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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:FN1-EGF (FusionGDB2 ID:HG2335TG1950)

Fusion Gene Summary for FN1-EGF

Fusion gene summary

Fusion gene information	Fusion gene name: FN1-EGF
	Fusion gene ID: hg2335tg1950
		Hgene	Tgene
	Gene symbol	FN1	EGF
	Gene ID	2335	1950
	Gene name	fibronectin 1	epidermal growth factor
	Synonyms	CIG\|ED-B\|FINC\|FN\|FNZ\|GFND\|GFND2\|LETS\|MSF\|SMDCF	HOMG4\|URG
	Cytomap	('FN1')('EGF') 2q35	4q25
	Type of gene	protein-coding	protein-coding
	Description	fibronectincold-insoluble globulinepididymis secretory sperm binding proteinmigration-stimulating factor	pro-epidermal growth factorbeta-urogastrone
	Modification date	20200329	20200329
	UniProtAcc	P02751	P01133
	Ensembl transtripts involved in fusion gene	ENST00000323926, ENST00000336916, ENST00000345488, ENST00000346544, ENST00000354785, ENST00000356005, ENST00000357009, ENST00000357867, ENST00000359671, ENST00000421182, ENST00000426059, ENST00000432072, ENST00000443816, ENST00000446046, ENST00000490833,
Fusion gene scores	* DoF score	47 X 49 X 13=29939	2 X 4 X 2=16
	# samples	48	2
	** MAII score	log2(48/29939*10)=-5.96284781832542 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(2/16*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0
Context	PubMed: FN1 [Title/Abstract] AND EGF [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	FN1	GO:0001932	regulation of protein phosphorylation	11792823
Hgene	FN1	GO:0008284	positive regulation of cell proliferation	25834989
Hgene	FN1	GO:0010628	positive regulation of gene expression	25834989
Hgene	FN1	GO:0018149	peptide cross-linking	3997886
Hgene	FN1	GO:0034446	substrate adhesion-dependent cell spreading	16236823
Hgene	FN1	GO:0035987	endodermal cell differentiation	23154389
Hgene	FN1	GO:0048146	positive regulation of fibroblast proliferation	25834989
Hgene	FN1	GO:0051702	interaction with symbiont	12167537\|12421310\|19429745
Hgene	FN1	GO:0070372	regulation of ERK1 and ERK2 cascade	11792823
Hgene	FN1	GO:1901166	neural crest cell migration involved in autonomic nervous system development	26571399
Hgene	FN1	GO:1904237	positive regulation of substrate-dependent cell migration, cell attachment to substrate	25834989
Hgene	FN1	GO:2001202	negative regulation of transforming growth factor-beta secretion	25834989
Tgene	EGF	GO:0001525	angiogenesis	15611079
Tgene	EGF	GO:0002092	positive regulation of receptor internalization	22732145
Tgene	EGF	GO:0008284	positive regulation of cell proliferation	7736574\|15611079\|20388803
Tgene	EGF	GO:0010628	positive regulation of gene expression	25678558
Tgene	EGF	GO:0010800	positive regulation of peptidyl-threonine phosphorylation	16314496
Tgene	EGF	GO:0030335	positive regulation of cell migration	25678558
Tgene	EGF	GO:0042327	positive regulation of phosphorylation	15611079
Tgene	EGF	GO:0043406	positive regulation of MAP kinase activity	15611079
Tgene	EGF	GO:0045741	positive regulation of epidermal growth factor-activated receptor activity	15611079\|20353436
Tgene	EGF	GO:0045840	positive regulation of mitotic nuclear division	15611079
Tgene	EGF	GO:0045893	positive regulation of transcription, DNA-templated	16314496
Tgene	EGF	GO:0051048	negative regulation of secretion	10559227
Tgene	EGF	GO:0070371	ERK1 and ERK2 cascade	16314496
Tgene	EGF	GO:0090263	positive regulation of canonical Wnt signaling pathway	20302655
Tgene	EGF	GO:0090279	regulation of calcium ion import	19996314
Tgene	EGF	GO:1900127	positive regulation of hyaluronan biosynthetic process	17324121
Tgene	EGF	GO:1902966	positive regulation of protein localization to early endosome	22298428
Tgene	EGF	GO:2000008	regulation of protein localization to cell surface	19996314

Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerKB4	.	.	FN1	chr2	216232750	-	EGF	chr4	216232750	+
ChimerKB4	.	.	FN1	chr2	216253024	-	EGF	chr4	216253024	+
ChimerKB4	.	.	FN1	chr2	216261946	-	EGF	chr4	216261946	+

