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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ANKLE2-SNU13 (FusionGDB2 ID:HG23141TG4809)

Fusion Gene Summary for ANKLE2-SNU13

check button Fusion gene summary
Fusion gene informationFusion gene name: ANKLE2-SNU13
Fusion gene ID: hg23141tg4809
HgeneTgene
Gene symbol

ANKLE2

SNU13

Gene ID

23141

4809

Gene nameankyrin repeat and LEM domain containing 2small nuclear ribonucleoprotein 13
SynonymsKIAA0692|LEMD7|Lem4|MCPH1615.5K|FA-1|FA1|NHP2L1|NHPX|OTK27|SNRNP15-5|SPAG12|SSFA1
Cytomap('ANKLE2','ANKLE2')('NHP2L1','SNU13')

12q24.33

22q13.2

Type of geneprotein-codingprotein-coding
Descriptionankyrin repeat and LEM domain-containing protein 2LEM domain containing 7LEM domain-containing protein 4NHP2-like protein 1NHP2 non-histone chromosome protein 2-like 1SNU13 homolog, small nuclear ribonucleoprotein (U4/U6.U5)U4/U6.U5 tri-snRNP 15.5 kDa protein[U4/U6.U5] tri-snRNP 15.5 kD RNA binding proteinhigh mobility group-like nuclear protein 2 homo
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000337516, ENST00000357997, 
ENST00000539605, ENST00000542282, 
ENST00000542374, ENST00000542657, 
Fusion gene scores* DoF score8 X 7 X 7=3925 X 3 X 5=75
# samples 96
** MAII scorelog2(9/392*10)=-2.12285674778553
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(6/75*10)=-0.321928094887362
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ANKLE2 [Title/Abstract] AND SNU13 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointANKLE2(133324418)-NHP2L1(42076368), # samples:2
ANKLE2(133324418)-SNU13(42076368), # samples:1
Anticipated loss of major functional domain due to fusion event.ANKLE2-NHP2L1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ANKLE2-NHP2L1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ANKLE2-NHP2L1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ANKLE2-NHP2L1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneANKLE2

GO:0007417

central nervous system development

25259927

HgeneANKLE2

GO:0035307

positive regulation of protein dephosphorylation

22770216

HgeneANKLE2

GO:0042326

negative regulation of phosphorylation

22770216

HgeneANKLE2

GO:0043066

negative regulation of apoptotic process

25259927

TgeneSNU13

GO:0000398

mRNA splicing, via spliceosome

28781166


check buttonFusion gene breakpoints across ANKLE2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across SNU13 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-BH-A0B7-01AANKLE2chr12

133324418

-NHP2L1chr22

42076368

-
ChimerDB4BRCATCGA-BH-A0B7-01AANKLE2chr12

133324418

-SNU13chr22

42076368

-
ChimerDB4BRCATCGA-BH-A0B7ANKLE2chr12

133324417

-NHP2L1chr22

42076368

-


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Fusion Gene ORF analysis for ANKLE2-SNU13

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000337516ENST00000402458ANKLE2chr12

133324418

-NHP2L1chr22

42076368

-
5CDS-5UTRENST00000337516ENST00000402458ANKLE2chr12

133324417

-NHP2L1chr22

42076368

-
5CDS-5UTRENST00000337516ENST00000463675ANKLE2chr12

133324418

-NHP2L1chr22

42076368

-
5CDS-5UTRENST00000337516ENST00000463675ANKLE2chr12

133324417

-NHP2L1chr22

42076368

-
5CDS-5UTRENST00000357997ENST00000402458ANKLE2chr12

133324418

-NHP2L1chr22

42076368

-
5CDS-5UTRENST00000357997ENST00000402458ANKLE2chr12

133324417

-NHP2L1chr22

42076368

-
5CDS-5UTRENST00000357997ENST00000463675ANKLE2chr12

133324418

-NHP2L1chr22

42076368

-
5CDS-5UTRENST00000357997ENST00000463675ANKLE2chr12

133324417

-NHP2L1chr22

42076368

-
5CDS-5UTRENST00000539605ENST00000402458ANKLE2chr12

133324418

-NHP2L1chr22

42076368

-
5CDS-5UTRENST00000539605ENST00000402458ANKLE2chr12

133324417

-NHP2L1chr22

42076368

-
5CDS-5UTRENST00000539605ENST00000463675ANKLE2chr12

133324418

-NHP2L1chr22

42076368

-
5CDS-5UTRENST00000539605ENST00000463675ANKLE2chr12

133324417

-NHP2L1chr22

42076368

-
In-frameENST00000337516ENST00000215956ANKLE2chr12

133324418

-NHP2L1chr22

42076368

-
In-frameENST00000337516ENST00000215956ANKLE2chr12

133324417

-NHP2L1chr22

42076368

-
In-frameENST00000337516ENST00000355257ANKLE2chr12

133324418

-NHP2L1chr22

42076368

-
In-frameENST00000337516ENST00000355257ANKLE2chr12

133324417

-NHP2L1chr22

42076368

-
In-frameENST00000337516ENST00000401959ANKLE2chr12

133324418

-NHP2L1chr22

42076368

-
In-frameENST00000337516ENST00000401959ANKLE2chr12

133324417

-NHP2L1chr22

42076368

-
In-frameENST00000357997ENST00000215956ANKLE2chr12

133324418

-NHP2L1chr22

42076368

-
In-frameENST00000357997ENST00000215956ANKLE2chr12

133324417

-NHP2L1chr22

42076368

-
In-frameENST00000357997ENST00000355257ANKLE2chr12

133324418

-NHP2L1chr22

42076368

-
In-frameENST00000357997ENST00000355257ANKLE2chr12

133324417

-NHP2L1chr22

42076368

-
In-frameENST00000357997ENST00000401959ANKLE2chr12

133324418

-NHP2L1chr22

42076368

-
In-frameENST00000357997ENST00000401959ANKLE2chr12

133324417

-NHP2L1chr22

42076368

-
In-frameENST00000539605ENST00000215956ANKLE2chr12

133324418

-NHP2L1chr22

42076368

-
In-frameENST00000539605ENST00000215956ANKLE2chr12

133324417

-NHP2L1chr22

42076368

-
In-frameENST00000539605ENST00000355257ANKLE2chr12

133324418

-NHP2L1chr22

42076368

-
In-frameENST00000539605ENST00000355257ANKLE2chr12

133324417

-NHP2L1chr22

42076368

-
In-frameENST00000539605ENST00000401959ANKLE2chr12

133324418

-NHP2L1chr22

42076368

-
In-frameENST00000539605ENST00000401959ANKLE2chr12

133324417

-NHP2L1chr22

42076368

-
intron-3CDSENST00000542282ENST00000215956ANKLE2chr12

133324418

-NHP2L1chr22

42076368

-
intron-3CDSENST00000542282ENST00000215956ANKLE2chr12

133324417

-NHP2L1chr22

42076368

-
intron-3CDSENST00000542282ENST00000355257ANKLE2chr12

133324418

-NHP2L1chr22

42076368

-
intron-3CDSENST00000542282ENST00000355257ANKLE2chr12

133324417

-NHP2L1chr22

42076368

-
intron-3CDSENST00000542282ENST00000401959ANKLE2chr12

133324418

-NHP2L1chr22

42076368

-
intron-3CDSENST00000542282ENST00000401959ANKLE2chr12

133324417

-NHP2L1chr22

42076368

-
intron-3CDSENST00000542374ENST00000215956ANKLE2chr12

133324418

-NHP2L1chr22

42076368

-
intron-3CDSENST00000542374ENST00000215956ANKLE2chr12

133324417

-NHP2L1chr22

42076368

-
intron-3CDSENST00000542374ENST00000355257ANKLE2chr12

133324418

-NHP2L1chr22

42076368

-
intron-3CDSENST00000542374ENST00000355257ANKLE2chr12

133324417

-NHP2L1chr22

42076368

-
intron-3CDSENST00000542374ENST00000401959ANKLE2chr12

133324418

-NHP2L1chr22

42076368

-
intron-3CDSENST00000542374ENST00000401959ANKLE2chr12

133324417

-NHP2L1chr22

42076368

-
intron-3CDSENST00000542657ENST00000215956ANKLE2chr12

133324418

-NHP2L1chr22

42076368

-
intron-3CDSENST00000542657ENST00000215956ANKLE2chr12

133324417

-NHP2L1chr22

42076368

-
intron-3CDSENST00000542657ENST00000355257ANKLE2chr12

133324418

-NHP2L1chr22

42076368

-
intron-3CDSENST00000542657ENST00000355257ANKLE2chr12

133324417

-NHP2L1chr22

42076368

-
intron-3CDSENST00000542657ENST00000401959ANKLE2chr12

133324418

-NHP2L1chr22

42076368

-
intron-3CDSENST00000542657ENST00000401959ANKLE2chr12

133324417

-NHP2L1chr22

42076368

-
intron-5UTRENST00000542282ENST00000402458ANKLE2chr12

133324418

-NHP2L1chr22

42076368

-
intron-5UTRENST00000542282ENST00000402458ANKLE2chr12

133324417

-NHP2L1chr22

42076368

-
intron-5UTRENST00000542282ENST00000463675ANKLE2chr12

133324418

-NHP2L1chr22

42076368

-
intron-5UTRENST00000542282ENST00000463675ANKLE2chr12

133324417

-NHP2L1chr22

42076368

-
intron-5UTRENST00000542374ENST00000402458ANKLE2chr12

133324418

-NHP2L1chr22

42076368

-
intron-5UTRENST00000542374ENST00000402458ANKLE2chr12

133324417

-NHP2L1chr22

42076368

-
intron-5UTRENST00000542374ENST00000463675ANKLE2chr12

133324418

-NHP2L1chr22

42076368

-
intron-5UTRENST00000542374ENST00000463675ANKLE2chr12

133324417

-NHP2L1chr22

42076368

-
intron-5UTRENST00000542657ENST00000402458ANKLE2chr12

133324418

-NHP2L1chr22

42076368

-
intron-5UTRENST00000542657ENST00000402458ANKLE2chr12

133324417

-NHP2L1chr22

42076368

-
intron-5UTRENST00000542657ENST00000463675ANKLE2chr12

133324418

-NHP2L1chr22

42076368

-
intron-5UTRENST00000542657ENST00000463675ANKLE2chr12

133324417

-NHP2L1chr22

42076368

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000539605ANKLE2chr12133324417-ENST00000355257NHP2L1chr2242076368-9116772966708112480
ENST00000539605ANKLE2chr12133324417-ENST00000215956NHP2L1chr2242076368-9092772966708112480
ENST00000539605ANKLE2chr12133324417-ENST00000401959NHP2L1chr2242076368-9079772966708112480
ENST00000357997ANKLE2chr12133324417-ENST00000355257NHP2L1chr2242076368-27071320901703537
ENST00000357997ANKLE2chr12133324417-ENST00000215956NHP2L1chr2242076368-26831320901703537
ENST00000357997ANKLE2chr12133324417-ENST00000401959NHP2L1chr2242076368-26701320901703537
ENST00000337516ANKLE2chr12133324417-ENST00000355257NHP2L1chr2242076368-26841297671680537
ENST00000337516ANKLE2chr12133324417-ENST00000215956NHP2L1chr2242076368-26601297671680537
ENST00000337516ANKLE2chr12133324417-ENST00000401959NHP2L1chr2242076368-26471297671680537
ENST00000539605ANKLE2chr12133324418-ENST00000355257NHP2L1chr2242076368-9116772966708112480
ENST00000539605ANKLE2chr12133324418-ENST00000215956NHP2L1chr2242076368-9092772966708112480
ENST00000539605ANKLE2chr12133324418-ENST00000401959NHP2L1chr2242076368-9079772966708112480
ENST00000357997ANKLE2chr12133324418-ENST00000355257NHP2L1chr2242076368-27071320901703537
ENST00000357997ANKLE2chr12133324418-ENST00000215956NHP2L1chr2242076368-26831320901703537
ENST00000357997ANKLE2chr12133324418-ENST00000401959NHP2L1chr2242076368-26701320901703537
ENST00000337516ANKLE2chr12133324418-ENST00000355257NHP2L1chr2242076368-26841297671680537
ENST00000337516ANKLE2chr12133324418-ENST00000215956NHP2L1chr2242076368-26601297671680537
ENST00000337516ANKLE2chr12133324418-ENST00000401959NHP2L1chr2242076368-26471297671680537

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000539605ENST00000355257ANKLE2chr12133324417-NHP2L1chr2242076368-0.0026950720.9973049
ENST00000539605ENST00000215956ANKLE2chr12133324417-NHP2L1chr2242076368-0.002589070.99741095
ENST00000539605ENST00000401959ANKLE2chr12133324417-NHP2L1chr2242076368-0.0028701320.99712986
ENST00000357997ENST00000355257ANKLE2chr12133324417-NHP2L1chr2242076368-0.0017975180.99820244
ENST00000357997ENST00000215956ANKLE2chr12133324417-NHP2L1chr2242076368-0.0019139650.9980861
ENST00000357997ENST00000401959ANKLE2chr12133324417-NHP2L1chr2242076368-0.0018807570.9981192
ENST00000337516ENST00000355257ANKLE2chr12133324417-NHP2L1chr2242076368-0.0017496820.9982503
ENST00000337516ENST00000215956ANKLE2chr12133324417-NHP2L1chr2242076368-0.0018631660.99813676
ENST00000337516ENST00000401959ANKLE2chr12133324417-NHP2L1chr2242076368-0.0018285830.99817145
ENST00000539605ENST00000355257ANKLE2chr12133324418-NHP2L1chr2242076368-0.0026950720.9973049
ENST00000539605ENST00000215956ANKLE2chr12133324418-NHP2L1chr2242076368-0.002589070.99741095
ENST00000539605ENST00000401959ANKLE2chr12133324418-NHP2L1chr2242076368-0.0028701320.99712986
ENST00000357997ENST00000355257ANKLE2chr12133324418-NHP2L1chr2242076368-0.0017975180.99820244
ENST00000357997ENST00000215956ANKLE2chr12133324418-NHP2L1chr2242076368-0.0019139650.9980861
ENST00000357997ENST00000401959ANKLE2chr12133324418-NHP2L1chr2242076368-0.0018807570.9981192
ENST00000337516ENST00000355257ANKLE2chr12133324418-NHP2L1chr2242076368-0.0017496820.9982503
ENST00000337516ENST00000215956ANKLE2chr12133324418-NHP2L1chr2242076368-0.0018631660.99813676
ENST00000337516ENST00000401959ANKLE2chr12133324418-NHP2L1chr2242076368-0.0018285830.99817145

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Fusion Genomic Features for ANKLE2-SNU13


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for ANKLE2-SNU13


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:133324418/:42076368)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneANKLE2chr12:133324417chr22:42076368ENST00000337516-51169_113410649.0DomainLEM
HgeneANKLE2chr12:133324417chr22:42076368ENST00000357997-51369_113410939.0DomainLEM
HgeneANKLE2chr12:133324418chr22:42076368ENST00000337516-51169_113410649.0DomainLEM
HgeneANKLE2chr12:133324418chr22:42076368ENST00000357997-51369_113410939.0DomainLEM
HgeneANKLE2chr12:133324417chr22:42076368ENST00000337516-5111_12410649.0Topological domainLumenal
HgeneANKLE2chr12:133324417chr22:42076368ENST00000357997-5131_12410939.0Topological domainLumenal
HgeneANKLE2chr12:133324418chr22:42076368ENST00000337516-5111_12410649.0Topological domainLumenal
HgeneANKLE2chr12:133324418chr22:42076368ENST00000357997-5131_12410939.0Topological domainLumenal
HgeneANKLE2chr12:133324417chr22:42076368ENST00000337516-51113_32410649.0TransmembraneHelical%3B Signal-anchor for type III membrane protein
HgeneANKLE2chr12:133324417chr22:42076368ENST00000357997-51313_32410939.0TransmembraneHelical%3B Signal-anchor for type III membrane protein
HgeneANKLE2chr12:133324418chr22:42076368ENST00000337516-51113_32410649.0TransmembraneHelical%3B Signal-anchor for type III membrane protein
HgeneANKLE2chr12:133324418chr22:42076368ENST00000357997-51313_32410939.0TransmembraneHelical%3B Signal-anchor for type III membrane protein

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneANKLE2chr12:133324417chr22:42076368ENST00000542282-1369_1130294.0DomainLEM
HgeneANKLE2chr12:133324417chr22:42076368ENST00000542657-1469_1130294.0DomainLEM
HgeneANKLE2chr12:133324418chr22:42076368ENST00000542282-1369_1130294.0DomainLEM
HgeneANKLE2chr12:133324418chr22:42076368ENST00000542657-1469_1130294.0DomainLEM
HgeneANKLE2chr12:133324417chr22:42076368ENST00000337516-511411_440410649.0RepeatNote=ANK
HgeneANKLE2chr12:133324417chr22:42076368ENST00000357997-513411_440410939.0RepeatNote=ANK
HgeneANKLE2chr12:133324417chr22:42076368ENST00000542282-13411_4400294.0RepeatNote=ANK
HgeneANKLE2chr12:133324417chr22:42076368ENST00000542657-14411_4400294.0RepeatNote=ANK
HgeneANKLE2chr12:133324418chr22:42076368ENST00000337516-511411_440410649.0RepeatNote=ANK
HgeneANKLE2chr12:133324418chr22:42076368ENST00000357997-513411_440410939.0RepeatNote=ANK
HgeneANKLE2chr12:133324418chr22:42076368ENST00000542282-13411_4400294.0RepeatNote=ANK
HgeneANKLE2chr12:133324418chr22:42076368ENST00000542657-14411_4400294.0RepeatNote=ANK
HgeneANKLE2chr12:133324417chr22:42076368ENST00000337516-51133_938410649.0Topological domainCytoplasmic
HgeneANKLE2chr12:133324417chr22:42076368ENST00000357997-51333_938410939.0Topological domainCytoplasmic
HgeneANKLE2chr12:133324417chr22:42076368ENST00000542282-131_120294.0Topological domainLumenal
HgeneANKLE2chr12:133324417chr22:42076368ENST00000542282-1333_9380294.0Topological domainCytoplasmic
HgeneANKLE2chr12:133324417chr22:42076368ENST00000542657-141_120294.0Topological domainLumenal
HgeneANKLE2chr12:133324417chr22:42076368ENST00000542657-1433_9380294.0Topological domainCytoplasmic
HgeneANKLE2chr12:133324418chr22:42076368ENST00000337516-51133_938410649.0Topological domainCytoplasmic
HgeneANKLE2chr12:133324418chr22:42076368ENST00000357997-51333_938410939.0Topological domainCytoplasmic
HgeneANKLE2chr12:133324418chr22:42076368ENST00000542282-131_120294.0Topological domainLumenal
HgeneANKLE2chr12:133324418chr22:42076368ENST00000542282-1333_9380294.0Topological domainCytoplasmic
HgeneANKLE2chr12:133324418chr22:42076368ENST00000542657-141_120294.0Topological domainLumenal
HgeneANKLE2chr12:133324418chr22:42076368ENST00000542657-1433_9380294.0Topological domainCytoplasmic
HgeneANKLE2chr12:133324417chr22:42076368ENST00000542282-1313_320294.0TransmembraneHelical%3B Signal-anchor for type III membrane protein
HgeneANKLE2chr12:133324417chr22:42076368ENST00000542657-1413_320294.0TransmembraneHelical%3B Signal-anchor for type III membrane protein
HgeneANKLE2chr12:133324418chr22:42076368ENST00000542282-1313_320294.0TransmembraneHelical%3B Signal-anchor for type III membrane protein
HgeneANKLE2chr12:133324418chr22:42076368ENST00000542657-1413_320294.0TransmembraneHelical%3B Signal-anchor for type III membrane protein


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Fusion Gene Sequence for ANKLE2-SNU13


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>4500_4500_1_ANKLE2-NHP2L1_ANKLE2_chr12_133324417_ENST00000337516_NHP2L1_chr22_42076368_ENST00000215956_length(transcript)=2660nt_BP=1297nt
GCGGGGTCCTGGGACGGGCGCGGCGCGGGGCGCGGGCTTCTCGGCGGCTGCGGCCCGGGCGGCGGCGATGCTGTGGCCGCGGCTGGCGGC
GGCCGAGTGGGCGGCGCTGGCCTGGGAGCTGCTGGGCGCCTCGGTGCTGCTGATCGCTGTGCGGTGGCTGGTGCGGCGGCTGGGCCCGCG
GCCGGGAGGTCTGGGCCGCAGCGGGACCCCAGTTCCTCCGCCAAGCGCGGCCGCCGCCCCCGCCTCAGGTGAAATGACAATGGATGCTCT
GTTGGCTCGATTGAAACTTCTGAATCCAGATGACCTTAGAGAAGAAATCGTCAAAGCCGGATTGAAATGTGGACCCATTACATCAACTAC
AAGGTTCATTTTTGAGAAAAAATTGGCTCAGGCTTTACTGGAGCAAGGAGGAAGGCTGTCTTCTTTCTACCACCATGAGGCAGGTGTCAC
AGCTCTCAGCCAGGACCCACAAAGGATTTTGAAGCCAGCTGAAGGGAACCCAACTGATCAGGCTGGTTTTTCTGAAGACAGAGATTTTGG
TTACAGTGTGGGCCTGAATCCTCCAGAGGAGGAAGCTGTGACATCCAAGACCTGCTCGGTGCCCCCTAGTGACACCGACACCTACAGAGC
TGGAGCGACTGCGTCTAAGGAGCCGCCCCTGTACTATGGGGTGTGTCCAGTGTATGAGGACGTCCCAGCGAGAAATGAAAGGATCTATGT
TTATGAAAATAAAAAGGAAGCATTGCAAGCTGTCAAGATGATCAAAGGGTCCCGATTTAAAGCTTTTTCTACCAGAGAAGACGCTGAGAA
ATTTGCTAGAGGAATTTGTGATTATTTCCCTTCTCCAAGCAAAACGTCCTTACCACTGTCTCCTGTGAAAACAGCTCCACTCTTTAGCAA
TGACAGGTTGAAAGATGGTTTGTGCTTGTCGGAATCAGAAACAGTCAACAAAGAGCGAGCGAACAGTTACAAAAATCCCCGCACGCAGGA
CCTCACCGCCAAGCTTCGGAAAGCTGTGGAGAAGGGAGAGGAGGACACCTTTTCTGACCTTATCTGGAGCAACCCCCGGTATCTGATAGG
CTCAGGAGACAACCCCACTATCGTGCAGGAAGGGTGCAGGTACAACGTGATGCATGTTGCTGCCAAAGAGAACCAGGCTTCCATCTGCCA
GCTGACTCTGGACGTCCTGGAGAACCCTGACTTCATGAGGCTGATGTACCCTGATGACGACGAGGCCATGCTGCAGAAGCGTATCCGTTA
CGTGGTGGACCTGTACCTCAACACCCCCGACAAGATGACTGAGGCTGATGTGAATCCAAAGGCCTATCCCCTTGCCGATGCCCACCTCAC
CAAGAAGCTACTGGACCTCGTTCAGCAGTCATGTAACTATAAGCAGCTTCGGAAAGGAGCCAATGAGGCCACCAAAACCCTCAACAGGGG
CATCTCTGAGTTCATCGTGATGGCTGCAGACGCCGAGCCACTGGAGATCATTCTGCACCTGCCGCTGCTGTGTGAAGACAAGAATGTGCC
CTACGTGTTTGTGCGCTCCAAGCAGGCCCTGGGGAGAGCCTGTGGGGTCTCCAGGCCTGTCATCGCCTGTTCTGTCACCATCAAAGAAGG
CTCGCAGCTGAAACAGCAGATCCAATCCATTCAGCAGTCCATTGAAAGGCTCTTAGTCTAAACCTGTGGCCTCTGCCACGTGCTCCCTGC
CAGCTTCCCCCCTGAGGTTGTGTATCATATTATCTGTGTTAGCATGTAGTATTTTCAGCTACTCTCTATTGTTATAAAATGTAGTACTAA
ATCTGGTTTCTGGATTTTTGTGTTGTTTTTGTTCTGTTTTACAGGGTTGCTATCCCCCTTCCTTTCCTCCCTCCCTCTGCCATCCTTCAT
CCTTTTATCCTCCCTTTTTGGAACAAGTGTTCAGAGCAGACAGAAGCAGGGTGGTGGCACCGTTGAAAGGCAGAAAGAGCCAGGAGAAAG
CTGATGGAGCCAGGACAGAGATCTGGTTCCAGCTTTCAGCCACTAGCTTCCTGTTGTGTGCGGGGTGTGGTGGAATTAAACAGCATTCAT
TGTGTGTCCCTGTGCCTGGCACACAGAATCATTCATACGTGTTCAAGTGATCAAGGGGTTTCATTTGCTCTTGGGGGATTAGGTATCATT
TGGGGAGGAAGCATGTGTTCTGTGAGGTTGTTCGGCTATGTCCAAGTGTCGTTTACTAATGTACCCCTGCTGTTTGCTTTTGGTAATGTG
ATGTTGATGTTCTCCCCCTACCCACAACCATGCCCTTGAGGGTAGCAGGGCAGCAGCATACCAAAGAGATGTGCTGCAGGACTCCGGAGG
CAGCCTGGGTGGGTGAGCCATGGGGCAGTTGACCTGGGTCTTGAAAGAGTCGGGAGTGACAAGCTCAGAGAGCATGAACTGATGCTGGCA
TGAAGGATTCCAGGAAGATCATGGAGACCTGGCTGGTAGCTGTAACAGAGATGGTGGAGTCCAAGGAAACAGCCTGTCTCTGGTGAATGG
GACTTTCTTTGGTGGACACTTGGCACCAGCTCTGAGAGCCCTTCCCCTGTGTCCTGCCACCATGTGGGTCAGATGTACTCTCTGTCACAT

>4500_4500_1_ANKLE2-NHP2L1_ANKLE2_chr12_133324417_ENST00000337516_NHP2L1_chr22_42076368_ENST00000215956_length(amino acids)=537AA_BP=410
MLWPRLAAAEWAALAWELLGASVLLIAVRWLVRRLGPRPGGLGRSGTPVPPPSAAAAPASGEMTMDALLARLKLLNPDDLREEIVKAGLK
CGPITSTTRFIFEKKLAQALLEQGGRLSSFYHHEAGVTALSQDPQRILKPAEGNPTDQAGFSEDRDFGYSVGLNPPEEEAVTSKTCSVPP
SDTDTYRAGATASKEPPLYYGVCPVYEDVPARNERIYVYENKKEALQAVKMIKGSRFKAFSTREDAEKFARGICDYFPSPSKTSLPLSPV
KTAPLFSNDRLKDGLCLSESETVNKERANSYKNPRTQDLTAKLRKAVEKGEEDTFSDLIWSNPRYLIGSGDNPTIVQEGCRYNVMHVAAK
ENQASICQLTLDVLENPDFMRLMYPDDDEAMLQKRIRYVVDLYLNTPDKMTEADVNPKAYPLADAHLTKKLLDLVQQSCNYKQLRKGANE

