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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:CAMTA1-DHRS3 (FusionGDB2 ID:HG23261TG9249)

Fusion Gene Summary for CAMTA1-DHRS3

check button Fusion gene summary
Fusion gene informationFusion gene name: CAMTA1-DHRS3
Fusion gene ID: hg23261tg9249
HgeneTgene
Gene symbol

CAMTA1

DHRS3

Gene ID

23261

9249

Gene namecalmodulin binding transcription activator 1dehydrogenase/reductase 3
SynonymsCANPMRDD83.1|RDH17|Rsdr1|SDR1|SDR16C1|retSDR1
Cytomap('CAMTA1')('DHRS3')

1p36.31-p36.23

1p36.21

Type of geneprotein-codingprotein-coding
Descriptioncalmodulin-binding transcription activator 1short-chain dehydrogenase/reductase 3dehydrogenase/reductase (SDR family) member 3dehydrogenase/reductase member 3retinal short-chain dehydrogenase/reductase 1retinol dehydrogenase 17short chain dehydrogenase/reductase family 16C member 1short-chain
Modification date2020031520200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000476163, ENST00000303635, 
ENST00000439411, ENST00000467404, 
ENST00000473578, ENST00000557126, 
ENST00000476864, 
Fusion gene scores* DoF score8 X 8 X 4=2565 X 3 X 4=60
# samples 85
** MAII scorelog2(8/256*10)=-1.67807190511264
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(5/60*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CAMTA1 [Title/Abstract] AND DHRS3 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCAMTA1(6845635)-DHRS3(12640694), # samples:4
Anticipated loss of major functional domain due to fusion event.CAMTA1-DHRS3 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
CAMTA1-DHRS3 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across CAMTA1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across DHRS3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUSCTCGA-46-3769-01ACAMTA1chr1

6845635

-DHRS3chr1

12640694

-
ChimerDB4LUSCTCGA-46-3769-01ACAMTA1chr1

6845635

+DHRS3chr1

12640694

-
ChimerDB4LUSCTCGA-46-3769CAMTA1chr1

6845635

+DHRS3chr1

12640694

-


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Fusion Gene ORF analysis for CAMTA1-DHRS3

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000476163ENST00000376223CAMTA1chr1

6845635

+DHRS3chr1

12640694

-
3UTR-5UTRENST00000476163ENST00000482265CAMTA1chr1

6845635

+DHRS3chr1

12640694

-
5CDS-5UTRENST00000303635ENST00000482265CAMTA1chr1

6845635

+DHRS3chr1

12640694

-
5CDS-5UTRENST00000439411ENST00000482265CAMTA1chr1

6845635

+DHRS3chr1

12640694

-
5CDS-5UTRENST00000467404ENST00000482265CAMTA1chr1

6845635

+DHRS3chr1

12640694

-
5CDS-5UTRENST00000473578ENST00000482265CAMTA1chr1

6845635

+DHRS3chr1

12640694

-
5CDS-5UTRENST00000557126ENST00000482265CAMTA1chr1

6845635

+DHRS3chr1

12640694

-
In-frameENST00000303635ENST00000376223CAMTA1chr1

6845635

+DHRS3chr1

12640694

-
In-frameENST00000439411ENST00000376223CAMTA1chr1

6845635

+DHRS3chr1

12640694

-
In-frameENST00000467404ENST00000376223CAMTA1chr1

6845635

+DHRS3chr1

12640694

-
In-frameENST00000473578ENST00000376223CAMTA1chr1

6845635

+DHRS3chr1

12640694

-
In-frameENST00000557126ENST00000376223CAMTA1chr1

6845635

+DHRS3chr1

12640694

-
intron-3CDSENST00000476864ENST00000376223CAMTA1chr1

6845635

+DHRS3chr1

12640694

-
intron-5UTRENST00000476864ENST00000482265CAMTA1chr1

6845635

+DHRS3chr1

12640694

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000303635CAMTA1chr16845635+ENST00000376223DHRS3chr112640694-1396252207965252
ENST00000439411CAMTA1chr16845635+ENST00000376223DHRS3chr112640694-1189450758252
ENST00000557126CAMTA1chr16845635+ENST00000376223DHRS3chr112640694-12298540798252
ENST00000473578CAMTA1chr16845635+ENST00000376223DHRS3chr112640694-12409651809252
ENST00000467404CAMTA1chr16845635+ENST00000376223DHRS3chr112640694-12025813771252

