Fusion Gene Studies
in Kim Lab

FusionBase FusionGDB FusionGDB2 FusionPDB FusionNeoAntigen FusionAI FusionNW FGviewer Publication Contact
FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:DOCK9-STK24 (FusionGDB2 ID:HG23348TG8428)

Fusion Gene Summary for DOCK9-STK24

check button Fusion gene summary
Fusion gene informationFusion gene name: DOCK9-STK24
Fusion gene ID: hg23348tg8428
HgeneTgene
Gene symbol

DOCK9

STK24

Gene ID

23348

8428

Gene namededicator of cytokinesis 9serine/threonine kinase 24
SynonymsZIZ1|ZIZIMIN1HEL-S-95|MST3|MST3B|STE20|STK3
Cytomap('DOCK9')('STK24')

13q32.3

13q32.2

Type of geneprotein-codingprotein-coding
Descriptiondedicator of cytokinesis protein 9cdc42 guanine nucleotide exchange factor zizimin-1serine/threonine-protein kinase 24STE20-like kinase 3STE20-like kinase MST3epididymis secretory protein Li 95mammalian STE20-like protein kinase 3serine/threonine kinase 24 (STE20 homolog, yeast)sterile 20-like kinase 3
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000339416, ENST00000376460, 
ENST00000442173, ENST00000448493, 
ENST00000461998, 		ENST00000448493, 
ENST00000442173, ENST00000461998, 
ENST00000339416, ENST00000376460, 
Fusion gene scores* DoF score13 X 11 X 7=100115 X 8 X 8=960
# samples 1518
** MAII scorelog2(15/1001*10)=-2.73840756834011
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(18/960*10)=-2.41503749927884
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: DOCK9 [Title/Abstract] AND STK24 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointDOCK9(99607689)-STK24(99134575), # samples:1
Anticipated loss of major functional domain due to fusion event.DOCK9-STK24 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
DOCK9-STK24 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
DOCK9-STK24 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
DOCK9-STK24 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
STK24-DOCK9 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
STK24-DOCK9 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
STK24-DOCK9 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
STK24-DOCK9 seems lost the major protein functional domain in Hgene partner, which is a kinase due to the frame-shifted ORF.
STK24-DOCK9 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneSTK24

GO:0006468

protein phosphorylation

19604147

TgeneSTK24

GO:0042542

response to hydrogen peroxide

22291017

TgeneSTK24

GO:0046777

protein autophosphorylation

17046825|17657516


check buttonFusion gene breakpoints across DOCK9 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across STK24 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUSCTCGA-34-A5IXDOCK9chr13

99607689

-STK24chr13

99134575

-


Top

Fusion Gene ORF analysis for DOCK9-STK24

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000339416ENST00000376547DOCK9chr13

99607689

-STK24chr13

99134575

-
5CDS-intronENST00000339416ENST00000481288DOCK9chr13

99607689

-STK24chr13

99134575

-
5CDS-intronENST00000339416ENST00000539966DOCK9chr13

99607689

-STK24chr13

99134575

-
5CDS-intronENST00000376460ENST00000376547DOCK9chr13

99607689

-STK24chr13

99134575

-
5CDS-intronENST00000376460ENST00000481288DOCK9chr13

99607689

-STK24chr13

99134575

-
5CDS-intronENST00000376460ENST00000539966DOCK9chr13

99607689

-STK24chr13

99134575

-
5CDS-intronENST00000442173ENST00000376547DOCK9chr13

99607689

-STK24chr13

99134575

-
5CDS-intronENST00000442173ENST00000481288DOCK9chr13

99607689

-STK24chr13

99134575

-
5CDS-intronENST00000442173ENST00000539966DOCK9chr13

99607689

-STK24chr13

99134575

-
5CDS-intronENST00000448493ENST00000376547DOCK9chr13

99607689

-STK24chr13

99134575

-
5CDS-intronENST00000448493ENST00000481288DOCK9chr13

99607689

-STK24chr13

99134575

-
5CDS-intronENST00000448493ENST00000539966DOCK9chr13

99607689

-STK24chr13

99134575

-
In-frameENST00000339416ENST00000397517DOCK9chr13

99607689

-STK24chr13

99134575

-
In-frameENST00000376460ENST00000397517DOCK9chr13

99607689

-STK24chr13

99134575

-
In-frameENST00000442173ENST00000397517DOCK9chr13

99607689

-STK24chr13

99134575

-
In-frameENST00000448493ENST00000397517DOCK9chr13

99607689

-STK24chr13

99134575

-
intron-3CDSENST00000461998ENST00000397517DOCK9chr13

99607689

-STK24chr13

99134575

-
intron-intronENST00000461998ENST00000376547DOCK9chr13

99607689

-STK24chr13

99134575

-
intron-intronENST00000461998ENST00000481288DOCK9chr13

99607689

-STK24chr13

99134575

-
intron-intronENST00000461998ENST00000539966DOCK9chr13

99607689

-STK24chr13

99134575

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000376460DOCK9chr1399607689-ENST00000397517STK24chr1399134575-431932401346448
ENST00000339416DOCK9chr1399607689-ENST00000397517STK24chr1399134575-4296301551323422
ENST00000448493DOCK9chr1399607689-ENST00000397517STK24chr1399134575-438539061412468
ENST00000442173DOCK9chr1399607689-ENST00000397517STK24chr1399134575-4413418251440471

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000376460ENST00000397517DOCK9chr1399607689-STK24chr1399134575-0.0007659260.9992341
ENST00000339416ENST00000397517DOCK9chr1399607689-STK24chr1399134575-0.0012635960.99873644
ENST00000448493ENST00000397517DOCK9chr1399607689-STK24chr1399134575-0.0010009790.99899906
ENST00000442173ENST00000397517DOCK9chr1399607689-STK24chr1399134575-0.0007773270.99922264

Top

Fusion Genomic Features for DOCK9-STK24


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

Top

Fusion Protein Features for DOCK9-STK24


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr13:99607689/chr13:99134575)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneSTK24chr13:99607689chr13:99134575ENST00000376547111278_292103444.0MotifNote=Bipartite nuclear localization signal
TgeneSTK24chr13:99607689chr13:99134575ENST00000376547111335_386103444.0MotifNote=Nuclear export signal (NES)
TgeneSTK24chr13:99607689chr13:99134575ENST00000397517111278_29291432.0MotifNote=Bipartite nuclear localization signal
TgeneSTK24chr13:99607689chr13:99134575ENST00000397517111335_38691432.0MotifNote=Nuclear export signal (NES)
TgeneSTK24chr13:99607689chr13:99134575ENST00000376547111112_114103444.0Nucleotide bindingNote=ATP
TgeneSTK24chr13:99607689chr13:99134575ENST00000397517111112_11491432.0Nucleotide bindingNote=ATP