Top

Fusion Gene ORF analysis for FN1-EGF

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
intron-intron	ENST00000323926	ENST00000265171	FN1	chr2	216232750	-	EGF	chr4	216232750	+
intron-intron	ENST00000323926	ENST00000265171	FN1	chr2	216253024	-	EGF	chr4	216253024	+
intron-intron	ENST00000323926	ENST00000265171	FN1	chr2	216261946	-	EGF	chr4	216261946	+
intron-intron	ENST00000323926	ENST00000502723	FN1	chr2	216232750	-	EGF	chr4	216232750	+
intron-intron	ENST00000323926	ENST00000502723	FN1	chr2	216253024	-	EGF	chr4	216253024	+
intron-intron	ENST00000323926	ENST00000502723	FN1	chr2	216261946	-	EGF	chr4	216261946	+
intron-intron	ENST00000323926	ENST00000503392	FN1	chr2	216232750	-	EGF	chr4	216232750	+
intron-intron	ENST00000323926	ENST00000503392	FN1	chr2	216253024	-	EGF	chr4	216253024	+
intron-intron	ENST00000323926	ENST00000503392	FN1	chr2	216261946	-	EGF	chr4	216261946	+
intron-intron	ENST00000323926	ENST00000509793	FN1	chr2	216232750	-	EGF	chr4	216232750	+
intron-intron	ENST00000323926	ENST00000509793	FN1	chr2	216253024	-	EGF	chr4	216253024	+
intron-intron	ENST00000323926	ENST00000509793	FN1	chr2	216261946	-	EGF	chr4	216261946	+
intron-intron	ENST00000336916	ENST00000265171	FN1	chr2	216232750	-	EGF	chr4	216232750	+
intron-intron	ENST00000336916	ENST00000265171	FN1	chr2	216253024	-	EGF	chr4	216253024	+
intron-intron	ENST00000336916	ENST00000265171	FN1	chr2	216261946	-	EGF	chr4	216261946	+
intron-intron	ENST00000336916	ENST00000502723	FN1	chr2	216232750	-	EGF	chr4	216232750	+
intron-intron	ENST00000336916	ENST00000502723	FN1	chr2	216253024	-	EGF	chr4	216253024	+
intron-intron	ENST00000336916	ENST00000502723	FN1	chr2	216261946	-	EGF	chr4	216261946	+
intron-intron	ENST00000336916	ENST00000503392	FN1	chr2	216232750	-	EGF	chr4	216232750	+
intron-intron	ENST00000336916	ENST00000503392	FN1	chr2	216253024	-	EGF	chr4	216253024	+
intron-intron	ENST00000336916	ENST00000503392	FN1	chr2	216261946	-	EGF	chr4	216261946	+
intron-intron	ENST00000336916	ENST00000509793	FN1	chr2	216232750	-	EGF	chr4	216232750	+
intron-intron	ENST00000336916	ENST00000509793	FN1	chr2	216253024	-	EGF	chr4	216253024	+
intron-intron	ENST00000336916	ENST00000509793	FN1	chr2	216261946	-	EGF	chr4	216261946	+
intron-intron	ENST00000345488	ENST00000265171	FN1	chr2	216232750	-	EGF	chr4	216232750	+
intron-intron	ENST00000345488	ENST00000265171	FN1	chr2	216253024	-	EGF	chr4	216253024	+
intron-intron	ENST00000345488	ENST00000265171	FN1	chr2	216261946	-	EGF	chr4	216261946	+
intron-intron	ENST00000345488	ENST00000502723	FN1	chr2	216232750	-	EGF	chr4	216232750	+
intron-intron	ENST00000345488	ENST00000502723	FN1	chr2	216253024	-	EGF	chr4	216253024	+
intron-intron	ENST00000345488	ENST00000502723	FN1	chr2	216261946	-	EGF	chr4	216261946	+
intron-intron	ENST00000345488	ENST00000503392	FN1	chr2	216232750	-	EGF	chr4	216232750	+
intron-intron	ENST00000345488	ENST00000503392	FN1	chr2	216253024	-	EGF	chr4	216253024	+
intron-intron	ENST00000345488	ENST00000503392	FN1	chr2	216261946	-	EGF	chr4	216261946	+
intron-intron	ENST00000345488	ENST00000509793	FN1	chr2	216232750	-	EGF	chr4	216232750	+
intron-intron	ENST00000345488	ENST00000509793	FN1	chr2	216253024	-	EGF	chr4	216253024	+
intron-intron	ENST00000345488	ENST00000509793	FN1	chr2	216261946	-	EGF	chr4	216261946	+
intron-intron	ENST00000346544	ENST00000265171	FN1	chr2	216232750	-	EGF	chr4	216232750	+
intron-intron	ENST00000346544	ENST00000265171	FN1	chr2	216253024	-	EGF	chr4	216253024	+
intron-intron	ENST00000346544	ENST00000265171	FN1	chr2	216261946	-	EGF	chr4	216261946	+
intron-intron	ENST00000346544	ENST00000502723	FN1	chr2	216232750	-	EGF	chr4	216232750	+
intron-intron	ENST00000346544	ENST00000502723	FN1	chr2	216253024	-	EGF	chr4	216253024	+
intron-intron	ENST00000346544	ENST00000502723	FN1	chr2	216261946	-	EGF	chr4	216261946	+
intron-intron	ENST00000346544	ENST00000503392	FN1	chr2	216232750	-	EGF	chr4	216232750	+
intron-intron	ENST00000346544	ENST00000503392	FN1	chr2	216253024	-	EGF	chr4	216253024	+
