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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Diseases

Fusion gene:MACF1-BRAF (FusionGDB2 ID:HG23499TG673)

Fusion Gene Summary for MACF1-BRAF

check button Fusion gene summary
Fusion gene informationFusion gene name: MACF1-BRAF
Fusion gene ID: hg23499tg673
HgeneTgene
Gene symbol

MACF1

BRAF

Gene ID

23499

673

Gene namemicrotubule actin crosslinking factor 1B-Raf proto-oncogene, serine/threonine kinase
SynonymsABP620|ACF7|LIS9|MACF|OFC4B-RAF1|B-raf|BRAF1|NS7|RAFB1
Cytomap('MACF1')('BRAF')

1p34.3

7q34

Type of geneprotein-codingprotein-coding
Descriptionmicrotubule-actin cross-linking factor 1620 kDa actin binding proteinactin cross-linking family protein 7macrophin 1 isoformtrabeculin-alphaserine/threonine-protein kinase B-raf94 kDa B-raf proteinB-Raf proto-oncogene serine/threonine-protein kinase (p94)B-Raf serine/threonine-proteinmurine sarcoma viral (v-raf) oncogene homolog B1proto-oncogene B-Rafv-raf murine sarcoma viral oncogene
Modification date2020031320200329
UniProtAcc.

P15056

Ensembl transtripts involved in fusion geneENST00000289893, ENST00000317713, 
ENST00000361689, ENST00000372915, 
ENST00000539005, ENST00000545844, 
ENST00000564288, ENST00000567887, 
ENST00000476350, ENST00000484793, 
ENST00000536367, ENST00000602421, 
ENST00000476350, ENST00000484793, 
ENST00000536367, ENST00000602421, 
ENST00000289893, ENST00000317713, 
ENST00000361689, ENST00000372915, 
ENST00000539005, ENST00000545844, 
ENST00000564288, ENST00000567887, 
Fusion gene scores* DoF score46 X 37 X 13=2212648 X 58 X 16=44544
# samples 4469
** MAII scorelog2(44/22126*10)=-5.65209532630239
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(69/44544*10)=-6.0124909441832
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MACF1 [Title/Abstract] AND BRAF [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointMACF1(39896580)-BRAF(140487384), # samples:4
Anticipated loss of major functional domain due to fusion event.BRAF-MACF1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
BRAF-MACF1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
MACF1-BRAF seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
MACF1-BRAF seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
MACF1-BRAF seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
MACF1-BRAF seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneMACF1

GO:0030334

regulation of cell migration

27693509

HgeneMACF1

GO:0043001

Golgi to plasma membrane protein transport

15265687

HgeneMACF1

GO:0045773

positive regulation of axon extension

22705394

HgeneMACF1

GO:0051893

regulation of focal adhesion assembly

27693509

TgeneBRAF

GO:0000186

activation of MAPKK activity

29433126

TgeneBRAF

GO:0006468

protein phosphorylation

17563371

TgeneBRAF

GO:0010828

positive regulation of glucose transmembrane transport

23010278

TgeneBRAF

GO:0033138

positive regulation of peptidyl-serine phosphorylation

19667065

TgeneBRAF

GO:0043066

negative regulation of apoptotic process

19667065

TgeneBRAF

GO:0070374

positive regulation of ERK1 and ERK2 cascade

22065586

TgeneBRAF

GO:0071277

cellular response to calcium ion

18567582

TgeneBRAF

GO:0090150

establishment of protein localization to membrane

23010278


check buttonFusion gene breakpoints across MACF1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across BRAF (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4THCATCGA-DE-A0Y2-01AMACF1chr1

39896580

-BRAFchr7

140487384

-
ChimerDB4THCATCGA-DE-A0Y2-01AMACF1chr1

39896580

+BRAFchr7

140487384

-
ChimerDB4THCATCGA-DE-A0Y2MACF1chr1

39896580

+BRAFchr7

140487384

-


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Fusion Gene ORF analysis for MACF1-BRAF

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000289893ENST00000288602MACF1chr1

