAAGATAGTTTTCTTACAAGTAGTTTGGTAATATTTTTTTT CTTAAGTTGTACATTTGACTCAGCTGTCAAATTTCTCACACTTGTATATATCTACACACAACTAAGTTAAAATGTTGATGTGAGTTTTAT TTCACATGGATGGAATAAACTTGTGGTTGTCCTTTAACTGGAGGTCCCAGCACATGTGTTTTCAAGAGGCCACTAGGCATTCTTCACTGA GTGCTGCTGACTTCAACGTTCACTTTATGCACCAAAGTGAAAGAATTCAGTGTATCCGTTATTTTAATGCACTACACCACAGAAATGTTA AGTTGGTCAAGGGCTTAATTTATGGAATTTCTATTATTTCATTGGTTGGGATGCTTTGCCAGGTCATGTGCTTATTGTCTCATTTTGTAG TCTTTTAAAGTTGTATGAACCCTTAATTTGAAGAACTAACTTGATTTCTAGAGAAATATCCACACTATCTCAGTGGTATTTTGCATTGGA AAAAGGAAGCACTGTGTAGCAGTGAATTGTCTGCTTTCCACCGAGTACTGTGTTTATTCTCTCTCCAGGAAAGCAGATCAAAAGAAAGTT AGCAGATCGAGTGTCTTCTTCCTTAGAAATAGGTTCTGGTAGCTTCTGTGCCTGGGTAGTATCAGACCAGTGGGAGTAAACCGAGTGTTA AGTGTCAAGGTGAGAAAGCCTCACATTCTCTCAAGACAGTTGCTCTAGGAGCTGAGTTGCTGGTTTGGAAGTGTGGAGATTGCATTTCTG GCTTCTCTCAATGGCTTGTGTTGAGGACTCTGGGTGCTCCTGGCCCTAATTGTGCACCCTGATCCCCGTGCTTGGAGCTAGGCCTGGTGG CGTGCTCTAGCCCTCTCAGTTACCAGCTCTTTGGAGAAGGATCAAAATTCAGATGGAATGTGGGATGGGTAATAGGTGAGAGTAGAAACC CTTCCCTCCAGGAGGCCCCCGCTGACTCCCACAGAAACCCACCTACCATAAGATGTCTTCAGGTGGCCTTGTCCAAGGATGGGGGTCAGG CATTTTATATCAAGGGTGCTCTGAACATATTTTATTTTTTAAAAAAACTATGTTTGTGAATTTTGCGTATACTGGCAAGCTTTTGAAAAT >88633_88633_1_TAB2-PPP1R14C_TAB2_chr6_149718900_ENST00000286332_PPP1R14C_chr6_150535880_ENST00000361131_length(amino acids)=651AA_BP=586 MAQGSHQIDFQVLHDLRQKFPEVPEVVVSRCMLQNNNNLDACCAVLSQESTRYLYGEGDLNFSDDSGISGLRNHMTSLNLDLQSQNIYHH GREGSRMNGSRTLTHSISDGQLQGGQSNSELFQQEPQTAPAQVPQGFNVFGMSSSSGASNSAPHLGFHLGSKGTSSLSQQTPRFNPIMVT LAPNIQTGRNTPTSLHIHGVPPPVLNSPQGNSIYIRPYITTPGGTTRQTQQHSGWVSQFNPMNPQQVYQPSQPGPWTTCPASNPLSHTSS QQPNQQGHQTSHVYMPISSPTTSQPPTIHSSGSSQSSAHSQYNIQNISTGPRKNQIEIKLEPPQRNNSSKLRSSGPRTSSTSSSVNSQTL NRNQPTVYIAASPPNTDELMSRSQPKVYISANAATGDEQVMRNQPTLFISTNSGASAASRNMSGQVSMGPAFIHHHPPKSRAIGNNSATS PRVVVTQPNTKYTFKITVSPNKPPAVSPGVVSPTFELTNLLNHPDHYVETENIQHLTDPTLAHVDRISETRKLSMGSDDAAYTQALLVHQ KARMERLQRELEIQKKKLDKLKSEVNEMENNLTRRRLKRSNSISQIPSEEEMPEVEIDIDDLLDADSDEERASKLQEALVDCYKPTEEFI -------------------------------------------------------------- >88633_88633_2_TAB2-PPP1R14C_TAB2_chr6_149718900_ENST00000367456_PPP1R14C_chr6_150535880_ENST00000361131_length(transcript)=4070nt_BP=2341nt GAAAAGTTTTAGGCAGCTAGGAATGTGGAGATGTGGGTAGTGGTGGCTGCCAAGCACAGGAAAATGATCATGCTGAACTGTACAAAGGAG