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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ANKRD28-TM9SF4 (FusionGDB2 ID:HG23243TG9777)

Fusion Gene Summary for ANKRD28-TM9SF4

check button Fusion gene summary
Fusion gene informationFusion gene name: ANKRD28-TM9SF4
Fusion gene ID: hg23243tg9777
HgeneTgene
Gene symbol

ANKRD28

TM9SF4

Gene ID

23243

9777

Gene nameankyrin repeat domain 28transmembrane 9 superfamily member 4
SynonymsCFAP79|FAP79|PITK|PPP1R65dJ836N17.2
Cytomap('ANKRD28')('TM9SF4')

3p25.1

20q11.21

Type of geneprotein-codingprotein-coding
Descriptionserine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit APP6-ARS-Aankyrin repeat domain-containing protein 28phosphatase interactor targeting K proteinphosphatase interactor targeting protein hnRNP Kprotein phosphatase 1, regulatory transmembrane 9 superfamily member 4dinucleotide oxidase disulfide thiol exchanger 3 superfamily member 4transmembrane 9 superfamily protein member 4tumor cannibalism associated protein 1
Modification date2020032020200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000383777, ENST00000399451, 
ENST00000497037, 
Fusion gene scores* DoF score18 X 13 X 13=30429 X 9 X 7=567
# samples 2114
** MAII scorelog2(21/3042*10)=-3.85655892005837
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(14/567*10)=-2.01792190799726
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ANKRD28 [Title/Abstract] AND TM9SF4 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointANKRD28(15836730)-TM9SF4(30720816), # samples:3
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneTM9SF4

GO:0001666

response to hypoxia

25961573


check buttonFusion gene breakpoints across ANKRD28 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across TM9SF4 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SKCMTCGA-FS-A1ZF-06AANKRD28chr3

15836730

-TM9SF4chr20

30720816

+


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Fusion Gene ORF analysis for ANKRD28-TM9SF4

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000383777ENST00000217315ANKRD28chr3

15836730

-TM9SF4chr20

30720816

+
5CDS-5UTRENST00000399451ENST00000217315ANKRD28chr3

15836730

-TM9SF4chr20

30720816

+
5UTR-3CDSENST00000497037ENST00000398022ANKRD28chr3

15836730

-TM9SF4chr20

30720816

+
5UTR-5UTRENST00000497037ENST00000217315ANKRD28chr3

15836730

-TM9SF4chr20

30720816

+
In-frameENST00000383777ENST00000398022ANKRD28chr3

15836730

-TM9SF4chr20

30720816

+
In-frameENST00000399451ENST00000398022ANKRD28chr3

15836730

-TM9SF4chr20

30720816

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000383777ANKRD28chr315836730-ENST00000398022TM9SF4chr2030720816+393821002123707
ENST00000399451ANKRD28chr315836730-ENST00000398022TM9SF4chr2030720816+42074793682392674

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000383777ENST00000398022ANKRD28chr315836730-TM9SF4chr2030720816+0.0016857110.99831426
ENST00000399451ENST00000398022ANKRD28chr315836730-TM9SF4chr2030720816+0.0023244650.9976756

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Fusion Genomic Features for ANKRD28-TM9SF4


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
ANKRD28chr315836729-TM9SF4chr2030720815+7.03E-080.9999999
ANKRD28chr315836729-TM9SF4chr2030720815+7.03E-080.9999999

