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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:SOGA2-DLGAP1 (FusionGDB2 ID:HG23255TG9229)

Fusion Gene Summary for SOGA2-DLGAP1

check button Fusion gene summary
Fusion gene informationFusion gene name: SOGA2-DLGAP1
Fusion gene ID: hg23255tg9229
HgeneTgene
Gene symbol

SOGA2

DLGAP1

Gene ID

23255

9229

Gene namemicrotubule crosslinking factor 1DLG associated protein 1
SynonymsCCDC165|KIAA0802|SOGA2DAP-1|DAP-1-ALPHA|DAP-1-BETA|DAP1|DLGAP1A|DLGAP1B|GKAP|SAPAP1
Cytomap('CCDC165','MTCL1','SOGA2')('DLGAP1','DLGAP1','DLGAP1')

18p11.22

18p11.31

Type of geneprotein-codingprotein-coding
Descriptionmicrotubule cross-linking factor 1PAR-1-interacting proteinSOGA family member 2coiled-coil domain containing 165coiled-coil domain-containing protein 165disks large-associated protein 1PSD-95/SAP90 binding protein 1SAP90/PSD-95-associated protein 1discs large homolog associated protein 1guanylate kinase-associated protein
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000306329, ENST00000359865, 
ENST00000400050, ENST00000517570, 
ENST00000306285, ENST00000518815, 
ENST00000581670, 
Fusion gene scores* DoF score5 X 3 X 4=6031 X 20 X 8=4960
# samples 532
** MAII scorelog2(5/60*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(32/4960*10)=-3.95419631038688
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SOGA2 [Title/Abstract] AND DLGAP1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCCDC165(8720494)-DLGAP1(3742512), # samples:1
MTCL1(8720494)-DLGAP1(3742512), # samples:1
SOGA2(8720494)-DLGAP1(3742512), # samples:1
Anticipated loss of major functional domain due to fusion event.SOGA2-DLGAP1 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID


check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-BH-A0H9-01ACCDC165chr18

8720494

-DLGAP1chr18

3742512

-
ChimerDB4BRCATCGA-BH-A0H9-01AMTCL1chr18

8720494

+DLGAP1chr18

3742512

-
ChimerDB4BRCATCGA-BH-A0H9SOGA2chr18

8720494

+DLGAP1chr18

3742512

-


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Fusion Gene ORF analysis for SOGA2-DLGAP1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000306329ENST00000478161SOGA2chr18

