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 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:CIC-FOXO4 (FusionGDB2 ID:HG23152TG4303) |
Fusion Gene Summary for CIC-FOXO4 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: CIC-FOXO4 | Fusion gene ID: hg23152tg4303 | Hgene | Tgene | Gene symbol | CIC | FOXO4 | Gene ID | 23152 | 4303 |
| Gene name | capicua transcriptional repressor | forkhead box O4 | |
| Synonyms | MRD45 | AFX|AFX1|MLLT7 | |
| Cytomap | ('CIC')('FOXO4') 19q13.2 | Xq13.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | protein capicua homolog | forkhead box protein O4fork head domain transcription factor AFX1myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 7 | |
| Modification date | 20200313 | 20200313 | |
| UniProtAcc | Q96RK0 | P98177 | |
| Ensembl transtripts involved in fusion gene | ENST00000160740, ENST00000572681, ENST00000575354, ENST00000575839, | ||
| Fusion gene scores | * DoF score | 13 X 12 X 6=936 | 4 X 4 X 3=48 |
| # samples | 12 | 4 | |
| ** MAII score | log2(12/936*10)=-2.96347412397489 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(4/48*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: CIC [Title/Abstract] AND FOXO4 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | CIC(42798806)-FOXO4(70320706), # samples:1 | ||
| Anticipated loss of major functional domain due to fusion event. | CIC-FOXO4 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF. CIC-FOXO4 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. CIC-FOXO4 seems lost the major protein functional domain in Hgene partner, which is a transcription factor due to the frame-shifted ORF. CIC-FOXO4 seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF. CIC-FOXO4 seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF. CIC-FOXO4 seems lost the major protein functional domain in Tgene partner, which is a transcription factor due to the frame-shifted ORF. CIC-FOXO4 seems lost the major protein functional domain in Tgene partner, which is a tumor suppressor due to the frame-shifted ORF. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | FOXO4 | GO:0006355 | regulation of transcription, DNA-templated | 15126506 |
| Tgene | FOXO4 | GO:0007050 | cell cycle arrest | 10783894 |
| Tgene | FOXO4 | GO:0008285 | negative regulation of cell proliferation | 10783894 |
| Tgene | FOXO4 | GO:0008286 | insulin receptor signaling pathway | 10217147 |
