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 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:ATG4B-SEC23IP (FusionGDB2 ID:HG23192TG11196) |
Fusion Gene Summary for ATG4B-SEC23IP |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: ATG4B-SEC23IP | Fusion gene ID: hg23192tg11196 | Hgene | Tgene | Gene symbol | ATG4B | SEC23IP | Gene ID | 23192 | 11196 |
| Gene name | autophagy related 4B cysteine peptidase | SEC23 interacting protein | |
| Synonyms | APG4B|AUTL1 | MSTP053|P125|P125A | |
| Cytomap | ('ATG4B')('SEC23IP') 2q37.3 | 10q26.11-q26.12 | |
| Type of gene | protein-coding | protein-coding | |
| Description | cysteine protease ATG4BAPG4 autophagy 4 homolog BATG4 autophagy related 4 homolog BAUT-like 1 cysteine endopeptidaseautophagin-1autophagy-related cysteine endopeptidase 1autophagy-related protein 4 homolog BhAPG4B | SEC23-interacting protein | |
| Modification date | 20200329 | 20200313 | |
| UniProtAcc | . | . | |
| Ensembl transtripts involved in fusion gene | ENST00000396411, ENST00000402096, ENST00000404914, ENST00000405546, ENST00000474739, ENST00000491867, | ||
| Fusion gene scores | * DoF score | 5 X 4 X 4=80 | 7 X 9 X 4=252 |
| # samples | 4 | 7 | |
| ** MAII score | log2(4/80*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(7/252*10)=-1.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: ATG4B [Title/Abstract] AND SEC23IP [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | ATG4B(242606253)-SEC23IP(121678956), # samples:1 | ||
| Anticipated loss of major functional domain due to fusion event. | ATG4B-SEC23IP seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. ATG4B-SEC23IP seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. ATG4B-SEC23IP seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. ATG4B-SEC23IP seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | ATG4B | GO:0006508 | proteolysis | 15169837|18387192 |
| Hgene | ATG4B | GO:0006914 | autophagy | 18387192 |
| Hgene | ATG4B | GO:0051697 | protein delipidation | 25327288 |
| Fusion gene breakpoints across ATG4B (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene breakpoints across SEC23IP (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene information * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | STAD | TCGA-BR-8058-01A | ATG4B | chr2 | 242606253 | + | SEC23IP | chr10 | 121678956 | + |
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Fusion Gene ORF analysis for ATG4B-SEC23IP |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-intron | ENST00000396411 | ENST00000475542 | ATG4B | chr2 | 242606253 | + | SEC23IP | chr10 | 121678956 | + |
| 5CDS-intron | ENST00000402096 | ENST00000475542 | ATG4B | chr2 | 242606253 | + | SEC23IP | chr10 | 121678956 | + |
| 5CDS-intron | ENST00000404914 | ENST00000475542 | ATG4B | chr2 | 242606253 | + | SEC23IP | chr10 | 121678956 | + |
| 5CDS-intron | ENST00000405546 | ENST00000475542 | ATG4B | chr2 | 242606253 | + | SEC23IP | chr10 | 121678956 | + |
| 5CDS-intron | ENST00000474739 | ENST00000475542 | ATG4B | chr2 | 242606253 | + | SEC23IP | chr10 | 121678956 | + |
| In-frame | ENST00000396411 | ENST00000369075 | ATG4B | chr2 | 242606253 | + | SEC23IP | chr10 | 121678956 | + |
| In-frame | ENST00000396411 | ENST00000543134 | ATG4B | chr2 | 242606253 | + | SEC23IP | chr10 | 121678956 | + |
| In-frame | ENST00000402096 | ENST00000369075 | ATG4B | chr2 | 242606253 | + | SEC23IP | chr10 | 121678956 | + |
| In-frame | ENST00000402096 | ENST00000543134 | ATG4B | chr2 | 242606253 | + | SEC23IP | chr10 | 121678956 | + |
| In-frame | ENST00000404914 | ENST00000369075 | ATG4B | chr2 | 242606253 | + | SEC23IP | chr10 | 121678956 | + |
| In-frame | ENST00000404914 | ENST00000543134 | ATG4B | chr2 | 242606253 | + | SEC23IP | chr10 | 121678956 | + |
| In-frame | ENST00000405546 | ENST00000369075 | ATG4B | chr2 | 242606253 | + | SEC23IP | chr10 | 121678956 | + |
| In-frame | ENST00000405546 | ENST00000543134 | ATG4B | chr2 | 242606253 | + | SEC23IP | chr10 | 121678956 | + |
| In-frame | ENST00000474739 | ENST00000369075 | ATG4B | chr2 | 242606253 | + | SEC23IP | chr10 | 121678956 | + |
| In-frame | ENST00000474739 | ENST00000543134 | ATG4B | chr2 | 242606253 | + | SEC23IP | chr10 | 121678956 | + |
| intron-3CDS | ENST00000491867 | ENST00000369075 | ATG4B | chr2 | 242606253 | + | SEC23IP | chr10 | 121678956 | + |
| intron-3CDS | ENST00000491867 | ENST00000543134 | ATG4B | chr2 | 242606253 | + | SEC23IP | chr10 | 121678956 | + |
| intron-intron | ENST00000491867 | ENST00000475542 | ATG4B | chr2 | 242606253 | + | SEC23IP | chr10 | 121678956 | + |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000405546 | ATG4B | chr2 | 242606253 | + | ENST00000369075 | SEC23IP | chr10 | 121678956 | + | 3946 | 1234 | 238 | 2364 | 708 |
| ENST00000405546 | ATG4B | chr2 | 242606253 | + | ENST00000543134 | SEC23IP | chr10 | 121678956 | + | 2534 | 1234 | 238 | 2364 | 708 |
| ENST00000402096 | ATG4B | chr2 | 242606253 | + | ENST00000369075 | SEC23IP | chr10 | 121678956 | + | 3547 | 835 | 103 | 1965 | 620 |
| ENST00000402096 | ATG4B | chr2 | 242606253 | + | ENST00000543134 | SEC23IP | chr10 | 121678956 | + | 2135 | 835 | 103 | 1965 | 620 |
| ENST00000404914 | ATG4B | chr2 | 242606253 | + | ENST00000369075 | SEC23IP | chr10 | 121678956 | + | 3547 | 835 | 103 | 1965 | 620 |
| ENST00000404914 | ATG4B | chr2 | 242606253 | + | ENST00000543134 | SEC23IP | chr10 | 121678956 | + | 2135 | 835 | 103 | 1965 | 620 |
| ENST00000396411 | ATG4B | chr2 | 242606253 | + | ENST00000369075 | SEC23IP | chr10 | 121678956 | + | 3529 | 817 | 307 | 1947 | 546 |
| ENST00000396411 | ATG4B | chr2 | 242606253 | + | ENST00000543134 | SEC23IP | chr10 | 121678956 | + | 2117 | 817 | 307 | 1947 | 546 |
| ENST00000474739 | ATG4B | chr2 | 242606253 | + | ENST00000369075 | SEC23IP | chr10 | 121678956 | + | 3557 | 845 | 59 | 1975 | 638 |