ATTGTCTCTGAACCTTTTCATAGGTTCTGACACTCTATATATGTCATCTTATTTAAAACCCTCTGTATTAAAATGATAAGGATTTGGAGA CATTGAAATTATATAGAATTTAAATGTATGCATGTTCATATGTTTTTGCCTCTGGCTCATATTTCCAGAATACTTAACAGTATTTTAACA TTTTGTTTCTTATGATTCTGGTCCTAAAAAATCAAGGACGCTGCTTACTCAGAAAGCTAAAAAACCTGAGCTCCAGACCCAGTTCCTGGA CCTGCCCTGGAAAAGAAGTATCCCGTAGAGATGAGCTCACTGCAGTTACTTAATTAACAATTTGTAAGCTGCAAAAATGGCAATGGGCCA ACCAAGAACAGCTACAATTTGAATTTTTCTATTTCCAGAAAATGCTTGGACAGAAGAGATGAGTACTATTTCCACTAAGGCCTAGAATTG CCTACTGTACAAATAGTCCTGATCAGGCAATATACGAATGGCCCAAGGAAGCCACCAAATTGATTTTCAGGTTTTACATGACCTGCGACA AAAATTCCCTGAAGTACCTGAAGTTGTTGTATCCAGGTGCATGTTACAGAATAATAATAACCTGGATGCCTGCTGTGCTGTTCTCTCTCA GGAGAGTACAAGATATCTTTATGGTGAAGGAGACTTGAATTTTTCAGATGATTCTGGAATTTCTGGTCTACGCAATCACATGACTTCTCT CAACTTGGACTTGCAATCACAGAACATTTACCACCATGGAAGAGAAGGAAGTAGGATGAATGGAAGTAGGACTCTAACGCACAGCATTAG TGATGGACAACTTCAAGGTGGCCAGTCCAATAGTGAACTATTTCAGCAGGAGCCACAGACAGCACCAGCTCAAGTTCCTCAAGGCTTTAA TGTTTTTGGAATGTCCAGTTCCTCTGGTGCTTCAAATTCAGCACCACATCTTGGATTTCACTTAGGCAGCAAAGGAACATCTAGCCTTTC TCAACAAACTCCCAGATTTAATCCCATTATGGTAACTTTAGCCCCAAATATCCAGACTGGTCGTAATACTCCTACATCTTTGCACATACA TGGTGTACCTCCACCTGTACTTAACAGTCCACAGGGAAATTCTATCTATATTAGGCCTTACATTACAACTCCTGGTGGTACAACTCGACA GACACAACAGCATTCTGGCTGGGTATCTCAGTTTAATCCCATGAACCCTCAGCAAGTTTATCAGCCTTCACAGCCTGGTCCCTGGACTAC TTGTCCTGCATCTAATCCTCTGTCACATACCTCATCTCAACAGCCAAATCAGCAAGGCCACCAGACCTCTCATGTCTACATGCCAATCAG TTCACCTACTACTTCACAACCACCAACCATTCATTCATCTGGTAGCTCACAGTCTTCTGCCCATAGCCAATATAACATTCAGAATATTTC AACAGGACCTCGAAAAAACCAGATTGAAATCAAACTTGAACCCCCACAAAGAAATAATTCTTCAAAACTGCGTTCTTCTGGACCTCGAAC CTCCAGCACTTCCTCTTCAGTCAATAGCCAGACCTTAAACAGAAATCAGCCCACTGTTTACATAGCTGCCAGCCCCCCAAATACGGATGA GCTGATGTCCCGTAGTCAACCTAAGGTCTATATTTCAGCGAATGCTGCCACAGGAGATGAACAGGTCATGCGGAATCAGCCCACACTCTT CATATCCACAAACTCTGGAGCATCTGCTGCCTCCAGGAACATGTCTGGGCAAGTGAGCATGGGTCCTGCCTTTATTCATCACCATCCTCC CAAAAGTCGAGCAATAGGCAATAACTCTGCAACCTCTCCTCGAGTGGTAGTCACTCAGCCCAATACGAAATACACTTTCAAAATTACAGT CTCTCCCAATAAGCCCCCTGCAGTTTCACCAGGGGTGGTGTCCCCTACCTTTGAACTTACAAATCTTCTTAATCATCCTGATCATTATGT AGAAACCGAGAATATTCAGCACCTCACGGACCCTACATTAGCACATGTGGATAGAATAAGTGAAACACGGAAACTGAGTATGGGATCTGA TGATGCTGCCTACACACAAGCTCTTTTGGTACACCAGAAGGCCAGAATGGAACGACTTCAAAGAGAACTTGAGATTCAAAAGAAAAAGCT