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for ANKRD28-TM9SF4


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:15836730/chr20:30720816)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneANKRD28chr3:15836730chr20:30720816ENST00000383777-22840_69701087.0RepeatNote=ANK 1
TgeneTM9SF4chr3:15836730chr20:30720816ENST0000021731501824_2810626.0Topological domainExtracellular
TgeneTM9SF4chr3:15836730chr20:30720816ENST00000217315018303_3460626.0Topological domainCytoplasmic
TgeneTM9SF4chr3:15836730chr20:30720816ENST00000217315018368_3760626.0Topological domainExtracellular
TgeneTM9SF4chr3:15836730chr20:30720816ENST00000217315018398_4160626.0Topological domainCytoplasmic
TgeneTM9SF4chr3:15836730chr20:30720816ENST00000217315018438_4490626.0Topological domainExtracellular
TgeneTM9SF4chr3:15836730chr20:30720816ENST00000217315018471_5010626.0Topological domainCytoplasmic
TgeneTM9SF4chr3:15836730chr20:30720816ENST00000217315018523_5350626.0Topological domainExtracellular
TgeneTM9SF4chr3:15836730chr20:30720816ENST00000217315018557_5700626.0Topological domainCytoplasmic
TgeneTM9SF4chr3:15836730chr20:30720816ENST00000217315018592_5980626.0Topological domainExtracellular
TgeneTM9SF4chr3:15836730chr20:30720816ENST00000217315018620_6420626.0Topological domainCytoplasmic
TgeneTM9SF4chr3:15836730chr20:30720816ENST0000039802201824_2815643.0Topological domainExtracellular
TgeneTM9SF4chr3:15836730chr20:30720816ENST00000398022018303_3465643.0Topological domainCytoplasmic
TgeneTM9SF4chr3:15836730chr20:30720816ENST00000398022018368_3765643.0Topological domainExtracellular
TgeneTM9SF4chr3:15836730chr20:30720816ENST00000398022018398_4165643.0Topological domainCytoplasmic
TgeneTM9SF4chr3:15836730chr20:30720816ENST00000398022018438_4495643.0Topological domainExtracellular
TgeneTM9SF4chr3:15836730chr20:30720816ENST00000398022018471_5015643.0Topological domainCytoplasmic
TgeneTM9SF4chr3:15836730chr20:30720816ENST00000398022018523_5355643.0Topological domainExtracellular
TgeneTM9SF4chr3:15836730chr20:30720816ENST00000398022018557_5705643.0Topological domainCytoplasmic
TgeneTM9SF4chr3:15836730chr20:30720816ENST00000398022018592_5985643.0Topological domainExtracellular
TgeneTM9SF4chr3:15836730chr20:30720816ENST00000398022018620_6425643.0Topological domainCytoplasmic
TgeneTM9SF4chr3:15836730chr20:30720816ENST00000217315018282_3020626.0TransmembraneHelical
TgeneTM9SF4chr3:15836730chr20:30720816ENST00000217315018347_3670626.0TransmembraneHelical
TgeneTM9SF4chr3:15836730chr20:30720816ENST00000217315018377_3970626.0TransmembraneHelical
TgeneTM9SF4chr3:15836730chr20:30720816ENST00000217315018417_4370626.0TransmembraneHelical
TgeneTM9SF4chr3:15836730chr20:30720816ENST00000217315018450_4700626.0TransmembraneHelical
TgeneTM9SF4chr3:15836730chr20:30720816ENST00000217315018502_5220626.0TransmembraneHelical
TgeneTM9SF4chr3:15836730chr20:30720816ENST00000217315018536_5560626.0TransmembraneHelical
TgeneTM9SF4chr3:15836730chr20:30720816ENST00000217315018571_5910626.0TransmembraneHelical
TgeneTM9SF4chr3:15836730chr20:30720816ENST00000217315018599_6190626.0TransmembraneHelical
TgeneTM9SF4chr3:15836730chr20:30720816ENST00000398022018282_3025643.0TransmembraneHelical
TgeneTM9SF4chr3:15836730chr20:30720816ENST00000398022018347_3675643.0TransmembraneHelical
TgeneTM9SF4chr3:15836730chr20:30720816ENST00000398022018377_3975643.0TransmembraneHelical
TgeneTM9SF4chr3:15836730chr20:30720816ENST00000398022018417_4375643.0TransmembraneHelical
TgeneTM9SF4chr3:15836730chr20:30720816ENST00000398022018450_4705643.0TransmembraneHelical
TgeneTM9SF4chr3:15836730chr20:30720816ENST00000398022018502_5225643.0TransmembraneHelical
TgeneTM9SF4chr3:15836730chr20:30720816ENST00000398022018536_5565643.0TransmembraneHelical
TgeneTM9SF4chr3:15836730chr20:30720816ENST00000398022018571_5915643.0TransmembraneHelical
TgeneTM9SF4chr3:15836730chr20:30720816ENST00000398022018599_6195643.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneANKRD28chr3:15836730chr20:30720816ENST00000383777-228106_135701087.0RepeatNote=ANK 3
HgeneANKRD28chr3:15836730chr20:30720816ENST00000383777-228139_168701087.0RepeatNote=ANK 4
HgeneANKRD28chr3:15836730chr20:30720816ENST00000383777-228172_201701087.0RepeatNote=ANK 5
HgeneANKRD28chr3:15836730chr20:30720816ENST00000383777-228205_234701087.0RepeatNote=ANK 6
HgeneANKRD28chr3:15836730chr20:30720816ENST00000383777-228238_267701087.0RepeatNote=ANK 7
