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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:FLT3LG-ALDH16A1 (FusionGDB2 ID:HG2323TG126133)

Fusion Gene Summary for FLT3LG-ALDH16A1

check button Fusion gene summary
Fusion gene informationFusion gene name: FLT3LG-ALDH16A1
Fusion gene ID: hg2323tg126133
HgeneTgene
Gene symbol

FLT3LG

ALDH16A1

Gene ID

2323

126133

Gene namefms related receptor tyrosine kinase 3 ligandaldehyde dehydrogenase 16 family member A1
SynonymsFL|FLG3L|FLT3L-
Cytomap('FLT3LG')('ALDH16A1')

19q13.33

19q13.33

Type of geneprotein-codingprotein-coding
Descriptionfms-related tyrosine kinase 3 ligandflt3 ligandfms related tyrosine kinase 3 ligandaldehyde dehydrogenase family 16 member A1
Modification date2020031320200313
UniProtAcc

P49771

Q8IZ83

Ensembl transtripts involved in fusion geneENST00000204637, ENST00000344019, 
ENST00000594009, ENST00000595510, 
ENST00000596435, ENST00000597551, 
ENST00000600429, 
Fusion gene scores* DoF score1 X 1 X 1=19 X 10 X 7=630
# samples 113
** MAII scorelog2(1/1*10)=3.32192809488736log2(13/630*10)=-2.27684020535882
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: FLT3LG [Title/Abstract] AND ALDH16A1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointFLT3LG(49979823)-ALDH16A1(49961743), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneFLT3LG

GO:0008284

positive regulation of cell proliferation

8180375

HgeneFLT3LG

GO:0035162

embryonic hemopoiesis

21149635


check buttonFusion gene breakpoints across FLT3LG (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across ALDH16A1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4HNSCTCGA-CN-4736-01AFLT3LGchr19

49979823

-ALDH16A1chr19

49961743

+
ChimerDB4HNSCTCGA-CN-4736FLT3LGchr19

49979823

+ALDH16A1chr19

49961743

+


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Fusion Gene ORF analysis for FLT3LG-ALDH16A1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000204637ENST00000598015FLT3LGchr19

