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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Diseases

Fusion gene:SMG6-WDR20 (FusionGDB2 ID:HG23293TG91833)

Fusion Gene Summary for SMG6-WDR20

check button Fusion gene summary
Fusion gene informationFusion gene name: SMG6-WDR20
Fusion gene ID: hg23293tg91833
HgeneTgene
Gene symbol

SMG6

WDR20

Gene ID

23293

91833

Gene nameSMG6 nonsense mediated mRNA decay factorWD repeat domain 20
SynonymsC17orf31|EST1A|SMG-6|hSMG5/7aDMR
Cytomap('SMG6')('WDR20')

17p13.3

14q32.31

Type of geneprotein-codingprotein-coding
Descriptiontelomerase-binding protein EST1AEST1 telomerase component homolog Aever shorter telomeres 1Asmg-6 homolog, nonsense mediated mRNA decay factortelomerase subunit EST1AWD repeat-containing protein 20
Modification date2020032020200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000263073, ENST00000544865, 
ENST00000354901, ENST00000536871, 
ENST00000573166, 
Fusion gene scores* DoF score19 X 14 X 6=15965 X 5 X 6=150
# samples 197
** MAII scorelog2(19/1596*10)=-3.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(7/150*10)=-1.09953567355091
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SMG6 [Title/Abstract] AND WDR20 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointSMG6(2206927)-WDR20(102661275), # samples:2
SMG6(2206308)-WDR20(102661275), # samples:2
Anticipated loss of major functional domain due to fusion event.SMG6-WDR20 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
SMG6-WDR20 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneSMG6

GO:1904354

negative regulation of telomere capping

12676087


check buttonFusion gene breakpoints across SMG6 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across WDR20 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-A2-A25B-01ASMG6chr17

2206308

-WDR20chr14

102661275

+
ChimerDB4BRCATCGA-A2-A25B-01ASMG6chr17

2206927

-WDR20chr14

102661275

+


Top

Fusion Gene ORF analysis for SMG6-WDR20

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000263073ENST00000557186SMG6chr17

