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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ADNP-SYCP2 (FusionGDB2 ID:HG23394TG10388)

Fusion Gene Summary for ADNP-SYCP2

check button Fusion gene summary
Fusion gene informationFusion gene name: ADNP-SYCP2
Fusion gene ID: hg23394tg10388
HgeneTgene
Gene symbol

ADNP

SYCP2

Gene ID

23394

10388

Gene nameactivity dependent neuroprotector homeoboxsynaptonemal complex protein 2
SynonymsADNP1|HVDAS|MRD28SCP-2|SCP2|SPGF1
Cytomap('ADNP')('SYCP2')

20q13.13

20q13.33

Type of geneprotein-codingprotein-coding
Descriptionactivity-dependent neuroprotector homeobox proteinADNP homeobox 1activity-dependent neuroprotective proteinactivity-dependent neuroprotectorsynaptonemal complex protein 2synaptonemal complex lateral element protein
Modification date2020032220200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000349014, ENST00000371602, 
ENST00000396029, ENST00000396032, 
Fusion gene scores* DoF score17 X 7 X 11=13093 X 3 X 2=18
# samples 223
** MAII scorelog2(22/1309*10)=-2.57288966842058
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: ADNP [Title/Abstract] AND SYCP2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointADNP(49518554)-SYCP2(58468648), # samples:3
Anticipated loss of major functional domain due to fusion event.ADNP-SYCP2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ADNP-SYCP2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ADNP-SYCP2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ADNP-SYCP2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ADNP-SYCP2 seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor due to the frame-shifted ORF.
ADNP-SYCP2 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
ADNP-SYCP2 seems lost the major protein functional domain in Hgene partner, which is a transcription factor due to the frame-shifted ORF.
ADNP-SYCP2 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across ADNP (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across SYCP2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-A1-A0SJ-01AADNPchr20

49518554

-SYCP2chr20

58468648

-


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Fusion Gene ORF analysis for ADNP-SYCP2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000349014ENST00000476314ADNPchr20

49518554

-SYCP2chr20

58468648

-
5CDS-intronENST00000371602ENST00000476314ADNPchr20

49518554

-SYCP2chr20

58468648

-
5CDS-intronENST00000396029ENST00000476314ADNPchr20

49518554

-SYCP2chr20

58468648

-
5CDS-intronENST00000396032ENST00000476314ADNPchr20

49518554

-SYCP2chr20

58468648

-
Frame-shiftENST00000349014ENST00000357552ADNPchr20

49518554

-SYCP2chr20

58468648

-
Frame-shiftENST00000349014ENST00000371001ADNPchr20

49518554

-SYCP2chr20

58468648

-
Frame-shiftENST00000396032ENST00000357552ADNPchr20

49518554

-SYCP2chr20

58468648

-
Frame-shiftENST00000396032ENST00000371001ADNPchr20

49518554

-SYCP2chr20

58468648

-
In-frameENST00000371602ENST00000357552ADNPchr20

49518554

-SYCP2chr20

58468648

-
In-frameENST00000371602ENST00000371001ADNPchr20

49518554

-SYCP2chr20

58468648

-
In-frameENST00000396029ENST00000357552ADNPchr20

49518554

-SYCP2chr20

58468648

-
In-frameENST00000396029ENST00000371001ADNPchr20

49518554

-SYCP2chr20

58468648

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000396029ADNPchr2049518554-ENST00000357552SYCP2chr2058468648-444576949036961068
ENST00000396029ADNPchr2049518554-ENST00000371001SYCP2chr2058468648-444276949036961068
ENST00000371602ADNPchr2049518554-ENST00000357552SYCP2chr2058468648-419752132034481042
ENST00000371602ADNPchr2049518554-ENST00000371001SYCP2chr2058468648-419452132034481042

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000396029ENST00000357552ADNPchr2049518554-SYCP2chr2058468648-0.0006446380.9993554
ENST00000396029ENST00000371001ADNPchr2049518554-SYCP2chr2058468648-0.0006491640.99935085
ENST00000371602ENST00000357552ADNPchr2049518554-SYCP2chr2058468648-0.0005019280.999498
ENST00000371602ENST00000371001ADNPchr2049518554-SYCP2chr2058468648-0.0005075080.9994925

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Fusion Genomic Features for ADNP-SYCP2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for ADNP-SYCP2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr20:49518554/chr20:58468648)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneSYCP2chr20:49518554chr20:58468648ENST000003575521945655_6605551531.0Compositional biasNote=Poly-Ser
TgeneSYCP2chr20:49518554chr20:58468648ENST000003710011844655_6605551531.0Compositional biasNote=Poly-Ser