39896580

+BRAFchr7

140487384

-
In-frameENST00000317713ENST00000288602MACF1chr1

39896580

+BRAFchr7

140487384

-
In-frameENST00000361689ENST00000288602MACF1chr1

39896580

+BRAFchr7

140487384

-
In-frameENST00000372915ENST00000288602MACF1chr1

39896580

+BRAFchr7

140487384

-
In-frameENST00000539005ENST00000288602MACF1chr1

39896580

+BRAFchr7

140487384

-
In-frameENST00000545844ENST00000288602MACF1chr1

39896580

+BRAFchr7

140487384

-
In-frameENST00000564288ENST00000288602MACF1chr1

39896580

+BRAFchr7

140487384

-
In-frameENST00000567887ENST00000288602MACF1chr1

39896580

+BRAFchr7

140487384

-
intron-3CDSENST00000476350ENST00000288602MACF1chr1

39896580

+BRAFchr7

140487384

-
intron-3CDSENST00000484793ENST00000288602MACF1chr1

39896580

+BRAFchr7

140487384

-
intron-3CDSENST00000536367ENST00000288602MACF1chr1

39896580

+BRAFchr7

140487384

-
intron-3CDSENST00000602421ENST00000288602MACF1chr1

39896580

+BRAFchr7

140487384

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000545844MACF1chr139896580+ENST00000288602BRAFchr7140487384-1253811259108124194103
ENST00000567887MACF1chr139896580+ENST00000288602BRAFchr7140487384-188841760534187656243
ENST00000372915MACF1chr139896580+ENST00000288602BRAFchr7140487384-18391171126182726088
ENST00000361689MACF1chr139896580+ENST00000288602BRAFchr7140487384-124821120352123634103
ENST00000539005MACF1chr139896580+ENST00000288602BRAFchr7140487384-120921081352119733973
ENST00000317713MACF1chr139896580+ENST00000288602BRAFchr7140487384-124821120352123634103
ENST00000564288MACF1chr139896580+ENST00000288602BRAFchr7140487384-1939318114771192746167
ENST00000289893MACF1chr139896580+ENST00000288602BRAFchr7140487384-1406712788131139484605

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000545844ENST00000288602MACF1chr139896580+BRAFchr7140487384-0.0047514560.9952486
ENST00000567887ENST00000288602MACF1chr139896580+BRAFchr7140487384-0.0027409720.997259
ENST00000372915ENST00000288602MACF1chr139896580+BRAFchr7140487384-0.0035447560.9964553
ENST00000361689ENST00000288602MACF1chr139896580+BRAFchr7140487384-0.0044889030.9955112
ENST00000539005ENST00000288602MACF1chr139896580+BRAFchr7140487384-0.0061684630.9938315
ENST00000317713ENST00000288602MACF1chr139896580+BRAFchr7140487384-0.0044889030.9955112
ENST00000564288ENST00000288602MACF1chr139896580+BRAFchr7140487384-0.0043972790.9956027
ENST00000289893ENST00000288602MACF1chr139896580+BRAFchr7140487384-0.0026391740.99736077

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Fusion Genomic Features for MACF1-BRAF


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for MACF1-BRAF


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:39896580/chr7:140487384)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.BRAF