GGATAAATTAAAATCTGAGGTTAATGAAATGGAAAATAATCTAACTCGAAGGCGCCTGAAAAGATCAAATTCTATATCCCAGATACCTTC CGAAGAAGAAATGCCAGAGGTAGAAATTGACATTGATGATCTTCTTGATGCAGACAGTGATGAAGAGAGAGCTTCAAAATTACAGGAAGC TCTTGTAGACTGCTACAAACCAACAGAGGAATTTATCAAAGAGCTGCTTTCTCGGATAAGAGGCATGAGGAAACTGAGCCCTCCGCAGAA GAAGAGTGTATGATTCTGGAACAGGGTGAAACTCTCCCAGAGACGAAGAAAGAGTCCTGGGATTTGTACTTCATGAAGACTTTTGTGAAA GAATAGGTGTCCTTATGAACAACGTTTTTGTTTTTTTTTTTTTCTTTTTTGGTGTGAAGGTGGGGGGGTCTATTAGACATTTATTCAAGA GCGTTCTTTTTTTGGTTTTAAAGGTTTTTGTTAATGTAATATTTTAATAGCAAAGATATCATGACTCTAGCCACAGCCTAACCAAGGATT ATCAAAGGAGGTGGACACTCAAGGAAGGGCCACGCCAGGCTGCGTTTCCTGCAAGGACTCAGATGTTCAGTACCTTATGATACAGGGAAG ATAGTTTTCTTACAAGTAGTTTGGTAATATTTTTTTTCTTAAGTTGTACATTTGACTCAGCTGTCAAATTTCTCACACTTGTATATATCT ACACACAACTAAGTTAAAATGTTGATGTGAGTTTTATTTCACATGGATGGAATAAACTTGTGGTTGTCCTTTAACTGGAGGTCCCAGCAC ATGTGTTTTCAAGAGGCCACTAGGCATTCTTCACTGAGTGCTGCTGACTTCAACGTTCACTTTATGCACCAAAGTGAAAGAATTCAGTGT ATCCGTTATTTTAATGCACTACACCACAGAAATGTTAAGTTGGTCAAGGGCTTAATTTATGGAATTTCTATTATTTCATTGGTTGGGATG CTTTGCCAGGTCATGTGCTTATTGTCTCATTTTGTAGTCTTTTAAAGTTGTATGAACCCTTAATTTGAAGAACTAACTTGATTTCTAGAG AAATATCCACACTATCTCAGTGGTATTTTGCATTGGAAAAAGGAAGCACTGTGTAGCAGTGAATTGTCTGCTTTCCACCGAGTACTGTGT TTATTCTCTCTCCAGGAAAGCAGATCAAAAGAAAGTTAGCAGATCGAGTGTCTTCTTCCTTAGAAATAGGTTCTGGTAGCTTCTGTGCCT GGGTAGTATCAGACCAGTGGGAGTAAACCGAGTGTTAAGTGTCAAGGTGAGAAAGCCTCACATTCTCTCAAGACAGTTGCTCTAGGAGCT GAGTTGCTGGTTTGGAAGTGTGGAGATTGCATTTCTGGCTTCTCTCAATGGCTTGTGTTGAGGACTCTGGGTGCTCCTGGCCCTAATTGT GCACCCTGATCCCCGTGCTTGGAGCTAGGCCTGGTGGCGTGCTCTAGCCCTCTCAGTTACCAGCTCTTTGGAGAAGGATCAAAATTCAGA TGGAATGTGGGATGGGTAATAGGTGAGAGTAGAAACCCTTCCCTCCAGGAGGCCCCCGCTGACTCCCACAGAAACCCACCTACCATAAGA TGTCTTCAGGTGGCCTTGTCCAAGGATGGGGGTCAGGCATTTTATATCAAGGGTGCTCTGAACATATTTTATTTTTTAAAAAAACTATGT TTGTGAATTTTGCGTATACTGGCAAGCTTTTGAAAATGTATTTAATTTTGTATTGTTTACCAATGATTTATTTACAAGATATTTACTCAA >88633_88633_2_TAB2-PPP1R14C_TAB2_chr6_149718900_ENST00000367456_PPP1R14C_chr6_150535880_ENST00000361131_length(amino acids)=651AA_BP=586 MAQGSHQIDFQVLHDLRQKFPEVPEVVVSRCMLQNNNNLDACCAVLSQESTRYLYGEGDLNFSDDSGISGLRNHMTSLNLDLQSQNIYHH GREGSRMNGSRTLTHSISDGQLQGGQSNSELFQQEPQTAPAQVPQGFNVFGMSSSSGASNSAPHLGFHLGSKGTSSLSQQTPRFNPIMVT LAPNIQTGRNTPTSLHIHGVPPPVLNSPQGNSIYIRPYITTPGGTTRQTQQHSGWVSQFNPMNPQQVYQPSQPGPWTTCPASNPLSHTSS