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000303635ENST00000376223CAMTA1chr16845635+DHRS3chr112640694-0.0138386170.98616135
ENST00000439411ENST00000376223CAMTA1chr16845635+DHRS3chr112640694-0.0060011610.9939989
ENST00000557126ENST00000376223CAMTA1chr16845635+DHRS3chr112640694-0.0075396410.9924603
ENST00000473578ENST00000376223CAMTA1chr16845635+DHRS3chr112640694-0.0079580420.992042
ENST00000467404ENST00000376223CAMTA1chr16845635+DHRS3chr112640694-0.0062886840.99371135

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Fusion Genomic Features for CAMTA1-DHRS3


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for CAMTA1-DHRS3


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:6845635/chr1:12640694)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneDHRS3chr1:6845635chr1:12640694ENST0000037622306170_19065303.0TransmembraneHelical
TgeneDHRS3chr1:6845635chr1:12640694ENST0000037622306195_21565303.0TransmembraneHelical
TgeneDHRS3chr1:6845635chr1:12640694ENST0000037622306253_27365303.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCAMTA1chr1:6845635chr1:12640694ENST00000303635+1231038_1041151674.0Compositional biasNote=Poly-Val
HgeneCAMTA1chr1:6845635chr1:12640694ENST00000303635+123499_502151674.0Compositional biasNote=Poly-Gly
HgeneCAMTA1chr1:6845635chr1:12640694ENST00000439411+1221038_1041151660.0Compositional biasNote=Poly-Val
HgeneCAMTA1chr1:6845635chr1:12640694ENST00000439411+122499_502151660.0Compositional biasNote=Poly-Gly
HgeneCAMTA1chr1:6845635chr1:12640694ENST00000473578+141038_10411581.0Compositional biasNote=Poly-Val
HgeneCAMTA1chr1:6845635chr1:12640694ENST00000473578+14499_5021581.0Compositional biasNote=Poly-Gly
HgeneCAMTA1chr1:6845635chr1:12640694ENST00000476864+161038_10410238.0Compositional biasNote=Poly-Val
HgeneCAMTA1chr1:6845635chr1:12640694ENST00000476864+16499_5020238.0Compositional biasNote=Poly-Gly
HgeneCAMTA1chr1:6845635chr1:12640694ENST00000557126+141038_104115102.0Compositional biasNote=Poly-Val
HgeneCAMTA1chr1:6845635chr1:12640694ENST00000557126+14499_50215102.0Compositional biasNote=Poly-Gly
HgeneCAMTA1chr1:6845635chr1:12640694ENST00000303635+12363_188151674.0DNA bindingCG-1
HgeneCAMTA1chr1:6845635chr1:12640694ENST00000439411+12263_188151660.0DNA bindingCG-1
HgeneCAMTA1chr1:6845635chr1:12640694ENST00000473578+1463_1881581.0DNA bindingCG-1
HgeneCAMTA1chr1:6845635chr1:12640694ENST00000476864+1663_1880238.0DNA bindingCG-1
HgeneCAMTA1chr1:6845635chr1:12640694ENST00000557126+1463_18815102.0DNA bindingCG-1
HgeneCAMTA1chr1:6845635chr1:12640694ENST00000303635+1231547_1576151674.0DomainIQ 1
HgeneCAMTA1chr1:6845635chr1:12640694ENST00000303635+1231577_1599151674.0DomainIQ 2
HgeneCAMTA1chr1:6845635chr1:12640694ENST00000303635+1231600_1622151674.0DomainIQ 3
HgeneCAMTA1chr1:6845635chr1:12640694ENST00000303635+123873_953151674.0DomainNote=IPT/TIG
HgeneCAMTA1chr1:6845635chr1:12640694ENST00000439411+1221547_1576151660.0DomainIQ 1
HgeneCAMTA1chr1:6845635chr1:12640694ENST00000439411+1221577_1599151660.0DomainIQ 2
