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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:LRCH1-SPG20 (FusionGDB2 ID:HG23143TG23111)

Fusion Gene Summary for LRCH1-SPG20

check button Fusion gene summary
Fusion gene informationFusion gene name: LRCH1-SPG20
Fusion gene ID: hg23143tg23111
HgeneTgene
Gene symbol

LRCH1

SPG20

Gene ID

23143

23111

Gene nameleucine rich repeats and calponin homology domain containing 1spartin
SynonymsCHDC1|NP81SPG20|TAHCCP1
Cytomap('LRCH1')('SPG20')

13q14.13-q14.2

13q13.3

Type of geneprotein-codingprotein-coding
Descriptionleucine-rich repeat and calponin homology domain-containing protein 1leucine-rich repeats and calponin homology (CH) domain containing 1neuronal protein 81spartinspastic paraplegia 20 (Troyer syndrome)trans-activated by hepatitis C virus core protein 1
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000311191, ENST00000389797, 
ENST00000389798, 
Fusion gene scores* DoF score12 X 7 X 5=4204 X 4 X 4=64
# samples 134
** MAII scorelog2(13/420*10)=-1.69187770463767
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(4/64*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: LRCH1 [Title/Abstract] AND SPG20 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointLRCH1(47127838)-SPG20(36878769), # samples:2
Anticipated loss of major functional domain due to fusion event.LRCH1-SPG20 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
LRCH1-SPG20 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
LRCH1-SPG20 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
LRCH1-SPG20 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
LRCH1-SPG20 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneLRCH1

GO:0034260

negative regulation of GTPase activity

28028151


check buttonFusion gene breakpoints across LRCH1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across SPG20 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4READTCGA-AG-3594LRCH1chr13

47127838

+SPG20chr13

36878769

-


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Fusion Gene ORF analysis for LRCH1-SPG20

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000311191ENST00000495510LRCH1chr13

47127838

+SPG20chr13

36878769

-
5CDS-intronENST00000389797ENST00000495510LRCH1chr13

47127838

+SPG20chr13

36878769

-
5CDS-intronENST00000389798ENST00000495510LRCH1chr13

47127838

+SPG20chr13

36878769

-
Frame-shiftENST00000311191ENST00000438666LRCH1chr13

47127838

+SPG20chr13

36878769

-
Frame-shiftENST00000311191ENST00000451493LRCH1chr13

47127838

+SPG20chr13

36878769

-
Frame-shiftENST00000311191ENST00000494062LRCH1chr13

47127838

+SPG20chr13

36878769

-
Frame-shiftENST00000389797ENST00000438666LRCH1chr13

47127838

+SPG20chr13

36878769

-
Frame-shiftENST00000389797ENST00000451493LRCH1chr13

47127838

+SPG20chr13

36878769

-
Frame-shiftENST00000389797ENST00000494062LRCH1chr13

47127838

+SPG20chr13

36878769

-
Frame-shiftENST00000389798ENST00000438666LRCH1chr13

47127838

+SPG20chr13

36878769

-
Frame-shiftENST00000389798ENST00000451493LRCH1chr13

47127838

+SPG20chr13

36878769

-
Frame-shiftENST00000389798ENST00000494062LRCH1chr13

47127838

+SPG20chr13

36878769

-
In-frameENST00000311191ENST00000355182LRCH1chr13

47127838

+SPG20chr13

36878769

-
In-frameENST00000389797ENST00000355182LRCH1chr13

47127838

+SPG20chr13

36878769

-
In-frameENST00000389798ENST00000355182LRCH1chr13

47127838

+SPG20chr13

36878769

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000311191LRCH1chr1347127838+ENST00000355182SPG20chr1336878769-352953655234172
ENST00000389798LRCH1chr1347127838+ENST00000355182SPG20chr1336878769-34975045202172
ENST00000389797LRCH1chr1347127838+ENST00000355182SPG20chr1336878769-34374444602153

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000311191ENST00000355182LRCH1chr1347127838+SPG20chr1336878769-0.53758540.46241462
ENST00000389798ENST00000355182LRCH1chr1347127838+SPG20chr1336878769-0.532945160.46705484
ENST00000389797ENST00000355182LRCH1chr1347127838+SPG20chr1336878769-0.531826730.4681733

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Fusion Genomic Features for LRCH1-SPG20