intron-intron	ENST00000346544	ENST00000503392	FN1	chr2	216261946	-	EGF	chr4	216261946	+
intron-intron	ENST00000346544	ENST00000509793	FN1	chr2	216232750	-	EGF	chr4	216232750	+
intron-intron	ENST00000346544	ENST00000509793	FN1	chr2	216253024	-	EGF	chr4	216253024	+
intron-intron	ENST00000346544	ENST00000509793	FN1	chr2	216261946	-	EGF	chr4	216261946	+
intron-intron	ENST00000354785	ENST00000265171	FN1	chr2	216232750	-	EGF	chr4	216232750	+
intron-intron	ENST00000354785	ENST00000265171	FN1	chr2	216253024	-	EGF	chr4	216253024	+
intron-intron	ENST00000354785	ENST00000265171	FN1	chr2	216261946	-	EGF	chr4	216261946	+
intron-intron	ENST00000354785	ENST00000502723	FN1	chr2	216232750	-	EGF	chr4	216232750	+
intron-intron	ENST00000354785	ENST00000502723	FN1	chr2	216253024	-	EGF	chr4	216253024	+
intron-intron	ENST00000354785	ENST00000502723	FN1	chr2	216261946	-	EGF	chr4	216261946	+
intron-intron	ENST00000354785	ENST00000503392	FN1	chr2	216232750	-	EGF	chr4	216232750	+
intron-intron	ENST00000354785	ENST00000503392	FN1	chr2	216253024	-	EGF	chr4	216253024	+
intron-intron	ENST00000354785	ENST00000503392	FN1	chr2	216261946	-	EGF	chr4	216261946	+
intron-intron	ENST00000354785	ENST00000509793	FN1	chr2	216232750	-	EGF	chr4	216232750	+
intron-intron	ENST00000354785	ENST00000509793	FN1	chr2	216253024	-	EGF	chr4	216253024	+
intron-intron	ENST00000354785	ENST00000509793	FN1	chr2	216261946	-	EGF	chr4	216261946	+
intron-intron	ENST00000356005	ENST00000265171	FN1	chr2	216232750	-	EGF	chr4	216232750	+
intron-intron	ENST00000356005	ENST00000265171	FN1	chr2	216253024	-	EGF	chr4	216253024	+
intron-intron	ENST00000356005	ENST00000265171	FN1	chr2	216261946	-	EGF	chr4	216261946	+
intron-intron	ENST00000356005	ENST00000502723	FN1	chr2	216232750	-	EGF	chr4	216232750	+
intron-intron	ENST00000356005	ENST00000502723	FN1	chr2	216253024	-	EGF	chr4	216253024	+
intron-intron	ENST00000356005	ENST00000502723	FN1	chr2	216261946	-	EGF	chr4	216261946	+
intron-intron	ENST00000356005	ENST00000503392	FN1	chr2	216232750	-	EGF	chr4	216232750	+
intron-intron	ENST00000356005	ENST00000503392	FN1	chr2	216253024	-	EGF	chr4	216253024	+
intron-intron	ENST00000356005	ENST00000503392	FN1	chr2	216261946	-	EGF	chr4	216261946	+
intron-intron	ENST00000356005	ENST00000509793	FN1	chr2	216232750	-	EGF	chr4	216232750	+
intron-intron	ENST00000356005	ENST00000509793	FN1	chr2	216253024	-	EGF	chr4	216253024	+
intron-intron	ENST00000356005	ENST00000509793	FN1	chr2	216261946	-	EGF	chr4	216261946	+
intron-intron	ENST00000357009	ENST00000265171	FN1	chr2	216232750	-	EGF	chr4	216232750	+
intron-intron	ENST00000357009	ENST00000265171	FN1	chr2	216253024	-	EGF	chr4	216253024	+
intron-intron	ENST00000357009	ENST00000265171	FN1	chr2	216261946	-	EGF	chr4	216261946	+
intron-intron	ENST00000357009	ENST00000502723	FN1	chr2	216232750	-	EGF	chr4	216232750	+
intron-intron	ENST00000357009	ENST00000502723	FN1	chr2	216253024	-	EGF	chr4	216253024	+
intron-intron	ENST00000357009	ENST00000502723	FN1	chr2	216261946	-	EGF	chr4	216261946	+
intron-intron	ENST00000357009	ENST00000503392	FN1	chr2	216232750	-	EGF	chr4	216232750	+
intron-intron	ENST00000357009	ENST00000503392	FN1	chr2	216253024	-	EGF	chr4	216253024	+
intron-intron	ENST00000357009	ENST00000503392	FN1	chr2	216261946	-	EGF	chr4	216261946	+
intron-intron	ENST00000357009	ENST00000509793	FN1	chr2	216232750	-	EGF	chr4	216232750	+
intron-intron	ENST00000357009	ENST00000509793	FN1	chr2	216253024	-	EGF	chr4	216253024	+
intron-intron	ENST00000357009	ENST00000509793	FN1	chr2	216261946	-	EGF	chr4	216261946	+
intron-intron	ENST00000357867	ENST00000265171	FN1	chr2	216232750	-	EGF	chr4	216232750	+
intron-intron	ENST00000357867	ENST00000265171	FN1	chr2	216253024	-	EGF	chr4	216253024	+
intron-intron	ENST00000357867	ENST00000265171	FN1	chr2	216261946	-	EGF	chr4	216261946	+
intron-intron	ENST00000357867	ENST00000502723	FN1	chr2	216232750	-	EGF	chr4	216232750	+
intron-intron	ENST00000357867	ENST00000502723	FN1	chr2	216253024	-	EGF	chr4	216253024	+
intron-intron	ENST00000357867	ENST00000502723	FN1	chr2	216261946	-	EGF	chr4	216261946	+