| ENST00000474739 | ATG4B | chr2 | 242606253 | + | ENST00000543134 | SEC23IP | chr10 | 121678956 | + | 2145 | 845 | 59 | 1975 | 638 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000405546 | ENST00000369075 | ATG4B | chr2 | 242606253 | + | SEC23IP | chr10 | 121678956 | + | 0.000955339 | 0.9990446 |
| ENST00000405546 | ENST00000543134 | ATG4B | chr2 | 242606253 | + | SEC23IP | chr10 | 121678956 | + | 0.004703462 | 0.99529654 |
| ENST00000402096 | ENST00000369075 | ATG4B | chr2 | 242606253 | + | SEC23IP | chr10 | 121678956 | + | 0.00026999 | 0.99973005 |
| ENST00000402096 | ENST00000543134 | ATG4B | chr2 | 242606253 | + | SEC23IP | chr10 | 121678956 | + | 0.001046493 | 0.99895346 |
| ENST00000404914 | ENST00000369075 | ATG4B | chr2 | 242606253 | + | SEC23IP | chr10 | 121678956 | + | 0.00026999 | 0.99973005 |
| ENST00000404914 | ENST00000543134 | ATG4B | chr2 | 242606253 | + | SEC23IP | chr10 | 121678956 | + | 0.001046493 | 0.99895346 |
| ENST00000396411 | ENST00000369075 | ATG4B | chr2 | 242606253 | + | SEC23IP | chr10 | 121678956 | + | 0.001102364 | 0.99889755 |
| ENST00000396411 | ENST00000543134 | ATG4B | chr2 | 242606253 | + | SEC23IP | chr10 | 121678956 | + | 0.003071028 | 0.996929 |
| ENST00000474739 | ENST00000369075 | ATG4B | chr2 | 242606253 | + | SEC23IP | chr10 | 121678956 | + | 0.000599043 | 0.999401 |
| ENST00000474739 | ENST00000543134 | ATG4B | chr2 | 242606253 | + | SEC23IP | chr10 | 121678956 | + | 0.002178749 | 0.9978212 |
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Fusion Genomic Features for ATG4B-SEC23IP |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| ATG4B | chr2 | 242606253 | + | SEC23IP | chr10 | 121678955 | + | 4.19E-08 | 1 |
| ATG4B | chr2 | 242606253 | + | SEC23IP | chr10 | 121678955 | + | 4.19E-08 | 1 |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
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| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for ATG4B-SEC23IP |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:242606253/chr10:121678956) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| . | . |
| FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. | FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | SEC23IP | chr2:242606253 | chr10:121678956 | ENST00000369075 | 9 | 19 | 644_707 | 624 | 1443.0 | Domain | Note=SAM | |
| Tgene | SEC23IP | chr2:242606253 | chr10:121678956 | ENST00000369075 | 9 | 19 | 779_989 | 624 | 1443.0 | Domain | DDHD |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | SEC23IP | chr2:242606253 | chr10:121678956 | ENST00000369075 | 9 | 19 | 142_259 | 624 | 1443.0 | Compositional bias | Note=Pro-rich |
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Fusion Gene Sequence for ATG4B-SEC23IP |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >7568_7568_1_ATG4B-SEC23IP_ATG4B_chr2_242606253_ENST00000396411_SEC23IP_chr10_121678956_ENST00000369075_length(transcript)=3529nt_BP=817nt AGTCGGCGGCCGGACTGGGAAGATGGACGCAGCTACTCTGACCTACGACACTCTCCGGTTTGCTGAGTTTGAAGATTTTCCTGAGACCTC AGAGCCCGTTTGGATACTGGGTAGAAAATACAGCATTTTCACAGAAAAGGACGAGATCTTGTCTGATGTGGCATCTAGACTTTGGTTTAC ATACAGGAAAAACTTTCCAGCCATTGGAGGTTGTCGGGACATTTCACTCTCCAGTAAATGTGGCCCTTGGCGTTACTGAGTCCTAAGAGG GGGGACAGGCCCCACCTCGGACACAGGCTGGGGCTGCATGCTGCGGTGTGGACAGATGATCTTTGCCCAAGCCCTGGTGTGCCGGCACCT AGGCCGAGATTGGAGGTGGACACAAAGGAAGAGGCAGCCAGACAGCTACTTCAGCGTCCTCAACGCATTCATCGACAGGAAGGACAGTTA CTACTCCATTCACCAGATAGCGCAAATGGGAGTTGGCGAAGGCAAGTCCATAGGCCAGTGGTACGGGCCCAACACTGTCGCCCAGGTCCT GAAGAAGCTTGCTGTCTTCGATACGTGGAGCTCCTTGGCGGTCCACATTGCAATGGACAACACTGTTGTGATGGAGGAAATCAGAAGGTT GTGCAGGACCAGCGTTCCCTGTGCAGGCGCCACTGCGTTTCCTGCAGATTCCGACCGGCACTGCAACGGATTCCCTGCCGGAGCTGAGGT CACCAACAGGCCGTCGCCATGGAGACCCCTGGTACTTCTCATTCCCCTGCGCCTGGGGCTCACGGACATCAACGAGGCCTACGTGGAGAC GCTGAAGATGCCTGAAGAGCCAAAGCTGACTTTGGATGAGTCGTATGACCTTGTTGTTGAAAATAAAGAAGTCCTAACTTTGCAAGAAAC TCTGGAAGCACTTAGCCTCTCTGAATATTTTAGCACTTTTGAAAAGGAAAAGATTGATATGGAGTCCCTGCTTATGTGTACAGTTGATGA CCTGAAGGAAATGGGGATACCCCTTGGACCCAGAAAGAAGATAGCTAACTTTGTAGAACATAAAGCAGCCAAACTGAAAAAAGCAGCGTC AGAAAAGAAGGCAGTGGCGGCCACTTCTACAAAAGGACAAGAGCAAAGTGCCCAGAAGACTAAAGACATGGCTTCCCTCCCCTCAGAATC CAATGAGCCAAAGAGGAAACTTCCAGTTGGTGCTTGCGTGTCTTCTGTGTGTGTGAATTATGAATCTTTTGAAGTTGGCGCCGGACAGGT TTCTGTTGCTTACAACTCATTAGATTTTGAACCAGAGATATTCTTTGCCTTGGGGTCTCCAATTGCTATGTTTCTCACTATTCGAGGAGT TGATAGGATAGATGAGAATTACAGCCTTCCTACCTGTAAAGGGTTCTTCAATATTTATCATCCGCTTGATCCAGTGGCATATAGATTAGA ACCTATGATTGTTCCAGATTTGGACCTAAAAGCTGTTCTCATTCCACATCACAAAGGCAGAAAAAGACTTCATTTAGAATTGAAAGAGAG TCTCTCTCGTATGGGATCTGATTTGAAGCAGGGTTTTATTAGCTCTCTCAAAAGTGCTTGGCAGACATTAAATGAGTTTGCCCGTGCTCA TACGTCTTCAACCCAGTTGCAAGAAGAATTGGAGAAGGTGGCCAATCAGATCAAAGAAGAAGAAGAAAAGCAAGTAGTTGAAGCAGAAAA GGTTGTTGAAAGTCCAGATTTTTCCAAGGATGAGGACTACTTAGGAAAGGTTGGAATGTTAAATGGAGGCCGCCGAATTGACTACGTTCT CCAAGAAAAACCAATAGAGAGTTTTAATGAATACCTTTTCGCTCTTCAGAGTCACTTATGCTATTGGGAATCTGAAGATACTGCTCTGTT ACTACTTAAAGAAATTTATCGAACAATGAACATTAGTCCAGAACAGCCCCAGCATTGATCAAACTTCAGTTTTACTGTACTTTCTTGTCT GCACAGAAAGTCCCAGTACAACTTCCATTGCTGAGAAAATCCTCAGAGGACTTTCCCACTTCGCTCCTGTGATGGATGACAGAAGAGTGA TTCATTAACAATTGCTCAGCCACAATTCTCGGATATAGGGATTCAAAAGACAGGACACAGAACTAACACAGTGAAAAAAATCAGTACCAC ATTTGGACAGTATAGGTGAGAAAACATAATTATAAAAATGATGCCATGAAAAATTCCACAGATCAGTTTAGTTGTATAGTTGTCAAAGTT ATATGTGATATCAATGAAGAAATATTTGTAGCATGTAAACGGTTATTTCTGTTTCTTAAAAAGTATTGTTAGTGGGCTATTAAACTTGGA TTTTTCTTTTTATTAATGCAGTATGTTCTTTTTATTCAAGTATGAACTTGTTGAGAAACTATAGTAATATGATTTTTAAGAGATTTATGT TCTACTTAAAATGTGAATTGTACTTCTGAGCTGCCTTAATGCAAGGTCATTTATATTTGTTAAGAGGAAATAATCAAGATCACTCATATC CCAACTGAATCTGAGGTTTTATAAATCCCTCAAACGATTGCTGAGAGCCTGATTGTGGAAAGAAGTGAGATGCACCTTATTTTCAAGAAG TCCTGGGAAGCGCTCTCCTAGCACGTCCATTTCCAGGAGGAGAAGCAAGCAGATGAGAGGTTTTCCATTTTGTCATCCAAGGTAGCTGTG CACTTGCCTTGTTGCTGAAGTTCCAATAATGTGAAAACCAAAGTAGAGGTTTTTTTCTTCTTCTTTTTGTTTTCTATTAATTTCACTTAT ACCAAAGTGTTTGAAAGTATGAAATGTGTTGCTTCTGAGTTATATAAGGCTACTTCATGACAAGACTGCTTTGTAATATTTCACTTTGTT TTACTACAAATTCAGATCACTTTGTTTTACTATAAATTCAGATTATCCAAATATTTTCCTAATACTATGTGGGAATGCTGATTTTCTTTT