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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ASTN2-TMEM38B (FusionGDB2 ID:HG23245TG55151)

Fusion Gene Summary for ASTN2-TMEM38B

check button Fusion gene summary
Fusion gene informationFusion gene name: ASTN2-TMEM38B
Fusion gene ID: hg23245tg55151
HgeneTgene
Gene symbol

ASTN2

TMEM38B

Gene ID

23245

55151

Gene nameastrotactin 2transmembrane protein 38B
SynonymsbA67K19.1C9orf87|D4Ertd89e|OI14|TRIC-B|TRICB|bA219P18.1
Cytomap('ASTN2')('TMEM38B')

9q33.1

9q31.2

Type of geneprotein-codingprotein-coding
Descriptionastrotactin-2trimeric intracellular cation channel type B
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000313400, ENST00000361209, 
ENST00000373996, ENST00000361477, 
ENST00000288520, ENST00000341734, 
ENST00000358637, 
Fusion gene scores* DoF score16 X 19 X 6=18247 X 5 X 6=210
# samples 197
** MAII scorelog2(19/1824*10)=-3.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(7/210*10)=-1.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ASTN2 [Title/Abstract] AND TMEM38B [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointASTN2(119858323)-TMEM38B(108467878), # samples:1
Anticipated loss of major functional domain due to fusion event.ASTN2-TMEM38B seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ASTN2-TMEM38B seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across ASTN2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across TMEM38B (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LGGTCGA-DU-A6S7-01AASTN2chr9

119858323

-TMEM38Bchr9

108467878

+


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Fusion Gene ORF analysis for ASTN2-TMEM38B

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000313400ENST00000374688ASTN2chr9

119858323

-TMEM38Bchr9

108467878

+
5CDS-5UTRENST00000361209ENST00000374688ASTN2chr9

119858323

-TMEM38Bchr9

108467878

+
5CDS-5UTRENST00000373996ENST00000374688ASTN2chr9

119858323

-TMEM38Bchr9

108467878

+
5UTR-3CDSENST00000361477ENST00000374692ASTN2chr9

119858323

-TMEM38Bchr9

108467878

+
5UTR-5UTRENST00000361477ENST00000374688ASTN2chr9

119858323

-TMEM38Bchr9

108467878

+
In-frameENST00000313400ENST00000374692ASTN2chr9

119858323

-TMEM38Bchr9

108467878

+
In-frameENST00000361209ENST00000374692ASTN2chr9

119858323

-TMEM38Bchr9

108467878

+
In-frameENST00000373996ENST00000374692ASTN2chr9

119858323

-TMEM38Bchr9

108467878

+
intron-3CDSENST00000288520ENST00000374692ASTN2chr9

119858323

-TMEM38Bchr9

108467878

+
intron-3CDSENST00000341734ENST00000374692ASTN2chr9

119858323

-TMEM38Bchr9

108467878

+
intron-3CDSENST00000358637ENST00000374692ASTN2chr9

119858323

-TMEM38Bchr9

108467878

+
intron-5UTRENST00000288520ENST00000374688ASTN2chr9

119858323

-TMEM38Bchr9

108467878

+
intron-5UTRENST00000341734ENST00000374688ASTN2chr9

119858323

-TMEM38Bchr9

108467878

+
intron-5UTRENST00000358637ENST00000374688ASTN2chr9

119858323

-TMEM38Bchr9

108467878

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000373996ASTN2chr9119858323-ENST00000374692TMEM38Bchr9108467878+4572127602039679
ENST00000313400ASTN2chr9119858323-ENST00000374692TMEM38Bchr9108467878+467313771012140679
ENST00000361209ASTN2chr9119858323-ENST00000374692TMEM38Bchr9108467878+455112551322018628

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000373996ENST00000374692ASTN2chr9119858323-TMEM38Bchr9108467878+0.0014176750.99858236
ENST00000313400ENST00000374692ASTN2chr9119858323-TMEM38Bchr9108467878+0.0016738940.9983261
ENST00000361209ENST00000374692ASTN2chr9119858323-TMEM38Bchr9108467878+0.0020939440.9979061

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Fusion Genomic Features for ASTN2-TMEM38B


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
ASTN2chr9119858322-TMEM38Bchr9108467877+0.0001531360.9998468
ASTN2chr9119858322-TMEM38Bchr9108467877+0.0001531360.9998468

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for ASTN2-TMEM38B


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr9:119858323/chr9:108467878)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneASTN2chr9:119858323chr9:108467878ENST00000313400-52350_2064251340.0Topological domainLumenal
HgeneASTN2chr9:119858323chr9:108467878ENST00000361209-42250_2063741289.0Topological domainLumenal
HgeneASTN2chr9:119858323chr9:108467878ENST00000373996-52350_2064251336.0Topological domainLumenal
HgeneASTN2chr9:119858323chr9:108467878ENST00000313400-523207_2274251340.0TransmembraneHelical
HgeneASTN2chr9:119858323chr9:108467878ENST00000361209-422207_2273741289.0TransmembraneHelical
HgeneASTN2chr9:119858323chr9:108467878ENST00000373996-523207_2274251336.0TransmembraneHelical
TgeneTMEM38Bchr9:119858323chr9:108467878ENST0000037469206100_10437292.0Topological domainCytoplasmic
TgeneTMEM38Bchr9:119858323chr9:108467878ENST0000037469206122_13937292.0Topological domainLumenal
TgeneTMEM38Bchr9:119858323chr9:108467878ENST0000037469206157_17937292.0Topological domainCytoplasmic
TgeneTMEM38Bchr9:119858323chr9:108467878ENST0000037469206196_20737292.0Topological domainLumenal
TgeneTMEM38Bchr9:119858323chr9:108467878ENST0000037469206228_29137292.0Topological domainCytoplasmic
TgeneTMEM38Bchr9:119858323chr9:108467878ENST000003746920671_8237292.0Topological domainLumenal
TgeneTMEM38Bchr9:119858323chr9:108467878ENST0000037469206105_12137292.0TransmembraneHelical%3BName%3D4
TgeneTMEM38Bchr9:119858323chr9:108467878ENST0000037469206140_15637292.0TransmembraneHelical%3BName%3D5
TgeneTMEM38Bchr9:119858323chr9:108467878ENST0000037469206180_19537292.0TransmembraneHelical%3BName%3D6
TgeneTMEM38Bchr9:119858323chr9:108467878ENST0000037469206208_22737292.0TransmembraneHelical%3BName%3D7
TgeneTMEM38Bchr9:119858323chr9:108467878ENST000003746920651_7037292.0TransmembraneHelical%3BName%3D2
TgeneTMEM38Bchr9:119858323chr9:108467878ENST000003746920683_9937292.0TransmembraneHelical%3BName%3D3