--------------------------------------------------------------
>4500_4500_2_ANKLE2-NHP2L1_ANKLE2_chr12_133324417_ENST00000337516_NHP2L1_chr22_42076368_ENST00000355257_length(transcript)=2684nt_BP=1297nt
GCGGGGTCCTGGGACGGGCGCGGCGCGGGGCGCGGGCTTCTCGGCGGCTGCGGCCCGGGCGGCGGCGATGCTGTGGCCGCGGCTGGCGGC
GGCCGAGTGGGCGGCGCTGGCCTGGGAGCTGCTGGGCGCCTCGGTGCTGCTGATCGCTGTGCGGTGGCTGGTGCGGCGGCTGGGCCCGCG
GCCGGGAGGTCTGGGCCGCAGCGGGACCCCAGTTCCTCCGCCAAGCGCGGCCGCCGCCCCCGCCTCAGGTGAAATGACAATGGATGCTCT
GTTGGCTCGATTGAAACTTCTGAATCCAGATGACCTTAGAGAAGAAATCGTCAAAGCCGGATTGAAATGTGGACCCATTACATCAACTAC
AAGGTTCATTTTTGAGAAAAAATTGGCTCAGGCTTTACTGGAGCAAGGAGGAAGGCTGTCTTCTTTCTACCACCATGAGGCAGGTGTCAC
AGCTCTCAGCCAGGACCCACAAAGGATTTTGAAGCCAGCTGAAGGGAACCCAACTGATCAGGCTGGTTTTTCTGAAGACAGAGATTTTGG
TTACAGTGTGGGCCTGAATCCTCCAGAGGAGGAAGCTGTGACATCCAAGACCTGCTCGGTGCCCCCTAGTGACACCGACACCTACAGAGC
TGGAGCGACTGCGTCTAAGGAGCCGCCCCTGTACTATGGGGTGTGTCCAGTGTATGAGGACGTCCCAGCGAGAAATGAAAGGATCTATGT
TTATGAAAATAAAAAGGAAGCATTGCAAGCTGTCAAGATGATCAAAGGGTCCCGATTTAAAGCTTTTTCTACCAGAGAAGACGCTGAGAA
ATTTGCTAGAGGAATTTGTGATTATTTCCCTTCTCCAAGCAAAACGTCCTTACCACTGTCTCCTGTGAAAACAGCTCCACTCTTTAGCAA
TGACAGGTTGAAAGATGGTTTGTGCTTGTCGGAATCAGAAACAGTCAACAAAGAGCGAGCGAACAGTTACAAAAATCCCCGCACGCAGGA
CCTCACCGCCAAGCTTCGGAAAGCTGTGGAGAAGGGAGAGGAGGACACCTTTTCTGACCTTATCTGGAGCAACCCCCGGTATCTGATAGG
CTCAGGAGACAACCCCACTATCGTGCAGGAAGGGTGCAGGTACAACGTGATGCATGTTGCTGCCAAAGAGAACCAGGCTTCCATCTGCCA
GCTGACTCTGGACGTCCTGGAGAACCCTGACTTCATGAGGCTGATGTACCCTGATGACGACGAGGCCATGCTGCAGAAGCGTATCCGTTA
CGTGGTGGACCTGTACCTCAACACCCCCGACAAGATGACTGAGGCTGATGTGAATCCAAAGGCCTATCCCCTTGCCGATGCCCACCTCAC
CAAGAAGCTACTGGACCTCGTTCAGCAGTCATGTAACTATAAGCAGCTTCGGAAAGGAGCCAATGAGGCCACCAAAACCCTCAACAGGGG
CATCTCTGAGTTCATCGTGATGGCTGCAGACGCCGAGCCACTGGAGATCATTCTGCACCTGCCGCTGCTGTGTGAAGACAAGAATGTGCC
CTACGTGTTTGTGCGCTCCAAGCAGGCCCTGGGGAGAGCCTGTGGGGTCTCCAGGCCTGTCATCGCCTGTTCTGTCACCATCAAAGAAGG
CTCGCAGCTGAAACAGCAGATCCAATCCATTCAGCAGTCCATTGAAAGGCTCTTAGTCTAAACCTGTGGCCTCTGCCACGTGCTCCCTGC
CAGCTTCCCCCCTGAGGTTGTGTATCATATTATCTGTGTTAGCATGTAGTATTTTCAGCTACTCTCTATTGTTATAAAATGTAGTACTAA
ATCTGGTTTCTGGATTTTTGTGTTGTTTTTGTTCTGTTTTACAGGGTTGCTATCCCCCTTCCTTTCCTCCCTCCCTCTGCCATCCTTCAT
CCTTTTATCCTCCCTTTTTGGAACAAGTGTTCAGAGCAGACAGAAGCAGGGTGGTGGCACCGTTGAAAGGCAGAAAGAGCCAGGAGAAAG
CTGATGGAGCCAGGACAGAGATCTGGTTCCAGCTTTCAGCCACTAGCTTCCTGTTGTGTGCGGGGTGTGGTGGAATTAAACAGCATTCAT
TGTGTGTCCCTGTGCCTGGCACACAGAATCATTCATACGTGTTCAAGTGATCAAGGGGTTTCATTTGCTCTTGGGGGATTAGGTATCATT
TGGGGAGGAAGCATGTGTTCTGTGAGGTTGTTCGGCTATGTCCAAGTGTCGTTTACTAATGTACCCCTGCTGTTTGCTTTTGGTAATGTG
ATGTTGATGTTCTCCCCCTACCCACAACCATGCCCTTGAGGGTAGCAGGGCAGCAGCATACCAAAGAGATGTGCTGCAGGACTCCGGAGG
CAGCCTGGGTGGGTGAGCCATGGGGCAGTTGACCTGGGTCTTGAAAGAGTCGGGAGTGACAAGCTCAGAGAGCATGAACTGATGCTGGCA
TGAAGGATTCCAGGAAGATCATGGAGACCTGGCTGGTAGCTGTAACAGAGATGGTGGAGTCCAAGGAAACAGCCTGTCTCTGGTGAATGG
GACTTTCTTTGGTGGACACTTGGCACCAGCTCTGAGAGCCCTTCCCCTGTGTCCTGCCACCATGTGGGTCAGATGTACTCTCTGTCACAT

>4500_4500_2_ANKLE2-NHP2L1_ANKLE2_chr12_133324417_ENST00000337516_NHP2L1_chr22_42076368_ENST00000355257_length(amino acids)=537AA_BP=410
MLWPRLAAAEWAALAWELLGASVLLIAVRWLVRRLGPRPGGLGRSGTPVPPPSAAAAPASGEMTMDALLARLKLLNPDDLREEIVKAGLK
CGPITSTTRFIFEKKLAQALLEQGGRLSSFYHHEAGVTALSQDPQRILKPAEGNPTDQAGFSEDRDFGYSVGLNPPEEEAVTSKTCSVPP
SDTDTYRAGATASKEPPLYYGVCPVYEDVPARNERIYVYENKKEALQAVKMIKGSRFKAFSTREDAEKFARGICDYFPSPSKTSLPLSPV
KTAPLFSNDRLKDGLCLSESETVNKERANSYKNPRTQDLTAKLRKAVEKGEEDTFSDLIWSNPRYLIGSGDNPTIVQEGCRYNVMHVAAK
ENQASICQLTLDVLENPDFMRLMYPDDDEAMLQKRIRYVVDLYLNTPDKMTEADVNPKAYPLADAHLTKKLLDLVQQSCNYKQLRKGANE

--------------------------------------------------------------
>4500_4500_3_ANKLE2-NHP2L1_ANKLE2_chr12_133324417_ENST00000337516_NHP2L1_chr22_42076368_ENST00000401959_length(transcript)=2647nt_BP=1297nt
GCGGGGTCCTGGGACGGGCGCGGCGCGGGGCGCGGGCTTCTCGGCGGCTGCGGCCCGGGCGGCGGCGATGCTGTGGCCGCGGCTGGCGGC
GGCCGAGTGGGCGGCGCTGGCCTGGGAGCTGCTGGGCGCCTCGGTGCTGCTGATCGCTGTGCGGTGGCTGGTGCGGCGGCTGGGCCCGCG
GCCGGGAGGTCTGGGCCGCAGCGGGACCCCAGTTCCTCCGCCAAGCGCGGCCGCCGCCCCCGCCTCAGGTGAAATGACAATGGATGCTCT
GTTGGCTCGATTGAAACTTCTGAATCCAGATGACCTTAGAGAAGAAATCGTCAAAGCCGGATTGAAATGTGGACCCATTACATCAACTAC
AAGGTTCATTTTTGAGAAAAAATTGGCTCAGGCTTTACTGGAGCAAGGAGGAAGGCTGTCTTCTTTCTACCACCATGAGGCAGGTGTCAC
AGCTCTCAGCCAGGACCCACAAAGGATTTTGAAGCCAGCTGAAGGGAACCCAACTGATCAGGCTGGTTTTTCTGAAGACAGAGATTTTGG
TTACAGTGTGGGCCTGAATCCTCCAGAGGAGGAAGCTGTGACATCCAAGACCTGCTCGGTGCCCCCTAGTGACACCGACACCTACAGAGC
TGGAGCGACTGCGTCTAAGGAGCCGCCCCTGTACTATGGGGTGTGTCCAGTGTATGAGGACGTCCCAGCGAGAAATGAAAGGATCTATGT
TTATGAAAATAAAAAGGAAGCATTGCAAGCTGTCAAGATGATCAAAGGGTCCCGATTTAAAGCTTTTTCTACCAGAGAAGACGCTGAGAA
ATTTGCTAGAGGAATTTGTGATTATTTCCCTTCTCCAAGCAAAACGTCCTTACCACTGTCTCCTGTGAAAACAGCTCCACTCTTTAGCAA
TGACAGGTTGAAAGATGGTTTGTGCTTGTCGGAATCAGAAACAGTCAACAAAGAGCGAGCGAACAGTTACAAAAATCCCCGCACGCAGGA
CCTCACCGCCAAGCTTCGGAAAGCTGTGGAGAAGGGAGAGGAGGACACCTTTTCTGACCTTATCTGGAGCAACCCCCGGTATCTGATAGG
CTCAGGAGACAACCCCACTATCGTGCAGGAAGGGTGCAGGTACAACGTGATGCATGTTGCTGCCAAAGAGAACCAGGCTTCCATCTGCCA
GCTGACTCTGGACGTCCTGGAGAACCCTGACTTCATGAGGCTGATGTACCCTGATGACGACGAGGCCATGCTGCAGAAGCGTATCCGTTA
CGTGGTGGACCTGTACCTCAACACCCCCGACAAGATGACTGAGGCTGATGTGAATCCAAAGGCCTATCCCCTTGCCGATGCCCACCTCAC
CAAGAAGCTACTGGACCTCGTTCAGCAGTCATGTAACTATAAGCAGCTTCGGAAAGGAGCCAATGAGGCCACCAAAACCCTCAACAGGGG
CATCTCTGAGTTCATCGTGATGGCTGCAGACGCCGAGCCACTGGAGATCATTCTGCACCTGCCGCTGCTGTGTGAAGACAAGAATGTGCC
CTACGTGTTTGTGCGCTCCAAGCAGGCCCTGGGGAGAGCCTGTGGGGTCTCCAGGCCTGTCATCGCCTGTTCTGTCACCATCAAAGAAGG
CTCGCAGCTGAAACAGCAGATCCAATCCATTCAGCAGTCCATTGAAAGGCTCTTAGTCTAAACCTGTGGCCTCTGCCACGTGCTCCCTGC
CAGCTTCCCCCCTGAGGTTGTGTATCATATTATCTGTGTTAGCATGTAGTATTTTCAGCTACTCTCTATTGTTATAAAATGTAGTACTAA
ATCTGGTTTCTGGATTTTTGTGTTGTTTTTGTTCTGTTTTACAGGGTTGCTATCCCCCTTCCTTTCCTCCCTCCCTCTGCCATCCTTCAT
CCTTTTATCCTCCCTTTTTGGAACAAGTGTTCAGAGCAGACAGAAGCAGGGTGGTGGCACCGTTGAAAGGCAGAAAGAGCCAGGAGAAAG
CTGATGGAGCCAGGACAGAGATCTGGTTCCAGCTTTCAGCCACTAGCTTCCTGTTGTGTGCGGGGTGTGGTGGAATTAAACAGCATTCAT
TGTGTGTCCCTGTGCCTGGCACACAGAATCATTCATACGTGTTCAAGTGATCAAGGGGTTTCATTTGCTCTTGGGGGATTAGGTATCATT
TGGGGAGGAAGCATGTGTTCTGTGAGGTTGTTCGGCTATGTCCAAGTGTCGTTTACTAATGTACCCCTGCTGTTTGCTTTTGGTAATGTG
ATGTTGATGTTCTCCCCCTACCCACAACCATGCCCTTGAGGGTAGCAGGGCAGCAGCATACCAAAGAGATGTGCTGCAGGACTCCGGAGG
CAGCCTGGGTGGGTGAGCCATGGGGCAGTTGACCTGGGTCTTGAAAGAGTCGGGAGTGACAAGCTCAGAGAGCATGAACTGATGCTGGCA
TGAAGGATTCCAGGAAGATCATGGAGACCTGGCTGGTAGCTGTAACAGAGATGGTGGAGTCCAAGGAAACAGCCTGTCTCTGGTGAATGG
GACTTTCTTTGGTGGACACTTGGCACCAGCTCTGAGAGCCCTTCCCCTGTGTCCTGCCACCATGTGGGTCAGATGTACTCTCTGTCACAT

>4500_4500_3_ANKLE2-NHP2L1_ANKLE2_chr12_133324417_ENST00000337516_NHP2L1_chr22_42076368_ENST00000401959_length(amino acids)=537AA_BP=410
MLWPRLAAAEWAALAWELLGASVLLIAVRWLVRRLGPRPGGLGRSGTPVPPPSAAAAPASGEMTMDALLARLKLLNPDDLREEIVKAGLK
CGPITSTTRFIFEKKLAQALLEQGGRLSSFYHHEAGVTALSQDPQRILKPAEGNPTDQAGFSEDRDFGYSVGLNPPEEEAVTSKTCSVPP
SDTDTYRAGATASKEPPLYYGVCPVYEDVPARNERIYVYENKKEALQAVKMIKGSRFKAFSTREDAEKFARGICDYFPSPSKTSLPLSPV
KTAPLFSNDRLKDGLCLSESETVNKERANSYKNPRTQDLTAKLRKAVEKGEEDTFSDLIWSNPRYLIGSGDNPTIVQEGCRYNVMHVAAK
ENQASICQLTLDVLENPDFMRLMYPDDDEAMLQKRIRYVVDLYLNTPDKMTEADVNPKAYPLADAHLTKKLLDLVQQSCNYKQLRKGANE

--------------------------------------------------------------
>4500_4500_4_ANKLE2-NHP2L1_ANKLE2_chr12_133324417_ENST00000357997_NHP2L1_chr22_42076368_ENST00000215956_length(transcript)=2683nt_BP=1320nt
AGGCAGGGCGCGGGCAGCCCGGCGCGGGGTCCTGGGACGGGCGCGGCGCGGGGCGCGGGCTTCTCGGCGGCTGCGGCCCGGGCGGCGGCG
ATGCTGTGGCCGCGGCTGGCGGCGGCCGAGTGGGCGGCGCTGGCCTGGGAGCTGCTGGGCGCCTCGGTGCTGCTGATCGCTGTGCGGTGG
CTGGTGCGGCGGCTGGGCCCGCGGCCGGGAGGTCTGGGCCGCAGCGGGACCCCAGTTCCTCCGCCAAGCGCGGCCGCCGCCCCCGCCTCA
GGTGAAATGACAATGGATGCTCTGTTGGCTCGATTGAAACTTCTGAATCCAGATGACCTTAGAGAAGAAATCGTCAAAGCCGGATTGAAA
TGTGGACCCATTACATCAACTACAAGGTTCATTTTTGAGAAAAAATTGGCTCAGGCTTTACTGGAGCAAGGAGGAAGGCTGTCTTCTTTC
TACCACCATGAGGCAGGTGTCACAGCTCTCAGCCAGGACCCACAAAGGATTTTGAAGCCAGCTGAAGGGAACCCAACTGATCAGGCTGGT
TTTTCTGAAGACAGAGATTTTGGTTACAGTGTGGGCCTGAATCCTCCAGAGGAGGAAGCTGTGACATCCAAGACCTGCTCGGTGCCCCCT
AGTGACACCGACACCTACAGAGCTGGAGCGACTGCGTCTAAGGAGCCGCCCCTGTACTATGGGGTGTGTCCAGTGTATGAGGACGTCCCA
GCGAGAAATGAAAGGATCTATGTTTATGAAAATAAAAAGGAAGCATTGCAAGCTGTCAAGATGATCAAAGGGTCCCGATTTAAAGCTTTT
TCTACCAGAGAAGACGCTGAGAAATTTGCTAGAGGAATTTGTGATTATTTCCCTTCTCCAAGCAAAACGTCCTTACCACTGTCTCCTGTG
AAAACAGCTCCACTCTTTAGCAATGACAGGTTGAAAGATGGTTTGTGCTTGTCGGAATCAGAAACAGTCAACAAAGAGCGAGCGAACAGT
TACAAAAATCCCCGCACGCAGGACCTCACCGCCAAGCTTCGGAAAGCTGTGGAGAAGGGAGAGGAGGACACCTTTTCTGACCTTATCTGG
AGCAACCCCCGGTATCTGATAGGCTCAGGAGACAACCCCACTATCGTGCAGGAAGGGTGCAGGTACAACGTGATGCATGTTGCTGCCAAA
GAGAACCAGGCTTCCATCTGCCAGCTGACTCTGGACGTCCTGGAGAACCCTGACTTCATGAGGCTGATGTACCCTGATGACGACGAGGCC
ATGCTGCAGAAGCGTATCCGTTACGTGGTGGACCTGTACCTCAACACCCCCGACAAGATGACTGAGGCTGATGTGAATCCAAAGGCCTAT
CCCCTTGCCGATGCCCACCTCACCAAGAAGCTACTGGACCTCGTTCAGCAGTCATGTAACTATAAGCAGCTTCGGAAAGGAGCCAATGAG
GCCACCAAAACCCTCAACAGGGGCATCTCTGAGTTCATCGTGATGGCTGCAGACGCCGAGCCACTGGAGATCATTCTGCACCTGCCGCTG
CTGTGTGAAGACAAGAATGTGCCCTACGTGTTTGTGCGCTCCAAGCAGGCCCTGGGGAGAGCCTGTGGGGTCTCCAGGCCTGTCATCGCC
TGTTCTGTCACCATCAAAGAAGGCTCGCAGCTGAAACAGCAGATCCAATCCATTCAGCAGTCCATTGAAAGGCTCTTAGTCTAAACCTGT
GGCCTCTGCCACGTGCTCCCTGCCAGCTTCCCCCCTGAGGTTGTGTATCATATTATCTGTGTTAGCATGTAGTATTTTCAGCTACTCTCT
ATTGTTATAAAATGTAGTACTAAATCTGGTTTCTGGATTTTTGTGTTGTTTTTGTTCTGTTTTACAGGGTTGCTATCCCCCTTCCTTTCC
TCCCTCCCTCTGCCATCCTTCATCCTTTTATCCTCCCTTTTTGGAACAAGTGTTCAGAGCAGACAGAAGCAGGGTGGTGGCACCGTTGAA
AGGCAGAAAGAGCCAGGAGAAAGCTGATGGAGCCAGGACAGAGATCTGGTTCCAGCTTTCAGCCACTAGCTTCCTGTTGTGTGCGGGGTG
TGGTGGAATTAAACAGCATTCATTGTGTGTCCCTGTGCCTGGCACACAGAATCATTCATACGTGTTCAAGTGATCAAGGGGTTTCATTTG
CTCTTGGGGGATTAGGTATCATTTGGGGAGGAAGCATGTGTTCTGTGAGGTTGTTCGGCTATGTCCAAGTGTCGTTTACTAATGTACCCC
TGCTGTTTGCTTTTGGTAATGTGATGTTGATGTTCTCCCCCTACCCACAACCATGCCCTTGAGGGTAGCAGGGCAGCAGCATACCAAAGA
GATGTGCTGCAGGACTCCGGAGGCAGCCTGGGTGGGTGAGCCATGGGGCAGTTGACCTGGGTCTTGAAAGAGTCGGGAGTGACAAGCTCA
GAGAGCATGAACTGATGCTGGCATGAAGGATTCCAGGAAGATCATGGAGACCTGGCTGGTAGCTGTAACAGAGATGGTGGAGTCCAAGGA
AACAGCCTGTCTCTGGTGAATGGGACTTTCTTTGGTGGACACTTGGCACCAGCTCTGAGAGCCCTTCCCCTGTGTCCTGCCACCATGTGG

>4500_4500_4_ANKLE2-NHP2L1_ANKLE2_chr12_133324417_ENST00000357997_NHP2L1_chr22_42076368_ENST00000215956_length(amino acids)=537AA_BP=410
MLWPRLAAAEWAALAWELLGASVLLIAVRWLVRRLGPRPGGLGRSGTPVPPPSAAAAPASGEMTMDALLARLKLLNPDDLREEIVKAGLK
CGPITSTTRFIFEKKLAQALLEQGGRLSSFYHHEAGVTALSQDPQRILKPAEGNPTDQAGFSEDRDFGYSVGLNPPEEEAVTSKTCSVPP
SDTDTYRAGATASKEPPLYYGVCPVYEDVPARNERIYVYENKKEALQAVKMIKGSRFKAFSTREDAEKFARGICDYFPSPSKTSLPLSPV
KTAPLFSNDRLKDGLCLSESETVNKERANSYKNPRTQDLTAKLRKAVEKGEEDTFSDLIWSNPRYLIGSGDNPTIVQEGCRYNVMHVAAK
ENQASICQLTLDVLENPDFMRLMYPDDDEAMLQKRIRYVVDLYLNTPDKMTEADVNPKAYPLADAHLTKKLLDLVQQSCNYKQLRKGANE

--------------------------------------------------------------
>4500_4500_5_ANKLE2-NHP2L1_ANKLE2_chr12_133324417_ENST00000357997_NHP2L1_chr22_42076368_ENST00000355257_length(transcript)=2707nt_BP=1320nt
AGGCAGGGCGCGGGCAGCCCGGCGCGGGGTCCTGGGACGGGCGCGGCGCGGGGCGCGGGCTTCTCGGCGGCTGCGGCCCGGGCGGCGGCG
ATGCTGTGGCCGCGGCTGGCGGCGGCCGAGTGGGCGGCGCTGGCCTGGGAGCTGCTGGGCGCCTCGGTGCTGCTGATCGCTGTGCGGTGG
CTGGTGCGGCGGCTGGGCCCGCGGCCGGGAGGTCTGGGCCGCAGCGGGACCCCAGTTCCTCCGCCAAGCGCGGCCGCCGCCCCCGCCTCA
GGTGAAATGACAATGGATGCTCTGTTGGCTCGATTGAAACTTCTGAATCCAGATGACCTTAGAGAAGAAATCGTCAAAGCCGGATTGAAA
TGTGGACCCATTACATCAACTACAAGGTTCATTTTTGAGAAAAAATTGGCTCAGGCTTTACTGGAGCAAGGAGGAAGGCTGTCTTCTTTC
TACCACCATGAGGCAGGTGTCACAGCTCTCAGCCAGGACCCACAAAGGATTTTGAAGCCAGCTGAAGGGAACCCAACTGATCAGGCTGGT
TTTTCTGAAGACAGAGATTTTGGTTACAGTGTGGGCCTGAATCCTCCAGAGGAGGAAGCTGTGACATCCAAGACCTGCTCGGTGCCCCCT
AGTGACACCGACACCTACAGAGCTGGAGCGACTGCGTCTAAGGAGCCGCCCCTGTACTATGGGGTGTGTCCAGTGTATGAGGACGTCCCA
GCGAGAAATGAAAGGATCTATGTTTATGAAAATAAAAAGGAAGCATTGCAAGCTGTCAAGATGATCAAAGGGTCCCGATTTAAAGCTTTT
TCTACCAGAGAAGACGCTGAGAAATTTGCTAGAGGAATTTGTGATTATTTCCCTTCTCCAAGCAAAACGTCCTTACCACTGTCTCCTGTG
AAAACAGCTCCACTCTTTAGCAATGACAGGTTGAAAGATGGTTTGTGCTTGTCGGAATCAGAAACAGTCAACAAAGAGCGAGCGAACAGT
TACAAAAATCCCCGCACGCAGGACCTCACCGCCAAGCTTCGGAAAGCTGTGGAGAAGGGAGAGGAGGACACCTTTTCTGACCTTATCTGG
AGCAACCCCCGGTATCTGATAGGCTCAGGAGACAACCCCACTATCGTGCAGGAAGGGTGCAGGTACAACGTGATGCATGTTGCTGCCAAA
GAGAACCAGGCTTCCATCTGCCAGCTGACTCTGGACGTCCTGGAGAACCCTGACTTCATGAGGCTGATGTACCCTGATGACGACGAGGCC
ATGCTGCAGAAGCGTATCCGTTACGTGGTGGACCTGTACCTCAACACCCCCGACAAGATGACTGAGGCTGATGTGAATCCAAAGGCCTAT
CCCCTTGCCGATGCCCACCTCACCAAGAAGCTACTGGACCTCGTTCAGCAGTCATGTAACTATAAGCAGCTTCGGAAAGGAGCCAATGAG
GCCACCAAAACCCTCAACAGGGGCATCTCTGAGTTCATCGTGATGGCTGCAGACGCCGAGCCACTGGAGATCATTCTGCACCTGCCGCTG
CTGTGTGAAGACAAGAATGTGCCCTACGTGTTTGTGCGCTCCAAGCAGGCCCTGGGGAGAGCCTGTGGGGTCTCCAGGCCTGTCATCGCC
TGTTCTGTCACCATCAAAGAAGGCTCGCAGCTGAAACAGCAGATCCAATCCATTCAGCAGTCCATTGAAAGGCTCTTAGTCTAAACCTGT
GGCCTCTGCCACGTGCTCCCTGCCAGCTTCCCCCCTGAGGTTGTGTATCATATTATCTGTGTTAGCATGTAGTATTTTCAGCTACTCTCT
ATTGTTATAAAATGTAGTACTAAATCTGGTTTCTGGATTTTTGTGTTGTTTTTGTTCTGTTTTACAGGGTTGCTATCCCCCTTCCTTTCC
TCCCTCCCTCTGCCATCCTTCATCCTTTTATCCTCCCTTTTTGGAACAAGTGTTCAGAGCAGACAGAAGCAGGGTGGTGGCACCGTTGAA
AGGCAGAAAGAGCCAGGAGAAAGCTGATGGAGCCAGGACAGAGATCTGGTTCCAGCTTTCAGCCACTAGCTTCCTGTTGTGTGCGGGGTG
TGGTGGAATTAAACAGCATTCATTGTGTGTCCCTGTGCCTGGCACACAGAATCATTCATACGTGTTCAAGTGATCAAGGGGTTTCATTTG
CTCTTGGGGGATTAGGTATCATTTGGGGAGGAAGCATGTGTTCTGTGAGGTTGTTCGGCTATGTCCAAGTGTCGTTTACTAATGTACCCC
TGCTGTTTGCTTTTGGTAATGTGATGTTGATGTTCTCCCCCTACCCACAACCATGCCCTTGAGGGTAGCAGGGCAGCAGCATACCAAAGA
GATGTGCTGCAGGACTCCGGAGGCAGCCTGGGTGGGTGAGCCATGGGGCAGTTGACCTGGGTCTTGAAAGAGTCGGGAGTGACAAGCTCA
GAGAGCATGAACTGATGCTGGCATGAAGGATTCCAGGAAGATCATGGAGACCTGGCTGGTAGCTGTAACAGAGATGGTGGAGTCCAAGGA
AACAGCCTGTCTCTGGTGAATGGGACTTTCTTTGGTGGACACTTGGCACCAGCTCTGAGAGCCCTTCCCCTGTGTCCTGCCACCATGTGG
GTCAGATGTACTCTCTGTCACATGAGGAGAGTGCTAGTTCATGTGTTCTCCATTCTTGTGAGCATCCTAATAAATCTGTTCCATTTTGAT

>4500_4500_5_ANKLE2-NHP2L1_ANKLE2_chr12_133324417_ENST00000357997_NHP2L1_chr22_42076368_ENST00000355257_length(amino acids)=537AA_BP=410
MLWPRLAAAEWAALAWELLGASVLLIAVRWLVRRLGPRPGGLGRSGTPVPPPSAAAAPASGEMTMDALLARLKLLNPDDLREEIVKAGLK
CGPITSTTRFIFEKKLAQALLEQGGRLSSFYHHEAGVTALSQDPQRILKPAEGNPTDQAGFSEDRDFGYSVGLNPPEEEAVTSKTCSVPP
SDTDTYRAGATASKEPPLYYGVCPVYEDVPARNERIYVYENKKEALQAVKMIKGSRFKAFSTREDAEKFARGICDYFPSPSKTSLPLSPV
KTAPLFSNDRLKDGLCLSESETVNKERANSYKNPRTQDLTAKLRKAVEKGEEDTFSDLIWSNPRYLIGSGDNPTIVQEGCRYNVMHVAAK
ENQASICQLTLDVLENPDFMRLMYPDDDEAMLQKRIRYVVDLYLNTPDKMTEADVNPKAYPLADAHLTKKLLDLVQQSCNYKQLRKGANE

--------------------------------------------------------------
>4500_4500_6_ANKLE2-NHP2L1_ANKLE2_chr12_133324417_ENST00000357997_NHP2L1_chr22_42076368_ENST00000401959_length(transcript)=2670nt_BP=1320nt
AGGCAGGGCGCGGGCAGCCCGGCGCGGGGTCCTGGGACGGGCGCGGCGCGGGGCGCGGGCTTCTCGGCGGCTGCGGCCCGGGCGGCGGCG
ATGCTGTGGCCGCGGCTGGCGGCGGCCGAGTGGGCGGCGCTGGCCTGGGAGCTGCTGGGCGCCTCGGTGCTGCTGATCGCTGTGCGGTGG
CTGGTGCGGCGGCTGGGCCCGCGGCCGGGAGGTCTGGGCCGCAGCGGGACCCCAGTTCCTCCGCCAAGCGCGGCCGCCGCCCCCGCCTCA
GGTGAAATGACAATGGATGCTCTGTTGGCTCGATTGAAACTTCTGAATCCAGATGACCTTAGAGAAGAAATCGTCAAAGCCGGATTGAAA
TGTGGACCCATTACATCAACTACAAGGTTCATTTTTGAGAAAAAATTGGCTCAGGCTTTACTGGAGCAAGGAGGAAGGCTGTCTTCTTTC
TACCACCATGAGGCAGGTGTCACAGCTCTCAGCCAGGACCCACAAAGGATTTTGAAGCCAGCTGAAGGGAACCCAACTGATCAGGCTGGT
TTTTCTGAAGACAGAGATTTTGGTTACAGTGTGGGCCTGAATCCTCCAGAGGAGGAAGCTGTGACATCCAAGACCTGCTCGGTGCCCCCT
AGTGACACCGACACCTACAGAGCTGGAGCGACTGCGTCTAAGGAGCCGCCCCTGTACTATGGGGTGTGTCCAGTGTATGAGGACGTCCCA
GCGAGAAATGAAAGGATCTATGTTTATGAAAATAAAAAGGAAGCATTGCAAGCTGTCAAGATGATCAAAGGGTCCCGATTTAAAGCTTTT
TCTACCAGAGAAGACGCTGAGAAATTTGCTAGAGGAATTTGTGATTATTTCCCTTCTCCAAGCAAAACGTCCTTACCACTGTCTCCTGTG
AAAACAGCTCCACTCTTTAGCAATGACAGGTTGAAAGATGGTTTGTGCTTGTCGGAATCAGAAACAGTCAACAAAGAGCGAGCGAACAGT
TACAAAAATCCCCGCACGCAGGACCTCACCGCCAAGCTTCGGAAAGCTGTGGAGAAGGGAGAGGAGGACACCTTTTCTGACCTTATCTGG
AGCAACCCCCGGTATCTGATAGGCTCAGGAGACAACCCCACTATCGTGCAGGAAGGGTGCAGGTACAACGTGATGCATGTTGCTGCCAAA
GAGAACCAGGCTTCCATCTGCCAGCTGACTCTGGACGTCCTGGAGAACCCTGACTTCATGAGGCTGATGTACCCTGATGACGACGAGGCC
ATGCTGCAGAAGCGTATCCGTTACGTGGTGGACCTGTACCTCAACACCCCCGACAAGATGACTGAGGCTGATGTGAATCCAAAGGCCTAT
CCCCTTGCCGATGCCCACCTCACCAAGAAGCTACTGGACCTCGTTCAGCAGTCATGTAACTATAAGCAGCTTCGGAAAGGAGCCAATGAG
GCCACCAAAACCCTCAACAGGGGCATCTCTGAGTTCATCGTGATGGCTGCAGACGCCGAGCCACTGGAGATCATTCTGCACCTGCCGCTG
CTGTGTGAAGACAAGAATGTGCCCTACGTGTTTGTGCGCTCCAAGCAGGCCCTGGGGAGAGCCTGTGGGGTCTCCAGGCCTGTCATCGCC
TGTTCTGTCACCATCAAAGAAGGCTCGCAGCTGAAACAGCAGATCCAATCCATTCAGCAGTCCATTGAAAGGCTCTTAGTCTAAACCTGT
GGCCTCTGCCACGTGCTCCCTGCCAGCTTCCCCCCTGAGGTTGTGTATCATATTATCTGTGTTAGCATGTAGTATTTTCAGCTACTCTCT
ATTGTTATAAAATGTAGTACTAAATCTGGTTTCTGGATTTTTGTGTTGTTTTTGTTCTGTTTTACAGGGTTGCTATCCCCCTTCCTTTCC
TCCCTCCCTCTGCCATCCTTCATCCTTTTATCCTCCCTTTTTGGAACAAGTGTTCAGAGCAGACAGAAGCAGGGTGGTGGCACCGTTGAA
AGGCAGAAAGAGCCAGGAGAAAGCTGATGGAGCCAGGACAGAGATCTGGTTCCAGCTTTCAGCCACTAGCTTCCTGTTGTGTGCGGGGTG
TGGTGGAATTAAACAGCATTCATTGTGTGTCCCTGTGCCTGGCACACAGAATCATTCATACGTGTTCAAGTGATCAAGGGGTTTCATTTG
CTCTTGGGGGATTAGGTATCATTTGGGGAGGAAGCATGTGTTCTGTGAGGTTGTTCGGCTATGTCCAAGTGTCGTTTACTAATGTACCCC
TGCTGTTTGCTTTTGGTAATGTGATGTTGATGTTCTCCCCCTACCCACAACCATGCCCTTGAGGGTAGCAGGGCAGCAGCATACCAAAGA
GATGTGCTGCAGGACTCCGGAGGCAGCCTGGGTGGGTGAGCCATGGGGCAGTTGACCTGGGTCTTGAAAGAGTCGGGAGTGACAAGCTCA
GAGAGCATGAACTGATGCTGGCATGAAGGATTCCAGGAAGATCATGGAGACCTGGCTGGTAGCTGTAACAGAGATGGTGGAGTCCAAGGA
AACAGCCTGTCTCTGGTGAATGGGACTTTCTTTGGTGGACACTTGGCACCAGCTCTGAGAGCCCTTCCCCTGTGTCCTGCCACCATGTGG