P15056

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Protein kinase involved in the transduction of mitogenic signals from the cell membrane to the nucleus (Probable). Phosphorylates MAP2K1, and thereby activates the MAP kinase signal transduction pathway (PubMed:21441910, PubMed:29433126). May play a role in the postsynaptic responses of hippocampal neurons (PubMed:1508179). {ECO:0000269|PubMed:1508179, ECO:0000269|PubMed:21441910, ECO:0000269|PubMed:29433126, ECO:0000305}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMACF1chr1:39896580chr7:140487384ENST00000289893+30641122_112742195939.0Compositional biasNote=Poly-Ser
HgeneMACF1chr1:39896580chr7:140487384ENST00000289893+30641414_141742195939.0Compositional biasNote=Poly-Glu
HgeneMACF1chr1:39896580chr7:140487384ENST00000289893+30641986_198942195939.0Compositional biasNote=Poly-Leu
HgeneMACF1chr1:39896580chr7:140487384ENST00000289893+3064698_70342195939.0Compositional biasNote=Poly-Glu
HgeneMACF1chr1:39896580chr7:140487384ENST00000361689+60931122_112737175431.0Compositional biasNote=Poly-Ser
HgeneMACF1chr1:39896580chr7:140487384ENST00000361689+60931414_141737175431.0Compositional biasNote=Poly-Glu
HgeneMACF1chr1:39896580chr7:140487384ENST00000361689+60931986_198937175431.0Compositional biasNote=Poly-Leu
HgeneMACF1chr1:39896580chr7:140487384ENST00000361689+6093698_70337175431.0Compositional biasNote=Poly-Glu
HgeneMACF1chr1:39896580chr7:140487384ENST00000372915+64971122_112756757389.0Compositional biasNote=Poly-Ser
HgeneMACF1chr1:39896580chr7:140487384ENST00000372915+64971414_141756757389.0Compositional biasNote=Poly-Glu
HgeneMACF1chr1:39896580chr7:140487384ENST00000372915+64971986_198956757389.0Compositional biasNote=Poly-Leu
HgeneMACF1chr1:39896580chr7:140487384ENST00000372915+6497698_70356757389.0Compositional biasNote=Poly-Glu
HgeneMACF1chr1:39896580chr7:140487384ENST00000545844+61941122_112737175431.0Compositional biasNote=Poly-Ser
HgeneMACF1chr1:39896580chr7:140487384ENST00000545844+61941414_141737175431.0Compositional biasNote=Poly-Glu
HgeneMACF1chr1:39896580chr7:140487384ENST00000545844+61941986_198937175431.0Compositional biasNote=Poly-Leu
HgeneMACF1chr1:39896580chr7:140487384ENST00000545844+6194698_70337175431.0Compositional biasNote=Poly-Glu
HgeneMACF1chr1:39896580chr7:140487384ENST00000289893+3064194_29842195939.0DomainCalponin-homology (CH) 2
HgeneMACF1chr1:39896580chr7:140487384ENST00000289893+306478_18142195939.0DomainCalponin-homology (CH) 1
HgeneMACF1chr1:39896580chr7:140487384ENST00000289893+3064868_92542195939.0DomainSH3
HgeneMACF1chr1:39896580chr7:140487384ENST00000361689+6093194_29837175431.0DomainCalponin-homology (CH) 2
HgeneMACF1chr1:39896580chr7:140487384ENST00000361689+609378_18137175431.0DomainCalponin-homology (CH) 1
HgeneMACF1chr1:39896580chr7:140487384ENST00000361689+6093868_92537175431.0DomainSH3
HgeneMACF1chr1:39896580chr7:140487384ENST00000372915+6497194_29856757389.0DomainCalponin-homology (CH) 2
HgeneMACF1chr1:39896580chr7:140487384ENST00000372915+649778_18156757389.0DomainCalponin-homology (CH) 1
HgeneMACF1chr1:39896580chr7:140487384ENST00000372915+6497868_92556757389.0DomainSH3
HgeneMACF1chr1:39896580chr7:140487384ENST00000545844+6194194_29837175431.0DomainCalponin-homology (CH) 2
HgeneMACF1chr1:39896580chr7:140487384ENST00000545844+619478_18137175431.0DomainCalponin-homology (CH) 1
HgeneMACF1chr1:39896580chr7:140487384ENST00000545844+6194868_92537175431.0DomainSH3
HgeneMACF1chr1:39896580chr7:140487384ENST00000289893+30641_29542195939.0RegionNote=Actin-binding
HgeneMACF1chr1:39896580chr7:140487384ENST00000361689+60931_29537175431.0RegionNote=Actin-binding
HgeneMACF1chr1:39896580chr7:140487384ENST00000372915+64971_29556757389.0RegionNote=Actin-binding