HgeneANKRD28chr3:15836730chr20:30720816ENST00000383777-228271_301701087.0RepeatNote=ANK 8
HgeneANKRD28chr3:15836730chr20:30720816ENST00000383777-228305_334701087.0RepeatNote=ANK 9
HgeneANKRD28chr3:15836730chr20:30720816ENST00000383777-228338_367701087.0RepeatNote=ANK 10
HgeneANKRD28chr3:15836730chr20:30720816ENST00000383777-228371_400701087.0RepeatNote=ANK 11
HgeneANKRD28chr3:15836730chr20:30720816ENST00000383777-228404_433701087.0RepeatNote=ANK 12
HgeneANKRD28chr3:15836730chr20:30720816ENST00000383777-228437_466701087.0RepeatNote=ANK 13
HgeneANKRD28chr3:15836730chr20:30720816ENST00000383777-228470_500701087.0RepeatNote=ANK 14
HgeneANKRD28chr3:15836730chr20:30720816ENST00000383777-228504_534701087.0RepeatNote=ANK 15
HgeneANKRD28chr3:15836730chr20:30720816ENST00000383777-228549_578701087.0RepeatNote=ANK 16
HgeneANKRD28chr3:15836730chr20:30720816ENST00000383777-228582_611701087.0RepeatNote=ANK 17
HgeneANKRD28chr3:15836730chr20:30720816ENST00000383777-228616_645701087.0RepeatNote=ANK 18
HgeneANKRD28chr3:15836730chr20:30720816ENST00000383777-228652_681701087.0RepeatNote=ANK 19
HgeneANKRD28chr3:15836730chr20:30720816ENST00000383777-228685_714701087.0RepeatNote=ANK 20
HgeneANKRD28chr3:15836730chr20:30720816ENST00000383777-228718_747701087.0RepeatNote=ANK 21
HgeneANKRD28chr3:15836730chr20:30720816ENST00000383777-22873_102701087.0RepeatNote=ANK 2
HgeneANKRD28chr3:15836730chr20:30720816ENST00000383777-228755_784701087.0RepeatNote=ANK 22
HgeneANKRD28chr3:15836730chr20:30720816ENST00000383777-228787_817701087.0RepeatNote=ANK 23
HgeneANKRD28chr3:15836730chr20:30720816ENST00000383777-228822_851701087.0RepeatNote=ANK 24
HgeneANKRD28chr3:15836730chr20:30720816ENST00000383777-228855_885701087.0RepeatNote=ANK 25
HgeneANKRD28chr3:15836730chr20:30720816ENST00000383777-228889_918701087.0RepeatNote=ANK 26
HgeneANKRD28chr3:15836730chr20:30720816ENST00000383777-228925_954701087.0RepeatNote=ANK 27
HgeneANKRD28chr3:15836730chr20:30720816ENST00000399451-228106_135371054.0RepeatNote=ANK 3
HgeneANKRD28chr3:15836730chr20:30720816ENST00000399451-228139_168371054.0RepeatNote=ANK 4
HgeneANKRD28chr3:15836730chr20:30720816ENST00000399451-228172_201371054.0RepeatNote=ANK 5
HgeneANKRD28chr3:15836730chr20:30720816ENST00000399451-228205_234371054.0RepeatNote=ANK 6
HgeneANKRD28chr3:15836730chr20:30720816ENST00000399451-228238_267371054.0RepeatNote=ANK 7
HgeneANKRD28chr3:15836730chr20:30720816ENST00000399451-228271_301371054.0RepeatNote=ANK 8
HgeneANKRD28chr3:15836730chr20:30720816ENST00000399451-228305_334371054.0RepeatNote=ANK 9
HgeneANKRD28chr3:15836730chr20:30720816ENST00000399451-228338_367371054.0RepeatNote=ANK 10
HgeneANKRD28chr3:15836730chr20:30720816ENST00000399451-228371_400371054.0RepeatNote=ANK 11
HgeneANKRD28chr3:15836730chr20:30720816ENST00000399451-228404_433371054.0RepeatNote=ANK 12
HgeneANKRD28chr3:15836730chr20:30720816ENST00000399451-22840_69371054.0RepeatNote=ANK 1
HgeneANKRD28chr3:15836730chr20:30720816ENST00000399451-228437_466371054.0RepeatNote=ANK 13
HgeneANKRD28chr3:15836730chr20:30720816ENST00000399451-228470_500371054.0RepeatNote=ANK 14
HgeneANKRD28chr3:15836730chr20:30720816ENST00000399451-228504_534371054.0RepeatNote=ANK 15
HgeneANKRD28chr3:15836730chr20:30720816ENST00000399451-228549_578371054.0RepeatNote=ANK 16
HgeneANKRD28chr3:15836730chr20:30720816ENST00000399451-228582_611371054.0RepeatNote=ANK 17
HgeneANKRD28chr3:15836730chr20:30720816ENST00000399451-228616_645371054.0RepeatNote=ANK 18
HgeneANKRD28chr3:15836730chr20:30720816ENST00000399451-228652_681371054.0RepeatNote=ANK 19
HgeneANKRD28chr3:15836730chr20:30720816ENST00000399451-228685_714371054.0RepeatNote=ANK 20
HgeneANKRD28chr3:15836730chr20:30720816ENST00000399451-228718_747371054.0RepeatNote=ANK 21
HgeneANKRD28chr3:15836730chr20:30720816ENST00000399451-22873_102371054.0RepeatNote=ANK 2
HgeneANKRD28chr3:15836730chr20:30720816ENST00000399451-228755_784371054.0RepeatNote=ANK 22
HgeneANKRD28chr3:15836730chr20:30720816ENST00000399451-228787_817371054.0RepeatNote=ANK 23
HgeneANKRD28chr3:15836730chr20:30720816ENST00000399451-228822_851371054.0RepeatNote=ANK 24
HgeneANKRD28chr3:15836730chr20:30720816ENST00000399451-228855_885371054.0RepeatNote=ANK 25
HgeneANKRD28chr3:15836730chr20:30720816ENST00000399451-228889_918371054.0RepeatNote=ANK 26
HgeneANKRD28chr3:15836730chr20:30720816ENST00000399451-228925_954371054.0RepeatNote=ANK 27