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for LRCH1-SPG20


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr13:47127838/chr13:36878769)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneLRCH1chr13:47127838chr13:36878769ENST00000311191+11921_36102697.0Compositional biasNote=His-rich
HgeneLRCH1chr13:47127838chr13:36878769ENST00000311191+11937_54102697.0Compositional biasNote=Gly-rich
HgeneLRCH1chr13:47127838chr13:36878769ENST00000389797+12021_36102764.0Compositional biasNote=His-rich
HgeneLRCH1chr13:47127838chr13:36878769ENST00000389797+12037_54102764.0Compositional biasNote=Gly-rich
HgeneLRCH1chr13:47127838chr13:36878769ENST00000389798+11921_36102729.0Compositional biasNote=His-rich
HgeneLRCH1chr13:47127838chr13:36878769ENST00000389798+11937_54102729.0Compositional biasNote=Gly-rich

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneLRCH1chr13:47127838chr13:36878769ENST00000311191+119576_692102697.0DomainCalponin-homology (CH)
HgeneLRCH1chr13:47127838chr13:36878769ENST00000389797+120576_692102764.0DomainCalponin-homology (CH)
HgeneLRCH1chr13:47127838chr13:36878769ENST00000389798+119576_692102729.0DomainCalponin-homology (CH)
HgeneLRCH1chr13:47127838chr13:36878769ENST00000311191+119121_143102697.0RepeatNote=LRR 2
HgeneLRCH1chr13:47127838chr13:36878769ENST00000311191+119144_166102697.0RepeatNote=LRR 3
HgeneLRCH1chr13:47127838chr13:36878769ENST00000311191+119167_187102697.0RepeatNote=LRR 4
HgeneLRCH1chr13:47127838chr13:36878769ENST00000311191+119189_210102697.0RepeatNote=LRR 5
HgeneLRCH1chr13:47127838chr13:36878769ENST00000311191+119212_234102697.0RepeatNote=LRR 6
HgeneLRCH1chr13:47127838chr13:36878769ENST00000311191+119235_255102697.0RepeatNote=LRR 7
HgeneLRCH1chr13:47127838chr13:36878769ENST00000311191+119257_278102697.0RepeatNote=LRR 8
HgeneLRCH1chr13:47127838chr13:36878769ENST00000311191+119283_304102697.0RepeatNote=LRR 9
HgeneLRCH1chr13:47127838chr13:36878769ENST00000311191+11998_119102697.0RepeatNote=LRR 1
HgeneLRCH1chr13:47127838chr13:36878769ENST00000389797+120121_143102764.0RepeatNote=LRR 2
HgeneLRCH1chr13:47127838chr13:36878769ENST00000389797+120144_166102764.0RepeatNote=LRR 3
HgeneLRCH1chr13:47127838chr13:36878769ENST00000389797+120167_187102764.0RepeatNote=LRR 4
HgeneLRCH1chr13:47127838chr13:36878769ENST00000389797+120189_210102764.0RepeatNote=LRR 5
HgeneLRCH1chr13:47127838chr13:36878769ENST00000389797+120212_234102764.0RepeatNote=LRR 6
HgeneLRCH1chr13:47127838chr13:36878769ENST00000389797+120235_255102764.0RepeatNote=LRR 7
HgeneLRCH1chr13:47127838chr13:36878769ENST00000389797+120257_278102764.0RepeatNote=LRR 8
HgeneLRCH1chr13:47127838chr13:36878769ENST00000389797+120283_304102764.0RepeatNote=LRR 9
HgeneLRCH1chr13:47127838chr13:36878769ENST00000389797+12098_119102764.0RepeatNote=LRR 1
HgeneLRCH1chr13:47127838chr13:36878769ENST00000389798+119121_143102729.0RepeatNote=LRR 2
HgeneLRCH1chr13:47127838chr13:36878769ENST00000389798+119144_166102729.0RepeatNote=LRR 3
HgeneLRCH1chr13:47127838chr13:36878769ENST00000389798+119167_187102729.0RepeatNote=LRR 4
HgeneLRCH1chr13:47127838chr13:36878769ENST00000389798+119189_210102729.0RepeatNote=LRR 5
HgeneLRCH1chr13:47127838chr13:36878769ENST00000389798+119212_234102729.0RepeatNote=LRR 6
HgeneLRCH1chr13:47127838chr13:36878769ENST00000389798+119235_255102729.0RepeatNote=LRR 7
HgeneLRCH1chr13:47127838chr13:36878769ENST00000389798+119257_278102729.0RepeatNote=LRR 8
HgeneLRCH1chr13:47127838chr13:36878769ENST00000389798+119283_304102729.0RepeatNote=LRR 9
HgeneLRCH1chr13:47127838chr13:36878769ENST00000389798+11998_119102729.0RepeatNote=LRR 1
TgeneSPG20chr13:47127838chr13:36878769ENST000003551827916_94577667.0DomainNote=MIT
TgeneSPG20chr13:47127838chr13:36878769ENST0000035518279427_611577667.0DomainSenescence
TgeneSPG20chr13:47127838chr13:36878769ENST000004386667916_94577667.0DomainNote=MIT
TgeneSPG20chr13:47127838chr13:36878769ENST0000043866679427_611577667.0DomainSenescence
TgeneSPG20chr13:47127838chr13:36878769ENST000004514937916_94577667.0DomainNote=MIT
TgeneSPG20chr13:47127838chr13:36878769ENST0000045149379427_611577667.0DomainSenescence
TgeneSPG20chr13:47127838chr13:36878769ENST0000049406281016_94577667.0DomainNote=MIT
TgeneSPG20chr13:47127838chr13:36878769ENST00000494062810427_611577667.0DomainSenescence


