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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:FBXW11-SPIDR (FusionGDB2 ID:HG23291TG23514)

Fusion Gene Summary for FBXW11-SPIDR

check button Fusion gene summary
Fusion gene informationFusion gene name: FBXW11-SPIDR
Fusion gene ID: hg23291tg23514
HgeneTgene
Gene symbol

FBXW11

SPIDR

Gene ID

23291

23514

Gene nameF-box and WD repeat domain containing 11scaffold protein involved in DNA repair
SynonymsBTRC2|BTRCP2|FBW1B|FBXW1B|Fbw11|HosKIAA0146
Cytomap('FBXW11')('SPIDR')

5q35.1

8q11.21

Type of geneprotein-codingprotein-coding
DescriptionF-box/WD repeat-containing protein 11F-box and WD repeats protein beta-TrCP2F-box and WD-40 domain protein 11F-box and WD-40 domain protein 1BF-box protein Fbw1bF-box/WD repeat-containing protein 1Bbeta-transducin repeat-containing protein 2homologDNA repair-scaffolding proteinscaffolding protein involved in DNA repair
Modification date2020032920200320
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000265094, ENST00000296933, 
ENST00000393802, ENST00000425623, 
ENST00000522891, 
Fusion gene scores* DoF score13 X 6 X 9=70219 X 18 X 7=2394
# samples 1322
** MAII scorelog2(13/702*10)=-2.43295940727611
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(22/2394*10)=-3.44384772341884
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: FBXW11 [Title/Abstract] AND SPIDR [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointFBXW11(171337576)-SPIDR(48352885), # samples:1
Anticipated loss of major functional domain due to fusion event.FBXW11-SPIDR seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
FBXW11-SPIDR seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
FBXW11-SPIDR seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
FBXW11-SPIDR seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
FBXW11-SPIDR seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
FBXW11-SPIDR seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneFBXW11

GO:0000209

protein polyubiquitination

20347421

HgeneFBXW11

GO:0016567

protein ubiquitination

16885022

HgeneFBXW11

GO:0031146

SCF-dependent proteasomal ubiquitin-dependent protein catabolic process

20347421

HgeneFBXW11

GO:0043161

proteasome-mediated ubiquitin-dependent protein catabolic process

20347421

TgeneSPIDR

GO:0006974

cellular response to DNA damage stimulus

23509288

TgeneSPIDR

GO:0010569

regulation of double-strand break repair via homologous recombination

23754376

TgeneSPIDR

GO:0031334

positive regulation of protein complex assembly

23509288

TgeneSPIDR

GO:0070202

regulation of establishment of protein localization to chromosome

23509288

TgeneSPIDR

GO:0071479

cellular response to ionizing radiation

23509288|23754376

TgeneSPIDR

GO:0072711

cellular response to hydroxyurea

23509288

TgeneSPIDR

GO:0072757

cellular response to camptothecin

23509288


check buttonFusion gene breakpoints across FBXW11 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across SPIDR (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-BR-8078-01AFBXW11chr5

171337576

-SPIDRchr8

48352885

+


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Fusion Gene ORF analysis for FBXW11-SPIDR

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000265094ENST00000521214FBXW11chr5