>4500_4500_6_ANKLE2-NHP2L1_ANKLE2_chr12_133324417_ENST00000357997_NHP2L1_chr22_42076368_ENST00000401959_length(amino acids)=537AA_BP=410
MLWPRLAAAEWAALAWELLGASVLLIAVRWLVRRLGPRPGGLGRSGTPVPPPSAAAAPASGEMTMDALLARLKLLNPDDLREEIVKAGLK
CGPITSTTRFIFEKKLAQALLEQGGRLSSFYHHEAGVTALSQDPQRILKPAEGNPTDQAGFSEDRDFGYSVGLNPPEEEAVTSKTCSVPP
SDTDTYRAGATASKEPPLYYGVCPVYEDVPARNERIYVYENKKEALQAVKMIKGSRFKAFSTREDAEKFARGICDYFPSPSKTSLPLSPV
KTAPLFSNDRLKDGLCLSESETVNKERANSYKNPRTQDLTAKLRKAVEKGEEDTFSDLIWSNPRYLIGSGDNPTIVQEGCRYNVMHVAAK
ENQASICQLTLDVLENPDFMRLMYPDDDEAMLQKRIRYVVDLYLNTPDKMTEADVNPKAYPLADAHLTKKLLDLVQQSCNYKQLRKGANE

--------------------------------------------------------------
>4500_4500_7_ANKLE2-NHP2L1_ANKLE2_chr12_133324417_ENST00000539605_NHP2L1_chr22_42076368_ENST00000215956_length(transcript)=9092nt_BP=7729nt
GCCCGGGCGGCGGCGATGCTGTGGCCGCGGCTGGCGGCGGCCGAGTGGGCGGCGCTGGCCTGGGAGCTGCTGGGCGCCTCGGTGCTGCTG
ATCGCTGTGCGGTGGCTGGTGCGGCGGCTGGGCCCGCGGCCGGGAGGTCTGGGCCGCAGCGGGACCCCAGTTCCTCCGCCAAGCGCGGCC
GCCGCCCCCGCCTCAGGTAAGGCCCAGGCGGTCGCTGGGTCCCCGCACCCTGGCCCCTTCCCCGCCCCGACGCCCTCCTCGGGCCTGGGG
TCCCGGCCGCGCCCCTGGAGCCGGCAGCAGTTGGGCGAGGCGGCCGGGGAAACCAGGGCCGGTCGGGAAAGGCCATTCCGGCCGCGGAAA
GGGCAGTTGCGGGGACTTGGCTTCCCGGGCCGGGGGCGGAGGGGCCACGCCGGGTTCGGGGGTGAGAGCTTTCCCGGGCCCTGGAGCAGC
CTCCGGGGAAGGCGGCGGGGGCCCGGCGAGGCGTTAGCGGAGACTCTTGCTGCGGTCTCTCGAGACCTGGGGAGGGATGGCCCAAAGGAG
GGCGGCGCGGGGAGGAAACCCCTGGGTCCCGGATGTGTTTGGAACGTGAAGCCATTGCGGTTACTGGTCATGGAACATAAGGCAGAGACG
GAAAAGGCAAATGTAACTCAGGGGTTTGGGGCCAGAGGAAGAGGGAGAAGGTGGCCATTTATTGCTTTGCGGTAGACTGTCGGGTCTGGG
TGATGTGGAGATCAGAGGTGGGTTTTGGTCGTTTTAAGTTTGAGGTAACTGATACAGTGAACTGTGTATTTCAGCTCCATCCCCTTTTCC
TGGCATACAACTCTTGAAATCCCGGGAACCTCCAAAGTGATGTCTTTTGTAGGCTGAGTGGACTGGTGGCCGGCAGCCCCTAGGGAGCTT
CTGGATGGGGCTGGTCGCAGGAAAGACCAAGGCAGGGTTAGAGGTTCTGGGGACTTTCAGCCCCACCCCCAACCTCTGGGGAGGAGAGAG
GGGTGAAGGTTGCGTTGATCACCAGTGGCTGATGAATCACGCCTGTGAAATGAAGTTCCTGTAAAAACCCAAAAGGGCTGGGTTCAGGGA
GCTTCCAGATAGTACGTGGGGGTTCCTGGAGGCGGTGCCCAGAGAGGCCCTGAATTTCCAAGCGCTTCCCCCCGGTTTTACGTCACGCAT
CTCTTCACCTGTATTCTTTGTAATCCTTTATACTCTGCTGGTAAGTGTAAGTAAAACATGTCTGTGAGTTCGGGAGCCACTCTAGCAAAT
TACCGCAACCTGAGGAGGTCACCGGGTTACGCCCCGTCGGTCCCAAGCGCAGGTCAAACAACCTGGGCACTGGAAGTGGGGGGCAGTCTT
GCGGGGCTGAGCCGTTAACCTGTGGGGGTCTGCTGGTATCTCCAGGAAGACGCTGTCAGAATAGATGACTGAATTAGGATGACAGACGAC
ACCCAGCCTGTGTCCACTGCAGAACTGACGACCTGCGTGATTTGTGGGGAGAAAATCCCCACATACCTGGTGTCCGAAGCATGTTGCAAG
ACTAGTGGGAGAAACTGAGTTTGTTTTTACTCTAAATTGTCAGACTGTTAGTCACTGCGGAGAGGTGCTTTCTGATGATTGAGTGGGGAT
TCCTGTCCAATTGTGTGAGTTTGTGTCTCGGCCCTACCACTTTTTTTTTTTTTTTTTTTTGAAATGTAGTCTCGCCCTGTGGCCCAGGCT
GGAGTGCAGTGGCGCGATCTCGGCTCACTGCAAGCTCCGCCTCCCGGGTTCAAGCGATTCTCCTGCATCAGCCTCCCGAGTAGCTGGGAT
TACAGGCGCCTGCCACCACGCCCGGCTAATTTTTGTATTTTTAATAGAGACGGGGTTTCACCATGTTGGCCAGGATGGTCTCGAATTCCT
GACCTCAGGTGATCCACCTGCCTCAGCTTCCCAAAATGCTGGGATTACAGGTGTGAGCCATCGCACCGGGCCCTACCACTTATTGCTGTG
GGCTTAACCTGTTTTCAGCCTGCTCTTTTAGGAATGGGGATGATAGTGATACCTGGTTAGGCTTTTTTGGGAGTTGGGTAAGTGCAGCAC
TTGGTATGTGTTAAGCACCTCTGAGTGCTGTTACTGTCACCAGCGGCATCATCCAGGCAGAGCTGCGGACAAGGTGGCGGCGGGTGAGGG
TGGTGTTTTGAGAATGGCTGAAATAAAAAAATACTGATTTATTTTATATAAAAATATGTTTTTATATATGATGTATAATATACGTATATC
ATGGCATATGATACGTGTATATCATATAGCACATATAGTATACATATATATAGTCAGCAGAGATTTAGAGAAACTGGGCCTCGTGCATTG
CAGGTGGGGACGGTAAGTGGTGCAGCTACTCTGGGAATCAGCCTGGCAGGTTTTTAGGAAGTTAAACCTGCCCTGCATTCCTGAGCTTTT
ATTAGACAAATGAAAACTATTTTCACACAAAAACCCATATTTAATGTTCATAGCAACTTTATTTGTAATTACCAGAAACTGAAATAACTC
AAATGGTTAAACTTGCACACTGATACCCCGGGGTGCCACTCCGCAGCGATCCTCTCTGCCACGTGGGTGCCCCGGGGTGCCACTCTGCAT
GATCCACTCTGCCACGTGGGTGCCCCGGGGTGCCACTCCGCAGCGATCCTCTCTGCCACGTGGGTGCCCCGGGGTGCCACTCTGCGTGAT
CCACTCTGCCACGTGGGTGCCCCGGGGTGCCACTCCGCAGCGATCCTCTCTGCCACGTGGGTGCCCCGGGGTGCCACTCCGCAGCGATCC
ACTCTGCCACGTGGGTGCCCCGGGGTGCCACTCCGCAGCGATCCTCTCTGCCACGTGGGTGCCCCGGGGTGCCACACTGCGTGATCCACT
CTGCCACGTGGGTGCCCCGGGGTGCCACTCCGCAGCGATCCACTCTGCCACGTGGGTGGATCTCAAGGGCATTATGCTGAATAGGAAAAG
CCAGTCTCAAAAGTTGTGTACTTGGCCGGTTGCGGTGGCTCATGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGCAGGTGGATCACAAG
GTCAGGAGTTCAAGATCAGCCTGGCCAACATGGTGAGGCAGTCTCCACTAAAAATACAAAAAAATAGCGGGGCGTGGTGGCAGGTACCTG
TAATCCCAGCTACTCGGGAGGCTGAGGCAGCAGAATTGCTTGAACCCAGGAGGTGGAGGTTGCGGTGAGCAGAGATCGTGCCACTGCACT
CCAGCCTGGGCGACAGAGCAAGACTCCATCTCAAAAAAAAAAAAATTGTTAATGGAACATTATAACCCAGTGTTCAGACCTAGCTGTTTC
TCACATCTTTACCCATCGATCTGTCAAAGACCTTGTGATCATACTGATACTTCCAATTTCAATGCGACGTCCGCGGGTTTATTCTTTTTT
TTTTAGGTGGAGTCTCACTCTGTTGTCCAGGCTGGAGACTCACTGCAACCTCTGCCTGCCCAGTTCAAGCGATTCTCCCACCTAGCCTGC
TGAGTAGCTGGGATGACAGGTGCATGCCACCATGCCTGGCTAATTTTTGTGTTTTTAGTAGACACCTGGTTTCATCATGTTGGCCAGGCT
GGTCTCAAACACCTGACCTCAAATGATCCATGCACCTTGGCCTCCCAAAGTGCTGGGATTACCAGCATGAGCCACCGTGTCCGGCTCCCT
GGCTTTATTCTAATGCAAGAGTCAGTAAACTGTGGTCCAAACTGGCCCCCACCTATTTTCCTTAGTAAAGTTTTATTGGAATACAACCAT
ACCCTTTTGTTTATGTATATCTGTGGCTGTTCTTTTTTTTTTTTTTTTTGGAGACGGGGTCTTGCTCTGTTGCCCAGGTTGGAGTGCAGT
GGCACAAACAGGGCTCACTGCATCCTCAAACTCTTAGGCTTAATTTATCCTCCTTCCTCAGCCCCCCAAGTAGTTGGAACCACAGGTGCA
CGTCACCACACTCAGCTAATTTTTTTTTTTTGAGACGGAGTCTCGCTCTGTCGCCCAGGCTGGAGTGCAGTGCCGCCATCTCTGCTCACT
GCAAGTTCTGCCCCCTGGGTTCACACCATTCTCCTGCCTCAGCCTCCTGAGTAGCTGGGACTACAGGCGCCCGCCACCATGGCCGGCTAA
TTTTTTAGTATTTTTAGTAGAGACAGGGTTTCACCGTGTTTGCCAGGATAGTCTCAATCTCCTGACCTCATGATCCACCTGCCTCGGCCT
CCCAAAGTGCTGGGATTACAGGCATGAGTCACCGCGCCCAGCCATCAGATAATTTTTAAAGTTTTTGTAGAAAGGGTGTCGCTGTGTTAC
CCAGGCTGGTCTTGAACTCCTGGGCTCAAGTGATCTTCCCGCCTCGGCCTCCCCAAGCGCTGGGGTGACAGGTGTGAGCCGCCACACGCG
GCCTGTGGCTGTTCTGAGCACTCACGTGGCCTTTGGCTCATAGAGTCTGAGATGCTTACTCTCTCGCCCTTTACAGGAATCGTTTGCTGA
AACCCTGTTCTCACTCCCACTTTCCTTTCTGTCATTGAGAGTCCTGGCTCTCATCAGCCACCGTGTATTCCAATTATTTGCTTTGCCCTA
GAGTCCACAGAAAATAGCTTTAGGTGTGTTAACCTATACCATTGTGAAAACATCTACTGCCTAGAGCCTGTTCACACGGTAATGGTGCAC
AGTCCTTTTTGTCTTTCTCCTTAGAGCACCTAGTCACTCACTGTTTTCCAAAGTTACGTAGGTTAGCTTCCCCTGTGTTACTCACTTGTA
ATACAGTTAGGTGCATTTCTTCTGGCTAGTATTCCATGTGGGTGTCTCCCCCATCTTTTTGTTTATTTACTTATTTCTTTTTTTTTTGTT
TTTTTTGTTGTTGTTGTTTTATTGAGGTGGAGTCTCGCTCTGTTGCCCAGGCTGGAGTGTAGTGGTGCGATCTCGGCTCACTGTGACCTC
TGCCTCCTGGGTTCCAGCGAGTCTCCTGCCTCAGGTTCCCGAGTAGCTGGGATTACAGGTGCCCGCCACTGCGCCTGTCTAATTTTTGTA
TTTTTTTTTTAGTAGAGATGGGGTTTCACCATCTTGGCCAGGCTGGTCTCGAACTGCTGACCTCGTGATCCACCCACCTCGGTCTCCCAA
AGTGCTGCGATTACAGGCGTGAGCCACCGCACCCGGCTTTACTTATTTGAGTATGTAAATCACGAACATGTTTTTAAAAGTCAGAACCCT
GTAGAAACTTAAATTCAGATGTATTACTCCCCCCCGCCATCTTTTTTTTTGTTGTTGTTGTTGAGACAGGGTCTGATTCTGTCACCCAGG
CTGGAGTGCAGGGTTGCCATCTCAGCTCGTGGTGGCATCCACCTCCCAGGCTCAAGTGATCCTCCTGCCTCAGCCCCCTGAGTAGCTGGG
GCTGTAGGTGTGCACTACTATGCTCGGGTAATTTTTTTTTTTTGAAACAAGGTCTTGCTCTTGTCCCCTAGGCTGGAGTGCAGTGGCGTG
ATTTCGGCTCACTGCAACCTCCACCTACTGGGTTCAAGCAATTCTCTTGCCTCAGCCTCCCGAGTAGCTGGGGTTACAGGCATGTACCAC
CACGCCCGGCTAATTTTTGTATTTTTAGTAGAGACAGGGTTTCACCATGTTGGCCAGGCTGGTCTCGAACTCCCGACCTCAGGTGATCTG
CCTGCCTCCCAAAGAATACAACGGGCTGGGCATGGTGGCTTATGCCTGTAATCCCAGCACTTTGGGAGGTTGGGAGTTCAAGACCAGCCT
GACCAACATGGAGAAACCCCGTCTCTACTAAAAGTACAAAATTAGCTGGGCGTGGTGGTGCACGCCTGTAATCCCAGCTACTCGGGAGGC
TTGAGGCAGGAGAACCGCTTGAACCCAGGAGGCAGAGGTTGCAGTGAGCTGAGATCGCACCACTGCACTCCAGCCTGCCTGGTGACAGAG
CGAGACTCCGTCTCAAAAAGAAAAAAGGCTCACGCCTGTAATCCAAACACTTTGGGAGGCCAAGGCAGGTGGATCACCTGAGGTCGGGAG
TGCAAGACCAACCTGGCCAACATGGTGAAACCCCGTCTCTCCTAAAAATACAAAAATTAGCTAGGTGTGATTCCAGGCGCCTGTAGTCCC
AGCTACTTGGGAGGCTGAGGCTGGAGAATCACTTGAACTCAGGAGGTAGAGGTTGCAGTGAGCTGCGATAGCACCACTGCACTCCAGCCT
GTGCGACAGAGGGAGACACCATCTCGAAAAAAAAAAGAAAAATTCTTTTTTTTTTTTTGAGCTGGAGTTTCGCTCTTGTTGTCTAAGCTG
GAGTGCAGGGGTGTGATCTCGGCTAATTGCAGCCTCCGCCTCCTGGGTTCAAGCGATTCTCCAGCCTCAGCCTCCCAAGTAGCTGGGATT
ACAGGCATCCGCCACCACACCCGGCTAATTTTTTGTATTTTCAGTAGAGACGTGGTTTCACCATGTTGGCCGGGCTGGTCTCGAACTCCT
GACCTCAGATGATCCGCCCGCCTCAGCCTCCCAAAATGCTGGGATTACAGGCGTGAGCCACCGCGTCCAGCCAAGAAAAAAAGTTTTTAA
TGAAAGAAACAGAAACTGATGCCATTATATAATGAACCCTAGTACCCATCACCCAGCTTCAGCAGGTGTTAGTATTTTGTGACTCTTTGA
TTTTTTTGTCTTGGGCCTAGGTGAAATGACAATGGATGCTCTGTTGGCTCGATTGAAACTTCTGAATCCAGATGACCTTAGAGAAGAAAT
CGTCAAAGCCGGATTGAAATGTGGACCCATTACATCAACTACAAGGTTCATTTTTGAGAAAAAATTGGCTCAGGCTTTACTGGAGCAAGG
AGGAAGGCTGTCTTCTTTCTACCACCATGAGGCAGGTGTCACAGCTCTCAGCCAGGACCCACAAAGGATTTTGAAGCCAGCTGAAGGGAA
CCCAACTGATCAGGCTGGTTTTTCTGAAGACAGAGATTTTGGTTACAGTGTGGGCCTGAATCCTCCAGAGGAGGAAGCTGTGACATCCAA
GACCTGCTCGGTGCCCCCTAGTGACACCGACACCTACAGAGCTGGAGCGACTGCGTCTAAGGAGCCGCCCCTGTACTATGGGGTGTGTCC
AGTGTATGAGGACGTCCCAGCGAGAAATGAAAGGATCTATGTTTATGAAAATAAAAAGGAAGCATTGCAAGCTGTCAAGATGATCAAAGG
GTCCCGATTTAAAGCTTTTTCTACCAGAGAAGACGCTGAGAAATTTGCTAGAGGAATTTGTGATTATTTCCCTTCTCCAAGCAAAACGTC
CTTACCACTGTCTCCTGTGAAAACAGCTCCACTCTTTAGCAATGACAGGTTGAAAGATGGTTTGTGCTTGTCGGAATCAGAAACAGTCAA
CAAAGAGCGAGCGAACAGTTACAAAAATCCCCGCACGCAGGACCTCACCGCCAAGCTTCGGAAAGCTGTGGAGAAGGGAGAGGAGGACAC
CTTTTCTGACCTTATCTGGAGCAACCCCCGGTATCTGATAGGCTCAGGAGACAACCCCACTATCGTGCAGGAAGGGTGCAGGTACAACGT
GATGCATGTTGCTGCCAAAGAGAACCAGGCTTCCATCTGCCAGCTGACTCTGGACGTCCTGGAGAACCCTGACTTCATGAGGCTGATGTA
CCCTGATGACGACGAGGCCATGCTGCAGAAGCGTATCCGTTACGTGGTGGACCTGTACCTCAACACCCCCGACAAGATGACTGAGGCTGA
TGTGAATCCAAAGGCCTATCCCCTTGCCGATGCCCACCTCACCAAGAAGCTACTGGACCTCGTTCAGCAGTCATGTAACTATAAGCAGCT
TCGGAAAGGAGCCAATGAGGCCACCAAAACCCTCAACAGGGGCATCTCTGAGTTCATCGTGATGGCTGCAGACGCCGAGCCACTGGAGAT
CATTCTGCACCTGCCGCTGCTGTGTGAAGACAAGAATGTGCCCTACGTGTTTGTGCGCTCCAAGCAGGCCCTGGGGAGAGCCTGTGGGGT
CTCCAGGCCTGTCATCGCCTGTTCTGTCACCATCAAAGAAGGCTCGCAGCTGAAACAGCAGATCCAATCCATTCAGCAGTCCATTGAAAG
GCTCTTAGTCTAAACCTGTGGCCTCTGCCACGTGCTCCCTGCCAGCTTCCCCCCTGAGGTTGTGTATCATATTATCTGTGTTAGCATGTA
GTATTTTCAGCTACTCTCTATTGTTATAAAATGTAGTACTAAATCTGGTTTCTGGATTTTTGTGTTGTTTTTGTTCTGTTTTACAGGGTT
GCTATCCCCCTTCCTTTCCTCCCTCCCTCTGCCATCCTTCATCCTTTTATCCTCCCTTTTTGGAACAAGTGTTCAGAGCAGACAGAAGCA
GGGTGGTGGCACCGTTGAAAGGCAGAAAGAGCCAGGAGAAAGCTGATGGAGCCAGGACAGAGATCTGGTTCCAGCTTTCAGCCACTAGCT
TCCTGTTGTGTGCGGGGTGTGGTGGAATTAAACAGCATTCATTGTGTGTCCCTGTGCCTGGCACACAGAATCATTCATACGTGTTCAAGT
GATCAAGGGGTTTCATTTGCTCTTGGGGGATTAGGTATCATTTGGGGAGGAAGCATGTGTTCTGTGAGGTTGTTCGGCTATGTCCAAGTG
TCGTTTACTAATGTACCCCTGCTGTTTGCTTTTGGTAATGTGATGTTGATGTTCTCCCCCTACCCACAACCATGCCCTTGAGGGTAGCAG
GGCAGCAGCATACCAAAGAGATGTGCTGCAGGACTCCGGAGGCAGCCTGGGTGGGTGAGCCATGGGGCAGTTGACCTGGGTCTTGAAAGA
GTCGGGAGTGACAAGCTCAGAGAGCATGAACTGATGCTGGCATGAAGGATTCCAGGAAGATCATGGAGACCTGGCTGGTAGCTGTAACAG
AGATGGTGGAGTCCAAGGAAACAGCCTGTCTCTGGTGAATGGGACTTTCTTTGGTGGACACTTGGCACCAGCTCTGAGAGCCCTTCCCCT
GTGTCCTGCCACCATGTGGGTCAGATGTACTCTCTGTCACATGAGGAGAGTGCTAGTTCATGTGTTCTCCATTCTTGTGAGCATCCTAAT

>4500_4500_7_ANKLE2-NHP2L1_ANKLE2_chr12_133324417_ENST00000539605_NHP2L1_chr22_42076368_ENST00000215956_length(amino acids)=480AA_BP=353
MGLGEMTMDALLARLKLLNPDDLREEIVKAGLKCGPITSTTRFIFEKKLAQALLEQGGRLSSFYHHEAGVTALSQDPQRILKPAEGNPTD
QAGFSEDRDFGYSVGLNPPEEEAVTSKTCSVPPSDTDTYRAGATASKEPPLYYGVCPVYEDVPARNERIYVYENKKEALQAVKMIKGSRF
KAFSTREDAEKFARGICDYFPSPSKTSLPLSPVKTAPLFSNDRLKDGLCLSESETVNKERANSYKNPRTQDLTAKLRKAVEKGEEDTFSD
LIWSNPRYLIGSGDNPTIVQEGCRYNVMHVAAKENQASICQLTLDVLENPDFMRLMYPDDDEAMLQKRIRYVVDLYLNTPDKMTEADVNP
KAYPLADAHLTKKLLDLVQQSCNYKQLRKGANEATKTLNRGISEFIVMAADAEPLEIILHLPLLCEDKNVPYVFVRSKQALGRACGVSRP