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Fusion Gene Sequence for LRCH1-SPG20


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>49643_49643_1_LRCH1-SPG20_LRCH1_chr13_47127838_ENST00000311191_SPG20_chr13_36878769_ENST00000355182_length(transcript)=3529nt_BP=536nt
CCGCAGTCCTTAGCTTCCCGGGGACAGGAAACCTTCAAGACCGAGCTGCCACGGCCGCCTCCCCGCCCGCCCCCCATTCTACGCGCCTGC
CCACACCCTCCTCCCCTCCTTCCAGCGCCTTTCGGTGGAGCACTGCGGCACTCAGCCCGAGCTGCCGTTTTCCCCTCGCGGGGAACGCTG
TGACCCCCCCGCAGGAGCGGCGGGGCGGGGTGGGGGGGCCCGGGAGAAGATGGCGACGCCGGGAAGCGAACCCCAACCTTTCGTCCCGGC
CCTTTCGGTAGCTACTCTGCACCCACTTCATCATCCCCACCACCACCACCACCACCATCAGCACCACGGAGGAACCGGCGCCCCCGGCGG
GGCGGGTGGTGGCGGCGGTGGCAGCGGGGGCTTCAACCTGCCCTTGAACCGGGGTCTGGAGCGCGCGCTTGAGGAGGCGGCCAACTCCGG
GGGGCTGAACCTGAGCGCCAGGAAATTGAAGGAATTTCCCCGTACCGCAGCCCCCGGGCACGACCTCTCGGACACGGTGCAGGCAGATAC
GGATATAATGCAGGAGAAGCTACCCACCATGCGGTGGATTCTGCGGTCAATGTTGGCGTAACTGCCTACAATATTAACAACATTGGTATC
AAAGCAATGGTGAAGAAAACTGCAACACAAACAGGACACACTCTCCTTGAGGACTATCAGATAGTTGATAATTCTCAGAGGGAAAATCAA
GAAGGAGCAGCAAATGTCAACGTGAGAGGGGAGAAGGATGAGCAGACGAAGGAAGTAAAGGAGGCAAAGAAGAAAGATAAATGATGAAGT
GCTGGGAATCACTTATACCAAAGCCTTATGAAATGGATGAAATTTTGTTAAATAGGCAAATGTGGAATTCCTCACAGATTAACCAGTATT
TTTTAAATGTATTCATTCCTACAAATTAACTTTCATAAATTTTATGGCATGTCTTCTATTTAAAAGGAAAAGAATAAGTATTCTTGCATC
TGGCCTTAGAAATGTGAAGTTATATTCTCAAGTTTATTTTTTTCCAAGTGTAGCTAAAATATTTTTGCAGGTAAAATAAAGCTGATAGTA
CATGTGTTGTTCAAACCTTGTTAAACCTAATATTGAACTATTTTTATATCTGCTGTCTTTCAGAAGGCAAATAGGAAACTATATATTTGC
TTAAAAATTGGCATTTAGTAACCTTAATTCTTTTTATAGAAGGAATGACTTAAAGTATTGTCCCCTCTTTTTGCACTAATTGTGGATTTT
TTTAGATGCTTCTCAAAATTTTCAGTGTGTAAGCTAAACAAAAACTAAAACTAAGAATTCTCAAAAAAACTTGTTCAAAACAGGGAAAGA
CTGATGAAAAGTAAAATGGACTACTTTTGTAACTTACCTGTTTGTTAGGAAATGGAATGGTCTCTTTGATTTAAAATAAATAAAAATAGA
TTATTACGTCTTTTGTATTGAGACTGTATTGTTATGAGCCTAGGAAATTTGGGAACATGATTGTATTGTATTAAAATTCGAAGTGATTAT
TATCAGCTTAATTGGATTAAAAAAGTACTTCAAGAAATTATTTTATCATATCTGCTTCTGTTTTTCCAAAAGGTTAAAACTTGTAAAAAA
