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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ATP11B-IVNS1ABP (FusionGDB2 ID:HG23200TG10625)

Fusion Gene Summary for ATP11B-IVNS1ABP

check button Fusion gene summary
Fusion gene informationFusion gene name: ATP11B-IVNS1ABP
Fusion gene ID: hg23200tg10625
HgeneTgene
Gene symbol

ATP11B

IVNS1ABP

Gene ID

23200

10625

Gene nameATPase phospholipid transporting 11B (putative)influenza virus NS1A binding protein
SynonymsATPIF|ATPIRARA3|FLARA3|HSPC068|KLHL39|ND1|NS-1|NS1-BP|NS1BP
Cytomap('ATP11B')('IVNS1ABP')

3q26.33

1q25.3

Type of geneprotein-codingprotein-coding
Descriptionprobable phospholipid-transporting ATPase IFATPase IRATPase, class VI, type 11BP4-ATPase flippase complex alpha subunit ATP11Btruncated ATPase 11B proteininfluenza virus NS1A-binding proteinNCX downstream gene 1NS1-binding proteinaryl hydrocarbon receptor-associated 3aryl hydrocarbon receptor-associated protein 3kelch-like family member 39kelch-like protein 39
Modification date2020031320200320
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000482794, ENST00000323116, 
ENST00000493826, 
Fusion gene scores* DoF score20 X 15 X 10=300017 X 9 X 9=1377
# samples 2218
** MAII scorelog2(22/3000*10)=-3.76938707185858
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(18/1377*10)=-2.93545974780529
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ATP11B [Title/Abstract] AND IVNS1ABP [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointATP11B(182554258)-IVNS1ABP(185270695), # samples:1
Anticipated loss of major functional domain due to fusion event.ATP11B-IVNS1ABP seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ATP11B-IVNS1ABP seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ATP11B-IVNS1ABP seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
ATP11B-IVNS1ABP seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
ATP11B-IVNS1ABP seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across ATP11B (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across IVNS1ABP (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4Non-Cancer135NATP11Bchr3

182554258

+IVNS1ABPchr1

185270695

-


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Fusion Gene ORF analysis for ATP11B-IVNS1ABP

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000482794ENST00000367498ATP11Bchr3

182554258

+IVNS1ABPchr1

185270695

-
3UTR-5UTRENST00000482794ENST00000392007ATP11Bchr3

182554258

+IVNS1ABPchr1

185270695

-
3UTR-5UTRENST00000482794ENST00000459929ATP11Bchr3

182554258

+IVNS1ABPchr1

185270695

-
3UTR-intronENST00000482794ENST00000367497ATP11Bchr3

182554258

+IVNS1ABPchr1

185270695

-
5CDS-5UTRENST00000323116ENST00000392007ATP11Bchr3

182554258

+IVNS1ABPchr1

185270695

-
5CDS-5UTRENST00000323116ENST00000459929ATP11Bchr3

182554258

+IVNS1ABPchr1

185270695

-
5CDS-5UTRENST00000493826ENST00000392007ATP11Bchr3

182554258

+IVNS1ABPchr1

185270695

-
5CDS-5UTRENST00000493826ENST00000459929ATP11Bchr3

182554258

+IVNS1ABPchr1

185270695

-
5CDS-intronENST00000323116ENST00000367497ATP11Bchr3

182554258

+IVNS1ABPchr1

185270695

-
5CDS-intronENST00000493826ENST00000367497ATP11Bchr3

182554258

+IVNS1ABPchr1

185270695

-
Frame-shiftENST00000493826ENST00000367498ATP11Bchr3

182554258

+IVNS1ABPchr1

185270695

-
In-frameENST00000323116ENST00000367498ATP11Bchr3

182554258

+IVNS1ABPchr1

185270695

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000323116ATP11Bchr3182554258+ENST00000367498IVNS1ABPchr1185270695-36238122061975589

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000323116ENST00000367498ATP11Bchr3182554258+IVNS1ABPchr1185270695-0.0003210580.99967897

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Fusion Genomic Features for ATP11B-IVNS1ABP