HgeneCAMTA1chr1:6845635chr1:12640694ENST00000439411+1221600_1622151660.0DomainIQ 3
HgeneCAMTA1chr1:6845635chr1:12640694ENST00000439411+122873_953151660.0DomainNote=IPT/TIG
HgeneCAMTA1chr1:6845635chr1:12640694ENST00000473578+141547_15761581.0DomainIQ 1
HgeneCAMTA1chr1:6845635chr1:12640694ENST00000473578+141577_15991581.0DomainIQ 2
HgeneCAMTA1chr1:6845635chr1:12640694ENST00000473578+141600_16221581.0DomainIQ 3
HgeneCAMTA1chr1:6845635chr1:12640694ENST00000473578+14873_9531581.0DomainNote=IPT/TIG
HgeneCAMTA1chr1:6845635chr1:12640694ENST00000476864+161547_15760238.0DomainIQ 1
HgeneCAMTA1chr1:6845635chr1:12640694ENST00000476864+161577_15990238.0DomainIQ 2
HgeneCAMTA1chr1:6845635chr1:12640694ENST00000476864+161600_16220238.0DomainIQ 3
HgeneCAMTA1chr1:6845635chr1:12640694ENST00000476864+16873_9530238.0DomainNote=IPT/TIG
HgeneCAMTA1chr1:6845635chr1:12640694ENST00000557126+141547_157615102.0DomainIQ 1
HgeneCAMTA1chr1:6845635chr1:12640694ENST00000557126+141577_159915102.0DomainIQ 2
HgeneCAMTA1chr1:6845635chr1:12640694ENST00000557126+141600_162215102.0DomainIQ 3
HgeneCAMTA1chr1:6845635chr1:12640694ENST00000557126+14873_95315102.0DomainNote=IPT/TIG
HgeneCAMTA1chr1:6845635chr1:12640694ENST00000303635+123112_119151674.0MotifNuclear localization signal
HgeneCAMTA1chr1:6845635chr1:12640694ENST00000439411+122112_119151660.0MotifNuclear localization signal
HgeneCAMTA1chr1:6845635chr1:12640694ENST00000473578+14112_1191581.0MotifNuclear localization signal
HgeneCAMTA1chr1:6845635chr1:12640694ENST00000476864+16112_1190238.0MotifNuclear localization signal
HgeneCAMTA1chr1:6845635chr1:12640694ENST00000557126+14112_11915102.0MotifNuclear localization signal
HgeneCAMTA1chr1:6845635chr1:12640694ENST00000303635+1231064_1093151674.0RepeatNote=ANK 1
HgeneCAMTA1chr1:6845635chr1:12640694ENST00000303635+1231109_1129151674.0RepeatNote=ANK 2
HgeneCAMTA1chr1:6845635chr1:12640694ENST00000303635+1231143_1172151674.0RepeatNote=ANK 3
HgeneCAMTA1chr1:6845635chr1:12640694ENST00000439411+1221064_1093151660.0RepeatNote=ANK 1
HgeneCAMTA1chr1:6845635chr1:12640694ENST00000439411+1221109_1129151660.0RepeatNote=ANK 2
HgeneCAMTA1chr1:6845635chr1:12640694ENST00000439411+1221143_1172151660.0RepeatNote=ANK 3
HgeneCAMTA1chr1:6845635chr1:12640694ENST00000473578+141064_10931581.0RepeatNote=ANK 1
HgeneCAMTA1chr1:6845635chr1:12640694ENST00000473578+141109_11291581.0RepeatNote=ANK 2
HgeneCAMTA1chr1:6845635chr1:12640694ENST00000473578+141143_11721581.0RepeatNote=ANK 3
HgeneCAMTA1chr1:6845635chr1:12640694ENST00000476864+161064_10930238.0RepeatNote=ANK 1
HgeneCAMTA1chr1:6845635chr1:12640694ENST00000476864+161109_11290238.0RepeatNote=ANK 2
HgeneCAMTA1chr1:6845635chr1:12640694ENST00000476864+161143_11720238.0RepeatNote=ANK 3
HgeneCAMTA1chr1:6845635chr1:12640694ENST00000557126+141064_109315102.0RepeatNote=ANK 1
HgeneCAMTA1chr1:6845635chr1:12640694ENST00000557126+141109_112915102.0RepeatNote=ANK 2
HgeneCAMTA1chr1:6845635chr1:12640694ENST00000557126+141143_117215102.0RepeatNote=ANK 3
TgeneDHRS3chr1:6845635chr1:12640694ENST00000376223069_2965303.0TransmembraneHelical