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneADNPchr20:49518554chr20:58468648ENST00000349014-34754_814671103.0DNA bindingHomeobox
HgeneADNPchr20:49518554chr20:58468648ENST00000371602-23754_814671103.0DNA bindingHomeobox
HgeneADNPchr20:49518554chr20:58468648ENST00000396029-45754_814671103.0DNA bindingHomeobox
HgeneADNPchr20:49518554chr20:58468648ENST00000396032-34754_814671103.0DNA bindingHomeobox
HgeneADNPchr20:49518554chr20:58468648ENST00000349014-34354_361671103.0RegionNeuroprotective peptide (NAP)
HgeneADNPchr20:49518554chr20:58468648ENST00000371602-23354_361671103.0RegionNeuroprotective peptide (NAP)
HgeneADNPchr20:49518554chr20:58468648ENST00000396029-45354_361671103.0RegionNeuroprotective peptide (NAP)
HgeneADNPchr20:49518554chr20:58468648ENST00000396032-34354_361671103.0RegionNeuroprotective peptide (NAP)
HgeneADNPchr20:49518554chr20:58468648ENST00000349014-34107_129671103.0Zinc fingerC2H2-type 2%3B atypical
HgeneADNPchr20:49518554chr20:58468648ENST00000349014-34165_188671103.0Zinc fingerC2H2-type 3
HgeneADNPchr20:49518554chr20:58468648ENST00000349014-34221_244671103.0Zinc fingerC2H2-type 4
HgeneADNPchr20:49518554chr20:58468648ENST00000349014-34447_469671103.0Zinc fingerC2H2-type 5%3B atypical
HgeneADNPchr20:49518554chr20:58468648ENST00000349014-34489_510671103.0Zinc fingerC2H2-type 6%3B atypical
HgeneADNPchr20:49518554chr20:58468648ENST00000349014-34512_535671103.0Zinc fingerC2H2-type 7
HgeneADNPchr20:49518554chr20:58468648ENST00000349014-34622_647671103.0Zinc fingerC2H2-type 8%3B atypical
HgeneADNPchr20:49518554chr20:58468648ENST00000349014-34662_686671103.0Zinc fingerC2H2-type 9%3B atypical
HgeneADNPchr20:49518554chr20:58468648ENST00000349014-3474_97671103.0Zinc fingerC2H2-type 1
HgeneADNPchr20:49518554chr20:58468648ENST00000371602-23107_129671103.0Zinc fingerC2H2-type 2%3B atypical
HgeneADNPchr20:49518554chr20:58468648ENST00000371602-23165_188671103.0Zinc fingerC2H2-type 3
HgeneADNPchr20:49518554chr20:58468648ENST00000371602-23221_244671103.0Zinc fingerC2H2-type 4
HgeneADNPchr20:49518554chr20:58468648ENST00000371602-23447_469671103.0Zinc fingerC2H2-type 5%3B atypical
HgeneADNPchr20:49518554chr20:58468648ENST00000371602-23489_510671103.0Zinc fingerC2H2-type 6%3B atypical
HgeneADNPchr20:49518554chr20:58468648ENST00000371602-23512_535671103.0Zinc fingerC2H2-type 7
HgeneADNPchr20:49518554chr20:58468648ENST00000371602-23622_647671103.0Zinc fingerC2H2-type 8%3B atypical
HgeneADNPchr20:49518554chr20:58468648ENST00000371602-23662_686671103.0Zinc fingerC2H2-type 9%3B atypical
HgeneADNPchr20:49518554chr20:58468648ENST00000371602-2374_97671103.0Zinc fingerC2H2-type 1
HgeneADNPchr20:49518554chr20:58468648ENST00000396029-45107_129671103.0Zinc fingerC2H2-type 2%3B atypical
HgeneADNPchr20:49518554chr20:58468648ENST00000396029-45165_188671103.0Zinc fingerC2H2-type 3
HgeneADNPchr20:49518554chr20:58468648ENST00000396029-45221_244671103.0Zinc fingerC2H2-type 4
HgeneADNPchr20:49518554chr20:58468648ENST00000396029-45447_469671103.0Zinc fingerC2H2-type 5%3B atypical
HgeneADNPchr20:49518554chr20:58468648ENST00000396029-45489_510671103.0Zinc fingerC2H2-type 6%3B atypical
HgeneADNPchr20:49518554chr20:58468648ENST00000396029-45512_535671103.0Zinc fingerC2H2-type 7
HgeneADNPchr20:49518554chr20:58468648ENST00000396029-45622_647671103.0Zinc fingerC2H2-type 8%3B atypical
HgeneADNPchr20:49518554chr20:58468648ENST00000396029-45662_686671103.0Zinc fingerC2H2-type 9%3B atypical
HgeneADNPchr20:49518554chr20:58468648ENST00000396029-4574_97671103.0Zinc fingerC2H2-type 1
HgeneADNPchr20:49518554chr20:58468648ENST00000396032-34107_129671103.0Zinc fingerC2H2-type 2%3B atypical
HgeneADNPchr20:49518554chr20:58468648ENST00000396032-34165_188671103.0Zinc fingerC2H2-type 3
HgeneADNPchr20:49518554chr20:58468648ENST00000396032-34221_244671103.0Zinc fingerC2H2-type 4
HgeneADNPchr20:49518554chr20:58468648ENST00000396032-34447_469671103.0Zinc fingerC2H2-type 5%3B atypical
HgeneADNPchr20:49518554chr20:58468648ENST00000396032-34489_510671103.0Zinc fingerC2H2-type 6%3B atypical
HgeneADNPchr20:49518554chr20:58468648ENST00000396032-34512_535671103.0Zinc fingerC2H2-type 7
HgeneADNPchr20:49518554chr20:58468648ENST00000396032-34622_647671103.0Zinc fingerC2H2-type 8%3B atypical
HgeneADNPchr20:49518554chr20:58468648ENST00000396032-34662_686671103.0Zinc fingerC2H2-type 9%3B atypical
HgeneADNPchr20:49518554chr20:58468648ENST00000396032-3474_97671103.0Zinc fingerC2H2-type 1