QQPNQQGHQTSHVYMPISSPTTSQPPTIHSSGSSQSSAHSQYNIQNISTGPRKNQIEIKLEPPQRNNSSKLRSSGPRTSSTSSSVNSQTL NRNQPTVYIAASPPNTDELMSRSQPKVYISANAATGDEQVMRNQPTLFISTNSGASAASRNMSGQVSMGPAFIHHHPPKSRAIGNNSATS PRVVVTQPNTKYTFKITVSPNKPPAVSPGVVSPTFELTNLLNHPDHYVETENIQHLTDPTLAHVDRISETRKLSMGSDDAAYTQALLVHQ KARMERLQRELEIQKKKLDKLKSEVNEMENNLTRRRLKRSNSISQIPSEEEMPEVEIDIDDLLDADSDEERASKLQEALVDCYKPTEEFI -------------------------------------------------------------- >88633_88633_3_TAB2-PPP1R14C_TAB2_chr6_149718900_ENST00000536230_PPP1R14C_chr6_150535880_ENST00000361131_length(transcript)=3527nt_BP=1798nt AGTGAGGTGAACTCCTTCAGGGCCACAGGCTGTAAAGATCTAAACACCATCTGATCCAGTTTCAATATGACTGCCTGGATGAAGAAGGAT TTGAGACTAAGTTTATTCCTCCAAAGCAAACCAACTGAGAATGCAGAATAATAATAACCTGGATGCCTGCTGTGCTGTTCTCTCTCAGGA GAGTACAAGATATCTTTATGGTGAAGGAGACTTGAATTTTTCAGATGATTCTGGAATTTCTGGTCTACGCAATCACATGACTTCTCTCAA CTTGGACTTGCAATCACAGAACATTTACCACCATGGAAGAGAAGGAAGTAGGATGAATGGAAGTAGGACTCTAACGCACAGCATTAGTGA TGGACAACTTCAAGGTGGCCAGTCCAATAGTGAACTATTTCAGCAGGAGCCACAGACAGCACCAGCTCAAGTTCCTCAAGGCTTTAATGT TTTTGGAATGTCCAGTTCCTCTGGTGCTTCAAATTCAGCACCACATCTTGGATTTCACTTAGGCAGCAAAGGAACATCTAGCCTTTCTCA ACAAACTCCCAGATTTAATCCCATTATGGTAACTTTAGCCCCAAATATCCAGACTGGTCGTAATACTCCTACATCTTTGCACATACATGG TGTACCTCCACCTGTACTTAACAGTCCACAGGGAAATTCTATCTATATTAGGCCTTACATTACAACTCCTGGTGGTACAACTCGACAGAC ACAACAGCATTCTGGCTGGGTATCTCAGTTTAATCCCATGAACCCTCAGCAAGTTTATCAGCCTTCACAGCCTGGTCCCTGGACTACTTG TCCTGCATCTAATCCTCTGTCACATACCTCATCTCAACAGCCAAATCAGCAAGGCCACCAGACCTCTCATGTCTACATGCCAATCAGTTC ACCTACTACTTCACAACCACCAACCATTCATTCATCTGGTAGCTCACAGTCTTCTGCCCATAGCCAATATAACATTCAGAATATTTCAAC AGGACCTCGAAAAAACCAGATTGAAATCAAACTTGAACCCCCACAAAGAAATAATTCTTCAAAACTGCGTTCTTCTGGACCTCGAACCTC CAGCACTTCCTCTTCAGTCAATAGCCAGACCTTAAACAGAAATCAGCCCACTGTTTACATAGCTGCCAGCCCCCCAAATACGGATGAGCT GATGTCCCGTAGTCAACCTAAGGTCTATATTTCAGCGAATGCTGCCACAGGAGATGAACAGGTCATGCGGAATCAGCCCACACTCTTCAT ATCCACAAACTCTGGAGCATCTGCTGCCTCCAGGAACATGTCTGGGCAAGTGAGCATGGGTCCTGCCTTTATTCATCACCATCCTCCCAA AAGTCGAGCAATAGGCAATAACTCTGCAACCTCTCCTCGAGTGGTAGTCACTCAGCCCAATACGAAATACACTTTCAAAATTACAGTCTC TCCCAATAAGCCCCCTGCAGTTTCACCAGGGGTGGTGTCCCCTACCTTTGAACTTACAAATCTTCTTAATCATCCTGATCATTATGTAGA AACCGAGAATATTCAGCACCTCACGGACCCTACATTAGCACATGTGGATAGAATAAGTGAAACACGGAAACTGAGTATGGGATCTGATGA