AATATATATAAACAATTGAGTTTACTAATGGTAAACATTTTTATTCTGGGATTCGGTCATTGGAATTTATATTAAAAGACAAGTTATTAA
AAAGGAAAGGTTCTATTCATAATCAGGGTAAAGAATATGAAAACCTTAGACGTAATCCATGGTGGATAGGCATTATGGTTTCCACTTTGG
CAGAAGGCAGACTATTCACAGCCCTATTTACTTACATAGGCTAAAAAACTATGTAACTAAATACCTAATGGTATTTAATTTTTGTTTATT
GAATTTAAGAGATTGGTATTAGTTTTCATAGCTGTAGTCCATTCTAATAATTTCTGATCTTCTAGTGGCTACTTAATTAGACATTATTTG
AAGCTGTCTGAAGAATGCACTTTATGAATTAAAAAACTGAATTGCCTGACCTCGTTATCACATGAGCTTATATTTTGGGAACACATAGAA
CTGATGGAGGCTTTTCCTAAGGCCAAGGATAATGTACTAGTTGTTAAAATGGAAATAAAAGTGAAGTGGTAAATAGCTTACAGACAGTCT
ATGCTTTGTTTAAGAAATGGAATGGCACTTCATATATTCTCATTTGTGGGAGCTAAAAATTACAATAATCAAACTTAAGGAGATAGAGAG
TAGAATGATGGTTACCAGAGGCTGGGAGGCATTGAAGGGATGGGGAGGGAAGTGAGGTTGATTAATGGGTACGAAAATATAGTTAGAACG
AATTTGTTGTAGTATTTGATAGCCCAACAGGGTGACTACAGTCAACAATAACTTTATACATTTAAAAATAAAAGAGTGTAATTGGGACGT
TTGTAACACAAATGAATGCTTGAAGCAGTAGATACACCCTGATGTAATTATTATAAATCGCATACCTGTATCAAAATATCTCATGTATCC
CATAAATATATACACCTACCATGTACCCATAAAAATTTAAAAAGAAATGGAATGGCAAATAATGGAACATAAACTTTAAACAGTTAGCTT
TGACCAGAGGTCAGCAAATATCCTCCATGGGCTAAATCCAGATGTCCACCTGTTTTCATAAATAACGTTTTATTGGAGCATAGCTGTACC
CATTTGTTTACATATTGGCTATGGCTGCTGTCTAGTTCAACGTGAGAGTTGAATAGTTGCATCAGAGAGTATATGGTCCACAAGCCTAAC
TTATTCACTCTCTGGCCCTTTGCAGAAAAAGTGTGCTGCCTTAGTCTATAGAAAATGGACTTTTCCCACCATTCACTGACTCATTAGGAG
ATAGGCATCTTCTAAAGATTTTTTTTATATTGTGTAATGATTGATATATAGATAAAATTATATATTACTTGTAAGGTATGATGAATAACA
ACACTTAAAAACTCATCACACCTAAAGACATGGAAAGCTGCCAATTACCTATATGTATGTTCTTCCTATTTTCTTACCTCTTTCCCCATG
TCATTTTTTATTGTTCCTTGCCATTTTTTAATCACACATGTATGTTCTCCAAACATACTGTTTCATTTTTTGAAGCTTTCTACATATAGT
GTCTGAATGTGAAGTCTTACTCAACTTGCTTTTTTGAGTTTATGTTTAAAATTCATTCTTGCGCTTATATGCATGGATGGTTTACTTGCT
CTATAGTATTCTGTGTGAGTATACCACAATTTAAGTGTTCATTTTCCTATCAGTTGACATTTGTTTTTAGTTTTTGTTGGTAGAAACAGT
ACACTCAAAACATCCTTGACTGTCCCCTGGTACACATATGCAAGAGACTTTATGCGTAAGAGTGGAGTTGTTGGCTTGTCAAGTTTTGCA
AAATAATGCCAGGTATTTTCCAAAATGATGATATTCTCTTGAGTATTACTTCCCTTTGCAATGTTTTTATTGTTAATGTAGCATATATAA