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Fusion Gene Sequence for CAMTA1-DHRS3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>12752_12752_1_CAMTA1-DHRS3_CAMTA1_chr1_6845635_ENST00000303635_DHRS3_chr1_12640694_ENST00000376223_length(transcript)=1396nt_BP=252nt
GACGCTCCTCCCGGAGAGTAGTGAGACCCCTGGTGCGGGGCGATTGGCGGCGGGAGCGATGAGTGGCAGCCGCACGGCCCAACGGGAGCT
GTGCGTGGGCCGCGGGGCGGGGCCAGGGCGGGTGCGCGGCGGCGGCGGGGTGGCTGGGCCGGCGGCGGCGGCGGTACGAGGCGCGCGCTC
GGGGTCCCGGTCGCGAGGAGGAGGAGGATGTGGCGCGCGGAGGGGAAATGGCTGCCGAAAACAAGCCGGAAGATTGTTCTCTGGGGCCGG
ACTGAGAAATGCCTGAAGGAGACGACGGAGGAGATCCGGCAGATGGGCACTGAGTGCCATTACTTCATCTGTGATGTGGGCAACCGGGAG
GAGGTGTACCAGACGGCCAAGGCCGTCCGGGAGAAGGTGGGTGACATCACCATCCTGGTGAACAATGCCGCCGTGGTCCATGGGAAGAGC
CTAATGGACAGTGATGATGATGCCCTCCTCAAGTCCCAACACATCAACACCCTGGGCCAGTTCTGGACCACCAAGGCCTTCCTGCCACGT
ATGCTGGAGCTGCAGAATGGCCACATCGTGTGCCTCAACTCCGTGCTGGCACTGTCTGCCATCCCCGGTGCCATCGACTACTGCACATCC
AAAGCGTCAGCCTTCGCCTTCATGGAGAGCCTGACCCTGGGGCTGCTGGACTGTCCGGGAGTCAGCGCCACCACAGTGCTGCCCTTCCAC
ACCAGCACCGAGATGTTCCAGGGCATGAGAGTCAGGTTTCCCAACCTCTTTCCCCCACTGAAGCCGGAGACGGTGGCCCGGAGGACAGTG
GAAGCTGTGCAGCTCAACCAGGCCCTCCTCCTCCTCCCATGGACAATGCATGCCCTCGTTATCTTGAAAAGCATACTTCCACAGGCTGCA
CTCGAGGAGATCCACAAATTCTCAGGAACCTACACCTGCATGAACACTTTCAAAGGGCGGACATAGAGACAGGATGAAGACATGCTTGAG
GAGCCACGGAGTTTGGGGGCCACAGCACCTGGGCACACACCCGAGCACCTGTCCATTGGCATGCTTCTGCTGGGTGAGCAGGACAGCTCC
TGTCCCCAGCGAAGAATCCGGCTGCCCCTGGGCCAGTCCCAGGACCTTTGCACAGGACTGATGGGTATAACTGACCCCCACAGGGAGGCA
GGAAAACAGCCAGAAGCCACCTTGACACTTTTGAACATTTCCAGTTCTGTAGAGTTTATTGTCAATTGCTTCTCAAGTCTAACCAGCCTC
AGCAGTGTGCATAGACCATTTCCAGGAGGGTCTGTCCCCAGATGCTCTGCCTCCCGTTCCAAAACCCACTCATCCTCAGCTTGCACAAAC