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Fusion Gene Sequence for ANKRD28-TM9SF4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>4675_4675_1_ANKRD28-TM9SF4_ANKRD28_chr3_15836730_ENST00000383777_TM9SF4_chr20_30720816_ENST00000398022_length(transcript)=3938nt_BP=210nt
ATGAGTCGAGTGTGTATTGTTGTTTTGGAGGAGGTAGAAGATGAATCTCCTGCATTCATTTCTAAATTGCCACAGGAAAATAAATCCCTA
CATTCTCCACCTTCTGGAAATGTATTGGTAAGATATCCATCACTGGTGCAAGCTATATTTAACGGAGATCCTGATGAAGTTCGAGCACTA
ATATTTAAGAAAGAAGATGTTAACTTTCAGGATTGGTTGCCGTGGTCTTTACTGCTTTTCTCCCTGATGTGTGAAACAAGCGCCTTCTAT
GTGCCTGGGGTCGCGCCTATCAACTTCCACCAGAACGATCCCGTAGAAATCAAGGCTGTGAAGCTCACCAGCTCTCGAACCCAGCTACCT
TATGAATACTATTCACTGCCCTTCTGCCAGCCCAGCAAGATAACCTACAAGGCAGAGAATCTGGGAGAGGTGCTGAGAGGGGACCGGATT
GTCAACACCCCTTTCCAGGTTCTCATGAACAGCGAGAAGAAGTGTGAAGTTCTGTGCAGCCAGTCCAACAAGCCAGTGACCCTGACAGTG
GAGCAGAGCCGACTCGTGGCCGAGCGGATCACAGAAGACTACTACGTCCACCTCATTGCTGACAACCTGCCTGTGGCCACCCGGCTGGAG
CTCTACTCCAACCGAGACAGCGATGACAAGAAGAAGGAAAAAGATGTGCAGTTTGAACACGGCTACCGGCTCGGCTTCACAGATGTCAAC
AAGATCTACCTGCACAACCACCTCTCATTCATCCTTTACTATCATCGGGAGGACATGGAAGAGGACCAGGAGCACACGTACCGTGTCGTC
CGCTTCGAGGTGATTCCCCAGAGCATCAGGCTGGAGGACCTCAAAGCAGATGAGAAGAGTTCGTGCACTCTGCCTGAGGGTACCAACTCC
TCGCCCCAAGAAATTGACCCCACCAAGGAGAATCAGCTGTACTTCACCTACTCTGTCCACTGGGAGGAAAGTGATATCAAATGGGCCTCT
CGCTGGGACACTTACCTGACCATGAGTGACGTCCAGATCCACTGGTTTTCTATCATTAACTCCGTTGTTGTGGTCTTCTTCCTGTCAGGT
ATCCTGAGCATGATTATCATTCGGACCCTCCGGAAGGACATTGCCAACTACAACAAGGAGGATGACATTGAAGACACCATGGAGGAGTCT
GGGTGGAAGTTGGTGCACGGCGACGTCTTCAGGCCCCCCCAGTACCCCATGATCCTCAGCTCCCTGCTGGGCTCAGGCATTCAGCTGTTC
TGTATGATCCTCATCGTCATCTTTGTAGCCATGCTTGGGATGCTGTCGCCCTCCAGCCGGGGAGCTCTCATGACCACAGCCTGCTTCCTC
TTCATGTTCATGGGGGTGTTTGGCGGATTTTCTGCTGGCCGTCTGTACCGCACTTTAAAAGGCCATCGGTGGAAGAAAGGAGCCTTCTGT
ACGGCAACTCTGTACCCTGGTGTGGTTTTTGGCATCTGCTTCGTATTGAATTGCTTCATTTGGGGAAAGCACTCATCAGGAGCGGTGCCC
TTTCCCACCATGGTGGCTCTGCTGTGCATGTGGTTCGGGATCTCCCTGCCCCTCGTCTACTTGGGCTACTACTTCGGCTTCCGAAAGCAG
CCATATGACAACCCTGTGCGCACCAACCAGATTCCCCGGCAGATCCCCGAGCAGCGGTGGTACATGAACCGATTTGTGGGCATCCTCATG
GCTGGGATCTTGCCCTTCGGCGCCATGTTCATCGAGCTCTTCTTCATCTTCAGTGCTATCTGGGAGAATCAGTTCTATTACCTCTTTGGC
TTCCTGTTCCTTGTTTTCATCATCCTGGTGGTATCCTGTTCACAAATCAGCATCGTCATGGTGTACTTCCAGCTGTGTGCAGAGGATTAC
CGCTGGTGGTGGAGAAATTTCCTAGTCTCCGGGGGCTCTGCATTCTACGTCCTGGTTTATGCCATCTTTTATTTCGTTAACAAGCTGGAC
ATCGTGGAGTTCATCCCCTCTCTCCTCTACTTTGGCTACACGGCCCTCATGGTCTTGTCCTTCTGGCTGCTAACGGGTACCATCGGCTTC
TATGCAGCCTACATGTTTGTTCGCAAGATCTATGCTGCTGTGAAGATAGACTGATTGGAGTGGACCACGGCCAAGCTTGCTCCGTCCTCG
GACAGGAAGCCACCCTGCGTGGGGGACTGCAGGCACGCAAAATAAAATAACTCCTGCTCGTTTGGAATGTAACTCCTGGCACAGTGTTCC
TGGATCCTGGGGCTGCGTGGGGGGCGGGAGGGCCTGTAGATAATCTTGCGTTTTTCGTCATCTTATTCCAGTTCTGTGGGGGATGAGTTT
TTTTGTGGGTTGCTTTTTCTTCAGTGCTAAGAAAGTTCCCTCCAACAGGAACTCTCTGACCTGTTTATTCAGGTGTATTTCTGGTTTGGA
TTTTTTTTTCCTTCTTTGTTTTAACAAATGGATCCAGGATGGATAAATCCACCGAGATAAGGGTTTTGGTCACTGTCTCCACCTCAGTTC
CTCAGGGCTGTTGGCCACCCTATGACTAACTGGAAGAGGACACGCCAGAGCTTCAGTGAGGTTTCCGAGCCTCTCCCTGCCCATCCTCAC
CACTGAGGCCACGACAAAGCACAGCTCCAGCTCGGACAGCACCCTCAGTGCCAGCCAGCCTCTGCCAGACCTCTCTTTCCCTCTTCTCCC
CAGCCTCCTCCAGGGCTGCCCAAGGCAGGGTTTCCAGCCAGGCCTCGGGGTCATCTTTTCACCAGGAGCAAACCCAAGTCTTAGTTGCTA
CAAGAAAATCCCCTGGAAGTACTGGGGGCCAGGTTCCCCAGACAGCAGGAATTGCCCCTGTTCAGAGCAGCCGGAGTTTGCTGGACCACA
AGGAAGAAGAGAAGAGACTTGCAGTGAACTGTTTTTGTGCCAAGAAACCCTGGACCTGGGGCCAAGTATTTCCCAAGCCAAGCATCCACT
TGTCTGTGTCTGGGAAGGGATGGCCAAGGCCGCTAGGGTCCTTACCCCTCAGGATCACTCCCCAGCCCTTTCCTCAGGAGGTACCGCTCT
CCAAGGTGTGCTAGCAGTGGGCCCTGCCCAACTTCAGGCAGAACAGGGAGGCCCAGAGATTACAGATCCCCTCCTGTAAGTGGCCAGGCA
TTCTCTCCCTGCCCTCTCTGGCCTCTGGGGTCATACTCACTTCTTTAGCCAGCCCCATCCCCTCCACCCCACACCTGAGTTCTTGCCTCC
TCCTTTTGGGGACACCCAAAACACTGCTTGTGAGAAGGAAGATGGAAGGTAAGTTCTGTCGTTCTTTCCCCAATCCCCAGGAATGGACAA
GAAGCCAACTTAGAAAGAAGGGTCTCACGTGGCTGGCCTGGCTCCTCCGTAGACCCCTGTTCTTTTCAACCTCTGCCCACCCGTGCATGT
CATCACAAACATTTGCTCTTAAGTTACAAGAGACCACATCCACCCAGGGATTAGGGTTCAAGTAGCAGCTGCTAACCCTTGCACCAGCCC
TTGTGGGACTCCCAACACAAGACAAAGCTCAGGATGCTGGTGATGCTAGGAAGATGTCCCTCCCCTCACTGCCCCACATTCTCCCAGTGG
CTCTACCAGCCTCACCCATCAAACCAGTGAATTTCTCAATCTTGCCTCACAGTGACTGCAGCGCCAAGCGGCATCCACCAAGCATCAAGT
TGGAGAAAAGGGAACCCAAGCAGTAGAGAGCGATATTGGAGTCTTTTGTTCATTCAAATCTTGGATTTTTTTTTTTCCCTAAGAGATTCT
CTTTTTAGGGGGAATGGGAAACGGACACCTCATAAAGGGTTCAAAGATCATCAATTTTTCTGACTTTTTAAATCATTATCATTATTATTT