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneASTN2chr9:119858323chr9:108467878ENST00000288520-181065_11880441.0DomainNote=Fibronectin type-III
HgeneASTN2chr9:119858323chr9:108467878ENST00000288520-18510_5500441.0DomainNote=EGF-like 1
HgeneASTN2chr9:119858323chr9:108467878ENST00000288520-18651_6950441.0DomainNote=EGF-like 2
HgeneASTN2chr9:119858323chr9:108467878ENST00000288520-18699_7510441.0DomainNote=EGF-like 3
HgeneASTN2chr9:119858323chr9:108467878ENST00000313400-5231065_11884251340.0DomainNote=Fibronectin type-III
HgeneASTN2chr9:119858323chr9:108467878ENST00000313400-523510_5504251340.0DomainNote=EGF-like 1
HgeneASTN2chr9:119858323chr9:108467878ENST00000313400-523651_6954251340.0DomainNote=EGF-like 2
HgeneASTN2chr9:119858323chr9:108467878ENST00000313400-523699_7514251340.0DomainNote=EGF-like 3
HgeneASTN2chr9:119858323chr9:108467878ENST00000341734-191065_11880396.0DomainNote=Fibronectin type-III
HgeneASTN2chr9:119858323chr9:108467878ENST00000341734-19510_5500396.0DomainNote=EGF-like 1
HgeneASTN2chr9:119858323chr9:108467878ENST00000341734-19651_6950396.0DomainNote=EGF-like 2
HgeneASTN2chr9:119858323chr9:108467878ENST00000341734-19699_7510396.0DomainNote=EGF-like 3
HgeneASTN2chr9:119858323chr9:108467878ENST00000361209-4221065_11883741289.0DomainNote=Fibronectin type-III
HgeneASTN2chr9:119858323chr9:108467878ENST00000361209-422510_5503741289.0DomainNote=EGF-like 1
HgeneASTN2chr9:119858323chr9:108467878ENST00000361209-422651_6953741289.0DomainNote=EGF-like 2
HgeneASTN2chr9:119858323chr9:108467878ENST00000361209-422699_7513741289.0DomainNote=EGF-like 3
HgeneASTN2chr9:119858323chr9:108467878ENST00000361477-4231065_11880396.0DomainNote=Fibronectin type-III
HgeneASTN2chr9:119858323chr9:108467878ENST00000361477-423510_5500396.0DomainNote=EGF-like 1
HgeneASTN2chr9:119858323chr9:108467878ENST00000361477-423651_6950396.0DomainNote=EGF-like 2
HgeneASTN2chr9:119858323chr9:108467878ENST00000361477-423699_7510396.0DomainNote=EGF-like 3
HgeneASTN2chr9:119858323chr9:108467878ENST00000373996-5231065_11884251336.0DomainNote=Fibronectin type-III
HgeneASTN2chr9:119858323chr9:108467878ENST00000373996-523510_5504251336.0DomainNote=EGF-like 1
HgeneASTN2chr9:119858323chr9:108467878ENST00000373996-523651_6954251336.0DomainNote=EGF-like 2
HgeneASTN2chr9:119858323chr9:108467878ENST00000373996-523699_7514251336.0DomainNote=EGF-like 3
HgeneASTN2chr9:119858323chr9:108467878ENST00000288520-18228_4340441.0Topological domainCytoplasmic
HgeneASTN2chr9:119858323chr9:108467878ENST00000288520-18456_13390441.0Topological domainLumenal
HgeneASTN2chr9:119858323chr9:108467878ENST00000288520-1850_2060441.0Topological domainLumenal
HgeneASTN2chr9:119858323chr9:108467878ENST00000313400-523228_4344251340.0Topological domainCytoplasmic
HgeneASTN2chr9:119858323chr9:108467878ENST00000313400-523456_13394251340.0Topological domainLumenal
HgeneASTN2chr9:119858323chr9:108467878ENST00000341734-19228_4340396.0Topological domainCytoplasmic
HgeneASTN2chr9:119858323chr9:108467878ENST00000341734-19456_13390396.0Topological domainLumenal
HgeneASTN2chr9:119858323chr9:108467878ENST00000341734-1950_2060396.0Topological domainLumenal
HgeneASTN2chr9:119858323chr9:108467878ENST00000361209-422228_4343741289.0Topological domainCytoplasmic
HgeneASTN2chr9:119858323chr9:108467878ENST00000361209-422456_13393741289.0Topological domainLumenal
HgeneASTN2chr9:119858323chr9:108467878ENST00000361477-423228_4340396.0Topological domainCytoplasmic
HgeneASTN2chr9:119858323chr9:108467878ENST00000361477-423456_13390396.0Topological domainLumenal
HgeneASTN2chr9:119858323chr9:108467878ENST00000361477-42350_2060396.0Topological domainLumenal
HgeneASTN2chr9:119858323chr9:108467878ENST00000373996-523228_4344251336.0Topological domainCytoplasmic
HgeneASTN2chr9:119858323chr9:108467878ENST00000373996-523456_13394251336.0Topological domainLumenal
HgeneASTN2chr9:119858323chr9:108467878ENST00000288520-18207_2270441.0TransmembraneHelical
HgeneASTN2chr9:119858323chr9:108467878ENST00000288520-18435_4550441.0TransmembraneHelical
HgeneASTN2chr9:119858323chr9:108467878ENST00000313400-523435_4554251340.0TransmembraneHelical
HgeneASTN2chr9:119858323chr9:108467878ENST00000341734-19207_2270396.0TransmembraneHelical
HgeneASTN2chr9:119858323chr9:108467878ENST00000341734-19435_4550396.0TransmembraneHelical
HgeneASTN2chr9:119858323chr9:108467878ENST00000361209-422435_4553741289.0TransmembraneHelical
HgeneASTN2chr9:119858323chr9:108467878ENST00000361477-423207_2270396.0TransmembraneHelical
HgeneASTN2chr9:119858323chr9:108467878ENST00000361477-423435_4550396.0TransmembraneHelical
HgeneASTN2chr9:119858323chr9:108467878ENST00000373996-523435_4554251336.0TransmembraneHelical
TgeneTMEM38Bchr9:119858323chr9:108467878ENST00000374692061_1937292.0Topological domainLumenal
TgeneTMEM38Bchr9:119858323chr9:108467878ENST000003746920634_5037292.0Topological domainCytoplasmic
TgeneTMEM38Bchr9:119858323chr9:108467878ENST000003746920620_3337292.0TransmembraneHelical%3BName%3D1