171337576

-SPIDRchr8

48352885

+
5CDS-3UTRENST00000296933ENST00000521214FBXW11chr5

171337576

-SPIDRchr8

48352885

+
5CDS-3UTRENST00000393802ENST00000521214FBXW11chr5

171337576

-SPIDRchr8

48352885

+
5CDS-3UTRENST00000425623ENST00000521214FBXW11chr5

171337576

-SPIDRchr8

48352885

+
5CDS-intronENST00000265094ENST00000517693FBXW11chr5

171337576

-SPIDRchr8

48352885

+
5CDS-intronENST00000265094ENST00000518060FBXW11chr5

171337576

-SPIDRchr8

48352885

+
5CDS-intronENST00000296933ENST00000517693FBXW11chr5

171337576

-SPIDRchr8

48352885

+
5CDS-intronENST00000296933ENST00000518060FBXW11chr5

171337576

-SPIDRchr8

48352885

+
5CDS-intronENST00000393802ENST00000517693FBXW11chr5

171337576

-SPIDRchr8

48352885

+
5CDS-intronENST00000393802ENST00000518060FBXW11chr5

171337576

-SPIDRchr8

48352885

+
5CDS-intronENST00000425623ENST00000517693FBXW11chr5

171337576

-SPIDRchr8

48352885

+
5CDS-intronENST00000425623ENST00000518060FBXW11chr5

171337576

-SPIDRchr8

48352885

+
Frame-shiftENST00000265094ENST00000297423FBXW11chr5

171337576

-SPIDRchr8

48352885

+
Frame-shiftENST00000265094ENST00000518074FBXW11chr5

171337576

-SPIDRchr8

48352885

+
Frame-shiftENST00000265094ENST00000541342FBXW11chr5

171337576

-SPIDRchr8

48352885

+
Frame-shiftENST00000296933ENST00000297423FBXW11chr5

171337576

-SPIDRchr8

48352885

+
Frame-shiftENST00000296933ENST00000518074FBXW11chr5

171337576

-SPIDRchr8

48352885

+
Frame-shiftENST00000296933ENST00000541342FBXW11chr5

171337576

-SPIDRchr8

48352885

+
Frame-shiftENST00000393802ENST00000297423FBXW11chr5

171337576

-SPIDRchr8

48352885

+
Frame-shiftENST00000393802ENST00000518074FBXW11chr5

171337576

-SPIDRchr8

48352885

+
Frame-shiftENST00000393802ENST00000541342FBXW11chr5

171337576

-SPIDRchr8

48352885

+
In-frameENST00000425623ENST00000297423FBXW11chr5

171337576

-SPIDRchr8

48352885

+
In-frameENST00000425623ENST00000518074FBXW11chr5

171337576

-SPIDRchr8

48352885

+
In-frameENST00000425623ENST00000541342FBXW11chr5

171337576

-SPIDRchr8

48352885

+
intron-3CDSENST00000522891ENST00000297423FBXW11chr5

171337576

-SPIDRchr8

48352885

+
intron-3CDSENST00000522891ENST00000518074FBXW11chr5

171337576

-SPIDRchr8

48352885

+
intron-3CDSENST00000522891ENST00000541342FBXW11chr5

171337576

-SPIDRchr8

48352885

+
intron-3UTRENST00000522891ENST00000521214FBXW11chr5

171337576

-SPIDRchr8

48352885

+
intron-intronENST00000522891ENST00000517693FBXW11chr5

171337576

-SPIDRchr8

48352885

+
intron-intronENST00000522891ENST00000518060FBXW11chr5

171337576

-SPIDRchr8

48352885

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000425623FBXW11chr5171337576-ENST00000297423SPIDRchr848352885+31143871102257715
ENST00000425623FBXW11chr5171337576-ENST00000518074SPIDRchr848352885+23383871102320736
ENST00000425623FBXW11chr5171337576-ENST00000541342SPIDRchr848352885+23193871102257715

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000425623ENST00000297423FBXW11chr5171337576-SPIDRchr848352885+0.0008041420.9991959
ENST00000425623ENST00000518074FBXW11chr5171337576-SPIDRchr848352885+0.0024215130.99757856
ENST00000425623ENST00000541342FBXW11chr5171337576-SPIDRchr848352885+0.0014956020.9985044

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Fusion Genomic Features for FBXW11-SPIDR


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
FBXW11chr5171337575-SPIDRchr848352884+0.0005711630.9994288
FBXW11chr5171337575-SPIDRchr848352884+0.0005711630.9994288

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for FBXW11-SPIDR


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr5:171337576/chr8:48352885)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneFBXW11chr5:171337576chr8:48352885ENST00000265094-31367_1161241360.3333333333333RegionHomodimerization domain D