--------------------------------------------------------------
>4500_4500_8_ANKLE2-NHP2L1_ANKLE2_chr12_133324417_ENST00000539605_NHP2L1_chr22_42076368_ENST00000355257_length(transcript)=9116nt_BP=7729nt
GCCCGGGCGGCGGCGATGCTGTGGCCGCGGCTGGCGGCGGCCGAGTGGGCGGCGCTGGCCTGGGAGCTGCTGGGCGCCTCGGTGCTGCTG
ATCGCTGTGCGGTGGCTGGTGCGGCGGCTGGGCCCGCGGCCGGGAGGTCTGGGCCGCAGCGGGACCCCAGTTCCTCCGCCAAGCGCGGCC
GCCGCCCCCGCCTCAGGTAAGGCCCAGGCGGTCGCTGGGTCCCCGCACCCTGGCCCCTTCCCCGCCCCGACGCCCTCCTCGGGCCTGGGG
TCCCGGCCGCGCCCCTGGAGCCGGCAGCAGTTGGGCGAGGCGGCCGGGGAAACCAGGGCCGGTCGGGAAAGGCCATTCCGGCCGCGGAAA
GGGCAGTTGCGGGGACTTGGCTTCCCGGGCCGGGGGCGGAGGGGCCACGCCGGGTTCGGGGGTGAGAGCTTTCCCGGGCCCTGGAGCAGC
CTCCGGGGAAGGCGGCGGGGGCCCGGCGAGGCGTTAGCGGAGACTCTTGCTGCGGTCTCTCGAGACCTGGGGAGGGATGGCCCAAAGGAG
GGCGGCGCGGGGAGGAAACCCCTGGGTCCCGGATGTGTTTGGAACGTGAAGCCATTGCGGTTACTGGTCATGGAACATAAGGCAGAGACG
GAAAAGGCAAATGTAACTCAGGGGTTTGGGGCCAGAGGAAGAGGGAGAAGGTGGCCATTTATTGCTTTGCGGTAGACTGTCGGGTCTGGG
TGATGTGGAGATCAGAGGTGGGTTTTGGTCGTTTTAAGTTTGAGGTAACTGATACAGTGAACTGTGTATTTCAGCTCCATCCCCTTTTCC
TGGCATACAACTCTTGAAATCCCGGGAACCTCCAAAGTGATGTCTTTTGTAGGCTGAGTGGACTGGTGGCCGGCAGCCCCTAGGGAGCTT
CTGGATGGGGCTGGTCGCAGGAAAGACCAAGGCAGGGTTAGAGGTTCTGGGGACTTTCAGCCCCACCCCCAACCTCTGGGGAGGAGAGAG
GGGTGAAGGTTGCGTTGATCACCAGTGGCTGATGAATCACGCCTGTGAAATGAAGTTCCTGTAAAAACCCAAAAGGGCTGGGTTCAGGGA
GCTTCCAGATAGTACGTGGGGGTTCCTGGAGGCGGTGCCCAGAGAGGCCCTGAATTTCCAAGCGCTTCCCCCCGGTTTTACGTCACGCAT
CTCTTCACCTGTATTCTTTGTAATCCTTTATACTCTGCTGGTAAGTGTAAGTAAAACATGTCTGTGAGTTCGGGAGCCACTCTAGCAAAT
TACCGCAACCTGAGGAGGTCACCGGGTTACGCCCCGTCGGTCCCAAGCGCAGGTCAAACAACCTGGGCACTGGAAGTGGGGGGCAGTCTT
GCGGGGCTGAGCCGTTAACCTGTGGGGGTCTGCTGGTATCTCCAGGAAGACGCTGTCAGAATAGATGACTGAATTAGGATGACAGACGAC
ACCCAGCCTGTGTCCACTGCAGAACTGACGACCTGCGTGATTTGTGGGGAGAAAATCCCCACATACCTGGTGTCCGAAGCATGTTGCAAG
ACTAGTGGGAGAAACTGAGTTTGTTTTTACTCTAAATTGTCAGACTGTTAGTCACTGCGGAGAGGTGCTTTCTGATGATTGAGTGGGGAT
TCCTGTCCAATTGTGTGAGTTTGTGTCTCGGCCCTACCACTTTTTTTTTTTTTTTTTTTTGAAATGTAGTCTCGCCCTGTGGCCCAGGCT
GGAGTGCAGTGGCGCGATCTCGGCTCACTGCAAGCTCCGCCTCCCGGGTTCAAGCGATTCTCCTGCATCAGCCTCCCGAGTAGCTGGGAT
TACAGGCGCCTGCCACCACGCCCGGCTAATTTTTGTATTTTTAATAGAGACGGGGTTTCACCATGTTGGCCAGGATGGTCTCGAATTCCT
GACCTCAGGTGATCCACCTGCCTCAGCTTCCCAAAATGCTGGGATTACAGGTGTGAGCCATCGCACCGGGCCCTACCACTTATTGCTGTG
GGCTTAACCTGTTTTCAGCCTGCTCTTTTAGGAATGGGGATGATAGTGATACCTGGTTAGGCTTTTTTGGGAGTTGGGTAAGTGCAGCAC
TTGGTATGTGTTAAGCACCTCTGAGTGCTGTTACTGTCACCAGCGGCATCATCCAGGCAGAGCTGCGGACAAGGTGGCGGCGGGTGAGGG
TGGTGTTTTGAGAATGGCTGAAATAAAAAAATACTGATTTATTTTATATAAAAATATGTTTTTATATATGATGTATAATATACGTATATC
ATGGCATATGATACGTGTATATCATATAGCACATATAGTATACATATATATAGTCAGCAGAGATTTAGAGAAACTGGGCCTCGTGCATTG
CAGGTGGGGACGGTAAGTGGTGCAGCTACTCTGGGAATCAGCCTGGCAGGTTTTTAGGAAGTTAAACCTGCCCTGCATTCCTGAGCTTTT
ATTAGACAAATGAAAACTATTTTCACACAAAAACCCATATTTAATGTTCATAGCAACTTTATTTGTAATTACCAGAAACTGAAATAACTC
AAATGGTTAAACTTGCACACTGATACCCCGGGGTGCCACTCCGCAGCGATCCTCTCTGCCACGTGGGTGCCCCGGGGTGCCACTCTGCAT
GATCCACTCTGCCACGTGGGTGCCCCGGGGTGCCACTCCGCAGCGATCCTCTCTGCCACGTGGGTGCCCCGGGGTGCCACTCTGCGTGAT
CCACTCTGCCACGTGGGTGCCCCGGGGTGCCACTCCGCAGCGATCCTCTCTGCCACGTGGGTGCCCCGGGGTGCCACTCCGCAGCGATCC
ACTCTGCCACGTGGGTGCCCCGGGGTGCCACTCCGCAGCGATCCTCTCTGCCACGTGGGTGCCCCGGGGTGCCACACTGCGTGATCCACT
CTGCCACGTGGGTGCCCCGGGGTGCCACTCCGCAGCGATCCACTCTGCCACGTGGGTGGATCTCAAGGGCATTATGCTGAATAGGAAAAG
CCAGTCTCAAAAGTTGTGTACTTGGCCGGTTGCGGTGGCTCATGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGCAGGTGGATCACAAG
GTCAGGAGTTCAAGATCAGCCTGGCCAACATGGTGAGGCAGTCTCCACTAAAAATACAAAAAAATAGCGGGGCGTGGTGGCAGGTACCTG
TAATCCCAGCTACTCGGGAGGCTGAGGCAGCAGAATTGCTTGAACCCAGGAGGTGGAGGTTGCGGTGAGCAGAGATCGTGCCACTGCACT
CCAGCCTGGGCGACAGAGCAAGACTCCATCTCAAAAAAAAAAAAATTGTTAATGGAACATTATAACCCAGTGTTCAGACCTAGCTGTTTC
TCACATCTTTACCCATCGATCTGTCAAAGACCTTGTGATCATACTGATACTTCCAATTTCAATGCGACGTCCGCGGGTTTATTCTTTTTT
TTTTAGGTGGAGTCTCACTCTGTTGTCCAGGCTGGAGACTCACTGCAACCTCTGCCTGCCCAGTTCAAGCGATTCTCCCACCTAGCCTGC
TGAGTAGCTGGGATGACAGGTGCATGCCACCATGCCTGGCTAATTTTTGTGTTTTTAGTAGACACCTGGTTTCATCATGTTGGCCAGGCT
GGTCTCAAACACCTGACCTCAAATGATCCATGCACCTTGGCCTCCCAAAGTGCTGGGATTACCAGCATGAGCCACCGTGTCCGGCTCCCT
GGCTTTATTCTAATGCAAGAGTCAGTAAACTGTGGTCCAAACTGGCCCCCACCTATTTTCCTTAGTAAAGTTTTATTGGAATACAACCAT
ACCCTTTTGTTTATGTATATCTGTGGCTGTTCTTTTTTTTTTTTTTTTTGGAGACGGGGTCTTGCTCTGTTGCCCAGGTTGGAGTGCAGT
GGCACAAACAGGGCTCACTGCATCCTCAAACTCTTAGGCTTAATTTATCCTCCTTCCTCAGCCCCCCAAGTAGTTGGAACCACAGGTGCA
CGTCACCACACTCAGCTAATTTTTTTTTTTTGAGACGGAGTCTCGCTCTGTCGCCCAGGCTGGAGTGCAGTGCCGCCATCTCTGCTCACT
GCAAGTTCTGCCCCCTGGGTTCACACCATTCTCCTGCCTCAGCCTCCTGAGTAGCTGGGACTACAGGCGCCCGCCACCATGGCCGGCTAA
TTTTTTAGTATTTTTAGTAGAGACAGGGTTTCACCGTGTTTGCCAGGATAGTCTCAATCTCCTGACCTCATGATCCACCTGCCTCGGCCT
CCCAAAGTGCTGGGATTACAGGCATGAGTCACCGCGCCCAGCCATCAGATAATTTTTAAAGTTTTTGTAGAAAGGGTGTCGCTGTGTTAC
CCAGGCTGGTCTTGAACTCCTGGGCTCAAGTGATCTTCCCGCCTCGGCCTCCCCAAGCGCTGGGGTGACAGGTGTGAGCCGCCACACGCG
GCCTGTGGCTGTTCTGAGCACTCACGTGGCCTTTGGCTCATAGAGTCTGAGATGCTTACTCTCTCGCCCTTTACAGGAATCGTTTGCTGA
AACCCTGTTCTCACTCCCACTTTCCTTTCTGTCATTGAGAGTCCTGGCTCTCATCAGCCACCGTGTATTCCAATTATTTGCTTTGCCCTA
GAGTCCACAGAAAATAGCTTTAGGTGTGTTAACCTATACCATTGTGAAAACATCTACTGCCTAGAGCCTGTTCACACGGTAATGGTGCAC
AGTCCTTTTTGTCTTTCTCCTTAGAGCACCTAGTCACTCACTGTTTTCCAAAGTTACGTAGGTTAGCTTCCCCTGTGTTACTCACTTGTA
ATACAGTTAGGTGCATTTCTTCTGGCTAGTATTCCATGTGGGTGTCTCCCCCATCTTTTTGTTTATTTACTTATTTCTTTTTTTTTTGTT
TTTTTTGTTGTTGTTGTTTTATTGAGGTGGAGTCTCGCTCTGTTGCCCAGGCTGGAGTGTAGTGGTGCGATCTCGGCTCACTGTGACCTC
TGCCTCCTGGGTTCCAGCGAGTCTCCTGCCTCAGGTTCCCGAGTAGCTGGGATTACAGGTGCCCGCCACTGCGCCTGTCTAATTTTTGTA
TTTTTTTTTTAGTAGAGATGGGGTTTCACCATCTTGGCCAGGCTGGTCTCGAACTGCTGACCTCGTGATCCACCCACCTCGGTCTCCCAA
AGTGCTGCGATTACAGGCGTGAGCCACCGCACCCGGCTTTACTTATTTGAGTATGTAAATCACGAACATGTTTTTAAAAGTCAGAACCCT
GTAGAAACTTAAATTCAGATGTATTACTCCCCCCCGCCATCTTTTTTTTTGTTGTTGTTGTTGAGACAGGGTCTGATTCTGTCACCCAGG
CTGGAGTGCAGGGTTGCCATCTCAGCTCGTGGTGGCATCCACCTCCCAGGCTCAAGTGATCCTCCTGCCTCAGCCCCCTGAGTAGCTGGG
GCTGTAGGTGTGCACTACTATGCTCGGGTAATTTTTTTTTTTTGAAACAAGGTCTTGCTCTTGTCCCCTAGGCTGGAGTGCAGTGGCGTG
ATTTCGGCTCACTGCAACCTCCACCTACTGGGTTCAAGCAATTCTCTTGCCTCAGCCTCCCGAGTAGCTGGGGTTACAGGCATGTACCAC
CACGCCCGGCTAATTTTTGTATTTTTAGTAGAGACAGGGTTTCACCATGTTGGCCAGGCTGGTCTCGAACTCCCGACCTCAGGTGATCTG
CCTGCCTCCCAAAGAATACAACGGGCTGGGCATGGTGGCTTATGCCTGTAATCCCAGCACTTTGGGAGGTTGGGAGTTCAAGACCAGCCT
GACCAACATGGAGAAACCCCGTCTCTACTAAAAGTACAAAATTAGCTGGGCGTGGTGGTGCACGCCTGTAATCCCAGCTACTCGGGAGGC
TTGAGGCAGGAGAACCGCTTGAACCCAGGAGGCAGAGGTTGCAGTGAGCTGAGATCGCACCACTGCACTCCAGCCTGCCTGGTGACAGAG
CGAGACTCCGTCTCAAAAAGAAAAAAGGCTCACGCCTGTAATCCAAACACTTTGGGAGGCCAAGGCAGGTGGATCACCTGAGGTCGGGAG
TGCAAGACCAACCTGGCCAACATGGTGAAACCCCGTCTCTCCTAAAAATACAAAAATTAGCTAGGTGTGATTCCAGGCGCCTGTAGTCCC
AGCTACTTGGGAGGCTGAGGCTGGAGAATCACTTGAACTCAGGAGGTAGAGGTTGCAGTGAGCTGCGATAGCACCACTGCACTCCAGCCT
GTGCGACAGAGGGAGACACCATCTCGAAAAAAAAAAGAAAAATTCTTTTTTTTTTTTTGAGCTGGAGTTTCGCTCTTGTTGTCTAAGCTG
GAGTGCAGGGGTGTGATCTCGGCTAATTGCAGCCTCCGCCTCCTGGGTTCAAGCGATTCTCCAGCCTCAGCCTCCCAAGTAGCTGGGATT
ACAGGCATCCGCCACCACACCCGGCTAATTTTTTGTATTTTCAGTAGAGACGTGGTTTCACCATGTTGGCCGGGCTGGTCTCGAACTCCT
GACCTCAGATGATCCGCCCGCCTCAGCCTCCCAAAATGCTGGGATTACAGGCGTGAGCCACCGCGTCCAGCCAAGAAAAAAAGTTTTTAA
TGAAAGAAACAGAAACTGATGCCATTATATAATGAACCCTAGTACCCATCACCCAGCTTCAGCAGGTGTTAGTATTTTGTGACTCTTTGA
TTTTTTTGTCTTGGGCCTAGGTGAAATGACAATGGATGCTCTGTTGGCTCGATTGAAACTTCTGAATCCAGATGACCTTAGAGAAGAAAT
CGTCAAAGCCGGATTGAAATGTGGACCCATTACATCAACTACAAGGTTCATTTTTGAGAAAAAATTGGCTCAGGCTTTACTGGAGCAAGG
AGGAAGGCTGTCTTCTTTCTACCACCATGAGGCAGGTGTCACAGCTCTCAGCCAGGACCCACAAAGGATTTTGAAGCCAGCTGAAGGGAA
CCCAACTGATCAGGCTGGTTTTTCTGAAGACAGAGATTTTGGTTACAGTGTGGGCCTGAATCCTCCAGAGGAGGAAGCTGTGACATCCAA
GACCTGCTCGGTGCCCCCTAGTGACACCGACACCTACAGAGCTGGAGCGACTGCGTCTAAGGAGCCGCCCCTGTACTATGGGGTGTGTCC
AGTGTATGAGGACGTCCCAGCGAGAAATGAAAGGATCTATGTTTATGAAAATAAAAAGGAAGCATTGCAAGCTGTCAAGATGATCAAAGG
GTCCCGATTTAAAGCTTTTTCTACCAGAGAAGACGCTGAGAAATTTGCTAGAGGAATTTGTGATTATTTCCCTTCTCCAAGCAAAACGTC
CTTACCACTGTCTCCTGTGAAAACAGCTCCACTCTTTAGCAATGACAGGTTGAAAGATGGTTTGTGCTTGTCGGAATCAGAAACAGTCAA
CAAAGAGCGAGCGAACAGTTACAAAAATCCCCGCACGCAGGACCTCACCGCCAAGCTTCGGAAAGCTGTGGAGAAGGGAGAGGAGGACAC
CTTTTCTGACCTTATCTGGAGCAACCCCCGGTATCTGATAGGCTCAGGAGACAACCCCACTATCGTGCAGGAAGGGTGCAGGTACAACGT
GATGCATGTTGCTGCCAAAGAGAACCAGGCTTCCATCTGCCAGCTGACTCTGGACGTCCTGGAGAACCCTGACTTCATGAGGCTGATGTA
CCCTGATGACGACGAGGCCATGCTGCAGAAGCGTATCCGTTACGTGGTGGACCTGTACCTCAACACCCCCGACAAGATGACTGAGGCTGA
TGTGAATCCAAAGGCCTATCCCCTTGCCGATGCCCACCTCACCAAGAAGCTACTGGACCTCGTTCAGCAGTCATGTAACTATAAGCAGCT
TCGGAAAGGAGCCAATGAGGCCACCAAAACCCTCAACAGGGGCATCTCTGAGTTCATCGTGATGGCTGCAGACGCCGAGCCACTGGAGAT
CATTCTGCACCTGCCGCTGCTGTGTGAAGACAAGAATGTGCCCTACGTGTTTGTGCGCTCCAAGCAGGCCCTGGGGAGAGCCTGTGGGGT
CTCCAGGCCTGTCATCGCCTGTTCTGTCACCATCAAAGAAGGCTCGCAGCTGAAACAGCAGATCCAATCCATTCAGCAGTCCATTGAAAG
GCTCTTAGTCTAAACCTGTGGCCTCTGCCACGTGCTCCCTGCCAGCTTCCCCCCTGAGGTTGTGTATCATATTATCTGTGTTAGCATGTA
GTATTTTCAGCTACTCTCTATTGTTATAAAATGTAGTACTAAATCTGGTTTCTGGATTTTTGTGTTGTTTTTGTTCTGTTTTACAGGGTT
GCTATCCCCCTTCCTTTCCTCCCTCCCTCTGCCATCCTTCATCCTTTTATCCTCCCTTTTTGGAACAAGTGTTCAGAGCAGACAGAAGCA
GGGTGGTGGCACCGTTGAAAGGCAGAAAGAGCCAGGAGAAAGCTGATGGAGCCAGGACAGAGATCTGGTTCCAGCTTTCAGCCACTAGCT
TCCTGTTGTGTGCGGGGTGTGGTGGAATTAAACAGCATTCATTGTGTGTCCCTGTGCCTGGCACACAGAATCATTCATACGTGTTCAAGT
GATCAAGGGGTTTCATTTGCTCTTGGGGGATTAGGTATCATTTGGGGAGGAAGCATGTGTTCTGTGAGGTTGTTCGGCTATGTCCAAGTG
TCGTTTACTAATGTACCCCTGCTGTTTGCTTTTGGTAATGTGATGTTGATGTTCTCCCCCTACCCACAACCATGCCCTTGAGGGTAGCAG
GGCAGCAGCATACCAAAGAGATGTGCTGCAGGACTCCGGAGGCAGCCTGGGTGGGTGAGCCATGGGGCAGTTGACCTGGGTCTTGAAAGA
GTCGGGAGTGACAAGCTCAGAGAGCATGAACTGATGCTGGCATGAAGGATTCCAGGAAGATCATGGAGACCTGGCTGGTAGCTGTAACAG
AGATGGTGGAGTCCAAGGAAACAGCCTGTCTCTGGTGAATGGGACTTTCTTTGGTGGACACTTGGCACCAGCTCTGAGAGCCCTTCCCCT
GTGTCCTGCCACCATGTGGGTCAGATGTACTCTCTGTCACATGAGGAGAGTGCTAGTTCATGTGTTCTCCATTCTTGTGAGCATCCTAAT

>4500_4500_8_ANKLE2-NHP2L1_ANKLE2_chr12_133324417_ENST00000539605_NHP2L1_chr22_42076368_ENST00000355257_length(amino acids)=480AA_BP=353
MGLGEMTMDALLARLKLLNPDDLREEIVKAGLKCGPITSTTRFIFEKKLAQALLEQGGRLSSFYHHEAGVTALSQDPQRILKPAEGNPTD
QAGFSEDRDFGYSVGLNPPEEEAVTSKTCSVPPSDTDTYRAGATASKEPPLYYGVCPVYEDVPARNERIYVYENKKEALQAVKMIKGSRF
KAFSTREDAEKFARGICDYFPSPSKTSLPLSPVKTAPLFSNDRLKDGLCLSESETVNKERANSYKNPRTQDLTAKLRKAVEKGEEDTFSD
LIWSNPRYLIGSGDNPTIVQEGCRYNVMHVAAKENQASICQLTLDVLENPDFMRLMYPDDDEAMLQKRIRYVVDLYLNTPDKMTEADVNP
KAYPLADAHLTKKLLDLVQQSCNYKQLRKGANEATKTLNRGISEFIVMAADAEPLEIILHLPLLCEDKNVPYVFVRSKQALGRACGVSRP

--------------------------------------------------------------
>4500_4500_9_ANKLE2-NHP2L1_ANKLE2_chr12_133324417_ENST00000539605_NHP2L1_chr22_42076368_ENST00000401959_length(transcript)=9079nt_BP=7729nt
GCCCGGGCGGCGGCGATGCTGTGGCCGCGGCTGGCGGCGGCCGAGTGGGCGGCGCTGGCCTGGGAGCTGCTGGGCGCCTCGGTGCTGCTG
ATCGCTGTGCGGTGGCTGGTGCGGCGGCTGGGCCCGCGGCCGGGAGGTCTGGGCCGCAGCGGGACCCCAGTTCCTCCGCCAAGCGCGGCC
GCCGCCCCCGCCTCAGGTAAGGCCCAGGCGGTCGCTGGGTCCCCGCACCCTGGCCCCTTCCCCGCCCCGACGCCCTCCTCGGGCCTGGGG
TCCCGGCCGCGCCCCTGGAGCCGGCAGCAGTTGGGCGAGGCGGCCGGGGAAACCAGGGCCGGTCGGGAAAGGCCATTCCGGCCGCGGAAA
GGGCAGTTGCGGGGACTTGGCTTCCCGGGCCGGGGGCGGAGGGGCCACGCCGGGTTCGGGGGTGAGAGCTTTCCCGGGCCCTGGAGCAGC
CTCCGGGGAAGGCGGCGGGGGCCCGGCGAGGCGTTAGCGGAGACTCTTGCTGCGGTCTCTCGAGACCTGGGGAGGGATGGCCCAAAGGAG
GGCGGCGCGGGGAGGAAACCCCTGGGTCCCGGATGTGTTTGGAACGTGAAGCCATTGCGGTTACTGGTCATGGAACATAAGGCAGAGACG
GAAAAGGCAAATGTAACTCAGGGGTTTGGGGCCAGAGGAAGAGGGAGAAGGTGGCCATTTATTGCTTTGCGGTAGACTGTCGGGTCTGGG
TGATGTGGAGATCAGAGGTGGGTTTTGGTCGTTTTAAGTTTGAGGTAACTGATACAGTGAACTGTGTATTTCAGCTCCATCCCCTTTTCC
TGGCATACAACTCTTGAAATCCCGGGAACCTCCAAAGTGATGTCTTTTGTAGGCTGAGTGGACTGGTGGCCGGCAGCCCCTAGGGAGCTT
CTGGATGGGGCTGGTCGCAGGAAAGACCAAGGCAGGGTTAGAGGTTCTGGGGACTTTCAGCCCCACCCCCAACCTCTGGGGAGGAGAGAG
GGGTGAAGGTTGCGTTGATCACCAGTGGCTGATGAATCACGCCTGTGAAATGAAGTTCCTGTAAAAACCCAAAAGGGCTGGGTTCAGGGA
GCTTCCAGATAGTACGTGGGGGTTCCTGGAGGCGGTGCCCAGAGAGGCCCTGAATTTCCAAGCGCTTCCCCCCGGTTTTACGTCACGCAT
CTCTTCACCTGTATTCTTTGTAATCCTTTATACTCTGCTGGTAAGTGTAAGTAAAACATGTCTGTGAGTTCGGGAGCCACTCTAGCAAAT
TACCGCAACCTGAGGAGGTCACCGGGTTACGCCCCGTCGGTCCCAAGCGCAGGTCAAACAACCTGGGCACTGGAAGTGGGGGGCAGTCTT
GCGGGGCTGAGCCGTTAACCTGTGGGGGTCTGCTGGTATCTCCAGGAAGACGCTGTCAGAATAGATGACTGAATTAGGATGACAGACGAC
ACCCAGCCTGTGTCCACTGCAGAACTGACGACCTGCGTGATTTGTGGGGAGAAAATCCCCACATACCTGGTGTCCGAAGCATGTTGCAAG
ACTAGTGGGAGAAACTGAGTTTGTTTTTACTCTAAATTGTCAGACTGTTAGTCACTGCGGAGAGGTGCTTTCTGATGATTGAGTGGGGAT
TCCTGTCCAATTGTGTGAGTTTGTGTCTCGGCCCTACCACTTTTTTTTTTTTTTTTTTTTGAAATGTAGTCTCGCCCTGTGGCCCAGGCT
GGAGTGCAGTGGCGCGATCTCGGCTCACTGCAAGCTCCGCCTCCCGGGTTCAAGCGATTCTCCTGCATCAGCCTCCCGAGTAGCTGGGAT
TACAGGCGCCTGCCACCACGCCCGGCTAATTTTTGTATTTTTAATAGAGACGGGGTTTCACCATGTTGGCCAGGATGGTCTCGAATTCCT
GACCTCAGGTGATCCACCTGCCTCAGCTTCCCAAAATGCTGGGATTACAGGTGTGAGCCATCGCACCGGGCCCTACCACTTATTGCTGTG
GGCTTAACCTGTTTTCAGCCTGCTCTTTTAGGAATGGGGATGATAGTGATACCTGGTTAGGCTTTTTTGGGAGTTGGGTAAGTGCAGCAC
TTGGTATGTGTTAAGCACCTCTGAGTGCTGTTACTGTCACCAGCGGCATCATCCAGGCAGAGCTGCGGACAAGGTGGCGGCGGGTGAGGG
TGGTGTTTTGAGAATGGCTGAAATAAAAAAATACTGATTTATTTTATATAAAAATATGTTTTTATATATGATGTATAATATACGTATATC
ATGGCATATGATACGTGTATATCATATAGCACATATAGTATACATATATATAGTCAGCAGAGATTTAGAGAAACTGGGCCTCGTGCATTG
CAGGTGGGGACGGTAAGTGGTGCAGCTACTCTGGGAATCAGCCTGGCAGGTTTTTAGGAAGTTAAACCTGCCCTGCATTCCTGAGCTTTT
ATTAGACAAATGAAAACTATTTTCACACAAAAACCCATATTTAATGTTCATAGCAACTTTATTTGTAATTACCAGAAACTGAAATAACTC
AAATGGTTAAACTTGCACACTGATACCCCGGGGTGCCACTCCGCAGCGATCCTCTCTGCCACGTGGGTGCCCCGGGGTGCCACTCTGCAT
GATCCACTCTGCCACGTGGGTGCCCCGGGGTGCCACTCCGCAGCGATCCTCTCTGCCACGTGGGTGCCCCGGGGTGCCACTCTGCGTGAT
CCACTCTGCCACGTGGGTGCCCCGGGGTGCCACTCCGCAGCGATCCTCTCTGCCACGTGGGTGCCCCGGGGTGCCACTCCGCAGCGATCC
ACTCTGCCACGTGGGTGCCCCGGGGTGCCACTCCGCAGCGATCCTCTCTGCCACGTGGGTGCCCCGGGGTGCCACACTGCGTGATCCACT
CTGCCACGTGGGTGCCCCGGGGTGCCACTCCGCAGCGATCCACTCTGCCACGTGGGTGGATCTCAAGGGCATTATGCTGAATAGGAAAAG
CCAGTCTCAAAAGTTGTGTACTTGGCCGGTTGCGGTGGCTCATGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGCAGGTGGATCACAAG
GTCAGGAGTTCAAGATCAGCCTGGCCAACATGGTGAGGCAGTCTCCACTAAAAATACAAAAAAATAGCGGGGCGTGGTGGCAGGTACCTG
TAATCCCAGCTACTCGGGAGGCTGAGGCAGCAGAATTGCTTGAACCCAGGAGGTGGAGGTTGCGGTGAGCAGAGATCGTGCCACTGCACT
CCAGCCTGGGCGACAGAGCAAGACTCCATCTCAAAAAAAAAAAAATTGTTAATGGAACATTATAACCCAGTGTTCAGACCTAGCTGTTTC
TCACATCTTTACCCATCGATCTGTCAAAGACCTTGTGATCATACTGATACTTCCAATTTCAATGCGACGTCCGCGGGTTTATTCTTTTTT
TTTTAGGTGGAGTCTCACTCTGTTGTCCAGGCTGGAGACTCACTGCAACCTCTGCCTGCCCAGTTCAAGCGATTCTCCCACCTAGCCTGC
TGAGTAGCTGGGATGACAGGTGCATGCCACCATGCCTGGCTAATTTTTGTGTTTTTAGTAGACACCTGGTTTCATCATGTTGGCCAGGCT
GGTCTCAAACACCTGACCTCAAATGATCCATGCACCTTGGCCTCCCAAAGTGCTGGGATTACCAGCATGAGCCACCGTGTCCGGCTCCCT
GGCTTTATTCTAATGCAAGAGTCAGTAAACTGTGGTCCAAACTGGCCCCCACCTATTTTCCTTAGTAAAGTTTTATTGGAATACAACCAT
ACCCTTTTGTTTATGTATATCTGTGGCTGTTCTTTTTTTTTTTTTTTTTGGAGACGGGGTCTTGCTCTGTTGCCCAGGTTGGAGTGCAGT
GGCACAAACAGGGCTCACTGCATCCTCAAACTCTTAGGCTTAATTTATCCTCCTTCCTCAGCCCCCCAAGTAGTTGGAACCACAGGTGCA
CGTCACCACACTCAGCTAATTTTTTTTTTTTGAGACGGAGTCTCGCTCTGTCGCCCAGGCTGGAGTGCAGTGCCGCCATCTCTGCTCACT
GCAAGTTCTGCCCCCTGGGTTCACACCATTCTCCTGCCTCAGCCTCCTGAGTAGCTGGGACTACAGGCGCCCGCCACCATGGCCGGCTAA
TTTTTTAGTATTTTTAGTAGAGACAGGGTTTCACCGTGTTTGCCAGGATAGTCTCAATCTCCTGACCTCATGATCCACCTGCCTCGGCCT
CCCAAAGTGCTGGGATTACAGGCATGAGTCACCGCGCCCAGCCATCAGATAATTTTTAAAGTTTTTGTAGAAAGGGTGTCGCTGTGTTAC
CCAGGCTGGTCTTGAACTCCTGGGCTCAAGTGATCTTCCCGCCTCGGCCTCCCCAAGCGCTGGGGTGACAGGTGTGAGCCGCCACACGCG
GCCTGTGGCTGTTCTGAGCACTCACGTGGCCTTTGGCTCATAGAGTCTGAGATGCTTACTCTCTCGCCCTTTACAGGAATCGTTTGCTGA
AACCCTGTTCTCACTCCCACTTTCCTTTCTGTCATTGAGAGTCCTGGCTCTCATCAGCCACCGTGTATTCCAATTATTTGCTTTGCCCTA
GAGTCCACAGAAAATAGCTTTAGGTGTGTTAACCTATACCATTGTGAAAACATCTACTGCCTAGAGCCTGTTCACACGGTAATGGTGCAC
AGTCCTTTTTGTCTTTCTCCTTAGAGCACCTAGTCACTCACTGTTTTCCAAAGTTACGTAGGTTAGCTTCCCCTGTGTTACTCACTTGTA
ATACAGTTAGGTGCATTTCTTCTGGCTAGTATTCCATGTGGGTGTCTCCCCCATCTTTTTGTTTATTTACTTATTTCTTTTTTTTTTGTT
TTTTTTGTTGTTGTTGTTTTATTGAGGTGGAGTCTCGCTCTGTTGCCCAGGCTGGAGTGTAGTGGTGCGATCTCGGCTCACTGTGACCTC
TGCCTCCTGGGTTCCAGCGAGTCTCCTGCCTCAGGTTCCCGAGTAGCTGGGATTACAGGTGCCCGCCACTGCGCCTGTCTAATTTTTGTA
TTTTTTTTTTAGTAGAGATGGGGTTTCACCATCTTGGCCAGGCTGGTCTCGAACTGCTGACCTCGTGATCCACCCACCTCGGTCTCCCAA
AGTGCTGCGATTACAGGCGTGAGCCACCGCACCCGGCTTTACTTATTTGAGTATGTAAATCACGAACATGTTTTTAAAAGTCAGAACCCT
GTAGAAACTTAAATTCAGATGTATTACTCCCCCCCGCCATCTTTTTTTTTGTTGTTGTTGTTGAGACAGGGTCTGATTCTGTCACCCAGG
CTGGAGTGCAGGGTTGCCATCTCAGCTCGTGGTGGCATCCACCTCCCAGGCTCAAGTGATCCTCCTGCCTCAGCCCCCTGAGTAGCTGGG
GCTGTAGGTGTGCACTACTATGCTCGGGTAATTTTTTTTTTTTGAAACAAGGTCTTGCTCTTGTCCCCTAGGCTGGAGTGCAGTGGCGTG
ATTTCGGCTCACTGCAACCTCCACCTACTGGGTTCAAGCAATTCTCTTGCCTCAGCCTCCCGAGTAGCTGGGGTTACAGGCATGTACCAC
CACGCCCGGCTAATTTTTGTATTTTTAGTAGAGACAGGGTTTCACCATGTTGGCCAGGCTGGTCTCGAACTCCCGACCTCAGGTGATCTG
CCTGCCTCCCAAAGAATACAACGGGCTGGGCATGGTGGCTTATGCCTGTAATCCCAGCACTTTGGGAGGTTGGGAGTTCAAGACCAGCCT
GACCAACATGGAGAAACCCCGTCTCTACTAAAAGTACAAAATTAGCTGGGCGTGGTGGTGCACGCCTGTAATCCCAGCTACTCGGGAGGC
TTGAGGCAGGAGAACCGCTTGAACCCAGGAGGCAGAGGTTGCAGTGAGCTGAGATCGCACCACTGCACTCCAGCCTGCCTGGTGACAGAG
CGAGACTCCGTCTCAAAAAGAAAAAAGGCTCACGCCTGTAATCCAAACACTTTGGGAGGCCAAGGCAGGTGGATCACCTGAGGTCGGGAG
TGCAAGACCAACCTGGCCAACATGGTGAAACCCCGTCTCTCCTAAAAATACAAAAATTAGCTAGGTGTGATTCCAGGCGCCTGTAGTCCC
AGCTACTTGGGAGGCTGAGGCTGGAGAATCACTTGAACTCAGGAGGTAGAGGTTGCAGTGAGCTGCGATAGCACCACTGCACTCCAGCCT
GTGCGACAGAGGGAGACACCATCTCGAAAAAAAAAAGAAAAATTCTTTTTTTTTTTTTGAGCTGGAGTTTCGCTCTTGTTGTCTAAGCTG
GAGTGCAGGGGTGTGATCTCGGCTAATTGCAGCCTCCGCCTCCTGGGTTCAAGCGATTCTCCAGCCTCAGCCTCCCAAGTAGCTGGGATT
ACAGGCATCCGCCACCACACCCGGCTAATTTTTTGTATTTTCAGTAGAGACGTGGTTTCACCATGTTGGCCGGGCTGGTCTCGAACTCCT
GACCTCAGATGATCCGCCCGCCTCAGCCTCCCAAAATGCTGGGATTACAGGCGTGAGCCACCGCGTCCAGCCAAGAAAAAAAGTTTTTAA
TGAAAGAAACAGAAACTGATGCCATTATATAATGAACCCTAGTACCCATCACCCAGCTTCAGCAGGTGTTAGTATTTTGTGACTCTTTGA
TTTTTTTGTCTTGGGCCTAGGTGAAATGACAATGGATGCTCTGTTGGCTCGATTGAAACTTCTGAATCCAGATGACCTTAGAGAAGAAAT
CGTCAAAGCCGGATTGAAATGTGGACCCATTACATCAACTACAAGGTTCATTTTTGAGAAAAAATTGGCTCAGGCTTTACTGGAGCAAGG
AGGAAGGCTGTCTTCTTTCTACCACCATGAGGCAGGTGTCACAGCTCTCAGCCAGGACCCACAAAGGATTTTGAAGCCAGCTGAAGGGAA
CCCAACTGATCAGGCTGGTTTTTCTGAAGACAGAGATTTTGGTTACAGTGTGGGCCTGAATCCTCCAGAGGAGGAAGCTGTGACATCCAA
GACCTGCTCGGTGCCCCCTAGTGACACCGACACCTACAGAGCTGGAGCGACTGCGTCTAAGGAGCCGCCCCTGTACTATGGGGTGTGTCC
AGTGTATGAGGACGTCCCAGCGAGAAATGAAAGGATCTATGTTTATGAAAATAAAAAGGAAGCATTGCAAGCTGTCAAGATGATCAAAGG
GTCCCGATTTAAAGCTTTTTCTACCAGAGAAGACGCTGAGAAATTTGCTAGAGGAATTTGTGATTATTTCCCTTCTCCAAGCAAAACGTC
CTTACCACTGTCTCCTGTGAAAACAGCTCCACTCTTTAGCAATGACAGGTTGAAAGATGGTTTGTGCTTGTCGGAATCAGAAACAGTCAA
CAAAGAGCGAGCGAACAGTTACAAAAATCCCCGCACGCAGGACCTCACCGCCAAGCTTCGGAAAGCTGTGGAGAAGGGAGAGGAGGACAC
CTTTTCTGACCTTATCTGGAGCAACCCCCGGTATCTGATAGGCTCAGGAGACAACCCCACTATCGTGCAGGAAGGGTGCAGGTACAACGT
GATGCATGTTGCTGCCAAAGAGAACCAGGCTTCCATCTGCCAGCTGACTCTGGACGTCCTGGAGAACCCTGACTTCATGAGGCTGATGTA
CCCTGATGACGACGAGGCCATGCTGCAGAAGCGTATCCGTTACGTGGTGGACCTGTACCTCAACACCCCCGACAAGATGACTGAGGCTGA
TGTGAATCCAAAGGCCTATCCCCTTGCCGATGCCCACCTCACCAAGAAGCTACTGGACCTCGTTCAGCAGTCATGTAACTATAAGCAGCT
TCGGAAAGGAGCCAATGAGGCCACCAAAACCCTCAACAGGGGCATCTCTGAGTTCATCGTGATGGCTGCAGACGCCGAGCCACTGGAGAT
CATTCTGCACCTGCCGCTGCTGTGTGAAGACAAGAATGTGCCCTACGTGTTTGTGCGCTCCAAGCAGGCCCTGGGGAGAGCCTGTGGGGT
CTCCAGGCCTGTCATCGCCTGTTCTGTCACCATCAAAGAAGGCTCGCAGCTGAAACAGCAGATCCAATCCATTCAGCAGTCCATTGAAAG
GCTCTTAGTCTAAACCTGTGGCCTCTGCCACGTGCTCCCTGCCAGCTTCCCCCCTGAGGTTGTGTATCATATTATCTGTGTTAGCATGTA
GTATTTTCAGCTACTCTCTATTGTTATAAAATGTAGTACTAAATCTGGTTTCTGGATTTTTGTGTTGTTTTTGTTCTGTTTTACAGGGTT
GCTATCCCCCTTCCTTTCCTCCCTCCCTCTGCCATCCTTCATCCTTTTATCCTCCCTTTTTGGAACAAGTGTTCAGAGCAGACAGAAGCA
GGGTGGTGGCACCGTTGAAAGGCAGAAAGAGCCAGGAGAAAGCTGATGGAGCCAGGACAGAGATCTGGTTCCAGCTTTCAGCCACTAGCT
TCCTGTTGTGTGCGGGGTGTGGTGGAATTAAACAGCATTCATTGTGTGTCCCTGTGCCTGGCACACAGAATCATTCATACGTGTTCAAGT
GATCAAGGGGTTTCATTTGCTCTTGGGGGATTAGGTATCATTTGGGGAGGAAGCATGTGTTCTGTGAGGTTGTTCGGCTATGTCCAAGTG
TCGTTTACTAATGTACCCCTGCTGTTTGCTTTTGGTAATGTGATGTTGATGTTCTCCCCCTACCCACAACCATGCCCTTGAGGGTAGCAG
GGCAGCAGCATACCAAAGAGATGTGCTGCAGGACTCCGGAGGCAGCCTGGGTGGGTGAGCCATGGGGCAGTTGACCTGGGTCTTGAAAGA
GTCGGGAGTGACAAGCTCAGAGAGCATGAACTGATGCTGGCATGAAGGATTCCAGGAAGATCATGGAGACCTGGCTGGTAGCTGTAACAG
AGATGGTGGAGTCCAAGGAAACAGCCTGTCTCTGGTGAATGGGACTTTCTTTGGTGGACACTTGGCACCAGCTCTGAGAGCCCTTCCCCT