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Fusion Gene Sequence for ASTN2-TMEM38B


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>7279_7279_1_ASTN2-TMEM38B_ASTN2_chr9_119858323_ENST00000313400_TMEM38B_chr9_108467878_ENST00000374692_length(transcript)=4673nt_BP=1377nt
GGTTCGCTTCGGCGTCCGCCGTCTCCGCAGCTGCCTCCTCTTCCTCCTTCGCCACCGCCGCCACCGCCGCCGCCGCCCGCAGCACCGCAG
CCCCTCCCGCCATGGCCGCCGCCGGCGCCCGGCTCAGCCCCGGCCCCGGCTCGGGGCTCCGGGGGCGGCCGAGGCTCTGCTTCCACCCGG
GGCCGCCGCCACTGCTGCCGCTGCTGCTGCTGTTCCTGCTCCTGCTGCCGCCGCCGCCGCTGCTGGCCGGCGCCACCGCCGCTGCCTCGC
GGGAGCCCGACAGCCCGTGCCGGCTGAAGACCGTCACGGTGTCCACACTGCCCGCCCTGCGGGAGAGCGACATCGGCTGGAGCGGCGCCC
GCGCCGGGGCCGGGGCTGGGACCGGGGCCGGAGCCGCCGCCGCCGCCGCGTCCCCGGGCTCTCCTGGCTCTGCCGGCACCGCCGCCGAGT
CGCGCCTCCTGCTCTTTGTGCGTAACGAGCTGCCGGGGCGCATCGCGGTGCAGGACGACCTGGACAACACCGAGCTGCCCTTCTTCACCC
TGGAGATGTCTGGCACAGCAGCGGACATCTCGCTGGTGCACTGGAGACAGCAGTGGCTGGAGAATGGCACCTTGTACTTCCACGTCTCCA
TGAGCAGCTCCGGGCAGCTGGCCCAAGCCACCGCCCCCACTCTCCAGGAGCCCTCGGAGATTGTTGAGGAGCAGATGCACATCCTCCACA
TTTCTGTGATGGGTGGCCTCATCGCGCTGCTGCTGCTGCTGCTGGTGTTCACCGTGGCGCTGTACGCCCAGCGACGTTGGCAGAAGCGTC
GCCGCATCCCCCAGAAGAGCGCAAGCACAGAAGCCACTCATGAGATCCACTACATCCCATCTGTGCTGCTGGGTCCCCAGGCGCGGGAGA
GCTTCCGTTCATCCCGGCTGCAAACCCACAATTCCGTCATTGGCGTGCCCATCCGGGAGACTCCCATCCTGGATGACTATGACTGTGAGG
AGGATGAGGAGCCACCTAGGCGGGCCAACCATGTCTCCCGCGAGGACGAGTTTGGCAGCCAGGTGACCCACACTCTGGACAGTCTGGGAC
ATCCAGGGGAAGAGAAGGTGGACTTTGAGAAGAAAGCAGCAGCTGAGGCGACTCAGGAGACAGTGGAGTCCCTGATGCAGAAGTTCAAGG
AGAGTTTCCGCGCTAACACGCCCATCGAGATCGGTCAGCTGCAACCACCCCTGCGCAGCACATCGGCAGGGAAGAGGAAGCGGAGGAGCA
AGTCTCGAGGAGGAATCAGCTTTGGGAGAGCCAAGGGGACGTCGGGCTCAGAGGCAGACGATGAAACTCAGCTGACATTCTACACGGAGC
AGTACCGCAGTCGCCGCCGCAGCAAAGGAGCAGCTGCATTGGCATGGAAGAATCCTATTTCAAGCTGGTTTACTGCTATGCTCCACTGTT
TTGGTGGAGGAATTTTATCCTGTCTACTGCTTGCAGAGCCTCCATTGAAGTTTCTTGCAAACCACACTAACATATTACTGGCATCTTCAA
TCTGGTATATTACATTTTTTTGCCCGCATGACCTAGTTTCCCAGGGCTATTCATATCTACCTGTTCAACTACTGGCTTCGGGAATGAAGG
AAGTGACCAGAACTTGGAAAATAGTAGGTGGAGTCACACATGCTAATAGCTATTACAAAAATGGCTGGATAGTCATGATAGCTATTGGAT
GGGCCCGAGGTGCAGGTGGTACCATTATAACGAATTTTGAGAGGTTGGTAAAAGGAGATTGGAAACCAGAAGGTGATGAATGGCTGAAGA
TGTCATACCCTGCCAAGGTAACCCTGCTGGGGTCAGTTATCTTCACATTCCAGCACACCCAGCATCTGGCAATATCAAAGCATAATCTTA
TGTTCCTTTATACCATCTTTATTGTGGCCACAAAGATAACCATGATGACTACACAGACTTCTACTATGACATTTGCTCCTTTTGAGGATA
CATTGAGTTGGATGCTATTTGGCTGGCAGCAGCCGTTTTCATCATGTGAGAAGAAAAGTGAAGCAAAGTCACCTTCCAATGGCGTTGGGT
CATTGGCCTCAAAGCCGGTAGATGTTGCCTCAGATAATGTTAAAAAGAAACATACTAAGAAGAATGAATAAATTTACGTGATGAGCTCTA
CAAGGCCAAAAATTTTTTTTCTTATCTACCTGTTATATTGTGCTAATTTTTCTATGTATGTGATGTGAAATGAAGACTATATATATGGAA
TGGAGGTGACAGAAAGAAAGAAATTCTTTGTTTGAGGGAGACTTCCCCTTTCTGGATTGTATTTGTAGAGTGTTACGAGTGTATCATGTG
ATTATGCTTTACCGGTATAAGAGATTCTGTTGTGATTATTTGAATAGTTTTATATTAATAAAAGAAGACAAAATTTTTTAAATGTTAGAA
AAAGCAGATCTGTCATTGCAAAGTAACAAAAATTTTAAGCTTTTAAAAATGTAGATTTTTCATATTTTTAAAATTTGAATCTATTTGAGC
TTTAGTTCAGCAGAATTAAATTTTTACTTGACATTATCATTAAAATTGCTAGGTATGGAGAACAATTCCTATTTTATTTTGAACACTGAG
AAGAGTAAACTTTTCCTAAAACACTTTATATTATAAATGAAAATAAATTGCTAGTTTATATTTTAGATATAAACATCATATTTTTTATTA
ATACCTACATCAAATGGAAAATATCTGAAATTTTTTTTCCATAGCAGGTATTTTCTACTAGAAGTAGTTTTACTACTTTTCATTTAGAAC
AGAGTATGAGTCTTAATCTGAAGTCTTTTTCATGCCCTTGTTTTAAAAAAACTACTTTTTTTGGCCTCAAAAAAATCAAGGGTGTAATTT
TTAATAAATTGTTAATCCTATGTTTTGTAATTTTCATTTTAGGAGCTTGACTTATTTTTTTCTCTCTCATAAAAACACATTTGTTTTAAT
TGTAGGAGAAATTTTCTCAGCATTTTGCATGTTCTTTCTAATCTTTGTTGGTCTGAATATATTGGTAGTAATTACTGTAATTATTCAACA
AAAAGCATATCCGTTCAAAAATTTTTCCACTATGTCTTTTTTCTAGTGGCTACTGTTTTAGTTTTCTAGTTGAATATCTCTGACAAGCTT
TCGTATGGTTTTGTTATATTTTCATCTACATGTAATGTGTTATTAATTTTATTAAATGAAAACTAATCACCTTCATGTGGAAATGCTCTG
AGAATTGTCCTTAGGCATTTGGTAGTAACCAGCTAACCAAGAAGAAACAGAGAAACCAGAACTTCATATGGCAGTCCATTTAGATGAAGA
ATGATGATATAAAATCTGGTTCCTTCTTAGCAAAATAAAAAACAAACAAGAAAAGATACTAAATGATGTTAATTTTCTTACTTTATGATT
TAGAAGTCCAGTTATAATATTAAAACTCTGTGACATAGTTTCTTTTACCAAAACCATGAACCTACTCCCCGTATCAGGTATTTTCGATGG
TTTAGAAGTACTCAAGTCACATCACATTCAAGTTAGAAGTTTTTTTTTTGTTGTTGTTATTTTAAATTTTTAACAAATATAAACACCAGC
AGATACTATTACTTGCTTAAAAAATTGGGAGGGGGCACTTTTCATAGTCTTGGAATGCTAAGAAGTTTTATTTTTAATATTGTGACAGAA
AGCTTTAAGTATTTAAGAGCTCTGTATTATATTTGATACTCTTACAGTTAAAAACTTTTCAAAATTAATACATTGTTAATTATTGACCAG
TTTTGAAGTTTGGGTTTAACTGTAGTTGAAATGGAAGGACTCTTGTTTTACACTTGTATTAAAGATAAATTTATTAAAATAAGTTATTTA
GCACCAATGGAGTATTACATTATTTTTATGTTTTATATTTTTCTTGAGGTAGAGTTTCAGAACTCATCTAGTATTTTGACTAATATAGTA
TATATTCAGTGATTACTGTTCAAATGGGACATTGGTAGAAACTTTATTAATCTATGCAAGTATCCTATAACCCTCAATTCAAGGCTCTTT
TGTAAAAAATGTACTGGAGAACATGGCTTAGGCCTGAAACCCATCCTGAATCTATTCAGGTCACCTGTAGAGTCTTGACTTGGATTTGCA
AAGCAGATTGTTAGACTCCTTACCCAATGTGAAGTGTGAATAAGGCCTATAGGCCTGCCTCACACAGCTAATCAGAGGTGGCACTGAGAA
AGTCAAGTCCTAATAGGTCTCCTTAAAAAAAAAAAGGAGACAAAAAGCTGGCAAGAACATGAGCCAGCTTCCCTCAGTGCTGTCACTCTC
AAGTAAAACATGGCCAAATGAATATCAAACTGGTTTATCAGATTAGTCACTCTTCCTTACTGAGGGAGTATCAAGTAAGGGCTGGAGAGA
GACCAGATATGTGGAGTTGTTGGCTTTCAGTGGAAATGGTAGCCTCCCTGTGGGTAGAGACCAAAAGGTAGAGAGATGACAGAAGGGAGA
CTCTGATTAGTGTATTTTTTTTTTGTCTATTCCTTAAAGCCCAGACACCTTTCCATTAAAATCTACTTCAAATCACAAGTTGATTACAAT