TGCTGCCTACACACAAGCTCTTTTGGTACACCAGAAGGCCAGAATGGAACGACTTCAAAGAGAACTTGAGATTCAAAAGAAAAAGCTGGA TAAATTAAAATCTGAGGTTAATGAAATGGAAAATAATCTAACTCGAAGGCGCCTGAAAAGATCAAATTCTATATCCCAGATACCTTCCGA AGAAGAAATGCCAGAGGTAGAAATTGACATTGATGATCTTCTTGATGCAGACAGTGATGAAGAGAGAGCTTCAAAATTACAGGAAGCTCT TGTAGACTGCTACAAACCAACAGAGGAATTTATCAAAGAGCTGCTTTCTCGGATAAGAGGCATGAGGAAACTGAGCCCTCCGCAGAAGAA GAGTGTATGATTCTGGAACAGGGTGAAACTCTCCCAGAGACGAAGAAAGAGTCCTGGGATTTGTACTTCATGAAGACTTTTGTGAAAGAA TAGGTGTCCTTATGAACAACGTTTTTGTTTTTTTTTTTTTCTTTTTTGGTGTGAAGGTGGGGGGGTCTATTAGACATTTATTCAAGAGCG TTCTTTTTTTGGTTTTAAAGGTTTTTGTTAATGTAATATTTTAATAGCAAAGATATCATGACTCTAGCCACAGCCTAACCAAGGATTATC AAAGGAGGTGGACACTCAAGGAAGGGCCACGCCAGGCTGCGTTTCCTGCAAGGACTCAGATGTTCAGTACCTTATGATACAGGGAAGATA GTTTTCTTACAAGTAGTTTGGTAATATTTTTTTTCTTAAGTTGTACATTTGACTCAGCTGTCAAATTTCTCACACTTGTATATATCTACA CACAACTAAGTTAAAATGTTGATGTGAGTTTTATTTCACATGGATGGAATAAACTTGTGGTTGTCCTTTAACTGGAGGTCCCAGCACATG TGTTTTCAAGAGGCCACTAGGCATTCTTCACTGAGTGCTGCTGACTTCAACGTTCACTTTATGCACCAAAGTGAAAGAATTCAGTGTATC CGTTATTTTAATGCACTACACCACAGAAATGTTAAGTTGGTCAAGGGCTTAATTTATGGAATTTCTATTATTTCATTGGTTGGGATGCTT TGCCAGGTCATGTGCTTATTGTCTCATTTTGTAGTCTTTTAAAGTTGTATGAACCCTTAATTTGAAGAACTAACTTGATTTCTAGAGAAA TATCCACACTATCTCAGTGGTATTTTGCATTGGAAAAAGGAAGCACTGTGTAGCAGTGAATTGTCTGCTTTCCACCGAGTACTGTGTTTA TTCTCTCTCCAGGAAAGCAGATCAAAAGAAAGTTAGCAGATCGAGTGTCTTCTTCCTTAGAAATAGGTTCTGGTAGCTTCTGTGCCTGGG TAGTATCAGACCAGTGGGAGTAAACCGAGTGTTAAGTGTCAAGGTGAGAAAGCCTCACATTCTCTCAAGACAGTTGCTCTAGGAGCTGAG TTGCTGGTTTGGAAGTGTGGAGATTGCATTTCTGGCTTCTCTCAATGGCTTGTGTTGAGGACTCTGGGTGCTCCTGGCCCTAATTGTGCA CCCTGATCCCCGTGCTTGGAGCTAGGCCTGGTGGCGTGCTCTAGCCCTCTCAGTTACCAGCTCTTTGGAGAAGGATCAAAATTCAGATGG AATGTGGGATGGGTAATAGGTGAGAGTAGAAACCCTTCCCTCCAGGAGGCCCCCGCTGACTCCCACAGAAACCCACCTACCATAAGATGT CTTCAGGTGGCCTTGTCCAAGGATGGGGGTCAGGCATTTTATATCAAGGGTGCTCTGAACATATTTTATTTTTTAAAAAAACTATGTTTG TGAATTTTGCGTATACTGGCAAGCTTTTGAAAATGTATTTAATTTTGTATTGTTTACCAATGATTTATTTACAAGATATTTACTCAAATA >88633_88633_3_TAB2-PPP1R14C_TAB2_chr6_149718900_ENST00000536230_PPP1R14C_chr6_150535880_ENST00000361131_length(amino acids)=621AA_BP=556 MRMQNNNNLDACCAVLSQESTRYLYGEGDLNFSDDSGISGLRNHMTSLNLDLQSQNIYHHGREGSRMNGSRTLTHSISDGQLQGGQSNSE LFQQEPQTAPAQVPQGFNVFGMSSSSGASNSAPHLGFHLGSKGTSSLSQQTPRFNPIMVTLAPNIQTGRNTPTSLHIHGVPPPVLNSPQG