2206927

-WDR20chr14

102661275

+
5CDS-5UTRENST00000263073ENST00000342702SMG6chr17

2206927

-WDR20chr14

102661275

+
5CDS-5UTRENST00000263073ENST00000499851SMG6chr17

2206927

-WDR20chr14

102661275

+
5CDS-5UTRENST00000263073ENST00000545563SMG6chr17

2206927

-WDR20chr14

102661275

+
5CDS-intronENST00000263073ENST00000299135SMG6chr17

2206927

-WDR20chr14

102661275

+
5CDS-intronENST00000263073ENST00000322340SMG6chr17

2206927

-WDR20chr14

102661275

+
5CDS-intronENST00000263073ENST00000424963SMG6chr17

2206927

-WDR20chr14

102661275

+
5CDS-intronENST00000263073ENST00000454394SMG6chr17

2206927

-WDR20chr14

102661275

+
5CDS-intronENST00000263073ENST00000556511SMG6chr17

2206927

-WDR20chr14

102661275

+
5CDS-intronENST00000263073ENST00000556807SMG6chr17

2206927

-WDR20chr14

102661275

+
5CDS-intronENST00000263073ENST00000558567SMG6chr17

2206927

-WDR20chr14

102661275

+
5UTR-3CDSENST00000544865ENST00000335263SMG6chr17

2206308

-WDR20chr14

102661275

+
5UTR-3UTRENST00000544865ENST00000557186SMG6chr17

2206308

-WDR20chr14

102661275

+
5UTR-5UTRENST00000544865ENST00000342702SMG6chr17

2206308

-WDR20chr14

102661275

+
5UTR-5UTRENST00000544865ENST00000499851SMG6chr17

2206308

-WDR20chr14

102661275

+
5UTR-5UTRENST00000544865ENST00000545563SMG6chr17

2206308

-WDR20chr14

102661275

+
5UTR-intronENST00000544865ENST00000299135SMG6chr17

2206308

-WDR20chr14

102661275

+
5UTR-intronENST00000544865ENST00000322340SMG6chr17

2206308

-WDR20chr14

102661275

+
5UTR-intronENST00000544865ENST00000424963SMG6chr17

2206308

-WDR20chr14

102661275

+
5UTR-intronENST00000544865ENST00000454394SMG6chr17

2206308

-WDR20chr14

102661275

+
5UTR-intronENST00000544865ENST00000556511SMG6chr17

2206308

-WDR20chr14

102661275

+
5UTR-intronENST00000544865ENST00000556807SMG6chr17

2206308

-WDR20chr14

102661275

+
5UTR-intronENST00000544865ENST00000558567SMG6chr17

2206308

-WDR20chr14

102661275

+
In-frameENST00000263073ENST00000335263SMG6chr17

2206927

-WDR20chr14

102661275

+
intron-3CDSENST00000263073ENST00000335263SMG6chr17

2206308

-WDR20chr14

102661275

+
intron-3CDSENST00000354901ENST00000335263SMG6chr17

2206308

-WDR20chr14

102661275

+
intron-3CDSENST00000354901ENST00000335263SMG6chr17

2206927

-WDR20chr14

102661275

+
intron-3CDSENST00000536871ENST00000335263SMG6chr17

2206308

-WDR20chr14

102661275

+
intron-3CDSENST00000536871ENST00000335263SMG6chr17

2206927

-WDR20chr14

102661275

+
intron-3CDSENST00000544865ENST00000335263SMG6chr17

2206927

-WDR20chr14

102661275

+
intron-3CDSENST00000573166ENST00000335263SMG6chr17

2206308

-WDR20chr14

102661275

+
intron-3CDSENST00000573166ENST00000335263SMG6chr17

2206927

-WDR20chr14

102661275

+
intron-3UTRENST00000263073ENST00000557186SMG6chr17

2206308

-WDR20chr14

102661275

+
intron-3UTRENST00000354901ENST00000557186SMG6chr17

2206308

-WDR20chr14

102661275

+
intron-3UTRENST00000354901ENST00000557186SMG6chr17

2206927

-WDR20chr14

102661275

+
intron-3UTRENST00000536871ENST00000557186SMG6chr17

2206308

-WDR20chr14

102661275

+
intron-3UTRENST00000536871ENST00000557186SMG6chr17

2206927

-WDR20chr14

102661275

+
intron-3UTRENST00000544865ENST00000557186SMG6chr17

2206927

-WDR20chr14

102661275

+
intron-3UTRENST00000573166ENST00000557186SMG6chr17

2206308

-WDR20chr14

102661275

+
intron-3UTRENST00000573166ENST00000557186SMG6chr17

2206927

-WDR20chr14

102661275

+
intron-5UTRENST00000263073ENST00000342702SMG6chr17

2206308

-WDR20chr14

102661275

+
intron-5UTRENST00000263073ENST00000499851SMG6chr17

2206308

-WDR20chr14

102661275

+
intron-5UTRENST00000263073ENST00000545563SMG6chr17

2206308

-WDR20chr14

102661275

+