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneDOCK9chr13:99607689chr13:99134575ENST00000339416-2541948_1982822094.0Coiled coilOntology_term=ECO:0000255
HgeneDOCK9chr13:99607689chr13:99134575ENST00000339416-2542034_2067822094.0Coiled coilOntology_term=ECO:0000255
HgeneDOCK9chr13:99607689chr13:99134575ENST00000376460-2571948_1982812069.0Coiled coilOntology_term=ECO:0000255
HgeneDOCK9chr13:99607689chr13:99134575ENST00000376460-2572034_2067812069.0Coiled coilOntology_term=ECO:0000255
HgeneDOCK9chr13:99607689chr13:99134575ENST00000442173-2331948_1982811254.0Coiled coilOntology_term=ECO:0000255
HgeneDOCK9chr13:99607689chr13:99134575ENST00000442173-2332034_2067811254.0Coiled coilOntology_term=ECO:0000255
HgeneDOCK9chr13:99607689chr13:99134575ENST00000339416-2541605_2069822094.0DomainDOCKER
HgeneDOCK9chr13:99607689chr13:99134575ENST00000339416-254174_281822094.0DomainPH
HgeneDOCK9chr13:99607689chr13:99134575ENST00000339416-254640_818822094.0DomainC2 DOCK-type
HgeneDOCK9chr13:99607689chr13:99134575ENST00000376460-2571605_2069812069.0DomainDOCKER
HgeneDOCK9chr13:99607689chr13:99134575ENST00000376460-257174_281812069.0DomainPH
HgeneDOCK9chr13:99607689chr13:99134575ENST00000376460-257640_818812069.0DomainC2 DOCK-type
HgeneDOCK9chr13:99607689chr13:99134575ENST00000442173-2331605_2069811254.0DomainDOCKER
HgeneDOCK9chr13:99607689chr13:99134575ENST00000442173-233174_281811254.0DomainPH
HgeneDOCK9chr13:99607689chr13:99134575ENST00000442173-233640_818811254.0DomainC2 DOCK-type
TgeneSTK24chr13:99607689chr13:99134575ENST0000037654711136_286103444.0DomainProtein kinase
TgeneSTK24chr13:99607689chr13:99134575ENST0000039751711136_28691432.0DomainProtein kinase
TgeneSTK24chr13:99607689chr13:99134575ENST0000037654711142_50103444.0Nucleotide bindingNote=ATP
TgeneSTK24chr13:99607689chr13:99134575ENST0000039751711142_5091432.0Nucleotide bindingNote=ATP


Top

Fusion Gene Sequence for DOCK9-STK24


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>23852_23852_1_DOCK9-STK24_DOCK9_chr13_99607689_ENST00000339416_STK24_chr13_99134575_ENST00000397517_length(transcript)=4296nt_BP=301nt
GCGGCCGGGCCGGGCCGCGGGAGCAGGCGGAGGCGGAGGCGGCGGGGGCAGGAGGATGTCGCAGCCGCCGCTGCTCCCCGCCTCGGCGGA
GACTCGGAAGTTCACCCGGGCGCTGAGTAAGCCGGGCACGGCGGCCGAGCTGCGGCAGAGCGTGTCTGAGGTGGTGCGCGGCTCCGTGCT
CCTGGCAAAGCCAAAGCTAATTGAGCCACTCGACTATGAAAATGTCATCGTCCAGAAGAAGACTCAGATCCTGAACGACTGTTTACGGGA
GATGCTGCTCTTCCCTTACGATGACTTTCAGGATACAAAATTATGGATAATAATGGAATATCTTGGTGGAGGCTCCGCACTAGATCTATT
AGAACCTGGCCCATTAGATGAAACCCAGATCGCTACTATATTAAGAGAAATACTGAAAGGACTCGATTATCTCCATTCGGAGAAGAAAAT
CCACAGAGACATTAAAGCGGCCAACGTCCTGCTGTCTGAGCATGGCGAGGTGAAGCTGGCGGACTTTGGCGTGGCTGGCCAGCTGACAGA
CACCCAGATCAAAAGGAACACCTTCGTGGGCACCCCATTCTGGATGGCACCCGAGGTCATCAAACAGTCGGCCTATGACTCGAAGGCAGA
CATCTGGTCCCTGGGCATAACAGCTATTGAACTTGCAAGAGGGGAACCACCTCATTCCGAGCTGCACCCCATGAAAGTTTTATTCCTCAT
TCCAAAGAACAACCCACCGACGTTGGAAGGAAACTACAGTAAACCCCTCAAGGAGTTTGTGGAGGCCTGTTTGAATAAGGAGCCGAGCTT
TAGACCCACTGCTAAGGAGTTATTGAAGCACAAGTTTATACTACGCAATGCAAAGAAAACTTCCTACTTGACCGAGCTCATCGACAGGTA
CAAGAGATGGAAGGCCGAGCAGAGCCATGACGACTCGAGCTCCGAGGATTCCGACGCGGAAACAGATGGCCAAGCCTCGGGGGGCAGTGA
TTCTGGGGACTGGATCTTCACAATCCGAGAAAAAGATCCCAAGAATCTCGAGAATGGAGCTCTTCAGCCATCGGACTTGGACAGAAATAA
GATGAAAGACATCCCGAAGAGGCCTTTCTCTCAGTGTTTATCTACAATTATTTCTCCTCTGTTTGCAGAGTTGAAGGAGAAGAGCCAGGC
GTGCGGAGGGAACTTGGGGTCCATTGAAGAGCTGCGAGGGGCCATCTACCTAGCGGAGGAGGCGTGCCCTGGCATCTCCGACACCATGGT
GGCCCAGCTCGTGCAGCGGCTCCAGAGATACTCTCTAAGTGGTGGAGGAACTTCATCCCACTGAAATTCCTTTGGCATTTGGGGTTTTGT
TTTTCCTTTTTTCCTTCTTCATCCTCCTCCTTTTTTAAAAGTCAACGAGAGCCTTCGCTGACTCCACCGAAGAGGTGCGCCACTGGGAGC
CACCCCAGCGCCAGGCGCCCGTCCAGGGACACACACAGTCTTCACTGTGCTGCAGCCAGATGAAGTCTCTCAGATGGGTGGGGAGGGTCA
GCTCCTTCCAGCGATCATTTTATTTTATTTTATTACTTTTGTTTTTAATTTTAACCATAGTGCACATATTCCAGGAAAGTGTCTTTAAAA
ACAAAAACAAACCCTGAAATGTATATTTGGGATTATGATAAGGCAACTAAAGACATGAAACCTCAGGTATCCTGCTTTAAGTTGATAACT
CCCTCTGGGAGCTGGAGAATCGCTCTGGTGGATGGGTGTACAGATTTGTATATAATGTCATTTTTACGGAAACCCTTTCGGCGTGCATAA
GGAATCACTGTGTACAAACTGGCCAAGTGCTTCTGTAGATAACGTCAGTGGAGTAAATATTCGACAGGCCATAACTTGAGTCTATTGCCT
TGCCTTTATTACATGTACATTTTGAATTCTGTGACCAGTGATTTGGGTTTTATTTTGTATTTGCAGGGTTTGTCATTAATAATTAATGCC
CCTCTCTTACAGAACACTCCTATTTGTACCTCAACAAATGCAAATTTTCCCCGTTTGCCCTACGCCCCTTTTGGTACACCTAGAGGTTGA
TTTCCTTTTTCATCGATGGTACTATTTCTTAGTGTTTTAAATTGGAACATATCTTGCCTCATGAAGCTTTAAATTATAATTTTCAGTTTC
TCCCCATGAAGCGCTCTCGTCTGACATTTGTTTGGAATCGTGCCACTGCTGGTCTGCGCCAGATGTACCGTCCTTTCCAATACGATTTTC
TGTTGCACCTTGTAGTGGATTCTGCATATCATCTTTCCCACCTAAAAATGTCTGAATGCTTACACAAATAAATTTTATAACACGCTTATT
TTGCATACTCCTTGAAATGTGACTCTTCAGAGGACAGGGCACCTGCTGTGTATGTGTGGCCGTGCGTGTGTACTCGTGGCTGTGTGTGTG
TGATGAGACACTTTGGAAGACTCCAGGGAGAAGTCCCCAGGCCTGGAGCTGCCGAGTGCCCAGGTCAGCGCCCTGGACTGCTTGCGCACT
TGCTCACCGAGATGATGCAGTTGGAGGTTGCTGATCTGTGCGATTGCTGTAGCGGTTGCCGGGGACCTTAAGAGTTATTTTGCTTCTCTG
GAAGGGGCCTATGCTTGCTAGGCAGGCAGCCAGTGTGTCTGTTTTTCTTGGTTTGCTGTGGGACCTTGCTTGGCGAGGGGGAAAATCTCT
GGGTTTCTGGAGTGGGAGGGTTCGTGCAGCAGCTGTTGACTGGTACATGAAGCATTCTTTTATGTTTGTTGAAGCTGATGATTGACATCT
CCCGTGGGTGTGCCAGTTCTTGTGGAGTTAAGACAGGATTTTTGGAAGCAAGGAAGTTAGTGGGTGAGCTTGGGGATGTAGCTCAGCTAT
CTGCTGGTCTAGTGGCCTCTAAGCTATAGGGAGGGGACAGAGCCCTGAGCTACAGATGCTTGAGTGGGTTATTGTGTCGGTTTGCTAGTG
CAGTCTGGTTTTTAAGCTCTAAAATTGAGGTATTTTATTAGAAGTGGATTTGGGTTGAACTCTTAATTTGTATAAGGGATATATTTTGGT
TGGGGAAATAGAACTGAGTTGCTAATTCTTATTGTACTCATTACTCCATACAAGAATGTTATGTTGAATAATAAAATTGGAGAAGATTTC
ATTTTGTGTTTCCAGGGAGTATTCTGTGTGGGGAACTGTTTCCTTACGTGAGGCCGGCGGCATAAGTCAAAGATGAGTTTTGTCCTTGCG
AATCACACAGATTGAGTCTGTGTTCCCCAGGGTGTGCCGTTACCTGATTTTTAAGTGAGCCAGGGCGGACAGCAGCTTTTCTGATTTACA
GAGTTCTTCAGATTTACAAATGGACAATGACATCACAGTTTTTAGCACTGAAGCCAGTCTCATGCTAGTAACAGTGGGTGAGCCGCTCGA
GGGACTGGGTTCTAATGAATACTGGTATGAACGGGGAGTCTCTGCAGTCGCCAGACAAATCATACTCAGCCCCTTCCCCCGTAGAGCAAC
AAGTGGTTCTTTTAGAGTTGACTGGCAGCATTTCCTGTCGGGGGAGGTGGGGTTTGATGGAGTTAGAAAGCTCGCCTCTGTGTACATTCT
CTCCTGGGCTGTTACTTTCTGTAGACGCACAAAATCAGCCCCAATGTTTTTAAGGGCATCTTAGCCAAGGAAGCTGGCTTTTGTGTCGCC
ACTTCCAGGCCTGCATTAAGAGAGAGCCCAGGCACCAGGGCTACCACTGGAACCTGCCTCAGCGTCAACTGCTGCTGGTCTGTAGCCAGG
CCCAGCCTTTGAGACGGGTTTACTGTCACCAGTAGCCTCTCAGTGCCAGCCCTGAGCTGCTCCTGGCTCAGCTGCCCAGAGCCTGCAGCC
TGGGGAGGTACTCAGCCTCTGGGAGACGAGGGCCGTGGACTGGGTGGCTGGTAGCTCCTGCGTTTTTGAGCTGTGTCCTGGCTGGCTGCT
GCCAATGAGGTGGACACCAGTGTGGTTTGGGGTGCACTGGCCACTTCTTGCTGGGTTCTGATTTTCTTGGAAGTGCATCTGCCTTCCTTA
TCCAATAGTTTTATCCCTGCATTGCTCTTGTGAAGTGGCTGGTTTGGTTCTGTATGTAGCATTTTGTACCTTTCCTCTGGCAAAACACTG
TCAGTTTATAAACATTTTTTATATTTCCCTCCTTTAAAAACAGCTTGTGTATTTCTGCTATAAAATGTGTCAGCAAAGGCAGAGTGACCT

>23852_23852_1_DOCK9-STK24_DOCK9_chr13_99607689_ENST00000339416_STK24_chr13_99134575_ENST00000397517_length(amino acids)=422AA_BP=0
MSQPPLLPASAETRKFTRALSKPGTAAELRQSVSEVVRGSVLLAKPKLIEPLDYENVIVQKKTQILNDCLREMLLFPYDDFQDTKLWIIM
EYLGGGSALDLLEPGPLDETQIATILREILKGLDYLHSEKKIHRDIKAANVLLSEHGEVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPE
VIKQSAYDSKADIWSLGITAIELARGEPPHSELHPMKVLFLIPKNNPPTLEGNYSKPLKEFVEACLNKEPSFRPTAKELLKHKFILRNAK
KTSYLTELIDRYKRWKAEQSHDDSSSEDSDAETDGQASGGSDSGDWIFTIREKDPKNLENGALQPSDLDRNKMKDIPKRPFSQCLSTIIS

--------------------------------------------------------------
>23852_23852_2_DOCK9-STK24_DOCK9_chr13_99607689_ENST00000376460_STK24_chr13_99134575_ENST00000397517_length(transcript)=4319nt_BP=324nt
CTGGCATGCCTGTGCCTTGCACGGCCAGGGACTCGCAGCTGTTCCAGTTGCAGACTTTCTGACTTGCGTTTTCAGCCGAGAATGCAGGCT
GATAAATGCAGGACAAGTAGTAGAAGTGTCAAAAAGGAACTGGTGATTGAGTCCCCCCTGCAATACAAGGATGCAGCTCAGGGCGAAGTG
GAAGCAGAGAGCCCGGGCCCTGTGCCGGCAAAGCCAAAGCTAATTGAGCCACTCGACTATGAAAATGTCATCGTCCAGAAGAAGACTCAG
ATCCTGAACGACTGTTTACGGGAGATGCTGCTCTTCCCTTACGATGACTTTCAGGATACAAAATTATGGATAATAATGGAATATCTTGGT
GGAGGCTCCGCACTAGATCTATTAGAACCTGGCCCATTAGATGAAACCCAGATCGCTACTATATTAAGAGAAATACTGAAAGGACTCGAT
TATCTCCATTCGGAGAAGAAAATCCACAGAGACATTAAAGCGGCCAACGTCCTGCTGTCTGAGCATGGCGAGGTGAAGCTGGCGGACTTT
GGCGTGGCTGGCCAGCTGACAGACACCCAGATCAAAAGGAACACCTTCGTGGGCACCCCATTCTGGATGGCACCCGAGGTCATCAAACAG
TCGGCCTATGACTCGAAGGCAGACATCTGGTCCCTGGGCATAACAGCTATTGAACTTGCAAGAGGGGAACCACCTCATTCCGAGCTGCAC
CCCATGAAAGTTTTATTCCTCATTCCAAAGAACAACCCACCGACGTTGGAAGGAAACTACAGTAAACCCCTCAAGGAGTTTGTGGAGGCC
TGTTTGAATAAGGAGCCGAGCTTTAGACCCACTGCTAAGGAGTTATTGAAGCACAAGTTTATACTACGCAATGCAAAGAAAACTTCCTAC
TTGACCGAGCTCATCGACAGGTACAAGAGATGGAAGGCCGAGCAGAGCCATGACGACTCGAGCTCCGAGGATTCCGACGCGGAAACAGAT
GGCCAAGCCTCGGGGGGCAGTGATTCTGGGGACTGGATCTTCACAATCCGAGAAAAAGATCCCAAGAATCTCGAGAATGGAGCTCTTCAG
CCATCGGACTTGGACAGAAATAAGATGAAAGACATCCCGAAGAGGCCTTTCTCTCAGTGTTTATCTACAATTATTTCTCCTCTGTTTGCA
GAGTTGAAGGAGAAGAGCCAGGCGTGCGGAGGGAACTTGGGGTCCATTGAAGAGCTGCGAGGGGCCATCTACCTAGCGGAGGAGGCGTGC
CCTGGCATCTCCGACACCATGGTGGCCCAGCTCGTGCAGCGGCTCCAGAGATACTCTCTAAGTGGTGGAGGAACTTCATCCCACTGAAAT
TCCTTTGGCATTTGGGGTTTTGTTTTTCCTTTTTTCCTTCTTCATCCTCCTCCTTTTTTAAAAGTCAACGAGAGCCTTCGCTGACTCCAC
CGAAGAGGTGCGCCACTGGGAGCCACCCCAGCGCCAGGCGCCCGTCCAGGGACACACACAGTCTTCACTGTGCTGCAGCCAGATGAAGTC
TCTCAGATGGGTGGGGAGGGTCAGCTCCTTCCAGCGATCATTTTATTTTATTTTATTACTTTTGTTTTTAATTTTAACCATAGTGCACAT
ATTCCAGGAAAGTGTCTTTAAAAACAAAAACAAACCCTGAAATGTATATTTGGGATTATGATAAGGCAACTAAAGACATGAAACCTCAGG
TATCCTGCTTTAAGTTGATAACTCCCTCTGGGAGCTGGAGAATCGCTCTGGTGGATGGGTGTACAGATTTGTATATAATGTCATTTTTAC
GGAAACCCTTTCGGCGTGCATAAGGAATCACTGTGTACAAACTGGCCAAGTGCTTCTGTAGATAACGTCAGTGGAGTAAATATTCGACAG
GCCATAACTTGAGTCTATTGCCTTGCCTTTATTACATGTACATTTTGAATTCTGTGACCAGTGATTTGGGTTTTATTTTGTATTTGCAGG
GTTTGTCATTAATAATTAATGCCCCTCTCTTACAGAACACTCCTATTTGTACCTCAACAAATGCAAATTTTCCCCGTTTGCCCTACGCCC
CTTTTGGTACACCTAGAGGTTGATTTCCTTTTTCATCGATGGTACTATTTCTTAGTGTTTTAAATTGGAACATATCTTGCCTCATGAAGC
TTTAAATTATAATTTTCAGTTTCTCCCCATGAAGCGCTCTCGTCTGACATTTGTTTGGAATCGTGCCACTGCTGGTCTGCGCCAGATGTA
CCGTCCTTTCCAATACGATTTTCTGTTGCACCTTGTAGTGGATTCTGCATATCATCTTTCCCACCTAAAAATGTCTGAATGCTTACACAA
ATAAATTTTATAACACGCTTATTTTGCATACTCCTTGAAATGTGACTCTTCAGAGGACAGGGCACCTGCTGTGTATGTGTGGCCGTGCGT
GTGTACTCGTGGCTGTGTGTGTGTGATGAGACACTTTGGAAGACTCCAGGGAGAAGTCCCCAGGCCTGGAGCTGCCGAGTGCCCAGGTCA
GCGCCCTGGACTGCTTGCGCACTTGCTCACCGAGATGATGCAGTTGGAGGTTGCTGATCTGTGCGATTGCTGTAGCGGTTGCCGGGGACC
TTAAGAGTTATTTTGCTTCTCTGGAAGGGGCCTATGCTTGCTAGGCAGGCAGCCAGTGTGTCTGTTTTTCTTGGTTTGCTGTGGGACCTT
GCTTGGCGAGGGGGAAAATCTCTGGGTTTCTGGAGTGGGAGGGTTCGTGCAGCAGCTGTTGACTGGTACATGAAGCATTCTTTTATGTTT
GTTGAAGCTGATGATTGACATCTCCCGTGGGTGTGCCAGTTCTTGTGGAGTTAAGACAGGATTTTTGGAAGCAAGGAAGTTAGTGGGTGA
GCTTGGGGATGTAGCTCAGCTATCTGCTGGTCTAGTGGCCTCTAAGCTATAGGGAGGGGACAGAGCCCTGAGCTACAGATGCTTGAGTGG
GTTATTGTGTCGGTTTGCTAGTGCAGTCTGGTTTTTAAGCTCTAAAATTGAGGTATTTTATTAGAAGTGGATTTGGGTTGAACTCTTAAT
TTGTATAAGGGATATATTTTGGTTGGGGAAATAGAACTGAGTTGCTAATTCTTATTGTACTCATTACTCCATACAAGAATGTTATGTTGA
ATAATAAAATTGGAGAAGATTTCATTTTGTGTTTCCAGGGAGTATTCTGTGTGGGGAACTGTTTCCTTACGTGAGGCCGGCGGCATAAGT
CAAAGATGAGTTTTGTCCTTGCGAATCACACAGATTGAGTCTGTGTTCCCCAGGGTGTGCCGTTACCTGATTTTTAAGTGAGCCAGGGCG
GACAGCAGCTTTTCTGATTTACAGAGTTCTTCAGATTTACAAATGGACAATGACATCACAGTTTTTAGCACTGAAGCCAGTCTCATGCTA
GTAACAGTGGGTGAGCCGCTCGAGGGACTGGGTTCTAATGAATACTGGTATGAACGGGGAGTCTCTGCAGTCGCCAGACAAATCATACTC
AGCCCCTTCCCCCGTAGAGCAACAAGTGGTTCTTTTAGAGTTGACTGGCAGCATTTCCTGTCGGGGGAGGTGGGGTTTGATGGAGTTAGA
AAGCTCGCCTCTGTGTACATTCTCTCCTGGGCTGTTACTTTCTGTAGACGCACAAAATCAGCCCCAATGTTTTTAAGGGCATCTTAGCCA
AGGAAGCTGGCTTTTGTGTCGCCACTTCCAGGCCTGCATTAAGAGAGAGCCCAGGCACCAGGGCTACCACTGGAACCTGCCTCAGCGTCA
ACTGCTGCTGGTCTGTAGCCAGGCCCAGCCTTTGAGACGGGTTTACTGTCACCAGTAGCCTCTCAGTGCCAGCCCTGAGCTGCTCCTGGC
TCAGCTGCCCAGAGCCTGCAGCCTGGGGAGGTACTCAGCCTCTGGGAGACGAGGGCCGTGGACTGGGTGGCTGGTAGCTCCTGCGTTTTT
GAGCTGTGTCCTGGCTGGCTGCTGCCAATGAGGTGGACACCAGTGTGGTTTGGGGTGCACTGGCCACTTCTTGCTGGGTTCTGATTTTCT
TGGAAGTGCATCTGCCTTCCTTATCCAATAGTTTTATCCCTGCATTGCTCTTGTGAAGTGGCTGGTTTGGTTCTGTATGTAGCATTTTGT
ACCTTTCCTCTGGCAAAACACTGTCAGTTTATAAACATTTTTTATATTTCCCTCCTTTAAAAACAGCTTGTGTATTTCTGCTATAAAATG

>23852_23852_2_DOCK9-STK24_DOCK9_chr13_99607689_ENST00000376460_STK24_chr13_99134575_ENST00000397517_length(amino acids)=448AA_BP=0
LACLCLARPGTRSCSSCRLSDLRFQPRMQADKCRTSSRSVKKELVIESPLQYKDAAQGEVEAESPGPVPAKPKLIEPLDYENVIVQKKTQ
ILNDCLREMLLFPYDDFQDTKLWIIMEYLGGGSALDLLEPGPLDETQIATILREILKGLDYLHSEKKIHRDIKAANVLLSEHGEVKLADF
GVAGQLTDTQIKRNTFVGTPFWMAPEVIKQSAYDSKADIWSLGITAIELARGEPPHSELHPMKVLFLIPKNNPPTLEGNYSKPLKEFVEA
CLNKEPSFRPTAKELLKHKFILRNAKKTSYLTELIDRYKRWKAEQSHDDSSSEDSDAETDGQASGGSDSGDWIFTIREKDPKNLENGALQ

--------------------------------------------------------------
>23852_23852_3_DOCK9-STK24_DOCK9_chr13_99607689_ENST00000442173_STK24_chr13_99134575_ENST00000397517_length(transcript)=4413nt_BP=418nt
GTCATGCCTTCCCACCCCACAGGCTCTGCAGACCCAGCCAGCGGGGCTGACCACTTGTGCCTGGGAAGCCAGTTTCCTTTCCTTCCTTGG
ACCACTGGCATGCCTGTGCCTTGCACGGCCAGGGACTCGCAGCTGTTCCAGTTGCAGACTTTCTGACTTGCGTTTTCAGCCGAGAATGCA
GGCTGATAAATGCAGGACAAGTAGTAGAAGTGTCAAAAAGGAACTGGTGATTGAGTCCCCCCTGCAATACAAGGATGCAGCTCAGGGCGA
AGTGGAAGCAGAGAGCCCGGGCCCTGTGCCGGCAAAGCCAAAGCTAATTGAGCCACTCGACTATGAAAATGTCATCGTCCAGAAGAAGAC
TCAGATCCTGAACGACTGTTTACGGGAGATGCTGCTCTTCCCTTACGATGACTTTCAGGATACAAAATTATGGATAATAATGGAATATCT
TGGTGGAGGCTCCGCACTAGATCTATTAGAACCTGGCCCATTAGATGAAACCCAGATCGCTACTATATTAAGAGAAATACTGAAAGGACT
CGATTATCTCCATTCGGAGAAGAAAATCCACAGAGACATTAAAGCGGCCAACGTCCTGCTGTCTGAGCATGGCGAGGTGAAGCTGGCGGA
CTTTGGCGTGGCTGGCCAGCTGACAGACACCCAGATCAAAAGGAACACCTTCGTGGGCACCCCATTCTGGATGGCACCCGAGGTCATCAA
ACAGTCGGCCTATGACTCGAAGGCAGACATCTGGTCCCTGGGCATAACAGCTATTGAACTTGCAAGAGGGGAACCACCTCATTCCGAGCT
GCACCCCATGAAAGTTTTATTCCTCATTCCAAAGAACAACCCACCGACGTTGGAAGGAAACTACAGTAAACCCCTCAAGGAGTTTGTGGA
GGCCTGTTTGAATAAGGAGCCGAGCTTTAGACCCACTGCTAAGGAGTTATTGAAGCACAAGTTTATACTACGCAATGCAAAGAAAACTTC
CTACTTGACCGAGCTCATCGACAGGTACAAGAGATGGAAGGCCGAGCAGAGCCATGACGACTCGAGCTCCGAGGATTCCGACGCGGAAAC
AGATGGCCAAGCCTCGGGGGGCAGTGATTCTGGGGACTGGATCTTCACAATCCGAGAAAAAGATCCCAAGAATCTCGAGAATGGAGCTCT
TCAGCCATCGGACTTGGACAGAAATAAGATGAAAGACATCCCGAAGAGGCCTTTCTCTCAGTGTTTATCTACAATTATTTCTCCTCTGTT
TGCAGAGTTGAAGGAGAAGAGCCAGGCGTGCGGAGGGAACTTGGGGTCCATTGAAGAGCTGCGAGGGGCCATCTACCTAGCGGAGGAGGC
GTGCCCTGGCATCTCCGACACCATGGTGGCCCAGCTCGTGCAGCGGCTCCAGAGATACTCTCTAAGTGGTGGAGGAACTTCATCCCACTG
AAATTCCTTTGGCATTTGGGGTTTTGTTTTTCCTTTTTTCCTTCTTCATCCTCCTCCTTTTTTAAAAGTCAACGAGAGCCTTCGCTGACT
CCACCGAAGAGGTGCGCCACTGGGAGCCACCCCAGCGCCAGGCGCCCGTCCAGGGACACACACAGTCTTCACTGTGCTGCAGCCAGATGA
AGTCTCTCAGATGGGTGGGGAGGGTCAGCTCCTTCCAGCGATCATTTTATTTTATTTTATTACTTTTGTTTTTAATTTTAACCATAGTGC
ACATATTCCAGGAAAGTGTCTTTAAAAACAAAAACAAACCCTGAAATGTATATTTGGGATTATGATAAGGCAACTAAAGACATGAAACCT
CAGGTATCCTGCTTTAAGTTGATAACTCCCTCTGGGAGCTGGAGAATCGCTCTGGTGGATGGGTGTACAGATTTGTATATAATGTCATTT
TTACGGAAACCCTTTCGGCGTGCATAAGGAATCACTGTGTACAAACTGGCCAAGTGCTTCTGTAGATAACGTCAGTGGAGTAAATATTCG
ACAGGCCATAACTTGAGTCTATTGCCTTGCCTTTATTACATGTACATTTTGAATTCTGTGACCAGTGATTTGGGTTTTATTTTGTATTTG
CAGGGTTTGTCATTAATAATTAATGCCCCTCTCTTACAGAACACTCCTATTTGTACCTCAACAAATGCAAATTTTCCCCGTTTGCCCTAC
GCCCCTTTTGGTACACCTAGAGGTTGATTTCCTTTTTCATCGATGGTACTATTTCTTAGTGTTTTAAATTGGAACATATCTTGCCTCATG
AAGCTTTAAATTATAATTTTCAGTTTCTCCCCATGAAGCGCTCTCGTCTGACATTTGTTTGGAATCGTGCCACTGCTGGTCTGCGCCAGA
TGTACCGTCCTTTCCAATACGATTTTCTGTTGCACCTTGTAGTGGATTCTGCATATCATCTTTCCCACCTAAAAATGTCTGAATGCTTAC
ACAAATAAATTTTATAACACGCTTATTTTGCATACTCCTTGAAATGTGACTCTTCAGAGGACAGGGCACCTGCTGTGTATGTGTGGCCGT
GCGTGTGTACTCGTGGCTGTGTGTGTGTGATGAGACACTTTGGAAGACTCCAGGGAGAAGTCCCCAGGCCTGGAGCTGCCGAGTGCCCAG
GTCAGCGCCCTGGACTGCTTGCGCACTTGCTCACCGAGATGATGCAGTTGGAGGTTGCTGATCTGTGCGATTGCTGTAGCGGTTGCCGGG
GACCTTAAGAGTTATTTTGCTTCTCTGGAAGGGGCCTATGCTTGCTAGGCAGGCAGCCAGTGTGTCTGTTTTTCTTGGTTTGCTGTGGGA
CCTTGCTTGGCGAGGGGGAAAATCTCTGGGTTTCTGGAGTGGGAGGGTTCGTGCAGCAGCTGTTGACTGGTACATGAAGCATTCTTTTAT
GTTTGTTGAAGCTGATGATTGACATCTCCCGTGGGTGTGCCAGTTCTTGTGGAGTTAAGACAGGATTTTTGGAAGCAAGGAAGTTAGTGG
GTGAGCTTGGGGATGTAGCTCAGCTATCTGCTGGTCTAGTGGCCTCTAAGCTATAGGGAGGGGACAGAGCCCTGAGCTACAGATGCTTGA
GTGGGTTATTGTGTCGGTTTGCTAGTGCAGTCTGGTTTTTAAGCTCTAAAATTGAGGTATTTTATTAGAAGTGGATTTGGGTTGAACTCT
TAATTTGTATAAGGGATATATTTTGGTTGGGGAAATAGAACTGAGTTGCTAATTCTTATTGTACTCATTACTCCATACAAGAATGTTATG
TTGAATAATAAAATTGGAGAAGATTTCATTTTGTGTTTCCAGGGAGTATTCTGTGTGGGGAACTGTTTCCTTACGTGAGGCCGGCGGCAT
AAGTCAAAGATGAGTTTTGTCCTTGCGAATCACACAGATTGAGTCTGTGTTCCCCAGGGTGTGCCGTTACCTGATTTTTAAGTGAGCCAG
GGCGGACAGCAGCTTTTCTGATTTACAGAGTTCTTCAGATTTACAAATGGACAATGACATCACAGTTTTTAGCACTGAAGCCAGTCTCAT
GCTAGTAACAGTGGGTGAGCCGCTCGAGGGACTGGGTTCTAATGAATACTGGTATGAACGGGGAGTCTCTGCAGTCGCCAGACAAATCAT
ACTCAGCCCCTTCCCCCGTAGAGCAACAAGTGGTTCTTTTAGAGTTGACTGGCAGCATTTCCTGTCGGGGGAGGTGGGGTTTGATGGAGT
TAGAAAGCTCGCCTCTGTGTACATTCTCTCCTGGGCTGTTACTTTCTGTAGACGCACAAAATCAGCCCCAATGTTTTTAAGGGCATCTTA
GCCAAGGAAGCTGGCTTTTGTGTCGCCACTTCCAGGCCTGCATTAAGAGAGAGCCCAGGCACCAGGGCTACCACTGGAACCTGCCTCAGC
GTCAACTGCTGCTGGTCTGTAGCCAGGCCCAGCCTTTGAGACGGGTTTACTGTCACCAGTAGCCTCTCAGTGCCAGCCCTGAGCTGCTCC
TGGCTCAGCTGCCCAGAGCCTGCAGCCTGGGGAGGTACTCAGCCTCTGGGAGACGAGGGCCGTGGACTGGGTGGCTGGTAGCTCCTGCGT
TTTTGAGCTGTGTCCTGGCTGGCTGCTGCCAATGAGGTGGACACCAGTGTGGTTTGGGGTGCACTGGCCACTTCTTGCTGGGTTCTGATT
TTCTTGGAAGTGCATCTGCCTTCCTTATCCAATAGTTTTATCCCTGCATTGCTCTTGTGAAGTGGCTGGTTTGGTTCTGTATGTAGCATT
TTGTACCTTTCCTCTGGCAAAACACTGTCAGTTTATAAACATTTTTTATATTTCCCTCCTTTAAAAACAGCTTGTGTATTTCTGCTATAA
AATGTGTCAGCAAAGGCAGAGTGACCTAATAGGGCATGTTCTTAAGCACAGGGACTGTATCATGCAGGGGCCAATAAAGCTCAAGAAAAC