>12752_12752_1_CAMTA1-DHRS3_CAMTA1_chr1_6845635_ENST00000303635_DHRS3_chr1_12640694_ENST00000376223_length(amino acids)=252AA_BP=15
MWRAEGKWLPKTSRKIVLWGRTEKCLKETTEEIRQMGTECHYFICDVGNREEVYQTAKAVREKVGDITILVNNAAVVHGKSLMDSDDDAL
LKSQHINTLGQFWTTKAFLPRMLELQNGHIVCLNSVLALSAIPGAIDYCTSKASAFAFMESLTLGLLDCPGVSATTVLPFHTSTEMFQGM

--------------------------------------------------------------
>12752_12752_2_CAMTA1-DHRS3_CAMTA1_chr1_6845635_ENST00000439411_DHRS3_chr1_12640694_ENST00000376223_length(transcript)=1189nt_BP=45nt
ATGTGGCGCGCGGAGGGGAAATGGCTGCCGAAAACAAGCCGGAAGATTGTTCTCTGGGGCCGGACTGAGAAATGCCTGAAGGAGACGACG
GAGGAGATCCGGCAGATGGGCACTGAGTGCCATTACTTCATCTGTGATGTGGGCAACCGGGAGGAGGTGTACCAGACGGCCAAGGCCGTC
CGGGAGAAGGTGGGTGACATCACCATCCTGGTGAACAATGCCGCCGTGGTCCATGGGAAGAGCCTAATGGACAGTGATGATGATGCCCTC
CTCAAGTCCCAACACATCAACACCCTGGGCCAGTTCTGGACCACCAAGGCCTTCCTGCCACGTATGCTGGAGCTGCAGAATGGCCACATC
GTGTGCCTCAACTCCGTGCTGGCACTGTCTGCCATCCCCGGTGCCATCGACTACTGCACATCCAAAGCGTCAGCCTTCGCCTTCATGGAG
AGCCTGACCCTGGGGCTGCTGGACTGTCCGGGAGTCAGCGCCACCACAGTGCTGCCCTTCCACACCAGCACCGAGATGTTCCAGGGCATG
AGAGTCAGGTTTCCCAACCTCTTTCCCCCACTGAAGCCGGAGACGGTGGCCCGGAGGACAGTGGAAGCTGTGCAGCTCAACCAGGCCCTC
CTCCTCCTCCCATGGACAATGCATGCCCTCGTTATCTTGAAAAGCATACTTCCACAGGCTGCACTCGAGGAGATCCACAAATTCTCAGGA
ACCTACACCTGCATGAACACTTTCAAAGGGCGGACATAGAGACAGGATGAAGACATGCTTGAGGAGCCACGGAGTTTGGGGGCCACAGCA
CCTGGGCACACACCCGAGCACCTGTCCATTGGCATGCTTCTGCTGGGTGAGCAGGACAGCTCCTGTCCCCAGCGAAGAATCCGGCTGCCC
CTGGGCCAGTCCCAGGACCTTTGCACAGGACTGATGGGTATAACTGACCCCCACAGGGAGGCAGGAAAACAGCCAGAAGCCACCTTGACA
CTTTTGAACATTTCCAGTTCTGTAGAGTTTATTGTCAATTGCTTCTCAAGTCTAACCAGCCTCAGCAGTGTGCATAGACCATTTCCAGGA
GGGTCTGTCCCCAGATGCTCTGCCTCCCGTTCCAAAACCCACTCATCCTCAGCTTGCACAAACTGGTTGAACGGCAGGAATGAAAAATAA