intron-intron	ENST00000357867	ENST00000503392	FN1	chr2	216232750	-	EGF	chr4	216232750	+
intron-intron	ENST00000357867	ENST00000503392	FN1	chr2	216253024	-	EGF	chr4	216253024	+
intron-intron	ENST00000357867	ENST00000503392	FN1	chr2	216261946	-	EGF	chr4	216261946	+
intron-intron	ENST00000357867	ENST00000509793	FN1	chr2	216232750	-	EGF	chr4	216232750	+
intron-intron	ENST00000357867	ENST00000509793	FN1	chr2	216253024	-	EGF	chr4	216253024	+
intron-intron	ENST00000357867	ENST00000509793	FN1	chr2	216261946	-	EGF	chr4	216261946	+
intron-intron	ENST00000359671	ENST00000265171	FN1	chr2	216232750	-	EGF	chr4	216232750	+
intron-intron	ENST00000359671	ENST00000265171	FN1	chr2	216253024	-	EGF	chr4	216253024	+
intron-intron	ENST00000359671	ENST00000265171	FN1	chr2	216261946	-	EGF	chr4	216261946	+
intron-intron	ENST00000359671	ENST00000502723	FN1	chr2	216232750	-	EGF	chr4	216232750	+
intron-intron	ENST00000359671	ENST00000502723	FN1	chr2	216253024	-	EGF	chr4	216253024	+
intron-intron	ENST00000359671	ENST00000502723	FN1	chr2	216261946	-	EGF	chr4	216261946	+
intron-intron	ENST00000359671	ENST00000503392	FN1	chr2	216232750	-	EGF	chr4	216232750	+
intron-intron	ENST00000359671	ENST00000503392	FN1	chr2	216253024	-	EGF	chr4	216253024	+
intron-intron	ENST00000359671	ENST00000503392	FN1	chr2	216261946	-	EGF	chr4	216261946	+
intron-intron	ENST00000359671	ENST00000509793	FN1	chr2	216232750	-	EGF	chr4	216232750	+
intron-intron	ENST00000359671	ENST00000509793	FN1	chr2	216253024	-	EGF	chr4	216253024	+
intron-intron	ENST00000359671	ENST00000509793	FN1	chr2	216261946	-	EGF	chr4	216261946	+
intron-intron	ENST00000421182	ENST00000265171	FN1	chr2	216232750	-	EGF	chr4	216232750	+
intron-intron	ENST00000421182	ENST00000265171	FN1	chr2	216253024	-	EGF	chr4	216253024	+
intron-intron	ENST00000421182	ENST00000265171	FN1	chr2	216261946	-	EGF	chr4	216261946	+
intron-intron	ENST00000421182	ENST00000502723	FN1	chr2	216232750	-	EGF	chr4	216232750	+
intron-intron	ENST00000421182	ENST00000502723	FN1	chr2	216253024	-	EGF	chr4	216253024	+
intron-intron	ENST00000421182	ENST00000502723	FN1	chr2	216261946	-	EGF	chr4	216261946	+
intron-intron	ENST00000421182	ENST00000503392	FN1	chr2	216232750	-	EGF	chr4	216232750	+
intron-intron	ENST00000421182	ENST00000503392	FN1	chr2	216253024	-	EGF	chr4	216253024	+
intron-intron	ENST00000421182	ENST00000503392	FN1	chr2	216261946	-	EGF	chr4	216261946	+
intron-intron	ENST00000421182	ENST00000509793	FN1	chr2	216232750	-	EGF	chr4	216232750	+
intron-intron	ENST00000421182	ENST00000509793	FN1	chr2	216253024	-	EGF	chr4	216253024	+
intron-intron	ENST00000421182	ENST00000509793	FN1	chr2	216261946	-	EGF	chr4	216261946	+
intron-intron	ENST00000426059	ENST00000265171	FN1	chr2	216232750	-	EGF	chr4	216232750	+
intron-intron	ENST00000426059	ENST00000265171	FN1	chr2	216253024	-	EGF	chr4	216253024	+
intron-intron	ENST00000426059	ENST00000265171	FN1	chr2	216261946	-	EGF	chr4	216261946	+
intron-intron	ENST00000426059	ENST00000502723	FN1	chr2	216232750	-	EGF	chr4	216232750	+
intron-intron	ENST00000426059	ENST00000502723	FN1	chr2	216253024	-	EGF	chr4	216253024	+
intron-intron	ENST00000426059	ENST00000502723	FN1	chr2	216261946	-	EGF	chr4	216261946	+
intron-intron	ENST00000426059	ENST00000503392	FN1	chr2	216232750	-	EGF	chr4	216232750	+
intron-intron	ENST00000426059	ENST00000503392	FN1	chr2	216253024	-	EGF	chr4	216253024	+
intron-intron	ENST00000426059	ENST00000503392	FN1	chr2	216261946	-	EGF	chr4	216261946	+
intron-intron	ENST00000426059	ENST00000509793	FN1	chr2	216232750	-	EGF	chr4	216232750	+
intron-intron	ENST00000426059	ENST00000509793	FN1	chr2	216253024	-	EGF	chr4	216253024	+
intron-intron	ENST00000426059	ENST00000509793	FN1	chr2	216261946	-	EGF	chr4	216261946	+
intron-intron	ENST00000432072	ENST00000265171	FN1	chr2	216232750	-	EGF	chr4	216232750	+
intron-intron	ENST00000432072	ENST00000265171	FN1	chr2	216253024	-	EGF	chr4	216253024	+
intron-intron	ENST00000432072	ENST00000265171	FN1	chr2	216261946	-	EGF	chr4	216261946	+