| Tgene | FOXO4 | GO:0016525 | negative regulation of angiogenesis | 12761217 |
| Tgene | FOXO4 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 11689711|15905404 |
| Tgene | FOXO4 | GO:0051151 | negative regulation of smooth muscle cell differentiation | 16054032 |
| Tgene | FOXO4 | GO:0070317 | negative regulation of G0 to G1 transition | 10783894 |
| Tgene | FOXO4 | GO:0071158 | positive regulation of cell cycle arrest | 15905404 |
| Fusion gene information * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerKB3 | . | . | CIC | chr19 | 42798887 | + | FOXO4 | chrX | 70320533 | + |
| ChimerKB3 | . | . | CIC | chr19 | 42799949 | + | FOXO4 | chrX | 70320533 | + |
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Fusion Gene ORF analysis for CIC-FOXO4 |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-3UTR | ENST00000160740 | ENST00000341558 | CIC | chr19 | 42798887 | + | FOXO4 | chrX | 70320533 | + |
| 5CDS-3UTR | ENST00000160740 | ENST00000341558 | CIC | chr19 | 42799949 | + | FOXO4 | chrX | 70320533 | + |
| 5CDS-3UTR | ENST00000160740 | ENST00000466874 | CIC | chr19 | 42798887 | + | FOXO4 | chrX | 70320533 | + |
| 5CDS-3UTR | ENST00000160740 | ENST00000466874 | CIC | chr19 | 42799949 | + | FOXO4 | chrX | 70320533 | + |
| 5CDS-3UTR | ENST00000572681 | ENST00000341558 | CIC | chr19 | 42798887 | + | FOXO4 | chrX | 70320533 | + |
| 5CDS-3UTR | ENST00000572681 | ENST00000341558 | CIC | chr19 | 42799949 | + | FOXO4 | chrX | 70320533 | + |
| 5CDS-3UTR | ENST00000572681 | ENST00000466874 | CIC | chr19 | 42798887 | + | FOXO4 | chrX | 70320533 | + |
| 5CDS-3UTR | ENST00000572681 | ENST00000466874 | CIC | chr19 | 42799949 | + | FOXO4 | chrX | 70320533 | + |
| 5CDS-3UTR | ENST00000575354 | ENST00000341558 | CIC | chr19 | 42798887 | + | FOXO4 | chrX | 70320533 | + |
| 5CDS-3UTR | ENST00000575354 | ENST00000341558 | CIC | chr19 | 42799949 | + | FOXO4 | chrX | 70320533 | + |
| 5CDS-3UTR | ENST00000575354 | ENST00000466874 | CIC | chr19 | 42798887 | + | FOXO4 | chrX | 70320533 | + |
| 5CDS-3UTR | ENST00000575354 | ENST00000466874 | CIC | chr19 | 42799949 | + | FOXO4 | chrX | 70320533 | + |
| Frame-shift | ENST00000160740 | ENST00000374259 | CIC | chr19 | 42798887 | + | FOXO4 | chrX | 70320533 | + |
| Frame-shift | ENST00000160740 | ENST00000374259 | CIC | chr19 | 42799949 | + | FOXO4 | chrX | 70320533 | + |