8720494

+DLGAP1chr18

3742512

-
5CDS-5UTRENST00000359865ENST00000478161SOGA2chr18

8720494

+DLGAP1chr18

3742512

-
5CDS-5UTRENST00000400050ENST00000478161SOGA2chr18

8720494

+DLGAP1chr18

3742512

-
5CDS-5UTRENST00000517570ENST00000478161SOGA2chr18

8720494

+DLGAP1chr18

3742512

-
5UTR-3CDSENST00000306285ENST00000315677SOGA2chr18

8720494

+DLGAP1chr18

3742512

-
5UTR-3CDSENST00000306285ENST00000400145SOGA2chr18

8720494

+DLGAP1chr18

3742512

-
5UTR-3CDSENST00000306285ENST00000400147SOGA2chr18

8720494

+DLGAP1chr18

3742512

-
5UTR-3CDSENST00000306285ENST00000400149SOGA2chr18

8720494

+DLGAP1chr18

3742512

-
5UTR-3CDSENST00000306285ENST00000400150SOGA2chr18

8720494

+DLGAP1chr18

3742512

-
5UTR-3CDSENST00000306285ENST00000400155SOGA2chr18

8720494

+DLGAP1chr18

3742512

-
5UTR-3CDSENST00000306285ENST00000515196SOGA2chr18

8720494

+DLGAP1chr18

3742512

-
5UTR-3CDSENST00000306285ENST00000534970SOGA2chr18

8720494

+DLGAP1chr18

3742512

-
5UTR-3CDSENST00000306285ENST00000539435SOGA2chr18

8720494

+DLGAP1chr18

3742512

-
5UTR-3CDSENST00000306285ENST00000581527SOGA2chr18

8720494

+DLGAP1chr18

3742512

-
5UTR-3CDSENST00000306285ENST00000581699SOGA2chr18

8720494

+DLGAP1chr18

3742512

-
5UTR-3CDSENST00000306285ENST00000584874SOGA2chr18

8720494

+DLGAP1chr18

3742512

-
5UTR-5UTRENST00000306285ENST00000478161SOGA2chr18

8720494

+DLGAP1chr18

3742512

-
Frame-shiftENST00000306329ENST00000315677SOGA2chr18

8720494

+DLGAP1chr18

3742512

-
Frame-shiftENST00000306329ENST00000400145SOGA2chr18

8720494

+DLGAP1chr18

3742512

-
Frame-shiftENST00000306329ENST00000400147SOGA2chr18

8720494

+DLGAP1chr18

3742512

-
Frame-shiftENST00000306329ENST00000400149SOGA2chr18

8720494

+DLGAP1chr18

3742512

-
Frame-shiftENST00000306329ENST00000400150SOGA2chr18

8720494

+DLGAP1chr18

3742512

-
Frame-shiftENST00000306329ENST00000400155SOGA2chr18

8720494

+DLGAP1chr18

3742512

-
Frame-shiftENST00000306329ENST00000515196SOGA2chr18

8720494

+DLGAP1chr18

3742512

-
Frame-shiftENST00000306329ENST00000534970SOGA2chr18

8720494

+DLGAP1chr18

3742512

-
Frame-shiftENST00000306329ENST00000539435SOGA2chr18

8720494

+DLGAP1chr18

3742512

-
Frame-shiftENST00000306329ENST00000581527SOGA2chr18

8720494

+DLGAP1chr18

3742512

-
Frame-shiftENST00000306329ENST00000581699SOGA2chr18

8720494

+DLGAP1chr18

3742512

-
Frame-shiftENST00000306329ENST00000584874SOGA2chr18

8720494

+DLGAP1chr18

3742512

-
Frame-shiftENST00000359865ENST00000315677SOGA2chr18

8720494

+DLGAP1chr18

3742512

-
Frame-shiftENST00000359865ENST00000400145SOGA2chr18

8720494

+DLGAP1chr18

3742512

-
Frame-shiftENST00000359865ENST00000400147SOGA2chr18

8720494

+DLGAP1chr18

3742512

-
Frame-shiftENST00000359865ENST00000400149SOGA2chr18

8720494

+DLGAP1chr18

3742512

-
Frame-shiftENST00000359865ENST00000400150SOGA2chr18

8720494

+DLGAP1chr18

3742512

-
Frame-shiftENST00000359865ENST00000400155SOGA2chr18

8720494

+DLGAP1chr18

3742512

-
Frame-shiftENST00000359865ENST00000515196SOGA2chr18

8720494

+DLGAP1chr18

3742512

-
Frame-shiftENST00000359865ENST00000534970SOGA2chr18

8720494

+DLGAP1chr18

3742512

-
Frame-shiftENST00000359865ENST00000539435SOGA2chr18

8720494

+DLGAP1chr18

3742512

-
Frame-shiftENST00000359865ENST00000581527SOGA2chr18

8720494

+DLGAP1chr18

3742512

-
Frame-shiftENST00000359865ENST00000581699SOGA2chr18

8720494

+DLGAP1chr18

3742512

-
Frame-shiftENST00000359865ENST00000584874SOGA2chr18

8720494

+DLGAP1chr18

3742512

-
Frame-shiftENST00000400050ENST00000315677SOGA2chr18

8720494

+DLGAP1chr18

3742512

-
Frame-shiftENST00000400050ENST00000400145SOGA2chr18

8720494

+DLGAP1chr18

3742512

-
Frame-shiftENST00000400050ENST00000400147SOGA2chr18

8720494

+DLGAP1chr18

3742512

-
Frame-shiftENST00000400050ENST00000400149SOGA2chr18

8720494

+DLGAP1chr18

3742512

-
Frame-shiftENST00000400050ENST00000400150SOGA2chr18

8720494

+DLGAP1chr18

3742512

-
Frame-shiftENST00000400050ENST00000400155SOGA2chr18

8720494

+DLGAP1chr18

3742512

-
Frame-shiftENST00000400050ENST00000515196SOGA2chr18

8720494

+DLGAP1chr18

3742512

-
Frame-shiftENST00000400050ENST00000534970SOGA2chr18

8720494

+DLGAP1chr18

3742512

-
Frame-shiftENST00000400050ENST00000539435SOGA2chr18

8720494

+DLGAP1chr18

3742512

-
Frame-shiftENST00000400050ENST00000581527SOGA2chr18

8720494