>4500_4500_9_ANKLE2-NHP2L1_ANKLE2_chr12_133324417_ENST00000539605_NHP2L1_chr22_42076368_ENST00000401959_length(amino acids)=480AA_BP=353
MGLGEMTMDALLARLKLLNPDDLREEIVKAGLKCGPITSTTRFIFEKKLAQALLEQGGRLSSFYHHEAGVTALSQDPQRILKPAEGNPTD
QAGFSEDRDFGYSVGLNPPEEEAVTSKTCSVPPSDTDTYRAGATASKEPPLYYGVCPVYEDVPARNERIYVYENKKEALQAVKMIKGSRF
KAFSTREDAEKFARGICDYFPSPSKTSLPLSPVKTAPLFSNDRLKDGLCLSESETVNKERANSYKNPRTQDLTAKLRKAVEKGEEDTFSD
LIWSNPRYLIGSGDNPTIVQEGCRYNVMHVAAKENQASICQLTLDVLENPDFMRLMYPDDDEAMLQKRIRYVVDLYLNTPDKMTEADVNP
KAYPLADAHLTKKLLDLVQQSCNYKQLRKGANEATKTLNRGISEFIVMAADAEPLEIILHLPLLCEDKNVPYVFVRSKQALGRACGVSRP

--------------------------------------------------------------
>4500_4500_10_ANKLE2-NHP2L1_ANKLE2_chr12_133324418_ENST00000337516_NHP2L1_chr22_42076368_ENST00000215956_length(transcript)=2660nt_BP=1297nt
GCGGGGTCCTGGGACGGGCGCGGCGCGGGGCGCGGGCTTCTCGGCGGCTGCGGCCCGGGCGGCGGCGATGCTGTGGCCGCGGCTGGCGGC
GGCCGAGTGGGCGGCGCTGGCCTGGGAGCTGCTGGGCGCCTCGGTGCTGCTGATCGCTGTGCGGTGGCTGGTGCGGCGGCTGGGCCCGCG
GCCGGGAGGTCTGGGCCGCAGCGGGACCCCAGTTCCTCCGCCAAGCGCGGCCGCCGCCCCCGCCTCAGGTGAAATGACAATGGATGCTCT
GTTGGCTCGATTGAAACTTCTGAATCCAGATGACCTTAGAGAAGAAATCGTCAAAGCCGGATTGAAATGTGGACCCATTACATCAACTAC
AAGGTTCATTTTTGAGAAAAAATTGGCTCAGGCTTTACTGGAGCAAGGAGGAAGGCTGTCTTCTTTCTACCACCATGAGGCAGGTGTCAC
AGCTCTCAGCCAGGACCCACAAAGGATTTTGAAGCCAGCTGAAGGGAACCCAACTGATCAGGCTGGTTTTTCTGAAGACAGAGATTTTGG
TTACAGTGTGGGCCTGAATCCTCCAGAGGAGGAAGCTGTGACATCCAAGACCTGCTCGGTGCCCCCTAGTGACACCGACACCTACAGAGC
TGGAGCGACTGCGTCTAAGGAGCCGCCCCTGTACTATGGGGTGTGTCCAGTGTATGAGGACGTCCCAGCGAGAAATGAAAGGATCTATGT
TTATGAAAATAAAAAGGAAGCATTGCAAGCTGTCAAGATGATCAAAGGGTCCCGATTTAAAGCTTTTTCTACCAGAGAAGACGCTGAGAA
ATTTGCTAGAGGAATTTGTGATTATTTCCCTTCTCCAAGCAAAACGTCCTTACCACTGTCTCCTGTGAAAACAGCTCCACTCTTTAGCAA
TGACAGGTTGAAAGATGGTTTGTGCTTGTCGGAATCAGAAACAGTCAACAAAGAGCGAGCGAACAGTTACAAAAATCCCCGCACGCAGGA
CCTCACCGCCAAGCTTCGGAAAGCTGTGGAGAAGGGAGAGGAGGACACCTTTTCTGACCTTATCTGGAGCAACCCCCGGTATCTGATAGG
CTCAGGAGACAACCCCACTATCGTGCAGGAAGGGTGCAGGTACAACGTGATGCATGTTGCTGCCAAAGAGAACCAGGCTTCCATCTGCCA
GCTGACTCTGGACGTCCTGGAGAACCCTGACTTCATGAGGCTGATGTACCCTGATGACGACGAGGCCATGCTGCAGAAGCGTATCCGTTA
CGTGGTGGACCTGTACCTCAACACCCCCGACAAGATGACTGAGGCTGATGTGAATCCAAAGGCCTATCCCCTTGCCGATGCCCACCTCAC
CAAGAAGCTACTGGACCTCGTTCAGCAGTCATGTAACTATAAGCAGCTTCGGAAAGGAGCCAATGAGGCCACCAAAACCCTCAACAGGGG
CATCTCTGAGTTCATCGTGATGGCTGCAGACGCCGAGCCACTGGAGATCATTCTGCACCTGCCGCTGCTGTGTGAAGACAAGAATGTGCC
CTACGTGTTTGTGCGCTCCAAGCAGGCCCTGGGGAGAGCCTGTGGGGTCTCCAGGCCTGTCATCGCCTGTTCTGTCACCATCAAAGAAGG
CTCGCAGCTGAAACAGCAGATCCAATCCATTCAGCAGTCCATTGAAAGGCTCTTAGTCTAAACCTGTGGCCTCTGCCACGTGCTCCCTGC
CAGCTTCCCCCCTGAGGTTGTGTATCATATTATCTGTGTTAGCATGTAGTATTTTCAGCTACTCTCTATTGTTATAAAATGTAGTACTAA
ATCTGGTTTCTGGATTTTTGTGTTGTTTTTGTTCTGTTTTACAGGGTTGCTATCCCCCTTCCTTTCCTCCCTCCCTCTGCCATCCTTCAT
CCTTTTATCCTCCCTTTTTGGAACAAGTGTTCAGAGCAGACAGAAGCAGGGTGGTGGCACCGTTGAAAGGCAGAAAGAGCCAGGAGAAAG
CTGATGGAGCCAGGACAGAGATCTGGTTCCAGCTTTCAGCCACTAGCTTCCTGTTGTGTGCGGGGTGTGGTGGAATTAAACAGCATTCAT
TGTGTGTCCCTGTGCCTGGCACACAGAATCATTCATACGTGTTCAAGTGATCAAGGGGTTTCATTTGCTCTTGGGGGATTAGGTATCATT
TGGGGAGGAAGCATGTGTTCTGTGAGGTTGTTCGGCTATGTCCAAGTGTCGTTTACTAATGTACCCCTGCTGTTTGCTTTTGGTAATGTG
ATGTTGATGTTCTCCCCCTACCCACAACCATGCCCTTGAGGGTAGCAGGGCAGCAGCATACCAAAGAGATGTGCTGCAGGACTCCGGAGG
CAGCCTGGGTGGGTGAGCCATGGGGCAGTTGACCTGGGTCTTGAAAGAGTCGGGAGTGACAAGCTCAGAGAGCATGAACTGATGCTGGCA
TGAAGGATTCCAGGAAGATCATGGAGACCTGGCTGGTAGCTGTAACAGAGATGGTGGAGTCCAAGGAAACAGCCTGTCTCTGGTGAATGG
GACTTTCTTTGGTGGACACTTGGCACCAGCTCTGAGAGCCCTTCCCCTGTGTCCTGCCACCATGTGGGTCAGATGTACTCTCTGTCACAT

>4500_4500_10_ANKLE2-NHP2L1_ANKLE2_chr12_133324418_ENST00000337516_NHP2L1_chr22_42076368_ENST00000215956_length(amino acids)=537AA_BP=410
MLWPRLAAAEWAALAWELLGASVLLIAVRWLVRRLGPRPGGLGRSGTPVPPPSAAAAPASGEMTMDALLARLKLLNPDDLREEIVKAGLK
CGPITSTTRFIFEKKLAQALLEQGGRLSSFYHHEAGVTALSQDPQRILKPAEGNPTDQAGFSEDRDFGYSVGLNPPEEEAVTSKTCSVPP
SDTDTYRAGATASKEPPLYYGVCPVYEDVPARNERIYVYENKKEALQAVKMIKGSRFKAFSTREDAEKFARGICDYFPSPSKTSLPLSPV
KTAPLFSNDRLKDGLCLSESETVNKERANSYKNPRTQDLTAKLRKAVEKGEEDTFSDLIWSNPRYLIGSGDNPTIVQEGCRYNVMHVAAK
ENQASICQLTLDVLENPDFMRLMYPDDDEAMLQKRIRYVVDLYLNTPDKMTEADVNPKAYPLADAHLTKKLLDLVQQSCNYKQLRKGANE

--------------------------------------------------------------
>4500_4500_11_ANKLE2-NHP2L1_ANKLE2_chr12_133324418_ENST00000337516_NHP2L1_chr22_42076368_ENST00000355257_length(transcript)=2684nt_BP=1297nt
GCGGGGTCCTGGGACGGGCGCGGCGCGGGGCGCGGGCTTCTCGGCGGCTGCGGCCCGGGCGGCGGCGATGCTGTGGCCGCGGCTGGCGGC
GGCCGAGTGGGCGGCGCTGGCCTGGGAGCTGCTGGGCGCCTCGGTGCTGCTGATCGCTGTGCGGTGGCTGGTGCGGCGGCTGGGCCCGCG
GCCGGGAGGTCTGGGCCGCAGCGGGACCCCAGTTCCTCCGCCAAGCGCGGCCGCCGCCCCCGCCTCAGGTGAAATGACAATGGATGCTCT
GTTGGCTCGATTGAAACTTCTGAATCCAGATGACCTTAGAGAAGAAATCGTCAAAGCCGGATTGAAATGTGGACCCATTACATCAACTAC
AAGGTTCATTTTTGAGAAAAAATTGGCTCAGGCTTTACTGGAGCAAGGAGGAAGGCTGTCTTCTTTCTACCACCATGAGGCAGGTGTCAC
AGCTCTCAGCCAGGACCCACAAAGGATTTTGAAGCCAGCTGAAGGGAACCCAACTGATCAGGCTGGTTTTTCTGAAGACAGAGATTTTGG
TTACAGTGTGGGCCTGAATCCTCCAGAGGAGGAAGCTGTGACATCCAAGACCTGCTCGGTGCCCCCTAGTGACACCGACACCTACAGAGC
TGGAGCGACTGCGTCTAAGGAGCCGCCCCTGTACTATGGGGTGTGTCCAGTGTATGAGGACGTCCCAGCGAGAAATGAAAGGATCTATGT
TTATGAAAATAAAAAGGAAGCATTGCAAGCTGTCAAGATGATCAAAGGGTCCCGATTTAAAGCTTTTTCTACCAGAGAAGACGCTGAGAA
ATTTGCTAGAGGAATTTGTGATTATTTCCCTTCTCCAAGCAAAACGTCCTTACCACTGTCTCCTGTGAAAACAGCTCCACTCTTTAGCAA
TGACAGGTTGAAAGATGGTTTGTGCTTGTCGGAATCAGAAACAGTCAACAAAGAGCGAGCGAACAGTTACAAAAATCCCCGCACGCAGGA
CCTCACCGCCAAGCTTCGGAAAGCTGTGGAGAAGGGAGAGGAGGACACCTTTTCTGACCTTATCTGGAGCAACCCCCGGTATCTGATAGG
CTCAGGAGACAACCCCACTATCGTGCAGGAAGGGTGCAGGTACAACGTGATGCATGTTGCTGCCAAAGAGAACCAGGCTTCCATCTGCCA
GCTGACTCTGGACGTCCTGGAGAACCCTGACTTCATGAGGCTGATGTACCCTGATGACGACGAGGCCATGCTGCAGAAGCGTATCCGTTA
CGTGGTGGACCTGTACCTCAACACCCCCGACAAGATGACTGAGGCTGATGTGAATCCAAAGGCCTATCCCCTTGCCGATGCCCACCTCAC
CAAGAAGCTACTGGACCTCGTTCAGCAGTCATGTAACTATAAGCAGCTTCGGAAAGGAGCCAATGAGGCCACCAAAACCCTCAACAGGGG
CATCTCTGAGTTCATCGTGATGGCTGCAGACGCCGAGCCACTGGAGATCATTCTGCACCTGCCGCTGCTGTGTGAAGACAAGAATGTGCC
CTACGTGTTTGTGCGCTCCAAGCAGGCCCTGGGGAGAGCCTGTGGGGTCTCCAGGCCTGTCATCGCCTGTTCTGTCACCATCAAAGAAGG
CTCGCAGCTGAAACAGCAGATCCAATCCATTCAGCAGTCCATTGAAAGGCTCTTAGTCTAAACCTGTGGCCTCTGCCACGTGCTCCCTGC
CAGCTTCCCCCCTGAGGTTGTGTATCATATTATCTGTGTTAGCATGTAGTATTTTCAGCTACTCTCTATTGTTATAAAATGTAGTACTAA
ATCTGGTTTCTGGATTTTTGTGTTGTTTTTGTTCTGTTTTACAGGGTTGCTATCCCCCTTCCTTTCCTCCCTCCCTCTGCCATCCTTCAT
CCTTTTATCCTCCCTTTTTGGAACAAGTGTTCAGAGCAGACAGAAGCAGGGTGGTGGCACCGTTGAAAGGCAGAAAGAGCCAGGAGAAAG
CTGATGGAGCCAGGACAGAGATCTGGTTCCAGCTTTCAGCCACTAGCTTCCTGTTGTGTGCGGGGTGTGGTGGAATTAAACAGCATTCAT
TGTGTGTCCCTGTGCCTGGCACACAGAATCATTCATACGTGTTCAAGTGATCAAGGGGTTTCATTTGCTCTTGGGGGATTAGGTATCATT
TGGGGAGGAAGCATGTGTTCTGTGAGGTTGTTCGGCTATGTCCAAGTGTCGTTTACTAATGTACCCCTGCTGTTTGCTTTTGGTAATGTG
ATGTTGATGTTCTCCCCCTACCCACAACCATGCCCTTGAGGGTAGCAGGGCAGCAGCATACCAAAGAGATGTGCTGCAGGACTCCGGAGG
CAGCCTGGGTGGGTGAGCCATGGGGCAGTTGACCTGGGTCTTGAAAGAGTCGGGAGTGACAAGCTCAGAGAGCATGAACTGATGCTGGCA
TGAAGGATTCCAGGAAGATCATGGAGACCTGGCTGGTAGCTGTAACAGAGATGGTGGAGTCCAAGGAAACAGCCTGTCTCTGGTGAATGG
GACTTTCTTTGGTGGACACTTGGCACCAGCTCTGAGAGCCCTTCCCCTGTGTCCTGCCACCATGTGGGTCAGATGTACTCTCTGTCACAT

>4500_4500_11_ANKLE2-NHP2L1_ANKLE2_chr12_133324418_ENST00000337516_NHP2L1_chr22_42076368_ENST00000355257_length(amino acids)=537AA_BP=410
MLWPRLAAAEWAALAWELLGASVLLIAVRWLVRRLGPRPGGLGRSGTPVPPPSAAAAPASGEMTMDALLARLKLLNPDDLREEIVKAGLK
CGPITSTTRFIFEKKLAQALLEQGGRLSSFYHHEAGVTALSQDPQRILKPAEGNPTDQAGFSEDRDFGYSVGLNPPEEEAVTSKTCSVPP
SDTDTYRAGATASKEPPLYYGVCPVYEDVPARNERIYVYENKKEALQAVKMIKGSRFKAFSTREDAEKFARGICDYFPSPSKTSLPLSPV
KTAPLFSNDRLKDGLCLSESETVNKERANSYKNPRTQDLTAKLRKAVEKGEEDTFSDLIWSNPRYLIGSGDNPTIVQEGCRYNVMHVAAK
ENQASICQLTLDVLENPDFMRLMYPDDDEAMLQKRIRYVVDLYLNTPDKMTEADVNPKAYPLADAHLTKKLLDLVQQSCNYKQLRKGANE

--------------------------------------------------------------
>4500_4500_12_ANKLE2-NHP2L1_ANKLE2_chr12_133324418_ENST00000337516_NHP2L1_chr22_42076368_ENST00000401959_length(transcript)=2647nt_BP=1297nt
GCGGGGTCCTGGGACGGGCGCGGCGCGGGGCGCGGGCTTCTCGGCGGCTGCGGCCCGGGCGGCGGCGATGCTGTGGCCGCGGCTGGCGGC
GGCCGAGTGGGCGGCGCTGGCCTGGGAGCTGCTGGGCGCCTCGGTGCTGCTGATCGCTGTGCGGTGGCTGGTGCGGCGGCTGGGCCCGCG
GCCGGGAGGTCTGGGCCGCAGCGGGACCCCAGTTCCTCCGCCAAGCGCGGCCGCCGCCCCCGCCTCAGGTGAAATGACAATGGATGCTCT
GTTGGCTCGATTGAAACTTCTGAATCCAGATGACCTTAGAGAAGAAATCGTCAAAGCCGGATTGAAATGTGGACCCATTACATCAACTAC
AAGGTTCATTTTTGAGAAAAAATTGGCTCAGGCTTTACTGGAGCAAGGAGGAAGGCTGTCTTCTTTCTACCACCATGAGGCAGGTGTCAC
AGCTCTCAGCCAGGACCCACAAAGGATTTTGAAGCCAGCTGAAGGGAACCCAACTGATCAGGCTGGTTTTTCTGAAGACAGAGATTTTGG
TTACAGTGTGGGCCTGAATCCTCCAGAGGAGGAAGCTGTGACATCCAAGACCTGCTCGGTGCCCCCTAGTGACACCGACACCTACAGAGC
TGGAGCGACTGCGTCTAAGGAGCCGCCCCTGTACTATGGGGTGTGTCCAGTGTATGAGGACGTCCCAGCGAGAAATGAAAGGATCTATGT
TTATGAAAATAAAAAGGAAGCATTGCAAGCTGTCAAGATGATCAAAGGGTCCCGATTTAAAGCTTTTTCTACCAGAGAAGACGCTGAGAA
ATTTGCTAGAGGAATTTGTGATTATTTCCCTTCTCCAAGCAAAACGTCCTTACCACTGTCTCCTGTGAAAACAGCTCCACTCTTTAGCAA
TGACAGGTTGAAAGATGGTTTGTGCTTGTCGGAATCAGAAACAGTCAACAAAGAGCGAGCGAACAGTTACAAAAATCCCCGCACGCAGGA
CCTCACCGCCAAGCTTCGGAAAGCTGTGGAGAAGGGAGAGGAGGACACCTTTTCTGACCTTATCTGGAGCAACCCCCGGTATCTGATAGG
CTCAGGAGACAACCCCACTATCGTGCAGGAAGGGTGCAGGTACAACGTGATGCATGTTGCTGCCAAAGAGAACCAGGCTTCCATCTGCCA
GCTGACTCTGGACGTCCTGGAGAACCCTGACTTCATGAGGCTGATGTACCCTGATGACGACGAGGCCATGCTGCAGAAGCGTATCCGTTA
CGTGGTGGACCTGTACCTCAACACCCCCGACAAGATGACTGAGGCTGATGTGAATCCAAAGGCCTATCCCCTTGCCGATGCCCACCTCAC
CAAGAAGCTACTGGACCTCGTTCAGCAGTCATGTAACTATAAGCAGCTTCGGAAAGGAGCCAATGAGGCCACCAAAACCCTCAACAGGGG
CATCTCTGAGTTCATCGTGATGGCTGCAGACGCCGAGCCACTGGAGATCATTCTGCACCTGCCGCTGCTGTGTGAAGACAAGAATGTGCC
CTACGTGTTTGTGCGCTCCAAGCAGGCCCTGGGGAGAGCCTGTGGGGTCTCCAGGCCTGTCATCGCCTGTTCTGTCACCATCAAAGAAGG
CTCGCAGCTGAAACAGCAGATCCAATCCATTCAGCAGTCCATTGAAAGGCTCTTAGTCTAAACCTGTGGCCTCTGCCACGTGCTCCCTGC
CAGCTTCCCCCCTGAGGTTGTGTATCATATTATCTGTGTTAGCATGTAGTATTTTCAGCTACTCTCTATTGTTATAAAATGTAGTACTAA
ATCTGGTTTCTGGATTTTTGTGTTGTTTTTGTTCTGTTTTACAGGGTTGCTATCCCCCTTCCTTTCCTCCCTCCCTCTGCCATCCTTCAT
CCTTTTATCCTCCCTTTTTGGAACAAGTGTTCAGAGCAGACAGAAGCAGGGTGGTGGCACCGTTGAAAGGCAGAAAGAGCCAGGAGAAAG
CTGATGGAGCCAGGACAGAGATCTGGTTCCAGCTTTCAGCCACTAGCTTCCTGTTGTGTGCGGGGTGTGGTGGAATTAAACAGCATTCAT
TGTGTGTCCCTGTGCCTGGCACACAGAATCATTCATACGTGTTCAAGTGATCAAGGGGTTTCATTTGCTCTTGGGGGATTAGGTATCATT
TGGGGAGGAAGCATGTGTTCTGTGAGGTTGTTCGGCTATGTCCAAGTGTCGTTTACTAATGTACCCCTGCTGTTTGCTTTTGGTAATGTG
ATGTTGATGTTCTCCCCCTACCCACAACCATGCCCTTGAGGGTAGCAGGGCAGCAGCATACCAAAGAGATGTGCTGCAGGACTCCGGAGG
CAGCCTGGGTGGGTGAGCCATGGGGCAGTTGACCTGGGTCTTGAAAGAGTCGGGAGTGACAAGCTCAGAGAGCATGAACTGATGCTGGCA
TGAAGGATTCCAGGAAGATCATGGAGACCTGGCTGGTAGCTGTAACAGAGATGGTGGAGTCCAAGGAAACAGCCTGTCTCTGGTGAATGG
GACTTTCTTTGGTGGACACTTGGCACCAGCTCTGAGAGCCCTTCCCCTGTGTCCTGCCACCATGTGGGTCAGATGTACTCTCTGTCACAT