intron-5UTRENST00000354901ENST00000342702SMG6chr17

2206308

-WDR20chr14

102661275

+
intron-5UTRENST00000354901ENST00000342702SMG6chr17

2206927

-WDR20chr14

102661275

+
intron-5UTRENST00000354901ENST00000499851SMG6chr17

2206308

-WDR20chr14

102661275

+
intron-5UTRENST00000354901ENST00000499851SMG6chr17

2206927

-WDR20chr14

102661275

+
intron-5UTRENST00000354901ENST00000545563SMG6chr17

2206308

-WDR20chr14

102661275

+
intron-5UTRENST00000354901ENST00000545563SMG6chr17

2206927

-WDR20chr14

102661275

+
intron-5UTRENST00000536871ENST00000342702SMG6chr17

2206308

-WDR20chr14

102661275

+
intron-5UTRENST00000536871ENST00000342702SMG6chr17

2206927

-WDR20chr14

102661275

+
intron-5UTRENST00000536871ENST00000499851SMG6chr17

2206308

-WDR20chr14

102661275

+
intron-5UTRENST00000536871ENST00000499851SMG6chr17

2206927

-WDR20chr14

102661275

+
intron-5UTRENST00000536871ENST00000545563SMG6chr17

2206308

-WDR20chr14

102661275

+
intron-5UTRENST00000536871ENST00000545563SMG6chr17

2206927

-WDR20chr14

102661275

+
intron-5UTRENST00000544865ENST00000342702SMG6chr17

2206927

-WDR20chr14

102661275

+
intron-5UTRENST00000544865ENST00000499851SMG6chr17

2206927

-WDR20chr14

102661275

+
intron-5UTRENST00000544865ENST00000545563SMG6chr17

2206927

-WDR20chr14

102661275

+
intron-5UTRENST00000573166ENST00000342702SMG6chr17

2206308

-WDR20chr14

102661275

+
intron-5UTRENST00000573166ENST00000342702SMG6chr17

2206927

-WDR20chr14

102661275

+
intron-5UTRENST00000573166ENST00000499851SMG6chr17

2206308

-WDR20chr14

102661275

+
intron-5UTRENST00000573166ENST00000499851SMG6chr17

2206927

-WDR20chr14

102661275

+
intron-5UTRENST00000573166ENST00000545563SMG6chr17

2206308

-WDR20chr14

102661275

+
intron-5UTRENST00000573166ENST00000545563SMG6chr17

2206927

-WDR20chr14

102661275

+
intron-intronENST00000263073ENST00000299135SMG6chr17

2206308

-WDR20chr14

102661275

+
intron-intronENST00000263073ENST00000322340SMG6chr17

2206308

-WDR20chr14

102661275

+
intron-intronENST00000263073ENST00000424963SMG6chr17

2206308

-WDR20chr14

102661275

+
intron-intronENST00000263073ENST00000454394SMG6chr17

2206308

-WDR20chr14

102661275

+
intron-intronENST00000263073ENST00000556511SMG6chr17

2206308

-WDR20chr14

102661275

+
intron-intronENST00000263073ENST00000556807SMG6chr17

2206308

-WDR20chr14

102661275

+
intron-intronENST00000263073ENST00000558567SMG6chr17

2206308

-WDR20chr14

102661275

+
intron-intronENST00000354901ENST00000299135SMG6chr17

2206308

-WDR20chr14

102661275

+
intron-intronENST00000354901ENST00000299135SMG6chr17

2206927

-WDR20chr14

102661275

+
intron-intronENST00000354901ENST00000322340SMG6chr17

2206308

-WDR20chr14

102661275

+
intron-intronENST00000354901ENST00000322340SMG6chr17

2206927

-WDR20chr14

102661275

+
intron-intronENST00000354901ENST00000424963SMG6chr17

2206308

-WDR20chr14

102661275

+
intron-intronENST00000354901ENST00000424963SMG6chr17

2206927

-WDR20chr14

102661275

+
intron-intronENST00000354901ENST00000454394SMG6chr17

2206308

-WDR20chr14

102661275

+
intron-intronENST00000354901ENST00000454394SMG6chr17

2206927

-WDR20chr14

102661275

+
intron-intronENST00000354901ENST00000556511SMG6chr17

2206308

-WDR20chr14

102661275

+
intron-intronENST00000354901ENST00000556511SMG6chr17

2206927

-WDR20chr14

102661275

+
intron-intronENST00000354901ENST00000556807SMG6chr17

2206308

-WDR20chr14

102661275

+
intron-intronENST00000354901ENST00000556807SMG6chr17

2206927

-WDR20chr14

102661275

+
intron-intronENST00000354901ENST00000558567SMG6chr17

2206308

-WDR20chr14

102661275

+
intron-intronENST00000354901ENST00000558567SMG6chr17

2206927

-WDR20chr14

102661275

+