>4675_4675_1_ANKRD28-TM9SF4_ANKRD28_chr3_15836730_ENST00000383777_TM9SF4_chr20_30720816_ENST00000398022_length(amino acids)=707AA_BP=69
MSRVCIVVLEEVEDESPAFISKLPQENKSLHSPPSGNVLVRYPSLVQAIFNGDPDEVRALIFKKEDVNFQDWLPWSLLLFSLMCETSAFY
VPGVAPINFHQNDPVEIKAVKLTSSRTQLPYEYYSLPFCQPSKITYKAENLGEVLRGDRIVNTPFQVLMNSEKKCEVLCSQSNKPVTLTV
EQSRLVAERITEDYYVHLIADNLPVATRLELYSNRDSDDKKKEKDVQFEHGYRLGFTDVNKIYLHNHLSFILYYHREDMEEDQEHTYRVV
RFEVIPQSIRLEDLKADEKSSCTLPEGTNSSPQEIDPTKENQLYFTYSVHWEESDIKWASRWDTYLTMSDVQIHWFSIINSVVVVFFLSG
ILSMIIIRTLRKDIANYNKEDDIEDTMEESGWKLVHGDVFRPPQYPMILSSLLGSGIQLFCMILIVIFVAMLGMLSPSSRGALMTTACFL
FMFMGVFGGFSAGRLYRTLKGHRWKKGAFCTATLYPGVVFGICFVLNCFIWGKHSSGAVPFPTMVALLCMWFGISLPLVYLGYYFGFRKQ
PYDNPVRTNQIPRQIPEQRWYMNRFVGILMAGILPFGAMFIELFFIFSAIWENQFYYLFGFLFLVFIILVVSCSQISIVMVYFQLCAEDY