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneFBXW11chr5:171337576chr8:48352885ENST00000265094-313129_1671241360.3333333333333DomainF-box
HgeneFBXW11chr5:171337576chr8:48352885ENST00000296933-313129_1671111283.6666666666667DomainF-box
HgeneFBXW11chr5:171337576chr8:48352885ENST00000393802-212129_16790592.0DomainF-box
HgeneFBXW11chr5:171337576chr8:48352885ENST00000296933-31367_1161111283.6666666666667RegionHomodimerization domain D
HgeneFBXW11chr5:171337576chr8:48352885ENST00000393802-21267_11690592.0RegionHomodimerization domain D
HgeneFBXW11chr5:171337576chr8:48352885ENST00000265094-313238_2751241360.3333333333333RepeatNote=WD 1
HgeneFBXW11chr5:171337576chr8:48352885ENST00000265094-313278_3151241360.3333333333333RepeatNote=WD 2
HgeneFBXW11chr5:171337576chr8:48352885ENST00000265094-313318_3551241360.3333333333333RepeatNote=WD 3
HgeneFBXW11chr5:171337576chr8:48352885ENST00000265094-313361_3981241360.3333333333333RepeatNote=WD 4
HgeneFBXW11chr5:171337576chr8:48352885ENST00000265094-313401_4401241360.3333333333333RepeatNote=WD 5
HgeneFBXW11chr5:171337576chr8:48352885ENST00000265094-313442_4781241360.3333333333333RepeatNote=WD 6
HgeneFBXW11chr5:171337576chr8:48352885ENST00000265094-313490_5271241360.3333333333333RepeatNote=WD 7
HgeneFBXW11chr5:171337576chr8:48352885ENST00000296933-313238_2751111283.6666666666667RepeatNote=WD 1
HgeneFBXW11chr5:171337576chr8:48352885ENST00000296933-313278_3151111283.6666666666667RepeatNote=WD 2
HgeneFBXW11chr5:171337576chr8:48352885ENST00000296933-313318_3551111283.6666666666667RepeatNote=WD 3
HgeneFBXW11chr5:171337576chr8:48352885ENST00000296933-313361_3981111283.6666666666667RepeatNote=WD 4
HgeneFBXW11chr5:171337576chr8:48352885ENST00000296933-313401_4401111283.6666666666667RepeatNote=WD 5
HgeneFBXW11chr5:171337576chr8:48352885ENST00000296933-313442_4781111283.6666666666667RepeatNote=WD 6
HgeneFBXW11chr5:171337576chr8:48352885ENST00000296933-313490_5271111283.6666666666667RepeatNote=WD 7
HgeneFBXW11chr5:171337576chr8:48352885ENST00000393802-212238_27590592.0RepeatNote=WD 1
HgeneFBXW11chr5:171337576chr8:48352885ENST00000393802-212278_31590592.0RepeatNote=WD 2
HgeneFBXW11chr5:171337576chr8:48352885ENST00000393802-212318_35590592.0RepeatNote=WD 3
HgeneFBXW11chr5:171337576chr8:48352885ENST00000393802-212361_39890592.0RepeatNote=WD 4
HgeneFBXW11chr5:171337576chr8:48352885ENST00000393802-212401_44090592.0RepeatNote=WD 5
HgeneFBXW11chr5:171337576chr8:48352885ENST00000393802-212442_47890592.0RepeatNote=WD 6
HgeneFBXW11chr5:171337576chr8:48352885ENST00000393802-212490_52790592.0RepeatNote=WD 7


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Fusion Gene Sequence for FBXW11-SPIDR