intron-intronENST00000536871ENST00000299135SMG6chr17

2206308

-WDR20chr14

102661275

+
intron-intronENST00000536871ENST00000299135SMG6chr17

2206927

-WDR20chr14

102661275

+
intron-intronENST00000536871ENST00000322340SMG6chr17

2206308

-WDR20chr14

102661275

+
intron-intronENST00000536871ENST00000322340SMG6chr17

2206927

-WDR20chr14

102661275

+
intron-intronENST00000536871ENST00000424963SMG6chr17

2206308

-WDR20chr14

102661275

+
intron-intronENST00000536871ENST00000424963SMG6chr17

2206927

-WDR20chr14

102661275

+
intron-intronENST00000536871ENST00000454394SMG6chr17

2206308

-WDR20chr14

102661275

+
intron-intronENST00000536871ENST00000454394SMG6chr17

2206927

-WDR20chr14

102661275

+
intron-intronENST00000536871ENST00000556511SMG6chr17

2206308

-WDR20chr14

102661275

+
intron-intronENST00000536871ENST00000556511SMG6chr17

2206927

-WDR20chr14

102661275

+
intron-intronENST00000536871ENST00000556807SMG6chr17

2206308

-WDR20chr14

102661275

+
intron-intronENST00000536871ENST00000556807SMG6chr17

2206927

-WDR20chr14

102661275

+
intron-intronENST00000536871ENST00000558567SMG6chr17

2206308

-WDR20chr14

102661275

+
intron-intronENST00000536871ENST00000558567SMG6chr17

2206927

-WDR20chr14

102661275

+
intron-intronENST00000544865ENST00000299135SMG6chr17

2206927

-WDR20chr14

102661275

+
intron-intronENST00000544865ENST00000322340SMG6chr17

2206927

-WDR20chr14

102661275

+
intron-intronENST00000544865ENST00000424963SMG6chr17

2206927

-WDR20chr14

102661275

+
intron-intronENST00000544865ENST00000454394SMG6chr17

2206927

-WDR20chr14

102661275

+
intron-intronENST00000544865ENST00000556511SMG6chr17

2206927

-WDR20chr14

102661275

+
intron-intronENST00000544865ENST00000556807SMG6chr17

2206927

-WDR20chr14

102661275

+
intron-intronENST00000544865ENST00000558567SMG6chr17

2206927

-WDR20chr14

102661275

+
intron-intronENST00000573166ENST00000299135SMG6chr17

2206308

-WDR20chr14

102661275

+
intron-intronENST00000573166ENST00000299135SMG6chr17

2206927

-WDR20chr14

102661275

+
intron-intronENST00000573166ENST00000322340SMG6chr17

2206308

-WDR20chr14

102661275

+
intron-intronENST00000573166ENST00000322340SMG6chr17

2206927

-WDR20chr14

102661275

+
intron-intronENST00000573166ENST00000424963SMG6chr17

2206308

-WDR20chr14

102661275

+
intron-intronENST00000573166ENST00000424963SMG6chr17

2206927

-WDR20chr14

102661275

+
intron-intronENST00000573166ENST00000454394SMG6chr17

2206308

-WDR20chr14

102661275

+
intron-intronENST00000573166ENST00000454394SMG6chr17

2206927

-WDR20chr14

102661275

+
intron-intronENST00000573166ENST00000556511SMG6chr17

2206308

-WDR20chr14

102661275

+
intron-intronENST00000573166ENST00000556511SMG6chr17

2206927

-WDR20chr14

102661275

+
intron-intronENST00000573166ENST00000556807SMG6chr17

2206308

-WDR20chr14

102661275

+
intron-intronENST00000573166ENST00000556807SMG6chr17

2206927

-WDR20chr14

102661275

+
intron-intronENST00000573166ENST00000558567SMG6chr17

2206308

-WDR20chr14

102661275

+
intron-intronENST00000573166ENST00000558567SMG6chr17

2206927

-WDR20chr14

102661275

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000263073SMG6chr172206927-ENST00000335263WDR20chr14102661275+24261391481635495

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000263073ENST00000335263SMG6chr172206927-WDR20chr14102661275+0.002974050.9970259

Top

Fusion Genomic Features for SMG6-WDR20


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
SMG6chr172206307-WDR20chr14102661274+2.01E-070.99999976
SMG6chr172206926-WDR20chr14102661274+9.90E-111
SMG6chr172206307-WDR20chr14102661274+2.01E-070.99999976
SMG6chr172206926-WDR20chr14102661274+9.90E-111