--------------------------------------------------------------
>4675_4675_2_ANKRD28-TM9SF4_ANKRD28_chr3_15836730_ENST00000399451_TM9SF4_chr20_30720816_ENST00000398022_length(transcript)=4207nt_BP=479nt
GCGGCCGCGGGGGCTGCCAGGGTATTTCGGGAAGGGGGCGTGAGGAGGCGGCGGCGGCAGCGGCGGGTAGGGCAGGCAGCAGAGGGAAGG
AGAAAGAAAGGAAGGAAGAGGGCGGGGAGTCCTCAGAGGAGGAGGCGGGACCGGCCGGGCACCTCACCTCTCGGCGGCGGCGGCGGCGGC
GGCGGCGGCGGGCGGCCGGGGAGGCGGCGCCGCCCCCTGCCCGCAGGTCTTCTCAGCGCAGTCGGCCGCGGACCCGCTGGTCCCGGGCAG
CGGCCAAGGCTACTGGGGCGGGAGCAGTGGGCCGGTCGGCGGCGGCAGCGGCAGCGGCGGAGGAGGAGGAGGCTGGAGTGGGCGCGGAGG
CGACCGCCATGGCGTTCCTCAAACTCCGTGACCAGCCATCACTGGTGCAAGCTATATTTAACGGAGATCCTGATGAAGTTCGAGCACTAA
TATTTAAGAAAGAAGATGTTAACTTTCAGGATTGGTTGCCGTGGTCTTTACTGCTTTTCTCCCTGATGTGTGAAACAAGCGCCTTCTATG
TGCCTGGGGTCGCGCCTATCAACTTCCACCAGAACGATCCCGTAGAAATCAAGGCTGTGAAGCTCACCAGCTCTCGAACCCAGCTACCTT
ATGAATACTATTCACTGCCCTTCTGCCAGCCCAGCAAGATAACCTACAAGGCAGAGAATCTGGGAGAGGTGCTGAGAGGGGACCGGATTG
TCAACACCCCTTTCCAGGTTCTCATGAACAGCGAGAAGAAGTGTGAAGTTCTGTGCAGCCAGTCCAACAAGCCAGTGACCCTGACAGTGG
AGCAGAGCCGACTCGTGGCCGAGCGGATCACAGAAGACTACTACGTCCACCTCATTGCTGACAACCTGCCTGTGGCCACCCGGCTGGAGC
TCTACTCCAACCGAGACAGCGATGACAAGAAGAAGGAAAAAGATGTGCAGTTTGAACACGGCTACCGGCTCGGCTTCACAGATGTCAACA
AGATCTACCTGCACAACCACCTCTCATTCATCCTTTACTATCATCGGGAGGACATGGAAGAGGACCAGGAGCACACGTACCGTGTCGTCC
GCTTCGAGGTGATTCCCCAGAGCATCAGGCTGGAGGACCTCAAAGCAGATGAGAAGAGTTCGTGCACTCTGCCTGAGGGTACCAACTCCT
CGCCCCAAGAAATTGACCCCACCAAGGAGAATCAGCTGTACTTCACCTACTCTGTCCACTGGGAGGAAAGTGATATCAAATGGGCCTCTC
GCTGGGACACTTACCTGACCATGAGTGACGTCCAGATCCACTGGTTTTCTATCATTAACTCCGTTGTTGTGGTCTTCTTCCTGTCAGGTA
TCCTGAGCATGATTATCATTCGGACCCTCCGGAAGGACATTGCCAACTACAACAAGGAGGATGACATTGAAGACACCATGGAGGAGTCTG
GGTGGAAGTTGGTGCACGGCGACGTCTTCAGGCCCCCCCAGTACCCCATGATCCTCAGCTCCCTGCTGGGCTCAGGCATTCAGCTGTTCT
GTATGATCCTCATCGTCATCTTTGTAGCCATGCTTGGGATGCTGTCGCCCTCCAGCCGGGGAGCTCTCATGACCACAGCCTGCTTCCTCT
TCATGTTCATGGGGGTGTTTGGCGGATTTTCTGCTGGCCGTCTGTACCGCACTTTAAAAGGCCATCGGTGGAAGAAAGGAGCCTTCTGTA
CGGCAACTCTGTACCCTGGTGTGGTTTTTGGCATCTGCTTCGTATTGAATTGCTTCATTTGGGGAAAGCACTCATCAGGAGCGGTGCCCT
TTCCCACCATGGTGGCTCTGCTGTGCATGTGGTTCGGGATCTCCCTGCCCCTCGTCTACTTGGGCTACTACTTCGGCTTCCGAAAGCAGC
CATATGACAACCCTGTGCGCACCAACCAGATTCCCCGGCAGATCCCCGAGCAGCGGTGGTACATGAACCGATTTGTGGGCATCCTCATGG