>7279_7279_1_ASTN2-TMEM38B_ASTN2_chr9_119858323_ENST00000313400_TMEM38B_chr9_108467878_ENST00000374692_length(amino acids)=679AA_BP=425
MAAAGARLSPGPGSGLRGRPRLCFHPGPPPLLPLLLLFLLLLPPPPLLAGATAAASREPDSPCRLKTVTVSTLPALRESDIGWSGARAGA
GAGTGAGAAAAAASPGSPGSAGTAAESRLLLFVRNELPGRIAVQDDLDNTELPFFTLEMSGTAADISLVHWRQQWLENGTLYFHVSMSSS
GQLAQATAPTLQEPSEIVEEQMHILHISVMGGLIALLLLLLVFTVALYAQRRWQKRRRIPQKSASTEATHEIHYIPSVLLGPQARESFRS
SRLQTHNSVIGVPIRETPILDDYDCEEDEEPPRRANHVSREDEFGSQVTHTLDSLGHPGEEKVDFEKKAAAEATQETVESLMQKFKESFR
ANTPIEIGQLQPPLRSTSAGKRKRRSKSRGGISFGRAKGTSGSEADDETQLTFYTEQYRSRRRSKGAAALAWKNPISSWFTAMLHCFGGG
ILSCLLLAEPPLKFLANHTNILLASSIWYITFFCPHDLVSQGYSYLPVQLLASGMKEVTRTWKIVGGVTHANSYYKNGWIVMIAIGWARG
AGGTIITNFERLVKGDWKPEGDEWLKMSYPAKVTLLGSVIFTFQHTQHLAISKHNLMFLYTIFIVATKITMMTTQTSTMTFAPFEDTLSW