>49643_49643_1_LRCH1-SPG20_LRCH1_chr13_47127838_ENST00000311191_SPG20_chr13_36878769_ENST00000355182_length(amino acids)=172AA_BP=
MHYIRICLHRVREVVPGGCGTGKFLQFPGAQVQPPGVGRLLKRALQTPVQGQVEAPAATAATTRPAGGAGSSVVLMVVVVVVGMMKWVQS

--------------------------------------------------------------
>49643_49643_2_LRCH1-SPG20_LRCH1_chr13_47127838_ENST00000389797_SPG20_chr13_36878769_ENST00000355182_length(transcript)=3437nt_BP=444nt
ACACCCTCCTCCCCTCCTTCCAGCGCCTTTCGGTGGAGCACTGCGGCACTCAGCCCGAGCTGCCGTTTTCCCCTCGCGGGGAACGCTGTG
ACCCCCCCGCAGGAGCGGCGGGGCGGGGTGGGGGGGCCCGGGAGAAGATGGCGACGCCGGGAAGCGAACCCCAACCTTTCGTCCCGGCCC
TTTCGGTAGCTACTCTGCACCCACTTCATCATCCCCACCACCACCACCACCACCATCAGCACCACGGAGGAACCGGCGCCCCCGGCGGGG
CGGGTGGTGGCGGCGGTGGCAGCGGGGGCTTCAACCTGCCCTTGAACCGGGGTCTGGAGCGCGCGCTTGAGGAGGCGGCCAACTCCGGGG
GGCTGAACCTGAGCGCCAGGAAATTGAAGGAATTTCCCCGTACCGCAGCCCCCGGGCACGACCTCTCGGACACGGTGCAGGCAGATACGG
ATATAATGCAGGAGAAGCTACCCACCATGCGGTGGATTCTGCGGTCAATGTTGGCGTAACTGCCTACAATATTAACAACATTGGTATCAA
AGCAATGGTGAAGAAAACTGCAACACAAACAGGACACACTCTCCTTGAGGACTATCAGATAGTTGATAATTCTCAGAGGGAAAATCAAGA
AGGAGCAGCAAATGTCAACGTGAGAGGGGAGAAGGATGAGCAGACGAAGGAAGTAAAGGAGGCAAAGAAGAAAGATAAATGATGAAGTGC
TGGGAATCACTTATACCAAAGCCTTATGAAATGGATGAAATTTTGTTAAATAGGCAAATGTGGAATTCCTCACAGATTAACCAGTATTTT
TTAAATGTATTCATTCCTACAAATTAACTTTCATAAATTTTATGGCATGTCTTCTATTTAAAAGGAAAAGAATAAGTATTCTTGCATCTG
GCCTTAGAAATGTGAAGTTATATTCTCAAGTTTATTTTTTTCCAAGTGTAGCTAAAATATTTTTGCAGGTAAAATAAAGCTGATAGTACA
TGTGTTGTTCAAACCTTGTTAAACCTAATATTGAACTATTTTTATATCTGCTGTCTTTCAGAAGGCAAATAGGAAACTATATATTTGCTT
AAAAATTGGCATTTAGTAACCTTAATTCTTTTTATAGAAGGAATGACTTAAAGTATTGTCCCCTCTTTTTGCACTAATTGTGGATTTTTT
TAGATGCTTCTCAAAATTTTCAGTGTGTAAGCTAAACAAAAACTAAAACTAAGAATTCTCAAAAAAACTTGTTCAAAACAGGGAAAGACT
GATGAAAAGTAAAATGGACTACTTTTGTAACTTACCTGTTTGTTAGGAAATGGAATGGTCTCTTTGATTTAAAATAAATAAAAATAGATT
ATTACGTCTTTTGTATTGAGACTGTATTGTTATGAGCCTAGGAAATTTGGGAACATGATTGTATTGTATTAAAATTCGAAGTGATTATTA
TCAGCTTAATTGGATTAAAAAAGTACTTCAAGAAATTATTTTATCATATCTGCTTCTGTTTTTCCAAAAGGTTAAAACTTGTAAAAAAAA