HgeneMACF1chr1:39896580chr7:140487384ENST00000545844+61941_29537175431.0RegionNote=Actin-binding
HgeneMACF1chr1:39896580chr7:140487384ENST00000289893+30641050_107342195939.0RepeatNote=LRR 5
HgeneMACF1chr1:39896580chr7:140487384ENST00000289893+30641128_115442195939.0RepeatNote=LRR 6
HgeneMACF1chr1:39896580chr7:140487384ENST00000289893+30641187_121042195939.0RepeatNote=LRR 7
HgeneMACF1chr1:39896580chr7:140487384ENST00000289893+30641257_128242195939.0RepeatNote=LRR 8
HgeneMACF1chr1:39896580chr7:140487384ENST00000289893+3064148_17142195939.0RepeatNote=LRR 1
HgeneMACF1chr1:39896580chr7:140487384ENST00000289893+30641577_162142195939.0RepeatNote=Plectin 1
HgeneMACF1chr1:39896580chr7:140487384ENST00000289893+30641654_169642195939.0RepeatNote=Plectin 2
HgeneMACF1chr1:39896580chr7:140487384ENST00000289893+30641769_180942195939.0RepeatNote=Plectin 3
HgeneMACF1chr1:39896580chr7:140487384ENST00000289893+30641811_184842195939.0RepeatNote=Plectin 4
HgeneMACF1chr1:39896580chr7:140487384ENST00000289893+30641855_188642195939.0RepeatNote=Plectin 5
HgeneMACF1chr1:39896580chr7:140487384ENST00000289893+30642290_233242195939.0RepeatNote=Plectin 6
HgeneMACF1chr1:39896580chr7:140487384ENST00000289893+30642367_241042195939.0RepeatNote=Plectin 7
HgeneMACF1chr1:39896580chr7:140487384ENST00000289893+3064240_26442195939.0RepeatNote=LRR 2
HgeneMACF1chr1:39896580chr7:140487384ENST00000289893+30642411_243742195939.0RepeatNote=Plectin 8
HgeneMACF1chr1:39896580chr7:140487384ENST00000289893+30642501_254342195939.0RepeatNote=Plectin 9
HgeneMACF1chr1:39896580chr7:140487384ENST00000289893+30642581_261242195939.0RepeatNote=Plectin 10
HgeneMACF1chr1:39896580chr7:140487384ENST00000289893+30642686_273042195939.0RepeatNote=Plectin 11
HgeneMACF1chr1:39896580chr7:140487384ENST00000289893+30643239_326242195939.0RepeatNote=LRR 9
HgeneMACF1chr1:39896580chr7:140487384ENST00000289893+30643264_328342195939.0RepeatNote=LRR 10
HgeneMACF1chr1:39896580chr7:140487384ENST00000289893+30643646_366942195939.0RepeatNote=LRR 11
HgeneMACF1chr1:39896580chr7:140487384ENST00000289893+30643696_372042195939.0RepeatNote=LRR 12
HgeneMACF1chr1:39896580chr7:140487384ENST00000289893+3064377_39942195939.0RepeatNote=LRR 3
HgeneMACF1chr1:39896580chr7:140487384ENST00000289893+30643883_395742195939.0RepeatNote=Spectrin 1
HgeneMACF1chr1:39896580chr7:140487384ENST00000289893+30643936_395842195939.0RepeatNote=LRR 13
HgeneMACF1chr1:39896580chr7:140487384ENST00000289893+30644000_410842195939.0RepeatNote=Spectrin 2
HgeneMACF1chr1:39896580chr7:140487384ENST00000289893+30644125_415042195939.0RepeatNote=LRR 14
HgeneMACF1chr1:39896580chr7:140487384ENST00000289893+3064441_46442195939.0RepeatNote=LRR 4
HgeneMACF1chr1:39896580chr7:140487384ENST00000361689+60931050_107337175431.0RepeatNote=LRR 5
HgeneMACF1chr1:39896580chr7:140487384ENST00000361689+60931128_115437175431.0RepeatNote=LRR 6
HgeneMACF1chr1:39896580chr7:140487384ENST00000361689+60931187_121037175431.0RepeatNote=LRR 7
HgeneMACF1chr1:39896580chr7:140487384ENST00000361689+60931257_128237175431.0RepeatNote=LRR 8
HgeneMACF1chr1:39896580chr7:140487384ENST00000361689+6093148_17137175431.0RepeatNote=LRR 1
HgeneMACF1chr1:39896580chr7:140487384ENST00000361689+60931577_162137175431.0RepeatNote=Plectin 1
HgeneMACF1chr1:39896580chr7:140487384ENST00000361689+60931654_169637175431.0RepeatNote=Plectin 2
HgeneMACF1chr1:39896580chr7:140487384ENST00000361689+60931769_180937175431.0RepeatNote=Plectin 3
HgeneMACF1chr1:39896580chr7:140487384ENST00000361689+60931811_184837175431.0RepeatNote=Plectin 4
HgeneMACF1chr1:39896580chr7:140487384ENST00000361689+60931855_188637175431.0RepeatNote=Plectin 5
HgeneMACF1chr1:39896580chr7:140487384ENST00000361689+60932290_233237175431.0RepeatNote=Plectin 6
HgeneMACF1chr1:39896580chr7:140487384ENST00000361689+60932367_241037175431.0RepeatNote=Plectin 7
HgeneMACF1chr1:39896580chr7:140487384ENST00000361689+6093240_26437175431.0RepeatNote=LRR 2
HgeneMACF1chr1:39896580chr7:140487384ENST00000361689+60932411_243737175431.0RepeatNote=Plectin 8
HgeneMACF1chr1:39896580chr7:140487384ENST00000361689+60932501_254337175431.0RepeatNote=Plectin 9
HgeneMACF1chr1:39896580chr7:140487384ENST00000361689+60932581_261237175431.0RepeatNote=Plectin 10
HgeneMACF1chr1:39896580chr7:140487384ENST00000361689+60932686_273037175431.0RepeatNote=Plectin 11
HgeneMACF1chr1:39896580chr7:140487384ENST00000361689+60933239_326237175431.0RepeatNote=LRR 9
HgeneMACF1chr1:39896580chr7:140487384ENST00000361689+60933264_328337175431.0RepeatNote=LRR 10
HgeneMACF1chr1:39896580chr7:140487384ENST00000361689+60933646_366937175431.0RepeatNote=LRR 11
HgeneMACF1chr1:39896580chr7:140487384ENST00000361689+60933696_372037175431.0RepeatNote=LRR 12
HgeneMACF1chr1:39896580chr7:140487384ENST00000361689+6093377_39937175431.0RepeatNote=LRR 3
HgeneMACF1chr1:39896580chr7:140487384ENST00000361689+6093441_46437175431.0RepeatNote=LRR 4
HgeneMACF1chr1:39896580chr7:140487384ENST00000372915+64971050_107356757389.0RepeatNote=LRR 5
HgeneMACF1chr1:39896580chr7:140487384ENST00000372915+64971128_115456757389.0RepeatNote=LRR 6
HgeneMACF1chr1:39896580chr7:140487384ENST00000372915+64971187_121056757389.0RepeatNote=LRR 7
HgeneMACF1chr1:39896580chr7:140487384ENST00000372915+64971257_128256757389.0RepeatNote=LRR 8
HgeneMACF1chr1:39896580chr7:140487384ENST00000372915+6497148_17156757389.0RepeatNote=LRR 1
HgeneMACF1chr1:39896580chr7:140487384ENST00000372915+64971577_162156757389.0RepeatNote=Plectin 1
HgeneMACF1chr1:39896580chr7:140487384ENST00000372915+64971654_169656757389.0RepeatNote=Plectin 2
HgeneMACF1chr1:39896580chr7:140487384ENST00000372915+64971769_180956757389.0RepeatNote=Plectin 3
HgeneMACF1chr1:39896580chr7:140487384ENST00000372915+64971811_184856757389.0RepeatNote=Plectin 4
HgeneMACF1chr1:39896580chr7:140487384ENST00000372915+64971855_188656757389.0RepeatNote=Plectin 5
HgeneMACF1chr1:39896580chr7:140487384ENST00000372915+64972290_233256757389.0RepeatNote=Plectin 6
HgeneMACF1chr1:39896580chr7:140487384ENST00000372915+64972367_241056757389.0RepeatNote=Plectin 7
HgeneMACF1chr1:39896580chr7:140487384ENST00000372915+6497240_26456757389.0RepeatNote=LRR 2
HgeneMACF1chr1:39896580chr7:140487384ENST00000372915+64972411_243756757389.0RepeatNote=Plectin 8
HgeneMACF1chr1:39896580chr7:140487384ENST00000372915+64972501_254356757389.0RepeatNote=Plectin 9
HgeneMACF1chr1:39896580chr7:140487384ENST00000372915+64972581_261256757389.0RepeatNote=Plectin 10
HgeneMACF1chr1:39896580chr7:140487384ENST00000372915+64972686_273056757389.0RepeatNote=Plectin 11
HgeneMACF1chr1:39896580chr7:140487384ENST00000372915+64973239_326256757389.0RepeatNote=LRR 9
HgeneMACF1chr1:39896580chr7:140487384ENST00000372915+64973264_328356757389.0RepeatNote=LRR 10
HgeneMACF1chr1:39896580chr7:140487384ENST00000372915+64973646_366956757389.0RepeatNote=LRR 11
HgeneMACF1chr1:39896580chr7:140487384ENST00000372915+64973696_372056757389.0RepeatNote=LRR 12
HgeneMACF1chr1:39896580chr7:140487384ENST00000372915+6497377_39956757389.0RepeatNote=LRR 3
HgeneMACF1chr1:39896580chr7:140487384ENST00000372915+64973883_395756757389.0RepeatNote=Spectrin 1
HgeneMACF1chr1:39896580chr7:140487384ENST00000372915+64973936_395856757389.0RepeatNote=LRR 13
HgeneMACF1chr1:39896580chr7:140487384ENST00000372915+64974000_410856757389.0RepeatNote=Spectrin 2
HgeneMACF1chr1:39896580chr7:140487384ENST00000372915+64974125_415056757389.0RepeatNote=LRR 14
HgeneMACF1chr1:39896580chr7:140487384ENST00000372915+64974261_428756757389.0RepeatNote=LRR 15