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

Top

Fusion Protein Features for SMG6-WDR20


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:2206927/chr14:102661275)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneWDR20chr17:2206927chr14:102661275ENST0000029913503139_2100640.6666666666666RepeatNote=WD 2
TgeneWDR20chr17:2206927chr14:102661275ENST0000029913503211_2520640.6666666666666RepeatNote=WD 3
TgeneWDR20chr17:2206927chr14:102661275ENST0000029913503253_3310640.6666666666666RepeatNote=WD 4
TgeneWDR20chr17:2206927chr14:102661275ENST0000029913503332_4260640.6666666666666RepeatNote=WD 5
TgeneWDR20chr17:2206927chr14:102661275ENST0000029913503427_5230640.6666666666666RepeatNote=WD 6
TgeneWDR20chr17:2206927chr14:102661275ENST0000029913503524_5590640.6666666666666RepeatNote=WD 7
TgeneWDR20chr17:2206927chr14:102661275ENST000002991350394_1380640.6666666666666RepeatNote=WD 1
TgeneWDR20chr17:2206927chr14:102661275ENST0000032234004139_21083196.0RepeatNote=WD 2
TgeneWDR20chr17:2206927chr14:102661275ENST0000032234004211_25283196.0RepeatNote=WD 3
TgeneWDR20chr17:2206927chr14:102661275ENST0000032234004253_33183196.0RepeatNote=WD 4
TgeneWDR20chr17:2206927chr14:102661275ENST0000032234004332_42683196.0RepeatNote=WD 5
TgeneWDR20chr17:2206927chr14:102661275ENST0000032234004427_52383196.0RepeatNote=WD 6
TgeneWDR20chr17:2206927chr14:102661275ENST0000032234004524_55983196.0RepeatNote=WD 7
TgeneWDR20chr17:2206927chr14:102661275ENST000003223400494_13883196.0RepeatNote=WD 1
TgeneWDR20chr17:2206927chr14:102661275ENST0000033526304139_21083582.0RepeatNote=WD 2
TgeneWDR20chr17:2206927chr14:102661275ENST0000033526304211_25283582.0RepeatNote=WD 3
TgeneWDR20chr17:2206927chr14:102661275ENST0000033526304253_33183582.0RepeatNote=WD 4
TgeneWDR20chr17:2206927chr14:102661275ENST0000033526304332_42683582.0RepeatNote=WD 5
TgeneWDR20chr17:2206927chr14:102661275ENST0000033526304427_52383582.0RepeatNote=WD 6
TgeneWDR20chr17:2206927chr14:102661275ENST0000033526304524_55983582.0RepeatNote=WD 7
TgeneWDR20chr17:2206927chr14:102661275ENST000003352630494_13883582.0RepeatNote=WD 1
TgeneWDR20chr17:2206927chr14:102661275ENST0000034270203139_21083570.0RepeatNote=WD 2
TgeneWDR20chr17:2206927chr14:102661275ENST0000034270203211_25283570.0RepeatNote=WD 3
TgeneWDR20chr17:2206927chr14:102661275ENST0000034270203253_33183570.0RepeatNote=WD 4
TgeneWDR20chr17:2206927chr14:102661275ENST0000034270203332_42683570.0RepeatNote=WD 5
TgeneWDR20chr17:2206927chr14:102661275ENST0000034270203427_52383570.0RepeatNote=WD 6
TgeneWDR20chr17:2206927chr14:102661275ENST0000034270203524_55983570.0RepeatNote=WD 7
TgeneWDR20chr17:2206927chr14:102661275ENST000003427020394_13883570.0RepeatNote=WD 1
TgeneWDR20chr17:2206927chr14:102661275ENST0000045439404139_21083601.0RepeatNote=WD 2
TgeneWDR20chr17:2206927chr14:102661275ENST0000045439404211_25283601.0RepeatNote=WD 3
TgeneWDR20chr17:2206927chr14:102661275ENST0000045439404253_33183601.0RepeatNote=WD 4
TgeneWDR20chr17:2206927chr14:102661275ENST0000045439404332_42683601.0RepeatNote=WD 5
TgeneWDR20chr17:2206927chr14:102661275ENST0000045439404427_52383601.0RepeatNote=WD 6
TgeneWDR20chr17:2206927chr14:102661275ENST0000045439404524_55983601.0RepeatNote=WD 7
TgeneWDR20chr17:2206927chr14:102661275ENST000004543940494_13883601.0RepeatNote=WD 1
TgeneWDR20chr17:2206927chr14:102661275ENST0000055651102139_2100509.0RepeatNote=WD 2
TgeneWDR20chr17:2206927chr14:102661275ENST0000055651102211_2520509.0RepeatNote=WD 3
TgeneWDR20chr17:2206927chr14:102661275ENST0000055651102253_3310509.0RepeatNote=WD 4
TgeneWDR20chr17:2206927chr14:102661275ENST0000055651102332_4260509.0RepeatNote=WD 5
TgeneWDR20chr17:2206927chr14:102661275ENST0000055651102427_5230509.0RepeatNote=WD 6
TgeneWDR20chr17:2206927chr14:102661275ENST0000055651102524_5590509.0RepeatNote=WD 7
TgeneWDR20chr17:2206927chr14:102661275ENST000005565110294_1380509.0RepeatNote=WD 1
TgeneWDR20chr17:2206927chr14:102661275ENST0000055680703139_2100521.0RepeatNote=WD 2
TgeneWDR20chr17:2206927chr14:102661275ENST0000055680703211_2520521.0RepeatNote=WD 3
TgeneWDR20chr17:2206927chr14:102661275ENST0000055680703253_3310521.0RepeatNote=WD 4
TgeneWDR20chr17:2206927chr14:102661275ENST0000055680703332_4260521.0RepeatNote=WD 5
TgeneWDR20chr17:2206927chr14:102661275ENST0000055680703427_5230521.0RepeatNote=WD 6
TgeneWDR20chr17:2206927chr14:102661275ENST0000055680703524_5590521.0RepeatNote=WD 7
TgeneWDR20chr17:2206927chr14:102661275ENST000005568070394_1380521.0RepeatNote=WD 1

