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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:FAM168A-TMEM135 (FusionGDB2 ID:HG23201TG65084)

Fusion Gene Summary for FAM168A-TMEM135

check button Fusion gene summary
Fusion gene informationFusion gene name: FAM168A-TMEM135
Fusion gene ID: hg23201tg65084
HgeneTgene
Gene symbol

FAM168A

TMEM135

Gene ID

23201

65084

Gene namefamily with sequence similarity 168 member Atransmembrane protein 135
SynonymsKIAA0280|TCRP1PMP52
Cytomap('FAM168A')('TMEM135')

11q13.4

11q14.2

Type of geneprotein-codingprotein-coding
Descriptionprotein FAM168Atongue cancer chemotherapy resistance-associated protein 1transmembrane protein 135peroxisomal membrane protein 52
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000064778, ENST00000356467, 
ENST00000450446, 
Fusion gene scores* DoF score27 X 14 X 13=491411 X 9 X 7=693
# samples 4112
** MAII scorelog2(41/4914*10)=-3.58320204285672
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(12/693*10)=-2.5298209465287
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: FAM168A [Title/Abstract] AND TMEM135 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointFAM168A(73308968)-TMEM135(86778736), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneFAM168A

GO:1905053

positive regulation of base-excision repair

25260657



check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUSCTCGA-94-7557-01AFAM168Achr11

73308968

-TMEM135chr11

86778736

+


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Fusion Gene ORF analysis for FAM168A-TMEM135

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000064778ENST00000340353FAM168Achr11

73308968

-TMEM135chr11

86778736

+
5UTR-3CDSENST00000356467ENST00000340353FAM168Achr11

73308968

-TMEM135chr11

86778736

+
5UTR-3CDSENST00000450446ENST00000340353FAM168Achr11

73308968

-TMEM135chr11

86778736

+
5UTR-5UTRENST00000064778ENST00000355734FAM168Achr11

73308968

-TMEM135chr11

86778736

+
5UTR-5UTRENST00000064778ENST00000535167FAM168Achr11

73308968

-TMEM135chr11

86778736

+
5UTR-5UTRENST00000356467ENST00000355734FAM168Achr11

73308968

-TMEM135chr11

86778736

+
5UTR-5UTRENST00000356467ENST00000535167FAM168Achr11

73308968

-TMEM135chr11

86778736

+
5UTR-5UTRENST00000450446ENST00000355734FAM168Achr11

73308968

-TMEM135chr11

86778736

+
5UTR-5UTRENST00000450446ENST00000535167FAM168Achr11

73308968

-TMEM135chr11

86778736

+
5UTR-intronENST00000064778ENST00000305494FAM168Achr11

73308968

-TMEM135chr11

86778736

+
5UTR-intronENST00000064778ENST00000532959FAM168Achr11

73308968

-TMEM135chr11

86778736

+
5UTR-intronENST00000356467ENST00000305494FAM168Achr11

73308968

-TMEM135chr11

86778736

+
5UTR-intronENST00000356467ENST00000532959FAM168Achr11

73308968

-TMEM135chr11

86778736

+
5UTR-intronENST00000450446ENST00000305494FAM168Achr11

73308968

-TMEM135chr11

86778736

+
5UTR-intronENST00000450446ENST00000532959FAM168Achr11

73308968

-TMEM135chr11

86778736

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for FAM168A-TMEM135


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
FAM168Achr1173308967-TMEM135chr1186778735+2.25E-060.99999774
FAM168Achr1173308967-TMEM135chr1186778735+2.25E-060.99999774


check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for FAM168A-TMEM135


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:73308968/:86778736)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for FAM168A-TMEM135


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for FAM168A-TMEM135


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for FAM168A-TMEM135


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for FAM168A-TMEM135


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneFAM168AC0024623Malignant neoplasm of stomach1CTD_human
HgeneFAM168AC0038356Stomach Neoplasms1CTD_human
HgeneFAM168AC0235874Disease Exacerbation1CTD_human
HgeneFAM168AC1708349Hereditary Diffuse Gastric Cancer1CTD_human
TgeneC0007131Non-Small Cell Lung Carcinoma1CTD_human
TgeneC0017636Glioblastoma1CTD_human
TgeneC0020796Profound Mental Retardation1CTD_human
TgeneC0025363Mental Retardation, Psychosocial1CTD_human
TgeneC0334588Giant Cell Glioblastoma1CTD_human
TgeneC0917816Mental deficiency1CTD_human
TgeneC1621958Glioblastoma Multiforme1CTD_human
TgeneC3714756Intellectual Disability1CTD_human