intron-intron	ENST00000432072	ENST00000502723	FN1	chr2	216232750	-	EGF	chr4	216232750	+
intron-intron	ENST00000432072	ENST00000502723	FN1	chr2	216253024	-	EGF	chr4	216253024	+
intron-intron	ENST00000432072	ENST00000502723	FN1	chr2	216261946	-	EGF	chr4	216261946	+
intron-intron	ENST00000432072	ENST00000503392	FN1	chr2	216232750	-	EGF	chr4	216232750	+
intron-intron	ENST00000432072	ENST00000503392	FN1	chr2	216253024	-	EGF	chr4	216253024	+
intron-intron	ENST00000432072	ENST00000503392	FN1	chr2	216261946	-	EGF	chr4	216261946	+
intron-intron	ENST00000432072	ENST00000509793	FN1	chr2	216232750	-	EGF	chr4	216232750	+
intron-intron	ENST00000432072	ENST00000509793	FN1	chr2	216253024	-	EGF	chr4	216253024	+
intron-intron	ENST00000432072	ENST00000509793	FN1	chr2	216261946	-	EGF	chr4	216261946	+
intron-intron	ENST00000443816	ENST00000265171	FN1	chr2	216232750	-	EGF	chr4	216232750	+
intron-intron	ENST00000443816	ENST00000265171	FN1	chr2	216253024	-	EGF	chr4	216253024	+
intron-intron	ENST00000443816	ENST00000265171	FN1	chr2	216261946	-	EGF	chr4	216261946	+
intron-intron	ENST00000443816	ENST00000502723	FN1	chr2	216232750	-	EGF	chr4	216232750	+
intron-intron	ENST00000443816	ENST00000502723	FN1	chr2	216253024	-	EGF	chr4	216253024	+
intron-intron	ENST00000443816	ENST00000502723	FN1	chr2	216261946	-	EGF	chr4	216261946	+
intron-intron	ENST00000443816	ENST00000503392	FN1	chr2	216232750	-	EGF	chr4	216232750	+
intron-intron	ENST00000443816	ENST00000503392	FN1	chr2	216253024	-	EGF	chr4	216253024	+
intron-intron	ENST00000443816	ENST00000503392	FN1	chr2	216261946	-	EGF	chr4	216261946	+
intron-intron	ENST00000443816	ENST00000509793	FN1	chr2	216232750	-	EGF	chr4	216232750	+
intron-intron	ENST00000443816	ENST00000509793	FN1	chr2	216253024	-	EGF	chr4	216253024	+
intron-intron	ENST00000443816	ENST00000509793	FN1	chr2	216261946	-	EGF	chr4	216261946	+
intron-intron	ENST00000446046	ENST00000265171	FN1	chr2	216232750	-	EGF	chr4	216232750	+
intron-intron	ENST00000446046	ENST00000265171	FN1	chr2	216253024	-	EGF	chr4	216253024	+
intron-intron	ENST00000446046	ENST00000265171	FN1	chr2	216261946	-	EGF	chr4	216261946	+
intron-intron	ENST00000446046	ENST00000502723	FN1	chr2	216232750	-	EGF	chr4	216232750	+
intron-intron	ENST00000446046	ENST00000502723	FN1	chr2	216253024	-	EGF	chr4	216253024	+
intron-intron	ENST00000446046	ENST00000502723	FN1	chr2	216261946	-	EGF	chr4	216261946	+
intron-intron	ENST00000446046	ENST00000503392	FN1	chr2	216232750	-	EGF	chr4	216232750	+
intron-intron	ENST00000446046	ENST00000503392	FN1	chr2	216253024	-	EGF	chr4	216253024	+
intron-intron	ENST00000446046	ENST00000503392	FN1	chr2	216261946	-	EGF	chr4	216261946	+
intron-intron	ENST00000446046	ENST00000509793	FN1	chr2	216232750	-	EGF	chr4	216232750	+
intron-intron	ENST00000446046	ENST00000509793	FN1	chr2	216253024	-	EGF	chr4	216253024	+
intron-intron	ENST00000446046	ENST00000509793	FN1	chr2	216261946	-	EGF	chr4	216261946	+
intron-intron	ENST00000490833	ENST00000265171	FN1	chr2	216232750	-	EGF	chr4	216232750	+
intron-intron	ENST00000490833	ENST00000265171	FN1	chr2	216253024	-	EGF	chr4	216253024	+
intron-intron	ENST00000490833	ENST00000265171	FN1	chr2	216261946	-	EGF	chr4	216261946	+
intron-intron	ENST00000490833	ENST00000502723	FN1	chr2	216232750	-	EGF	chr4	216232750	+
intron-intron	ENST00000490833	ENST00000502723	FN1	chr2	216253024	-	EGF	chr4	216253024	+
intron-intron	ENST00000490833	ENST00000502723	FN1	chr2	216261946	-	EGF	chr4	216261946	+
intron-intron	ENST00000490833	ENST00000503392	FN1	chr2	216232750	-	EGF	chr4	216232750	+
intron-intron	ENST00000490833	ENST00000503392	FN1	chr2	216253024	-	EGF	chr4	216253024	+
intron-intron	ENST00000490833	ENST00000503392	FN1	chr2	216261946	-	EGF	chr4	216261946	+
intron-intron	ENST00000490833	ENST00000509793	FN1	chr2	216232750	-	EGF	chr4	216232750	+
intron-intron	ENST00000490833	ENST00000509793	FN1	chr2	216253024	-	EGF	chr4	216253024	+
intron-intron	ENST00000490833	ENST00000509793	FN1	chr2	216261946	-	EGF	chr4	216261946	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