>4500_4500_12_ANKLE2-NHP2L1_ANKLE2_chr12_133324418_ENST00000337516_NHP2L1_chr22_42076368_ENST00000401959_length(amino acids)=537AA_BP=410
MLWPRLAAAEWAALAWELLGASVLLIAVRWLVRRLGPRPGGLGRSGTPVPPPSAAAAPASGEMTMDALLARLKLLNPDDLREEIVKAGLK
CGPITSTTRFIFEKKLAQALLEQGGRLSSFYHHEAGVTALSQDPQRILKPAEGNPTDQAGFSEDRDFGYSVGLNPPEEEAVTSKTCSVPP
SDTDTYRAGATASKEPPLYYGVCPVYEDVPARNERIYVYENKKEALQAVKMIKGSRFKAFSTREDAEKFARGICDYFPSPSKTSLPLSPV
KTAPLFSNDRLKDGLCLSESETVNKERANSYKNPRTQDLTAKLRKAVEKGEEDTFSDLIWSNPRYLIGSGDNPTIVQEGCRYNVMHVAAK
ENQASICQLTLDVLENPDFMRLMYPDDDEAMLQKRIRYVVDLYLNTPDKMTEADVNPKAYPLADAHLTKKLLDLVQQSCNYKQLRKGANE

--------------------------------------------------------------
>4500_4500_13_ANKLE2-NHP2L1_ANKLE2_chr12_133324418_ENST00000357997_NHP2L1_chr22_42076368_ENST00000215956_length(transcript)=2683nt_BP=1320nt
AGGCAGGGCGCGGGCAGCCCGGCGCGGGGTCCTGGGACGGGCGCGGCGCGGGGCGCGGGCTTCTCGGCGGCTGCGGCCCGGGCGGCGGCG
ATGCTGTGGCCGCGGCTGGCGGCGGCCGAGTGGGCGGCGCTGGCCTGGGAGCTGCTGGGCGCCTCGGTGCTGCTGATCGCTGTGCGGTGG
CTGGTGCGGCGGCTGGGCCCGCGGCCGGGAGGTCTGGGCCGCAGCGGGACCCCAGTTCCTCCGCCAAGCGCGGCCGCCGCCCCCGCCTCA
GGTGAAATGACAATGGATGCTCTGTTGGCTCGATTGAAACTTCTGAATCCAGATGACCTTAGAGAAGAAATCGTCAAAGCCGGATTGAAA
TGTGGACCCATTACATCAACTACAAGGTTCATTTTTGAGAAAAAATTGGCTCAGGCTTTACTGGAGCAAGGAGGAAGGCTGTCTTCTTTC
TACCACCATGAGGCAGGTGTCACAGCTCTCAGCCAGGACCCACAAAGGATTTTGAAGCCAGCTGAAGGGAACCCAACTGATCAGGCTGGT
TTTTCTGAAGACAGAGATTTTGGTTACAGTGTGGGCCTGAATCCTCCAGAGGAGGAAGCTGTGACATCCAAGACCTGCTCGGTGCCCCCT
AGTGACACCGACACCTACAGAGCTGGAGCGACTGCGTCTAAGGAGCCGCCCCTGTACTATGGGGTGTGTCCAGTGTATGAGGACGTCCCA
GCGAGAAATGAAAGGATCTATGTTTATGAAAATAAAAAGGAAGCATTGCAAGCTGTCAAGATGATCAAAGGGTCCCGATTTAAAGCTTTT
TCTACCAGAGAAGACGCTGAGAAATTTGCTAGAGGAATTTGTGATTATTTCCCTTCTCCAAGCAAAACGTCCTTACCACTGTCTCCTGTG
AAAACAGCTCCACTCTTTAGCAATGACAGGTTGAAAGATGGTTTGTGCTTGTCGGAATCAGAAACAGTCAACAAAGAGCGAGCGAACAGT
TACAAAAATCCCCGCACGCAGGACCTCACCGCCAAGCTTCGGAAAGCTGTGGAGAAGGGAGAGGAGGACACCTTTTCTGACCTTATCTGG
AGCAACCCCCGGTATCTGATAGGCTCAGGAGACAACCCCACTATCGTGCAGGAAGGGTGCAGGTACAACGTGATGCATGTTGCTGCCAAA
GAGAACCAGGCTTCCATCTGCCAGCTGACTCTGGACGTCCTGGAGAACCCTGACTTCATGAGGCTGATGTACCCTGATGACGACGAGGCC
ATGCTGCAGAAGCGTATCCGTTACGTGGTGGACCTGTACCTCAACACCCCCGACAAGATGACTGAGGCTGATGTGAATCCAAAGGCCTAT
CCCCTTGCCGATGCCCACCTCACCAAGAAGCTACTGGACCTCGTTCAGCAGTCATGTAACTATAAGCAGCTTCGGAAAGGAGCCAATGAG
GCCACCAAAACCCTCAACAGGGGCATCTCTGAGTTCATCGTGATGGCTGCAGACGCCGAGCCACTGGAGATCATTCTGCACCTGCCGCTG
CTGTGTGAAGACAAGAATGTGCCCTACGTGTTTGTGCGCTCCAAGCAGGCCCTGGGGAGAGCCTGTGGGGTCTCCAGGCCTGTCATCGCC
TGTTCTGTCACCATCAAAGAAGGCTCGCAGCTGAAACAGCAGATCCAATCCATTCAGCAGTCCATTGAAAGGCTCTTAGTCTAAACCTGT
GGCCTCTGCCACGTGCTCCCTGCCAGCTTCCCCCCTGAGGTTGTGTATCATATTATCTGTGTTAGCATGTAGTATTTTCAGCTACTCTCT
ATTGTTATAAAATGTAGTACTAAATCTGGTTTCTGGATTTTTGTGTTGTTTTTGTTCTGTTTTACAGGGTTGCTATCCCCCTTCCTTTCC
TCCCTCCCTCTGCCATCCTTCATCCTTTTATCCTCCCTTTTTGGAACAAGTGTTCAGAGCAGACAGAAGCAGGGTGGTGGCACCGTTGAA
AGGCAGAAAGAGCCAGGAGAAAGCTGATGGAGCCAGGACAGAGATCTGGTTCCAGCTTTCAGCCACTAGCTTCCTGTTGTGTGCGGGGTG
TGGTGGAATTAAACAGCATTCATTGTGTGTCCCTGTGCCTGGCACACAGAATCATTCATACGTGTTCAAGTGATCAAGGGGTTTCATTTG
CTCTTGGGGGATTAGGTATCATTTGGGGAGGAAGCATGTGTTCTGTGAGGTTGTTCGGCTATGTCCAAGTGTCGTTTACTAATGTACCCC
TGCTGTTTGCTTTTGGTAATGTGATGTTGATGTTCTCCCCCTACCCACAACCATGCCCTTGAGGGTAGCAGGGCAGCAGCATACCAAAGA
GATGTGCTGCAGGACTCCGGAGGCAGCCTGGGTGGGTGAGCCATGGGGCAGTTGACCTGGGTCTTGAAAGAGTCGGGAGTGACAAGCTCA
GAGAGCATGAACTGATGCTGGCATGAAGGATTCCAGGAAGATCATGGAGACCTGGCTGGTAGCTGTAACAGAGATGGTGGAGTCCAAGGA
AACAGCCTGTCTCTGGTGAATGGGACTTTCTTTGGTGGACACTTGGCACCAGCTCTGAGAGCCCTTCCCCTGTGTCCTGCCACCATGTGG

>4500_4500_13_ANKLE2-NHP2L1_ANKLE2_chr12_133324418_ENST00000357997_NHP2L1_chr22_42076368_ENST00000215956_length(amino acids)=537AA_BP=410
MLWPRLAAAEWAALAWELLGASVLLIAVRWLVRRLGPRPGGLGRSGTPVPPPSAAAAPASGEMTMDALLARLKLLNPDDLREEIVKAGLK
CGPITSTTRFIFEKKLAQALLEQGGRLSSFYHHEAGVTALSQDPQRILKPAEGNPTDQAGFSEDRDFGYSVGLNPPEEEAVTSKTCSVPP
SDTDTYRAGATASKEPPLYYGVCPVYEDVPARNERIYVYENKKEALQAVKMIKGSRFKAFSTREDAEKFARGICDYFPSPSKTSLPLSPV
KTAPLFSNDRLKDGLCLSESETVNKERANSYKNPRTQDLTAKLRKAVEKGEEDTFSDLIWSNPRYLIGSGDNPTIVQEGCRYNVMHVAAK
ENQASICQLTLDVLENPDFMRLMYPDDDEAMLQKRIRYVVDLYLNTPDKMTEADVNPKAYPLADAHLTKKLLDLVQQSCNYKQLRKGANE

--------------------------------------------------------------
>4500_4500_14_ANKLE2-NHP2L1_ANKLE2_chr12_133324418_ENST00000357997_NHP2L1_chr22_42076368_ENST00000355257_length(transcript)=2707nt_BP=1320nt
AGGCAGGGCGCGGGCAGCCCGGCGCGGGGTCCTGGGACGGGCGCGGCGCGGGGCGCGGGCTTCTCGGCGGCTGCGGCCCGGGCGGCGGCG
ATGCTGTGGCCGCGGCTGGCGGCGGCCGAGTGGGCGGCGCTGGCCTGGGAGCTGCTGGGCGCCTCGGTGCTGCTGATCGCTGTGCGGTGG
CTGGTGCGGCGGCTGGGCCCGCGGCCGGGAGGTCTGGGCCGCAGCGGGACCCCAGTTCCTCCGCCAAGCGCGGCCGCCGCCCCCGCCTCA
GGTGAAATGACAATGGATGCTCTGTTGGCTCGATTGAAACTTCTGAATCCAGATGACCTTAGAGAAGAAATCGTCAAAGCCGGATTGAAA
TGTGGACCCATTACATCAACTACAAGGTTCATTTTTGAGAAAAAATTGGCTCAGGCTTTACTGGAGCAAGGAGGAAGGCTGTCTTCTTTC
TACCACCATGAGGCAGGTGTCACAGCTCTCAGCCAGGACCCACAAAGGATTTTGAAGCCAGCTGAAGGGAACCCAACTGATCAGGCTGGT
TTTTCTGAAGACAGAGATTTTGGTTACAGTGTGGGCCTGAATCCTCCAGAGGAGGAAGCTGTGACATCCAAGACCTGCTCGGTGCCCCCT
AGTGACACCGACACCTACAGAGCTGGAGCGACTGCGTCTAAGGAGCCGCCCCTGTACTATGGGGTGTGTCCAGTGTATGAGGACGTCCCA
GCGAGAAATGAAAGGATCTATGTTTATGAAAATAAAAAGGAAGCATTGCAAGCTGTCAAGATGATCAAAGGGTCCCGATTTAAAGCTTTT
TCTACCAGAGAAGACGCTGAGAAATTTGCTAGAGGAATTTGTGATTATTTCCCTTCTCCAAGCAAAACGTCCTTACCACTGTCTCCTGTG
AAAACAGCTCCACTCTTTAGCAATGACAGGTTGAAAGATGGTTTGTGCTTGTCGGAATCAGAAACAGTCAACAAAGAGCGAGCGAACAGT
TACAAAAATCCCCGCACGCAGGACCTCACCGCCAAGCTTCGGAAAGCTGTGGAGAAGGGAGAGGAGGACACCTTTTCTGACCTTATCTGG
AGCAACCCCCGGTATCTGATAGGCTCAGGAGACAACCCCACTATCGTGCAGGAAGGGTGCAGGTACAACGTGATGCATGTTGCTGCCAAA
GAGAACCAGGCTTCCATCTGCCAGCTGACTCTGGACGTCCTGGAGAACCCTGACTTCATGAGGCTGATGTACCCTGATGACGACGAGGCC
ATGCTGCAGAAGCGTATCCGTTACGTGGTGGACCTGTACCTCAACACCCCCGACAAGATGACTGAGGCTGATGTGAATCCAAAGGCCTAT
CCCCTTGCCGATGCCCACCTCACCAAGAAGCTACTGGACCTCGTTCAGCAGTCATGTAACTATAAGCAGCTTCGGAAAGGAGCCAATGAG
GCCACCAAAACCCTCAACAGGGGCATCTCTGAGTTCATCGTGATGGCTGCAGACGCCGAGCCACTGGAGATCATTCTGCACCTGCCGCTG
CTGTGTGAAGACAAGAATGTGCCCTACGTGTTTGTGCGCTCCAAGCAGGCCCTGGGGAGAGCCTGTGGGGTCTCCAGGCCTGTCATCGCC
TGTTCTGTCACCATCAAAGAAGGCTCGCAGCTGAAACAGCAGATCCAATCCATTCAGCAGTCCATTGAAAGGCTCTTAGTCTAAACCTGT
GGCCTCTGCCACGTGCTCCCTGCCAGCTTCCCCCCTGAGGTTGTGTATCATATTATCTGTGTTAGCATGTAGTATTTTCAGCTACTCTCT
ATTGTTATAAAATGTAGTACTAAATCTGGTTTCTGGATTTTTGTGTTGTTTTTGTTCTGTTTTACAGGGTTGCTATCCCCCTTCCTTTCC
TCCCTCCCTCTGCCATCCTTCATCCTTTTATCCTCCCTTTTTGGAACAAGTGTTCAGAGCAGACAGAAGCAGGGTGGTGGCACCGTTGAA
AGGCAGAAAGAGCCAGGAGAAAGCTGATGGAGCCAGGACAGAGATCTGGTTCCAGCTTTCAGCCACTAGCTTCCTGTTGTGTGCGGGGTG
TGGTGGAATTAAACAGCATTCATTGTGTGTCCCTGTGCCTGGCACACAGAATCATTCATACGTGTTCAAGTGATCAAGGGGTTTCATTTG
CTCTTGGGGGATTAGGTATCATTTGGGGAGGAAGCATGTGTTCTGTGAGGTTGTTCGGCTATGTCCAAGTGTCGTTTACTAATGTACCCC
TGCTGTTTGCTTTTGGTAATGTGATGTTGATGTTCTCCCCCTACCCACAACCATGCCCTTGAGGGTAGCAGGGCAGCAGCATACCAAAGA
GATGTGCTGCAGGACTCCGGAGGCAGCCTGGGTGGGTGAGCCATGGGGCAGTTGACCTGGGTCTTGAAAGAGTCGGGAGTGACAAGCTCA
GAGAGCATGAACTGATGCTGGCATGAAGGATTCCAGGAAGATCATGGAGACCTGGCTGGTAGCTGTAACAGAGATGGTGGAGTCCAAGGA
AACAGCCTGTCTCTGGTGAATGGGACTTTCTTTGGTGGACACTTGGCACCAGCTCTGAGAGCCCTTCCCCTGTGTCCTGCCACCATGTGG
GTCAGATGTACTCTCTGTCACATGAGGAGAGTGCTAGTTCATGTGTTCTCCATTCTTGTGAGCATCCTAATAAATCTGTTCCATTTTGAT

>4500_4500_14_ANKLE2-NHP2L1_ANKLE2_chr12_133324418_ENST00000357997_NHP2L1_chr22_42076368_ENST00000355257_length(amino acids)=537AA_BP=410
MLWPRLAAAEWAALAWELLGASVLLIAVRWLVRRLGPRPGGLGRSGTPVPPPSAAAAPASGEMTMDALLARLKLLNPDDLREEIVKAGLK
CGPITSTTRFIFEKKLAQALLEQGGRLSSFYHHEAGVTALSQDPQRILKPAEGNPTDQAGFSEDRDFGYSVGLNPPEEEAVTSKTCSVPP
SDTDTYRAGATASKEPPLYYGVCPVYEDVPARNERIYVYENKKEALQAVKMIKGSRFKAFSTREDAEKFARGICDYFPSPSKTSLPLSPV
KTAPLFSNDRLKDGLCLSESETVNKERANSYKNPRTQDLTAKLRKAVEKGEEDTFSDLIWSNPRYLIGSGDNPTIVQEGCRYNVMHVAAK
ENQASICQLTLDVLENPDFMRLMYPDDDEAMLQKRIRYVVDLYLNTPDKMTEADVNPKAYPLADAHLTKKLLDLVQQSCNYKQLRKGANE

--------------------------------------------------------------
>4500_4500_15_ANKLE2-NHP2L1_ANKLE2_chr12_133324418_ENST00000357997_NHP2L1_chr22_42076368_ENST00000401959_length(transcript)=2670nt_BP=1320nt
AGGCAGGGCGCGGGCAGCCCGGCGCGGGGTCCTGGGACGGGCGCGGCGCGGGGCGCGGGCTTCTCGGCGGCTGCGGCCCGGGCGGCGGCG
ATGCTGTGGCCGCGGCTGGCGGCGGCCGAGTGGGCGGCGCTGGCCTGGGAGCTGCTGGGCGCCTCGGTGCTGCTGATCGCTGTGCGGTGG
CTGGTGCGGCGGCTGGGCCCGCGGCCGGGAGGTCTGGGCCGCAGCGGGACCCCAGTTCCTCCGCCAAGCGCGGCCGCCGCCCCCGCCTCA
GGTGAAATGACAATGGATGCTCTGTTGGCTCGATTGAAACTTCTGAATCCAGATGACCTTAGAGAAGAAATCGTCAAAGCCGGATTGAAA
TGTGGACCCATTACATCAACTACAAGGTTCATTTTTGAGAAAAAATTGGCTCAGGCTTTACTGGAGCAAGGAGGAAGGCTGTCTTCTTTC
TACCACCATGAGGCAGGTGTCACAGCTCTCAGCCAGGACCCACAAAGGATTTTGAAGCCAGCTGAAGGGAACCCAACTGATCAGGCTGGT
TTTTCTGAAGACAGAGATTTTGGTTACAGTGTGGGCCTGAATCCTCCAGAGGAGGAAGCTGTGACATCCAAGACCTGCTCGGTGCCCCCT
AGTGACACCGACACCTACAGAGCTGGAGCGACTGCGTCTAAGGAGCCGCCCCTGTACTATGGGGTGTGTCCAGTGTATGAGGACGTCCCA
GCGAGAAATGAAAGGATCTATGTTTATGAAAATAAAAAGGAAGCATTGCAAGCTGTCAAGATGATCAAAGGGTCCCGATTTAAAGCTTTT
TCTACCAGAGAAGACGCTGAGAAATTTGCTAGAGGAATTTGTGATTATTTCCCTTCTCCAAGCAAAACGTCCTTACCACTGTCTCCTGTG
AAAACAGCTCCACTCTTTAGCAATGACAGGTTGAAAGATGGTTTGTGCTTGTCGGAATCAGAAACAGTCAACAAAGAGCGAGCGAACAGT
TACAAAAATCCCCGCACGCAGGACCTCACCGCCAAGCTTCGGAAAGCTGTGGAGAAGGGAGAGGAGGACACCTTTTCTGACCTTATCTGG
AGCAACCCCCGGTATCTGATAGGCTCAGGAGACAACCCCACTATCGTGCAGGAAGGGTGCAGGTACAACGTGATGCATGTTGCTGCCAAA
GAGAACCAGGCTTCCATCTGCCAGCTGACTCTGGACGTCCTGGAGAACCCTGACTTCATGAGGCTGATGTACCCTGATGACGACGAGGCC
ATGCTGCAGAAGCGTATCCGTTACGTGGTGGACCTGTACCTCAACACCCCCGACAAGATGACTGAGGCTGATGTGAATCCAAAGGCCTAT
CCCCTTGCCGATGCCCACCTCACCAAGAAGCTACTGGACCTCGTTCAGCAGTCATGTAACTATAAGCAGCTTCGGAAAGGAGCCAATGAG
GCCACCAAAACCCTCAACAGGGGCATCTCTGAGTTCATCGTGATGGCTGCAGACGCCGAGCCACTGGAGATCATTCTGCACCTGCCGCTG
CTGTGTGAAGACAAGAATGTGCCCTACGTGTTTGTGCGCTCCAAGCAGGCCCTGGGGAGAGCCTGTGGGGTCTCCAGGCCTGTCATCGCC
TGTTCTGTCACCATCAAAGAAGGCTCGCAGCTGAAACAGCAGATCCAATCCATTCAGCAGTCCATTGAAAGGCTCTTAGTCTAAACCTGT
GGCCTCTGCCACGTGCTCCCTGCCAGCTTCCCCCCTGAGGTTGTGTATCATATTATCTGTGTTAGCATGTAGTATTTTCAGCTACTCTCT
ATTGTTATAAAATGTAGTACTAAATCTGGTTTCTGGATTTTTGTGTTGTTTTTGTTCTGTTTTACAGGGTTGCTATCCCCCTTCCTTTCC
TCCCTCCCTCTGCCATCCTTCATCCTTTTATCCTCCCTTTTTGGAACAAGTGTTCAGAGCAGACAGAAGCAGGGTGGTGGCACCGTTGAA
AGGCAGAAAGAGCCAGGAGAAAGCTGATGGAGCCAGGACAGAGATCTGGTTCCAGCTTTCAGCCACTAGCTTCCTGTTGTGTGCGGGGTG
TGGTGGAATTAAACAGCATTCATTGTGTGTCCCTGTGCCTGGCACACAGAATCATTCATACGTGTTCAAGTGATCAAGGGGTTTCATTTG
CTCTTGGGGGATTAGGTATCATTTGGGGAGGAAGCATGTGTTCTGTGAGGTTGTTCGGCTATGTCCAAGTGTCGTTTACTAATGTACCCC
TGCTGTTTGCTTTTGGTAATGTGATGTTGATGTTCTCCCCCTACCCACAACCATGCCCTTGAGGGTAGCAGGGCAGCAGCATACCAAAGA
GATGTGCTGCAGGACTCCGGAGGCAGCCTGGGTGGGTGAGCCATGGGGCAGTTGACCTGGGTCTTGAAAGAGTCGGGAGTGACAAGCTCA
GAGAGCATGAACTGATGCTGGCATGAAGGATTCCAGGAAGATCATGGAGACCTGGCTGGTAGCTGTAACAGAGATGGTGGAGTCCAAGGA
AACAGCCTGTCTCTGGTGAATGGGACTTTCTTTGGTGGACACTTGGCACCAGCTCTGAGAGCCCTTCCCCTGTGTCCTGCCACCATGTGG

>4500_4500_15_ANKLE2-NHP2L1_ANKLE2_chr12_133324418_ENST00000357997_NHP2L1_chr22_42076368_ENST00000401959_length(amino acids)=537AA_BP=410
MLWPRLAAAEWAALAWELLGASVLLIAVRWLVRRLGPRPGGLGRSGTPVPPPSAAAAPASGEMTMDALLARLKLLNPDDLREEIVKAGLK
CGPITSTTRFIFEKKLAQALLEQGGRLSSFYHHEAGVTALSQDPQRILKPAEGNPTDQAGFSEDRDFGYSVGLNPPEEEAVTSKTCSVPP
SDTDTYRAGATASKEPPLYYGVCPVYEDVPARNERIYVYENKKEALQAVKMIKGSRFKAFSTREDAEKFARGICDYFPSPSKTSLPLSPV
KTAPLFSNDRLKDGLCLSESETVNKERANSYKNPRTQDLTAKLRKAVEKGEEDTFSDLIWSNPRYLIGSGDNPTIVQEGCRYNVMHVAAK
ENQASICQLTLDVLENPDFMRLMYPDDDEAMLQKRIRYVVDLYLNTPDKMTEADVNPKAYPLADAHLTKKLLDLVQQSCNYKQLRKGANE