TATATATAAACAATTGAGTTTACTAATGGTAAACATTTTTATTCTGGGATTCGGTCATTGGAATTTATATTAAAAGACAAGTTATTAAAA
AGGAAAGGTTCTATTCATAATCAGGGTAAAGAATATGAAAACCTTAGACGTAATCCATGGTGGATAGGCATTATGGTTTCCACTTTGGCA
GAAGGCAGACTATTCACAGCCCTATTTACTTACATAGGCTAAAAAACTATGTAACTAAATACCTAATGGTATTTAATTTTTGTTTATTGA
ATTTAAGAGATTGGTATTAGTTTTCATAGCTGTAGTCCATTCTAATAATTTCTGATCTTCTAGTGGCTACTTAATTAGACATTATTTGAA
GCTGTCTGAAGAATGCACTTTATGAATTAAAAAACTGAATTGCCTGACCTCGTTATCACATGAGCTTATATTTTGGGAACACATAGAACT
GATGGAGGCTTTTCCTAAGGCCAAGGATAATGTACTAGTTGTTAAAATGGAAATAAAAGTGAAGTGGTAAATAGCTTACAGACAGTCTAT
GCTTTGTTTAAGAAATGGAATGGCACTTCATATATTCTCATTTGTGGGAGCTAAAAATTACAATAATCAAACTTAAGGAGATAGAGAGTA
GAATGATGGTTACCAGAGGCTGGGAGGCATTGAAGGGATGGGGAGGGAAGTGAGGTTGATTAATGGGTACGAAAATATAGTTAGAACGAA
TTTGTTGTAGTATTTGATAGCCCAACAGGGTGACTACAGTCAACAATAACTTTATACATTTAAAAATAAAAGAGTGTAATTGGGACGTTT
GTAACACAAATGAATGCTTGAAGCAGTAGATACACCCTGATGTAATTATTATAAATCGCATACCTGTATCAAAATATCTCATGTATCCCA
TAAATATATACACCTACCATGTACCCATAAAAATTTAAAAAGAAATGGAATGGCAAATAATGGAACATAAACTTTAAACAGTTAGCTTTG
ACCAGAGGTCAGCAAATATCCTCCATGGGCTAAATCCAGATGTCCACCTGTTTTCATAAATAACGTTTTATTGGAGCATAGCTGTACCCA
TTTGTTTACATATTGGCTATGGCTGCTGTCTAGTTCAACGTGAGAGTTGAATAGTTGCATCAGAGAGTATATGGTCCACAAGCCTAACTT
ATTCACTCTCTGGCCCTTTGCAGAAAAAGTGTGCTGCCTTAGTCTATAGAAAATGGACTTTTCCCACCATTCACTGACTCATTAGGAGAT
AGGCATCTTCTAAAGATTTTTTTTATATTGTGTAATGATTGATATATAGATAAAATTATATATTACTTGTAAGGTATGATGAATAACAAC
ACTTAAAAACTCATCACACCTAAAGACATGGAAAGCTGCCAATTACCTATATGTATGTTCTTCCTATTTTCTTACCTCTTTCCCCATGTC
ATTTTTTATTGTTCCTTGCCATTTTTTAATCACACATGTATGTTCTCCAAACATACTGTTTCATTTTTTGAAGCTTTCTACATATAGTGT
CTGAATGTGAAGTCTTACTCAACTTGCTTTTTTGAGTTTATGTTTAAAATTCATTCTTGCGCTTATATGCATGGATGGTTTACTTGCTCT
ATAGTATTCTGTGTGAGTATACCACAATTTAAGTGTTCATTTTCCTATCAGTTGACATTTGTTTTTAGTTTTTGTTGGTAGAAACAGTAC
ACTCAAAACATCCTTGACTGTCCCCTGGTACACATATGCAAGAGACTTTATGCGTAAGAGTGGAGTTGTTGGCTTGTCAAGTTTTGCAAA
ATAATGCCAGGTATTTTCCAAAATGATGATATTCTCTTGAGTATTACTTCCCTTTGCAATGTTTTTATTGTTAATGTAGCATATATAAAA