CTGGGATCTTGCCCTTCGGCGCCATGTTCATCGAGCTCTTCTTCATCTTCAGTGCTATCTGGGAGAATCAGTTCTATTACCTCTTTGGCT
TCCTGTTCCTTGTTTTCATCATCCTGGTGGTATCCTGTTCACAAATCAGCATCGTCATGGTGTACTTCCAGCTGTGTGCAGAGGATTACC
GCTGGTGGTGGAGAAATTTCCTAGTCTCCGGGGGCTCTGCATTCTACGTCCTGGTTTATGCCATCTTTTATTTCGTTAACAAGCTGGACA
TCGTGGAGTTCATCCCCTCTCTCCTCTACTTTGGCTACACGGCCCTCATGGTCTTGTCCTTCTGGCTGCTAACGGGTACCATCGGCTTCT
ATGCAGCCTACATGTTTGTTCGCAAGATCTATGCTGCTGTGAAGATAGACTGATTGGAGTGGACCACGGCCAAGCTTGCTCCGTCCTCGG
ACAGGAAGCCACCCTGCGTGGGGGACTGCAGGCACGCAAAATAAAATAACTCCTGCTCGTTTGGAATGTAACTCCTGGCACAGTGTTCCT
GGATCCTGGGGCTGCGTGGGGGGCGGGAGGGCCTGTAGATAATCTTGCGTTTTTCGTCATCTTATTCCAGTTCTGTGGGGGATGAGTTTT
TTTGTGGGTTGCTTTTTCTTCAGTGCTAAGAAAGTTCCCTCCAACAGGAACTCTCTGACCTGTTTATTCAGGTGTATTTCTGGTTTGGAT
TTTTTTTTCCTTCTTTGTTTTAACAAATGGATCCAGGATGGATAAATCCACCGAGATAAGGGTTTTGGTCACTGTCTCCACCTCAGTTCC
TCAGGGCTGTTGGCCACCCTATGACTAACTGGAAGAGGACACGCCAGAGCTTCAGTGAGGTTTCCGAGCCTCTCCCTGCCCATCCTCACC
ACTGAGGCCACGACAAAGCACAGCTCCAGCTCGGACAGCACCCTCAGTGCCAGCCAGCCTCTGCCAGACCTCTCTTTCCCTCTTCTCCCC
AGCCTCCTCCAGGGCTGCCCAAGGCAGGGTTTCCAGCCAGGCCTCGGGGTCATCTTTTCACCAGGAGCAAACCCAAGTCTTAGTTGCTAC
AAGAAAATCCCCTGGAAGTACTGGGGGCCAGGTTCCCCAGACAGCAGGAATTGCCCCTGTTCAGAGCAGCCGGAGTTTGCTGGACCACAA
GGAAGAAGAGAAGAGACTTGCAGTGAACTGTTTTTGTGCCAAGAAACCCTGGACCTGGGGCCAAGTATTTCCCAAGCCAAGCATCCACTT
GTCTGTGTCTGGGAAGGGATGGCCAAGGCCGCTAGGGTCCTTACCCCTCAGGATCACTCCCCAGCCCTTTCCTCAGGAGGTACCGCTCTC
CAAGGTGTGCTAGCAGTGGGCCCTGCCCAACTTCAGGCAGAACAGGGAGGCCCAGAGATTACAGATCCCCTCCTGTAAGTGGCCAGGCAT
TCTCTCCCTGCCCTCTCTGGCCTCTGGGGTCATACTCACTTCTTTAGCCAGCCCCATCCCCTCCACCCCACACCTGAGTTCTTGCCTCCT
CCTTTTGGGGACACCCAAAACACTGCTTGTGAGAAGGAAGATGGAAGGTAAGTTCTGTCGTTCTTTCCCCAATCCCCAGGAATGGACAAG
AAGCCAACTTAGAAAGAAGGGTCTCACGTGGCTGGCCTGGCTCCTCCGTAGACCCCTGTTCTTTTCAACCTCTGCCCACCCGTGCATGTC
ATCACAAACATTTGCTCTTAAGTTACAAGAGACCACATCCACCCAGGGATTAGGGTTCAAGTAGCAGCTGCTAACCCTTGCACCAGCCCT
TGTGGGACTCCCAACACAAGACAAAGCTCAGGATGCTGGTGATGCTAGGAAGATGTCCCTCCCCTCACTGCCCCACATTCTCCCAGTGGC
TCTACCAGCCTCACCCATCAAACCAGTGAATTTCTCAATCTTGCCTCACAGTGACTGCAGCGCCAAGCGGCATCCACCAAGCATCAAGTT
GGAGAAAAGGGAACCCAAGCAGTAGAGAGCGATATTGGAGTCTTTTGTTCATTCAAATCTTGGATTTTTTTTTTTCCCTAAGAGATTCTC
TTTTTAGGGGGAATGGGAAACGGACACCTCATAAAGGGTTCAAAGATCATCAATTTTTCTGACTTTTTAAATCATTATCATTATTATTTT