GTTACGTAGTGGAAACATTTTGCATTGTTTACATAGTTCTCATGGAACATGGAAATTTTTGAAAGTGATATATGATACACATTTTTTGTG TATGTATTCTAATTAGTGTGAATAAAGCAGTAACATTAATGCATTTTTTAAGCAGCAAACTTATGTATTTCTCTTGTCTTCCTTAAAAGT GTCCCCATGAACTCAGTGTTTATTCCCTTTTCATTTTGAGTACCTGCTTATATGGTCAGTATGTAACGTTAGCATTGGCTCCTAATGGTA GAATTAGAACAGCAAGATTGTAGAGCTGTAATTGACTCCAGACAACATAGATTTCAGCCACCTCATTCTACAGCTGAGGCCAGGACAATA AATGCCTTTCCCAGACTGGGTAGTGGCAGATCTGGGATGGAATATGGTTTTCTTGATTCCCTTTCAGCCTTCATTTCTCTCTCTCAGGAC TACTACTTTTTAATTACTTTTCACTTAATTTCCCAATACTGATGAAATAAAGAAAAATGAGGGTTATTTATATACATTTCAATAAAATCC >7568_7568_1_ATG4B-SEC23IP_ATG4B_chr2_242606253_ENST00000396411_SEC23IP_chr10_121678956_ENST00000369075_length(amino acids)=546AA_BP=168 MLRCGQMIFAQALVCRHLGRDWRWTQRKRQPDSYFSVLNAFIDRKDSYYSIHQIAQMGVGEGKSIGQWYGPNTVAQVLKKLAVFDTWSSL AVHIAMDNTVVMEEIRRLCRTSVPCAGATAFPADSDRHCNGFPAGAEVTNRPSPWRPLVLLIPLRLGLTDINEAYVETLKMPEEPKLTLD ESYDLVVENKEVLTLQETLEALSLSEYFSTFEKEKIDMESLLMCTVDDLKEMGIPLGPRKKIANFVEHKAAKLKKAASEKKAVAATSTKG QEQSAQKTKDMASLPSESNEPKRKLPVGACVSSVCVNYESFEVGAGQVSVAYNSLDFEPEIFFALGSPIAMFLTIRGVDRIDENYSLPTC KGFFNIYHPLDPVAYRLEPMIVPDLDLKAVLIPHHKGRKRLHLELKESLSRMGSDLKQGFISSLKSAWQTLNEFARAHTSSTQLQEELEK VANQIKEEEEKQVVEAEKVVESPDFSKDEDYLGKVGMLNGGRRIDYVLQEKPIESFNEYLFALQSHLCYWESEDTALLLLKEIYRTMNIS -------------------------------------------------------------- >7568_7568_2_ATG4B-SEC23IP_ATG4B_chr2_242606253_ENST00000396411_SEC23IP_chr10_121678956_ENST00000543134_length(transcript)=2117nt_BP=817nt AGTCGGCGGCCGGACTGGGAAGATGGACGCAGCTACTCTGACCTACGACACTCTCCGGTTTGCTGAGTTTGAAGATTTTCCTGAGACCTC AGAGCCCGTTTGGATACTGGGTAGAAAATACAGCATTTTCACAGAAAAGGACGAGATCTTGTCTGATGTGGCATCTAGACTTTGGTTTAC ATACAGGAAAAACTTTCCAGCCATTGGAGGTTGTCGGGACATTTCACTCTCCAGTAAATGTGGCCCTTGGCGTTACTGAGTCCTAAGAGG GGGGACAGGCCCCACCTCGGACACAGGCTGGGGCTGCATGCTGCGGTGTGGACAGATGATCTTTGCCCAAGCCCTGGTGTGCCGGCACCT AGGCCGAGATTGGAGGTGGACACAAAGGAAGAGGCAGCCAGACAGCTACTTCAGCGTCCTCAACGCATTCATCGACAGGAAGGACAGTTA CTACTCCATTCACCAGATAGCGCAAATGGGAGTTGGCGAAGGCAAGTCCATAGGCCAGTGGTACGGGCCCAACACTGTCGCCCAGGTCCT GAAGAAGCTTGCTGTCTTCGATACGTGGAGCTCCTTGGCGGTCCACATTGCAATGGACAACACTGTTGTGATGGAGGAAATCAGAAGGTT GTGCAGGACCAGCGTTCCCTGTGCAGGCGCCACTGCGTTTCCTGCAGATTCCGACCGGCACTGCAACGGATTCCCTGCCGGAGCTGAGGT CACCAACAGGCCGTCGCCATGGAGACCCCTGGTACTTCTCATTCCCCTGCGCCTGGGGCTCACGGACATCAACGAGGCCTACGTGGAGAC GCTGAAGATGCCTGAAGAGCCAAAGCTGACTTTGGATGAGTCGTATGACCTTGTTGTTGAAAATAAAGAAGTCCTAACTTTGCAAGAAAC TCTGGAAGCACTTAGCCTCTCTGAATATTTTAGCACTTTTGAAAAGGAAAAGATTGATATGGAGTCCCTGCTTATGTGTACAGTTGATGA CCTGAAGGAAATGGGGATACCCCTTGGACCCAGAAAGAAGATAGCTAACTTTGTAGAACATAAAGCAGCCAAACTGAAAAAAGCAGCGTC AGAAAAGAAGGCAGTGGCGGCCACTTCTACAAAAGGACAAGAGCAAAGTGCCCAGAAGACTAAAGACATGGCTTCCCTCCCCTCAGAATC CAATGAGCCAAAGAGGAAACTTCCAGTTGGTGCTTGCGTGTCTTCTGTGTGTGTGAATTATGAATCTTTTGAAGTTGGCGCCGGACAGGT TTCTGTTGCTTACAACTCATTAGATTTTGAACCAGAGATATTCTTTGCCTTGGGGTCTCCAATTGCTATGTTTCTCACTATTCGAGGAGT TGATAGGATAGATGAGAATTACAGCCTTCCTACCTGTAAAGGGTTCTTCAATATTTATCATCCGCTTGATCCAGTGGCATATAGATTAGA ACCTATGATTGTTCCAGATTTGGACCTAAAAGCTGTTCTCATTCCACATCACAAAGGCAGAAAAAGACTTCATTTAGAATTGAAAGAGAG TCTCTCTCGTATGGGATCTGATTTGAAGCAGGGTTTTATTAGCTCTCTCAAAAGTGCTTGGCAGACATTAAATGAGTTTGCCCGTGCTCA TACGTCTTCAACCCAGTTGCAAGAAGAATTGGAGAAGGTGGCCAATCAGATCAAAGAAGAAGAAGAAAAGCAAGTAGTTGAAGCAGAAAA GGTTGTTGAAAGTCCAGATTTTTCCAAGGATGAGGACTACTTAGGAAAGGTTGGAATGTTAAATGGAGGCCGCCGAATTGACTACGTTCT CCAAGAAAAACCAATAGAGAGTTTTAATGAATACCTTTTCGCTCTTCAGAGTCACTTATGCTATTGGGAATCTGAAGATACTGCTCTGTT ACTACTTAAAGAAATTTATCGAACAATGAACATTAGTCCAGAACAGCCCCAGCATTGATCAAACTTCAGTTTTACTGTACTTTCTTGTCT GCACAGAAAGTCCCAGTACAACTTCCATTGCTGAGAAAATCCTCAGAGGACTTTCCCACTTCGCTCCTGTGATGGATGACAGAAGAGTGA >7568_7568_2_ATG4B-SEC23IP_ATG4B_chr2_242606253_ENST00000396411_SEC23IP_chr10_121678956_ENST00000543134_length(amino acids)=546AA_BP=168 MLRCGQMIFAQALVCRHLGRDWRWTQRKRQPDSYFSVLNAFIDRKDSYYSIHQIAQMGVGEGKSIGQWYGPNTVAQVLKKLAVFDTWSSL AVHIAMDNTVVMEEIRRLCRTSVPCAGATAFPADSDRHCNGFPAGAEVTNRPSPWRPLVLLIPLRLGLTDINEAYVETLKMPEEPKLTLD ESYDLVVENKEVLTLQETLEALSLSEYFSTFEKEKIDMESLLMCTVDDLKEMGIPLGPRKKIANFVEHKAAKLKKAASEKKAVAATSTKG QEQSAQKTKDMASLPSESNEPKRKLPVGACVSSVCVNYESFEVGAGQVSVAYNSLDFEPEIFFALGSPIAMFLTIRGVDRIDENYSLPTC KGFFNIYHPLDPVAYRLEPMIVPDLDLKAVLIPHHKGRKRLHLELKESLSRMGSDLKQGFISSLKSAWQTLNEFARAHTSSTQLQEELEK VANQIKEEEEKQVVEAEKVVESPDFSKDEDYLGKVGMLNGGRRIDYVLQEKPIESFNEYLFALQSHLCYWESEDTALLLLKEIYRTMNIS -------------------------------------------------------------- >7568_7568_3_ATG4B-SEC23IP_ATG4B_chr2_242606253_ENST00000402096_SEC23IP_chr10_121678956_ENST00000369075_length(transcript)=3547nt_BP=835nt GCGCCGGCACACCTATTGGCCCCCGCGGCGTCCCGTCGCCGCGTCGCGTTGCTGGCCCGTCGGAGCGACGCCGCTCGGGTCAGTCGGCGG CCGGACTGGGAAGATGGACGCAGCTACTCTGACCTACGACACTCTCCGGTTTGCTGAGTTTGAAGATTTTCCTGAGACCTCAGAGCCCGT TTGGATACTGGGTAGAAAATACAGCATTTTCACAGAAAAGGACGAGATCTTGTCTGATGTGGCATCTAGACTTTGGTTTACATACAGGAA AAACTTTCCAGCCATTGGGGGGACAGGCCCCACCTCGGACACAGGCTGGGGCTGCATGCTGCGGTGTGGACAGATGATCTTTGCCCAAGC CCTGGTGTGCCGGCACCTAGGCCGAGATTGGAGGTGGACACAAAGGAAGAGGCAGCCAGACAGCTACTTCAGCGTCCTCAACGCATTCAT CGACAGGAAGGACAGTTACTACTCCATTCACCAGATAGCGCAAATGGGAGTTGGCGAAGGCAAGTCCATAGGCCAGTGGTACGGGCCCAA CACTGTCGCCCAGGTCCTGAAGAAGCTTGCTGTCTTCGATACGTGGAGCTCCTTGGCGGTCCACATTGCAATGGACAACACTGTTGTGAT GGAGGAAATCAGAAGGTTGTGCAGGACCAGCGTTCCCTGTGCAGGCGCCACTGCGTTTCCTGCAGATTCCGACCGGCACTGCAACGGATT CCCTGCCGGAGCTGAGGTCACCAACAGGCCGTCGCCATGGAGACCCCTGGTACTTCTCATTCCCCTGCGCCTGGGGCTCACGGACATCAA CGAGGCCTACGTGGAGACGCTGAAGATGCCTGAAGAGCCAAAGCTGACTTTGGATGAGTCGTATGACCTTGTTGTTGAAAATAAAGAAGT CCTAACTTTGCAAGAAACTCTGGAAGCACTTAGCCTCTCTGAATATTTTAGCACTTTTGAAAAGGAAAAGATTGATATGGAGTCCCTGCT TATGTGTACAGTTGATGACCTGAAGGAAATGGGGATACCCCTTGGACCCAGAAAGAAGATAGCTAACTTTGTAGAACATAAAGCAGCCAA ACTGAAAAAAGCAGCGTCAGAAAAGAAGGCAGTGGCGGCCACTTCTACAAAAGGACAAGAGCAAAGTGCCCAGAAGACTAAAGACATGGC TTCCCTCCCCTCAGAATCCAATGAGCCAAAGAGGAAACTTCCAGTTGGTGCTTGCGTGTCTTCTGTGTGTGTGAATTATGAATCTTTTGA AGTTGGCGCCGGACAGGTTTCTGTTGCTTACAACTCATTAGATTTTGAACCAGAGATATTCTTTGCCTTGGGGTCTCCAATTGCTATGTT TCTCACTATTCGAGGAGTTGATAGGATAGATGAGAATTACAGCCTTCCTACCTGTAAAGGGTTCTTCAATATTTATCATCCGCTTGATCC AGTGGCATATAGATTAGAACCTATGATTGTTCCAGATTTGGACCTAAAAGCTGTTCTCATTCCACATCACAAAGGCAGAAAAAGACTTCA TTTAGAATTGAAAGAGAGTCTCTCTCGTATGGGATCTGATTTGAAGCAGGGTTTTATTAGCTCTCTCAAAAGTGCTTGGCAGACATTAAA TGAGTTTGCCCGTGCTCATACGTCTTCAACCCAGTTGCAAGAAGAATTGGAGAAGGTGGCCAATCAGATCAAAGAAGAAGAAGAAAAGCA AGTAGTTGAAGCAGAAAAGGTTGTTGAAAGTCCAGATTTTTCCAAGGATGAGGACTACTTAGGAAAGGTTGGAATGTTAAATGGAGGCCG CCGAATTGACTACGTTCTCCAAGAAAAACCAATAGAGAGTTTTAATGAATACCTTTTCGCTCTTCAGAGTCACTTATGCTATTGGGAATC TGAAGATACTGCTCTGTTACTACTTAAAGAAATTTATCGAACAATGAACATTAGTCCAGAACAGCCCCAGCATTGATCAAACTTCAGTTT TACTGTACTTTCTTGTCTGCACAGAAAGTCCCAGTACAACTTCCATTGCTGAGAAAATCCTCAGAGGACTTTCCCACTTCGCTCCTGTGA TGGATGACAGAAGAGTGATTCATTAACAATTGCTCAGCCACAATTCTCGGATATAGGGATTCAAAAGACAGGACACAGAACTAACACAGT GAAAAAAATCAGTACCACATTTGGACAGTATAGGTGAGAAAACATAATTATAAAAATGATGCCATGAAAAATTCCACAGATCAGTTTAGT TGTATAGTTGTCAAAGTTATATGTGATATCAATGAAGAAATATTTGTAGCATGTAAACGGTTATTTCTGTTTCTTAAAAAGTATTGTTAG TGGGCTATTAAACTTGGATTTTTCTTTTTATTAATGCAGTATGTTCTTTTTATTCAAGTATGAACTTGTTGAGAAACTATAGTAATATGA TTTTTAAGAGATTTATGTTCTACTTAAAATGTGAATTGTACTTCTGAGCTGCCTTAATGCAAGGTCATTTATATTTGTTAAGAGGAAATA ATCAAGATCACTCATATCCCAACTGAATCTGAGGTTTTATAAATCCCTCAAACGATTGCTGAGAGCCTGATTGTGGAAAGAAGTGAGATG CACCTTATTTTCAAGAAGTCCTGGGAAGCGCTCTCCTAGCACGTCCATTTCCAGGAGGAGAAGCAAGCAGATGAGAGGTTTTCCATTTTG TCATCCAAGGTAGCTGTGCACTTGCCTTGTTGCTGAAGTTCCAATAATGTGAAAACCAAAGTAGAGGTTTTTTTCTTCTTCTTTTTGTTT TCTATTAATTTCACTTATACCAAAGTGTTTGAAAGTATGAAATGTGTTGCTTCTGAGTTATATAAGGCTACTTCATGACAAGACTGCTTT GTAATATTTCACTTTGTTTTACTACAAATTCAGATCACTTTGTTTTACTATAAATTCAGATTATCCAAATATTTTCCTAATACTATGTGG GAATGCTGATTTTCTTTTGTTACGTAGTGGAAACATTTTGCATTGTTTACATAGTTCTCATGGAACATGGAAATTTTTGAAAGTGATATA TGATACACATTTTTTGTGTATGTATTCTAATTAGTGTGAATAAAGCAGTAACATTAATGCATTTTTTAAGCAGCAAACTTATGTATTTCT CTTGTCTTCCTTAAAAGTGTCCCCATGAACTCAGTGTTTATTCCCTTTTCATTTTGAGTACCTGCTTATATGGTCAGTATGTAACGTTAG CATTGGCTCCTAATGGTAGAATTAGAACAGCAAGATTGTAGAGCTGTAATTGACTCCAGACAACATAGATTTCAGCCACCTCATTCTACA GCTGAGGCCAGGACAATAAATGCCTTTCCCAGACTGGGTAGTGGCAGATCTGGGATGGAATATGGTTTTCTTGATTCCCTTTCAGCCTTC ATTTCTCTCTCTCAGGACTACTACTTTTTAATTACTTTTCACTTAATTTCCCAATACTGATGAAATAAAGAAAAATGAGGGTTATTTATA >7568_7568_3_ATG4B-SEC23IP_ATG4B_chr2_242606253_ENST00000402096_SEC23IP_chr10_121678956_ENST00000369075_length(amino acids)=620AA_BP=242 MDAATLTYDTLRFAEFEDFPETSEPVWILGRKYSIFTEKDEILSDVASRLWFTYRKNFPAIGGTGPTSDTGWGCMLRCGQMIFAQALVCR HLGRDWRWTQRKRQPDSYFSVLNAFIDRKDSYYSIHQIAQMGVGEGKSIGQWYGPNTVAQVLKKLAVFDTWSSLAVHIAMDNTVVMEEIR RLCRTSVPCAGATAFPADSDRHCNGFPAGAEVTNRPSPWRPLVLLIPLRLGLTDINEAYVETLKMPEEPKLTLDESYDLVVENKEVLTLQ ETLEALSLSEYFSTFEKEKIDMESLLMCTVDDLKEMGIPLGPRKKIANFVEHKAAKLKKAASEKKAVAATSTKGQEQSAQKTKDMASLPS ESNEPKRKLPVGACVSSVCVNYESFEVGAGQVSVAYNSLDFEPEIFFALGSPIAMFLTIRGVDRIDENYSLPTCKGFFNIYHPLDPVAYR LEPMIVPDLDLKAVLIPHHKGRKRLHLELKESLSRMGSDLKQGFISSLKSAWQTLNEFARAHTSSTQLQEELEKVANQIKEEEEKQVVEA -------------------------------------------------------------- >7568_7568_4_ATG4B-SEC23IP_ATG4B_chr2_242606253_ENST00000402096_SEC23IP_chr10_121678956_ENST00000543134_length(transcript)=2135nt_BP=835nt GCGCCGGCACACCTATTGGCCCCCGCGGCGTCCCGTCGCCGCGTCGCGTTGCTGGCCCGTCGGAGCGACGCCGCTCGGGTCAGTCGGCGG CCGGACTGGGAAGATGGACGCAGCTACTCTGACCTACGACACTCTCCGGTTTGCTGAGTTTGAAGATTTTCCTGAGACCTCAGAGCCCGT TTGGATACTGGGTAGAAAATACAGCATTTTCACAGAAAAGGACGAGATCTTGTCTGATGTGGCATCTAGACTTTGGTTTACATACAGGAA AAACTTTCCAGCCATTGGGGGGACAGGCCCCACCTCGGACACAGGCTGGGGCTGCATGCTGCGGTGTGGACAGATGATCTTTGCCCAAGC CCTGGTGTGCCGGCACCTAGGCCGAGATTGGAGGTGGACACAAAGGAAGAGGCAGCCAGACAGCTACTTCAGCGTCCTCAACGCATTCAT CGACAGGAAGGACAGTTACTACTCCATTCACCAGATAGCGCAAATGGGAGTTGGCGAAGGCAAGTCCATAGGCCAGTGGTACGGGCCCAA CACTGTCGCCCAGGTCCTGAAGAAGCTTGCTGTCTTCGATACGTGGAGCTCCTTGGCGGTCCACATTGCAATGGACAACACTGTTGTGAT GGAGGAAATCAGAAGGTTGTGCAGGACCAGCGTTCCCTGTGCAGGCGCCACTGCGTTTCCTGCAGATTCCGACCGGCACTGCAACGGATT CCCTGCCGGAGCTGAGGTCACCAACAGGCCGTCGCCATGGAGACCCCTGGTACTTCTCATTCCCCTGCGCCTGGGGCTCACGGACATCAA CGAGGCCTACGTGGAGACGCTGAAGATGCCTGAAGAGCCAAAGCTGACTTTGGATGAGTCGTATGACCTTGTTGTTGAAAATAAAGAAGT CCTAACTTTGCAAGAAACTCTGGAAGCACTTAGCCTCTCTGAATATTTTAGCACTTTTGAAAAGGAAAAGATTGATATGGAGTCCCTGCT TATGTGTACAGTTGATGACCTGAAGGAAATGGGGATACCCCTTGGACCCAGAAAGAAGATAGCTAACTTTGTAGAACATAAAGCAGCCAA ACTGAAAAAAGCAGCGTCAGAAAAGAAGGCAGTGGCGGCCACTTCTACAAAAGGACAAGAGCAAAGTGCCCAGAAGACTAAAGACATGGC TTCCCTCCCCTCAGAATCCAATGAGCCAAAGAGGAAACTTCCAGTTGGTGCTTGCGTGTCTTCTGTGTGTGTGAATTATGAATCTTTTGA AGTTGGCGCCGGACAGGTTTCTGTTGCTTACAACTCATTAGATTTTGAACCAGAGATATTCTTTGCCTTGGGGTCTCCAATTGCTATGTT TCTCACTATTCGAGGAGTTGATAGGATAGATGAGAATTACAGCCTTCCTACCTGTAAAGGGTTCTTCAATATTTATCATCCGCTTGATCC AGTGGCATATAGATTAGAACCTATGATTGTTCCAGATTTGGACCTAAAAGCTGTTCTCATTCCACATCACAAAGGCAGAAAAAGACTTCA TTTAGAATTGAAAGAGAGTCTCTCTCGTATGGGATCTGATTTGAAGCAGGGTTTTATTAGCTCTCTCAAAAGTGCTTGGCAGACATTAAA TGAGTTTGCCCGTGCTCATACGTCTTCAACCCAGTTGCAAGAAGAATTGGAGAAGGTGGCCAATCAGATCAAAGAAGAAGAAGAAAAGCA AGTAGTTGAAGCAGAAAAGGTTGTTGAAAGTCCAGATTTTTCCAAGGATGAGGACTACTTAGGAAAGGTTGGAATGTTAAATGGAGGCCG CCGAATTGACTACGTTCTCCAAGAAAAACCAATAGAGAGTTTTAATGAATACCTTTTCGCTCTTCAGAGTCACTTATGCTATTGGGAATC TGAAGATACTGCTCTGTTACTACTTAAAGAAATTTATCGAACAATGAACATTAGTCCAGAACAGCCCCAGCATTGATCAAACTTCAGTTT TACTGTACTTTCTTGTCTGCACAGAAAGTCCCAGTACAACTTCCATTGCTGAGAAAATCCTCAGAGGACTTTCCCACTTCGCTCCTGTGA >7568_7568_4_ATG4B-SEC23IP_ATG4B_chr2_242606253_ENST00000402096_SEC23IP_chr10_121678956_ENST00000543134_length(amino acids)=620AA_BP=242 MDAATLTYDTLRFAEFEDFPETSEPVWILGRKYSIFTEKDEILSDVASRLWFTYRKNFPAIGGTGPTSDTGWGCMLRCGQMIFAQALVCR HLGRDWRWTQRKRQPDSYFSVLNAFIDRKDSYYSIHQIAQMGVGEGKSIGQWYGPNTVAQVLKKLAVFDTWSSLAVHIAMDNTVVMEEIR RLCRTSVPCAGATAFPADSDRHCNGFPAGAEVTNRPSPWRPLVLLIPLRLGLTDINEAYVETLKMPEEPKLTLDESYDLVVENKEVLTLQ ETLEALSLSEYFSTFEKEKIDMESLLMCTVDDLKEMGIPLGPRKKIANFVEHKAAKLKKAASEKKAVAATSTKGQEQSAQKTKDMASLPS ESNEPKRKLPVGACVSSVCVNYESFEVGAGQVSVAYNSLDFEPEIFFALGSPIAMFLTIRGVDRIDENYSLPTCKGFFNIYHPLDPVAYR LEPMIVPDLDLKAVLIPHHKGRKRLHLELKESLSRMGSDLKQGFISSLKSAWQTLNEFARAHTSSTQLQEELEKVANQIKEEEEKQVVEA -------------------------------------------------------------- >7568_7568_5_ATG4B-SEC23IP_ATG4B_chr2_242606253_ENST00000404914_SEC23IP_chr10_121678956_ENST00000369075_length(transcript)=3547nt_BP=835nt GCGCCGGCACACCTATTGGCCCCCGCGGCGTCCCGTCGCCGCGTCGCGTTGCTGGCCCGTCGGAGCGACGCCGCTCGGGTCAGTCGGCGG