>49643_49643_2_LRCH1-SPG20_LRCH1_chr13_47127838_ENST00000389797_SPG20_chr13_36878769_ENST00000355182_length(amino acids)=153AA_BP=
MHYIRICLHRVREVVPGGCGTGKFLQFPGAQVQPPGVGRLLKRALQTPVQGQVEAPAATAATTRPAGGAGSSVVLMVVVVVVGMMKWVQS

--------------------------------------------------------------
>49643_49643_3_LRCH1-SPG20_LRCH1_chr13_47127838_ENST00000389798_SPG20_chr13_36878769_ENST00000355182_length(transcript)=3497nt_BP=504nt
CTTCAAGACCGAGCTGCCACGGCCGCCTCCCCGCCCGCCCCCCATTCTACGCGCCTGCCCACACCCTCCTCCCCTCCTTCCAGCGCCTTT
CGGTGGAGCACTGCGGCACTCAGCCCGAGCTGCCGTTTTCCCCTCGCGGGGAACGCTGTGACCCCCCCGCAGGAGCGGCGGGGCGGGGTG
GGGGGGCCCGGGAGAAGATGGCGACGCCGGGAAGCGAACCCCAACCTTTCGTCCCGGCCCTTTCGGTAGCTACTCTGCACCCACTTCATC
ATCCCCACCACCACCACCACCACCATCAGCACCACGGAGGAACCGGCGCCCCCGGCGGGGCGGGTGGTGGCGGCGGTGGCAGCGGGGGCT
TCAACCTGCCCTTGAACCGGGGTCTGGAGCGCGCGCTTGAGGAGGCGGCCAACTCCGGGGGGCTGAACCTGAGCGCCAGGAAATTGAAGG
AATTTCCCCGTACCGCAGCCCCCGGGCACGACCTCTCGGACACGGTGCAGGCAGATACGGATATAATGCAGGAGAAGCTACCCACCATGC
GGTGGATTCTGCGGTCAATGTTGGCGTAACTGCCTACAATATTAACAACATTGGTATCAAAGCAATGGTGAAGAAAACTGCAACACAAAC
AGGACACACTCTCCTTGAGGACTATCAGATAGTTGATAATTCTCAGAGGGAAAATCAAGAAGGAGCAGCAAATGTCAACGTGAGAGGGGA
GAAGGATGAGCAGACGAAGGAAGTAAAGGAGGCAAAGAAGAAAGATAAATGATGAAGTGCTGGGAATCACTTATACCAAAGCCTTATGAA
ATGGATGAAATTTTGTTAAATAGGCAAATGTGGAATTCCTCACAGATTAACCAGTATTTTTTAAATGTATTCATTCCTACAAATTAACTT
TCATAAATTTTATGGCATGTCTTCTATTTAAAAGGAAAAGAATAAGTATTCTTGCATCTGGCCTTAGAAATGTGAAGTTATATTCTCAAG
TTTATTTTTTTCCAAGTGTAGCTAAAATATTTTTGCAGGTAAAATAAAGCTGATAGTACATGTGTTGTTCAAACCTTGTTAAACCTAATA
TTGAACTATTTTTATATCTGCTGTCTTTCAGAAGGCAAATAGGAAACTATATATTTGCTTAAAAATTGGCATTTAGTAACCTTAATTCTT
TTTATAGAAGGAATGACTTAAAGTATTGTCCCCTCTTTTTGCACTAATTGTGGATTTTTTTAGATGCTTCTCAAAATTTTCAGTGTGTAA
GCTAAACAAAAACTAAAACTAAGAATTCTCAAAAAAACTTGTTCAAAACAGGGAAAGACTGATGAAAAGTAAAATGGACTACTTTTGTAA
CTTACCTGTTTGTTAGGAAATGGAATGGTCTCTTTGATTTAAAATAAATAAAAATAGATTATTACGTCTTTTGTATTGAGACTGTATTGT
TATGAGCCTAGGAAATTTGGGAACATGATTGTATTGTATTAAAATTCGAAGTGATTATTATCAGCTTAATTGGATTAAAAAAGTACTTCA
AGAAATTATTTTATCATATCTGCTTCTGTTTTTCCAAAAGGTTAAAACTTGTAAAAAAAATATATATAAACAATTGAGTTTACTAATGGT
AAACATTTTTATTCTGGGATTCGGTCATTGGAATTTATATTAAAAGACAAGTTATTAAAAAGGAAAGGTTCTATTCATAATCAGGGTAAA
GAATATGAAAACCTTAGACGTAATCCATGGTGGATAGGCATTATGGTTTCCACTTTGGCAGAAGGCAGACTATTCACAGCCCTATTTACT