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Fusion Gene Sequence for ADNP-SYCP2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>2512_2512_1_ADNP-SYCP2_ADNP_chr20_49518554_ENST00000371602_SYCP2_chr20_58468648_ENST00000357552_length(transcript)=4197nt_BP=521nt
TTGAGCCCAGAAGGTTGAGGCTATGGTGAATCGTGAGTGCACTGCAGTCAATGAACCATGAGTGCACTGCACTCCAGCCTGCGCGACAGA
GTAAGACTCTGTCTTAAGAAAAGGAAGGAAGGATGGATGGATGGATATATCAAGCCATATGCACATGAAAGCAGGTGTGTGTCTGTGTGT
GTACACACTAGATGAGGATATCTATGCACCTTTTTTGTCAGATGGGTAGGTTTTATGATCCTATCATCAGTGGAATTAGTAAATATTACA
AGTTGTACGTGTTTTGACTTTGACTTAAATTTTTTTTTCCAATAGAAACTATGTTCCAACTTCCTGTCAACAATCTTGGCAGTTTAAGAA
AAGCCCGGAAAACTGTGAAAAAAATACTTAGTGACATTGGGTTGGAATACTGTAAAGAACATATAGAAGATTTTAAACAATTTGAACCTA
ATGACTTTTATTTGAAAAACACTACATGGGAGGATGTAGGACTGTGGGACCCATCACTTACGAAAAACCAGCATATCAAAACTGCTAAGT
GTGTAGAAAACACAGAAAATAAGAATGTTGAATTCCCAAACCAAAATTTTAGTGAACTCCAGGATGTTATACCAGATTCACAGGCAGCGG
AAAAAAGAGATCATACTATATTACCTGGTGTTTTAGACAACATCTGTGGAAATAAAATACACAGCAAATGGGCATGTTGGACACCTGTAA
CAAACATTGAACTATGTAATAACCAAAGAGCAAGTACTTCGTCAGGAGACACATTGAATCAAGATATTGTTATAAATAAAAAACTTACTA
AACAAAAATCATCCTCTTCAATATCTGATCATAATTCTGAAGGAACAGGAAAAGTGAAATATAAGAAAGAACAAACCGACCATATCAAAA
TAGATAAAGCAGAAGTAGAAGTTTGCAAGAAACACAATCAGCAACAAAATCATCCTAAATATTCAGGGCAGAAAAATACTGAAAATGCCA
AGCAGAGTGATTGGCCTGTTGAATCTGAAACTACTTTTAAATCGGTTCTCCTAAATAAGACAATTGAAGAATCGCTGATATATAGGAAGA
AATACATATTGTCAAAAGATGTGAATACTGCTACTTGCGATAAAAATCCATCTGCTAGCAAAAATGTGCAAAGTCATAGAAAAGCAGAGA
AAGAATTGACTTCTGAGCTTAATTCCTGGGATTCGAAACAAAAAAAAATGAGAGAAAAGTCAAAAGGGAAAGAATTTACCAATGTAGCAG
AATCCTTGATAAGCCAAATCAATAAAAGATACAAAACAAAAGATGACATCAAGTCTACAAGAAAATTAAAGGAGTCTTTGATTAACAGTG
GTTTTTCAAACAAACCTGTTGTACAACTCAGTAAGGAAAAAGTTCAGAAAAAAAGCTACAGAAAACTGAAGACTACCTTTGTTAATGTTA
CTTCTGAATGCCCAGTGAATGATGTTTACAATTTTAATTTGAATGGAGCTGATGACCCTATCATAAAACTTGGAATCCAAGAGTTTCAAG
CTACAGCTAAAGAAGCTTGTGCGGATAGGTCAATTAGATTGGTAGGTCCAAGGAATCATGATGAACTTAAATCTTCTGTCAAAACAAAAG
ATAAAAAAATTATAACAAATCATCAAAAGAAAAATCTGTTTAGTGATACTGAAACAGAGTACAGATGTGATGACAGCAAGACTGATATTA
GCTGGCTAAGAGAACCGAAATCAAAACCACAGCTAATAGACTATAGCAGAAATAAAAATGTGAAGAATCATAAAAGTGGAAAATCAAGAT
CATCCTTGGAAAAGGGACAGCCAAGCTCTAAAATGACACCCAGTAAAAATATCACAAAAAAGATGGACAAGACAATTCCGGAAGGAAGAA
TCAGACTTCCACGAAAAGCAACCAAAACAAAAAAAAACTATAAAGATCTCTCAAATTCAGAATCAGAGTGTGAACAAGAATTTTCACATT
CATTTAAAGAGAACATACCAGTAAAGGAGGAGAATATCCATTCCAGAATGAAAACGGTAAAGCTACCAAAGAAACAACAGAAAGTCTTCT
GTGCTGAAACAGAAAAGGAACTATCAAAACAATGGAAAAACTCATCTCTACTAAAAGATGCTATACGAGATAATTGCCTTGACTTATCTC
CCAGATCTTTATCTGGCAGTCCATCATCTATAGAAGTAACGAGATGTATAGAGAAAATAACAGAAAAGGATTTTACTCAGGATTATGACT
GCATAACAAAATCTATATCACCTTATCCAAAAACTTCATCACTTGAATCCTTAAATAGTAACAGTGGAGTTGGAGGTACAATAAAGTCAC
CCAAAAACAATGAGAAAAACTTCCTGTGTGCAAGTGAAAGTTGTTCACCAATTCCACGACCACTGTTTTTGCCCAGACATACTCCAACTA
AGAGTAATACTATTGTAAATAGAAAAAAAATAAGTTCTCTGGTACTTACACAAGAAACACAAAACAGTAACAGCTATTCAGATGTAAGCA
GTTATAGTTCAGAAGAACGGTTTATGGAAATTGAATCTCCACATATCAATGAAAATTATATACAAAGCAAAAGAGAGGAAAGTCATTTAG
CATCTTCATTATCCAAGTCTAGTGAAGGAAGAGAGAAAACGTGGTTTGACATGCCCTGTGATGCTACTCATGTATCAGGCCCCACCCAAC
ATCTTAGTCGCAAAAGAATATATATAGAAGATAATCTAAGTAATTCCAATGAAGTAGAAATGGAAGAGAAAGGAGAAAGGAGAGCAAACT
TGCTTCCCAAAAAACTGTGTAAAATTGAAGATGCAGATCATCATATCCACAAAATGTCTGAAAGTGTATCTTCATTATCAACAAATGACT
TTTCTATTCCTTGGGAGACCTGGCAAAATGAATTTGCAGGGATAGAGATGACTTATGAGACTTACGAGAGGCTCAATTCAGAATTTAAGA
GAAGGAATAATATCCGACATAAAATGTTGAGTTATTTTACTACGCAGTCTTGGAAAACAGCTCAGCAACATCTGAGAACAATGAATCATC
AAAGTCAGGACTCTAGGATTAAAAAACTTGATAAATTCCAATTCATTATCATAGAGGAGCTGGAGAATTTTGAAAAAGATTCACAGTCTT
TAAAAGATTTGGAAAAGGAATTTGTGGACTTTTGGGAAAAGATATTTCAGAAGTTCAGTGCATATCAAAAAAGCGAACAACAGAGGCTTC
ATCTTTTGAAAACTTCATTGGCTAAAAGTGTCTTCTGTAATACTGATAGTGAAGAAACTGTTTTTACATCCGAGATGTGTTTGATGAAAG
AAGATATGAAAGTGCTGCAAGACAGGCTTCTTAAGGACATGCTAGAAGAGGAGCTTCTTAATGTACGCAGAGAACTGATGTCAGTATTCA
TGTCTCATGAAAGAAATGCTAATGTGTGAAATCTAGTTTTTATCACCATACTTTATCTAATTATTATTCTCTGTATATAACTGAGGAAAT
AAGAATAGTCCTACAAAGAGAAAAATATACATGTCACCGAAGCAAGTGTACCCTTTATAGGAACCCTCAAATTAAAAAAAAATGTCTTTT
AATGGATGAGAGGGAACCACTATAACATGAGTCCAAGCCCAGAAGACTTCTGTCTATACAATATTTTTTTTTAATTTTGGAGATAAAAGC
TTTAAGAAACTTTTTGAGTTAATTATACTCATAAAATGAGTTTCTTTAATAAATTAAATTTTATTGTGTAAAATGTATTATTACATAAAA
TGTGTTTTTGAATCAATGCAGTTTGGGGATGAATATAATTAAAATATGTTTAATAACTTAGAATTCAACTAATAAAAATTTAGCCACACT
TACAAGGGGGAGGAAGTCCCTAGTTTAAAATGTATAACTGAGTGGTAGATCAGTACTTTCAGCACACTGTTGGAAACATTTATTCAGATA
TGGCTCTAATGTATTAGGAAGCACTAAATGGCCTAAAAAAGCTACTACATTGCCTAAATATGTTAATTCAATATAGAAGTCCTATTTCAT
AACCAGGCTGTTTGACAAATACTTTTAATCTAGTAGTCATTGTAATATCTTGCTAGATTAATTTATAAAAATGAGTATACATTTGATTTG
CTTTTAATGAAGTTGAAATAAATGCTTATGTCACTTGAATAAATATAAATCATTATA

>2512_2512_1_ADNP-SYCP2_ADNP_chr20_49518554_ENST00000371602_SYCP2_chr20_58468648_ENST00000357552_length(amino acids)=1042AA_BP=66
MFQLPVNNLGSLRKARKTVKKILSDIGLEYCKEHIEDFKQFEPNDFYLKNTTWEDVGLWDPSLTKNQHIKTAKCVENTENKNVEFPNQNF
SELQDVIPDSQAAEKRDHTILPGVLDNICGNKIHSKWACWTPVTNIELCNNQRASTSSGDTLNQDIVINKKLTKQKSSSSISDHNSEGTG
KVKYKKEQTDHIKIDKAEVEVCKKHNQQQNHPKYSGQKNTENAKQSDWPVESETTFKSVLLNKTIEESLIYRKKYILSKDVNTATCDKNP
SASKNVQSHRKAEKELTSELNSWDSKQKKMREKSKGKEFTNVAESLISQINKRYKTKDDIKSTRKLKESLINSGFSNKPVVQLSKEKVQK
KSYRKLKTTFVNVTSECPVNDVYNFNLNGADDPIIKLGIQEFQATAKEACADRSIRLVGPRNHDELKSSVKTKDKKIITNHQKKNLFSDT
ETEYRCDDSKTDISWLREPKSKPQLIDYSRNKNVKNHKSGKSRSSLEKGQPSSKMTPSKNITKKMDKTIPEGRIRLPRKATKTKKNYKDL
SNSESECEQEFSHSFKENIPVKEENIHSRMKTVKLPKKQQKVFCAETEKELSKQWKNSSLLKDAIRDNCLDLSPRSLSGSPSSIEVTRCI
EKITEKDFTQDYDCITKSISPYPKTSSLESLNSNSGVGGTIKSPKNNEKNFLCASESCSPIPRPLFLPRHTPTKSNTIVNRKKISSLVLT
QETQNSNSYSDVSSYSSEERFMEIESPHINENYIQSKREESHLASSLSKSSEGREKTWFDMPCDATHVSGPTQHLSRKRIYIEDNLSNSN
EVEMEEKGERRANLLPKKLCKIEDADHHIHKMSESVSSLSTNDFSIPWETWQNEFAGIEMTYETYERLNSEFKRRNNIRHKMLSYFTTQS
WKTAQQHLRTMNHQSQDSRIKKLDKFQFIIIEELENFEKDSQSLKDLEKEFVDFWEKIFQKFSAYQKSEQQRLHLLKTSLAKSVFCNTDS
EETVFTSEMCLMKEDMKVLQDRLLKDMLEEELLNVRRELMSVFMSHERNANV

--------------------------------------------------------------
>2512_2512_2_ADNP-SYCP2_ADNP_chr20_49518554_ENST00000371602_SYCP2_chr20_58468648_ENST00000371001_length(transcript)=4194nt_BP=521nt
TTGAGCCCAGAAGGTTGAGGCTATGGTGAATCGTGAGTGCACTGCAGTCAATGAACCATGAGTGCACTGCACTCCAGCCTGCGCGACAGA
GTAAGACTCTGTCTTAAGAAAAGGAAGGAAGGATGGATGGATGGATATATCAAGCCATATGCACATGAAAGCAGGTGTGTGTCTGTGTGT
GTACACACTAGATGAGGATATCTATGCACCTTTTTTGTCAGATGGGTAGGTTTTATGATCCTATCATCAGTGGAATTAGTAAATATTACA
AGTTGTACGTGTTTTGACTTTGACTTAAATTTTTTTTTCCAATAGAAACTATGTTCCAACTTCCTGTCAACAATCTTGGCAGTTTAAGAA
AAGCCCGGAAAACTGTGAAAAAAATACTTAGTGACATTGGGTTGGAATACTGTAAAGAACATATAGAAGATTTTAAACAATTTGAACCTA
ATGACTTTTATTTGAAAAACACTACATGGGAGGATGTAGGACTGTGGGACCCATCACTTACGAAAAACCAGCATATCAAAACTGCTAAGT
GTGTAGAAAACACAGAAAATAAGAATGTTGAATTCCCAAACCAAAATTTTAGTGAACTCCAGGATGTTATACCAGATTCACAGGCAGCGG
AAAAAAGAGATCATACTATATTACCTGGTGTTTTAGACAACATCTGTGGAAATAAAATACACAGCAAATGGGCATGTTGGACACCTGTAA
CAAACATTGAACTATGTAATAACCAAAGAGCAAGTACTTCGTCAGGAGACACATTGAATCAAGATATTGTTATAAATAAAAAACTTACTA
AACAAAAATCATCCTCTTCAATATCTGATCATAATTCTGAAGGAACAGGAAAAGTGAAATATAAGAAAGAACAAACCGACCATATCAAAA
TAGATAAAGCAGAAGTAGAAGTTTGCAAGAAACACAATCAGCAACAAAATCATCCTAAATATTCAGGGCAGAAAAATACTGAAAATGCCA
AGCAGAGTGATTGGCCTGTTGAATCTGAAACTACTTTTAAATCGGTTCTCCTAAATAAGACAATTGAAGAATCGCTGATATATAGGAAGA
AATACATATTGTCAAAAGATGTGAATACTGCTACTTGCGATAAAAATCCATCTGCTAGCAAAAATGTGCAAAGTCATAGAAAAGCAGAGA
AAGAATTGACTTCTGAGCTTAATTCCTGGGATTCGAAACAAAAAAAAATGAGAGAAAAGTCAAAAGGGAAAGAATTTACCAATGTAGCAG
AATCCTTGATAAGCCAAATCAATAAAAGATACAAAACAAAAGATGACATCAAGTCTACAAGAAAATTAAAGGAGTCTTTGATTAACAGTG
GTTTTTCAAACAAACCTGTTGTACAACTCAGTAAGGAAAAAGTTCAGAAAAAAAGCTACAGAAAACTGAAGACTACCTTTGTTAATGTTA
CTTCTGAATGCCCAGTGAATGATGTTTACAATTTTAATTTGAATGGAGCTGATGACCCTATCATAAAACTTGGAATCCAAGAGTTTCAAG
CTACAGCTAAAGAAGCTTGTGCGGATAGGTCAATTAGATTGGTAGGTCCAAGGAATCATGATGAACTTAAATCTTCTGTCAAAACAAAAG
ATAAAAAAATTATAACAAATCATCAAAAGAAAAATCTGTTTAGTGATACTGAAACAGAGTACAGATGTGATGACAGCAAGACTGATATTA
GCTGGCTAAGAGAACCGAAATCAAAACCACAGCTAATAGACTATAGCAGAAATAAAAATGTGAAGAATCATAAAAGTGGAAAATCAAGAT
CATCCTTGGAAAAGGGACAGCCAAGCTCTAAAATGACACCCAGTAAAAATATCACAAAAAAGATGGACAAGACAATTCCGGAAGGAAGAA
TCAGACTTCCACGAAAAGCAACCAAAACAAAAAAAAACTATAAAGATCTCTCAAATTCAGAATCAGAGTGTGAACAAGAATTTTCACATT
CATTTAAAGAGAACATACCAGTAAAGGAGGAGAATATCCATTCCAGAATGAAAACGGTAAAGCTACCAAAGAAACAACAGAAAGTCTTCT
GTGCTGAAACAGAAAAGGAACTATCAAAACAATGGAAAAACTCATCTCTACTAAAAGATGCTATACGAGATAATTGCCTTGACTTATCTC
CCAGATCTTTATCTGGCAGTCCATCATCTATAGAAGTAACGAGATGTATAGAGAAAATAACAGAAAAGGATTTTACTCAGGATTATGACT
GCATAACAAAATCTATATCACCTTATCCAAAAACTTCATCACTTGAATCCTTAAATAGTAACAGTGGAGTTGGAGGTACAATAAAGTCAC
CCAAAAACAATGAGAAAAACTTCCTGTGTGCAAGTGAAAGTTGTTCACCAATTCCACGACCACTGTTTTTGCCCAGACATACTCCAACTA
AGAGTAATACTATTGTAAATAGAAAAAAAATAAGTTCTCTGGTACTTACACAAGAAACACAAAACAGTAACAGCTATTCAGATGTAAGCA
GTTATAGTTCAGAAGAACGGTTTATGGAAATTGAATCTCCACATATCAATGAAAATTATATACAAAGCAAAAGAGAGGAAAGTCATTTAG
CATCTTCATTATCCAAGTCTAGTGAAGGAAGAGAGAAAACGTGGTTTGACATGCCCTGTGATGCTACTCATGTATCAGGCCCCACCCAAC
ATCTTAGTCGCAAAAGAATATATATAGAAGATAATCTAAGTAATTCCAATGAAGTAGAAATGGAAGAGAAAGGAGAAAGGAGAGCAAACT
TGCTTCCCAAAAAACTGTGTAAAATTGAAGATGCAGATCATCATATCCACAAAATGTCTGAAAGTGTATCTTCATTATCAACAAATGACT
TTTCTATTCCTTGGGAGACCTGGCAAAATGAATTTGCAGGGATAGAGATGACTTATGAGACTTACGAGAGGCTCAATTCAGAATTTAAGA
GAAGGAATAATATCCGACATAAAATGTTGAGTTATTTTACTACGCAGTCTTGGAAAACAGCTCAGCAACATCTGAGAACAATGAATCATC
AAAGTCAGGACTCTAGGATTAAAAAACTTGATAAATTCCAATTCATTATCATAGAGGAGCTGGAGAATTTTGAAAAAGATTCACAGTCTT
TAAAAGATTTGGAAAAGGAATTTGTGGACTTTTGGGAAAAGATATTTCAGAAGTTCAGTGCATATCAAAAAAGCGAACAACAGAGGCTTC
ATCTTTTGAAAACTTCATTGGCTAAAAGTGTCTTCTGTAATACTGATAGTGAAGAAACTGTTTTTACATCCGAGATGTGTTTGATGAAAG
AAGATATGAAAGTGCTGCAAGACAGGCTTCTTAAGGACATGCTAGAAGAGGAGCTTCTTAATGTACGCAGAGAACTGATGTCAGTATTCA
TGTCTCATGAAAGAAATGCTAATGTGTGAAATCTAGTTTTTATCACCATACTTTATCTAATTATTATTCTCTGTATATAACTGAGGAAAT
AAGAATAGTCCTACAAAGAGAAAAATATACATGTCACCGAAGCAAGTGTACCCTTTATAGGAACCCTCAAATTAAAAAAAAATGTCTTTT
AATGGATGAGAGGGAACCACTATAACATGAGTCCAAGCCCAGAAGACTTCTGTCTATACAATATTTTTTTTTAATTTTGGAGATAAAAGC
TTTAAGAAACTTTTTGAGTTAATTATACTCATAAAATGAGTTTCTTTAATAAATTAAATTTTATTGTGTAAAATGTATTATTACATAAAA
TGTGTTTTTGAATCAATGCAGTTTGGGGATGAATATAATTAAAATATGTTTAATAACTTAGAATTCAACTAATAAAAATTTAGCCACACT
TACAAGGGGGAGGAAGTCCCTAGTTTAAAATGTATAACTGAGTGGTAGATCAGTACTTTCAGCACACTGTTGGAAACATTTATTCAGATA
TGGCTCTAATGTATTAGGAAGCACTAAATGGCCTAAAAAAGCTACTACATTGCCTAAATATGTTAATTCAATATAGAAGTCCTATTTCAT
AACCAGGCTGTTTGACAAATACTTTTAATCTAGTAGTCATTGTAATATCTTGCTAGATTAATTTATAAAAATGAGTATACATTTGATTTG
CTTTTAATGAAGTTGAAATAAATGCTTATGTCACTTGAATAAATATAAATCATT