CCGGACTGGGAAGATGGACGCAGCTACTCTGACCTACGACACTCTCCGGTTTGCTGAGTTTGAAGATTTTCCTGAGACCTCAGAGCCCGT TTGGATACTGGGTAGAAAATACAGCATTTTCACAGAAAAGGACGAGATCTTGTCTGATGTGGCATCTAGACTTTGGTTTACATACAGGAA AAACTTTCCAGCCATTGGGGGGACAGGCCCCACCTCGGACACAGGCTGGGGCTGCATGCTGCGGTGTGGACAGATGATCTTTGCCCAAGC CCTGGTGTGCCGGCACCTAGGCCGAGATTGGAGGTGGACACAAAGGAAGAGGCAGCCAGACAGCTACTTCAGCGTCCTCAACGCATTCAT CGACAGGAAGGACAGTTACTACTCCATTCACCAGATAGCGCAAATGGGAGTTGGCGAAGGCAAGTCCATAGGCCAGTGGTACGGGCCCAA CACTGTCGCCCAGGTCCTGAAGAAGCTTGCTGTCTTCGATACGTGGAGCTCCTTGGCGGTCCACATTGCAATGGACAACACTGTTGTGAT GGAGGAAATCAGAAGGTTGTGCAGGACCAGCGTTCCCTGTGCAGGCGCCACTGCGTTTCCTGCAGATTCCGACCGGCACTGCAACGGATT CCCTGCCGGAGCTGAGGTCACCAACAGGCCGTCGCCATGGAGACCCCTGGTACTTCTCATTCCCCTGCGCCTGGGGCTCACGGACATCAA CGAGGCCTACGTGGAGACGCTGAAGATGCCTGAAGAGCCAAAGCTGACTTTGGATGAGTCGTATGACCTTGTTGTTGAAAATAAAGAAGT CCTAACTTTGCAAGAAACTCTGGAAGCACTTAGCCTCTCTGAATATTTTAGCACTTTTGAAAAGGAAAAGATTGATATGGAGTCCCTGCT TATGTGTACAGTTGATGACCTGAAGGAAATGGGGATACCCCTTGGACCCAGAAAGAAGATAGCTAACTTTGTAGAACATAAAGCAGCCAA ACTGAAAAAAGCAGCGTCAGAAAAGAAGGCAGTGGCGGCCACTTCTACAAAAGGACAAGAGCAAAGTGCCCAGAAGACTAAAGACATGGC TTCCCTCCCCTCAGAATCCAATGAGCCAAAGAGGAAACTTCCAGTTGGTGCTTGCGTGTCTTCTGTGTGTGTGAATTATGAATCTTTTGA AGTTGGCGCCGGACAGGTTTCTGTTGCTTACAACTCATTAGATTTTGAACCAGAGATATTCTTTGCCTTGGGGTCTCCAATTGCTATGTT TCTCACTATTCGAGGAGTTGATAGGATAGATGAGAATTACAGCCTTCCTACCTGTAAAGGGTTCTTCAATATTTATCATCCGCTTGATCC AGTGGCATATAGATTAGAACCTATGATTGTTCCAGATTTGGACCTAAAAGCTGTTCTCATTCCACATCACAAAGGCAGAAAAAGACTTCA TTTAGAATTGAAAGAGAGTCTCTCTCGTATGGGATCTGATTTGAAGCAGGGTTTTATTAGCTCTCTCAAAAGTGCTTGGCAGACATTAAA TGAGTTTGCCCGTGCTCATACGTCTTCAACCCAGTTGCAAGAAGAATTGGAGAAGGTGGCCAATCAGATCAAAGAAGAAGAAGAAAAGCA AGTAGTTGAAGCAGAAAAGGTTGTTGAAAGTCCAGATTTTTCCAAGGATGAGGACTACTTAGGAAAGGTTGGAATGTTAAATGGAGGCCG CCGAATTGACTACGTTCTCCAAGAAAAACCAATAGAGAGTTTTAATGAATACCTTTTCGCTCTTCAGAGTCACTTATGCTATTGGGAATC TGAAGATACTGCTCTGTTACTACTTAAAGAAATTTATCGAACAATGAACATTAGTCCAGAACAGCCCCAGCATTGATCAAACTTCAGTTT TACTGTACTTTCTTGTCTGCACAGAAAGTCCCAGTACAACTTCCATTGCTGAGAAAATCCTCAGAGGACTTTCCCACTTCGCTCCTGTGA TGGATGACAGAAGAGTGATTCATTAACAATTGCTCAGCCACAATTCTCGGATATAGGGATTCAAAAGACAGGACACAGAACTAACACAGT GAAAAAAATCAGTACCACATTTGGACAGTATAGGTGAGAAAACATAATTATAAAAATGATGCCATGAAAAATTCCACAGATCAGTTTAGT TGTATAGTTGTCAAAGTTATATGTGATATCAATGAAGAAATATTTGTAGCATGTAAACGGTTATTTCTGTTTCTTAAAAAGTATTGTTAG TGGGCTATTAAACTTGGATTTTTCTTTTTATTAATGCAGTATGTTCTTTTTATTCAAGTATGAACTTGTTGAGAAACTATAGTAATATGA TTTTTAAGAGATTTATGTTCTACTTAAAATGTGAATTGTACTTCTGAGCTGCCTTAATGCAAGGTCATTTATATTTGTTAAGAGGAAATA ATCAAGATCACTCATATCCCAACTGAATCTGAGGTTTTATAAATCCCTCAAACGATTGCTGAGAGCCTGATTGTGGAAAGAAGTGAGATG CACCTTATTTTCAAGAAGTCCTGGGAAGCGCTCTCCTAGCACGTCCATTTCCAGGAGGAGAAGCAAGCAGATGAGAGGTTTTCCATTTTG TCATCCAAGGTAGCTGTGCACTTGCCTTGTTGCTGAAGTTCCAATAATGTGAAAACCAAAGTAGAGGTTTTTTTCTTCTTCTTTTTGTTT TCTATTAATTTCACTTATACCAAAGTGTTTGAAAGTATGAAATGTGTTGCTTCTGAGTTATATAAGGCTACTTCATGACAAGACTGCTTT GTAATATTTCACTTTGTTTTACTACAAATTCAGATCACTTTGTTTTACTATAAATTCAGATTATCCAAATATTTTCCTAATACTATGTGG GAATGCTGATTTTCTTTTGTTACGTAGTGGAAACATTTTGCATTGTTTACATAGTTCTCATGGAACATGGAAATTTTTGAAAGTGATATA TGATACACATTTTTTGTGTATGTATTCTAATTAGTGTGAATAAAGCAGTAACATTAATGCATTTTTTAAGCAGCAAACTTATGTATTTCT CTTGTCTTCCTTAAAAGTGTCCCCATGAACTCAGTGTTTATTCCCTTTTCATTTTGAGTACCTGCTTATATGGTCAGTATGTAACGTTAG CATTGGCTCCTAATGGTAGAATTAGAACAGCAAGATTGTAGAGCTGTAATTGACTCCAGACAACATAGATTTCAGCCACCTCATTCTACA GCTGAGGCCAGGACAATAAATGCCTTTCCCAGACTGGGTAGTGGCAGATCTGGGATGGAATATGGTTTTCTTGATTCCCTTTCAGCCTTC ATTTCTCTCTCTCAGGACTACTACTTTTTAATTACTTTTCACTTAATTTCCCAATACTGATGAAATAAAGAAAAATGAGGGTTATTTATA >7568_7568_5_ATG4B-SEC23IP_ATG4B_chr2_242606253_ENST00000404914_SEC23IP_chr10_121678956_ENST00000369075_length(amino acids)=620AA_BP=242 MDAATLTYDTLRFAEFEDFPETSEPVWILGRKYSIFTEKDEILSDVASRLWFTYRKNFPAIGGTGPTSDTGWGCMLRCGQMIFAQALVCR HLGRDWRWTQRKRQPDSYFSVLNAFIDRKDSYYSIHQIAQMGVGEGKSIGQWYGPNTVAQVLKKLAVFDTWSSLAVHIAMDNTVVMEEIR RLCRTSVPCAGATAFPADSDRHCNGFPAGAEVTNRPSPWRPLVLLIPLRLGLTDINEAYVETLKMPEEPKLTLDESYDLVVENKEVLTLQ ETLEALSLSEYFSTFEKEKIDMESLLMCTVDDLKEMGIPLGPRKKIANFVEHKAAKLKKAASEKKAVAATSTKGQEQSAQKTKDMASLPS ESNEPKRKLPVGACVSSVCVNYESFEVGAGQVSVAYNSLDFEPEIFFALGSPIAMFLTIRGVDRIDENYSLPTCKGFFNIYHPLDPVAYR LEPMIVPDLDLKAVLIPHHKGRKRLHLELKESLSRMGSDLKQGFISSLKSAWQTLNEFARAHTSSTQLQEELEKVANQIKEEEEKQVVEA -------------------------------------------------------------- >7568_7568_6_ATG4B-SEC23IP_ATG4B_chr2_242606253_ENST00000404914_SEC23IP_chr10_121678956_ENST00000543134_length(transcript)=2135nt_BP=835nt GCGCCGGCACACCTATTGGCCCCCGCGGCGTCCCGTCGCCGCGTCGCGTTGCTGGCCCGTCGGAGCGACGCCGCTCGGGTCAGTCGGCGG CCGGACTGGGAAGATGGACGCAGCTACTCTGACCTACGACACTCTCCGGTTTGCTGAGTTTGAAGATTTTCCTGAGACCTCAGAGCCCGT TTGGATACTGGGTAGAAAATACAGCATTTTCACAGAAAAGGACGAGATCTTGTCTGATGTGGCATCTAGACTTTGGTTTACATACAGGAA AAACTTTCCAGCCATTGGGGGGACAGGCCCCACCTCGGACACAGGCTGGGGCTGCATGCTGCGGTGTGGACAGATGATCTTTGCCCAAGC CCTGGTGTGCCGGCACCTAGGCCGAGATTGGAGGTGGACACAAAGGAAGAGGCAGCCAGACAGCTACTTCAGCGTCCTCAACGCATTCAT CGACAGGAAGGACAGTTACTACTCCATTCACCAGATAGCGCAAATGGGAGTTGGCGAAGGCAAGTCCATAGGCCAGTGGTACGGGCCCAA CACTGTCGCCCAGGTCCTGAAGAAGCTTGCTGTCTTCGATACGTGGAGCTCCTTGGCGGTCCACATTGCAATGGACAACACTGTTGTGAT GGAGGAAATCAGAAGGTTGTGCAGGACCAGCGTTCCCTGTGCAGGCGCCACTGCGTTTCCTGCAGATTCCGACCGGCACTGCAACGGATT CCCTGCCGGAGCTGAGGTCACCAACAGGCCGTCGCCATGGAGACCCCTGGTACTTCTCATTCCCCTGCGCCTGGGGCTCACGGACATCAA CGAGGCCTACGTGGAGACGCTGAAGATGCCTGAAGAGCCAAAGCTGACTTTGGATGAGTCGTATGACCTTGTTGTTGAAAATAAAGAAGT CCTAACTTTGCAAGAAACTCTGGAAGCACTTAGCCTCTCTGAATATTTTAGCACTTTTGAAAAGGAAAAGATTGATATGGAGTCCCTGCT TATGTGTACAGTTGATGACCTGAAGGAAATGGGGATACCCCTTGGACCCAGAAAGAAGATAGCTAACTTTGTAGAACATAAAGCAGCCAA ACTGAAAAAAGCAGCGTCAGAAAAGAAGGCAGTGGCGGCCACTTCTACAAAAGGACAAGAGCAAAGTGCCCAGAAGACTAAAGACATGGC TTCCCTCCCCTCAGAATCCAATGAGCCAAAGAGGAAACTTCCAGTTGGTGCTTGCGTGTCTTCTGTGTGTGTGAATTATGAATCTTTTGA AGTTGGCGCCGGACAGGTTTCTGTTGCTTACAACTCATTAGATTTTGAACCAGAGATATTCTTTGCCTTGGGGTCTCCAATTGCTATGTT TCTCACTATTCGAGGAGTTGATAGGATAGATGAGAATTACAGCCTTCCTACCTGTAAAGGGTTCTTCAATATTTATCATCCGCTTGATCC AGTGGCATATAGATTAGAACCTATGATTGTTCCAGATTTGGACCTAAAAGCTGTTCTCATTCCACATCACAAAGGCAGAAAAAGACTTCA