--------------------------------------------------------------
>7279_7279_2_ASTN2-TMEM38B_ASTN2_chr9_119858323_ENST00000361209_TMEM38B_chr9_108467878_ENST00000374692_length(transcript)=4551nt_BP=1255nt
GGCTCTCTCCGCTCCTTAGCTCGGGCGTCCTGGTTCGCTTCGGCGTCCGCCGTCTCCGCAGCTGCCTCCTCTTCCTCCTTCGCCACCGCC
GCCACCGCCGCCGCCGCCCGCAGCACCGCAGCCCCTCCCGCCATGGCCGCCGCCGGCGCCCGGCTCAGCCCCGGCCCCGGCTCGGGGCTC
CGGGGGCGGCCGAGGCTCTGCTTCCACCCGGGGCCGCCGCCACTGCTGCCGCTGCTGCTGCTGTTCCTGCTCCTGCTGCCGCCGCCGCCG
CTGCTGGCCGGCGCCACCGCCGCTGCCTCGCGGGAGCCCGACAGCCCGTGCCGGCTGAAGACCGTCACGGTGTCCACACTGCCCGCCCTG
CGGGAGAGCGACATCGGCTGGAGCGGCGCCCGCGCCGGGGCCGGGGCTGGGACCGGGGCCGGAGCCGCCGCCGCCGCCGCGTCCCCGGGC
TCTCCTGGCTCTGCCGGCACCGCCGCCGAGTCGCGCCTCCTGCTCTTTGTGCGTAACGAGCTGCCGGGGCGCATCGCGGTGCAGGACGAC
CTGGACAACACCGAGCTGCCCTTCTTCACCCTGGAGATGTCTGGCACAGCAGCGGACATCTCGCTGGTGCACTGGAGACAGCAGTGGCTG
GAGAATGGCACCTTGTACTTCCACGTCTCCATGAGCAGCTCCGGGCAGCTGGCCCAAGCCACCGCCCCCACTCTCCAGGAGCCCTCGGAG
ATTGTTGAGGAGCAGATGCACATCCTCCACATTTCTGTGATGGGTGGCCTCATCGCGCTGCTGCTGCTGCTGCTGGTGTTCACCGTGGCG
CTGTACGCCCAGCGACGTTGGCAGAAGCGTCGCCGCATCCCCCAGAAGAGCGCAAGCACAGAAGCCACTCATGAGATCCACTACATCCCA
TCTGTGCTGCTGGGTCCCCAGGCGCGGGAGAGCTTCCGTTCATCCCGGCTGCAAACCCACAATTCCGTCATTGGCGTGCCCATCCGGGAG
ACTCCCATCCTGGATGACTATGACTGTGAGGAGGATGAGGAGCCACCTAGGCGGGCCAACCATGTCTCCCGCGAGGACGAGTTTGGCAGC
CAGGTGACCCACACTCTGGACAGTCTGGGACATCCAGGGGAAGAGAAGGTGGACTTTGAGAAGAAAGGAGGAATCAGCTTTGGGAGAGCC
AAGGGGACGTCGGGCTCAGAGGCAGACGATGAAACTCAGCTGACATTCTACACGGAGCAGTACCGCAGTCGCCGCCGCAGCAAAGGAGCA
GCTGCATTGGCATGGAAGAATCCTATTTCAAGCTGGTTTACTGCTATGCTCCACTGTTTTGGTGGAGGAATTTTATCCTGTCTACTGCTT
GCAGAGCCTCCATTGAAGTTTCTTGCAAACCACACTAACATATTACTGGCATCTTCAATCTGGTATATTACATTTTTTTGCCCGCATGAC
CTAGTTTCCCAGGGCTATTCATATCTACCTGTTCAACTACTGGCTTCGGGAATGAAGGAAGTGACCAGAACTTGGAAAATAGTAGGTGGA
GTCACACATGCTAATAGCTATTACAAAAATGGCTGGATAGTCATGATAGCTATTGGATGGGCCCGAGGTGCAGGTGGTACCATTATAACG
AATTTTGAGAGGTTGGTAAAAGGAGATTGGAAACCAGAAGGTGATGAATGGCTGAAGATGTCATACCCTGCCAAGGTAACCCTGCTGGGG
TCAGTTATCTTCACATTCCAGCACACCCAGCATCTGGCAATATCAAAGCATAATCTTATGTTCCTTTATACCATCTTTATTGTGGCCACA
AAGATAACCATGATGACTACACAGACTTCTACTATGACATTTGCTCCTTTTGAGGATACATTGAGTTGGATGCTATTTGGCTGGCAGCAG
CCGTTTTCATCATGTGAGAAGAAAAGTGAAGCAAAGTCACCTTCCAATGGCGTTGGGTCATTGGCCTCAAAGCCGGTAGATGTTGCCTCA
GATAATGTTAAAAAGAAACATACTAAGAAGAATGAATAAATTTACGTGATGAGCTCTACAAGGCCAAAAATTTTTTTTCTTATCTACCTG
TTATATTGTGCTAATTTTTCTATGTATGTGATGTGAAATGAAGACTATATATATGGAATGGAGGTGACAGAAAGAAAGAAATTCTTTGTT
TGAGGGAGACTTCCCCTTTCTGGATTGTATTTGTAGAGTGTTACGAGTGTATCATGTGATTATGCTTTACCGGTATAAGAGATTCTGTTG
TGATTATTTGAATAGTTTTATATTAATAAAAGAAGACAAAATTTTTTAAATGTTAGAAAAAGCAGATCTGTCATTGCAAAGTAACAAAAA
TTTTAAGCTTTTAAAAATGTAGATTTTTCATATTTTTAAAATTTGAATCTATTTGAGCTTTAGTTCAGCAGAATTAAATTTTTACTTGAC
ATTATCATTAAAATTGCTAGGTATGGAGAACAATTCCTATTTTATTTTGAACACTGAGAAGAGTAAACTTTTCCTAAAACACTTTATATT
ATAAATGAAAATAAATTGCTAGTTTATATTTTAGATATAAACATCATATTTTTTATTAATACCTACATCAAATGGAAAATATCTGAAATT
TTTTTTCCATAGCAGGTATTTTCTACTAGAAGTAGTTTTACTACTTTTCATTTAGAACAGAGTATGAGTCTTAATCTGAAGTCTTTTTCA
TGCCCTTGTTTTAAAAAAACTACTTTTTTTGGCCTCAAAAAAATCAAGGGTGTAATTTTTAATAAATTGTTAATCCTATGTTTTGTAATT
TTCATTTTAGGAGCTTGACTTATTTTTTTCTCTCTCATAAAAACACATTTGTTTTAATTGTAGGAGAAATTTTCTCAGCATTTTGCATGT
TCTTTCTAATCTTTGTTGGTCTGAATATATTGGTAGTAATTACTGTAATTATTCAACAAAAAGCATATCCGTTCAAAAATTTTTCCACTA
TGTCTTTTTTCTAGTGGCTACTGTTTTAGTTTTCTAGTTGAATATCTCTGACAAGCTTTCGTATGGTTTTGTTATATTTTCATCTACATG
TAATGTGTTATTAATTTTATTAAATGAAAACTAATCACCTTCATGTGGAAATGCTCTGAGAATTGTCCTTAGGCATTTGGTAGTAACCAG
CTAACCAAGAAGAAACAGAGAAACCAGAACTTCATATGGCAGTCCATTTAGATGAAGAATGATGATATAAAATCTGGTTCCTTCTTAGCA
AAATAAAAAACAAACAAGAAAAGATACTAAATGATGTTAATTTTCTTACTTTATGATTTAGAAGTCCAGTTATAATATTAAAACTCTGTG
ACATAGTTTCTTTTACCAAAACCATGAACCTACTCCCCGTATCAGGTATTTTCGATGGTTTAGAAGTACTCAAGTCACATCACATTCAAG
TTAGAAGTTTTTTTTTTGTTGTTGTTATTTTAAATTTTTAACAAATATAAACACCAGCAGATACTATTACTTGCTTAAAAAATTGGGAGG
GGGCACTTTTCATAGTCTTGGAATGCTAAGAAGTTTTATTTTTAATATTGTGACAGAAAGCTTTAAGTATTTAAGAGCTCTGTATTATAT
TTGATACTCTTACAGTTAAAAACTTTTCAAAATTAATACATTGTTAATTATTGACCAGTTTTGAAGTTTGGGTTTAACTGTAGTTGAAAT
GGAAGGACTCTTGTTTTACACTTGTATTAAAGATAAATTTATTAAAATAAGTTATTTAGCACCAATGGAGTATTACATTATTTTTATGTT
TTATATTTTTCTTGAGGTAGAGTTTCAGAACTCATCTAGTATTTTGACTAATATAGTATATATTCAGTGATTACTGTTCAAATGGGACAT
TGGTAGAAACTTTATTAATCTATGCAAGTATCCTATAACCCTCAATTCAAGGCTCTTTTGTAAAAAATGTACTGGAGAACATGGCTTAGG
CCTGAAACCCATCCTGAATCTATTCAGGTCACCTGTAGAGTCTTGACTTGGATTTGCAAAGCAGATTGTTAGACTCCTTACCCAATGTGA
AGTGTGAATAAGGCCTATAGGCCTGCCTCACACAGCTAATCAGAGGTGGCACTGAGAAAGTCAAGTCCTAATAGGTCTCCTTAAAAAAAA
AAAGGAGACAAAAAGCTGGCAAGAACATGAGCCAGCTTCCCTCAGTGCTGTCACTCTCAAGTAAAACATGGCCAAATGAATATCAAACTG
GTTTATCAGATTAGTCACTCTTCCTTACTGAGGGAGTATCAAGTAAGGGCTGGAGAGAGACCAGATATGTGGAGTTGTTGGCTTTCAGTG
GAAATGGTAGCCTCCCTGTGGGTAGAGACCAAAAGGTAGAGAGATGACAGAAGGGAGACTCTGATTAGTGTATTTTTTTTTTGTCTATTC
CTTAAAGCCCAGACACCTTTCCATTAAAATCTACTTCAAATCACAAGTTGATTACAATTGAGTGGAACATCCCATGTTGTAAATGGAATA