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for ATP11B-IVNS1ABP


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:182554258/chr1:185270695)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneATP11Bchr3:182554258chr1:185270695ENST00000323116+6301_551841178.0Topological domainCytoplasmic
HgeneATP11Bchr3:182554258chr1:185270695ENST00000323116+63078_821841178.0Topological domainExtracellular
HgeneATP11Bchr3:182554258chr1:185270695ENST00000323116+63056_771841178.0TransmembraneHelical
HgeneATP11Bchr3:182554258chr1:185270695ENST00000323116+63083_1041841178.0TransmembraneHelical
TgeneIVNS1ABPchr3:182554258chr1:185270695ENST00000367498715369_415255643.0RepeatNote=Kelch 1
TgeneIVNS1ABPchr3:182554258chr1:185270695ENST00000367498715416_463255643.0RepeatNote=Kelch 2
TgeneIVNS1ABPchr3:182554258chr1:185270695ENST00000367498715465_512255643.0RepeatNote=Kelch 3
TgeneIVNS1ABPchr3:182554258chr1:185270695ENST00000367498715513_559255643.0RepeatNote=Kelch 4
TgeneIVNS1ABPchr3:182554258chr1:185270695ENST00000367498715560_606255643.0RepeatNote=Kelch 5
TgeneIVNS1ABPchr3:182554258chr1:185270695ENST00000367498715608_642255643.0RepeatNote=Kelch 6

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneATP11Bchr3:182554258chr1:185270695ENST00000323116+6301021_10251841178.0Topological domainCytoplasmic
HgeneATP11Bchr3:182554258chr1:185270695ENST00000323116+6301048_10651841178.0Topological domainExtracellular
HgeneATP11Bchr3:182554258chr1:185270695ENST00000323116+630105_2891841178.0Topological domainCytoplasmic
HgeneATP11Bchr3:182554258chr1:185270695ENST00000323116+6301091_11771841178.0Topological domainCytoplasmic
HgeneATP11Bchr3:182554258chr1:185270695ENST00000323116+630312_3411841178.0Topological domainExtracellular
HgeneATP11Bchr3:182554258chr1:185270695ENST00000323116+630360_8761841178.0Topological domainCytoplasmic
HgeneATP11Bchr3:182554258chr1:185270695ENST00000323116+630899_9101841178.0Topological domainExtracellular
HgeneATP11Bchr3:182554258chr1:185270695ENST00000323116+630931_9601841178.0Topological domainCytoplasmic
HgeneATP11Bchr3:182554258chr1:185270695ENST00000323116+630983_9971841178.0Topological domainExtracellular
HgeneATP11Bchr3:182554258chr1:185270695ENST00000493826+161021_10250196.0Topological domainCytoplasmic
HgeneATP11Bchr3:182554258chr1:185270695ENST00000493826+161048_10650196.0Topological domainExtracellular
HgeneATP11Bchr3:182554258chr1:185270695ENST00000493826+16105_2890196.0Topological domainCytoplasmic
HgeneATP11Bchr3:182554258chr1:185270695ENST00000493826+161091_11770196.0Topological domainCytoplasmic
HgeneATP11Bchr3:182554258chr1:185270695ENST00000493826+161_550196.0Topological domainCytoplasmic
HgeneATP11Bchr3:182554258chr1:185270695ENST00000493826+16312_3410196.0Topological domainExtracellular
HgeneATP11Bchr3:182554258chr1:185270695ENST00000493826+16360_8760196.0Topological domainCytoplasmic
HgeneATP11Bchr3:182554258chr1:185270695ENST00000493826+1678_820196.0Topological domainExtracellular
HgeneATP11Bchr3:182554258chr1:185270695ENST00000493826+16899_9100196.0Topological domainExtracellular
HgeneATP11Bchr3:182554258chr1:185270695ENST00000493826+16931_9600196.0Topological domainCytoplasmic
HgeneATP11Bchr3:182554258chr1:185270695ENST00000493826+16983_9970196.0Topological domainExtracellular
HgeneATP11Bchr3:182554258chr1:185270695ENST00000323116+6301026_10471841178.0TransmembraneHelical
HgeneATP11Bchr3:182554258chr1:185270695ENST00000323116+6301066_10901841178.0TransmembraneHelical
HgeneATP11Bchr3:182554258chr1:185270695ENST00000323116+630290_3111841178.0TransmembraneHelical
HgeneATP11Bchr3:182554258chr1:185270695ENST00000323116+630342_3591841178.0TransmembraneHelical
HgeneATP11Bchr3:182554258chr1:185270695ENST00000323116+630877_8981841178.0TransmembraneHelical
HgeneATP11Bchr3:182554258chr1:185270695ENST00000323116+630911_9301841178.0TransmembraneHelical
HgeneATP11Bchr3:182554258chr1:185270695ENST00000323116+630961_9821841178.0TransmembraneHelical
HgeneATP11Bchr3:182554258chr1:185270695ENST00000323116+630998_10201841178.0TransmembraneHelical
HgeneATP11Bchr3:182554258chr1:185270695ENST00000493826+161026_10470196.0TransmembraneHelical
HgeneATP11Bchr3:182554258chr1:185270695ENST00000493826+161066_10900196.0TransmembraneHelical
HgeneATP11Bchr3:182554258chr1:185270695ENST00000493826+16290_3110196.0TransmembraneHelical
HgeneATP11Bchr3:182554258chr1:185270695ENST00000493826+16342_3590196.0TransmembraneHelical
HgeneATP11Bchr3:182554258chr1:185270695ENST00000493826+1656_770196.0TransmembraneHelical
HgeneATP11Bchr3:182554258chr1:185270695ENST00000493826+1683_1040196.0TransmembraneHelical
HgeneATP11Bchr3:182554258chr1:185270695ENST00000493826+16877_8980196.0TransmembraneHelical
HgeneATP11Bchr3:182554258chr1:185270695ENST00000493826+16911_9300196.0TransmembraneHelical
HgeneATP11Bchr3:182554258chr1:185270695ENST00000493826+16961_9820196.0TransmembraneHelical
HgeneATP11Bchr3:182554258chr1:185270695ENST00000493826+16998_10200196.0TransmembraneHelical
TgeneIVNS1ABPchr3:182554258chr1:185270695ENST00000367498715134_233255643.0DomainNote=BACK
TgeneIVNS1ABPchr3:182554258chr1:185270695ENST0000036749871532_99255643.0DomainBTB