>12752_12752_2_CAMTA1-DHRS3_CAMTA1_chr1_6845635_ENST00000439411_DHRS3_chr1_12640694_ENST00000376223_length(amino acids)=252AA_BP=15
MWRAEGKWLPKTSRKIVLWGRTEKCLKETTEEIRQMGTECHYFICDVGNREEVYQTAKAVREKVGDITILVNNAAVVHGKSLMDSDDDAL
LKSQHINTLGQFWTTKAFLPRMLELQNGHIVCLNSVLALSAIPGAIDYCTSKASAFAFMESLTLGLLDCPGVSATTVLPFHTSTEMFQGM

--------------------------------------------------------------
>12752_12752_3_CAMTA1-DHRS3_CAMTA1_chr1_6845635_ENST00000467404_DHRS3_chr1_12640694_ENST00000376223_length(transcript)=1202nt_BP=58nt
GAGGAGGAGGAGGATGTGGCGCGCGGAGGGGAAATGGCTGCCGAAAACAAGCCGGAAGATTGTTCTCTGGGGCCGGACTGAGAAATGCCT
GAAGGAGACGACGGAGGAGATCCGGCAGATGGGCACTGAGTGCCATTACTTCATCTGTGATGTGGGCAACCGGGAGGAGGTGTACCAGAC
GGCCAAGGCCGTCCGGGAGAAGGTGGGTGACATCACCATCCTGGTGAACAATGCCGCCGTGGTCCATGGGAAGAGCCTAATGGACAGTGA
TGATGATGCCCTCCTCAAGTCCCAACACATCAACACCCTGGGCCAGTTCTGGACCACCAAGGCCTTCCTGCCACGTATGCTGGAGCTGCA
GAATGGCCACATCGTGTGCCTCAACTCCGTGCTGGCACTGTCTGCCATCCCCGGTGCCATCGACTACTGCACATCCAAAGCGTCAGCCTT
CGCCTTCATGGAGAGCCTGACCCTGGGGCTGCTGGACTGTCCGGGAGTCAGCGCCACCACAGTGCTGCCCTTCCACACCAGCACCGAGAT
GTTCCAGGGCATGAGAGTCAGGTTTCCCAACCTCTTTCCCCCACTGAAGCCGGAGACGGTGGCCCGGAGGACAGTGGAAGCTGTGCAGCT
CAACCAGGCCCTCCTCCTCCTCCCATGGACAATGCATGCCCTCGTTATCTTGAAAAGCATACTTCCACAGGCTGCACTCGAGGAGATCCA
CAAATTCTCAGGAACCTACACCTGCATGAACACTTTCAAAGGGCGGACATAGAGACAGGATGAAGACATGCTTGAGGAGCCACGGAGTTT
GGGGGCCACAGCACCTGGGCACACACCCGAGCACCTGTCCATTGGCATGCTTCTGCTGGGTGAGCAGGACAGCTCCTGTCCCCAGCGAAG
AATCCGGCTGCCCCTGGGCCAGTCCCAGGACCTTTGCACAGGACTGATGGGTATAACTGACCCCCACAGGGAGGCAGGAAAACAGCCAGA
AGCCACCTTGACACTTTTGAACATTTCCAGTTCTGTAGAGTTTATTGTCAATTGCTTCTCAAGTCTAACCAGCCTCAGCAGTGTGCATAG
ACCATTTCCAGGAGGGTCTGTCCCCAGATGCTCTGCCTCCCGTTCCAAAACCCACTCATCCTCAGCTTGCACAAACTGGTTGAACGGCAG

>12752_12752_3_CAMTA1-DHRS3_CAMTA1_chr1_6845635_ENST00000467404_DHRS3_chr1_12640694_ENST00000376223_length(amino acids)=252AA_BP=15
MWRAEGKWLPKTSRKIVLWGRTEKCLKETTEEIRQMGTECHYFICDVGNREEVYQTAKAVREKVGDITILVNNAAVVHGKSLMDSDDDAL
LKSQHINTLGQFWTTKAFLPRMLELQNGHIVCLNSVLALSAIPGAIDYCTSKASAFAFMESLTLGLLDCPGVSATTVLPFHTSTEMFQGM