HgeneMACF1chr1:39896580chr7:140487384ENST00000372915+6497441_46456757389.0RepeatNote=LRR 4
HgeneMACF1chr1:39896580chr7:140487384ENST00000372915+64974466_457456757389.0RepeatNote=Spectrin 3
HgeneMACF1chr1:39896580chr7:140487384ENST00000372915+64974511_453456757389.0RepeatNote=LRR 16
HgeneMACF1chr1:39896580chr7:140487384ENST00000372915+64974601_462456757389.0RepeatNote=LRR 17
HgeneMACF1chr1:39896580chr7:140487384ENST00000372915+64974769_479256757389.0RepeatNote=LRR 18
HgeneMACF1chr1:39896580chr7:140487384ENST00000372915+64974800_490456757389.0RepeatNote=Spectrin 4
HgeneMACF1chr1:39896580chr7:140487384ENST00000372915+64974909_501256757389.0RepeatNote=Spectrin 5
HgeneMACF1chr1:39896580chr7:140487384ENST00000372915+64975051_507656757389.0RepeatNote=LRR 19
HgeneMACF1chr1:39896580chr7:140487384ENST00000372915+64975172_519456757389.0RepeatNote=LRR 20
HgeneMACF1chr1:39896580chr7:140487384ENST00000372915+64975236_534156757389.0RepeatNote=Spectrin 6
HgeneMACF1chr1:39896580chr7:140487384ENST00000372915+64975281_530456757389.0RepeatNote=LRR 21
HgeneMACF1chr1:39896580chr7:140487384ENST00000372915+64975348_545056757389.0RepeatNote=Spectrin 7
HgeneMACF1chr1:39896580chr7:140487384ENST00000372915+64975455_555756757389.0RepeatNote=Spectrin 8
HgeneMACF1chr1:39896580chr7:140487384ENST00000545844+61941050_107337175431.0RepeatNote=LRR 5
HgeneMACF1chr1:39896580chr7:140487384ENST00000545844+61941128_115437175431.0RepeatNote=LRR 6
HgeneMACF1chr1:39896580chr7:140487384ENST00000545844+61941187_121037175431.0RepeatNote=LRR 7
HgeneMACF1chr1:39896580chr7:140487384ENST00000545844+61941257_128237175431.0RepeatNote=LRR 8
HgeneMACF1chr1:39896580chr7:140487384ENST00000545844+6194148_17137175431.0RepeatNote=LRR 1
HgeneMACF1chr1:39896580chr7:140487384ENST00000545844+61941577_162137175431.0RepeatNote=Plectin 1
HgeneMACF1chr1:39896580chr7:140487384ENST00000545844+61941654_169637175431.0RepeatNote=Plectin 2
HgeneMACF1chr1:39896580chr7:140487384ENST00000545844+61941769_180937175431.0RepeatNote=Plectin 3
HgeneMACF1chr1:39896580chr7:140487384ENST00000545844+61941811_184837175431.0RepeatNote=Plectin 4
HgeneMACF1chr1:39896580chr7:140487384ENST00000545844+61941855_188637175431.0RepeatNote=Plectin 5
HgeneMACF1chr1:39896580chr7:140487384ENST00000545844+61942290_233237175431.0RepeatNote=Plectin 6
HgeneMACF1chr1:39896580chr7:140487384ENST00000545844+61942367_241037175431.0RepeatNote=Plectin 7
HgeneMACF1chr1:39896580chr7:140487384ENST00000545844+6194240_26437175431.0RepeatNote=LRR 2
HgeneMACF1chr1:39896580chr7:140487384ENST00000545844+61942411_243737175431.0RepeatNote=Plectin 8
HgeneMACF1chr1:39896580chr7:140487384ENST00000545844+61942501_254337175431.0RepeatNote=Plectin 9
HgeneMACF1chr1:39896580chr7:140487384ENST00000545844+61942581_261237175431.0RepeatNote=Plectin 10
HgeneMACF1chr1:39896580chr7:140487384ENST00000545844+61942686_273037175431.0RepeatNote=Plectin 11
HgeneMACF1chr1:39896580chr7:140487384ENST00000545844+61943239_326237175431.0RepeatNote=LRR 9
HgeneMACF1chr1:39896580chr7:140487384ENST00000545844+61943264_328337175431.0RepeatNote=LRR 10
HgeneMACF1chr1:39896580chr7:140487384ENST00000545844+61943646_366937175431.0RepeatNote=LRR 11
HgeneMACF1chr1:39896580chr7:140487384ENST00000545844+61943696_372037175431.0RepeatNote=LRR 12
HgeneMACF1chr1:39896580chr7:140487384ENST00000545844+6194377_39937175431.0RepeatNote=LRR 3
HgeneMACF1chr1:39896580chr7:140487384ENST00000545844+6194441_46437175431.0RepeatNote=LRR 4
TgeneBRAFchr1:39896580chr7:140487384ENST00000288602718428_432380767.0Compositional biasNote=Poly-Ser
TgeneBRAFchr1:39896580chr7:140487384ENST00000288602718457_717380767.0DomainProtein kinase
TgeneBRAFchr1:39896580chr7:140487384ENST00000288602718463_471380767.0Nucleotide bindingATP

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMACF1chr1:39896580chr7:140487384ENST00000289893+30647054_706542195939.0Calcium binding1
HgeneMACF1chr1:39896580chr7:140487384ENST00000289893+30647090_710142195939.0Calcium binding2
HgeneMACF1chr1:39896580chr7:140487384ENST00000361689+60937054_706537175431.0Calcium binding1
HgeneMACF1chr1:39896580chr7:140487384ENST00000361689+60937090_710137175431.0Calcium binding2
HgeneMACF1chr1:39896580chr7:140487384ENST00000372915+64977054_706556757389.0Calcium binding1
HgeneMACF1chr1:39896580chr7:140487384ENST00000372915+64977090_710156757389.0Calcium binding2
HgeneMACF1chr1:39896580chr7:140487384ENST00000545844+61947054_706537175431.0Calcium binding1
HgeneMACF1chr1:39896580chr7:140487384ENST00000545844+61947090_710137175431.0Calcium binding2
HgeneMACF1chr1:39896580chr7:140487384ENST00000289893+30647222_735142195939.0Compositional biasNote=Ser-rich
HgeneMACF1chr1:39896580chr7:140487384ENST00000361689+60937222_735137175431.0Compositional biasNote=Ser-rich
HgeneMACF1chr1:39896580chr7:140487384ENST00000372915+64977222_735156757389.0Compositional biasNote=Ser-rich
HgeneMACF1chr1:39896580chr7:140487384ENST00000545844+61947222_735137175431.0Compositional biasNote=Ser-rich
HgeneMACF1chr1:39896580chr7:140487384ENST00000289893+30647041_707642195939.0DomainEF-hand 1
HgeneMACF1chr1:39896580chr7:140487384ENST00000289893+30647077_711242195939.0DomainEF-hand 2
HgeneMACF1chr1:39896580chr7:140487384ENST00000289893+30647117_718942195939.0DomainGAR
HgeneMACF1chr1:39896580chr7:140487384ENST00000361689+60937041_707637175431.0DomainEF-hand 1
HgeneMACF1chr1:39896580chr7:140487384ENST00000361689+60937077_711237175431.0DomainEF-hand 2
HgeneMACF1chr1:39896580chr7:140487384ENST00000361689+60937117_718937175431.0DomainGAR
HgeneMACF1chr1:39896580chr7:140487384ENST00000372915+64977041_707656757389.0DomainEF-hand 1
HgeneMACF1chr1:39896580chr7:140487384ENST00000372915+64977077_711256757389.0DomainEF-hand 2
HgeneMACF1chr1:39896580chr7:140487384ENST00000372915+64977117_718956757389.0DomainGAR
HgeneMACF1chr1:39896580chr7:140487384ENST00000545844+61947041_707637175431.0DomainEF-hand 1
HgeneMACF1chr1:39896580chr7:140487384ENST00000545844+61947077_711237175431.0DomainEF-hand 2
HgeneMACF1chr1:39896580chr7:140487384ENST00000545844+61947117_718937175431.0DomainGAR
HgeneMACF1chr1:39896580chr7:140487384ENST00000289893+30647117_738842195939.0RegionC-terminal tail
HgeneMACF1chr1:39896580chr7:140487384ENST00000289893+30647313_732842195939.0RegionNote=4 X 4 AA tandem repeats of [GS]-S-R-[AR]
HgeneMACF1chr1:39896580chr7:140487384ENST00000361689+60937117_738837175431.0RegionC-terminal tail
HgeneMACF1chr1:39896580chr7:140487384ENST00000361689+60937313_732837175431.0RegionNote=4 X 4 AA tandem repeats of [GS]-S-R-[AR]
HgeneMACF1chr1:39896580chr7:140487384ENST00000372915+64977117_738856757389.0RegionC-terminal tail
HgeneMACF1chr1:39896580chr7:140487384ENST00000372915+64977313_732856757389.0RegionNote=4 X 4 AA tandem repeats of [GS]-S-R-[AR]
HgeneMACF1chr1:39896580chr7:140487384ENST00000545844+61947117_738837175431.0RegionC-terminal tail
HgeneMACF1chr1:39896580chr7:140487384ENST00000545844+61947313_732837175431.0RegionNote=4 X 4 AA tandem repeats of [GS]-S-R-[AR]
HgeneMACF1chr1:39896580chr7:140487384ENST00000289893+30644261_428742195939.0RepeatNote=LRR 15
HgeneMACF1chr1:39896580chr7:140487384ENST00000289893+30644466_457442195939.0RepeatNote=Spectrin 3