49979823

+ALDH16A1chr19

49961743

+
5CDS-3UTRENST00000344019ENST00000598015FLT3LGchr19

49979823

+ALDH16A1chr19

49961743

+
5CDS-3UTRENST00000594009ENST00000598015FLT3LGchr19

49979823

+ALDH16A1chr19

49961743

+
5CDS-3UTRENST00000595510ENST00000598015FLT3LGchr19

49979823

+ALDH16A1chr19

49961743

+
5CDS-3UTRENST00000596435ENST00000598015FLT3LGchr19

49979823

+ALDH16A1chr19

49961743

+
5CDS-3UTRENST00000597551ENST00000598015FLT3LGchr19

49979823

+ALDH16A1chr19

49961743

+
5CDS-3UTRENST00000600429ENST00000598015FLT3LGchr19

49979823

+ALDH16A1chr19

49961743

+
5CDS-intronENST00000204637ENST00000433981FLT3LGchr19

49979823

+ALDH16A1chr19

49961743

+
5CDS-intronENST00000204637ENST00000455361FLT3LGchr19

49979823

+ALDH16A1chr19

49961743

+
5CDS-intronENST00000204637ENST00000540132FLT3LGchr19

49979823

+ALDH16A1chr19

49961743

+
5CDS-intronENST00000344019ENST00000433981FLT3LGchr19

49979823

+ALDH16A1chr19

49961743

+
5CDS-intronENST00000344019ENST00000455361FLT3LGchr19

49979823

+ALDH16A1chr19

49961743

+
5CDS-intronENST00000344019ENST00000540132FLT3LGchr19

49979823

+ALDH16A1chr19

49961743

+
5CDS-intronENST00000594009ENST00000433981FLT3LGchr19

49979823

+ALDH16A1chr19

49961743

+
5CDS-intronENST00000594009ENST00000455361FLT3LGchr19

49979823

+ALDH16A1chr19

49961743

+
5CDS-intronENST00000594009ENST00000540132FLT3LGchr19

49979823

+ALDH16A1chr19

49961743

+
5CDS-intronENST00000595510ENST00000433981FLT3LGchr19

49979823

+ALDH16A1chr19

49961743

+
5CDS-intronENST00000595510ENST00000455361FLT3LGchr19

49979823

+ALDH16A1chr19

49961743

+
5CDS-intronENST00000595510ENST00000540132FLT3LGchr19

49979823

+ALDH16A1chr19

49961743

+
5CDS-intronENST00000596435ENST00000433981FLT3LGchr19

49979823

+ALDH16A1chr19

49961743

+
5CDS-intronENST00000596435ENST00000455361FLT3LGchr19

49979823

+ALDH16A1chr19

49961743

+
5CDS-intronENST00000596435ENST00000540132FLT3LGchr19

49979823

+ALDH16A1chr19

49961743

+
5CDS-intronENST00000597551ENST00000433981FLT3LGchr19

49979823

+ALDH16A1chr19

49961743

+
5CDS-intronENST00000597551ENST00000455361FLT3LGchr19

49979823

+ALDH16A1chr19

49961743

+
5CDS-intronENST00000597551ENST00000540132FLT3LGchr19

49979823

+ALDH16A1chr19

49961743

+
5CDS-intronENST00000600429ENST00000433981FLT3LGchr19

49979823

+ALDH16A1chr19

49961743

+
5CDS-intronENST00000600429ENST00000455361FLT3LGchr19

49979823

+ALDH16A1chr19

49961743

+
5CDS-intronENST00000600429ENST00000540132FLT3LGchr19

49979823

+ALDH16A1chr19

49961743

+
In-frameENST00000204637ENST00000293350FLT3LGchr19

49979823

+ALDH16A1chr19

49961743

+
In-frameENST00000344019ENST00000293350FLT3LGchr19

49979823

+ALDH16A1chr19

49961743

+
In-frameENST00000594009ENST00000293350FLT3LGchr19

49979823

+ALDH16A1chr19

49961743

+
In-frameENST00000595510ENST00000293350FLT3LGchr19

49979823

+ALDH16A1chr19

49961743

+
In-frameENST00000596435ENST00000293350FLT3LGchr19

49979823

+ALDH16A1chr19

49961743

+
In-frameENST00000597551ENST00000293350FLT3LGchr19

49979823

+ALDH16A1chr19

49961743

+
In-frameENST00000600429ENST00000293350FLT3LGchr19

49979823

+ALDH16A1chr19

49961743

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for FLT3LG-ALDH16A1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
FLT3LGchr1949979823+ALDH16A1chr1949961742+3.85E-081
FLT3LGchr1949979823+ALDH16A1chr1949961742+3.85E-081

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for FLT3LG-ALDH16A1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:49979823/chr19:49961743)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FLT3LG

P49771

ALDH16A1

Q8IZ83

FUNCTION: Stimulates the proliferation of early hematopoietic cells by activating FLT3. Synergizes well with a number of other colony stimulating factors and interleukins.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneFLT3LGchr19:49979823chr19:49961743ENST00000344019+57206_235114179.0Topological domainCytoplasmic
HgeneFLT3LGchr19:49979823chr19:49961743ENST00000344019+5727_184114179.0Topological domainExtracellular
HgeneFLT3LGchr19:49979823chr19:49961743ENST00000594009+48206_235114288.0Topological domainCytoplasmic
HgeneFLT3LGchr19:49979823chr19:49961743ENST00000594009+4827_184114288.0Topological domainExtracellular
HgeneFLT3LGchr19:49979823chr19:49961743ENST00000597551+59206_235114265.6666666666667Topological domainCytoplasmic
HgeneFLT3LGchr19:49979823chr19:49961743ENST00000597551+5927_184114265.6666666666667Topological domainExtracellular
HgeneFLT3LGchr19:49979823chr19:49961743ENST00000600429+59206_235114288.6666666666667Topological domainCytoplasmic
HgeneFLT3LGchr19:49979823chr19:49961743ENST00000600429+5927_184114288.6666666666667Topological domainExtracellular
HgeneFLT3LGchr19:49979823chr19:49961743ENST00000344019+57185_205114179.0TransmembraneHelical
HgeneFLT3LGchr19:49979823chr19:49961743ENST00000594009+48185_205114288.0TransmembraneHelical
HgeneFLT3LGchr19:49979823chr19:49961743ENST00000597551+59185_205114265.6666666666667TransmembraneHelical
HgeneFLT3LGchr19:49979823chr19:49961743ENST00000600429+59185_205114288.6666666666667TransmembraneHelical


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Fusion Gene Sequence for FLT3LG-ALDH16A1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for FLT3LG-ALDH16A1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for FLT3LG-ALDH16A1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for FLT3LG-ALDH16A1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneC0018099Gout1CTD_human
TgeneC0268117Gout, HPRT-Related1CTD_human
TgeneC0740394Hyperuricemia1CTD_human