>4675_4675_2_ANKRD28-TM9SF4_ANKRD28_chr3_15836730_ENST00000399451_TM9SF4_chr20_30720816_ENST00000398022_length(amino acids)=674AA_BP=36
MAFLKLRDQPSLVQAIFNGDPDEVRALIFKKEDVNFQDWLPWSLLLFSLMCETSAFYVPGVAPINFHQNDPVEIKAVKLTSSRTQLPYEY
YSLPFCQPSKITYKAENLGEVLRGDRIVNTPFQVLMNSEKKCEVLCSQSNKPVTLTVEQSRLVAERITEDYYVHLIADNLPVATRLELYS
NRDSDDKKKEKDVQFEHGYRLGFTDVNKIYLHNHLSFILYYHREDMEEDQEHTYRVVRFEVIPQSIRLEDLKADEKSSCTLPEGTNSSPQ
EIDPTKENQLYFTYSVHWEESDIKWASRWDTYLTMSDVQIHWFSIINSVVVVFFLSGILSMIIIRTLRKDIANYNKEDDIEDTMEESGWK
LVHGDVFRPPQYPMILSSLLGSGIQLFCMILIVIFVAMLGMLSPSSRGALMTTACFLFMFMGVFGGFSAGRLYRTLKGHRWKKGAFCTAT
LYPGVVFGICFVLNCFIWGKHSSGAVPFPTMVALLCMWFGISLPLVYLGYYFGFRKQPYDNPVRTNQIPRQIPEQRWYMNRFVGILMAGI
LPFGAMFIELFFIFSAIWENQFYYLFGFLFLVFIILVVSCSQISIVMVYFQLCAEDYRWWWRNFLVSGGSAFYVLVYAIFYFVNKLDIVE

--------------------------------------------------------------

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Fusion Gene PPI Analysis for ANKRD28-TM9SF4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ANKRD28-TM9SF4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ANKRD28-TM9SF4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource