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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ATMIN-IGF2 (FusionGDB2 ID:HG23300TG3481)

Fusion Gene Summary for ATMIN-IGF2

check button Fusion gene summary
Fusion gene informationFusion gene name: ATMIN-IGF2
Fusion gene ID: hg23300tg3481
HgeneTgene
Gene symbol

ATMIN

IGF2

Gene ID

23300

3481

Gene nameATM interactorinsulin like growth factor 2
SynonymsASCIZ|ZNF822C11orf43|GRDF|IGF-II|PP9974
Cytomap('ATMIN')('IGF2')

16q23.2

11p15.5

Type of geneprotein-codingprotein-coding
DescriptionATM interactorATM INteracting proteinATM/ATR-Substrate Chk2-Interacting Zn++-finger proteinATM/ATR-substrate CHEK2-interacting zinc finger proteinATM/ATR-substrate CHK2-interacting zinc finger proteinzinc finger protein 822insulin-like growth factor IIT3M-11-derived growth factorinsulin-like growth factor 2 (somatomedin A)insulin-like growth factor type 2preptin
Modification date2020031520200322
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000299575, ENST00000539819, 
ENST00000564241, ENST00000566488, 
Fusion gene scores* DoF score6 X 5 X 4=12050 X 61 X 13=39650
# samples 637
** MAII scorelog2(6/120*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(37/39650*10)=-6.74365178496239
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ATMIN [Title/Abstract] AND IGF2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointATMIN(81069598)-IGF2(2150764), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneATMIN

GO:0045893

positive regulation of transcription, DNA-templated

22167198

TgeneIGF2

GO:0008284

positive regulation of cell proliferation

28873464

TgeneIGF2

GO:0042104

positive regulation of activated T cell proliferation

15694994

TgeneIGF2

GO:0043410

positive regulation of MAPK cascade

11500939

TgeneIGF2

GO:0045840

positive regulation of mitotic nuclear division

11500939

TgeneIGF2

GO:0046628

positive regulation of insulin receptor signaling pathway

11500939

TgeneIGF2

GO:0051897

positive regulation of protein kinase B signaling

11500939



check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4KIRPTCGA-J7-A8I2ATMINchr16

81069598

+IGF2chr11

2150764

-


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Fusion Gene ORF analysis for ATMIN-IGF2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000299575ENST00000300632ATMINchr16