| Frame-shift | ENST00000572681 | ENST00000374259 | CIC | chr19 | 42798887 | + | FOXO4 | chrX | 70320533 | + |
| Frame-shift | ENST00000572681 | ENST00000374259 | CIC | chr19 | 42799949 | + | FOXO4 | chrX | 70320533 | + |
| Frame-shift | ENST00000575354 | ENST00000374259 | CIC | chr19 | 42798887 | + | FOXO4 | chrX | 70320533 | + |
| In-frame | ENST00000575354 | ENST00000374259 | CIC | chr19 | 42799949 | + | FOXO4 | chrX | 70320533 | + |
| intron-3CDS | ENST00000575839 | ENST00000374259 | CIC | chr19 | 42798887 | + | FOXO4 | chrX | 70320533 | + |
| intron-3CDS | ENST00000575839 | ENST00000374259 | CIC | chr19 | 42799949 | + | FOXO4 | chrX | 70320533 | + |
| intron-3UTR | ENST00000575839 | ENST00000341558 | CIC | chr19 | 42798887 | + | FOXO4 | chrX | 70320533 | + |
| intron-3UTR | ENST00000575839 | ENST00000341558 | CIC | chr19 | 42799949 | + | FOXO4 | chrX | 70320533 | + |
| intron-3UTR | ENST00000575839 | ENST00000466874 | CIC | chr19 | 42798887 | + | FOXO4 | chrX | 70320533 | + |
| intron-3UTR | ENST00000575839 | ENST00000466874 | CIC | chr19 | 42799949 | + | FOXO4 | chrX | 70320533 | + |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000575354 | CIC | chr19 | 42799949 | + | ENST00000374259 | FOXO4 | chrX | 70320533 | + | 7989 | 5473 | 28 | 4866 | 1612 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
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Fusion Genomic Features for CIC-FOXO4 |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
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Fusion Protein Features for CIC-FOXO4 |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:42798806/chrX:70320706) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| CIC | FOXO4 |
| FUNCTION: Transcriptional repressor which plays a role in development of the central nervous system (CNS). In concert with ATXN1 and ATXN1L, involved in brain development. {ECO:0000250|UniProtKB:Q924A2}. | FUNCTION: Transcription factor involved in the regulation of the insulin signaling pathway. Binds to insulin-response elements (IREs) and can activate transcription of IGFBP1. Down-regulates expression of HIF1A and suppresses hypoxia-induced transcriptional activation of HIF1A-modulated genes. Also involved in negative regulation of the cell cycle. Involved in increased proteasome activity in embryonic stem cells (ESCs) by activating expression of PSMD11 in ESCs, leading to enhanced