--------------------------------------------------------------
>4500_4500_16_ANKLE2-NHP2L1_ANKLE2_chr12_133324418_ENST00000539605_NHP2L1_chr22_42076368_ENST00000215956_length(transcript)=9092nt_BP=7729nt
GCCCGGGCGGCGGCGATGCTGTGGCCGCGGCTGGCGGCGGCCGAGTGGGCGGCGCTGGCCTGGGAGCTGCTGGGCGCCTCGGTGCTGCTG
ATCGCTGTGCGGTGGCTGGTGCGGCGGCTGGGCCCGCGGCCGGGAGGTCTGGGCCGCAGCGGGACCCCAGTTCCTCCGCCAAGCGCGGCC
GCCGCCCCCGCCTCAGGTAAGGCCCAGGCGGTCGCTGGGTCCCCGCACCCTGGCCCCTTCCCCGCCCCGACGCCCTCCTCGGGCCTGGGG
TCCCGGCCGCGCCCCTGGAGCCGGCAGCAGTTGGGCGAGGCGGCCGGGGAAACCAGGGCCGGTCGGGAAAGGCCATTCCGGCCGCGGAAA
GGGCAGTTGCGGGGACTTGGCTTCCCGGGCCGGGGGCGGAGGGGCCACGCCGGGTTCGGGGGTGAGAGCTTTCCCGGGCCCTGGAGCAGC
CTCCGGGGAAGGCGGCGGGGGCCCGGCGAGGCGTTAGCGGAGACTCTTGCTGCGGTCTCTCGAGACCTGGGGAGGGATGGCCCAAAGGAG
GGCGGCGCGGGGAGGAAACCCCTGGGTCCCGGATGTGTTTGGAACGTGAAGCCATTGCGGTTACTGGTCATGGAACATAAGGCAGAGACG
GAAAAGGCAAATGTAACTCAGGGGTTTGGGGCCAGAGGAAGAGGGAGAAGGTGGCCATTTATTGCTTTGCGGTAGACTGTCGGGTCTGGG
TGATGTGGAGATCAGAGGTGGGTTTTGGTCGTTTTAAGTTTGAGGTAACTGATACAGTGAACTGTGTATTTCAGCTCCATCCCCTTTTCC
TGGCATACAACTCTTGAAATCCCGGGAACCTCCAAAGTGATGTCTTTTGTAGGCTGAGTGGACTGGTGGCCGGCAGCCCCTAGGGAGCTT
CTGGATGGGGCTGGTCGCAGGAAAGACCAAGGCAGGGTTAGAGGTTCTGGGGACTTTCAGCCCCACCCCCAACCTCTGGGGAGGAGAGAG
GGGTGAAGGTTGCGTTGATCACCAGTGGCTGATGAATCACGCCTGTGAAATGAAGTTCCTGTAAAAACCCAAAAGGGCTGGGTTCAGGGA
GCTTCCAGATAGTACGTGGGGGTTCCTGGAGGCGGTGCCCAGAGAGGCCCTGAATTTCCAAGCGCTTCCCCCCGGTTTTACGTCACGCAT
CTCTTCACCTGTATTCTTTGTAATCCTTTATACTCTGCTGGTAAGTGTAAGTAAAACATGTCTGTGAGTTCGGGAGCCACTCTAGCAAAT
TACCGCAACCTGAGGAGGTCACCGGGTTACGCCCCGTCGGTCCCAAGCGCAGGTCAAACAACCTGGGCACTGGAAGTGGGGGGCAGTCTT
GCGGGGCTGAGCCGTTAACCTGTGGGGGTCTGCTGGTATCTCCAGGAAGACGCTGTCAGAATAGATGACTGAATTAGGATGACAGACGAC
ACCCAGCCTGTGTCCACTGCAGAACTGACGACCTGCGTGATTTGTGGGGAGAAAATCCCCACATACCTGGTGTCCGAAGCATGTTGCAAG
ACTAGTGGGAGAAACTGAGTTTGTTTTTACTCTAAATTGTCAGACTGTTAGTCACTGCGGAGAGGTGCTTTCTGATGATTGAGTGGGGAT
TCCTGTCCAATTGTGTGAGTTTGTGTCTCGGCCCTACCACTTTTTTTTTTTTTTTTTTTTGAAATGTAGTCTCGCCCTGTGGCCCAGGCT
GGAGTGCAGTGGCGCGATCTCGGCTCACTGCAAGCTCCGCCTCCCGGGTTCAAGCGATTCTCCTGCATCAGCCTCCCGAGTAGCTGGGAT
TACAGGCGCCTGCCACCACGCCCGGCTAATTTTTGTATTTTTAATAGAGACGGGGTTTCACCATGTTGGCCAGGATGGTCTCGAATTCCT
GACCTCAGGTGATCCACCTGCCTCAGCTTCCCAAAATGCTGGGATTACAGGTGTGAGCCATCGCACCGGGCCCTACCACTTATTGCTGTG
GGCTTAACCTGTTTTCAGCCTGCTCTTTTAGGAATGGGGATGATAGTGATACCTGGTTAGGCTTTTTTGGGAGTTGGGTAAGTGCAGCAC
TTGGTATGTGTTAAGCACCTCTGAGTGCTGTTACTGTCACCAGCGGCATCATCCAGGCAGAGCTGCGGACAAGGTGGCGGCGGGTGAGGG
TGGTGTTTTGAGAATGGCTGAAATAAAAAAATACTGATTTATTTTATATAAAAATATGTTTTTATATATGATGTATAATATACGTATATC
ATGGCATATGATACGTGTATATCATATAGCACATATAGTATACATATATATAGTCAGCAGAGATTTAGAGAAACTGGGCCTCGTGCATTG
CAGGTGGGGACGGTAAGTGGTGCAGCTACTCTGGGAATCAGCCTGGCAGGTTTTTAGGAAGTTAAACCTGCCCTGCATTCCTGAGCTTTT
ATTAGACAAATGAAAACTATTTTCACACAAAAACCCATATTTAATGTTCATAGCAACTTTATTTGTAATTACCAGAAACTGAAATAACTC
AAATGGTTAAACTTGCACACTGATACCCCGGGGTGCCACTCCGCAGCGATCCTCTCTGCCACGTGGGTGCCCCGGGGTGCCACTCTGCAT
GATCCACTCTGCCACGTGGGTGCCCCGGGGTGCCACTCCGCAGCGATCCTCTCTGCCACGTGGGTGCCCCGGGGTGCCACTCTGCGTGAT
CCACTCTGCCACGTGGGTGCCCCGGGGTGCCACTCCGCAGCGATCCTCTCTGCCACGTGGGTGCCCCGGGGTGCCACTCCGCAGCGATCC
ACTCTGCCACGTGGGTGCCCCGGGGTGCCACTCCGCAGCGATCCTCTCTGCCACGTGGGTGCCCCGGGGTGCCACACTGCGTGATCCACT
CTGCCACGTGGGTGCCCCGGGGTGCCACTCCGCAGCGATCCACTCTGCCACGTGGGTGGATCTCAAGGGCATTATGCTGAATAGGAAAAG
CCAGTCTCAAAAGTTGTGTACTTGGCCGGTTGCGGTGGCTCATGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGCAGGTGGATCACAAG
GTCAGGAGTTCAAGATCAGCCTGGCCAACATGGTGAGGCAGTCTCCACTAAAAATACAAAAAAATAGCGGGGCGTGGTGGCAGGTACCTG
TAATCCCAGCTACTCGGGAGGCTGAGGCAGCAGAATTGCTTGAACCCAGGAGGTGGAGGTTGCGGTGAGCAGAGATCGTGCCACTGCACT
CCAGCCTGGGCGACAGAGCAAGACTCCATCTCAAAAAAAAAAAAATTGTTAATGGAACATTATAACCCAGTGTTCAGACCTAGCTGTTTC
TCACATCTTTACCCATCGATCTGTCAAAGACCTTGTGATCATACTGATACTTCCAATTTCAATGCGACGTCCGCGGGTTTATTCTTTTTT
TTTTAGGTGGAGTCTCACTCTGTTGTCCAGGCTGGAGACTCACTGCAACCTCTGCCTGCCCAGTTCAAGCGATTCTCCCACCTAGCCTGC
TGAGTAGCTGGGATGACAGGTGCATGCCACCATGCCTGGCTAATTTTTGTGTTTTTAGTAGACACCTGGTTTCATCATGTTGGCCAGGCT
GGTCTCAAACACCTGACCTCAAATGATCCATGCACCTTGGCCTCCCAAAGTGCTGGGATTACCAGCATGAGCCACCGTGTCCGGCTCCCT
GGCTTTATTCTAATGCAAGAGTCAGTAAACTGTGGTCCAAACTGGCCCCCACCTATTTTCCTTAGTAAAGTTTTATTGGAATACAACCAT
ACCCTTTTGTTTATGTATATCTGTGGCTGTTCTTTTTTTTTTTTTTTTTGGAGACGGGGTCTTGCTCTGTTGCCCAGGTTGGAGTGCAGT
GGCACAAACAGGGCTCACTGCATCCTCAAACTCTTAGGCTTAATTTATCCTCCTTCCTCAGCCCCCCAAGTAGTTGGAACCACAGGTGCA
CGTCACCACACTCAGCTAATTTTTTTTTTTTGAGACGGAGTCTCGCTCTGTCGCCCAGGCTGGAGTGCAGTGCCGCCATCTCTGCTCACT
GCAAGTTCTGCCCCCTGGGTTCACACCATTCTCCTGCCTCAGCCTCCTGAGTAGCTGGGACTACAGGCGCCCGCCACCATGGCCGGCTAA
TTTTTTAGTATTTTTAGTAGAGACAGGGTTTCACCGTGTTTGCCAGGATAGTCTCAATCTCCTGACCTCATGATCCACCTGCCTCGGCCT
CCCAAAGTGCTGGGATTACAGGCATGAGTCACCGCGCCCAGCCATCAGATAATTTTTAAAGTTTTTGTAGAAAGGGTGTCGCTGTGTTAC
CCAGGCTGGTCTTGAACTCCTGGGCTCAAGTGATCTTCCCGCCTCGGCCTCCCCAAGCGCTGGGGTGACAGGTGTGAGCCGCCACACGCG
GCCTGTGGCTGTTCTGAGCACTCACGTGGCCTTTGGCTCATAGAGTCTGAGATGCTTACTCTCTCGCCCTTTACAGGAATCGTTTGCTGA
AACCCTGTTCTCACTCCCACTTTCCTTTCTGTCATTGAGAGTCCTGGCTCTCATCAGCCACCGTGTATTCCAATTATTTGCTTTGCCCTA
GAGTCCACAGAAAATAGCTTTAGGTGTGTTAACCTATACCATTGTGAAAACATCTACTGCCTAGAGCCTGTTCACACGGTAATGGTGCAC
AGTCCTTTTTGTCTTTCTCCTTAGAGCACCTAGTCACTCACTGTTTTCCAAAGTTACGTAGGTTAGCTTCCCCTGTGTTACTCACTTGTA
ATACAGTTAGGTGCATTTCTTCTGGCTAGTATTCCATGTGGGTGTCTCCCCCATCTTTTTGTTTATTTACTTATTTCTTTTTTTTTTGTT
TTTTTTGTTGTTGTTGTTTTATTGAGGTGGAGTCTCGCTCTGTTGCCCAGGCTGGAGTGTAGTGGTGCGATCTCGGCTCACTGTGACCTC
TGCCTCCTGGGTTCCAGCGAGTCTCCTGCCTCAGGTTCCCGAGTAGCTGGGATTACAGGTGCCCGCCACTGCGCCTGTCTAATTTTTGTA
TTTTTTTTTTAGTAGAGATGGGGTTTCACCATCTTGGCCAGGCTGGTCTCGAACTGCTGACCTCGTGATCCACCCACCTCGGTCTCCCAA
AGTGCTGCGATTACAGGCGTGAGCCACCGCACCCGGCTTTACTTATTTGAGTATGTAAATCACGAACATGTTTTTAAAAGTCAGAACCCT
GTAGAAACTTAAATTCAGATGTATTACTCCCCCCCGCCATCTTTTTTTTTGTTGTTGTTGTTGAGACAGGGTCTGATTCTGTCACCCAGG
CTGGAGTGCAGGGTTGCCATCTCAGCTCGTGGTGGCATCCACCTCCCAGGCTCAAGTGATCCTCCTGCCTCAGCCCCCTGAGTAGCTGGG
GCTGTAGGTGTGCACTACTATGCTCGGGTAATTTTTTTTTTTTGAAACAAGGTCTTGCTCTTGTCCCCTAGGCTGGAGTGCAGTGGCGTG
ATTTCGGCTCACTGCAACCTCCACCTACTGGGTTCAAGCAATTCTCTTGCCTCAGCCTCCCGAGTAGCTGGGGTTACAGGCATGTACCAC
CACGCCCGGCTAATTTTTGTATTTTTAGTAGAGACAGGGTTTCACCATGTTGGCCAGGCTGGTCTCGAACTCCCGACCTCAGGTGATCTG
CCTGCCTCCCAAAGAATACAACGGGCTGGGCATGGTGGCTTATGCCTGTAATCCCAGCACTTTGGGAGGTTGGGAGTTCAAGACCAGCCT
GACCAACATGGAGAAACCCCGTCTCTACTAAAAGTACAAAATTAGCTGGGCGTGGTGGTGCACGCCTGTAATCCCAGCTACTCGGGAGGC
TTGAGGCAGGAGAACCGCTTGAACCCAGGAGGCAGAGGTTGCAGTGAGCTGAGATCGCACCACTGCACTCCAGCCTGCCTGGTGACAGAG
CGAGACTCCGTCTCAAAAAGAAAAAAGGCTCACGCCTGTAATCCAAACACTTTGGGAGGCCAAGGCAGGTGGATCACCTGAGGTCGGGAG
TGCAAGACCAACCTGGCCAACATGGTGAAACCCCGTCTCTCCTAAAAATACAAAAATTAGCTAGGTGTGATTCCAGGCGCCTGTAGTCCC
AGCTACTTGGGAGGCTGAGGCTGGAGAATCACTTGAACTCAGGAGGTAGAGGTTGCAGTGAGCTGCGATAGCACCACTGCACTCCAGCCT
GTGCGACAGAGGGAGACACCATCTCGAAAAAAAAAAGAAAAATTCTTTTTTTTTTTTTGAGCTGGAGTTTCGCTCTTGTTGTCTAAGCTG
GAGTGCAGGGGTGTGATCTCGGCTAATTGCAGCCTCCGCCTCCTGGGTTCAAGCGATTCTCCAGCCTCAGCCTCCCAAGTAGCTGGGATT
ACAGGCATCCGCCACCACACCCGGCTAATTTTTTGTATTTTCAGTAGAGACGTGGTTTCACCATGTTGGCCGGGCTGGTCTCGAACTCCT
GACCTCAGATGATCCGCCCGCCTCAGCCTCCCAAAATGCTGGGATTACAGGCGTGAGCCACCGCGTCCAGCCAAGAAAAAAAGTTTTTAA
TGAAAGAAACAGAAACTGATGCCATTATATAATGAACCCTAGTACCCATCACCCAGCTTCAGCAGGTGTTAGTATTTTGTGACTCTTTGA
TTTTTTTGTCTTGGGCCTAGGTGAAATGACAATGGATGCTCTGTTGGCTCGATTGAAACTTCTGAATCCAGATGACCTTAGAGAAGAAAT
CGTCAAAGCCGGATTGAAATGTGGACCCATTACATCAACTACAAGGTTCATTTTTGAGAAAAAATTGGCTCAGGCTTTACTGGAGCAAGG
AGGAAGGCTGTCTTCTTTCTACCACCATGAGGCAGGTGTCACAGCTCTCAGCCAGGACCCACAAAGGATTTTGAAGCCAGCTGAAGGGAA
CCCAACTGATCAGGCTGGTTTTTCTGAAGACAGAGATTTTGGTTACAGTGTGGGCCTGAATCCTCCAGAGGAGGAAGCTGTGACATCCAA
GACCTGCTCGGTGCCCCCTAGTGACACCGACACCTACAGAGCTGGAGCGACTGCGTCTAAGGAGCCGCCCCTGTACTATGGGGTGTGTCC
AGTGTATGAGGACGTCCCAGCGAGAAATGAAAGGATCTATGTTTATGAAAATAAAAAGGAAGCATTGCAAGCTGTCAAGATGATCAAAGG
GTCCCGATTTAAAGCTTTTTCTACCAGAGAAGACGCTGAGAAATTTGCTAGAGGAATTTGTGATTATTTCCCTTCTCCAAGCAAAACGTC
CTTACCACTGTCTCCTGTGAAAACAGCTCCACTCTTTAGCAATGACAGGTTGAAAGATGGTTTGTGCTTGTCGGAATCAGAAACAGTCAA
CAAAGAGCGAGCGAACAGTTACAAAAATCCCCGCACGCAGGACCTCACCGCCAAGCTTCGGAAAGCTGTGGAGAAGGGAGAGGAGGACAC
CTTTTCTGACCTTATCTGGAGCAACCCCCGGTATCTGATAGGCTCAGGAGACAACCCCACTATCGTGCAGGAAGGGTGCAGGTACAACGT
GATGCATGTTGCTGCCAAAGAGAACCAGGCTTCCATCTGCCAGCTGACTCTGGACGTCCTGGAGAACCCTGACTTCATGAGGCTGATGTA
CCCTGATGACGACGAGGCCATGCTGCAGAAGCGTATCCGTTACGTGGTGGACCTGTACCTCAACACCCCCGACAAGATGACTGAGGCTGA
TGTGAATCCAAAGGCCTATCCCCTTGCCGATGCCCACCTCACCAAGAAGCTACTGGACCTCGTTCAGCAGTCATGTAACTATAAGCAGCT
TCGGAAAGGAGCCAATGAGGCCACCAAAACCCTCAACAGGGGCATCTCTGAGTTCATCGTGATGGCTGCAGACGCCGAGCCACTGGAGAT
CATTCTGCACCTGCCGCTGCTGTGTGAAGACAAGAATGTGCCCTACGTGTTTGTGCGCTCCAAGCAGGCCCTGGGGAGAGCCTGTGGGGT
CTCCAGGCCTGTCATCGCCTGTTCTGTCACCATCAAAGAAGGCTCGCAGCTGAAACAGCAGATCCAATCCATTCAGCAGTCCATTGAAAG
GCTCTTAGTCTAAACCTGTGGCCTCTGCCACGTGCTCCCTGCCAGCTTCCCCCCTGAGGTTGTGTATCATATTATCTGTGTTAGCATGTA
GTATTTTCAGCTACTCTCTATTGTTATAAAATGTAGTACTAAATCTGGTTTCTGGATTTTTGTGTTGTTTTTGTTCTGTTTTACAGGGTT
GCTATCCCCCTTCCTTTCCTCCCTCCCTCTGCCATCCTTCATCCTTTTATCCTCCCTTTTTGGAACAAGTGTTCAGAGCAGACAGAAGCA
GGGTGGTGGCACCGTTGAAAGGCAGAAAGAGCCAGGAGAAAGCTGATGGAGCCAGGACAGAGATCTGGTTCCAGCTTTCAGCCACTAGCT
TCCTGTTGTGTGCGGGGTGTGGTGGAATTAAACAGCATTCATTGTGTGTCCCTGTGCCTGGCACACAGAATCATTCATACGTGTTCAAGT
GATCAAGGGGTTTCATTTGCTCTTGGGGGATTAGGTATCATTTGGGGAGGAAGCATGTGTTCTGTGAGGTTGTTCGGCTATGTCCAAGTG
TCGTTTACTAATGTACCCCTGCTGTTTGCTTTTGGTAATGTGATGTTGATGTTCTCCCCCTACCCACAACCATGCCCTTGAGGGTAGCAG
GGCAGCAGCATACCAAAGAGATGTGCTGCAGGACTCCGGAGGCAGCCTGGGTGGGTGAGCCATGGGGCAGTTGACCTGGGTCTTGAAAGA
GTCGGGAGTGACAAGCTCAGAGAGCATGAACTGATGCTGGCATGAAGGATTCCAGGAAGATCATGGAGACCTGGCTGGTAGCTGTAACAG
AGATGGTGGAGTCCAAGGAAACAGCCTGTCTCTGGTGAATGGGACTTTCTTTGGTGGACACTTGGCACCAGCTCTGAGAGCCCTTCCCCT
GTGTCCTGCCACCATGTGGGTCAGATGTACTCTCTGTCACATGAGGAGAGTGCTAGTTCATGTGTTCTCCATTCTTGTGAGCATCCTAAT

>4500_4500_16_ANKLE2-NHP2L1_ANKLE2_chr12_133324418_ENST00000539605_NHP2L1_chr22_42076368_ENST00000215956_length(amino acids)=480AA_BP=353
MGLGEMTMDALLARLKLLNPDDLREEIVKAGLKCGPITSTTRFIFEKKLAQALLEQGGRLSSFYHHEAGVTALSQDPQRILKPAEGNPTD
QAGFSEDRDFGYSVGLNPPEEEAVTSKTCSVPPSDTDTYRAGATASKEPPLYYGVCPVYEDVPARNERIYVYENKKEALQAVKMIKGSRF
KAFSTREDAEKFARGICDYFPSPSKTSLPLSPVKTAPLFSNDRLKDGLCLSESETVNKERANSYKNPRTQDLTAKLRKAVEKGEEDTFSD
LIWSNPRYLIGSGDNPTIVQEGCRYNVMHVAAKENQASICQLTLDVLENPDFMRLMYPDDDEAMLQKRIRYVVDLYLNTPDKMTEADVNP
KAYPLADAHLTKKLLDLVQQSCNYKQLRKGANEATKTLNRGISEFIVMAADAEPLEIILHLPLLCEDKNVPYVFVRSKQALGRACGVSRP

--------------------------------------------------------------
>4500_4500_17_ANKLE2-NHP2L1_ANKLE2_chr12_133324418_ENST00000539605_NHP2L1_chr22_42076368_ENST00000355257_length(transcript)=9116nt_BP=7729nt
GCCCGGGCGGCGGCGATGCTGTGGCCGCGGCTGGCGGCGGCCGAGTGGGCGGCGCTGGCCTGGGAGCTGCTGGGCGCCTCGGTGCTGCTG
ATCGCTGTGCGGTGGCTGGTGCGGCGGCTGGGCCCGCGGCCGGGAGGTCTGGGCCGCAGCGGGACCCCAGTTCCTCCGCCAAGCGCGGCC
GCCGCCCCCGCCTCAGGTAAGGCCCAGGCGGTCGCTGGGTCCCCGCACCCTGGCCCCTTCCCCGCCCCGACGCCCTCCTCGGGCCTGGGG
TCCCGGCCGCGCCCCTGGAGCCGGCAGCAGTTGGGCGAGGCGGCCGGGGAAACCAGGGCCGGTCGGGAAAGGCCATTCCGGCCGCGGAAA
GGGCAGTTGCGGGGACTTGGCTTCCCGGGCCGGGGGCGGAGGGGCCACGCCGGGTTCGGGGGTGAGAGCTTTCCCGGGCCCTGGAGCAGC
CTCCGGGGAAGGCGGCGGGGGCCCGGCGAGGCGTTAGCGGAGACTCTTGCTGCGGTCTCTCGAGACCTGGGGAGGGATGGCCCAAAGGAG
GGCGGCGCGGGGAGGAAACCCCTGGGTCCCGGATGTGTTTGGAACGTGAAGCCATTGCGGTTACTGGTCATGGAACATAAGGCAGAGACG
GAAAAGGCAAATGTAACTCAGGGGTTTGGGGCCAGAGGAAGAGGGAGAAGGTGGCCATTTATTGCTTTGCGGTAGACTGTCGGGTCTGGG
TGATGTGGAGATCAGAGGTGGGTTTTGGTCGTTTTAAGTTTGAGGTAACTGATACAGTGAACTGTGTATTTCAGCTCCATCCCCTTTTCC
TGGCATACAACTCTTGAAATCCCGGGAACCTCCAAAGTGATGTCTTTTGTAGGCTGAGTGGACTGGTGGCCGGCAGCCCCTAGGGAGCTT
CTGGATGGGGCTGGTCGCAGGAAAGACCAAGGCAGGGTTAGAGGTTCTGGGGACTTTCAGCCCCACCCCCAACCTCTGGGGAGGAGAGAG
GGGTGAAGGTTGCGTTGATCACCAGTGGCTGATGAATCACGCCTGTGAAATGAAGTTCCTGTAAAAACCCAAAAGGGCTGGGTTCAGGGA
GCTTCCAGATAGTACGTGGGGGTTCCTGGAGGCGGTGCCCAGAGAGGCCCTGAATTTCCAAGCGCTTCCCCCCGGTTTTACGTCACGCAT
CTCTTCACCTGTATTCTTTGTAATCCTTTATACTCTGCTGGTAAGTGTAAGTAAAACATGTCTGTGAGTTCGGGAGCCACTCTAGCAAAT
TACCGCAACCTGAGGAGGTCACCGGGTTACGCCCCGTCGGTCCCAAGCGCAGGTCAAACAACCTGGGCACTGGAAGTGGGGGGCAGTCTT
GCGGGGCTGAGCCGTTAACCTGTGGGGGTCTGCTGGTATCTCCAGGAAGACGCTGTCAGAATAGATGACTGAATTAGGATGACAGACGAC
ACCCAGCCTGTGTCCACTGCAGAACTGACGACCTGCGTGATTTGTGGGGAGAAAATCCCCACATACCTGGTGTCCGAAGCATGTTGCAAG
ACTAGTGGGAGAAACTGAGTTTGTTTTTACTCTAAATTGTCAGACTGTTAGTCACTGCGGAGAGGTGCTTTCTGATGATTGAGTGGGGAT
TCCTGTCCAATTGTGTGAGTTTGTGTCTCGGCCCTACCACTTTTTTTTTTTTTTTTTTTTGAAATGTAGTCTCGCCCTGTGGCCCAGGCT
GGAGTGCAGTGGCGCGATCTCGGCTCACTGCAAGCTCCGCCTCCCGGGTTCAAGCGATTCTCCTGCATCAGCCTCCCGAGTAGCTGGGAT
TACAGGCGCCTGCCACCACGCCCGGCTAATTTTTGTATTTTTAATAGAGACGGGGTTTCACCATGTTGGCCAGGATGGTCTCGAATTCCT
GACCTCAGGTGATCCACCTGCCTCAGCTTCCCAAAATGCTGGGATTACAGGTGTGAGCCATCGCACCGGGCCCTACCACTTATTGCTGTG
GGCTTAACCTGTTTTCAGCCTGCTCTTTTAGGAATGGGGATGATAGTGATACCTGGTTAGGCTTTTTTGGGAGTTGGGTAAGTGCAGCAC
TTGGTATGTGTTAAGCACCTCTGAGTGCTGTTACTGTCACCAGCGGCATCATCCAGGCAGAGCTGCGGACAAGGTGGCGGCGGGTGAGGG
TGGTGTTTTGAGAATGGCTGAAATAAAAAAATACTGATTTATTTTATATAAAAATATGTTTTTATATATGATGTATAATATACGTATATC
ATGGCATATGATACGTGTATATCATATAGCACATATAGTATACATATATATAGTCAGCAGAGATTTAGAGAAACTGGGCCTCGTGCATTG
CAGGTGGGGACGGTAAGTGGTGCAGCTACTCTGGGAATCAGCCTGGCAGGTTTTTAGGAAGTTAAACCTGCCCTGCATTCCTGAGCTTTT
ATTAGACAAATGAAAACTATTTTCACACAAAAACCCATATTTAATGTTCATAGCAACTTTATTTGTAATTACCAGAAACTGAAATAACTC
AAATGGTTAAACTTGCACACTGATACCCCGGGGTGCCACTCCGCAGCGATCCTCTCTGCCACGTGGGTGCCCCGGGGTGCCACTCTGCAT
GATCCACTCTGCCACGTGGGTGCCCCGGGGTGCCACTCCGCAGCGATCCTCTCTGCCACGTGGGTGCCCCGGGGTGCCACTCTGCGTGAT
CCACTCTGCCACGTGGGTGCCCCGGGGTGCCACTCCGCAGCGATCCTCTCTGCCACGTGGGTGCCCCGGGGTGCCACTCCGCAGCGATCC
ACTCTGCCACGTGGGTGCCCCGGGGTGCCACTCCGCAGCGATCCTCTCTGCCACGTGGGTGCCCCGGGGTGCCACACTGCGTGATCCACT
CTGCCACGTGGGTGCCCCGGGGTGCCACTCCGCAGCGATCCACTCTGCCACGTGGGTGGATCTCAAGGGCATTATGCTGAATAGGAAAAG
CCAGTCTCAAAAGTTGTGTACTTGGCCGGTTGCGGTGGCTCATGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGCAGGTGGATCACAAG
GTCAGGAGTTCAAGATCAGCCTGGCCAACATGGTGAGGCAGTCTCCACTAAAAATACAAAAAAATAGCGGGGCGTGGTGGCAGGTACCTG
TAATCCCAGCTACTCGGGAGGCTGAGGCAGCAGAATTGCTTGAACCCAGGAGGTGGAGGTTGCGGTGAGCAGAGATCGTGCCACTGCACT
CCAGCCTGGGCGACAGAGCAAGACTCCATCTCAAAAAAAAAAAAATTGTTAATGGAACATTATAACCCAGTGTTCAGACCTAGCTGTTTC
TCACATCTTTACCCATCGATCTGTCAAAGACCTTGTGATCATACTGATACTTCCAATTTCAATGCGACGTCCGCGGGTTTATTCTTTTTT
TTTTAGGTGGAGTCTCACTCTGTTGTCCAGGCTGGAGACTCACTGCAACCTCTGCCTGCCCAGTTCAAGCGATTCTCCCACCTAGCCTGC
TGAGTAGCTGGGATGACAGGTGCATGCCACCATGCCTGGCTAATTTTTGTGTTTTTAGTAGACACCTGGTTTCATCATGTTGGCCAGGCT
GGTCTCAAACACCTGACCTCAAATGATCCATGCACCTTGGCCTCCCAAAGTGCTGGGATTACCAGCATGAGCCACCGTGTCCGGCTCCCT
GGCTTTATTCTAATGCAAGAGTCAGTAAACTGTGGTCCAAACTGGCCCCCACCTATTTTCCTTAGTAAAGTTTTATTGGAATACAACCAT
ACCCTTTTGTTTATGTATATCTGTGGCTGTTCTTTTTTTTTTTTTTTTTGGAGACGGGGTCTTGCTCTGTTGCCCAGGTTGGAGTGCAGT
GGCACAAACAGGGCTCACTGCATCCTCAAACTCTTAGGCTTAATTTATCCTCCTTCCTCAGCCCCCCAAGTAGTTGGAACCACAGGTGCA
CGTCACCACACTCAGCTAATTTTTTTTTTTTGAGACGGAGTCTCGCTCTGTCGCCCAGGCTGGAGTGCAGTGCCGCCATCTCTGCTCACT
GCAAGTTCTGCCCCCTGGGTTCACACCATTCTCCTGCCTCAGCCTCCTGAGTAGCTGGGACTACAGGCGCCCGCCACCATGGCCGGCTAA
TTTTTTAGTATTTTTAGTAGAGACAGGGTTTCACCGTGTTTGCCAGGATAGTCTCAATCTCCTGACCTCATGATCCACCTGCCTCGGCCT
CCCAAAGTGCTGGGATTACAGGCATGAGTCACCGCGCCCAGCCATCAGATAATTTTTAAAGTTTTTGTAGAAAGGGTGTCGCTGTGTTAC
CCAGGCTGGTCTTGAACTCCTGGGCTCAAGTGATCTTCCCGCCTCGGCCTCCCCAAGCGCTGGGGTGACAGGTGTGAGCCGCCACACGCG
GCCTGTGGCTGTTCTGAGCACTCACGTGGCCTTTGGCTCATAGAGTCTGAGATGCTTACTCTCTCGCCCTTTACAGGAATCGTTTGCTGA
AACCCTGTTCTCACTCCCACTTTCCTTTCTGTCATTGAGAGTCCTGGCTCTCATCAGCCACCGTGTATTCCAATTATTTGCTTTGCCCTA
GAGTCCACAGAAAATAGCTTTAGGTGTGTTAACCTATACCATTGTGAAAACATCTACTGCCTAGAGCCTGTTCACACGGTAATGGTGCAC
AGTCCTTTTTGTCTTTCTCCTTAGAGCACCTAGTCACTCACTGTTTTCCAAAGTTACGTAGGTTAGCTTCCCCTGTGTTACTCACTTGTA
ATACAGTTAGGTGCATTTCTTCTGGCTAGTATTCCATGTGGGTGTCTCCCCCATCTTTTTGTTTATTTACTTATTTCTTTTTTTTTTGTT
TTTTTTGTTGTTGTTGTTTTATTGAGGTGGAGTCTCGCTCTGTTGCCCAGGCTGGAGTGTAGTGGTGCGATCTCGGCTCACTGTGACCTC
TGCCTCCTGGGTTCCAGCGAGTCTCCTGCCTCAGGTTCCCGAGTAGCTGGGATTACAGGTGCCCGCCACTGCGCCTGTCTAATTTTTGTA
TTTTTTTTTTAGTAGAGATGGGGTTTCACCATCTTGGCCAGGCTGGTCTCGAACTGCTGACCTCGTGATCCACCCACCTCGGTCTCCCAA
AGTGCTGCGATTACAGGCGTGAGCCACCGCACCCGGCTTTACTTATTTGAGTATGTAAATCACGAACATGTTTTTAAAAGTCAGAACCCT
GTAGAAACTTAAATTCAGATGTATTACTCCCCCCCGCCATCTTTTTTTTTGTTGTTGTTGTTGAGACAGGGTCTGATTCTGTCACCCAGG
CTGGAGTGCAGGGTTGCCATCTCAGCTCGTGGTGGCATCCACCTCCCAGGCTCAAGTGATCCTCCTGCCTCAGCCCCCTGAGTAGCTGGG
GCTGTAGGTGTGCACTACTATGCTCGGGTAATTTTTTTTTTTTGAAACAAGGTCTTGCTCTTGTCCCCTAGGCTGGAGTGCAGTGGCGTG
ATTTCGGCTCACTGCAACCTCCACCTACTGGGTTCAAGCAATTCTCTTGCCTCAGCCTCCCGAGTAGCTGGGGTTACAGGCATGTACCAC
CACGCCCGGCTAATTTTTGTATTTTTAGTAGAGACAGGGTTTCACCATGTTGGCCAGGCTGGTCTCGAACTCCCGACCTCAGGTGATCTG
CCTGCCTCCCAAAGAATACAACGGGCTGGGCATGGTGGCTTATGCCTGTAATCCCAGCACTTTGGGAGGTTGGGAGTTCAAGACCAGCCT
GACCAACATGGAGAAACCCCGTCTCTACTAAAAGTACAAAATTAGCTGGGCGTGGTGGTGCACGCCTGTAATCCCAGCTACTCGGGAGGC
TTGAGGCAGGAGAACCGCTTGAACCCAGGAGGCAGAGGTTGCAGTGAGCTGAGATCGCACCACTGCACTCCAGCCTGCCTGGTGACAGAG
CGAGACTCCGTCTCAAAAAGAAAAAAGGCTCACGCCTGTAATCCAAACACTTTGGGAGGCCAAGGCAGGTGGATCACCTGAGGTCGGGAG
TGCAAGACCAACCTGGCCAACATGGTGAAACCCCGTCTCTCCTAAAAATACAAAAATTAGCTAGGTGTGATTCCAGGCGCCTGTAGTCCC
AGCTACTTGGGAGGCTGAGGCTGGAGAATCACTTGAACTCAGGAGGTAGAGGTTGCAGTGAGCTGCGATAGCACCACTGCACTCCAGCCT
GTGCGACAGAGGGAGACACCATCTCGAAAAAAAAAAGAAAAATTCTTTTTTTTTTTTTGAGCTGGAGTTTCGCTCTTGTTGTCTAAGCTG
GAGTGCAGGGGTGTGATCTCGGCTAATTGCAGCCTCCGCCTCCTGGGTTCAAGCGATTCTCCAGCCTCAGCCTCCCAAGTAGCTGGGATT
ACAGGCATCCGCCACCACACCCGGCTAATTTTTTGTATTTTCAGTAGAGACGTGGTTTCACCATGTTGGCCGGGCTGGTCTCGAACTCCT
GACCTCAGATGATCCGCCCGCCTCAGCCTCCCAAAATGCTGGGATTACAGGCGTGAGCCACCGCGTCCAGCCAAGAAAAAAAGTTTTTAA
TGAAAGAAACAGAAACTGATGCCATTATATAATGAACCCTAGTACCCATCACCCAGCTTCAGCAGGTGTTAGTATTTTGTGACTCTTTGA
TTTTTTTGTCTTGGGCCTAGGTGAAATGACAATGGATGCTCTGTTGGCTCGATTGAAACTTCTGAATCCAGATGACCTTAGAGAAGAAAT
CGTCAAAGCCGGATTGAAATGTGGACCCATTACATCAACTACAAGGTTCATTTTTGAGAAAAAATTGGCTCAGGCTTTACTGGAGCAAGG
AGGAAGGCTGTCTTCTTTCTACCACCATGAGGCAGGTGTCACAGCTCTCAGCCAGGACCCACAAAGGATTTTGAAGCCAGCTGAAGGGAA
CCCAACTGATCAGGCTGGTTTTTCTGAAGACAGAGATTTTGGTTACAGTGTGGGCCTGAATCCTCCAGAGGAGGAAGCTGTGACATCCAA
GACCTGCTCGGTGCCCCCTAGTGACACCGACACCTACAGAGCTGGAGCGACTGCGTCTAAGGAGCCGCCCCTGTACTATGGGGTGTGTCC
AGTGTATGAGGACGTCCCAGCGAGAAATGAAAGGATCTATGTTTATGAAAATAAAAAGGAAGCATTGCAAGCTGTCAAGATGATCAAAGG
GTCCCGATTTAAAGCTTTTTCTACCAGAGAAGACGCTGAGAAATTTGCTAGAGGAATTTGTGATTATTTCCCTTCTCCAAGCAAAACGTC
CTTACCACTGTCTCCTGTGAAAACAGCTCCACTCTTTAGCAATGACAGGTTGAAAGATGGTTTGTGCTTGTCGGAATCAGAAACAGTCAA
CAAAGAGCGAGCGAACAGTTACAAAAATCCCCGCACGCAGGACCTCACCGCCAAGCTTCGGAAAGCTGTGGAGAAGGGAGAGGAGGACAC
CTTTTCTGACCTTATCTGGAGCAACCCCCGGTATCTGATAGGCTCAGGAGACAACCCCACTATCGTGCAGGAAGGGTGCAGGTACAACGT
GATGCATGTTGCTGCCAAAGAGAACCAGGCTTCCATCTGCCAGCTGACTCTGGACGTCCTGGAGAACCCTGACTTCATGAGGCTGATGTA
CCCTGATGACGACGAGGCCATGCTGCAGAAGCGTATCCGTTACGTGGTGGACCTGTACCTCAACACCCCCGACAAGATGACTGAGGCTGA
TGTGAATCCAAAGGCCTATCCCCTTGCCGATGCCCACCTCACCAAGAAGCTACTGGACCTCGTTCAGCAGTCATGTAACTATAAGCAGCT
TCGGAAAGGAGCCAATGAGGCCACCAAAACCCTCAACAGGGGCATCTCTGAGTTCATCGTGATGGCTGCAGACGCCGAGCCACTGGAGAT
CATTCTGCACCTGCCGCTGCTGTGTGAAGACAAGAATGTGCCCTACGTGTTTGTGCGCTCCAAGCAGGCCCTGGGGAGAGCCTGTGGGGT
CTCCAGGCCTGTCATCGCCTGTTCTGTCACCATCAAAGAAGGCTCGCAGCTGAAACAGCAGATCCAATCCATTCAGCAGTCCATTGAAAG
GCTCTTAGTCTAAACCTGTGGCCTCTGCCACGTGCTCCCTGCCAGCTTCCCCCCTGAGGTTGTGTATCATATTATCTGTGTTAGCATGTA
GTATTTTCAGCTACTCTCTATTGTTATAAAATGTAGTACTAAATCTGGTTTCTGGATTTTTGTGTTGTTTTTGTTCTGTTTTACAGGGTT
GCTATCCCCCTTCCTTTCCTCCCTCCCTCTGCCATCCTTCATCCTTTTATCCTCCCTTTTTGGAACAAGTGTTCAGAGCAGACAGAAGCA
GGGTGGTGGCACCGTTGAAAGGCAGAAAGAGCCAGGAGAAAGCTGATGGAGCCAGGACAGAGATCTGGTTCCAGCTTTCAGCCACTAGCT
TCCTGTTGTGTGCGGGGTGTGGTGGAATTAAACAGCATTCATTGTGTGTCCCTGTGCCTGGCACACAGAATCATTCATACGTGTTCAAGT
GATCAAGGGGTTTCATTTGCTCTTGGGGGATTAGGTATCATTTGGGGAGGAAGCATGTGTTCTGTGAGGTTGTTCGGCTATGTCCAAGTG
TCGTTTACTAATGTACCCCTGCTGTTTGCTTTTGGTAATGTGATGTTGATGTTCTCCCCCTACCCACAACCATGCCCTTGAGGGTAGCAG
GGCAGCAGCATACCAAAGAGATGTGCTGCAGGACTCCGGAGGCAGCCTGGGTGGGTGAGCCATGGGGCAGTTGACCTGGGTCTTGAAAGA
GTCGGGAGTGACAAGCTCAGAGAGCATGAACTGATGCTGGCATGAAGGATTCCAGGAAGATCATGGAGACCTGGCTGGTAGCTGTAACAG
AGATGGTGGAGTCCAAGGAAACAGCCTGTCTCTGGTGAATGGGACTTTCTTTGGTGGACACTTGGCACCAGCTCTGAGAGCCCTTCCCCT
GTGTCCTGCCACCATGTGGGTCAGATGTACTCTCTGTCACATGAGGAGAGTGCTAGTTCATGTGTTCTCCATTCTTGTGAGCATCCTAAT