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSMG6chr17:2206927chr14:102661275ENST00000263073-1191197_1239291420.0Coiled coilOntology_term=ECO:0000255
HgeneSMG6chr17:2206927chr14:102661275ENST00000263073-119163_193291420.0Coiled coilOntology_term=ECO:0000255
HgeneSMG6chr17:2206927chr14:102661275ENST00000263073-119567_625291420.0Coiled coilOntology_term=ECO:0000255
HgeneSMG6chr17:2206927chr14:102661275ENST00000354901-1121197_12390512.0Coiled coilOntology_term=ECO:0000255
HgeneSMG6chr17:2206927chr14:102661275ENST00000354901-112163_1930512.0Coiled coilOntology_term=ECO:0000255
HgeneSMG6chr17:2206927chr14:102661275ENST00000354901-112567_6250512.0Coiled coilOntology_term=ECO:0000255
HgeneSMG6chr17:2206927chr14:102661275ENST00000536871-1111197_12390512.0Coiled coilOntology_term=ECO:0000255
HgeneSMG6chr17:2206927chr14:102661275ENST00000536871-111163_1930512.0Coiled coilOntology_term=ECO:0000255
HgeneSMG6chr17:2206927chr14:102661275ENST00000536871-111567_6250512.0Coiled coilOntology_term=ECO:0000255
HgeneSMG6chr17:2206927chr14:102661275ENST00000544865-1191197_123901389.0Coiled coilOntology_term=ECO:0000255
HgeneSMG6chr17:2206927chr14:102661275ENST00000544865-119163_19301389.0Coiled coilOntology_term=ECO:0000255
HgeneSMG6chr17:2206927chr14:102661275ENST00000544865-119567_62501389.0Coiled coilOntology_term=ECO:0000255
HgeneSMG6chr17:2206927chr14:102661275ENST00000263073-1191246_1397291420.0DomainNote=PINc
HgeneSMG6chr17:2206927chr14:102661275ENST00000354901-1121246_13970512.0DomainNote=PINc
HgeneSMG6chr17:2206927chr14:102661275ENST00000536871-1111246_13970512.0DomainNote=PINc
HgeneSMG6chr17:2206927chr14:102661275ENST00000544865-1191246_139701389.0DomainNote=PINc