No-coding score

Coding score

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Fusion Genomic Features for FN1-EGF

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

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Fusion Protein Features for FN1-EGF

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:/:)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
FN1 P02751	EGF P01133
FUNCTION: Fibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin (PubMed:3024962, PubMed:3900070, PubMed:3593230, PubMed:7989369). Fibronectins are involved in cell adhesion, cell motility, opsonization, wound healing, and maintenance of cell shape (PubMed:3024962, PubMed:3900070, PubMed:3593230, PubMed:7989369). Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process, essential for osteoblast mineralization (By similarity). Participates in the regulation of type I collagen deposition by osteoblasts (By similarity). Acts as a ligand for the LILRB4 receptor, inhibiting FCGR1A/CD64-mediated monocyte activation (PubMed:34089617). {ECO:0000250\|UniProtKB:P11276, ECO:0000269\|PubMed:3024962, ECO:0000269\|PubMed:34089617, ECO:0000269\|PubMed:3593230, ECO:0000269\|PubMed:3900070, ECO:0000269\|PubMed:7989369}.; FUNCTION: [Anastellin]: Binds fibronectin and induces fibril formation. This fibronectin polymer, named superfibronectin, exhibits enhanced adhesive properties. Both anastellin and superfibronectin inhibit tumor growth, angiogenesis and metastasis. Anastellin activates p38 MAPK and inhibits lysophospholipid signaling. {ECO:0000269\|PubMed:11209058, ECO:0000269\|PubMed:15665290, ECO:0000269\|PubMed:19379667, ECO:0000269\|PubMed:8114919}.	FUNCTION: EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. Can induce neurite outgrowth in motoneurons of the pond snail Lymnaea stagnalis in vitro (PubMed:10964941). {ECO:0000269\|PubMed:10964941, ECO:0000269\|PubMed:17671655}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