NSIYIRPYITTPGGTTRQTQQHSGWVSQFNPMNPQQVYQPSQPGPWTTCPASNPLSHTSSQQPNQQGHQTSHVYMPISSPTTSQPPTIHS SGSSQSSAHSQYNIQNISTGPRKNQIEIKLEPPQRNNSSKLRSSGPRTSSTSSSVNSQTLNRNQPTVYIAASPPNTDELMSRSQPKVYIS ANAATGDEQVMRNQPTLFISTNSGASAASRNMSGQVSMGPAFIHHHPPKSRAIGNNSATSPRVVVTQPNTKYTFKITVSPNKPPAVSPGV VSPTFELTNLLNHPDHYVETENIQHLTDPTLAHVDRISETRKLSMGSDDAAYTQALLVHQKARMERLQRELEIQKKKLDKLKSEVNEMEN -------------------------------------------------------------- >88633_88633_4_TAB2-PPP1R14C_TAB2_chr6_149718900_ENST00000538427_PPP1R14C_chr6_150535880_ENST00000361131_length(transcript)=3899nt_BP=2170nt ATCGAGCGCCTAGGAGAGCCCCGGGTGGGGGAGGGCGCAAGGGGCTCGGGAGGGCCCCTCCCTGCGTCGGCGCCCCTGACCCGCCCCCAG GCATGTGTGAGGTGGGGGCGGGGGAGGAAAAATCTCCTTTTGGCTCTAGTTTACTCTAGTTTCTCTTCTGCTTTCAAGGCTCCAGACCCA GTTCCTGGACCTGCCCTGGAAAAGAAGTATCCCGTAGAGATGAGCTCACTGCAGTTACTTAATTAACAATTTGTAAGCTGCAAAAATGGC AATGGGCCAACCAAGAACAGCTACAATTTGAATTTTTCTATTTCCAGAAAATGCTTGGACAGAAGAGATGAGTACTATTTCCACTAAGGC CTAGAATTGCCTACTGTACAAATAGTCCTGATCAGGCAATATACGAATGGCCCAAGGAAGCCACCAAATTGATTTTCAGGTTTTACATGA CCTGCGACAAAAATTCCCTGAAGTACCTGAAGTTGTTGTATCCAGGTGCATGTTACAGAATAATAATAACCTGGATGCCTGCTGTGCTGT TCTCTCTCAGGAGAGTACAAGATATCTTTATGGTGAAGGAGACTTGAATTTTTCAGATGATTCTGGAATTTCTGGTCTACGCAATCACAT GACTTCTCTCAACTTGGACTTGCAATCACAGAACATTTACCACCATGGAAGAGAAGGAAGTAGGATGAATGGAAGTAGGACTCTAACGCA CAGCATTAGTGATGGACAACTTCAAGGTGGCCAGTCCAATAGTGAACTATTTCAGCAGGAGCCACAGACAGCACCAGCTCAAGTTCCTCA AGGCTTTAATGTTTTTGGAATGTCCAGTTCCTCTGGTGCTTCAAATTCAGCACCACATCTTGGATTTCACTTAGGCAGCAAAGGAACATC TAGCCTTTCTCAACAAACTCCCAGATTTAATCCCATTATGGTAACTTTAGCCCCAAATATCCAGACTGGTCGTAATACTCCTACATCTTT GCACATACATGGTGTACCTCCACCTGTACTTAACAGTCCACAGGGAAATTCTATCTATATTAGGCCTTACATTACAACTCCTGGTGGTAC AACTCGACAGACACAACAGCATTCTGGCTGGGTATCTCAGTTTAATCCCATGAACCCTCAGCAAGTTTATCAGCCTTCACAGCCTGGTCC CTGGACTACTTGTCCTGCATCTAATCCTCTGTCACATACCTCATCTCAACAGCCAAATCAGCAAGGCCACCAGACCTCTCATGTCTACAT GCCAATCAGTTCACCTACTACTTCACAACCACCAACCATTCATTCATCTGGTAGCTCACAGTCTTCTGCCCATAGCCAATATAACATTCA GAATATTTCAACAGGACCTCGAAAAAACCAGATTGAAATCAAACTTGAACCCCCACAAAGAAATAATTCTTCAAAACTGCGTTCTTCTGG ACCTCGAACCTCCAGCACTTCCTCTTCAGTCAATAGCCAGACCTTAAACAGAAATCAGCCCACTGTTTACATAGCTGCCAGCCCCCCAAA TACGGATGAGCTGATGTCCCGTAGTCAACCTAAGGTCTATATTTCAGCGAATGCTGCCACAGGAGATGAACAGGTCATGCGGAATCAGCC