>2512_2512_2_ADNP-SYCP2_ADNP_chr20_49518554_ENST00000371602_SYCP2_chr20_58468648_ENST00000371001_length(amino acids)=1042AA_BP=66
MFQLPVNNLGSLRKARKTVKKILSDIGLEYCKEHIEDFKQFEPNDFYLKNTTWEDVGLWDPSLTKNQHIKTAKCVENTENKNVEFPNQNF
SELQDVIPDSQAAEKRDHTILPGVLDNICGNKIHSKWACWTPVTNIELCNNQRASTSSGDTLNQDIVINKKLTKQKSSSSISDHNSEGTG
KVKYKKEQTDHIKIDKAEVEVCKKHNQQQNHPKYSGQKNTENAKQSDWPVESETTFKSVLLNKTIEESLIYRKKYILSKDVNTATCDKNP
SASKNVQSHRKAEKELTSELNSWDSKQKKMREKSKGKEFTNVAESLISQINKRYKTKDDIKSTRKLKESLINSGFSNKPVVQLSKEKVQK
KSYRKLKTTFVNVTSECPVNDVYNFNLNGADDPIIKLGIQEFQATAKEACADRSIRLVGPRNHDELKSSVKTKDKKIITNHQKKNLFSDT
ETEYRCDDSKTDISWLREPKSKPQLIDYSRNKNVKNHKSGKSRSSLEKGQPSSKMTPSKNITKKMDKTIPEGRIRLPRKATKTKKNYKDL
SNSESECEQEFSHSFKENIPVKEENIHSRMKTVKLPKKQQKVFCAETEKELSKQWKNSSLLKDAIRDNCLDLSPRSLSGSPSSIEVTRCI
EKITEKDFTQDYDCITKSISPYPKTSSLESLNSNSGVGGTIKSPKNNEKNFLCASESCSPIPRPLFLPRHTPTKSNTIVNRKKISSLVLT
QETQNSNSYSDVSSYSSEERFMEIESPHINENYIQSKREESHLASSLSKSSEGREKTWFDMPCDATHVSGPTQHLSRKRIYIEDNLSNSN
EVEMEEKGERRANLLPKKLCKIEDADHHIHKMSESVSSLSTNDFSIPWETWQNEFAGIEMTYETYERLNSEFKRRNNIRHKMLSYFTTQS
WKTAQQHLRTMNHQSQDSRIKKLDKFQFIIIEELENFEKDSQSLKDLEKEFVDFWEKIFQKFSAYQKSEQQRLHLLKTSLAKSVFCNTDS
EETVFTSEMCLMKEDMKVLQDRLLKDMLEEELLNVRRELMSVFMSHERNANV