>7279_7279_2_ASTN2-TMEM38B_ASTN2_chr9_119858323_ENST00000361209_TMEM38B_chr9_108467878_ENST00000374692_length(amino acids)=628AA_BP=374
MAAAGARLSPGPGSGLRGRPRLCFHPGPPPLLPLLLLFLLLLPPPPLLAGATAAASREPDSPCRLKTVTVSTLPALRESDIGWSGARAGA
GAGTGAGAAAAAASPGSPGSAGTAAESRLLLFVRNELPGRIAVQDDLDNTELPFFTLEMSGTAADISLVHWRQQWLENGTLYFHVSMSSS
GQLAQATAPTLQEPSEIVEEQMHILHISVMGGLIALLLLLLVFTVALYAQRRWQKRRRIPQKSASTEATHEIHYIPSVLLGPQARESFRS
SRLQTHNSVIGVPIRETPILDDYDCEEDEEPPRRANHVSREDEFGSQVTHTLDSLGHPGEEKVDFEKKGGISFGRAKGTSGSEADDETQL
TFYTEQYRSRRRSKGAAALAWKNPISSWFTAMLHCFGGGILSCLLLAEPPLKFLANHTNILLASSIWYITFFCPHDLVSQGYSYLPVQLL
ASGMKEVTRTWKIVGGVTHANSYYKNGWIVMIAIGWARGAGGTIITNFERLVKGDWKPEGDEWLKMSYPAKVTLLGSVIFTFQHTQHLAI