81069598

+IGF2chr11

2150764

-
5CDS-3UTRENST00000299575ENST00000381395ATMINchr16

81069598

+IGF2chr11

2150764

-
5CDS-3UTRENST00000299575ENST00000381406ATMINchr16

81069598

+IGF2chr11

2150764

-
5CDS-3UTRENST00000299575ENST00000416167ATMINchr16

81069598

+IGF2chr11

2150764

-
5CDS-intronENST00000299575ENST00000381389ATMINchr16

81069598

+IGF2chr11

2150764

-
5CDS-intronENST00000299575ENST00000381392ATMINchr16

81069598

+IGF2chr11

2150764

-
5CDS-intronENST00000299575ENST00000418738ATMINchr16

81069598

+IGF2chr11

2150764

-
5CDS-intronENST00000299575ENST00000434045ATMINchr16

81069598

+IGF2chr11

2150764

-
intron-3UTRENST00000539819ENST00000300632ATMINchr16

81069598

+IGF2chr11

2150764

-
intron-3UTRENST00000539819ENST00000381395ATMINchr16

81069598

+IGF2chr11

2150764

-
intron-3UTRENST00000539819ENST00000381406ATMINchr16

81069598

+IGF2chr11

2150764

-
intron-3UTRENST00000539819ENST00000416167ATMINchr16

81069598

+IGF2chr11

2150764

-
intron-3UTRENST00000564241ENST00000300632ATMINchr16

81069598

+IGF2chr11

2150764

-
intron-3UTRENST00000564241ENST00000381395ATMINchr16

81069598

+IGF2chr11

2150764

-
intron-3UTRENST00000564241ENST00000381406ATMINchr16

81069598

+IGF2chr11

2150764

-
intron-3UTRENST00000564241ENST00000416167ATMINchr16

81069598

+IGF2chr11

2150764

-
intron-3UTRENST00000566488ENST00000300632ATMINchr16

81069598

+IGF2chr11

2150764

-
intron-3UTRENST00000566488ENST00000381395ATMINchr16

81069598

+IGF2chr11

2150764

-
intron-3UTRENST00000566488ENST00000381406ATMINchr16

81069598

+IGF2chr11

2150764

-
intron-3UTRENST00000566488ENST00000416167ATMINchr16

81069598

+IGF2chr11

2150764

-
intron-intronENST00000539819ENST00000381389ATMINchr16

81069598

+IGF2chr11

2150764

-
intron-intronENST00000539819ENST00000381392ATMINchr16

81069598

+IGF2chr11

2150764

-
intron-intronENST00000539819ENST00000418738ATMINchr16

81069598

+IGF2chr11

2150764

-
intron-intronENST00000539819ENST00000434045ATMINchr16

81069598

+IGF2chr11

2150764

-
intron-intronENST00000564241ENST00000381389ATMINchr16

81069598

+IGF2chr11

2150764

-
intron-intronENST00000564241ENST00000381392ATMINchr16

81069598

+IGF2chr11

2150764

-
intron-intronENST00000564241ENST00000418738ATMINchr16

81069598

+IGF2chr11

2150764

-
intron-intronENST00000564241ENST00000434045ATMINchr16

81069598

+IGF2chr11

2150764

-
intron-intronENST00000566488ENST00000381389ATMINchr16

81069598

+IGF2chr11

2150764

-
intron-intronENST00000566488ENST00000381392ATMINchr16

81069598

+IGF2chr11

2150764

-
intron-intronENST00000566488ENST00000418738ATMINchr16

81069598

+IGF2chr11

2150764

-
intron-intronENST00000566488ENST00000434045ATMINchr16

81069598

+IGF2chr11

2150764

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for ATMIN-IGF2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)


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Fusion Protein Features for ATMIN-IGF2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:81069598/:2150764)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for ATMIN-IGF2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for ATMIN-IGF2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ATMIN-IGF2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ATMIN-IGF2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneC0004903Beckwith-Wiedemann Syndrome4CTD_human;GENOMICS_ENGLAND
TgeneC0015934Fetal Growth Retardation3CTD_human;GENOMICS_ENGLAND
TgeneC0036341Schizophrenia2PSYGENET
TgeneC0175693Russell-Silver syndrome2CTD_human;GENOMICS_ENGLAND
TgeneC0206686Adrenocortical carcinoma2CTD_human
TgeneC2239176Liver carcinoma2CTD_human
TgeneC0000786Spontaneous abortion1CTD_human
TgeneC0000822Abortion, Tubal1CTD_human
TgeneC0002395Alzheimer's Disease1CTD_human
TgeneC0002871Anemia1CTD_human
TgeneC0004153Atherosclerosis1CTD_human
TgeneC0004352Autistic Disorder1CTD_human
TgeneC0005941Bone Diseases, Developmental1CTD_human
TgeneC0007102Malignant tumor of colon1CTD_human
TgeneC0009241Cognition Disorders1CTD_human
TgeneC0009375Colonic Neoplasms1CTD_human
TgeneC0009402Colorectal Carcinoma1CTD_human
TgeneC0009404Colorectal Neoplasms1CTD_human
TgeneC0011265Presenile dementia1CTD_human
TgeneC0018273Growth Disorders1CTD_human
TgeneC0019284Diaphragmatic Hernia1CTD_human
TgeneC0020224Polyhydramnios1CTD_human
TgeneC0020615Hypoglycemia1CTD_human
TgeneC0023903Liver neoplasms1CTD_human
TgeneC0025261Memory Disorders1CTD_human
TgeneC0027708Nephroblastoma1CTD_human
TgeneC0027746Nerve Degeneration1CTD_human
TgeneC0028754Obesity1CTD_human
TgeneC0030567Parkinson Disease1CTD_human
TgeneC0032045Placenta Disorders1CTD_human
TgeneC0032927Precancerous Conditions1CTD_human
TgeneC0035412Rhabdomyosarcoma1CTD_human
TgeneC0206624Hepatoblastoma1CTD_human
TgeneC0233794Memory impairment1CTD_human
TgeneC0271708Fasting Hypoglycemia1CTD_human
TgeneC0271710Reactive hypoglycemia1CTD_human
TgeneC0276496Familial Alzheimer Disease (FAD)1CTD_human
TgeneC0282313Condition, Preneoplastic1CTD_human
TgeneC0332890Congenital hemihypertrophy1ORPHANET
TgeneC0345904Malignant neoplasm of liver1CTD_human
TgeneC0473935Radiolabeled somatostatin analog study1GENOMICS_ENGLAND
TgeneC0494463Alzheimer Disease, Late Onset1CTD_human
TgeneC0546126Acute Confusional Senile Dementia1CTD_human
TgeneC0678807prenatal alcohol exposure1PSYGENET
TgeneC0750900Alzheimer's Disease, Focal Onset1CTD_human
TgeneC0750901Alzheimer Disease, Early Onset1CTD_human
TgeneC0751292Age-Related Memory Disorders1CTD_human
TgeneC0751293Memory Disorder, Semantic1CTD_human
TgeneC0751294Memory Disorder, Spatial1CTD_human
TgeneC0751295Memory Loss1CTD_human
TgeneC0752347Lewy Body Disease1CTD_human
TgeneC0796160MENTAL RETARDATION, X-LINKED, SNYDER-ROBINSON TYPE1GENOMICS_ENGLAND
TgeneC1563937Atherogenesis1CTD_human
TgeneC1855652Fetus Small for Gestational Age1GENOMICS_ENGLAND
TgeneC1856184HEMIHYPERPLASIA, ISOLATED1ORPHANET
TgeneC2930471Bilateral Wilms Tumor1CTD_human
TgeneC3830362Early Pregnancy Loss1CTD_human
TgeneC4225307GROWTH RESTRICTION, SEVERE, WITH DISTINCTIVE FACIES1CTD_human;GENOMICS_ENGLAND
TgeneC4552766Miscarriage1CTD_human