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>29889_29889_1_FBXW11-SPIDR_FBXW11_chr5_171337576_ENST00000425623_SPIDR_chr8_48352885_ENST00000297423_length(transcript)=3114nt_BP=387nt
GGAAGATGCTTGACTGCTGTCTTTTCTCAGACTAGTCTGAAAGGGAAAACCCCCATTCATTCTGGATTGGTGGATCTGAAGTACAAAATA
TTTTCCAGAACACTTCAGTTATGGAAGATCAAAATGAAGATGAGTCCCCAAAGAAAAATACTCTTTGGCAGATAAGTAATGGAACATCAT
CTGTGATCGTCTCCAGAAAGAGGCCATCAGAAGGAAACTATCAAAAAGAAAAAGACTTGTGTATTAAATATTTTGACCAGTGGTCTGAAT
CAGATCAAGTGGAATTTGTGGAACATCTTATTTCACGAATGTGTCATTATCAGCATGGACATATTAACTCTTACCTGAAGCCCATGTTGC
AGCGGGACTTTATTACCGCTTTACCAGGTAGAAAATCTGGTGTATTAACTGTGAAAATTTTAGAGCTGCATGAGGAATGTGCCATGCAAG
TTGCCATGTGTGAGCAGTTATTGGGGTCACCAGCCACCAGCTCCTCCCAAAGTGTGGCTCCCAGGCCTGGAGCTGGCCTGAAAGTTCTCT
TCACCAAGGAGACTGCAGGCTACCTCAGGGGCCGTCCCCAGGACACTGTCCGGATCTTCCCTCCCTGGCAAAAACTGATTATTCCAAGTG
GAAGTTGCCCTGTTATTCTGAATACTTACTTTTGTGAGAAAGTTGTTGCCAAAGAAGATTCAGAAAAAACTTGTGAAGTGTACTGTCCGG
ACATACCCCTTCCAAGAAGAAGCATCTCTTTGGCCCAGATGTTTGTAATTAAGGGTCTAACAAATAATTCACCTGAAATCCAGGTTGTGT
GTAGTGGTGTAGCCACTACAGGGACAGCCTGGACCCATGGGCACAAAGAAGCAAAACAGCGCATCCCAACCAGCACTCCCCTGAGGGATT
CTCTCCTGGATGTGGTGGAAAGCCAGGGAGCTGCCTCGTGGCCAGGAGCTGGAGTCCGAGTGGTGGTGCAAAGAGTGTATTCTCTTCCCA
GCAGAGACAGCACCAGGGGTCAGCAGGGGGCCAGCTCAGGACACACAGACCCAGCTGGAACTCGAGCCTGCCTTCTGGTACAAGATGCCT
GTGGAATGTTCGGTGAAGTGCACTTGGAGTTCACCATGTCGAAGGCAAGACAGTTGGAAGGGAAGTCTTGCAGCCTGGTGGGAATGAAGG
TTCTACAGAAAGTCACCAGAGGAAGGACAGCGGGGATTTTCAGTTTGATTGACACCCTGTGGCCCCCAGCGATACCTCTGAAAACACCTG
GCCGCGACCAGCCCTGTGAAGAGATAAAAACTCATCTGCCTCCTCCAGCCTTGTGTTACATCCTCACAGCTCATCCAAATCTGGGACAAA
TTGATATAATTGACGAAGACCCCATTTATAAGCTTTACCAGCCTCCAGTTACCCGCTGCTTAAGAGACATTCTCCAGATGAATGATCTTG
GTACCCGTTGCAGTTTCTATGCCACGGTGATTTACCAAAAACCACAGCTGAAGAGTCTGCTGCTTCTGGAGCAAAGGGAGATCTGGCTGC
TAGTGACCGATGTCACTCTGCAAACGAAGGAGGAGAGAGACCCCAGGCTCCCCAAAACCCTGCTGGTCTATGTGGCCCCCTTGTGTGTGC
TGGGCTCTGAAGTCCTGGAGGCACTCGCTGGGGCTGCCCCTCACAGCCTCTTCTTCAAGGACGCTCTCCGTGACCAGGGTCGGATTGTTT
GTGCTGAACGAACTGTCCTCTTGCTTCAGAAGCCCCTTTTGAGTGTGGTCTCTGGTGCAAGTTCCTGTGAGCTGCCTGGCCCGGTGATGC
TCGACAGCCTGGACTCTGCAACACCTGTCAACTCCATCTGCAGTGTTCAAGGCACTGTGGTTGGCGTGGACGAGAGCACTGCTTTCTCAT
GGCCTGTGTGTGACATGTGTGGCAACGGGAGATTGGAACAGAGGCCGGAAGACAGAGGCGCCTTTTCCTGTGGGGACTGCTCCCGGGTGG
TCACATCTCCTGTTCTCAAGAGGCACCTGCAGGTCTTCCTGGACTGCCGCTCAAGACCGCAGTGCAGAGTGAAGGTCAAGCTGTTGCAGC
GCAGCATTTCCTCCCTGCTGAGGTTTGCCGCCGGTGAAGATGGGAGCTACGAAGTGAAGAGTGTCCTCGGAAAGGAAGTGGGGTTGTTAA
ATTGTTTTGTCCAGTCCGTAACCGCCCACCCGACCAGCTGCATTGGATTGGAGGAAATCGAGCTTCTGAGTGCAGGAGGGGCCTCTGCAG
AACACTAGCGGTTGCCGCAGGATCTGTGAACTTTGCAATGTGGCTGCAAGGGTGGTGGTGGTGGTGGTGATTTGGGGTAGTTATTTGTTA
ACTATGGACACAGTGAACGTAGTTTACGATCTTGAAATGAAACTTAGATTTTTCTGGGGAAATGTTCAGATACAGTTTTGTGAACTGTAA
ATCAAAATACCTTTTTCTACAGTTTATCTTTTATTTTCTGCAAATTTAGGAACATATTTACTCGTTTTCACATTGAATCTTAAGTTTAAG
CTCTTCATTTGGTATTTAGGCAATATATGAGAAAAAAATTTTTTTTGTTCATTTGTAATTTTAACAAGTTGAACATTTTACCATGATTGA
ACATGTTTTTATTACAGTATTTAACATTCCCCCAAAGAATACCCTGCAAAGTGTAAACCTTTGTCCCATACTGTGATATTACTGTTCTGC
TACAATAAATGTCAAACCTAAGCACTTTGCAGTTCACTACTTTTGGGAAAATGTTCTAGGGAACTGTATCACAGGTGAAACTGTTACCCA
TAAAGTGTAGCTCTCTGAACTGGTGTGATCGTGTCTCTGCTGAATGGTGGTGGGGATAGCTGGCTCCACCACACACACCTGTTTTAATTA
GGCTGGGTAATGTGCACGGAGAGCAAAGATCACAGACTAAGGAGCAGTCAGTCGGATATTTGCTTTGCTGGCAAAGATTTAAACCAAGAA
TTAATTATCTTTGGACACTATAAAGATTTTGTTCCCTTCCTTATAGCAATATAATCATGACAGGCCATGGTTAACTACATCAGATACACG