assembly of the 26S proteasome, followed by higher proteasome activity. {ECO:0000269|PubMed:10217147, ECO:0000269|PubMed:10783894, ECO:0000269|PubMed:12761217, ECO:0000269|PubMed:15126506, ECO:0000269|PubMed:16054032, ECO:0000269|PubMed:16964248, ECO:0000269|PubMed:20874444, ECO:0000269|PubMed:22972301}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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Fusion Gene Sequence for CIC-FOXO4 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >16795_16795_1_CIC-FOXO4_CIC_chr19_42799949_ENST00000575354_FOXO4_chrX_70320533_ENST00000374259_length(transcript)=7989nt_BP=5473nt GGAGGTGCGAGCCCCTGCCGGGTCCCCCCTGCGCCGGACCATGTATTCGGCCCACAGGCCCCTGATGCCCGCGTCCAGCGCGGCCTCCCG TGGCCTCGGCATGTTCGTGTGGACGAATGTGGAACCTCGCTCTGTGGCTGTGTTCCCTTGGCACTCCTTAGTCCCCTTCCTGGCACCCAG CCAGCCTGACCCCTCCGTGCAGCCGAGCGAGGCCCAGCAACCTGCCAGCCACCCAGTGGCCTCCAACCAGAGCAAAGAACCTGCTGAGTC GGCAGCTGTTGCTCATGAACGGCCACCAGGTGGGACAGGGAGTGCTGACCCTGAGCGGCCCCCTGGAGCCACATGCCCTGAGAGCCCAGG ACCCGGACCCCCACACCCTTTGGGGGTGGTGGAATCTGGTAAGGGTCCGCCTCCCACCACGGAGGAGGAGGCCTCCGGCCCCCCAGGAGA GCCCCGGCTGGACAGTGAGACAGAGAGTGACCATGATGATGCCTTCCTCTCCATCATGTCTCCTGAGATCCAGTTGCCTCTACCGCCCGG AAAACGTCGGACCCAGTCCCTCAGTGCCCTACCCAAGGAACGGGACTCATCTTCTGAGAAGGATGGACGCAGCCCCAACAAGCGGGAGAA GGACCACATCCGGCGGCCCATGAATGCCTTCATGATCTTCAGCAAGCGGCACCGGGCCCTGGTCCACCAGCGTCATCCCAACCAGGACAA CCGGACCGTCAGCAAGATCCTGGGCGAGTGGTGGTATGCCCTGGGGCCCAAGGAGAAGCAGAAGTACCACGACCTGGCCTTCCAGGTGAA GGAGGCCCACTTCAAGGCCCACCCAGATTGGAAGTGGTGCAACAAGGACCGAAAGAAGTCCAGCTCAGAGGCCAAGCCCACGAGCCTGGG GCTGGCAGGAGGGCACAAGGAGACGCGGGAGCGGAGCATGTCGGAGACGGGCACTGCTGCTGCCCCTGGGGTGTCCTCTGAGCTCCTGTC CGTTGCAGCCCAGACACTCCTGAGCTCAGACACCAAGGCTCCGGGGAGCAGCTCCTGTGGGGCAGAACGGCTACACACAGTTGGGGGACC TGGCTCAGCCCGGCCCCGAGCTTTCTCCCACAGCGGGGTACACAGCCTGGACGGCGGAGAAGTAGACAGTCAGGCGCTACAGGAACTGAC GCAGATGGTGTCTGGCCCTGCATCGTACTCTGGCCCAAAGCCTTCTACCCAGTATGGAGCTCCAGGACCCTTTGCAGCCCCTGGTGAGGG AGGTGCCTTGGCGGCCACTGGGCGGCCCCCGCTGCTGCCCACCCGAGCTTCTCGTTCTCAGCGTGCGGCCAGTGAGGACATGACGAGTGA TGAGGAGCGCATGGTCATCTGTGAGGAGGAAGGGGATGATGATGTCATTGCTGACGATGGCTTCGGCACCACTGACATTGATCTCAAGTG CAAGGAGCGGGTGACCGACAGCGAGAGTGGGGACAGCTCTGGGGAGGACCCAGAGGGCAACAAGGGCTTTGGTCGGAAGGTGTTTTCACC TGTGATCCGTTCCTCCTTTACCCACTGCCGCCCCCCACTGGACCCTGAGCCCCCAGGGCCCCCGGATCCTCCTGTAGCCTTTGGCAAAGG CTATGGTTCCGCCCCATCCTCCTCTGCGTCCTCGCCTGCTTCCTCCTCAGCCTCGGCAGCCACCTCCTTCTCACTGGGCTCAGGAACCTT