CACACTCTTCATATCCACAAACTCTGGAGCATCTGCTGCCTCCAGGAACATGTCTGGGCAAGTGAGCATGGGTCCTGCCTTTATTCATCA CCATCCTCCCAAAAGTCGAGCAATAGGCAATAACTCTGCAACCTCTCCTCGAGTGGTAGTCACTCAGCCCAATACGAAATACACTTTCAA AATTACAGTCTCTCCCAATAAGCCCCCTGCAGTTTCACCAGGGGTGGTGTCCCCTACCTTTGAACTTACAAATCTTCTTAATCATCCTGA TCATTATGTAGAAACCGAGAATATTCAGCACCTCACGGACCCTACATTAGCACATGTGGATAGAATAAGTGAAACACGGAAACTGAGTAT GGGATCTGATGATGCTGCCTACACACAAGCTCTTTTGGTACACCAGAAGGCCAGAATGGAACGACTTCAAAGAGAACTTGAGATTCAAAA GAAAAAGCTGGATAAATTAAAATCTGAGGTTAATGAAATGGAAAATAATCTAACTCGAAGGCGCCTGAAAAGATCAAATTCTATATCCCA GATACCTTCCGAAGAAGAAATGCCAGAGGTAGAAATTGACATTGATGATCTTCTTGATGCAGACAGTGATGAAGAGAGAGCTTCAAAATT ACAGGAAGCTCTTGTAGACTGCTACAAACCAACAGAGGAATTTATCAAAGAGCTGCTTTCTCGGATAAGAGGCATGAGGAAACTGAGCCC TCCGCAGAAGAAGAGTGTATGATTCTGGAACAGGGTGAAACTCTCCCAGAGACGAAGAAAGAGTCCTGGGATTTGTACTTCATGAAGACT TTTGTGAAAGAATAGGTGTCCTTATGAACAACGTTTTTGTTTTTTTTTTTTTCTTTTTTGGTGTGAAGGTGGGGGGGTCTATTAGACATT TATTCAAGAGCGTTCTTTTTTTGGTTTTAAAGGTTTTTGTTAATGTAATATTTTAATAGCAAAGATATCATGACTCTAGCCACAGCCTAA CCAAGGATTATCAAAGGAGGTGGACACTCAAGGAAGGGCCACGCCAGGCTGCGTTTCCTGCAAGGACTCAGATGTTCAGTACCTTATGAT ACAGGGAAGATAGTTTTCTTACAAGTAGTTTGGTAATATTTTTTTTCTTAAGTTGTACATTTGACTCAGCTGTCAAATTTCTCACACTTG TATATATCTACACACAACTAAGTTAAAATGTTGATGTGAGTTTTATTTCACATGGATGGAATAAACTTGTGGTTGTCCTTTAACTGGAGG TCCCAGCACATGTGTTTTCAAGAGGCCACTAGGCATTCTTCACTGAGTGCTGCTGACTTCAACGTTCACTTTATGCACCAAAGTGAAAGA ATTCAGTGTATCCGTTATTTTAATGCACTACACCACAGAAATGTTAAGTTGGTCAAGGGCTTAATTTATGGAATTTCTATTATTTCATTG GTTGGGATGCTTTGCCAGGTCATGTGCTTATTGTCTCATTTTGTAGTCTTTTAAAGTTGTATGAACCCTTAATTTGAAGAACTAACTTGA TTTCTAGAGAAATATCCACACTATCTCAGTGGTATTTTGCATTGGAAAAAGGAAGCACTGTGTAGCAGTGAATTGTCTGCTTTCCACCGA GTACTGTGTTTATTCTCTCTCCAGGAAAGCAGATCAAAAGAAAGTTAGCAGATCGAGTGTCTTCTTCCTTAGAAATAGGTTCTGGTAGCT TCTGTGCCTGGGTAGTATCAGACCAGTGGGAGTAAACCGAGTGTTAAGTGTCAAGGTGAGAAAGCCTCACATTCTCTCAAGACAGTTGCT CTAGGAGCTGAGTTGCTGGTTTGGAAGTGTGGAGATTGCATTTCTGGCTTCTCTCAATGGCTTGTGTTGAGGACTCTGGGTGCTCCTGGC CCTAATTGTGCACCCTGATCCCCGTGCTTGGAGCTAGGCCTGGTGGCGTGCTCTAGCCCTCTCAGTTACCAGCTCTTTGGAGAAGGATCA AAATTCAGATGGAATGTGGGATGGGTAATAGGTGAGAGTAGAAACCCTTCCCTCCAGGAGGCCCCCGCTGACTCCCACAGAAACCCACCT ACCATAAGATGTCTTCAGGTGGCCTTGTCCAAGGATGGGGGTCAGGCATTTTATATCAAGGGTGCTCTGAACATATTTTATTTTTTAAAA