--------------------------------------------------------------
>7279_7279_3_ASTN2-TMEM38B_ASTN2_chr9_119858323_ENST00000373996_TMEM38B_chr9_108467878_ENST00000374692_length(transcript)=4572nt_BP=1276nt
ATGGCCGCCGCCGGCGCCCGGCTCAGCCCCGGCCCCGGCTCGGGGCTCCGGGGGCGGCCGAGGCTCTGCTTCCACCCGGGGCCGCCGCCA
CTGCTGCCGCTGCTGCTGCTGTTCCTGCTCCTGCTGCCGCCGCCGCCGCTGCTGGCCGGCGCCACCGCCGCTGCCTCGCGGGAGCCCGAC
AGCCCGTGCCGGCTGAAGACCGTCACGGTGTCCACACTGCCCGCCCTGCGGGAGAGCGACATCGGCTGGAGCGGCGCCCGCGCCGGGGCC
GGGGCTGGGACCGGGGCCGGAGCCGCCGCCGCCGCCGCGTCCCCGGGCTCTCCTGGCTCTGCCGGCACCGCCGCCGAGTCGCGCCTCCTG
CTCTTTGTGCGTAACGAGCTGCCGGGGCGCATCGCGGTGCAGGACGACCTGGACAACACCGAGCTGCCCTTCTTCACCCTGGAGATGTCT
GGCACAGCAGCGGACATCTCGCTGGTGCACTGGAGACAGCAGTGGCTGGAGAATGGCACCTTGTACTTCCACGTCTCCATGAGCAGCTCC
GGGCAGCTGGCCCAAGCCACCGCCCCCACTCTCCAGGAGCCCTCGGAGATTGTTGAGGAGCAGATGCACATCCTCCACATTTCTGTGATG
GGTGGCCTCATCGCGCTGCTGCTGCTGCTGCTGGTGTTCACCGTGGCGCTGTACGCCCAGCGACGTTGGCAGAAGCGTCGCCGCATCCCC
CAGAAGAGCGCAAGCACAGAAGCCACTCATGAGATCCACTACATCCCATCTGTGCTGCTGGGTCCCCAGGCGCGGGAGAGCTTCCGTTCA
TCCCGGCTGCAAACCCACAATTCCGTCATTGGCGTGCCCATCCGGGAGACTCCCATCCTGGATGACTATGACTGTGAGGAGGATGAGGAG
CCACCTAGGCGGGCCAACCATGTCTCCCGCGAGGACGAGTTTGGCAGCCAGGTGACCCACACTCTGGACAGTCTGGGACATCCAGGGGAA
GAGAAGGTGGACTTTGAGAAGAAAGCAGCAGCTGAGGCGACTCAGGAGACAGTGGAGTCCCTGATGCAGAAGTTCAAGGAGAGTTTCCGC
GCTAACACGCCCATCGAGATCGGTCAGCTGCAACCACCCCTGCGCAGCACATCGGCAGGGAAGAGGAAGCGGAGGAGCAAGTCTCGAGGA
GGAATCAGCTTTGGGAGAGCCAAGGGGACGTCGGGCTCAGAGGCAGACGATGAAACTCAGCTGACATTCTACACGGAGCAGTACCGCAGT
CGCCGCCGCAGCAAAGGAGCAGCTGCATTGGCATGGAAGAATCCTATTTCAAGCTGGTTTACTGCTATGCTCCACTGTTTTGGTGGAGGA
ATTTTATCCTGTCTACTGCTTGCAGAGCCTCCATTGAAGTTTCTTGCAAACCACACTAACATATTACTGGCATCTTCAATCTGGTATATT
ACATTTTTTTGCCCGCATGACCTAGTTTCCCAGGGCTATTCATATCTACCTGTTCAACTACTGGCTTCGGGAATGAAGGAAGTGACCAGA
ACTTGGAAAATAGTAGGTGGAGTCACACATGCTAATAGCTATTACAAAAATGGCTGGATAGTCATGATAGCTATTGGATGGGCCCGAGGT
GCAGGTGGTACCATTATAACGAATTTTGAGAGGTTGGTAAAAGGAGATTGGAAACCAGAAGGTGATGAATGGCTGAAGATGTCATACCCT
GCCAAGGTAACCCTGCTGGGGTCAGTTATCTTCACATTCCAGCACACCCAGCATCTGGCAATATCAAAGCATAATCTTATGTTCCTTTAT
ACCATCTTTATTGTGGCCACAAAGATAACCATGATGACTACACAGACTTCTACTATGACATTTGCTCCTTTTGAGGATACATTGAGTTGG
ATGCTATTTGGCTGGCAGCAGCCGTTTTCATCATGTGAGAAGAAAAGTGAAGCAAAGTCACCTTCCAATGGCGTTGGGTCATTGGCCTCA
AAGCCGGTAGATGTTGCCTCAGATAATGTTAAAAAGAAACATACTAAGAAGAATGAATAAATTTACGTGATGAGCTCTACAAGGCCAAAA
ATTTTTTTTCTTATCTACCTGTTATATTGTGCTAATTTTTCTATGTATGTGATGTGAAATGAAGACTATATATATGGAATGGAGGTGACA
GAAAGAAAGAAATTCTTTGTTTGAGGGAGACTTCCCCTTTCTGGATTGTATTTGTAGAGTGTTACGAGTGTATCATGTGATTATGCTTTA
CCGGTATAAGAGATTCTGTTGTGATTATTTGAATAGTTTTATATTAATAAAAGAAGACAAAATTTTTTAAATGTTAGAAAAAGCAGATCT
GTCATTGCAAAGTAACAAAAATTTTAAGCTTTTAAAAATGTAGATTTTTCATATTTTTAAAATTTGAATCTATTTGAGCTTTAGTTCAGC
AGAATTAAATTTTTACTTGACATTATCATTAAAATTGCTAGGTATGGAGAACAATTCCTATTTTATTTTGAACACTGAGAAGAGTAAACT
TTTCCTAAAACACTTTATATTATAAATGAAAATAAATTGCTAGTTTATATTTTAGATATAAACATCATATTTTTTATTAATACCTACATC
AAATGGAAAATATCTGAAATTTTTTTTCCATAGCAGGTATTTTCTACTAGAAGTAGTTTTACTACTTTTCATTTAGAACAGAGTATGAGT
CTTAATCTGAAGTCTTTTTCATGCCCTTGTTTTAAAAAAACTACTTTTTTTGGCCTCAAAAAAATCAAGGGTGTAATTTTTAATAAATTG
TTAATCCTATGTTTTGTAATTTTCATTTTAGGAGCTTGACTTATTTTTTTCTCTCTCATAAAAACACATTTGTTTTAATTGTAGGAGAAA
TTTTCTCAGCATTTTGCATGTTCTTTCTAATCTTTGTTGGTCTGAATATATTGGTAGTAATTACTGTAATTATTCAACAAAAAGCATATC
CGTTCAAAAATTTTTCCACTATGTCTTTTTTCTAGTGGCTACTGTTTTAGTTTTCTAGTTGAATATCTCTGACAAGCTTTCGTATGGTTT
TGTTATATTTTCATCTACATGTAATGTGTTATTAATTTTATTAAATGAAAACTAATCACCTTCATGTGGAAATGCTCTGAGAATTGTCCT
TAGGCATTTGGTAGTAACCAGCTAACCAAGAAGAAACAGAGAAACCAGAACTTCATATGGCAGTCCATTTAGATGAAGAATGATGATATA
AAATCTGGTTCCTTCTTAGCAAAATAAAAAACAAACAAGAAAAGATACTAAATGATGTTAATTTTCTTACTTTATGATTTAGAAGTCCAG
TTATAATATTAAAACTCTGTGACATAGTTTCTTTTACCAAAACCATGAACCTACTCCCCGTATCAGGTATTTTCGATGGTTTAGAAGTAC
TCAAGTCACATCACATTCAAGTTAGAAGTTTTTTTTTTGTTGTTGTTATTTTAAATTTTTAACAAATATAAACACCAGCAGATACTATTA
CTTGCTTAAAAAATTGGGAGGGGGCACTTTTCATAGTCTTGGAATGCTAAGAAGTTTTATTTTTAATATTGTGACAGAAAGCTTTAAGTA
TTTAAGAGCTCTGTATTATATTTGATACTCTTACAGTTAAAAACTTTTCAAAATTAATACATTGTTAATTATTGACCAGTTTTGAAGTTT
GGGTTTAACTGTAGTTGAAATGGAAGGACTCTTGTTTTACACTTGTATTAAAGATAAATTTATTAAAATAAGTTATTTAGCACCAATGGA
GTATTACATTATTTTTATGTTTTATATTTTTCTTGAGGTAGAGTTTCAGAACTCATCTAGTATTTTGACTAATATAGTATATATTCAGTG
ATTACTGTTCAAATGGGACATTGGTAGAAACTTTATTAATCTATGCAAGTATCCTATAACCCTCAATTCAAGGCTCTTTTGTAAAAAATG
TACTGGAGAACATGGCTTAGGCCTGAAACCCATCCTGAATCTATTCAGGTCACCTGTAGAGTCTTGACTTGGATTTGCAAAGCAGATTGT
TAGACTCCTTACCCAATGTGAAGTGTGAATAAGGCCTATAGGCCTGCCTCACACAGCTAATCAGAGGTGGCACTGAGAAAGTCAAGTCCT
AATAGGTCTCCTTAAAAAAAAAAAGGAGACAAAAAGCTGGCAAGAACATGAGCCAGCTTCCCTCAGTGCTGTCACTCTCAAGTAAAACAT
GGCCAAATGAATATCAAACTGGTTTATCAGATTAGTCACTCTTCCTTACTGAGGGAGTATCAAGTAAGGGCTGGAGAGAGACCAGATATG
TGGAGTTGTTGGCTTTCAGTGGAAATGGTAGCCTCCCTGTGGGTAGAGACCAAAAGGTAGAGAGATGACAGAAGGGAGACTCTGATTAGT
GTATTTTTTTTTTGTCTATTCCTTAAAGCCCAGACACCTTTCCATTAAAATCTACTTCAAATCACAAGTTGATTACAATTGAGTGGAACA