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Fusion Gene Sequence for SMG6-WDR20


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>84134_84134_1_SMG6-WDR20_SMG6_chr17_2206927_ENST00000263073_WDR20_chr14_102661275_ENST00000335263_length(transcript)=2426nt_BP=139nt
GCTGCGCGCGGCGGTGGCGGAGCCGCTACGGCTGTAGCAGCAGCCGCGAAGATGGCGGAAGGGCTGGAGCGTGTGCGGATCTCCGCGTCG
GAGCTGCGCGGGATCCTGGCTACTCTGGCCCCGCAGGCCGGGAGCAGAGGCTGCTGACTTGAGTAAACCAATAGATAAAAGGATATACAA
AGGAACACAGCCTACTTGTCATGACTTCAACCACCTAACAGCCACAGCAGAAAGTGTCTCTCTCCTAGTGGGCTTTTCCGCAGGCCAAGT
CCAGCTTATAGACCCAATCAAAAAAGAAACTAGCAAACTTTTTAATGAGGAAAGACTAATAGACAAGTCACGAGTTACCTGTGTCAAATG
GGTTCCCGGTTCGGAAAGCCTTTTCCTAGTAGCCCACTCGAGTGGGAACATGTACTTATATAATGTGGAGCACACTTGTGGCACCACAGC
CCCCCACTACCAGCTTCTGAAGCAGGGAGAGAGCTTTGCCGTGCACACTTGCAAGAGCAAATCCACGAGGAACCCTCTCCTTAAGTGGAC
GGTGGGCGAGGGGGCCCTCAACGAGTTTGCTTTCTCCCCAGATGGCAAGTTCTTAGCGTGCGTGAGCCAGGACGGGTTTCTGCGGGTGTT
CAACTTTGACTCAGTGGAGCTGCACGGTACGATGAAAAGCTACTTTGGGGGCTTGCTGTGTGTGTGCTGGAGCCCGGATGGCAAGTACAT
CGTGACAGGTGGGGAGGACGACTTGGTGACAGTCTGGTCCTTTGTAGACTGCCGAGTAATAGCCAGAGGCCACGGGCACAAGTCCTGGGT
CAGTGTTGTAGCGTTTGACCCTTATACCACTAGTGTAGAAGAAGGTGACCCTATGGAGTTTAGTGGCAGCGATGAGGACTTCCAAGACCT
TCTTCATTTTGGCAGAGATCGAGCAAATAGTACACAGTCCAGGCTCTCCAAACGGAACTCTACAGACAGCCGCCCCGTAAGTGTCACGTA
TCGGTTTGGTTCCGTGGGCCAGGACACACAGCTCTGTTTATGGGACCTTACAGAAGATATCCTTTTCCCTCACCAACCCCTCTCAAGAGC
AAGGACACACACAAATGTCATGAATGCCACGAGTCCTCCTGCTGGAAGCAATGGGAACAGTGTTACAACACCCGGGAACTCTGTGCCGCC
TCCTCTGCCACGGTCCAACAGCCTTCCACATTCAGCAGTCTCAAATGCTGGCAGCAAAAGCAGTGTCATGGACGGGGCCATTGCTTCTGG
GGTCAGCAAATTTGCAACACTTTCACTACATGACCGGAAGGAGAGGCACCACGAGAAAGATCACAAGCGAAATCATAGCATGGGACACAT
TTCTAGCAAGAGCAGTGACAAACTGAATCTAGTTACCAAAACCAAAACGGACCCTGCTAAAACTCTGGGAACGCCCCTGTGTCCTCGAAT
GGAAGATGTTCCCTTGTTAGAGCCGCTGATATGTAAAAAGATAGCACATGAGAGACTGACTGTACTAATATTTCTTGAAGACTGTATAGT
CACTGCTTGTCAGGAGGGATTTATTTGCACATGGGGAAGGCCTGGTAAAGTGGGCTCATTGTCATCCCCAAGCCAGGCCAGTTCTCCAGG
TGGAACTGTAGTGTAGCGACCTCACTGCTGCGCGCACAGTCTCCCGGGACTTGGACTCGAGGGAGTGACGAGGAGGAGCTCCGAGCTGCG
CCTGAGCCGTGCCAGCCGGCGGACCTCAGGCGGTGGACGTCGGCGATAGCCGTGTGGACGGTGACCGGCTCACTCTGCGGCGCCGTGCTC
CCGCTGCTCACCCAAAGAAGTTGTTTCCATTTTAAACCGGTCTTTTGGGGCTGCAGTAAAAAATAAGAAATGGAGTTTTCTTGCTTTTTA
CTCTAAAATTCAATGTAATTAAATTTCATATATATATAATATATACATATATACATAGTGTAAAATAAAATGTTTCTTGGACAAGAAATC
CCCTGAAATTCAGCTGTTATAGTGCTTCACTGTTTTTGCACTGATTTTTCTATACCTTAGGTGGTCAGAAGACAACCTTGAATGCACTCA
TAGAGAAAACTGTTACTTTCTGACGTAATGTAATTCAGGAAGACAGACGCTGCAATCACAGATTTTAAAAAATTGTTTGCACTTAAAAAT
AGTTGAATGCTGGTGGAAAGTTACTTTGCAGATGGGTGTAAGGACTCATGGCCCTCTGAGGTGCGGCGTGAAGATGCCCTTTTTACCCGT
TGACGTTTATTTTACGTAAAATAAACTGTTGTTTCCAATGCAATCAACTCTGTATTATATGTATAAATATTGTAATTCTGCAATTGGGGA
AAATAGTTACTTCACTAGTAATTTTCATCATTTAAGAGTGATATTTCTAATTCACAAAAGTTAATATTAAAACTATCTTGAATATA