TTTAGAATTGAAAGAGAGTCTCTCTCGTATGGGATCTGATTTGAAGCAGGGTTTTATTAGCTCTCTCAAAAGTGCTTGGCAGACATTAAA TGAGTTTGCCCGTGCTCATACGTCTTCAACCCAGTTGCAAGAAGAATTGGAGAAGGTGGCCAATCAGATCAAAGAAGAAGAAGAAAAGCA AGTAGTTGAAGCAGAAAAGGTTGTTGAAAGTCCAGATTTTTCCAAGGATGAGGACTACTTAGGAAAGGTTGGAATGTTAAATGGAGGCCG CCGAATTGACTACGTTCTCCAAGAAAAACCAATAGAGAGTTTTAATGAATACCTTTTCGCTCTTCAGAGTCACTTATGCTATTGGGAATC TGAAGATACTGCTCTGTTACTACTTAAAGAAATTTATCGAACAATGAACATTAGTCCAGAACAGCCCCAGCATTGATCAAACTTCAGTTT TACTGTACTTTCTTGTCTGCACAGAAAGTCCCAGTACAACTTCCATTGCTGAGAAAATCCTCAGAGGACTTTCCCACTTCGCTCCTGTGA >7568_7568_6_ATG4B-SEC23IP_ATG4B_chr2_242606253_ENST00000404914_SEC23IP_chr10_121678956_ENST00000543134_length(amino acids)=620AA_BP=242 MDAATLTYDTLRFAEFEDFPETSEPVWILGRKYSIFTEKDEILSDVASRLWFTYRKNFPAIGGTGPTSDTGWGCMLRCGQMIFAQALVCR HLGRDWRWTQRKRQPDSYFSVLNAFIDRKDSYYSIHQIAQMGVGEGKSIGQWYGPNTVAQVLKKLAVFDTWSSLAVHIAMDNTVVMEEIR RLCRTSVPCAGATAFPADSDRHCNGFPAGAEVTNRPSPWRPLVLLIPLRLGLTDINEAYVETLKMPEEPKLTLDESYDLVVENKEVLTLQ ETLEALSLSEYFSTFEKEKIDMESLLMCTVDDLKEMGIPLGPRKKIANFVEHKAAKLKKAASEKKAVAATSTKGQEQSAQKTKDMASLPS ESNEPKRKLPVGACVSSVCVNYESFEVGAGQVSVAYNSLDFEPEIFFALGSPIAMFLTIRGVDRIDENYSLPTCKGFFNIYHPLDPVAYR LEPMIVPDLDLKAVLIPHHKGRKRLHLELKESLSRMGSDLKQGFISSLKSAWQTLNEFARAHTSSTQLQEELEKVANQIKEEEEKQVVEA -------------------------------------------------------------- >7568_7568_7_ATG4B-SEC23IP_ATG4B_chr2_242606253_ENST00000405546_SEC23IP_chr10_121678956_ENST00000369075_length(transcript)=3946nt_BP=1234nt CTCGCCAGCCGCGGGTTCGGGCGTCTTCGGACCAGCGGGGCGCCGCAGGCCCCTCGCAGCGTCCGTCGGCAGGCGGGCAGACGGGCGGGG GAGTCGCCCCGGCGGGGCAAGTCCGTACCGCGACATGGGCGCGCCGAGCACGTCCGTACCGCAAGATGGCTGCTCGGACGGGGACAGAGC TCGCCTCTGCCGCCTCGACAACTGCTCCTGGGTCCTCTAAGAGGAGGAAGCGCCACCCATGGCACACAGTGTCCCGTCGGACAGCAGAAC CAGCCGTCGTCCCACGACACGACCCCATGCCGCCCGCAGGGCGCCCCGGGGCTCGCGTCGGCCCGGCCGTACGCCAAAATGGCGGCTCCC GCGTATTTCCGCTCGCGCGCCGTATCGTCTTCGCCGCCTGCGCCGGCACACCTATTGGCCCCCGCGGCGTCCCGTCGCCGCGTCGCGTTG CTGGCCCGTCGGAGCGACGCCGCTCGGGTCAGTCGGCGGCCGGACTGGGAAGATGGACGCAGCTACTCTGACCTACGACACTCTCCGGTT TGCTGAGTTTGAAGATTTTCCTGAGACCTCAGAGCCCGTTTGGATACTGGGTAGAAAATACAGCATTTTCACAGAAAAGGACGAGATCTT GTCTGATGTGGCATCTAGACTTTGGTTTACATACAGGAAAAACTTTCCAGCCATTGGGGGGACAGGCCCCACCTCGGACACAGGCTGGGG CTGCATGCTGCGGTGTGGACAGATGATCTTTGCCCAAGCCCTGGTGTGCCGGCACCTAGGCCGAGATTGGAGGTGGACACAAAGGAAGAG GCAGCCAGACAGCTACTTCAGCGTCCTCAACGCATTCATCGACAGGAAGGACAGTTACTACTCCATTCACCAGATAGCGCAAATGGGAGT TGGCGAAGGCAAGTCCATAGGCCAGTGGTACGGGCCCAACACTGTCGCCCAGGTCCTGAAGAAGCTTGCTGTCTTCGATACGTGGAGCTC CTTGGCGGTCCACATTGCAATGGACAACACTGTTGTGATGGAGGAAATCAGAAGGTTGTGCAGGACCAGCGTTCCCTGTGCAGGCGCCAC TGCGTTTCCTGCAGATTCCGACCGGCACTGCAACGGATTCCCTGCCGGAGCTGAGGTCACCAACAGGCCGTCGCCATGGAGACCCCTGGT ACTTCTCATTCCCCTGCGCCTGGGGCTCACGGACATCAACGAGGCCTACGTGGAGACGCTGAAGATGCCTGAAGAGCCAAAGCTGACTTT GGATGAGTCGTATGACCTTGTTGTTGAAAATAAAGAAGTCCTAACTTTGCAAGAAACTCTGGAAGCACTTAGCCTCTCTGAATATTTTAG CACTTTTGAAAAGGAAAAGATTGATATGGAGTCCCTGCTTATGTGTACAGTTGATGACCTGAAGGAAATGGGGATACCCCTTGGACCCAG AAAGAAGATAGCTAACTTTGTAGAACATAAAGCAGCCAAACTGAAAAAAGCAGCGTCAGAAAAGAAGGCAGTGGCGGCCACTTCTACAAA AGGACAAGAGCAAAGTGCCCAGAAGACTAAAGACATGGCTTCCCTCCCCTCAGAATCCAATGAGCCAAAGAGGAAACTTCCAGTTGGTGC TTGCGTGTCTTCTGTGTGTGTGAATTATGAATCTTTTGAAGTTGGCGCCGGACAGGTTTCTGTTGCTTACAACTCATTAGATTTTGAACC AGAGATATTCTTTGCCTTGGGGTCTCCAATTGCTATGTTTCTCACTATTCGAGGAGTTGATAGGATAGATGAGAATTACAGCCTTCCTAC CTGTAAAGGGTTCTTCAATATTTATCATCCGCTTGATCCAGTGGCATATAGATTAGAACCTATGATTGTTCCAGATTTGGACCTAAAAGC TGTTCTCATTCCACATCACAAAGGCAGAAAAAGACTTCATTTAGAATTGAAAGAGAGTCTCTCTCGTATGGGATCTGATTTGAAGCAGGG TTTTATTAGCTCTCTCAAAAGTGCTTGGCAGACATTAAATGAGTTTGCCCGTGCTCATACGTCTTCAACCCAGTTGCAAGAAGAATTGGA GAAGGTGGCCAATCAGATCAAAGAAGAAGAAGAAAAGCAAGTAGTTGAAGCAGAAAAGGTTGTTGAAAGTCCAGATTTTTCCAAGGATGA GGACTACTTAGGAAAGGTTGGAATGTTAAATGGAGGCCGCCGAATTGACTACGTTCTCCAAGAAAAACCAATAGAGAGTTTTAATGAATA CCTTTTCGCTCTTCAGAGTCACTTATGCTATTGGGAATCTGAAGATACTGCTCTGTTACTACTTAAAGAAATTTATCGAACAATGAACAT TAGTCCAGAACAGCCCCAGCATTGATCAAACTTCAGTTTTACTGTACTTTCTTGTCTGCACAGAAAGTCCCAGTACAACTTCCATTGCTG AGAAAATCCTCAGAGGACTTTCCCACTTCGCTCCTGTGATGGATGACAGAAGAGTGATTCATTAACAATTGCTCAGCCACAATTCTCGGA TATAGGGATTCAAAAGACAGGACACAGAACTAACACAGTGAAAAAAATCAGTACCACATTTGGACAGTATAGGTGAGAAAACATAATTAT AAAAATGATGCCATGAAAAATTCCACAGATCAGTTTAGTTGTATAGTTGTCAAAGTTATATGTGATATCAATGAAGAAATATTTGTAGCA TGTAAACGGTTATTTCTGTTTCTTAAAAAGTATTGTTAGTGGGCTATTAAACTTGGATTTTTCTTTTTATTAATGCAGTATGTTCTTTTT ATTCAAGTATGAACTTGTTGAGAAACTATAGTAATATGATTTTTAAGAGATTTATGTTCTACTTAAAATGTGAATTGTACTTCTGAGCTG CCTTAATGCAAGGTCATTTATATTTGTTAAGAGGAAATAATCAAGATCACTCATATCCCAACTGAATCTGAGGTTTTATAAATCCCTCAA ACGATTGCTGAGAGCCTGATTGTGGAAAGAAGTGAGATGCACCTTATTTTCAAGAAGTCCTGGGAAGCGCTCTCCTAGCACGTCCATTTC CAGGAGGAGAAGCAAGCAGATGAGAGGTTTTCCATTTTGTCATCCAAGGTAGCTGTGCACTTGCCTTGTTGCTGAAGTTCCAATAATGTG AAAACCAAAGTAGAGGTTTTTTTCTTCTTCTTTTTGTTTTCTATTAATTTCACTTATACCAAAGTGTTTGAAAGTATGAAATGTGTTGCT TCTGAGTTATATAAGGCTACTTCATGACAAGACTGCTTTGTAATATTTCACTTTGTTTTACTACAAATTCAGATCACTTTGTTTTACTAT AAATTCAGATTATCCAAATATTTTCCTAATACTATGTGGGAATGCTGATTTTCTTTTGTTACGTAGTGGAAACATTTTGCATTGTTTACA TAGTTCTCATGGAACATGGAAATTTTTGAAAGTGATATATGATACACATTTTTTGTGTATGTATTCTAATTAGTGTGAATAAAGCAGTAA CATTAATGCATTTTTTAAGCAGCAAACTTATGTATTTCTCTTGTCTTCCTTAAAAGTGTCCCCATGAACTCAGTGTTTATTCCCTTTTCA TTTTGAGTACCTGCTTATATGGTCAGTATGTAACGTTAGCATTGGCTCCTAATGGTAGAATTAGAACAGCAAGATTGTAGAGCTGTAATT GACTCCAGACAACATAGATTTCAGCCACCTCATTCTACAGCTGAGGCCAGGACAATAAATGCCTTTCCCAGACTGGGTAGTGGCAGATCT GGGATGGAATATGGTTTTCTTGATTCCCTTTCAGCCTTCATTTCTCTCTCTCAGGACTACTACTTTTTAATTACTTTTCACTTAATTTCC >7568_7568_7_ATG4B-SEC23IP_ATG4B_chr2_242606253_ENST00000405546_SEC23IP_chr10_121678956_ENST00000369075_length(amino acids)=708AA_BP=330 MAHSVPSDSRTSRRPTTRPHAARRAPRGSRRPGRTPKWRLPRISARAPYRLRRLRRHTYWPPRRPVAASRCWPVGATPLGSVGGRTGKMD AATLTYDTLRFAEFEDFPETSEPVWILGRKYSIFTEKDEILSDVASRLWFTYRKNFPAIGGTGPTSDTGWGCMLRCGQMIFAQALVCRHL GRDWRWTQRKRQPDSYFSVLNAFIDRKDSYYSIHQIAQMGVGEGKSIGQWYGPNTVAQVLKKLAVFDTWSSLAVHIAMDNTVVMEEIRRL CRTSVPCAGATAFPADSDRHCNGFPAGAEVTNRPSPWRPLVLLIPLRLGLTDINEAYVETLKMPEEPKLTLDESYDLVVENKEVLTLQET LEALSLSEYFSTFEKEKIDMESLLMCTVDDLKEMGIPLGPRKKIANFVEHKAAKLKKAASEKKAVAATSTKGQEQSAQKTKDMASLPSES