>29889_29889_1_FBXW11-SPIDR_FBXW11_chr5_171337576_ENST00000425623_SPIDR_chr8_48352885_ENST00000297423_length(amino acids)=715AA_BP=90
MEDQNEDESPKKNTLWQISNGTSSVIVSRKRPSEGNYQKEKDLCIKYFDQWSESDQVEFVEHLISRMCHYQHGHINSYLKPMLQRDFITA
LPGRKSGVLTVKILELHEECAMQVAMCEQLLGSPATSSSQSVAPRPGAGLKVLFTKETAGYLRGRPQDTVRIFPPWQKLIIPSGSCPVIL
NTYFCEKVVAKEDSEKTCEVYCPDIPLPRRSISLAQMFVIKGLTNNSPEIQVVCSGVATTGTAWTHGHKEAKQRIPTSTPLRDSLLDVVE
SQGAASWPGAGVRVVVQRVYSLPSRDSTRGQQGASSGHTDPAGTRACLLVQDACGMFGEVHLEFTMSKARQLEGKSCSLVGMKVLQKVTR
GRTAGIFSLIDTLWPPAIPLKTPGRDQPCEEIKTHLPPPALCYILTAHPNLGQIDIIDEDPIYKLYQPPVTRCLRDILQMNDLGTRCSFY
ATVIYQKPQLKSLLLLEQREIWLLVTDVTLQTKEERDPRLPKTLLVYVAPLCVLGSEVLEALAGAAPHSLFFKDALRDQGRIVCAERTVL
LLQKPLLSVVSGASSCELPGPVMLDSLDSATPVNSICSVQGTVVGVDESTAFSWPVCDMCGNGRLEQRPEDRGAFSCGDCSRVVTSPVLK