--------------------------------------------------------------
>12752_12752_4_CAMTA1-DHRS3_CAMTA1_chr1_6845635_ENST00000473578_DHRS3_chr1_12640694_ENST00000376223_length(transcript)=1240nt_BP=96nt
GGCGGCGGTACGAGGCGCGCGCTCGGGGTCCCGGTCGCGAGGAGGAGGAGGATGTGGCGCGCGGAGGGGAAATGGCTGCCGAAAACAAGC
CGGAAGATTGTTCTCTGGGGCCGGACTGAGAAATGCCTGAAGGAGACGACGGAGGAGATCCGGCAGATGGGCACTGAGTGCCATTACTTC
ATCTGTGATGTGGGCAACCGGGAGGAGGTGTACCAGACGGCCAAGGCCGTCCGGGAGAAGGTGGGTGACATCACCATCCTGGTGAACAAT
GCCGCCGTGGTCCATGGGAAGAGCCTAATGGACAGTGATGATGATGCCCTCCTCAAGTCCCAACACATCAACACCCTGGGCCAGTTCTGG
ACCACCAAGGCCTTCCTGCCACGTATGCTGGAGCTGCAGAATGGCCACATCGTGTGCCTCAACTCCGTGCTGGCACTGTCTGCCATCCCC
GGTGCCATCGACTACTGCACATCCAAAGCGTCAGCCTTCGCCTTCATGGAGAGCCTGACCCTGGGGCTGCTGGACTGTCCGGGAGTCAGC
GCCACCACAGTGCTGCCCTTCCACACCAGCACCGAGATGTTCCAGGGCATGAGAGTCAGGTTTCCCAACCTCTTTCCCCCACTGAAGCCG
GAGACGGTGGCCCGGAGGACAGTGGAAGCTGTGCAGCTCAACCAGGCCCTCCTCCTCCTCCCATGGACAATGCATGCCCTCGTTATCTTG
AAAAGCATACTTCCACAGGCTGCACTCGAGGAGATCCACAAATTCTCAGGAACCTACACCTGCATGAACACTTTCAAAGGGCGGACATAG
AGACAGGATGAAGACATGCTTGAGGAGCCACGGAGTTTGGGGGCCACAGCACCTGGGCACACACCCGAGCACCTGTCCATTGGCATGCTT
CTGCTGGGTGAGCAGGACAGCTCCTGTCCCCAGCGAAGAATCCGGCTGCCCCTGGGCCAGTCCCAGGACCTTTGCACAGGACTGATGGGT
ATAACTGACCCCCACAGGGAGGCAGGAAAACAGCCAGAAGCCACCTTGACACTTTTGAACATTTCCAGTTCTGTAGAGTTTATTGTCAAT
TGCTTCTCAAGTCTAACCAGCCTCAGCAGTGTGCATAGACCATTTCCAGGAGGGTCTGTCCCCAGATGCTCTGCCTCCCGTTCCAAAACC

>12752_12752_4_CAMTA1-DHRS3_CAMTA1_chr1_6845635_ENST00000473578_DHRS3_chr1_12640694_ENST00000376223_length(amino acids)=252AA_BP=15
MWRAEGKWLPKTSRKIVLWGRTEKCLKETTEEIRQMGTECHYFICDVGNREEVYQTAKAVREKVGDITILVNNAAVVHGKSLMDSDDDAL
LKSQHINTLGQFWTTKAFLPRMLELQNGHIVCLNSVLALSAIPGAIDYCTSKASAFAFMESLTLGLLDCPGVSATTVLPFHTSTEMFQGM