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Fusion Gene Sequence for ATP11B-IVNS1ABP


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>7731_7731_1_ATP11B-IVNS1ABP_ATP11B_chr3_182554258_ENST00000323116_IVNS1ABP_chr1_185270695_ENST00000367498_length(transcript)=3623nt_BP=812nt
GGTCAATAATGAAGGTGGCTGCGGCGCGGCGGCAGGCTCAGCTGCGCCGGGCGGGGGCGGCGCCGGGGCCGCGCCTGTAGGACTCGGGGC
CGACGCCGCGGGATGGGGACGCGGCGCGGGGAGTGAGGCAGTGGCGGCGGCGGCGGTAAGCGGAACTTCGGCCCGAGGGGCTCGCCCGCT
CCCGCCTCTGTCTTGTCGGCCTCCACCTGCAGCCCCGCGGCCCCCGCGCCCCGCGGGACCCGGACGGCGACGACGGGGGAATGTGGCGCT
GGATCCGGCAGCAGCTGGGTTTTGACCCACCACATCAGAGTGACACAAGAACCATCTACGTAGCCAACAGGTTTCCTCAGAATGGCCTTT
ACACACCTCAGAAATTTATAGATAACAGGATCATTTCATCTAAGTACACTGTGTGGAATTTTGTTCCAAAAAATTTATTTGAACAGTTCA
GAAGAGTGGCAAACTTTTATTTTCTTATTATATTTTTGGTTCAGCTTATGATTGATACACCTACCAGTCCAGTTACCAGTGGACTTCCAT
TATTCTTTGTGATAACAGTAACTGCCATAAAGCAGGGATATGAAGATTGGTTACGGCATAACTCAGATAATGAAGTAAATGGAGCTCCTG
TTTATGTTGTTCGAAGTGGTGGCCTTGTAAAAACTAGATCAAAAAACATTCGGGTGGGTGATATTGTTCGAATAGCCAAAGATGAAATTT
TTCCTGCAGACTTGGTGCTTCTGTCCTCAGATCGACTGGATGGTTCCTGTCACGTTACAACTGCTAGTTTGGACGGAGAAACTAACCTGA
AGAAAAAGCCACCACGTGAGAATGGCCATAAGCAGATAAGTAGCAGTTCAACTGGATGTCTCTCTTCTCCAAATGCTACAGTACAAAGCC
CTAAGCATGAGTGGAAAATCGTTGCTTCAGAAAAGACTTCAAATAACACTTACTTGTGCCTGGCTGTGCTGGATGGTATATTCTGTGTCA
TTTTTCTTCATGGGAGAAACAGCCCACAGAGCTCACCAACAAGTACTCCAAAACTAAGTAAGAGTTTAAGCTTTGAGATGCAACAAGATG
AGCTAATCGAAAAGCCCATGTCTCCTATGCAGTACGCACGATCTGGTCTGGGAACAGCAGAGATGAATGGCAAACTCATAGCTGCAGGTG
GCTATAACAGAGAGGAATGTCTTCGAACAGTCGAATGCTATAATCCACATACAGATCACTGGTCCTTTCTTGCTCCCATGAGAACACCAA
GAGCCCGATTTCAAATGGCTGTACTCATGGGCCAGCTCTATGTGGTAGGTGGATCAAATGGCCACTCAGATGACCTGAGTTGTGGAGAGA
TGTATGATTCAAACATAGATGACTGGATTCCTGTTCCAGAATTGAGAACTAACCGTTGTAATGCAGGAGTGTGTGCTCTGAATGGAAAGT
TATACATCGTTGGTGGCTCTGATCCATATGGTCAAAAAGGACTGAAAAATTGTGATGTATTTGATCCTGTAACAAAGTTGTGGACAAGCT
GTGCCCCTCTTAACATTCGGAGACACCAGTCTGCAGTCTGTGAGCTTGGTGGTTATTTGTACATAATCGGAGGTGCAGAATCTTGGAATT
GTCTGAACACAGTAGAACGATACAATCCTGAAAATAATACCTGGACTTTAATTGCACCCATGAATGTGGCTAGGCGAGGAGCTGGAGTGG