--------------------------------------------------------------
>29889_29889_2_FBXW11-SPIDR_FBXW11_chr5_171337576_ENST00000425623_SPIDR_chr8_48352885_ENST00000518074_length(transcript)=2338nt_BP=387nt
GGAAGATGCTTGACTGCTGTCTTTTCTCAGACTAGTCTGAAAGGGAAAACCCCCATTCATTCTGGATTGGTGGATCTGAAGTACAAAATA
TTTTCCAGAACACTTCAGTTATGGAAGATCAAAATGAAGATGAGTCCCCAAAGAAAAATACTCTTTGGCAGATAAGTAATGGAACATCAT
CTGTGATCGTCTCCAGAAAGAGGCCATCAGAAGGAAACTATCAAAAAGAAAAAGACTTGTGTATTAAATATTTTGACCAGTGGTCTGAAT
CAGATCAAGTGGAATTTGTGGAACATCTTATTTCACGAATGTGTCATTATCAGCATGGACATATTAACTCTTACCTGAAGCCCATGTTGC
AGCGGGACTTTATTACCGCTTTACCAGGTAGAAAATCTGGTGTATTAACTGTGAAAATTTTAGAGCTGCATGAGGAATGTGCCATGCAAG
TTGCCATGTGTGAGCAGTTATTGGGGTCACCAGCCACCAGCTCCTCCCAAAGTGTGGCTCCCAGGCCTGGAGCTGGCCTGAAAGTTCTCT
TCACCAAGGAGACTGCAGGCTACCTCAGGGGCCGTCCCCAGGACACTGTCCGGATCTTCCCTCCCTGGCAAAAACTGATTATTCCAAGTG
GAAGTTGCCCTGTTATTCTGAATACTTACTTTTGTGAGAAAGTTGTTGCCAAAGAAGATTCAGAAAAAACTTGTGAAGTGTACTGTCCGG
ACATACCCCTTCCAAGAAGAAGCATCTCTTTGGCCCAGATGTTTGTAATTAAGGGTCTAACAAATAATTCACCTGAAATCCAGGTTGTGT
GTAGTGGTGTAGCCACTACAGGGACAGCCTGGACCCATGGGCACAAAGAAGCAAAACAGCGCATCCCAACCAGCACTCCCCTGAGGGATT
CTCTCCTGGATGTGGTGGAAAGCCAGGGAGCTGCCTCGTGGCCAGGAGCTGGAGTCCGAGTGGTGGTGCAAAGAGTGTATTCTCTTCCCA
GCAGAGACAGCACCAGGGGTCAGCAGGGGGCCAGCTCAGGACACACAGACCCAGCTGGAACTCGAGCCTGCCTTCTGGTACAAGATGCCT
GTGGAATGTTCGGTGAAGTGCACTTGGAGTTCACCATGTCGAAGGCAAGACAGTTGGAAGGGAAGTCTTGCAGCCTGGTGGGAATGAAGG
TTCTACAGAAAGTCACCAGAGGAAGGACAGCGGGGATTTTCAGTTTGATTGACACCCTGTGGCCCCCAGCGATACCTCTGAAAACACCTG
GCCGCGACCAGCCCTGTGAAGAGATAAAAACTCATCTGCCTCCTCCAGCCTTGTGTTACATCCTCACAGCTCATCCAAATCTGGGACAAA
TTGATATAATTGACGAAGACCCCATTTATAAGCTTTACCAGCCTCCAGTTACCCGCTGCTTAAGAGACATTCTCCAGATGAATGATCTTG
GTACCCGTTGCAGTTTCTATGCCACGGTGATTTACCAAAAACCACAGCTGAAGAGTCTGCTGCTTCTGGAGCAAAGGGAGATCTGGCTGC
TAGTGACCGATGTCACTCTGCAAACGAAGGAGGAGAGAGACCCCAGGCTCCCCAAAACCCTGCTGGTCTATGTGGCCCCCTTGTGTGTGC
TGGGCTCTGAAGTCCTGGAGGCACTCGCTGGGGCTGCCCCTCACAGCCTCTTCTTCAAGGACGCTCTCCGTGACCAGGGTCGGATTGTTT
GTGCTGAACGAACTGTCCTCTTGCTTCAGAAGCCCCTTTTGAGTGTGGTCTCTGGTGCAAGTTCCTGTGAGCTGCCTGGCCCGGTGATGC
TCGACAGCCTGGACTCTGCAACACCTGTCAACTCCATCTGCAGTGTTCAAGGCACTGTGGTTGGCGTGGACGAGAGCACTGCTTTCTCAT
GGCCTGTGTGTGACATGTGTGGCAACGGGAGATTGGAACAGAGGCCGGAAGACAGAGGCGCCTTTTCCTGTGGGGACTGCTCCCGGGTGG
TCACATCTCCTGTTCTCAAGAGGCACCTGCAGGTCTTCCTGGACTGCCGCTCAAGACCGCAGTGCAGAGTGAAGGTCAAGGTAGGAGCCA
GGCCAGAGCACGCACGCACTCCTAGCTCACTCCAACATAGCGAAGAGCTACGAAGTGAAGAGTGTCCTCGGAAAGGAAGTGGGGTTGTTA
AATTGTTTTGTCCAGTCCGTAACCGCCCACCCGACCAGCTGCATTGGATTGGAGGAAATCGAGCTTCTGAGTGCAGGAGGGGCCTCTGCA

>29889_29889_2_FBXW11-SPIDR_FBXW11_chr5_171337576_ENST00000425623_SPIDR_chr8_48352885_ENST00000518074_length(amino acids)=736AA_BP=90
MEDQNEDESPKKNTLWQISNGTSSVIVSRKRPSEGNYQKEKDLCIKYFDQWSESDQVEFVEHLISRMCHYQHGHINSYLKPMLQRDFITA
LPGRKSGVLTVKILELHEECAMQVAMCEQLLGSPATSSSQSVAPRPGAGLKVLFTKETAGYLRGRPQDTVRIFPPWQKLIIPSGSCPVIL
NTYFCEKVVAKEDSEKTCEVYCPDIPLPRRSISLAQMFVIKGLTNNSPEIQVVCSGVATTGTAWTHGHKEAKQRIPTSTPLRDSLLDVVE
SQGAASWPGAGVRVVVQRVYSLPSRDSTRGQQGASSGHTDPAGTRACLLVQDACGMFGEVHLEFTMSKARQLEGKSCSLVGMKVLQKVTR
GRTAGIFSLIDTLWPPAIPLKTPGRDQPCEEIKTHLPPPALCYILTAHPNLGQIDIIDEDPIYKLYQPPVTRCLRDILQMNDLGTRCSFY
ATVIYQKPQLKSLLLLEQREIWLLVTDVTLQTKEERDPRLPKTLLVYVAPLCVLGSEVLEALAGAAPHSLFFKDALRDQGRIVCAERTVL
LLQKPLLSVVSGASSCELPGPVMLDSLDSATPVNSICSVQGTVVGVDESTAFSWPVCDMCGNGRLEQRPEDRGAFSCGDCSRVVTSPVLK
RHLQVFLDCRSRPQCRVKVKVGARPEHARTPSSLQHSEELRSEECPRKGSGVVKLFCPVRNRPPDQLHWIGGNRASECRRGLCRTLAVAA