AAACTATGTTTGTGAATTTTGCGTATACTGGCAAGCTTTTGAAAATGTATTTAATTTTGTATTGTTTACCAATGATTTATTTACAAGATA >88633_88633_4_TAB2-PPP1R14C_TAB2_chr6_149718900_ENST00000538427_PPP1R14C_chr6_150535880_ENST00000361131_length(amino acids)=651AA_BP=586 MAQGSHQIDFQVLHDLRQKFPEVPEVVVSRCMLQNNNNLDACCAVLSQESTRYLYGEGDLNFSDDSGISGLRNHMTSLNLDLQSQNIYHH GREGSRMNGSRTLTHSISDGQLQGGQSNSELFQQEPQTAPAQVPQGFNVFGMSSSSGASNSAPHLGFHLGSKGTSSLSQQTPRFNPIMVT LAPNIQTGRNTPTSLHIHGVPPPVLNSPQGNSIYIRPYITTPGGTTRQTQQHSGWVSQFNPMNPQQVYQPSQPGPWTTCPASNPLSHTSS QQPNQQGHQTSHVYMPISSPTTSQPPTIHSSGSSQSSAHSQYNIQNISTGPRKNQIEIKLEPPQRNNSSKLRSSGPRTSSTSSSVNSQTL NRNQPTVYIAASPPNTDELMSRSQPKVYISANAATGDEQVMRNQPTLFISTNSGASAASRNMSGQVSMGPAFIHHHPPKSRAIGNNSATS PRVVVTQPNTKYTFKITVSPNKPPAVSPGVVSPTFELTNLLNHPDHYVETENIQHLTDPTLAHVDRISETRKLSMGSDDAAYTQALLVHQ KARMERLQRELEIQKKKLDKLKSEVNEMENNLTRRRLKRSNSISQIPSEEEMPEVEIDIDDLLDADSDEERASKLQEALVDCYKPTEEFI -------------------------------------------------------------- |
Top |
Fusion Gene PPI Analysis for TAB2-PPP1R14C |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| Hgene | TAB2 | chr6:149718900 | chr6:150535880 | ENST00000286332 | + | 3 | 6 | 675_685 | 588.0 | 694.0 | polyubiquitin |
| Hgene | TAB2 | chr6:149718900 | chr6:150535880 | ENST00000367456 | + | 5 | 8 | 675_685 | 588.0 | 694.0 | polyubiquitin |
| Hgene | TAB2 | chr6:149718900 | chr6:150535880 | ENST00000392282 | + | 1 | 4 | 675_685 | 0 | 537.0 | polyubiquitin |
| Hgene | TAB2 | chr6:149718900 | chr6:150535880 | ENST00000538427 | + | 5 | 8 | 675_685 | 588.0 | 694.0 | polyubiquitin |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
Related Drugs for TAB2-PPP1R14C |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
Related Diseases for TAB2-PPP1R14C |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | TAB2 | C3554279 | CONGENITAL HEART DEFECTS, MULTIPLE TYPES, 2 | 2 | CTD_human;GENOMICS_ENGLAND;UNIPROT |
| Hgene | TAB2 | C3150215 | CHROMOSOME 6q24-q25 DELETION SYNDROME | 1 | GENOMICS_ENGLAND |
| Hgene | TAB2 | C4509918 | Polyvalvular heart disease syndrome | 1 | ORPHANET |
Copyright 2021-Present -The University of Texas Health Science Center at Houston (UTHealth)
Web File Viewing | Emergency Information |Campus Carry|Site Policies