TACATAGGCTAAAAAACTATGTAACTAAATACCTAATGGTATTTAATTTTTGTTTATTGAATTTAAGAGATTGGTATTAGTTTTCATAGC
TGTAGTCCATTCTAATAATTTCTGATCTTCTAGTGGCTACTTAATTAGACATTATTTGAAGCTGTCTGAAGAATGCACTTTATGAATTAA
AAAACTGAATTGCCTGACCTCGTTATCACATGAGCTTATATTTTGGGAACACATAGAACTGATGGAGGCTTTTCCTAAGGCCAAGGATAA
TGTACTAGTTGTTAAAATGGAAATAAAAGTGAAGTGGTAAATAGCTTACAGACAGTCTATGCTTTGTTTAAGAAATGGAATGGCACTTCA
TATATTCTCATTTGTGGGAGCTAAAAATTACAATAATCAAACTTAAGGAGATAGAGAGTAGAATGATGGTTACCAGAGGCTGGGAGGCAT
TGAAGGGATGGGGAGGGAAGTGAGGTTGATTAATGGGTACGAAAATATAGTTAGAACGAATTTGTTGTAGTATTTGATAGCCCAACAGGG
TGACTACAGTCAACAATAACTTTATACATTTAAAAATAAAAGAGTGTAATTGGGACGTTTGTAACACAAATGAATGCTTGAAGCAGTAGA
TACACCCTGATGTAATTATTATAAATCGCATACCTGTATCAAAATATCTCATGTATCCCATAAATATATACACCTACCATGTACCCATAA
AAATTTAAAAAGAAATGGAATGGCAAATAATGGAACATAAACTTTAAACAGTTAGCTTTGACCAGAGGTCAGCAAATATCCTCCATGGGC
TAAATCCAGATGTCCACCTGTTTTCATAAATAACGTTTTATTGGAGCATAGCTGTACCCATTTGTTTACATATTGGCTATGGCTGCTGTC
TAGTTCAACGTGAGAGTTGAATAGTTGCATCAGAGAGTATATGGTCCACAAGCCTAACTTATTCACTCTCTGGCCCTTTGCAGAAAAAGT
GTGCTGCCTTAGTCTATAGAAAATGGACTTTTCCCACCATTCACTGACTCATTAGGAGATAGGCATCTTCTAAAGATTTTTTTTATATTG
TGTAATGATTGATATATAGATAAAATTATATATTACTTGTAAGGTATGATGAATAACAACACTTAAAAACTCATCACACCTAAAGACATG
GAAAGCTGCCAATTACCTATATGTATGTTCTTCCTATTTTCTTACCTCTTTCCCCATGTCATTTTTTATTGTTCCTTGCCATTTTTTAAT
CACACATGTATGTTCTCCAAACATACTGTTTCATTTTTTGAAGCTTTCTACATATAGTGTCTGAATGTGAAGTCTTACTCAACTTGCTTT
TTTGAGTTTATGTTTAAAATTCATTCTTGCGCTTATATGCATGGATGGTTTACTTGCTCTATAGTATTCTGTGTGAGTATACCACAATTT
AAGTGTTCATTTTCCTATCAGTTGACATTTGTTTTTAGTTTTTGTTGGTAGAAACAGTACACTCAAAACATCCTTGACTGTCCCCTGGTA
CACATATGCAAGAGACTTTATGCGTAAGAGTGGAGTTGTTGGCTTGTCAAGTTTTGCAAAATAATGCCAGGTATTTTCCAAAATGATGAT

>49643_49643_3_LRCH1-SPG20_LRCH1_chr13_47127838_ENST00000389798_SPG20_chr13_36878769_ENST00000355182_length(amino acids)=172AA_BP=
MHYIRICLHRVREVVPGGCGTGKFLQFPGAQVQPPGVGRLLKRALQTPVQGQVEAPAATAATTRPAGGAGSSVVLMVVVVVVGMMKWVQS

--------------------------------------------------------------

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Fusion Gene PPI Analysis for LRCH1-SPG20


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for LRCH1-SPG20


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for LRCH1-SPG20


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneLRCH1C0038454Cerebrovascular accident1CTD_human
HgeneLRCH1C0751956Acute Cerebrovascular Accidents1CTD_human