CAAGGCCCAGGAGTCTGGTCAGGGCAGCACAGCGGGCCCCCTACGGCCCCCACCCCCTGGGGCTGGGGGTCCAGCGACACCTTCCAAGGC AACCCGGTTCCTCCCAATGGATCCTGCCACCTTCCGGCGCAAGAGACCCGAAAGTGTGGGTGGCCTGGAGCCACCAGGCCCCTCAGTCAT CGCGGCCCCTCCCAGCGGAGGAGGAAACATCCTGCAGACACTGGTGCTGCCCCCAAACAAGGAGGAGCAAGAGGGCGGCGGAGCCAGAGT GCCCTCCGCCCCCGCCCCATCACTGGCCTATGGGGCCCCAGCAGCTCCCCTGTCCCGTCCTGCCGCCACCATGGTCACCAATGTGGTGCG GCCTGTCAGCAGCACTCCTGTGCCCATCGCCTCTAAGCCCTTCCCCACCTCTGGCCGGGCTGAGGCGTCTCCAAATGACACAGCAGGTGC CAGGACTGAAATGGGCACTGGGTCTCGGGTGCCTGGGGGCTCCCCGCTGGGTGTCAGCTTAGTGTATTCGGACAAGAAGTCGGCAGCAGC CACCTCACCAGCCCCACACTTGGTGGCTGGACCCCTGCTGGGCACTGTGGGGAAGGCGCCTGCCACTGTCACTAACCTACTGGTGGGCAC CCCGGGGTATGGGGCCCCTGCGCCCCCTGCTGTCCAGTTCATTGCCCAGGGGGCCCCTGGTGGTGGGACCACTGCGGGCTCAGGAGCAGG TGCTGGGAGTGGCCCCAATGGGCCAGTACCCCTGGGCATCCTGCAACCAGGTGCCCTGGGCAAGGCTGGGGGAATCACCCAGGTACAGTA CATCCTGCCCACGCTGCCCCAGCAGCTTCAGGTGGCACCTGCCCCAGCACCAGCCCCTGGGACCAAGGCAGCGGCTCCCAGCGGCCCTGC ACCCACCACCAGCATCCGTTTCACCCTCCCACCGGGCACTTCCACCAACGGCAAAGTCCTGGCTGCCACTGCACCCACTCCTGGCATCCC CATCCTGCAGTCTGTACCCTCCGCCCCACCCCCCAAAGCCCAGTCAGTTTCTCCCGTGCAGGCCCCGCCCCCGGGTGGCTCAGCCCAGCT GCTGCCTGGGAAGGTCCTAGTGCCTCTGGCCGCCCCTAGCATGTCAGTGCGGGGTGGAGGGGCCGGCCAGCCACTGCCACTGGTGAGCCC GCCCTTCTCAGTACCTGTGCAGAATGGTGCCCAGCCCCCCAGCAAGATCATCCAGCTGACCCCGGTGCCTGTGAGCACACCCAGCGGCCT GGTGCCGCCCCTGAGCCCAGCCACACTCCCTGGACCCACCTCTCAGCCTCAGAAGGTCCTGTTGCCCTCCTCCACCAGAATCACCTATGT GCAGTCAGCGGGCGGGCACGCGCTGCCCCTGGGTACCAGCCCTGCGTCCAGCCAGGCTGGAACAGTCACCTCGTACGGGCCCACGAGCTC TGTAGCTCTAGGCTTCACCTCGCTGGGGCCCAGCGGCCCCGCCTTCGTGCAGCCCCTGCTCTCAGCAGGCCAAGCCCCACTGCTGGCTCC CGGTCAGGTGGGCGTGTCACCTGTGCCCAGTCCCCAGCTGCCGCCTGCCTGTGCAGCCCCCGGAGGTCCTGTCATAACAGCATTTTACTC TGGCAGCCCTGCACCCACCTCCTCAGCACCCCTGGCCCAGCCATCCCAGGCCCCCCCAAGCCTGGTCTACACTGTGGCCACCAGCACAAC CCCACCTGCAGCCACCATTCTGCCCAAGGGCCCGCCAGCCCCTGCCACTGCCACCCCAGCCCCGACTAGCCCTTTCCCCAGCGCCACAGC AGGTTCCATGACCTACAGCTTAGTGGCCCCCAAGGCCCAGCGGCCCAGCCCGAAGGCCCCCCAGAAAGTGAAGGCAGCCATCGCCAGCAT TCCCGTGGGGTCCTTTGAGGCAGGTGCCTCTGGGCGGCCTGGCCCTGCACCCCGGCAGCCTCTGGAGCCTGGCCCAGTCCGAGAGCCAAC TGCCCCAGAGTCTGAGCTTGAGGGGCAGCCCACACCACCAGCCCCTCCACCCCTGCCAGAGACCTGGACTCCCACGGCCCGGAGCAGCCC CCCACTGCCCCCACCTGCTGAGGAGCGGACCAGCGCCAAGGGCCCTGAGACCATGGCCAGCAAATTCCCCAGCTCATCTTCAGACTGGCG CGTCCCTGGGCAGGGCCTGGAGAATCGTGGGGAGCCTCCCACTCCTCCCAGCCCGGCCCCAGCTCCAGCTGTAGCCCCTGGTGGCAGCAG CGAGAGCAGCAGTGGGCGGGCAGCCGGGGACACCCCGGAGCGCAAGGAGGCGGCTGGTACTGGCAAGAAGGTGAAGGTGCGGCCCCCGCC CCTGAAGAAGACCTTTGACTCTGTGGACAACAGGGTCCTGTCAGAAGTGGACTTCGAAGAGCGCTTTGCTGAGTTGCCTGAGTTTCGGCC