--------------------------------------------------------------
>2512_2512_3_ADNP-SYCP2_ADNP_chr20_49518554_ENST00000396029_SYCP2_chr20_58468648_ENST00000357552_length(transcript)=4445nt_BP=769nt
GCAGCGCTAAGGGGGATTTTGGCGTCTTCTCAGACACAGCTCCCTCTCTCGGTCCCCGCTGCTGAGGAGCGAGAGGAGCGCGGCCGCCGC
CGCCCGCGCCGGTGAAGCCGCCTCTCCCACACCCTCCGTCTCCTCCCTCCGCCCCTCCTTTGTCTGCACCGCTCGACGACGCCGCCGCCG
CCCGCCGCTCTGCTGCGCCCGCCGCGCCCCCCGGCAGCACCCGCGGCCGCGGCGCGAGCCGGAGTCCGCCGAGCCGGAGCGCGACGAGGC
CCCGGGCGCGCCCTCCCCGCTGCCGCCACCGCCGTGCCGCCGCCATCCGCCCGCCGCCGCCGCCGCTGTCCGGCCCCCGAGCACGCCGGC
CCCGCGCGCGCCTCGAGGCCGAGTCAAGGTGTGAGATGCACAATGCGAAACCTAGGCCCCAGCTTTTACACCATGATGCGCAGGGTTGTA
CTTTTTGTACTGAACTGATAGGTGGCCTAGTGGTTATGCCCTGTACTACCATTTTGAGGATCTGGACTCCGTTTCCTGCCTTGCTCTTTG
GACCACATTGTCAATTCACACCGAAACTATGTTCCAACTTCCTGTCAACAATCTTGGCAGTTTAAGAAAAGCCCGGAAAACTGTGAAAAA
AATACTTAGTGACATTGGGTTGGAATACTGTAAAGAACATATAGAAGATTTTAAACAATTTGAACCTAATGACTTTTATTTGAAAAACAC
TACATGGGAGGATGTAGGACTGTGGGACCCATCACTTACGAAAAACCAGCATATCAAAACTGCTAAGTGTGTAGAAAACACAGAAAATAA
GAATGTTGAATTCCCAAACCAAAATTTTAGTGAACTCCAGGATGTTATACCAGATTCACAGGCAGCGGAAAAAAGAGATCATACTATATT
ACCTGGTGTTTTAGACAACATCTGTGGAAATAAAATACACAGCAAATGGGCATGTTGGACACCTGTAACAAACATTGAACTATGTAATAA
CCAAAGAGCAAGTACTTCGTCAGGAGACACATTGAATCAAGATATTGTTATAAATAAAAAACTTACTAAACAAAAATCATCCTCTTCAAT
ATCTGATCATAATTCTGAAGGAACAGGAAAAGTGAAATATAAGAAAGAACAAACCGACCATATCAAAATAGATAAAGCAGAAGTAGAAGT
TTGCAAGAAACACAATCAGCAACAAAATCATCCTAAATATTCAGGGCAGAAAAATACTGAAAATGCCAAGCAGAGTGATTGGCCTGTTGA
ATCTGAAACTACTTTTAAATCGGTTCTCCTAAATAAGACAATTGAAGAATCGCTGATATATAGGAAGAAATACATATTGTCAAAAGATGT
GAATACTGCTACTTGCGATAAAAATCCATCTGCTAGCAAAAATGTGCAAAGTCATAGAAAAGCAGAGAAAGAATTGACTTCTGAGCTTAA
TTCCTGGGATTCGAAACAAAAAAAAATGAGAGAAAAGTCAAAAGGGAAAGAATTTACCAATGTAGCAGAATCCTTGATAAGCCAAATCAA
TAAAAGATACAAAACAAAAGATGACATCAAGTCTACAAGAAAATTAAAGGAGTCTTTGATTAACAGTGGTTTTTCAAACAAACCTGTTGT
ACAACTCAGTAAGGAAAAAGTTCAGAAAAAAAGCTACAGAAAACTGAAGACTACCTTTGTTAATGTTACTTCTGAATGCCCAGTGAATGA
TGTTTACAATTTTAATTTGAATGGAGCTGATGACCCTATCATAAAACTTGGAATCCAAGAGTTTCAAGCTACAGCTAAAGAAGCTTGTGC
GGATAGGTCAATTAGATTGGTAGGTCCAAGGAATCATGATGAACTTAAATCTTCTGTCAAAACAAAAGATAAAAAAATTATAACAAATCA
TCAAAAGAAAAATCTGTTTAGTGATACTGAAACAGAGTACAGATGTGATGACAGCAAGACTGATATTAGCTGGCTAAGAGAACCGAAATC
AAAACCACAGCTAATAGACTATAGCAGAAATAAAAATGTGAAGAATCATAAAAGTGGAAAATCAAGATCATCCTTGGAAAAGGGACAGCC
AAGCTCTAAAATGACACCCAGTAAAAATATCACAAAAAAGATGGACAAGACAATTCCGGAAGGAAGAATCAGACTTCCACGAAAAGCAAC
CAAAACAAAAAAAAACTATAAAGATCTCTCAAATTCAGAATCAGAGTGTGAACAAGAATTTTCACATTCATTTAAAGAGAACATACCAGT
AAAGGAGGAGAATATCCATTCCAGAATGAAAACGGTAAAGCTACCAAAGAAACAACAGAAAGTCTTCTGTGCTGAAACAGAAAAGGAACT
ATCAAAACAATGGAAAAACTCATCTCTACTAAAAGATGCTATACGAGATAATTGCCTTGACTTATCTCCCAGATCTTTATCTGGCAGTCC
ATCATCTATAGAAGTAACGAGATGTATAGAGAAAATAACAGAAAAGGATTTTACTCAGGATTATGACTGCATAACAAAATCTATATCACC
TTATCCAAAAACTTCATCACTTGAATCCTTAAATAGTAACAGTGGAGTTGGAGGTACAATAAAGTCACCCAAAAACAATGAGAAAAACTT
CCTGTGTGCAAGTGAAAGTTGTTCACCAATTCCACGACCACTGTTTTTGCCCAGACATACTCCAACTAAGAGTAATACTATTGTAAATAG
AAAAAAAATAAGTTCTCTGGTACTTACACAAGAAACACAAAACAGTAACAGCTATTCAGATGTAAGCAGTTATAGTTCAGAAGAACGGTT
TATGGAAATTGAATCTCCACATATCAATGAAAATTATATACAAAGCAAAAGAGAGGAAAGTCATTTAGCATCTTCATTATCCAAGTCTAG
TGAAGGAAGAGAGAAAACGTGGTTTGACATGCCCTGTGATGCTACTCATGTATCAGGCCCCACCCAACATCTTAGTCGCAAAAGAATATA
TATAGAAGATAATCTAAGTAATTCCAATGAAGTAGAAATGGAAGAGAAAGGAGAAAGGAGAGCAAACTTGCTTCCCAAAAAACTGTGTAA
AATTGAAGATGCAGATCATCATATCCACAAAATGTCTGAAAGTGTATCTTCATTATCAACAAATGACTTTTCTATTCCTTGGGAGACCTG
GCAAAATGAATTTGCAGGGATAGAGATGACTTATGAGACTTACGAGAGGCTCAATTCAGAATTTAAGAGAAGGAATAATATCCGACATAA
AATGTTGAGTTATTTTACTACGCAGTCTTGGAAAACAGCTCAGCAACATCTGAGAACAATGAATCATCAAAGTCAGGACTCTAGGATTAA
AAAACTTGATAAATTCCAATTCATTATCATAGAGGAGCTGGAGAATTTTGAAAAAGATTCACAGTCTTTAAAAGATTTGGAAAAGGAATT
TGTGGACTTTTGGGAAAAGATATTTCAGAAGTTCAGTGCATATCAAAAAAGCGAACAACAGAGGCTTCATCTTTTGAAAACTTCATTGGC
TAAAAGTGTCTTCTGTAATACTGATAGTGAAGAAACTGTTTTTACATCCGAGATGTGTTTGATGAAAGAAGATATGAAAGTGCTGCAAGA
CAGGCTTCTTAAGGACATGCTAGAAGAGGAGCTTCTTAATGTACGCAGAGAACTGATGTCAGTATTCATGTCTCATGAAAGAAATGCTAA
TGTGTGAAATCTAGTTTTTATCACCATACTTTATCTAATTATTATTCTCTGTATATAACTGAGGAAATAAGAATAGTCCTACAAAGAGAA
AAATATACATGTCACCGAAGCAAGTGTACCCTTTATAGGAACCCTCAAATTAAAAAAAAATGTCTTTTAATGGATGAGAGGGAACCACTA
TAACATGAGTCCAAGCCCAGAAGACTTCTGTCTATACAATATTTTTTTTTAATTTTGGAGATAAAAGCTTTAAGAAACTTTTTGAGTTAA
TTATACTCATAAAATGAGTTTCTTTAATAAATTAAATTTTATTGTGTAAAATGTATTATTACATAAAATGTGTTTTTGAATCAATGCAGT
TTGGGGATGAATATAATTAAAATATGTTTAATAACTTAGAATTCAACTAATAAAAATTTAGCCACACTTACAAGGGGGAGGAAGTCCCTA
GTTTAAAATGTATAACTGAGTGGTAGATCAGTACTTTCAGCACACTGTTGGAAACATTTATTCAGATATGGCTCTAATGTATTAGGAAGC
ACTAAATGGCCTAAAAAAGCTACTACATTGCCTAAATATGTTAATTCAATATAGAAGTCCTATTTCATAACCAGGCTGTTTGACAAATAC
TTTTAATCTAGTAGTCATTGTAATATCTTGCTAGATTAATTTATAAAAATGAGTATACATTTGATTTGCTTTTAATGAAGTTGAAATAAA
TGCTTATGTCACTTGAATAAATATAAATCATTATA