>23852_23852_3_DOCK9-STK24_DOCK9_chr13_99607689_ENST00000442173_STK24_chr13_99134575_ENST00000397517_length(amino acids)=471AA_BP=1
MQTQPAGLTTCAWEASFLSFLGPLACLCLARPGTRSCSSCRLSDLRFQPRMQADKCRTSSRSVKKELVIESPLQYKDAAQGEVEAESPGP
VPAKPKLIEPLDYENVIVQKKTQILNDCLREMLLFPYDDFQDTKLWIIMEYLGGGSALDLLEPGPLDETQIATILREILKGLDYLHSEKK
IHRDIKAANVLLSEHGEVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIKQSAYDSKADIWSLGITAIELARGEPPHSELHPMKVLFL
IPKNNPPTLEGNYSKPLKEFVEACLNKEPSFRPTAKELLKHKFILRNAKKTSYLTELIDRYKRWKAEQSHDDSSSEDSDAETDGQASGGS
DSGDWIFTIREKDPKNLENGALQPSDLDRNKMKDIPKRPFSQCLSTIISPLFAELKEKSQACGGNLGSIEELRGAIYLAEEACPGISDTM

--------------------------------------------------------------
>23852_23852_4_DOCK9-STK24_DOCK9_chr13_99607689_ENST00000448493_STK24_chr13_99134575_ENST00000397517_length(transcript)=4385nt_BP=390nt
GACTGCTTGTCACGAAGATGGTACAGTGGGAGCCTGTTTCGGAAGAGCCAAGGAAGAGGATGTGGAAATGGAGTAGAGATTGCTAAAAAA
CTGAACATCCACACCTTGGGGATGGGTTGCACTACTAGTGTGATTCTGTTTAAAGGCATCCGCACCGTTTTTGAAAGAAACTGTGCTTAT
ATGTGCAAACAGCAAGGAGAGAATAATGCCCTTGAATATACAGCATACAATTGGACAAAAGAAGATTCAGAACTATTGATCTCCTCCTGG
CTGGCAAAGCCAAAGCTAATTGAGCCACTCGACTATGAAAATGTCATCGTCCAGAAGAAGACTCAGATCCTGAACGACTGTTTACGGGAG
ATGCTGCTCTTCCCTTACGATGACTTTCAGGATACAAAATTATGGATAATAATGGAATATCTTGGTGGAGGCTCCGCACTAGATCTATTA
GAACCTGGCCCATTAGATGAAACCCAGATCGCTACTATATTAAGAGAAATACTGAAAGGACTCGATTATCTCCATTCGGAGAAGAAAATC
CACAGAGACATTAAAGCGGCCAACGTCCTGCTGTCTGAGCATGGCGAGGTGAAGCTGGCGGACTTTGGCGTGGCTGGCCAGCTGACAGAC
ACCCAGATCAAAAGGAACACCTTCGTGGGCACCCCATTCTGGATGGCACCCGAGGTCATCAAACAGTCGGCCTATGACTCGAAGGCAGAC
ATCTGGTCCCTGGGCATAACAGCTATTGAACTTGCAAGAGGGGAACCACCTCATTCCGAGCTGCACCCCATGAAAGTTTTATTCCTCATT
CCAAAGAACAACCCACCGACGTTGGAAGGAAACTACAGTAAACCCCTCAAGGAGTTTGTGGAGGCCTGTTTGAATAAGGAGCCGAGCTTT
AGACCCACTGCTAAGGAGTTATTGAAGCACAAGTTTATACTACGCAATGCAAAGAAAACTTCCTACTTGACCGAGCTCATCGACAGGTAC
AAGAGATGGAAGGCCGAGCAGAGCCATGACGACTCGAGCTCCGAGGATTCCGACGCGGAAACAGATGGCCAAGCCTCGGGGGGCAGTGAT
TCTGGGGACTGGATCTTCACAATCCGAGAAAAAGATCCCAAGAATCTCGAGAATGGAGCTCTTCAGCCATCGGACTTGGACAGAAATAAG
ATGAAAGACATCCCGAAGAGGCCTTTCTCTCAGTGTTTATCTACAATTATTTCTCCTCTGTTTGCAGAGTTGAAGGAGAAGAGCCAGGCG
TGCGGAGGGAACTTGGGGTCCATTGAAGAGCTGCGAGGGGCCATCTACCTAGCGGAGGAGGCGTGCCCTGGCATCTCCGACACCATGGTG
GCCCAGCTCGTGCAGCGGCTCCAGAGATACTCTCTAAGTGGTGGAGGAACTTCATCCCACTGAAATTCCTTTGGCATTTGGGGTTTTGTT
TTTCCTTTTTTCCTTCTTCATCCTCCTCCTTTTTTAAAAGTCAACGAGAGCCTTCGCTGACTCCACCGAAGAGGTGCGCCACTGGGAGCC
ACCCCAGCGCCAGGCGCCCGTCCAGGGACACACACAGTCTTCACTGTGCTGCAGCCAGATGAAGTCTCTCAGATGGGTGGGGAGGGTCAG
CTCCTTCCAGCGATCATTTTATTTTATTTTATTACTTTTGTTTTTAATTTTAACCATAGTGCACATATTCCAGGAAAGTGTCTTTAAAAA
CAAAAACAAACCCTGAAATGTATATTTGGGATTATGATAAGGCAACTAAAGACATGAAACCTCAGGTATCCTGCTTTAAGTTGATAACTC
CCTCTGGGAGCTGGAGAATCGCTCTGGTGGATGGGTGTACAGATTTGTATATAATGTCATTTTTACGGAAACCCTTTCGGCGTGCATAAG
GAATCACTGTGTACAAACTGGCCAAGTGCTTCTGTAGATAACGTCAGTGGAGTAAATATTCGACAGGCCATAACTTGAGTCTATTGCCTT
GCCTTTATTACATGTACATTTTGAATTCTGTGACCAGTGATTTGGGTTTTATTTTGTATTTGCAGGGTTTGTCATTAATAATTAATGCCC
CTCTCTTACAGAACACTCCTATTTGTACCTCAACAAATGCAAATTTTCCCCGTTTGCCCTACGCCCCTTTTGGTACACCTAGAGGTTGAT
TTCCTTTTTCATCGATGGTACTATTTCTTAGTGTTTTAAATTGGAACATATCTTGCCTCATGAAGCTTTAAATTATAATTTTCAGTTTCT
CCCCATGAAGCGCTCTCGTCTGACATTTGTTTGGAATCGTGCCACTGCTGGTCTGCGCCAGATGTACCGTCCTTTCCAATACGATTTTCT