TGAGGAGGTGCTGCCCTCCCCCACCCTGCAGTCTCTGGCCACCTCACCCCGGGCCATCCTGGGCTCTTACCGCAAGAAGAGGAAGAACTC CACGGACCTGGATTCAGCACCCGAGGACCCCACCTCGCCCAAGCGCAAGATGAGAAGACGCTCCAGCTGCAGCTCGGAGCCCAACACCCC CAAGAGTGCCAAGTGCGAGGGGGACATCTTCACCTTTGACCGTACAGGTACAGAAGCCGAGGACGTGCTTGGGGAGCTAGAGTATGACAA GGTGCCATACTCCTCCCTGCGGCGCACCCTGGACCAGCGCCGGGCCCTGGTCATGCAGCTCTTTCAGGACCATGGCTTCTTCCCGTCAGC CCAGGCCACAGCCGCCTTCCAGGCCCGCTATGCAGACATCTTTCCCTCCAAGGTTTGTCTGCAGTTGAAGATCCGTGAGGTGCGCCAGAA GATCATGCAGGCTGCCACTCCCACGGAGCAGCCCCCTGGAGCTGAGGCTCCTCTCCCTGTACCGCCCCCCACTGGCACCGCTGCTGCCCC TGCCCCCACTCCCAGCCCCGCAGGGGGCCCTGACCCCACCTCACCCAGCTCGGACTCTGGCACGGCCCAGGCTGCCCCGCCACTGCCTCC ACCCCCAGAGTCGGGGCCTGGACAGCCTGGCTGGGAGGGGGCTCCCCAGCCCTCCCCCCCACCCCCAGGTCCCTCCACAGCTGCCACAGG CAGGTGAGGGACCCCTGAGAAGATGCCAGGACTTATAGTACCCCCTCAGGACATGGACAGTATGTGGGGGCAGGAAGGTTATCTCCTCCC GGGTAAAGCCATTTCGTCCTCTCCAGTTTGGGGCGGAATGAGGCCTGCTCCTCTTGTAAATACCCCCTTCCCTCGAAGCTCCCTCCCGGT GCTGGGGGGCAGCTGAGGGGCTGCAGGGGCAGTCTCCCTCCTCCAAGCCCCTGTACATAACCTGGAGCGTGTGACCTTCAGAGCTTTTCA CTTTATGCAAAATGGCTCCTGTGAGGGCTGCAAGCTGGAGGGTGGTGCAGGCCTTGGGCCACAGGGAGGCGCCTGTGGAATAGGGGGAGT TCATGCACCCCTTTTTTCCCCAGAGGGGCTGGACTCAGGTTAGTTTGGGGGTGGGGGCTCCTGCACTTTGCCACAGGCACGGGGAGGGTT TTCTCCTCACCCCCTCTGCCCTCCCAACTTGGGTTGTACTTTCTAAGAAGGTGATTCCCCCTGCCCTTGCCCCCTTCCCCAGAACAAAAC ATGTTGATCATGTGCAATATTTCTTACTGTGCCGAGAAGCCGCAATGAGCGAGATTAAAGCTGTTTAACACACAACTCGATCCGCCACAA CCTGTCCCTGCACAGCAAGTTCATCAAGGTTCACAACGAGGCCACCGGCAAAAGCTCTTGGTGGATGCTGAACCCTGAGGGAGGCAAGAG CGGCAAAGCCCCCCGCCGCCGGGCCGCCTCCATGGATAGCAGCAGCAAGCTGCTCCGGGGCCGCAGTAAAGCCCCCAAGAAGAAACCATC TGTGCTGCCAGCTCCACCCGAAGGTGCCACTCCAACGAGCCCTGTCGGCCACTTTGCCAAGTGGTCAGGCAGCCCTTGCTCTCGAAACCG TGAAGAAGCCGATATGTGGACCACCTTCCGTCCACGAAGCAGTTCAAATGCCAGCAGTGTCAGCACCCGGCTGTCCCCCTTGAGGCCAGA GTCTGAGGTGCTGGCGGAGGAAATACCAGCTTCAGTCAGCAGTTATGCAGGGGGTGTCCCTCCCACCCTCAATGAAGGTCTAGAGCTGTT AGATGGGCTCAATCTCACCTCTTCCCATTCCCTGCTATCTCGGAGTGGTCTCTCTGGCTTCTCTTTGCAGCATCCTGGGGTTACCGGCCC CTTACACACCTACAGCAGCTCCCTTTTCAGCCCAGCAGAGGGGCCCCTGTCAGCAGGAGAAGGGTGCTTCTCCAGCTCCCAGGCTCTGGA GGCCCTGCTCACCTCTGATACGCCACCACCCCCTGCTGACGTCCTCATGACCCAGGTAGATCCCATTCTGTCCCAGGCTCCGACTCTTCT GTTGCTGGGGGGGCTTCCTTCCTCCAGTAAGCTGGCCACGGGCGTCGGCCTGTGTCCCAAGCCCCTAGAGGCTCCAGGCCCCAGCAGTCT GGTTCCCACCCTTTCTATGATAGCACCACCTCCAGTCATGGCAAGTGCCCCCATCCCCAAGGCTCTGGGGACTCCTGTGCTCACACCCCC TACTGAAGCTGCAAGCCAAGACAGAATGCCTCAGGATCTAGATCTTGATATGTATATGGAGAACCTGGAGTGTGACATGGATAACATCAT