>4500_4500_17_ANKLE2-NHP2L1_ANKLE2_chr12_133324418_ENST00000539605_NHP2L1_chr22_42076368_ENST00000355257_length(amino acids)=480AA_BP=353
MGLGEMTMDALLARLKLLNPDDLREEIVKAGLKCGPITSTTRFIFEKKLAQALLEQGGRLSSFYHHEAGVTALSQDPQRILKPAEGNPTD
QAGFSEDRDFGYSVGLNPPEEEAVTSKTCSVPPSDTDTYRAGATASKEPPLYYGVCPVYEDVPARNERIYVYENKKEALQAVKMIKGSRF
KAFSTREDAEKFARGICDYFPSPSKTSLPLSPVKTAPLFSNDRLKDGLCLSESETVNKERANSYKNPRTQDLTAKLRKAVEKGEEDTFSD
LIWSNPRYLIGSGDNPTIVQEGCRYNVMHVAAKENQASICQLTLDVLENPDFMRLMYPDDDEAMLQKRIRYVVDLYLNTPDKMTEADVNP
KAYPLADAHLTKKLLDLVQQSCNYKQLRKGANEATKTLNRGISEFIVMAADAEPLEIILHLPLLCEDKNVPYVFVRSKQALGRACGVSRP

--------------------------------------------------------------
>4500_4500_18_ANKLE2-NHP2L1_ANKLE2_chr12_133324418_ENST00000539605_NHP2L1_chr22_42076368_ENST00000401959_length(transcript)=9079nt_BP=7729nt
GCCCGGGCGGCGGCGATGCTGTGGCCGCGGCTGGCGGCGGCCGAGTGGGCGGCGCTGGCCTGGGAGCTGCTGGGCGCCTCGGTGCTGCTG
ATCGCTGTGCGGTGGCTGGTGCGGCGGCTGGGCCCGCGGCCGGGAGGTCTGGGCCGCAGCGGGACCCCAGTTCCTCCGCCAAGCGCGGCC
GCCGCCCCCGCCTCAGGTAAGGCCCAGGCGGTCGCTGGGTCCCCGCACCCTGGCCCCTTCCCCGCCCCGACGCCCTCCTCGGGCCTGGGG
TCCCGGCCGCGCCCCTGGAGCCGGCAGCAGTTGGGCGAGGCGGCCGGGGAAACCAGGGCCGGTCGGGAAAGGCCATTCCGGCCGCGGAAA
GGGCAGTTGCGGGGACTTGGCTTCCCGGGCCGGGGGCGGAGGGGCCACGCCGGGTTCGGGGGTGAGAGCTTTCCCGGGCCCTGGAGCAGC
CTCCGGGGAAGGCGGCGGGGGCCCGGCGAGGCGTTAGCGGAGACTCTTGCTGCGGTCTCTCGAGACCTGGGGAGGGATGGCCCAAAGGAG
GGCGGCGCGGGGAGGAAACCCCTGGGTCCCGGATGTGTTTGGAACGTGAAGCCATTGCGGTTACTGGTCATGGAACATAAGGCAGAGACG
GAAAAGGCAAATGTAACTCAGGGGTTTGGGGCCAGAGGAAGAGGGAGAAGGTGGCCATTTATTGCTTTGCGGTAGACTGTCGGGTCTGGG
TGATGTGGAGATCAGAGGTGGGTTTTGGTCGTTTTAAGTTTGAGGTAACTGATACAGTGAACTGTGTATTTCAGCTCCATCCCCTTTTCC
TGGCATACAACTCTTGAAATCCCGGGAACCTCCAAAGTGATGTCTTTTGTAGGCTGAGTGGACTGGTGGCCGGCAGCCCCTAGGGAGCTT
CTGGATGGGGCTGGTCGCAGGAAAGACCAAGGCAGGGTTAGAGGTTCTGGGGACTTTCAGCCCCACCCCCAACCTCTGGGGAGGAGAGAG
GGGTGAAGGTTGCGTTGATCACCAGTGGCTGATGAATCACGCCTGTGAAATGAAGTTCCTGTAAAAACCCAAAAGGGCTGGGTTCAGGGA
GCTTCCAGATAGTACGTGGGGGTTCCTGGAGGCGGTGCCCAGAGAGGCCCTGAATTTCCAAGCGCTTCCCCCCGGTTTTACGTCACGCAT
CTCTTCACCTGTATTCTTTGTAATCCTTTATACTCTGCTGGTAAGTGTAAGTAAAACATGTCTGTGAGTTCGGGAGCCACTCTAGCAAAT
TACCGCAACCTGAGGAGGTCACCGGGTTACGCCCCGTCGGTCCCAAGCGCAGGTCAAACAACCTGGGCACTGGAAGTGGGGGGCAGTCTT
GCGGGGCTGAGCCGTTAACCTGTGGGGGTCTGCTGGTATCTCCAGGAAGACGCTGTCAGAATAGATGACTGAATTAGGATGACAGACGAC
ACCCAGCCTGTGTCCACTGCAGAACTGACGACCTGCGTGATTTGTGGGGAGAAAATCCCCACATACCTGGTGTCCGAAGCATGTTGCAAG
ACTAGTGGGAGAAACTGAGTTTGTTTTTACTCTAAATTGTCAGACTGTTAGTCACTGCGGAGAGGTGCTTTCTGATGATTGAGTGGGGAT
TCCTGTCCAATTGTGTGAGTTTGTGTCTCGGCCCTACCACTTTTTTTTTTTTTTTTTTTTGAAATGTAGTCTCGCCCTGTGGCCCAGGCT
GGAGTGCAGTGGCGCGATCTCGGCTCACTGCAAGCTCCGCCTCCCGGGTTCAAGCGATTCTCCTGCATCAGCCTCCCGAGTAGCTGGGAT
TACAGGCGCCTGCCACCACGCCCGGCTAATTTTTGTATTTTTAATAGAGACGGGGTTTCACCATGTTGGCCAGGATGGTCTCGAATTCCT
GACCTCAGGTGATCCACCTGCCTCAGCTTCCCAAAATGCTGGGATTACAGGTGTGAGCCATCGCACCGGGCCCTACCACTTATTGCTGTG
GGCTTAACCTGTTTTCAGCCTGCTCTTTTAGGAATGGGGATGATAGTGATACCTGGTTAGGCTTTTTTGGGAGTTGGGTAAGTGCAGCAC
TTGGTATGTGTTAAGCACCTCTGAGTGCTGTTACTGTCACCAGCGGCATCATCCAGGCAGAGCTGCGGACAAGGTGGCGGCGGGTGAGGG
TGGTGTTTTGAGAATGGCTGAAATAAAAAAATACTGATTTATTTTATATAAAAATATGTTTTTATATATGATGTATAATATACGTATATC
ATGGCATATGATACGTGTATATCATATAGCACATATAGTATACATATATATAGTCAGCAGAGATTTAGAGAAACTGGGCCTCGTGCATTG
CAGGTGGGGACGGTAAGTGGTGCAGCTACTCTGGGAATCAGCCTGGCAGGTTTTTAGGAAGTTAAACCTGCCCTGCATTCCTGAGCTTTT
ATTAGACAAATGAAAACTATTTTCACACAAAAACCCATATTTAATGTTCATAGCAACTTTATTTGTAATTACCAGAAACTGAAATAACTC
AAATGGTTAAACTTGCACACTGATACCCCGGGGTGCCACTCCGCAGCGATCCTCTCTGCCACGTGGGTGCCCCGGGGTGCCACTCTGCAT
GATCCACTCTGCCACGTGGGTGCCCCGGGGTGCCACTCCGCAGCGATCCTCTCTGCCACGTGGGTGCCCCGGGGTGCCACTCTGCGTGAT
CCACTCTGCCACGTGGGTGCCCCGGGGTGCCACTCCGCAGCGATCCTCTCTGCCACGTGGGTGCCCCGGGGTGCCACTCCGCAGCGATCC
ACTCTGCCACGTGGGTGCCCCGGGGTGCCACTCCGCAGCGATCCTCTCTGCCACGTGGGTGCCCCGGGGTGCCACACTGCGTGATCCACT
CTGCCACGTGGGTGCCCCGGGGTGCCACTCCGCAGCGATCCACTCTGCCACGTGGGTGGATCTCAAGGGCATTATGCTGAATAGGAAAAG
CCAGTCTCAAAAGTTGTGTACTTGGCCGGTTGCGGTGGCTCATGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGCAGGTGGATCACAAG
GTCAGGAGTTCAAGATCAGCCTGGCCAACATGGTGAGGCAGTCTCCACTAAAAATACAAAAAAATAGCGGGGCGTGGTGGCAGGTACCTG
TAATCCCAGCTACTCGGGAGGCTGAGGCAGCAGAATTGCTTGAACCCAGGAGGTGGAGGTTGCGGTGAGCAGAGATCGTGCCACTGCACT
CCAGCCTGGGCGACAGAGCAAGACTCCATCTCAAAAAAAAAAAAATTGTTAATGGAACATTATAACCCAGTGTTCAGACCTAGCTGTTTC
TCACATCTTTACCCATCGATCTGTCAAAGACCTTGTGATCATACTGATACTTCCAATTTCAATGCGACGTCCGCGGGTTTATTCTTTTTT
TTTTAGGTGGAGTCTCACTCTGTTGTCCAGGCTGGAGACTCACTGCAACCTCTGCCTGCCCAGTTCAAGCGATTCTCCCACCTAGCCTGC
TGAGTAGCTGGGATGACAGGTGCATGCCACCATGCCTGGCTAATTTTTGTGTTTTTAGTAGACACCTGGTTTCATCATGTTGGCCAGGCT
GGTCTCAAACACCTGACCTCAAATGATCCATGCACCTTGGCCTCCCAAAGTGCTGGGATTACCAGCATGAGCCACCGTGTCCGGCTCCCT
GGCTTTATTCTAATGCAAGAGTCAGTAAACTGTGGTCCAAACTGGCCCCCACCTATTTTCCTTAGTAAAGTTTTATTGGAATACAACCAT
ACCCTTTTGTTTATGTATATCTGTGGCTGTTCTTTTTTTTTTTTTTTTTGGAGACGGGGTCTTGCTCTGTTGCCCAGGTTGGAGTGCAGT
GGCACAAACAGGGCTCACTGCATCCTCAAACTCTTAGGCTTAATTTATCCTCCTTCCTCAGCCCCCCAAGTAGTTGGAACCACAGGTGCA
CGTCACCACACTCAGCTAATTTTTTTTTTTTGAGACGGAGTCTCGCTCTGTCGCCCAGGCTGGAGTGCAGTGCCGCCATCTCTGCTCACT
GCAAGTTCTGCCCCCTGGGTTCACACCATTCTCCTGCCTCAGCCTCCTGAGTAGCTGGGACTACAGGCGCCCGCCACCATGGCCGGCTAA
TTTTTTAGTATTTTTAGTAGAGACAGGGTTTCACCGTGTTTGCCAGGATAGTCTCAATCTCCTGACCTCATGATCCACCTGCCTCGGCCT
CCCAAAGTGCTGGGATTACAGGCATGAGTCACCGCGCCCAGCCATCAGATAATTTTTAAAGTTTTTGTAGAAAGGGTGTCGCTGTGTTAC
CCAGGCTGGTCTTGAACTCCTGGGCTCAAGTGATCTTCCCGCCTCGGCCTCCCCAAGCGCTGGGGTGACAGGTGTGAGCCGCCACACGCG
GCCTGTGGCTGTTCTGAGCACTCACGTGGCCTTTGGCTCATAGAGTCTGAGATGCTTACTCTCTCGCCCTTTACAGGAATCGTTTGCTGA
AACCCTGTTCTCACTCCCACTTTCCTTTCTGTCATTGAGAGTCCTGGCTCTCATCAGCCACCGTGTATTCCAATTATTTGCTTTGCCCTA
GAGTCCACAGAAAATAGCTTTAGGTGTGTTAACCTATACCATTGTGAAAACATCTACTGCCTAGAGCCTGTTCACACGGTAATGGTGCAC
AGTCCTTTTTGTCTTTCTCCTTAGAGCACCTAGTCACTCACTGTTTTCCAAAGTTACGTAGGTTAGCTTCCCCTGTGTTACTCACTTGTA
ATACAGTTAGGTGCATTTCTTCTGGCTAGTATTCCATGTGGGTGTCTCCCCCATCTTTTTGTTTATTTACTTATTTCTTTTTTTTTTGTT
TTTTTTGTTGTTGTTGTTTTATTGAGGTGGAGTCTCGCTCTGTTGCCCAGGCTGGAGTGTAGTGGTGCGATCTCGGCTCACTGTGACCTC
TGCCTCCTGGGTTCCAGCGAGTCTCCTGCCTCAGGTTCCCGAGTAGCTGGGATTACAGGTGCCCGCCACTGCGCCTGTCTAATTTTTGTA
TTTTTTTTTTAGTAGAGATGGGGTTTCACCATCTTGGCCAGGCTGGTCTCGAACTGCTGACCTCGTGATCCACCCACCTCGGTCTCCCAA
AGTGCTGCGATTACAGGCGTGAGCCACCGCACCCGGCTTTACTTATTTGAGTATGTAAATCACGAACATGTTTTTAAAAGTCAGAACCCT
GTAGAAACTTAAATTCAGATGTATTACTCCCCCCCGCCATCTTTTTTTTTGTTGTTGTTGTTGAGACAGGGTCTGATTCTGTCACCCAGG
CTGGAGTGCAGGGTTGCCATCTCAGCTCGTGGTGGCATCCACCTCCCAGGCTCAAGTGATCCTCCTGCCTCAGCCCCCTGAGTAGCTGGG
GCTGTAGGTGTGCACTACTATGCTCGGGTAATTTTTTTTTTTTGAAACAAGGTCTTGCTCTTGTCCCCTAGGCTGGAGTGCAGTGGCGTG
ATTTCGGCTCACTGCAACCTCCACCTACTGGGTTCAAGCAATTCTCTTGCCTCAGCCTCCCGAGTAGCTGGGGTTACAGGCATGTACCAC
CACGCCCGGCTAATTTTTGTATTTTTAGTAGAGACAGGGTTTCACCATGTTGGCCAGGCTGGTCTCGAACTCCCGACCTCAGGTGATCTG
CCTGCCTCCCAAAGAATACAACGGGCTGGGCATGGTGGCTTATGCCTGTAATCCCAGCACTTTGGGAGGTTGGGAGTTCAAGACCAGCCT
GACCAACATGGAGAAACCCCGTCTCTACTAAAAGTACAAAATTAGCTGGGCGTGGTGGTGCACGCCTGTAATCCCAGCTACTCGGGAGGC
TTGAGGCAGGAGAACCGCTTGAACCCAGGAGGCAGAGGTTGCAGTGAGCTGAGATCGCACCACTGCACTCCAGCCTGCCTGGTGACAGAG
CGAGACTCCGTCTCAAAAAGAAAAAAGGCTCACGCCTGTAATCCAAACACTTTGGGAGGCCAAGGCAGGTGGATCACCTGAGGTCGGGAG
TGCAAGACCAACCTGGCCAACATGGTGAAACCCCGTCTCTCCTAAAAATACAAAAATTAGCTAGGTGTGATTCCAGGCGCCTGTAGTCCC
AGCTACTTGGGAGGCTGAGGCTGGAGAATCACTTGAACTCAGGAGGTAGAGGTTGCAGTGAGCTGCGATAGCACCACTGCACTCCAGCCT
GTGCGACAGAGGGAGACACCATCTCGAAAAAAAAAAGAAAAATTCTTTTTTTTTTTTTGAGCTGGAGTTTCGCTCTTGTTGTCTAAGCTG
GAGTGCAGGGGTGTGATCTCGGCTAATTGCAGCCTCCGCCTCCTGGGTTCAAGCGATTCTCCAGCCTCAGCCTCCCAAGTAGCTGGGATT
ACAGGCATCCGCCACCACACCCGGCTAATTTTTTGTATTTTCAGTAGAGACGTGGTTTCACCATGTTGGCCGGGCTGGTCTCGAACTCCT
GACCTCAGATGATCCGCCCGCCTCAGCCTCCCAAAATGCTGGGATTACAGGCGTGAGCCACCGCGTCCAGCCAAGAAAAAAAGTTTTTAA
TGAAAGAAACAGAAACTGATGCCATTATATAATGAACCCTAGTACCCATCACCCAGCTTCAGCAGGTGTTAGTATTTTGTGACTCTTTGA
TTTTTTTGTCTTGGGCCTAGGTGAAATGACAATGGATGCTCTGTTGGCTCGATTGAAACTTCTGAATCCAGATGACCTTAGAGAAGAAAT
CGTCAAAGCCGGATTGAAATGTGGACCCATTACATCAACTACAAGGTTCATTTTTGAGAAAAAATTGGCTCAGGCTTTACTGGAGCAAGG
AGGAAGGCTGTCTTCTTTCTACCACCATGAGGCAGGTGTCACAGCTCTCAGCCAGGACCCACAAAGGATTTTGAAGCCAGCTGAAGGGAA
CCCAACTGATCAGGCTGGTTTTTCTGAAGACAGAGATTTTGGTTACAGTGTGGGCCTGAATCCTCCAGAGGAGGAAGCTGTGACATCCAA
GACCTGCTCGGTGCCCCCTAGTGACACCGACACCTACAGAGCTGGAGCGACTGCGTCTAAGGAGCCGCCCCTGTACTATGGGGTGTGTCC
AGTGTATGAGGACGTCCCAGCGAGAAATGAAAGGATCTATGTTTATGAAAATAAAAAGGAAGCATTGCAAGCTGTCAAGATGATCAAAGG
GTCCCGATTTAAAGCTTTTTCTACCAGAGAAGACGCTGAGAAATTTGCTAGAGGAATTTGTGATTATTTCCCTTCTCCAAGCAAAACGTC
CTTACCACTGTCTCCTGTGAAAACAGCTCCACTCTTTAGCAATGACAGGTTGAAAGATGGTTTGTGCTTGTCGGAATCAGAAACAGTCAA
CAAAGAGCGAGCGAACAGTTACAAAAATCCCCGCACGCAGGACCTCACCGCCAAGCTTCGGAAAGCTGTGGAGAAGGGAGAGGAGGACAC
CTTTTCTGACCTTATCTGGAGCAACCCCCGGTATCTGATAGGCTCAGGAGACAACCCCACTATCGTGCAGGAAGGGTGCAGGTACAACGT
GATGCATGTTGCTGCCAAAGAGAACCAGGCTTCCATCTGCCAGCTGACTCTGGACGTCCTGGAGAACCCTGACTTCATGAGGCTGATGTA
CCCTGATGACGACGAGGCCATGCTGCAGAAGCGTATCCGTTACGTGGTGGACCTGTACCTCAACACCCCCGACAAGATGACTGAGGCTGA
TGTGAATCCAAAGGCCTATCCCCTTGCCGATGCCCACCTCACCAAGAAGCTACTGGACCTCGTTCAGCAGTCATGTAACTATAAGCAGCT
TCGGAAAGGAGCCAATGAGGCCACCAAAACCCTCAACAGGGGCATCTCTGAGTTCATCGTGATGGCTGCAGACGCCGAGCCACTGGAGAT
CATTCTGCACCTGCCGCTGCTGTGTGAAGACAAGAATGTGCCCTACGTGTTTGTGCGCTCCAAGCAGGCCCTGGGGAGAGCCTGTGGGGT
CTCCAGGCCTGTCATCGCCTGTTCTGTCACCATCAAAGAAGGCTCGCAGCTGAAACAGCAGATCCAATCCATTCAGCAGTCCATTGAAAG
GCTCTTAGTCTAAACCTGTGGCCTCTGCCACGTGCTCCCTGCCAGCTTCCCCCCTGAGGTTGTGTATCATATTATCTGTGTTAGCATGTA
GTATTTTCAGCTACTCTCTATTGTTATAAAATGTAGTACTAAATCTGGTTTCTGGATTTTTGTGTTGTTTTTGTTCTGTTTTACAGGGTT
GCTATCCCCCTTCCTTTCCTCCCTCCCTCTGCCATCCTTCATCCTTTTATCCTCCCTTTTTGGAACAAGTGTTCAGAGCAGACAGAAGCA
GGGTGGTGGCACCGTTGAAAGGCAGAAAGAGCCAGGAGAAAGCTGATGGAGCCAGGACAGAGATCTGGTTCCAGCTTTCAGCCACTAGCT
TCCTGTTGTGTGCGGGGTGTGGTGGAATTAAACAGCATTCATTGTGTGTCCCTGTGCCTGGCACACAGAATCATTCATACGTGTTCAAGT
GATCAAGGGGTTTCATTTGCTCTTGGGGGATTAGGTATCATTTGGGGAGGAAGCATGTGTTCTGTGAGGTTGTTCGGCTATGTCCAAGTG
TCGTTTACTAATGTACCCCTGCTGTTTGCTTTTGGTAATGTGATGTTGATGTTCTCCCCCTACCCACAACCATGCCCTTGAGGGTAGCAG
GGCAGCAGCATACCAAAGAGATGTGCTGCAGGACTCCGGAGGCAGCCTGGGTGGGTGAGCCATGGGGCAGTTGACCTGGGTCTTGAAAGA
GTCGGGAGTGACAAGCTCAGAGAGCATGAACTGATGCTGGCATGAAGGATTCCAGGAAGATCATGGAGACCTGGCTGGTAGCTGTAACAG
AGATGGTGGAGTCCAAGGAAACAGCCTGTCTCTGGTGAATGGGACTTTCTTTGGTGGACACTTGGCACCAGCTCTGAGAGCCCTTCCCCT

>4500_4500_18_ANKLE2-NHP2L1_ANKLE2_chr12_133324418_ENST00000539605_NHP2L1_chr22_42076368_ENST00000401959_length(amino acids)=480AA_BP=353
MGLGEMTMDALLARLKLLNPDDLREEIVKAGLKCGPITSTTRFIFEKKLAQALLEQGGRLSSFYHHEAGVTALSQDPQRILKPAEGNPTD
QAGFSEDRDFGYSVGLNPPEEEAVTSKTCSVPPSDTDTYRAGATASKEPPLYYGVCPVYEDVPARNERIYVYENKKEALQAVKMIKGSRF
KAFSTREDAEKFARGICDYFPSPSKTSLPLSPVKTAPLFSNDRLKDGLCLSESETVNKERANSYKNPRTQDLTAKLRKAVEKGEEDTFSD
LIWSNPRYLIGSGDNPTIVQEGCRYNVMHVAAKENQASICQLTLDVLENPDFMRLMYPDDDEAMLQKRIRYVVDLYLNTPDKMTEADVNP
KAYPLADAHLTKKLLDLVQQSCNYKQLRKGANEATKTLNRGISEFIVMAADAEPLEIILHLPLLCEDKNVPYVFVRSKQALGRACGVSRP

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Fusion Gene PPI Analysis for ANKLE2-SNU13


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
TgeneNHP2L1chr12:133324417chr22:42076368ENST000002159560336_481.0129.0U4 snRNA and U4atac snRNA
TgeneNHP2L1chr12:133324417chr22:42076368ENST000003552570336_481.0129.0U4 snRNA and U4atac snRNA
TgeneNHP2L1chr12:133324417chr22:42076368ENST000004019591436_481.0129.0U4 snRNA and U4atac snRNA
TgeneNHP2L1chr12:133324418chr22:42076368ENST000002159560336_481.0129.0U4 snRNA and U4atac snRNA
TgeneNHP2L1chr12:133324418chr22:42076368ENST000003552570336_481.0129.0U4 snRNA and U4atac snRNA
TgeneNHP2L1chr12:133324418chr22:42076368ENST000004019591436_481.0129.0U4 snRNA and U4atac snRNA


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ANKLE2-SNU13


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ANKLE2-SNU13


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneANKLE2C3711387Autosomal Recessive Primary Microcephaly1ORPHANET
HgeneANKLE2C4225249MICROCEPHALY 16, PRIMARY, AUTOSOMAL RECESSIVE1CTD_human;GENOMICS_ENGLAND;UNIPROT