CTGTTCTTAATGGAAAACTGTTTGTATGTGGTGGCTTTGATGGTTCTCATGCCATCAGTTGTGTGGAAATGTATGATCCAACTAGAAATG
AATGGAAGATGATGGGAAATATGACTTCACCAAGGAGCAATGCTGGGATTGCAACTGTAGGGAACACCATTTATGCAGTGGGAGGATTCG
ATGGCAATGAATTTCTGAATACGGTGGAAGTCTATAACCTTGAGTCAAATGAATGGAGCCCCTATACAAAGATTTTCCAGTTTTAACAAA
TTTAAGACCCTCTCAAACTAACAGGCTTAGTGATGTAATTATGGTTAGTAGAGGTACACTTGTGAATAAAGAGGGTGGGTGGGTATAGAT
GTTGCTAACAGCAACACAAAGCTTTTGCATATTGCATACTATTAAACATGCTGTACATACTTTTTGGGTTTATTTGGAAAGGAATGCAAA
GATGAAGGTCTGTTTTGTGTACTTTTAAGACTTTGGTTATTTTACTTTTTGGAAAAGAATAAACCAAGAATTGATTGGGCACATCATTTC
AAGAAGTCCCCTCTCCTCCACATTTGTTTTGCCAATTTGCACATTAAATGACTCTTCCCTCAAATGTGTACTATGGGGTAAAAGGGGTAG
GGTTTAAAGATGTAGACAGTTGGGTTTTTTAAGGGCCCTTTTTCAATAACTGGAACACTCTATAACAAAGGATACTTATTTAAATAGATG
ACATTGACTATTTTTGTTTTTATTAAAAGGAAGCTTACATGCCTACCAATATTTAATCTTTTATGATTGCCTTTTTATAACTTTTTATAT
TCTCAGCAGAGTGCTTTACCAATTGAAGTAAAATGTGGCAGGCTGGAGTTATTGAAGCAGAGTGGCAGTCTTCAGTTTGCAGAGTAGGGG
TCTGTCTTTTAAACTCTGAGTGCAAACTTCAGAGTTCTTGCCTTGGCTGCAGTTTTTTTCCTTCAAGAATGCAGTACTAACATTTATTTG
AGTGGAGTTACTGAACAGTAACATAGCTGTGATTTTTGGTATTTGAAACACTGGTTTTAAATATTTTGACTTGTTGAGGGTATGTTTTAT
ATAGCAAGACATTATATAGCAGTAAAAAATGGTGTTTTATCTTCTATATAATTCCTGTTTTTATTATTAACAAAACAGTCCTAAATAGCA
GCCCTCAATTGTGAAAAAATTTACTTTAAACTACATTAGGTTGTGAATGCAGGTTTTATCAGAACTATGTTTTTGTTCAGTTTATCTGTT
CATATGGATAAATATTGGTTGGGATGACTTGGTGTCTAATGTGTAGTGCTACACACCTAACTTATGGGGCCAAAATAGCATGTCCTAATG
CTTGCTGCTGATTTAAACACATTAAAGGTACTTTGCAGGAAATCCTTGCACCATGGGATTAATATCCAATTGCTGCTTGTACACTCATTC
ATTACTAAAAGTTTTGAGAAATTTTTTTTTCCAGTAATGAGCTTAAGAAATTTGTGGAAAATAACTCACCTGGCATCTTACATCTGAAAT
AAGGAATGATATAAGGTTTTTTTTTCTCACAGAAGATGAAGCACACAGGAACCTAATGGGCCAACTGGGATGAGGTGACTATTCTGAGAT
GACTATTCAGTGGCTAACTTGGGTTAGGAAGAAAATAATTAGGTATTTTCTCCAAATGTTCACTGGTACTCTGCCACTTTATTTCTCTCA
TCTGTTACACAAAGAACCACCAGGAAAGCAAATCAGTTTGGTTGGTAACTCTGTAATTCCTAACTATCACTGGTTTGGTTCTGGACTAAA
ACTACATTGACAGATTGAATTTGCCTAATATGATGACTGTTTTTAATATGGATCTGTATGTGTTCTATTCAGCACAAGGAAATAAAATTT
TAGTTGAGGATTCAGCACTAAAA