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Fusion Gene Sequence for FN1-EGF

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for FN1-EGF

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for FN1-EGF

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner	Gene	UniProtAcc	DrugBank ID	Drug name	Drug activity	Drug type	Drug status
Hgene	FN1	P02751	DB08888	Ocriplasmin	Cleavage	Biotech	Approved
Hgene	FN1	P02751	DB08888	Ocriplasmin	Cleavage	Biotech	Approved
Hgene	FN1	P02751	DB14548	Zinc sulfate, unspecified form	Ligand\|Modulator	Small molecule	Approved\|Experimental
Hgene	FN1	P02751	DB14548	Zinc sulfate, unspecified form	Ligand\|Modulator	Small molecule	Approved\|Experimental
Hgene	FN1	P02751	DB01593	Zinc		Small molecule	Approved\|Investigational
Hgene	FN1	P02751	DB01593	Zinc		Small molecule	Approved\|Investigational
Hgene	FN1	P02751	DB14487	Zinc acetate		Small molecule	Approved\|Investigational
Hgene	FN1	P02751	DB14487	Zinc acetate		Small molecule	Approved\|Investigational
Hgene	FN1	P02751	DB14533	Zinc chloride	Ligand\|Modulator	Small molecule	Approved\|Investigational
Hgene	FN1	P02751	DB14533	Zinc chloride	Ligand\|Modulator	Small molecule	Approved\|Investigational
Tgene	EGF	P01133	DB00364	Sucralfate	Inducer	Small molecule	Approved
Tgene	EGF	P01133	DB08862	Cholecystokinin		Small molecule	Approved\|Investigational

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Related Diseases for FN1-EGF