GTTGCACCTTGTAGTGGATTCTGCATATCATCTTTCCCACCTAAAAATGTCTGAATGCTTACACAAATAAATTTTATAACACGCTTATTT
TGCATACTCCTTGAAATGTGACTCTTCAGAGGACAGGGCACCTGCTGTGTATGTGTGGCCGTGCGTGTGTACTCGTGGCTGTGTGTGTGT
GATGAGACACTTTGGAAGACTCCAGGGAGAAGTCCCCAGGCCTGGAGCTGCCGAGTGCCCAGGTCAGCGCCCTGGACTGCTTGCGCACTT
GCTCACCGAGATGATGCAGTTGGAGGTTGCTGATCTGTGCGATTGCTGTAGCGGTTGCCGGGGACCTTAAGAGTTATTTTGCTTCTCTGG
AAGGGGCCTATGCTTGCTAGGCAGGCAGCCAGTGTGTCTGTTTTTCTTGGTTTGCTGTGGGACCTTGCTTGGCGAGGGGGAAAATCTCTG
GGTTTCTGGAGTGGGAGGGTTCGTGCAGCAGCTGTTGACTGGTACATGAAGCATTCTTTTATGTTTGTTGAAGCTGATGATTGACATCTC
CCGTGGGTGTGCCAGTTCTTGTGGAGTTAAGACAGGATTTTTGGAAGCAAGGAAGTTAGTGGGTGAGCTTGGGGATGTAGCTCAGCTATC
TGCTGGTCTAGTGGCCTCTAAGCTATAGGGAGGGGACAGAGCCCTGAGCTACAGATGCTTGAGTGGGTTATTGTGTCGGTTTGCTAGTGC
AGTCTGGTTTTTAAGCTCTAAAATTGAGGTATTTTATTAGAAGTGGATTTGGGTTGAACTCTTAATTTGTATAAGGGATATATTTTGGTT
GGGGAAATAGAACTGAGTTGCTAATTCTTATTGTACTCATTACTCCATACAAGAATGTTATGTTGAATAATAAAATTGGAGAAGATTTCA
TTTTGTGTTTCCAGGGAGTATTCTGTGTGGGGAACTGTTTCCTTACGTGAGGCCGGCGGCATAAGTCAAAGATGAGTTTTGTCCTTGCGA
ATCACACAGATTGAGTCTGTGTTCCCCAGGGTGTGCCGTTACCTGATTTTTAAGTGAGCCAGGGCGGACAGCAGCTTTTCTGATTTACAG
AGTTCTTCAGATTTACAAATGGACAATGACATCACAGTTTTTAGCACTGAAGCCAGTCTCATGCTAGTAACAGTGGGTGAGCCGCTCGAG
GGACTGGGTTCTAATGAATACTGGTATGAACGGGGAGTCTCTGCAGTCGCCAGACAAATCATACTCAGCCCCTTCCCCCGTAGAGCAACA
AGTGGTTCTTTTAGAGTTGACTGGCAGCATTTCCTGTCGGGGGAGGTGGGGTTTGATGGAGTTAGAAAGCTCGCCTCTGTGTACATTCTC
TCCTGGGCTGTTACTTTCTGTAGACGCACAAAATCAGCCCCAATGTTTTTAAGGGCATCTTAGCCAAGGAAGCTGGCTTTTGTGTCGCCA
CTTCCAGGCCTGCATTAAGAGAGAGCCCAGGCACCAGGGCTACCACTGGAACCTGCCTCAGCGTCAACTGCTGCTGGTCTGTAGCCAGGC
CCAGCCTTTGAGACGGGTTTACTGTCACCAGTAGCCTCTCAGTGCCAGCCCTGAGCTGCTCCTGGCTCAGCTGCCCAGAGCCTGCAGCCT
GGGGAGGTACTCAGCCTCTGGGAGACGAGGGCCGTGGACTGGGTGGCTGGTAGCTCCTGCGTTTTTGAGCTGTGTCCTGGCTGGCTGCTG
CCAATGAGGTGGACACCAGTGTGGTTTGGGGTGCACTGGCCACTTCTTGCTGGGTTCTGATTTTCTTGGAAGTGCATCTGCCTTCCTTAT
CCAATAGTTTTATCCCTGCATTGCTCTTGTGAAGTGGCTGGTTTGGTTCTGTATGTAGCATTTTGTACCTTTCCTCTGGCAAAACACTGT
CAGTTTATAAACATTTTTTATATTTCCCTCCTTTAAAAACAGCTTGTGTATTTCTGCTATAAAATGTGTCAGCAAAGGCAGAGTGACCTA

>23852_23852_4_DOCK9-STK24_DOCK9_chr13_99607689_ENST00000448493_STK24_chr13_99134575_ENST00000397517_length(amino acids)=468AA_BP=1
MSRRWYSGSLFRKSQGRGCGNGVEIAKKLNIHTLGMGCTTSVILFKGIRTVFERNCAYMCKQQGENNALEYTAYNWTKEDSELLISSWLA
KPKLIEPLDYENVIVQKKTQILNDCLREMLLFPYDDFQDTKLWIIMEYLGGGSALDLLEPGPLDETQIATILREILKGLDYLHSEKKIHR
DIKAANVLLSEHGEVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIKQSAYDSKADIWSLGITAIELARGEPPHSELHPMKVLFLIPK
NNPPTLEGNYSKPLKEFVEACLNKEPSFRPTAKELLKHKFILRNAKKTSYLTELIDRYKRWKAEQSHDDSSSEDSDAETDGQASGGSDSG
DWIFTIREKDPKNLENGALQPSDLDRNKMKDIPKRPFSQCLSTIISPLFAELKEKSQACGGNLGSIEELRGAIYLAEEACPGISDTMVAQ

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for DOCK9-STK24


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneDOCK9chr13:99607689chr13:99134575ENST00000339416-2541693_206982.02094.0CDC42
HgeneDOCK9chr13:99607689chr13:99134575ENST00000376460-2571693_206981.02069.0CDC42
HgeneDOCK9chr13:99607689chr13:99134575ENST00000442173-2331693_206981.01254.0CDC42


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for DOCK9-STK24


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for DOCK9-STK24


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneDOCK9C0005586Bipolar Disorder1PSYGENET