>84134_84134_1_SMG6-WDR20_SMG6_chr17_2206927_ENST00000263073_WDR20_chr14_102661275_ENST00000335263_length(amino acids)=495AA_BP=
MSKPIDKRIYKGTQPTCHDFNHLTATAESVSLLVGFSAGQVQLIDPIKKETSKLFNEERLIDKSRVTCVKWVPGSESLFLVAHSSGNMYL
YNVEHTCGTTAPHYQLLKQGESFAVHTCKSKSTRNPLLKWTVGEGALNEFAFSPDGKFLACVSQDGFLRVFNFDSVELHGTMKSYFGGLL
CVCWSPDGKYIVTGGEDDLVTVWSFVDCRVIARGHGHKSWVSVVAFDPYTTSVEEGDPMEFSGSDEDFQDLLHFGRDRANSTQSRLSKRN
STDSRPVSVTYRFGSVGQDTQLCLWDLTEDILFPHQPLSRARTHTNVMNATSPPAGSNGNSVTTPGNSVPPPLPRSNSLPHSAVSNAGSK
SSVMDGAIASGVSKFATLSLHDRKERHHEKDHKRNHSMGHISSKSSDKLNLVTKTKTDPAKTLGTPLCPRMEDVPLLEPLICKKIAHERL
TVLIFLEDCIVTACQEGFICTWGRPGKVGSLSSPSQASSPGGTVV

--------------------------------------------------------------

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Fusion Gene PPI Analysis for SMG6-WDR20


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneSMG6chr17:2206927chr14:102661275ENST00000263073-119114_50329.3333333333333321420.0telomeric DNA
HgeneSMG6chr17:2206927chr14:102661275ENST00000354901-112114_5030512.0telomeric DNA
HgeneSMG6chr17:2206927chr14:102661275ENST00000536871-111114_5030512.0telomeric DNA
HgeneSMG6chr17:2206927chr14:102661275ENST00000544865-119114_50301389.0telomeric DNA


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for SMG6-WDR20


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for SMG6-WDR20


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneC0238463Papillary thyroid carcinoma1CTD_human
TgeneC3501843Nonmedullary Thyroid Carcinoma1CTD_human
TgeneC3501844Familial Nonmedullary Thyroid Cancer1CTD_human