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Hgene	FN1	C0020538	Hypertensive disease	2	CTD_human
Hgene	FN1	C0432221	Spondylometaphyseal dysplasia, 'corner fracture' type	2	GENOMICS_ENGLAND;ORPHANET;UNIPROT
Hgene	FN1	C0000786	Spontaneous abortion	1	CTD_human
Hgene	FN1	C0000822	Abortion, Tubal	1	CTD_human
Hgene	FN1	C0003504	Aortic Valve Insufficiency	1	CTD_human
Hgene	FN1	C0006142	Malignant neoplasm of breast	1	CTD_human;UNIPROT
Hgene	FN1	C0007097	Carcinoma	1	CTD_human
Hgene	FN1	C0007621	Neoplastic Cell Transformation	1	CTD_human
Hgene	FN1	C0010346	Crohn Disease	1	CTD_human
Hgene	FN1	C0011849	Diabetes Mellitus	1	CTD_human
Hgene	FN1	C0011881	Diabetic Nephropathy	1	CTD_human
Hgene	FN1	C0017636	Glioblastoma	1	CTD_human
Hgene	FN1	C0017667	Nodular glomerulosclerosis	1	CTD_human
Hgene	FN1	C0017668	Focal glomerulosclerosis	1	CTD_human
Hgene	FN1	C0024667	Animal Mammary Neoplasms	1	CTD_human
Hgene	FN1	C0024668	Mammary Neoplasms, Experimental	1	CTD_human
Hgene	FN1	C0027626	Neoplasm Invasiveness	1	CTD_human
Hgene	FN1	C0034069	Pulmonary Fibrosis	1	CTD_human
Hgene	FN1	C0041956	Ureteral obstruction	1	CTD_human
Hgene	FN1	C0085762	Alcohol abuse	1	PSYGENET
Hgene	FN1	C0086432	Hyalinosis, Segmental Glomerular	1	CTD_human
Hgene	FN1	C0149721	Left Ventricular Hypertrophy	1	CTD_human
Hgene	FN1	C0156147	Crohn's disease of large bowel	1	CTD_human
Hgene	FN1	C0205696	Anaplastic carcinoma	1	CTD_human
Hgene	FN1	C0205697	Carcinoma, Spindle-Cell	1	CTD_human
Hgene	FN1	C0205698	Undifferentiated carcinoma	1	CTD_human
Hgene	FN1	C0205699	Carcinomatosis	1	CTD_human
Hgene	FN1	C0267380	Crohn's disease of the ileum	1	CTD_human
Hgene	FN1	C0334588	Giant Cell Glioblastoma	1	CTD_human
Hgene	FN1	C0345967	Malignant mesothelioma	1	CTD_human
Hgene	FN1	C0678202	Regional enteritis	1	CTD_human
Hgene	FN1	C0678222	Breast Carcinoma	1	CTD_human
Hgene	FN1	C0949272	IIeocolitis	1	CTD_human
Hgene	FN1	C1257925	Mammary Carcinoma, Animal	1	CTD_human
Hgene	FN1	C1257931	Mammary Neoplasms, Human	1	CTD_human
Hgene	FN1	C1458155	Mammary Neoplasms	1	CTD_human
Hgene	FN1	C1621958	Glioblastoma Multiforme	1	CTD_human
Hgene	FN1	C1866075	GLOMERULOPATHY WITH FIBRONECTIN DEPOSITS 2 (disorder)	1	CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
Hgene	FN1	C3830362	Early Pregnancy Loss	1	CTD_human
Hgene	FN1	C3888104	Glomerulopathy with fibronectin deposits	1	CTD_human;ORPHANET
Hgene	FN1	C4552766	Miscarriage	1	CTD_human
Hgene	FN1	C4704874	Mammary Carcinoma, Human	1	CTD_human
Hgene	FN1	C4721507	Alveolitis, Fibrosing	1	CTD_human
Tgene		C0027626	Neoplasm Invasiveness	5	CTD_human
Tgene		C0006142	Malignant neoplasm of breast	3	CTD_human
Tgene		C0007621	Neoplastic Cell Transformation	3	CTD_human
Tgene		C0678222	Breast Carcinoma	3	CTD_human
Tgene		C1257931	Mammary Neoplasms, Human	3	CTD_human
Tgene		C1458155	Mammary Neoplasms	3	CTD_human
Tgene		C4704874	Mammary Carcinoma, Human	3	CTD_human
Tgene		C0001973	Alcoholic Intoxication, Chronic	2	PSYGENET
Tgene		C0027627	Neoplasm Metastasis	2	CTD_human
Tgene		C0038358	Gastric ulcer	2	CTD_human
Tgene		C0001418	Adenocarcinoma	1	CTD_human
Tgene		C0004352	Autistic Disorder	1	CTD_human
Tgene		C0008925	Cleft Palate	1	CTD_human
Tgene		C0011603	Dermatitis	1	CTD_human
Tgene		C0017636	Glioblastoma	1	CTD_human
Tgene		C0022658	Kidney Diseases	1	CTD_human
Tgene		C0023893	Liver Cirrhosis, Experimental	1	CTD_human
Tgene		C0025568	Metaplasia	1	CTD_human
Tgene		C0032927	Precancerous Conditions	1	CTD_human
Tgene		C0033578	Prostatic Neoplasms	1	CTD_human
Tgene		C0034069	Pulmonary Fibrosis	1	CTD_human
Tgene		C0035126	Reperfusion Injury	1	CTD_human
Tgene		C0041696	Unipolar Depression	1	PSYGENET
Tgene		C0087031	Juvenile-Onset Still Disease	1	CTD_human
Tgene		C0205641	Adenocarcinoma, Basal Cell	1	CTD_human
Tgene		C0205642	Adenocarcinoma, Oxyphilic	1	CTD_human
Tgene		C0205643	Carcinoma, Cribriform	1	CTD_human
Tgene		C0205644	Carcinoma, Granular Cell	1	CTD_human
Tgene		C0205645	Adenocarcinoma, Tubular	1	CTD_human
Tgene		C0235874	Disease Exacerbation	1	CTD_human
Tgene		C0279607	Adult Hepatocellular Carcinoma	1	ORPHANET
Tgene		C0282313	Condition, Preneoplastic	1	CTD_human
Tgene		C0334588	Giant Cell Glioblastoma	1	CTD_human
Tgene		C0376358	Malignant neoplasm of prostate	1	CTD_human
Tgene		C1269683	Major Depressive Disorder	1	PSYGENET
Tgene		C1621958	Glioblastoma Multiforme	1	CTD_human
Tgene		C1837218	Cleft palate, isolated	1	CTD_human
Tgene		C2239176	Liver carcinoma	1	CTD_human
Tgene		C2673648	Hypomagnesemia 4, Renal	1	CTD_human;GENOMICS_ENGLAND;UNIPROT
Tgene		C3495559	Juvenile arthritis	1	CTD_human
Tgene		C3714758	Juvenile psoriatic arthritis	1	CTD_human
Tgene		C4510731	Familial primary hypomagnesemia with normocalciuria and normocalcemia	1	ORPHANET
Tgene		C4552091	Polyarthritis, Juvenile, Rheumatoid Factor Negative	1	CTD_human
Tgene		C4704862	Polyarthritis, Juvenile, Rheumatoid Factor Positive	1	CTD_human
Tgene		C4721507	Alveolitis, Fibrosing	1	CTD_human

Fusion Gene Studies in Kim Lab

Fusion gene:FN1-EGF (FusionGDB2 ID:HG2335TG1950)

Fusion Gene Summary for FN1-EGF

Fusion Gene ORF analysis for FN1-EGF

Fusion Genomic Features for FN1-EGF

Fusion Protein Features for FN1-EGF

Fusion Gene Sequence for FN1-EGF

Fusion Gene PPI Analysis for FN1-EGF

Related Drugs for FN1-EGF

Related Diseases for FN1-EGF

Fusion Gene Studies
in Kim Lab