NEPKRKLPVGACVSSVCVNYESFEVGAGQVSVAYNSLDFEPEIFFALGSPIAMFLTIRGVDRIDENYSLPTCKGFFNIYHPLDPVAYRLE PMIVPDLDLKAVLIPHHKGRKRLHLELKESLSRMGSDLKQGFISSLKSAWQTLNEFARAHTSSTQLQEELEKVANQIKEEEEKQVVEAEK -------------------------------------------------------------- >7568_7568_8_ATG4B-SEC23IP_ATG4B_chr2_242606253_ENST00000405546_SEC23IP_chr10_121678956_ENST00000543134_length(transcript)=2534nt_BP=1234nt CTCGCCAGCCGCGGGTTCGGGCGTCTTCGGACCAGCGGGGCGCCGCAGGCCCCTCGCAGCGTCCGTCGGCAGGCGGGCAGACGGGCGGGG GAGTCGCCCCGGCGGGGCAAGTCCGTACCGCGACATGGGCGCGCCGAGCACGTCCGTACCGCAAGATGGCTGCTCGGACGGGGACAGAGC TCGCCTCTGCCGCCTCGACAACTGCTCCTGGGTCCTCTAAGAGGAGGAAGCGCCACCCATGGCACACAGTGTCCCGTCGGACAGCAGAAC CAGCCGTCGTCCCACGACACGACCCCATGCCGCCCGCAGGGCGCCCCGGGGCTCGCGTCGGCCCGGCCGTACGCCAAAATGGCGGCTCCC GCGTATTTCCGCTCGCGCGCCGTATCGTCTTCGCCGCCTGCGCCGGCACACCTATTGGCCCCCGCGGCGTCCCGTCGCCGCGTCGCGTTG CTGGCCCGTCGGAGCGACGCCGCTCGGGTCAGTCGGCGGCCGGACTGGGAAGATGGACGCAGCTACTCTGACCTACGACACTCTCCGGTT TGCTGAGTTTGAAGATTTTCCTGAGACCTCAGAGCCCGTTTGGATACTGGGTAGAAAATACAGCATTTTCACAGAAAAGGACGAGATCTT GTCTGATGTGGCATCTAGACTTTGGTTTACATACAGGAAAAACTTTCCAGCCATTGGGGGGACAGGCCCCACCTCGGACACAGGCTGGGG CTGCATGCTGCGGTGTGGACAGATGATCTTTGCCCAAGCCCTGGTGTGCCGGCACCTAGGCCGAGATTGGAGGTGGACACAAAGGAAGAG GCAGCCAGACAGCTACTTCAGCGTCCTCAACGCATTCATCGACAGGAAGGACAGTTACTACTCCATTCACCAGATAGCGCAAATGGGAGT TGGCGAAGGCAAGTCCATAGGCCAGTGGTACGGGCCCAACACTGTCGCCCAGGTCCTGAAGAAGCTTGCTGTCTTCGATACGTGGAGCTC CTTGGCGGTCCACATTGCAATGGACAACACTGTTGTGATGGAGGAAATCAGAAGGTTGTGCAGGACCAGCGTTCCCTGTGCAGGCGCCAC TGCGTTTCCTGCAGATTCCGACCGGCACTGCAACGGATTCCCTGCCGGAGCTGAGGTCACCAACAGGCCGTCGCCATGGAGACCCCTGGT ACTTCTCATTCCCCTGCGCCTGGGGCTCACGGACATCAACGAGGCCTACGTGGAGACGCTGAAGATGCCTGAAGAGCCAAAGCTGACTTT GGATGAGTCGTATGACCTTGTTGTTGAAAATAAAGAAGTCCTAACTTTGCAAGAAACTCTGGAAGCACTTAGCCTCTCTGAATATTTTAG CACTTTTGAAAAGGAAAAGATTGATATGGAGTCCCTGCTTATGTGTACAGTTGATGACCTGAAGGAAATGGGGATACCCCTTGGACCCAG AAAGAAGATAGCTAACTTTGTAGAACATAAAGCAGCCAAACTGAAAAAAGCAGCGTCAGAAAAGAAGGCAGTGGCGGCCACTTCTACAAA AGGACAAGAGCAAAGTGCCCAGAAGACTAAAGACATGGCTTCCCTCCCCTCAGAATCCAATGAGCCAAAGAGGAAACTTCCAGTTGGTGC TTGCGTGTCTTCTGTGTGTGTGAATTATGAATCTTTTGAAGTTGGCGCCGGACAGGTTTCTGTTGCTTACAACTCATTAGATTTTGAACC AGAGATATTCTTTGCCTTGGGGTCTCCAATTGCTATGTTTCTCACTATTCGAGGAGTTGATAGGATAGATGAGAATTACAGCCTTCCTAC CTGTAAAGGGTTCTTCAATATTTATCATCCGCTTGATCCAGTGGCATATAGATTAGAACCTATGATTGTTCCAGATTTGGACCTAAAAGC TGTTCTCATTCCACATCACAAAGGCAGAAAAAGACTTCATTTAGAATTGAAAGAGAGTCTCTCTCGTATGGGATCTGATTTGAAGCAGGG TTTTATTAGCTCTCTCAAAAGTGCTTGGCAGACATTAAATGAGTTTGCCCGTGCTCATACGTCTTCAACCCAGTTGCAAGAAGAATTGGA GAAGGTGGCCAATCAGATCAAAGAAGAAGAAGAAAAGCAAGTAGTTGAAGCAGAAAAGGTTGTTGAAAGTCCAGATTTTTCCAAGGATGA GGACTACTTAGGAAAGGTTGGAATGTTAAATGGAGGCCGCCGAATTGACTACGTTCTCCAAGAAAAACCAATAGAGAGTTTTAATGAATA CCTTTTCGCTCTTCAGAGTCACTTATGCTATTGGGAATCTGAAGATACTGCTCTGTTACTACTTAAAGAAATTTATCGAACAATGAACAT TAGTCCAGAACAGCCCCAGCATTGATCAAACTTCAGTTTTACTGTACTTTCTTGTCTGCACAGAAAGTCCCAGTACAACTTCCATTGCTG AGAAAATCCTCAGAGGACTTTCCCACTTCGCTCCTGTGATGGATGACAGAAGAGTGATTCATTAACAATTGCTCAGCCACAATTCTCGGA >7568_7568_8_ATG4B-SEC23IP_ATG4B_chr2_242606253_ENST00000405546_SEC23IP_chr10_121678956_ENST00000543134_length(amino acids)=708AA_BP=330 MAHSVPSDSRTSRRPTTRPHAARRAPRGSRRPGRTPKWRLPRISARAPYRLRRLRRHTYWPPRRPVAASRCWPVGATPLGSVGGRTGKMD AATLTYDTLRFAEFEDFPETSEPVWILGRKYSIFTEKDEILSDVASRLWFTYRKNFPAIGGTGPTSDTGWGCMLRCGQMIFAQALVCRHL GRDWRWTQRKRQPDSYFSVLNAFIDRKDSYYSIHQIAQMGVGEGKSIGQWYGPNTVAQVLKKLAVFDTWSSLAVHIAMDNTVVMEEIRRL CRTSVPCAGATAFPADSDRHCNGFPAGAEVTNRPSPWRPLVLLIPLRLGLTDINEAYVETLKMPEEPKLTLDESYDLVVENKEVLTLQET LEALSLSEYFSTFEKEKIDMESLLMCTVDDLKEMGIPLGPRKKIANFVEHKAAKLKKAASEKKAVAATSTKGQEQSAQKTKDMASLPSES NEPKRKLPVGACVSSVCVNYESFEVGAGQVSVAYNSLDFEPEIFFALGSPIAMFLTIRGVDRIDENYSLPTCKGFFNIYHPLDPVAYRLE PMIVPDLDLKAVLIPHHKGRKRLHLELKESLSRMGSDLKQGFISSLKSAWQTLNEFARAHTSSTQLQEELEKVANQIKEEEEKQVVEAEK -------------------------------------------------------------- >7568_7568_9_ATG4B-SEC23IP_ATG4B_chr2_242606253_ENST00000474739_SEC23IP_chr10_121678956_ENST00000369075_length(transcript)=3557nt_BP=845nt AGTCGGCGGCCGGACTGGGAAGATGGACGCAGCTACTCTGACCTACGACACTCTCCGGTTTGCTGAGTTTGAAGATTTTCCTGAGACCTC AGAGCCCGTTTGGATACTGGGTAGAAAATACAGCATTTTCACAGAAAAGGACGAGATCTTGTCTGATGTGGCATCTAGACTTTGGTTTAC ATACAGGAAAAACTTTCCAGCCATTGCCATTCATCATTGTTGTATACCCTGGAGCTGGAAGGAGATGGGGACTGGTTCTCAGCCTTGCCT CTCACCGGCGGAGAACTGAGGCCGGAGGGGGGACAGGCCCCACCTCGGACACAGGCTGGGGCTGCATGCTGCGGTGTGGACAGATGATCT TTGCCCAAGCCCTGGTGTGCCGGCACCTAGGCCGAGATTGGAGGTGGACACAAAGGAAGAGGCAGCCAGACAGCTACTTCAGCGTCCTCA ACGCATTCATCGACAGGAAGGACAGTTACTACTCCATTCACCAGATAGCGCAAATGGGAGTTGGCGAAGGCAAGTCCATAGGCCAGTGGT ACGGGCCCAACACTGTCGCCCAGGTCCTGAAGAAGCTTGCTGTCTTCGATACGTGGAGCTCCTTGGCGGTCCACATTGCAATGGACAACA CTGTTGTGATGGAGGAAATCAGAAGGTTGTGCAGGACCAGCGTTCCCTGTGCAGGCGCCACTGCGTTTCCTGCAGATTCCGACCGGCACT GCAACGGATTCCCTGCCGGAGCTGAGGTCACCAACAGGCCGTCGCCATGGAGACCCCTGGTACTTCTCATTCCCCTGCGCCTGGGGCTCA CGGACATCAACGAGGCCTACGTGGAGACGCTGAAGATGCCTGAAGAGCCAAAGCTGACTTTGGATGAGTCGTATGACCTTGTTGTTGAAA ATAAAGAAGTCCTAACTTTGCAAGAAACTCTGGAAGCACTTAGCCTCTCTGAATATTTTAGCACTTTTGAAAAGGAAAAGATTGATATGG AGTCCCTGCTTATGTGTACAGTTGATGACCTGAAGGAAATGGGGATACCCCTTGGACCCAGAAAGAAGATAGCTAACTTTGTAGAACATA AAGCAGCCAAACTGAAAAAAGCAGCGTCAGAAAAGAAGGCAGTGGCGGCCACTTCTACAAAAGGACAAGAGCAAAGTGCCCAGAAGACTA AAGACATGGCTTCCCTCCCCTCAGAATCCAATGAGCCAAAGAGGAAACTTCCAGTTGGTGCTTGCGTGTCTTCTGTGTGTGTGAATTATG AATCTTTTGAAGTTGGCGCCGGACAGGTTTCTGTTGCTTACAACTCATTAGATTTTGAACCAGAGATATTCTTTGCCTTGGGGTCTCCAA TTGCTATGTTTCTCACTATTCGAGGAGTTGATAGGATAGATGAGAATTACAGCCTTCCTACCTGTAAAGGGTTCTTCAATATTTATCATC CGCTTGATCCAGTGGCATATAGATTAGAACCTATGATTGTTCCAGATTTGGACCTAAAAGCTGTTCTCATTCCACATCACAAAGGCAGAA AAAGACTTCATTTAGAATTGAAAGAGAGTCTCTCTCGTATGGGATCTGATTTGAAGCAGGGTTTTATTAGCTCTCTCAAAAGTGCTTGGC AGACATTAAATGAGTTTGCCCGTGCTCATACGTCTTCAACCCAGTTGCAAGAAGAATTGGAGAAGGTGGCCAATCAGATCAAAGAAGAAG AAGAAAAGCAAGTAGTTGAAGCAGAAAAGGTTGTTGAAAGTCCAGATTTTTCCAAGGATGAGGACTACTTAGGAAAGGTTGGAATGTTAA ATGGAGGCCGCCGAATTGACTACGTTCTCCAAGAAAAACCAATAGAGAGTTTTAATGAATACCTTTTCGCTCTTCAGAGTCACTTATGCT ATTGGGAATCTGAAGATACTGCTCTGTTACTACTTAAAGAAATTTATCGAACAATGAACATTAGTCCAGAACAGCCCCAGCATTGATCAA