>7279_7279_3_ASTN2-TMEM38B_ASTN2_chr9_119858323_ENST00000373996_TMEM38B_chr9_108467878_ENST00000374692_length(amino acids)=679AA_BP=425
MAAAGARLSPGPGSGLRGRPRLCFHPGPPPLLPLLLLFLLLLPPPPLLAGATAAASREPDSPCRLKTVTVSTLPALRESDIGWSGARAGA
GAGTGAGAAAAAASPGSPGSAGTAAESRLLLFVRNELPGRIAVQDDLDNTELPFFTLEMSGTAADISLVHWRQQWLENGTLYFHVSMSSS
GQLAQATAPTLQEPSEIVEEQMHILHISVMGGLIALLLLLLVFTVALYAQRRWQKRRRIPQKSASTEATHEIHYIPSVLLGPQARESFRS
SRLQTHNSVIGVPIRETPILDDYDCEEDEEPPRRANHVSREDEFGSQVTHTLDSLGHPGEEKVDFEKKAAAEATQETVESLMQKFKESFR
ANTPIEIGQLQPPLRSTSAGKRKRRSKSRGGISFGRAKGTSGSEADDETQLTFYTEQYRSRRRSKGAAALAWKNPISSWFTAMLHCFGGG
ILSCLLLAEPPLKFLANHTNILLASSIWYITFFCPHDLVSQGYSYLPVQLLASGMKEVTRTWKIVGGVTHANSYYKNGWIVMIAIGWARG
AGGTIITNFERLVKGDWKPEGDEWLKMSYPAKVTLLGSVIFTFQHTQHLAISKHNLMFLYTIFIVATKITMMTTQTSTMTFAPFEDTLSW

--------------------------------------------------------------

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Fusion Gene PPI Analysis for ASTN2-TMEM38B


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ASTN2-TMEM38B


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ASTN2-TMEM38B


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneASTN2C0036341Schizophrenia2PSYGENET
HgeneASTN2C0004352Autistic Disorder1CTD_human
HgeneASTN2C0005586Bipolar Disorder1PSYGENET
HgeneASTN2C0029410Osteoarthritis of hip1CTD_human
HgeneASTN2C0236733Amphetamine-Related Disorders1CTD_human
HgeneASTN2C0236804Amphetamine Addiction1CTD_human
HgeneASTN2C0236807Amphetamine Abuse1CTD_human
HgeneASTN2C0338480Common Migraine1CTD_human
TgeneC0268363Osteogenesis imperfecta type IV (disorder)2ORPHANET
TgeneC0019193Hepatitis, Toxic1CTD_human
TgeneC0029434Osteogenesis Imperfecta1GENOMICS_ENGLAND
TgeneC0860207Drug-Induced Liver Disease1CTD_human
TgeneC1262760Hepatitis, Drug-Induced1CTD_human
TgeneC3554428OSTEOGENESIS IMPERFECTA, TYPE XIV1CTD_human;GENOMICS_ENGLAND
TgeneC3658290Drug-Induced Acute Liver Injury1CTD_human
TgeneC4277682Chemical and Drug Induced Liver Injury1CTD_human
TgeneC4279912Chemically-Induced Liver Toxicity1CTD_human