>2512_2512_3_ADNP-SYCP2_ADNP_chr20_49518554_ENST00000396029_SYCP2_chr20_58468648_ENST00000357552_length(amino acids)=1068AA_BP=92
MYYHFEDLDSVSCLALWTTLSIHTETMFQLPVNNLGSLRKARKTVKKILSDIGLEYCKEHIEDFKQFEPNDFYLKNTTWEDVGLWDPSLT
KNQHIKTAKCVENTENKNVEFPNQNFSELQDVIPDSQAAEKRDHTILPGVLDNICGNKIHSKWACWTPVTNIELCNNQRASTSSGDTLNQ
DIVINKKLTKQKSSSSISDHNSEGTGKVKYKKEQTDHIKIDKAEVEVCKKHNQQQNHPKYSGQKNTENAKQSDWPVESETTFKSVLLNKT
IEESLIYRKKYILSKDVNTATCDKNPSASKNVQSHRKAEKELTSELNSWDSKQKKMREKSKGKEFTNVAESLISQINKRYKTKDDIKSTR
KLKESLINSGFSNKPVVQLSKEKVQKKSYRKLKTTFVNVTSECPVNDVYNFNLNGADDPIIKLGIQEFQATAKEACADRSIRLVGPRNHD
ELKSSVKTKDKKIITNHQKKNLFSDTETEYRCDDSKTDISWLREPKSKPQLIDYSRNKNVKNHKSGKSRSSLEKGQPSSKMTPSKNITKK
MDKTIPEGRIRLPRKATKTKKNYKDLSNSESECEQEFSHSFKENIPVKEENIHSRMKTVKLPKKQQKVFCAETEKELSKQWKNSSLLKDA
IRDNCLDLSPRSLSGSPSSIEVTRCIEKITEKDFTQDYDCITKSISPYPKTSSLESLNSNSGVGGTIKSPKNNEKNFLCASESCSPIPRP
LFLPRHTPTKSNTIVNRKKISSLVLTQETQNSNSYSDVSSYSSEERFMEIESPHINENYIQSKREESHLASSLSKSSEGREKTWFDMPCD
ATHVSGPTQHLSRKRIYIEDNLSNSNEVEMEEKGERRANLLPKKLCKIEDADHHIHKMSESVSSLSTNDFSIPWETWQNEFAGIEMTYET
YERLNSEFKRRNNIRHKMLSYFTTQSWKTAQQHLRTMNHQSQDSRIKKLDKFQFIIIEELENFEKDSQSLKDLEKEFVDFWEKIFQKFSA
YQKSEQQRLHLLKTSLAKSVFCNTDSEETVFTSEMCLMKEDMKVLQDRLLKDMLEEELLNVRRELMSVFMSHERNANV

--------------------------------------------------------------
>2512_2512_4_ADNP-SYCP2_ADNP_chr20_49518554_ENST00000396029_SYCP2_chr20_58468648_ENST00000371001_length(transcript)=4442nt_BP=769nt
GCAGCGCTAAGGGGGATTTTGGCGTCTTCTCAGACACAGCTCCCTCTCTCGGTCCCCGCTGCTGAGGAGCGAGAGGAGCGCGGCCGCCGC
CGCCCGCGCCGGTGAAGCCGCCTCTCCCACACCCTCCGTCTCCTCCCTCCGCCCCTCCTTTGTCTGCACCGCTCGACGACGCCGCCGCCG
CCCGCCGCTCTGCTGCGCCCGCCGCGCCCCCCGGCAGCACCCGCGGCCGCGGCGCGAGCCGGAGTCCGCCGAGCCGGAGCGCGACGAGGC
CCCGGGCGCGCCCTCCCCGCTGCCGCCACCGCCGTGCCGCCGCCATCCGCCCGCCGCCGCCGCCGCTGTCCGGCCCCCGAGCACGCCGGC
CCCGCGCGCGCCTCGAGGCCGAGTCAAGGTGTGAGATGCACAATGCGAAACCTAGGCCCCAGCTTTTACACCATGATGCGCAGGGTTGTA
CTTTTTGTACTGAACTGATAGGTGGCCTAGTGGTTATGCCCTGTACTACCATTTTGAGGATCTGGACTCCGTTTCCTGCCTTGCTCTTTG
GACCACATTGTCAATTCACACCGAAACTATGTTCCAACTTCCTGTCAACAATCTTGGCAGTTTAAGAAAAGCCCGGAAAACTGTGAAAAA
AATACTTAGTGACATTGGGTTGGAATACTGTAAAGAACATATAGAAGATTTTAAACAATTTGAACCTAATGACTTTTATTTGAAAAACAC
TACATGGGAGGATGTAGGACTGTGGGACCCATCACTTACGAAAAACCAGCATATCAAAACTGCTAAGTGTGTAGAAAACACAGAAAATAA
GAATGTTGAATTCCCAAACCAAAATTTTAGTGAACTCCAGGATGTTATACCAGATTCACAGGCAGCGGAAAAAAGAGATCATACTATATT
ACCTGGTGTTTTAGACAACATCTGTGGAAATAAAATACACAGCAAATGGGCATGTTGGACACCTGTAACAAACATTGAACTATGTAATAA
CCAAAGAGCAAGTACTTCGTCAGGAGACACATTGAATCAAGATATTGTTATAAATAAAAAACTTACTAAACAAAAATCATCCTCTTCAAT
ATCTGATCATAATTCTGAAGGAACAGGAAAAGTGAAATATAAGAAAGAACAAACCGACCATATCAAAATAGATAAAGCAGAAGTAGAAGT
TTGCAAGAAACACAATCAGCAACAAAATCATCCTAAATATTCAGGGCAGAAAAATACTGAAAATGCCAAGCAGAGTGATTGGCCTGTTGA
ATCTGAAACTACTTTTAAATCGGTTCTCCTAAATAAGACAATTGAAGAATCGCTGATATATAGGAAGAAATACATATTGTCAAAAGATGT
GAATACTGCTACTTGCGATAAAAATCCATCTGCTAGCAAAAATGTGCAAAGTCATAGAAAAGCAGAGAAAGAATTGACTTCTGAGCTTAA
TTCCTGGGATTCGAAACAAAAAAAAATGAGAGAAAAGTCAAAAGGGAAAGAATTTACCAATGTAGCAGAATCCTTGATAAGCCAAATCAA
TAAAAGATACAAAACAAAAGATGACATCAAGTCTACAAGAAAATTAAAGGAGTCTTTGATTAACAGTGGTTTTTCAAACAAACCTGTTGT
ACAACTCAGTAAGGAAAAAGTTCAGAAAAAAAGCTACAGAAAACTGAAGACTACCTTTGTTAATGTTACTTCTGAATGCCCAGTGAATGA
TGTTTACAATTTTAATTTGAATGGAGCTGATGACCCTATCATAAAACTTGGAATCCAAGAGTTTCAAGCTACAGCTAAAGAAGCTTGTGC
GGATAGGTCAATTAGATTGGTAGGTCCAAGGAATCATGATGAACTTAAATCTTCTGTCAAAACAAAAGATAAAAAAATTATAACAAATCA
TCAAAAGAAAAATCTGTTTAGTGATACTGAAACAGAGTACAGATGTGATGACAGCAAGACTGATATTAGCTGGCTAAGAGAACCGAAATC
AAAACCACAGCTAATAGACTATAGCAGAAATAAAAATGTGAAGAATCATAAAAGTGGAAAATCAAGATCATCCTTGGAAAAGGGACAGCC
AAGCTCTAAAATGACACCCAGTAAAAATATCACAAAAAAGATGGACAAGACAATTCCGGAAGGAAGAATCAGACTTCCACGAAAAGCAAC
CAAAACAAAAAAAAACTATAAAGATCTCTCAAATTCAGAATCAGAGTGTGAACAAGAATTTTCACATTCATTTAAAGAGAACATACCAGT
AAAGGAGGAGAATATCCATTCCAGAATGAAAACGGTAAAGCTACCAAAGAAACAACAGAAAGTCTTCTGTGCTGAAACAGAAAAGGAACT
ATCAAAACAATGGAAAAACTCATCTCTACTAAAAGATGCTATACGAGATAATTGCCTTGACTTATCTCCCAGATCTTTATCTGGCAGTCC
ATCATCTATAGAAGTAACGAGATGTATAGAGAAAATAACAGAAAAGGATTTTACTCAGGATTATGACTGCATAACAAAATCTATATCACC
TTATCCAAAAACTTCATCACTTGAATCCTTAAATAGTAACAGTGGAGTTGGAGGTACAATAAAGTCACCCAAAAACAATGAGAAAAACTT
CCTGTGTGCAAGTGAAAGTTGTTCACCAATTCCACGACCACTGTTTTTGCCCAGACATACTCCAACTAAGAGTAATACTATTGTAAATAG
AAAAAAAATAAGTTCTCTGGTACTTACACAAGAAACACAAAACAGTAACAGCTATTCAGATGTAAGCAGTTATAGTTCAGAAGAACGGTT
TATGGAAATTGAATCTCCACATATCAATGAAAATTATATACAAAGCAAAAGAGAGGAAAGTCATTTAGCATCTTCATTATCCAAGTCTAG
TGAAGGAAGAGAGAAAACGTGGTTTGACATGCCCTGTGATGCTACTCATGTATCAGGCCCCACCCAACATCTTAGTCGCAAAAGAATATA
TATAGAAGATAATCTAAGTAATTCCAATGAAGTAGAAATGGAAGAGAAAGGAGAAAGGAGAGCAAACTTGCTTCCCAAAAAACTGTGTAA
AATTGAAGATGCAGATCATCATATCCACAAAATGTCTGAAAGTGTATCTTCATTATCAACAAATGACTTTTCTATTCCTTGGGAGACCTG
GCAAAATGAATTTGCAGGGATAGAGATGACTTATGAGACTTACGAGAGGCTCAATTCAGAATTTAAGAGAAGGAATAATATCCGACATAA
AATGTTGAGTTATTTTACTACGCAGTCTTGGAAAACAGCTCAGCAACATCTGAGAACAATGAATCATCAAAGTCAGGACTCTAGGATTAA
AAAACTTGATAAATTCCAATTCATTATCATAGAGGAGCTGGAGAATTTTGAAAAAGATTCACAGTCTTTAAAAGATTTGGAAAAGGAATT
TGTGGACTTTTGGGAAAAGATATTTCAGAAGTTCAGTGCATATCAAAAAAGCGAACAACAGAGGCTTCATCTTTTGAAAACTTCATTGGC
TAAAAGTGTCTTCTGTAATACTGATAGTGAAGAAACTGTTTTTACATCCGAGATGTGTTTGATGAAAGAAGATATGAAAGTGCTGCAAGA
CAGGCTTCTTAAGGACATGCTAGAAGAGGAGCTTCTTAATGTACGCAGAGAACTGATGTCAGTATTCATGTCTCATGAAAGAAATGCTAA
TGTGTGAAATCTAGTTTTTATCACCATACTTTATCTAATTATTATTCTCTGTATATAACTGAGGAAATAAGAATAGTCCTACAAAGAGAA
AAATATACATGTCACCGAAGCAAGTGTACCCTTTATAGGAACCCTCAAATTAAAAAAAAATGTCTTTTAATGGATGAGAGGGAACCACTA
TAACATGAGTCCAAGCCCAGAAGACTTCTGTCTATACAATATTTTTTTTTAATTTTGGAGATAAAAGCTTTAAGAAACTTTTTGAGTTAA
TTATACTCATAAAATGAGTTTCTTTAATAAATTAAATTTTATTGTGTAAAATGTATTATTACATAAAATGTGTTTTTGAATCAATGCAGT
TTGGGGATGAATATAATTAAAATATGTTTAATAACTTAGAATTCAACTAATAAAAATTTAGCCACACTTACAAGGGGGAGGAAGTCCCTA
GTTTAAAATGTATAACTGAGTGGTAGATCAGTACTTTCAGCACACTGTTGGAAACATTTATTCAGATATGGCTCTAATGTATTAGGAAGC
ACTAAATGGCCTAAAAAAGCTACTACATTGCCTAAATATGTTAATTCAATATAGAAGTCCTATTTCATAACCAGGCTGTTTGACAAATAC
TTTTAATCTAGTAGTCATTGTAATATCTTGCTAGATTAATTTATAAAAATGAGTATACATTTGATTTGCTTTTAATGAAGTTGAAATAAA
TGCTTATGTCACTTGAATAAATATAAATCATT