CAGTGACCTCATGGATGAGGGCGAGGGACTGGACTTCAACTTTGAGCCAGATCCCTGAGTCATGCCTGGAAGCTTTGTCCCCTGCTTCAG ATGTGGAGCCAGGCGTGTTCATATCTACTCTTTACCCTTGAGCCCTCCCCAGGAATTTGGGACCCTGCTTTAGAGCTAGGGTGGGGTCTG GTCACACACAGGTGTTGAAGAAATTATAAAGATAAAGCTGCCCCATCTGGGGACGATATGGGGAGGGAGATGGGAGGGGAAAGGGGAGAG GGTTTTTCTCACTGTGCCAATTAGGGGGTAAGGCCCCCTCTCAGGAGCCATCATCGGCTTTCCCCATTCCTACCCACTTAGGCTTTGTAG CAAGATGAGCAATGCTGTTGGAAATGTGAAGTCACCAGTGGCCTTACCCCTGCCTTTGGGAGCAGGATTTTTTTGTAGAGAGTCTTATCT GAGCTGAGCCAGGCTAGCTGGAGCCTGGGATTTCTATGCAGTGGCCCCTTAGGCCAGTGATGTGCGGTGGGTGGGCTGTTTAGGGGATCT GGAAGGGCCAAGGTCTGAGCACTGGAGTGGCTCGCCAGGCCAAATCACCCTTAGAAGGCTGCAGATAACAGAAAGGCTTTTTATAAACTT TTAAAGAAATATAAACACAAATATAGAGATTTTTTAACCATGGCAGGGTGCTAGTGGTGGGCAGAATGCTTTTTTTTCTTTCTGAAGGCT TTGTGATAGTGACATGATACAAACACTACAGACAATAAATATTAGGAGACACAGGGAAGTGGGGAGAGGTGGGGAGTAATAGTAAACACA GGGAAGAGCTCCCCTACGGACCAGGTATAGAGAAAGGTCTATGCAGAAATAGGTTAGAGTTTCCCTAACAAAAAAGCTAACCCAGGTCCC CTCATTCCTTCAACTTGTGCCTGGGAGTGTGTGGTGTTAGGGTGCAGCCACACTCTTCTATGACCCAGCATGGGTTAGTGCTATGGTGGG AGAGTACATTGAAGGCCTGGAATTAGCTTGGGGCCAGGGAAGGGACTGGGAGGGGAGAGAAGAGAAGGAGGGAAGGATTTAGGATGGTAA AGTTAGGTACAGAGACCTCCCTGTTCAAGGCCCCTGACAGCTGTCCCTGCCCTTCTTCCCCTTCCCTGACTGCAGGGGTTATGTGGAAGT GTGTGTGGCAGCAGGCAGCGGGGAGGGGAGGAACAGGGAAGGGGGAGCTGGGGAGCTTGGCTGAGGGTCTGGGAAATGAGCAGGGATGGG GGGGGATGTGGATCAGGTTTACTAGCACCTGCCAGGGAGGCCATCTGGGGCTCCTTCTCCACCCCAGCCCCCAAAGCAGCCCTTCCCCCA GTGCCCTTTGCATCGTCCCCTCCCCCACCCCTGCTGTGGGTTCCCATCATTTCCTGTGTCAGCGCCTGGCCTACCCAGATTGTATCATGT >16795_16795_1_CIC-FOXO4_CIC_chr19_42799949_ENST00000575354_FOXO4_chrX_70320533_ENST00000374259_length(amino acids)=1612AA_BP= MRRTMYSAHRPLMPASSAASRGLGMFVWTNVEPRSVAVFPWHSLVPFLAPSQPDPSVQPSEAQQPASHPVASNQSKEPAESAAVAHERPP GGTGSADPERPPGATCPESPGPGPPHPLGVVESGKGPPPTTEEEASGPPGEPRLDSETESDHDDAFLSIMSPEIQLPLPPGKRRTQSLSA LPKERDSSSEKDGRSPNKREKDHIRRPMNAFMIFSKRHRALVHQRHPNQDNRTVSKILGEWWYALGPKEKQKYHDLAFQVKEAHFKAHPD WKWCNKDRKKSSSEAKPTSLGLAGGHKETRERSMSETGTAAAPGVSSELLSVAAQTLLSSDTKAPGSSSCGAERLHTVGGPGSARPRAFS HSGVHSLDGGEVDSQALQELTQMVSGPASYSGPKPSTQYGAPGPFAAPGEGGALAATGRPPLLPTRASRSQRAASEDMTSDEERMVICEE EGDDDVIADDGFGTTDIDLKCKERVTDSESGDSSGEDPEGNKGFGRKVFSPVIRSSFTHCRPPLDPEPPGPPDPPVAFGKGYGSAPSSSA SSPASSSASAATSFSLGSGTFKAQESGQGSTAGPLRPPPPGAGGPATPSKATRFLPMDPATFRRKRPESVGGLEPPGPSVIAAPPSGGGN ILQTLVLPPNKEEQEGGGARVPSAPAPSLAYGAPAAPLSRPAATMVTNVVRPVSSTPVPIASKPFPTSGRAEASPNDTAGARTEMGTGSR VPGGSPLGVSLVYSDKKSAAATSPAPHLVAGPLLGTVGKAPATVTNLLVGTPGYGAPAPPAVQFIAQGAPGGGTTAGSGAGAGSGPNGPV