--------------------------------------------------------------
>12752_12752_5_CAMTA1-DHRS3_CAMTA1_chr1_6845635_ENST00000557126_DHRS3_chr1_12640694_ENST00000376223_length(transcript)=1229nt_BP=85nt
GAGGCGCGCGCTCGGGGTCCCGGTCGCGAGGAGGAGGAGGATGTGGCGCGCGGAGGGGAAATGGCTGCCGAAAACAAGCCGGAAGATTGT
TCTCTGGGGCCGGACTGAGAAATGCCTGAAGGAGACGACGGAGGAGATCCGGCAGATGGGCACTGAGTGCCATTACTTCATCTGTGATGT
GGGCAACCGGGAGGAGGTGTACCAGACGGCCAAGGCCGTCCGGGAGAAGGTGGGTGACATCACCATCCTGGTGAACAATGCCGCCGTGGT
CCATGGGAAGAGCCTAATGGACAGTGATGATGATGCCCTCCTCAAGTCCCAACACATCAACACCCTGGGCCAGTTCTGGACCACCAAGGC
CTTCCTGCCACGTATGCTGGAGCTGCAGAATGGCCACATCGTGTGCCTCAACTCCGTGCTGGCACTGTCTGCCATCCCCGGTGCCATCGA
CTACTGCACATCCAAAGCGTCAGCCTTCGCCTTCATGGAGAGCCTGACCCTGGGGCTGCTGGACTGTCCGGGAGTCAGCGCCACCACAGT
GCTGCCCTTCCACACCAGCACCGAGATGTTCCAGGGCATGAGAGTCAGGTTTCCCAACCTCTTTCCCCCACTGAAGCCGGAGACGGTGGC
CCGGAGGACAGTGGAAGCTGTGCAGCTCAACCAGGCCCTCCTCCTCCTCCCATGGACAATGCATGCCCTCGTTATCTTGAAAAGCATACT
TCCACAGGCTGCACTCGAGGAGATCCACAAATTCTCAGGAACCTACACCTGCATGAACACTTTCAAAGGGCGGACATAGAGACAGGATGA
AGACATGCTTGAGGAGCCACGGAGTTTGGGGGCCACAGCACCTGGGCACACACCCGAGCACCTGTCCATTGGCATGCTTCTGCTGGGTGA
GCAGGACAGCTCCTGTCCCCAGCGAAGAATCCGGCTGCCCCTGGGCCAGTCCCAGGACCTTTGCACAGGACTGATGGGTATAACTGACCC
CCACAGGGAGGCAGGAAAACAGCCAGAAGCCACCTTGACACTTTTGAACATTTCCAGTTCTGTAGAGTTTATTGTCAATTGCTTCTCAAG
TCTAACCAGCCTCAGCAGTGTGCATAGACCATTTCCAGGAGGGTCTGTCCCCAGATGCTCTGCCTCCCGTTCCAAAACCCACTCATCCTC

>12752_12752_5_CAMTA1-DHRS3_CAMTA1_chr1_6845635_ENST00000557126_DHRS3_chr1_12640694_ENST00000376223_length(amino acids)=252AA_BP=15
MWRAEGKWLPKTSRKIVLWGRTEKCLKETTEEIRQMGTECHYFICDVGNREEVYQTAKAVREKVGDITILVNNAAVVHGKSLMDSDDDAL
LKSQHINTLGQFWTTKAFLPRMLELQNGHIVCLNSVLALSAIPGAIDYCTSKASAFAFMESLTLGLLDCPGVSATTVLPFHTSTEMFQGM

--------------------------------------------------------------

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Fusion Gene PPI Analysis for CAMTA1-DHRS3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for CAMTA1-DHRS3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for CAMTA1-DHRS3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneCAMTA1C0206732Epithelioid hemangioendothelioma1ORPHANET
HgeneCAMTA1C3553661CEREBELLAR ATAXIA, NONPROGRESSIVE, WITH MENTAL RETARDATION1CTD_human;GENOMICS_ENGLAND;ORPHANET
TgeneC0023893Liver Cirrhosis, Experimental1CTD_human