+DLGAP1chr18

3742512

-
Frame-shiftENST00000400050ENST00000581699SOGA2chr18

8720494

+DLGAP1chr18

3742512

-
Frame-shiftENST00000400050ENST00000584874SOGA2chr18

8720494

+DLGAP1chr18

3742512

-
Frame-shiftENST00000517570ENST00000315677SOGA2chr18

8720494

+DLGAP1chr18

3742512

-
Frame-shiftENST00000517570ENST00000400145SOGA2chr18

8720494

+DLGAP1chr18

3742512

-
Frame-shiftENST00000517570ENST00000400147SOGA2chr18

8720494

+DLGAP1chr18

3742512

-
Frame-shiftENST00000517570ENST00000400149SOGA2chr18

8720494

+DLGAP1chr18

3742512

-
Frame-shiftENST00000517570ENST00000400150SOGA2chr18

8720494

+DLGAP1chr18

3742512

-
Frame-shiftENST00000517570ENST00000400155SOGA2chr18

8720494

+DLGAP1chr18

3742512

-
Frame-shiftENST00000517570ENST00000515196SOGA2chr18

8720494

+DLGAP1chr18

3742512

-
Frame-shiftENST00000517570ENST00000534970SOGA2chr18

8720494

+DLGAP1chr18

3742512

-
Frame-shiftENST00000517570ENST00000539435SOGA2chr18

8720494

+DLGAP1chr18

3742512

-
Frame-shiftENST00000517570ENST00000581527SOGA2chr18

8720494

+DLGAP1chr18

3742512

-
Frame-shiftENST00000517570ENST00000581699SOGA2chr18

8720494

+DLGAP1chr18

3742512

-
Frame-shiftENST00000517570ENST00000584874SOGA2chr18

8720494

+DLGAP1chr18

3742512

-
intron-3CDSENST00000518815ENST00000315677SOGA2chr18

8720494

+DLGAP1chr18

3742512

-
intron-3CDSENST00000518815ENST00000400145SOGA2chr18

8720494

+DLGAP1chr18

3742512

-
intron-3CDSENST00000518815ENST00000400147SOGA2chr18

8720494

+DLGAP1chr18

3742512

-
intron-3CDSENST00000518815ENST00000400149SOGA2chr18

8720494

+DLGAP1chr18

3742512

-
intron-3CDSENST00000518815ENST00000400150SOGA2chr18

8720494

+DLGAP1chr18

3742512

-
intron-3CDSENST00000518815ENST00000400155SOGA2chr18

8720494

+DLGAP1chr18

3742512

-
intron-3CDSENST00000518815ENST00000515196SOGA2chr18

8720494

+DLGAP1chr18

3742512

-
intron-3CDSENST00000518815ENST00000534970SOGA2chr18

8720494

+DLGAP1chr18

3742512

-
intron-3CDSENST00000518815ENST00000539435SOGA2chr18

8720494

+DLGAP1chr18

3742512

-
intron-3CDSENST00000518815ENST00000581527SOGA2chr18

8720494

+DLGAP1chr18

3742512

-
intron-3CDSENST00000518815ENST00000581699SOGA2chr18

8720494

+DLGAP1chr18

3742512

-
intron-3CDSENST00000518815ENST00000584874SOGA2chr18

8720494

+DLGAP1chr18

3742512

-
intron-3CDSENST00000581670ENST00000315677SOGA2chr18

8720494

+DLGAP1chr18

3742512

-
intron-3CDSENST00000581670ENST00000400145SOGA2chr18

8720494

+DLGAP1chr18

3742512

-
intron-3CDSENST00000581670ENST00000400147SOGA2chr18

8720494

+DLGAP1chr18

3742512

-
intron-3CDSENST00000581670ENST00000400149SOGA2chr18

8720494

+DLGAP1chr18

3742512

-
intron-3CDSENST00000581670ENST00000400150SOGA2chr18

8720494

+DLGAP1chr18

3742512

-
intron-3CDSENST00000581670ENST00000400155SOGA2chr18

8720494

+DLGAP1chr18

3742512

-
intron-3CDSENST00000581670ENST00000515196SOGA2chr18

8720494

+DLGAP1chr18

3742512

-
intron-3CDSENST00000581670ENST00000534970SOGA2chr18

8720494

+DLGAP1chr18

3742512

-
intron-3CDSENST00000581670ENST00000539435SOGA2chr18

8720494

+DLGAP1chr18

3742512

-
intron-3CDSENST00000581670ENST00000581527SOGA2chr18

8720494

+DLGAP1chr18

3742512

-
intron-3CDSENST00000581670ENST00000581699SOGA2chr18

8720494

+DLGAP1chr18

3742512

-
intron-3CDSENST00000581670ENST00000584874SOGA2chr18

8720494

+DLGAP1chr18

3742512

-
intron-5UTRENST00000518815ENST00000478161SOGA2chr18

8720494

+DLGAP1chr18

3742512

-
intron-5UTRENST00000581670ENST00000478161SOGA2chr18

8720494

+DLGAP1chr18

3742512

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for SOGA2-DLGAP1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)


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Fusion Protein Features for SOGA2-DLGAP1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:8720494/:3742512)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for SOGA2-DLGAP1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for SOGA2-DLGAP1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for SOGA2-DLGAP1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for SOGA2-DLGAP1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneMTCL1C0024117Chronic Obstructive Airway Disease1CTD_human
HgeneMTCL1C1527303Chronic Airflow Obstruction1CTD_human
TgeneC0036341Schizophrenia3PSYGENET
TgeneC1535926Neurodevelopmental Disorders1CTD_human