ACTTCAGTTTTACTGTACTTTCTTGTCTGCACAGAAAGTCCCAGTACAACTTCCATTGCTGAGAAAATCCTCAGAGGACTTTCCCACTTC GCTCCTGTGATGGATGACAGAAGAGTGATTCATTAACAATTGCTCAGCCACAATTCTCGGATATAGGGATTCAAAAGACAGGACACAGAA CTAACACAGTGAAAAAAATCAGTACCACATTTGGACAGTATAGGTGAGAAAACATAATTATAAAAATGATGCCATGAAAAATTCCACAGA TCAGTTTAGTTGTATAGTTGTCAAAGTTATATGTGATATCAATGAAGAAATATTTGTAGCATGTAAACGGTTATTTCTGTTTCTTAAAAA GTATTGTTAGTGGGCTATTAAACTTGGATTTTTCTTTTTATTAATGCAGTATGTTCTTTTTATTCAAGTATGAACTTGTTGAGAAACTAT AGTAATATGATTTTTAAGAGATTTATGTTCTACTTAAAATGTGAATTGTACTTCTGAGCTGCCTTAATGCAAGGTCATTTATATTTGTTA AGAGGAAATAATCAAGATCACTCATATCCCAACTGAATCTGAGGTTTTATAAATCCCTCAAACGATTGCTGAGAGCCTGATTGTGGAAAG AAGTGAGATGCACCTTATTTTCAAGAAGTCCTGGGAAGCGCTCTCCTAGCACGTCCATTTCCAGGAGGAGAAGCAAGCAGATGAGAGGTT TTCCATTTTGTCATCCAAGGTAGCTGTGCACTTGCCTTGTTGCTGAAGTTCCAATAATGTGAAAACCAAAGTAGAGGTTTTTTTCTTCTT CTTTTTGTTTTCTATTAATTTCACTTATACCAAAGTGTTTGAAAGTATGAAATGTGTTGCTTCTGAGTTATATAAGGCTACTTCATGACA AGACTGCTTTGTAATATTTCACTTTGTTTTACTACAAATTCAGATCACTTTGTTTTACTATAAATTCAGATTATCCAAATATTTTCCTAA TACTATGTGGGAATGCTGATTTTCTTTTGTTACGTAGTGGAAACATTTTGCATTGTTTACATAGTTCTCATGGAACATGGAAATTTTTGA AAGTGATATATGATACACATTTTTTGTGTATGTATTCTAATTAGTGTGAATAAAGCAGTAACATTAATGCATTTTTTAAGCAGCAAACTT ATGTATTTCTCTTGTCTTCCTTAAAAGTGTCCCCATGAACTCAGTGTTTATTCCCTTTTCATTTTGAGTACCTGCTTATATGGTCAGTAT GTAACGTTAGCATTGGCTCCTAATGGTAGAATTAGAACAGCAAGATTGTAGAGCTGTAATTGACTCCAGACAACATAGATTTCAGCCACC TCATTCTACAGCTGAGGCCAGGACAATAAATGCCTTTCCCAGACTGGGTAGTGGCAGATCTGGGATGGAATATGGTTTTCTTGATTCCCT TTCAGCCTTCATTTCTCTCTCTCAGGACTACTACTTTTTAATTACTTTTCACTTAATTTCCCAATACTGATGAAATAAAGAAAAATGAGG >7568_7568_9_ATG4B-SEC23IP_ATG4B_chr2_242606253_ENST00000474739_SEC23IP_chr10_121678956_ENST00000369075_length(amino acids)=638AA_BP=260 MLSLKIFLRPQSPFGYWVENTAFSQKRTRSCLMWHLDFGLHTGKTFQPLPFIIVVYPGAGRRWGLVLSLASHRRRTEAGGGTGPTSDTGW GCMLRCGQMIFAQALVCRHLGRDWRWTQRKRQPDSYFSVLNAFIDRKDSYYSIHQIAQMGVGEGKSIGQWYGPNTVAQVLKKLAVFDTWS SLAVHIAMDNTVVMEEIRRLCRTSVPCAGATAFPADSDRHCNGFPAGAEVTNRPSPWRPLVLLIPLRLGLTDINEAYVETLKMPEEPKLT LDESYDLVVENKEVLTLQETLEALSLSEYFSTFEKEKIDMESLLMCTVDDLKEMGIPLGPRKKIANFVEHKAAKLKKAASEKKAVAATST KGQEQSAQKTKDMASLPSESNEPKRKLPVGACVSSVCVNYESFEVGAGQVSVAYNSLDFEPEIFFALGSPIAMFLTIRGVDRIDENYSLP TCKGFFNIYHPLDPVAYRLEPMIVPDLDLKAVLIPHHKGRKRLHLELKESLSRMGSDLKQGFISSLKSAWQTLNEFARAHTSSTQLQEEL EKVANQIKEEEEKQVVEAEKVVESPDFSKDEDYLGKVGMLNGGRRIDYVLQEKPIESFNEYLFALQSHLCYWESEDTALLLLKEIYRTMN -------------------------------------------------------------- >7568_7568_10_ATG4B-SEC23IP_ATG4B_chr2_242606253_ENST00000474739_SEC23IP_chr10_121678956_ENST00000543134_length(transcript)=2145nt_BP=845nt AGTCGGCGGCCGGACTGGGAAGATGGACGCAGCTACTCTGACCTACGACACTCTCCGGTTTGCTGAGTTTGAAGATTTTCCTGAGACCTC AGAGCCCGTTTGGATACTGGGTAGAAAATACAGCATTTTCACAGAAAAGGACGAGATCTTGTCTGATGTGGCATCTAGACTTTGGTTTAC ATACAGGAAAAACTTTCCAGCCATTGCCATTCATCATTGTTGTATACCCTGGAGCTGGAAGGAGATGGGGACTGGTTCTCAGCCTTGCCT CTCACCGGCGGAGAACTGAGGCCGGAGGGGGGACAGGCCCCACCTCGGACACAGGCTGGGGCTGCATGCTGCGGTGTGGACAGATGATCT TTGCCCAAGCCCTGGTGTGCCGGCACCTAGGCCGAGATTGGAGGTGGACACAAAGGAAGAGGCAGCCAGACAGCTACTTCAGCGTCCTCA ACGCATTCATCGACAGGAAGGACAGTTACTACTCCATTCACCAGATAGCGCAAATGGGAGTTGGCGAAGGCAAGTCCATAGGCCAGTGGT ACGGGCCCAACACTGTCGCCCAGGTCCTGAAGAAGCTTGCTGTCTTCGATACGTGGAGCTCCTTGGCGGTCCACATTGCAATGGACAACA CTGTTGTGATGGAGGAAATCAGAAGGTTGTGCAGGACCAGCGTTCCCTGTGCAGGCGCCACTGCGTTTCCTGCAGATTCCGACCGGCACT GCAACGGATTCCCTGCCGGAGCTGAGGTCACCAACAGGCCGTCGCCATGGAGACCCCTGGTACTTCTCATTCCCCTGCGCCTGGGGCTCA CGGACATCAACGAGGCCTACGTGGAGACGCTGAAGATGCCTGAAGAGCCAAAGCTGACTTTGGATGAGTCGTATGACCTTGTTGTTGAAA ATAAAGAAGTCCTAACTTTGCAAGAAACTCTGGAAGCACTTAGCCTCTCTGAATATTTTAGCACTTTTGAAAAGGAAAAGATTGATATGG AGTCCCTGCTTATGTGTACAGTTGATGACCTGAAGGAAATGGGGATACCCCTTGGACCCAGAAAGAAGATAGCTAACTTTGTAGAACATA AAGCAGCCAAACTGAAAAAAGCAGCGTCAGAAAAGAAGGCAGTGGCGGCCACTTCTACAAAAGGACAAGAGCAAAGTGCCCAGAAGACTA AAGACATGGCTTCCCTCCCCTCAGAATCCAATGAGCCAAAGAGGAAACTTCCAGTTGGTGCTTGCGTGTCTTCTGTGTGTGTGAATTATG AATCTTTTGAAGTTGGCGCCGGACAGGTTTCTGTTGCTTACAACTCATTAGATTTTGAACCAGAGATATTCTTTGCCTTGGGGTCTCCAA TTGCTATGTTTCTCACTATTCGAGGAGTTGATAGGATAGATGAGAATTACAGCCTTCCTACCTGTAAAGGGTTCTTCAATATTTATCATC CGCTTGATCCAGTGGCATATAGATTAGAACCTATGATTGTTCCAGATTTGGACCTAAAAGCTGTTCTCATTCCACATCACAAAGGCAGAA AAAGACTTCATTTAGAATTGAAAGAGAGTCTCTCTCGTATGGGATCTGATTTGAAGCAGGGTTTTATTAGCTCTCTCAAAAGTGCTTGGC AGACATTAAATGAGTTTGCCCGTGCTCATACGTCTTCAACCCAGTTGCAAGAAGAATTGGAGAAGGTGGCCAATCAGATCAAAGAAGAAG AAGAAAAGCAAGTAGTTGAAGCAGAAAAGGTTGTTGAAAGTCCAGATTTTTCCAAGGATGAGGACTACTTAGGAAAGGTTGGAATGTTAA ATGGAGGCCGCCGAATTGACTACGTTCTCCAAGAAAAACCAATAGAGAGTTTTAATGAATACCTTTTCGCTCTTCAGAGTCACTTATGCT ATTGGGAATCTGAAGATACTGCTCTGTTACTACTTAAAGAAATTTATCGAACAATGAACATTAGTCCAGAACAGCCCCAGCATTGATCAA ACTTCAGTTTTACTGTACTTTCTTGTCTGCACAGAAAGTCCCAGTACAACTTCCATTGCTGAGAAAATCCTCAGAGGACTTTCCCACTTC >7568_7568_10_ATG4B-SEC23IP_ATG4B_chr2_242606253_ENST00000474739_SEC23IP_chr10_121678956_ENST00000543134_length(amino acids)=638AA_BP=260 MLSLKIFLRPQSPFGYWVENTAFSQKRTRSCLMWHLDFGLHTGKTFQPLPFIIVVYPGAGRRWGLVLSLASHRRRTEAGGGTGPTSDTGW GCMLRCGQMIFAQALVCRHLGRDWRWTQRKRQPDSYFSVLNAFIDRKDSYYSIHQIAQMGVGEGKSIGQWYGPNTVAQVLKKLAVFDTWS SLAVHIAMDNTVVMEEIRRLCRTSVPCAGATAFPADSDRHCNGFPAGAEVTNRPSPWRPLVLLIPLRLGLTDINEAYVETLKMPEEPKLT LDESYDLVVENKEVLTLQETLEALSLSEYFSTFEKEKIDMESLLMCTVDDLKEMGIPLGPRKKIANFVEHKAAKLKKAASEKKAVAATST KGQEQSAQKTKDMASLPSESNEPKRKLPVGACVSSVCVNYESFEVGAGQVSVAYNSLDFEPEIFFALGSPIAMFLTIRGVDRIDENYSLP TCKGFFNIYHPLDPVAYRLEPMIVPDLDLKAVLIPHHKGRKRLHLELKESLSRMGSDLKQGFISSLKSAWQTLNEFARAHTSSTQLQEEL EKVANQIKEEEEKQVVEAEKVVESPDFSKDEDYLGKVGMLNGGRRIDYVLQEKPIESFNEYLFALQSHLCYWESEDTALLLLKEIYRTMN -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for ATG4B-SEC23IP |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| Tgene | SEC23IP | chr2:242606253 | chr10:121678956 | ENST00000369075 | 9 | 19 | 1_367 | 624.0 | 1443.0 | SEC23A |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for ATG4B-SEC23IP |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for ATG4B-SEC23IP |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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