--------------------------------------------------------------
>29889_29889_3_FBXW11-SPIDR_FBXW11_chr5_171337576_ENST00000425623_SPIDR_chr8_48352885_ENST00000541342_length(transcript)=2319nt_BP=387nt
GGAAGATGCTTGACTGCTGTCTTTTCTCAGACTAGTCTGAAAGGGAAAACCCCCATTCATTCTGGATTGGTGGATCTGAAGTACAAAATA
TTTTCCAGAACACTTCAGTTATGGAAGATCAAAATGAAGATGAGTCCCCAAAGAAAAATACTCTTTGGCAGATAAGTAATGGAACATCAT
CTGTGATCGTCTCCAGAAAGAGGCCATCAGAAGGAAACTATCAAAAAGAAAAAGACTTGTGTATTAAATATTTTGACCAGTGGTCTGAAT
CAGATCAAGTGGAATTTGTGGAACATCTTATTTCACGAATGTGTCATTATCAGCATGGACATATTAACTCTTACCTGAAGCCCATGTTGC
AGCGGGACTTTATTACCGCTTTACCAGGTAGAAAATCTGGTGTATTAACTGTGAAAATTTTAGAGCTGCATGAGGAATGTGCCATGCAAG
TTGCCATGTGTGAGCAGTTATTGGGGTCACCAGCCACCAGCTCCTCCCAAAGTGTGGCTCCCAGGCCTGGAGCTGGCCTGAAAGTTCTCT
TCACCAAGGAGACTGCAGGCTACCTCAGGGGCCGTCCCCAGGACACTGTCCGGATCTTCCCTCCCTGGCAAAAACTGATTATTCCAAGTG
GAAGTTGCCCTGTTATTCTGAATACTTACTTTTGTGAGAAAGTTGTTGCCAAAGAAGATTCAGAAAAAACTTGTGAAGTGTACTGTCCGG
ACATACCCCTTCCAAGAAGAAGCATCTCTTTGGCCCAGATGTTTGTAATTAAGGGTCTAACAAATAATTCACCTGAAATCCAGGTTGTGT
GTAGTGGTGTAGCCACTACAGGGACAGCCTGGACCCATGGGCACAAAGAAGCAAAACAGCGCATCCCAACCAGCACTCCCCTGAGGGATT
CTCTCCTGGATGTGGTGGAAAGCCAGGGAGCTGCCTCGTGGCCAGGAGCTGGAGTCCGAGTGGTGGTGCAAAGAGTGTATTCTCTTCCCA
GCAGAGACAGCACCAGGGGTCAGCAGGGGGCCAGCTCAGGACACACAGACCCAGCTGGAACTCGAGCCTGCCTTCTGGTACAAGATGCCT
GTGGAATGTTCGGTGAAGTGCACTTGGAGTTCACCATGTCGAAGGCAAGACAGTTGGAAGGGAAGTCTTGCAGCCTGGTGGGAATGAAGG
TTCTACAGAAAGTCACCAGAGGAAGGACAGCGGGGATTTTCAGTTTGATTGACACCCTGTGGCCCCCAGCGATACCTCTGAAAACACCTG
GCCGCGACCAGCCCTGTGAAGAGATAAAAACTCATCTGCCTCCTCCAGCCTTGTGTTACATCCTCACAGCTCATCCAAATCTGGGACAAA
TTGATATAATTGACGAAGACCCCATTTATAAGCTTTACCAGCCTCCAGTTACCCGCTGCTTAAGAGACATTCTCCAGATGAATGATCTTG
GTACCCGTTGCAGTTTCTATGCCACGGTGATTTACCAAAAACCACAGCTGAAGAGTCTGCTGCTTCTGGAGCAAAGGGAGATCTGGCTGC
TAGTGACCGATGTCACTCTGCAAACGAAGGAGGAGAGAGACCCCAGGCTCCCCAAAACCCTGCTGGTCTATGTGGCCCCCTTGTGTGTGC
TGGGCTCTGAAGTCCTGGAGGCACTCGCTGGGGCTGCCCCTCACAGCCTCTTCTTCAAGGACGCTCTCCGTGACCAGGGTCGGATTGTTT
GTGCTGAACGAACTGTCCTCTTGCTTCAGAAGCCCCTTTTGAGTGTGGTCTCTGGTGCAAGTTCCTGTGAGCTGCCTGGCCCGGTGATGC
TCGACAGCCTGGACTCTGCAACACCTGTCAACTCCATCTGCAGTGTTCAAGGCACTGTGGTTGGCGTGGACGAGAGCACTGCTTTCTCAT
GGCCTGTGTGTGACATGTGTGGCAACGGGAGATTGGAACAGAGGCCGGAAGACAGAGGCGCCTTTTCCTGTGGGGACTGCTCCCGGGTGG
TCACATCTCCTGTTCTCAAGAGGCACCTGCAGGTCTTCCTGGACTGCCGCTCAAGACCGCAGTGCAGAGTGAAGGTCAAGCTGTTGCAGC
GCAGCATTTCCTCCCTGCTGAGGTTTGCCGCCGGTGAAGATGGGAGCTACGAAGTGAAGAGTGTCCTCGGAAAGGAAGTGGGGTTGTTAA
ATTGTTTTGTCCAGTCCGTAACCGCCCACCCGACCAGCTGCATTGGATTGGAGGAAATCGAGCTTCTGAGTGCAGGAGGGGCCTCTGCAG