PLGILQPGALGKAGGITQVQYILPTLPQQLQVAPAPAPAPGTKAAAPSGPAPTTSIRFTLPPGTSTNGKVLAATAPTPGIPILQSVPSAP PPKAQSVSPVQAPPPGGSAQLLPGKVLVPLAAPSMSVRGGGAGQPLPLVSPPFSVPVQNGAQPPSKIIQLTPVPVSTPSGLVPPLSPATL PGPTSQPQKVLLPSSTRITYVQSAGGHALPLGTSPASSQAGTVTSYGPTSSVALGFTSLGPSGPAFVQPLLSAGQAPLLAPGQVGVSPVP SPQLPPACAAPGGPVITAFYSGSPAPTSSAPLAQPSQAPPSLVYTVATSTTPPAATILPKGPPAPATATPAPTSPFPSATAGSMTYSLVA PKAQRPSPKAPQKVKAAIASIPVGSFEAGASGRPGPAPRQPLEPGPVREPTAPESELEGQPTPPAPPPLPETWTPTARSSPPLPPPAEER TSAKGPETMASKFPSSSSDWRVPGQGLENRGEPPTPPSPAPAPAVAPGGSSESSSGRAAGDTPERKEAAGTGKKVKVRPPPLKKTFDSVD NRVLSEVDFEERFAELPEFRPEEVLPSPTLQSLATSPRAILGSYRKKRKNSTDLDSAPEDPTSPKRKMRRRSSCSSEPNTPKSAKCEGDI FTFDRTGTEAEDVLGELEYDKVPYSSLRRTLDQRRALVMQLFQDHGFFPSAQATAAFQARYADIFPSKVCLQLKIREVRQKIMQAATPTE -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for CIC-FOXO4 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for CIC-FOXO4 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for CIC-FOXO4 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | CIC | C4539848 | MENTAL RETARDATION, AUTOSOMAL DOMINANT 45 | 3 | GENOMICS_ENGLAND;UNIPROT |
| Hgene | CIC | C0020796 | Profound Mental Retardation | 2 | CTD_human |
| Hgene | CIC | C0025363 | Mental Retardation, Psychosocial | 2 | CTD_human |
| Hgene | CIC | C0917816 | Mental deficiency | 2 | CTD_human |
| Hgene | CIC | C3714756 | Intellectual Disability | 2 | CTD_human |
| Hgene | CIC | C0027627 | Neoplasm Metastasis | 1 | CTD_human |
| Hgene | CIC | C0041671 | Attention Deficit Disorder | 1 | CTD_human |
| Hgene | CIC | C0087012 | Ataxia, Spinocerebellar | 1 | CTD_human |
| Hgene | CIC | C0752120 | Spinocerebellar Ataxia Type 1 | 1 | CTD_human |
| Hgene | CIC | C0752121 | Spinocerebellar Ataxia Type 2 | 1 | CTD_human |
| Hgene | CIC | C0752122 | Spinocerebellar Ataxia Type 4 | 1 | CTD_human |
| Hgene | CIC | C0752123 | Spinocerebellar Ataxia Type 5 | 1 | CTD_human |
| Hgene | CIC | C0752124 | Spinocerebellar Ataxia Type 6 (disorder) | 1 | CTD_human |
| Hgene | CIC | C0752125 | Spinocerebellar Ataxia Type 7 | 1 | CTD_human |
| Hgene | CIC | C1263846 | Attention deficit hyperactivity disorder | 1 | CTD_human |
| Hgene | CIC | C1321905 | Minimal Brain Dysfunction | 1 | CTD_human |
| Hgene | CIC | C1510586 | Autism Spectrum Disorders | 1 | CTD_human |
| Tgene | C0025322 | Premature Menopause | 1 | GENOMICS_ENGLAND |
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