>7731_7731_1_ATP11B-IVNS1ABP_ATP11B_chr3_182554258_ENST00000323116_IVNS1ABP_chr1_185270695_ENST00000367498_length(amino acids)=589AA_BP=200
MQPRGPRAPRDPDGDDGGMWRWIRQQLGFDPPHQSDTRTIYVANRFPQNGLYTPQKFIDNRIISSKYTVWNFVPKNLFEQFRRVANFYFL
IIFLVQLMIDTPTSPVTSGLPLFFVITVTAIKQGYEDWLRHNSDNEVNGAPVYVVRSGGLVKTRSKNIRVGDIVRIAKDEIFPADLVLLS
SDRLDGSCHVTTASLDGETNLKKKPPRENGHKQISSSSTGCLSSPNATVQSPKHEWKIVASEKTSNNTYLCLAVLDGIFCVIFLHGRNSP
QSSPTSTPKLSKSLSFEMQQDELIEKPMSPMQYARSGLGTAEMNGKLIAAGGYNREECLRTVECYNPHTDHWSFLAPMRTPRARFQMAVL
MGQLYVVGGSNGHSDDLSCGEMYDSNIDDWIPVPELRTNRCNAGVCALNGKLYIVGGSDPYGQKGLKNCDVFDPVTKLWTSCAPLNIRRH
QSAVCELGGYLYIIGGAESWNCLNTVERYNPENNTWTLIAPMNVARRGAGVAVLNGKLFVCGGFDGSHAISCVEMYDPTRNEWKMMGNMT
SPRSNAGIATVGNTIYAVGGFDGNEFLNTVEVYNLESNEWSPYTKIFQF

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Fusion Gene PPI Analysis for ATP11B-IVNS1ABP


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ATP11B-IVNS1ABP


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ATP11B-IVNS1ABP


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneC0033578Prostatic Neoplasms1CTD_human
TgeneC0376358Malignant neoplasm of prostate1CTD_human