>29889_29889_3_FBXW11-SPIDR_FBXW11_chr5_171337576_ENST00000425623_SPIDR_chr8_48352885_ENST00000541342_length(amino acids)=715AA_BP=90
MEDQNEDESPKKNTLWQISNGTSSVIVSRKRPSEGNYQKEKDLCIKYFDQWSESDQVEFVEHLISRMCHYQHGHINSYLKPMLQRDFITA
LPGRKSGVLTVKILELHEECAMQVAMCEQLLGSPATSSSQSVAPRPGAGLKVLFTKETAGYLRGRPQDTVRIFPPWQKLIIPSGSCPVIL
NTYFCEKVVAKEDSEKTCEVYCPDIPLPRRSISLAQMFVIKGLTNNSPEIQVVCSGVATTGTAWTHGHKEAKQRIPTSTPLRDSLLDVVE
SQGAASWPGAGVRVVVQRVYSLPSRDSTRGQQGASSGHTDPAGTRACLLVQDACGMFGEVHLEFTMSKARQLEGKSCSLVGMKVLQKVTR
GRTAGIFSLIDTLWPPAIPLKTPGRDQPCEEIKTHLPPPALCYILTAHPNLGQIDIIDEDPIYKLYQPPVTRCLRDILQMNDLGTRCSFY
ATVIYQKPQLKSLLLLEQREIWLLVTDVTLQTKEERDPRLPKTLLVYVAPLCVLGSEVLEALAGAAPHSLFFKDALRDQGRIVCAERTVL
LLQKPLLSVVSGASSCELPGPVMLDSLDSATPVNSICSVQGTVVGVDESTAFSWPVCDMCGNGRLEQRPEDRGAFSCGDCSRVVTSPVLK

--------------------------------------------------------------

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Fusion Gene PPI Analysis for FBXW11-SPIDR


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for FBXW11-SPIDR


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for FBXW11-SPIDR


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneFBXW11C0557874Global developmental delay1GENOMICS_ENGLAND
HgeneFBXW11C2677504AUTISM, SUSCEPTIBILITY TO, 151GENOMICS_ENGLAND
HgeneFBXW11C3550704Abnormality of digit1GENOMICS_ENGLAND
HgeneFBXW11C3714756Intellectual Disability1GENOMICS_ENGLAND
HgeneFBXW11C4021812Abnormality of the head1GENOMICS_ENGLAND
HgeneFBXW11C4316870Abnormality of the eye1GENOMICS_ENGLAND
TgeneC0685837Pure Gonadal Dysgenesis, 46, XX1ORPHANET
TgeneC0949595Gonadal Dysgenesis, 46,XX1ORPHANET