>2512_2512_4_ADNP-SYCP2_ADNP_chr20_49518554_ENST00000396029_SYCP2_chr20_58468648_ENST00000371001_length(amino acids)=1068AA_BP=92
MYYHFEDLDSVSCLALWTTLSIHTETMFQLPVNNLGSLRKARKTVKKILSDIGLEYCKEHIEDFKQFEPNDFYLKNTTWEDVGLWDPSLT
KNQHIKTAKCVENTENKNVEFPNQNFSELQDVIPDSQAAEKRDHTILPGVLDNICGNKIHSKWACWTPVTNIELCNNQRASTSSGDTLNQ
DIVINKKLTKQKSSSSISDHNSEGTGKVKYKKEQTDHIKIDKAEVEVCKKHNQQQNHPKYSGQKNTENAKQSDWPVESETTFKSVLLNKT
IEESLIYRKKYILSKDVNTATCDKNPSASKNVQSHRKAEKELTSELNSWDSKQKKMREKSKGKEFTNVAESLISQINKRYKTKDDIKSTR
KLKESLINSGFSNKPVVQLSKEKVQKKSYRKLKTTFVNVTSECPVNDVYNFNLNGADDPIIKLGIQEFQATAKEACADRSIRLVGPRNHD
ELKSSVKTKDKKIITNHQKKNLFSDTETEYRCDDSKTDISWLREPKSKPQLIDYSRNKNVKNHKSGKSRSSLEKGQPSSKMTPSKNITKK
MDKTIPEGRIRLPRKATKTKKNYKDLSNSESECEQEFSHSFKENIPVKEENIHSRMKTVKLPKKQQKVFCAETEKELSKQWKNSSLLKDA
IRDNCLDLSPRSLSGSPSSIEVTRCIEKITEKDFTQDYDCITKSISPYPKTSSLESLNSNSGVGGTIKSPKNNEKNFLCASESCSPIPRP
LFLPRHTPTKSNTIVNRKKISSLVLTQETQNSNSYSDVSSYSSEERFMEIESPHINENYIQSKREESHLASSLSKSSEGREKTWFDMPCD
ATHVSGPTQHLSRKRIYIEDNLSNSNEVEMEEKGERRANLLPKKLCKIEDADHHIHKMSESVSSLSTNDFSIPWETWQNEFAGIEMTYET
YERLNSEFKRRNNIRHKMLSYFTTQSWKTAQQHLRTMNHQSQDSRIKKLDKFQFIIIEELENFEKDSQSLKDLEKEFVDFWEKIFQKFSA
YQKSEQQRLHLLKTSLAKSVFCNTDSEETVFTSEMCLMKEDMKVLQDRLLKDMLEEELLNVRRELMSVFMSHERNANV

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Fusion Gene PPI Analysis for ADNP-SYCP2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ADNP-SYCP2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ADNP-SYCP2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneADNPC4014538ADNP-related multiple congenital anomalies, intellectual disability, autism spectrum disorder2CTD_human;GENOMICS_ENGLAND;ORPHANET
HgeneADNPC0004352Autistic Disorder1CTD_human
HgeneADNPC0015923Fetal Alcohol Syndrome1PSYGENET
HgeneADNPC0036341Schizophrenia1PSYGENET
HgeneADNPC1535926Neurodevelopmental Disorders1CTD_human
HgeneADNPC1542327Fetus or newborn affected by alcohol transmitted via placenta or breast milk1PSYGENET