HgeneMACF1chr1:39896580chr7:140487384ENST00000289893+30644511_453442195939.0RepeatNote=LRR 16
HgeneMACF1chr1:39896580chr7:140487384ENST00000289893+30644601_462442195939.0RepeatNote=LRR 17
HgeneMACF1chr1:39896580chr7:140487384ENST00000289893+30644769_479242195939.0RepeatNote=LRR 18
HgeneMACF1chr1:39896580chr7:140487384ENST00000289893+30644800_490442195939.0RepeatNote=Spectrin 4
HgeneMACF1chr1:39896580chr7:140487384ENST00000289893+30644909_501242195939.0RepeatNote=Spectrin 5
HgeneMACF1chr1:39896580chr7:140487384ENST00000289893+30645051_507642195939.0RepeatNote=LRR 19
HgeneMACF1chr1:39896580chr7:140487384ENST00000289893+30645172_519442195939.0RepeatNote=LRR 20
HgeneMACF1chr1:39896580chr7:140487384ENST00000289893+30645236_534142195939.0RepeatNote=Spectrin 6
HgeneMACF1chr1:39896580chr7:140487384ENST00000289893+30645281_530442195939.0RepeatNote=LRR 21
HgeneMACF1chr1:39896580chr7:140487384ENST00000289893+30645348_545042195939.0RepeatNote=Spectrin 7
HgeneMACF1chr1:39896580chr7:140487384ENST00000289893+30645455_555742195939.0RepeatNote=Spectrin 8
HgeneMACF1chr1:39896580chr7:140487384ENST00000289893+30645695_571942195939.0RepeatNote=LRR 22
HgeneMACF1chr1:39896580chr7:140487384ENST00000289893+30645783_588542195939.0RepeatNote=Spectrin 9
HgeneMACF1chr1:39896580chr7:140487384ENST00000289893+30645804_582842195939.0RepeatNote=LRR 23
HgeneMACF1chr1:39896580chr7:140487384ENST00000289893+30646005_611042195939.0RepeatNote=Spectrin 10
HgeneMACF1chr1:39896580chr7:140487384ENST00000289893+30646115_621942195939.0RepeatNote=Spectrin 11
HgeneMACF1chr1:39896580chr7:140487384ENST00000289893+30646225_632842195939.0RepeatNote=Spectrin 12
HgeneMACF1chr1:39896580chr7:140487384ENST00000289893+30646333_643942195939.0RepeatNote=Spectrin 13
HgeneMACF1chr1:39896580chr7:140487384ENST00000289893+30646443_654742195939.0RepeatNote=Spectrin 14
HgeneMACF1chr1:39896580chr7:140487384ENST00000289893+30646496_651942195939.0RepeatNote=LRR 24
HgeneMACF1chr1:39896580chr7:140487384ENST00000289893+30646552_665842195939.0RepeatNote=Spectrin 15
HgeneMACF1chr1:39896580chr7:140487384ENST00000289893+30646665_676642195939.0RepeatNote=Spectrin 16
HgeneMACF1chr1:39896580chr7:140487384ENST00000289893+30646771_687442195939.0RepeatNote=Spectrin 17
HgeneMACF1chr1:39896580chr7:140487384ENST00000361689+60933883_395737175431.0RepeatNote=Spectrin 1
HgeneMACF1chr1:39896580chr7:140487384ENST00000361689+60933936_395837175431.0RepeatNote=LRR 13
HgeneMACF1chr1:39896580chr7:140487384ENST00000361689+60934000_410837175431.0RepeatNote=Spectrin 2
HgeneMACF1chr1:39896580chr7:140487384ENST00000361689+60934125_415037175431.0RepeatNote=LRR 14
HgeneMACF1chr1:39896580chr7:140487384ENST00000361689+60934261_428737175431.0RepeatNote=LRR 15
HgeneMACF1chr1:39896580chr7:140487384ENST00000361689+60934466_457437175431.0RepeatNote=Spectrin 3
HgeneMACF1chr1:39896580chr7:140487384ENST00000361689+60934511_453437175431.0RepeatNote=LRR 16
HgeneMACF1chr1:39896580chr7:140487384ENST00000361689+60934601_462437175431.0RepeatNote=LRR 17
HgeneMACF1chr1:39896580chr7:140487384ENST00000361689+60934769_479237175431.0RepeatNote=LRR 18
HgeneMACF1chr1:39896580chr7:140487384ENST00000361689+60934800_490437175431.0RepeatNote=Spectrin 4
HgeneMACF1chr1:39896580chr7:140487384ENST00000361689+60934909_501237175431.0RepeatNote=Spectrin 5
HgeneMACF1chr1:39896580chr7:140487384ENST00000361689+60935051_507637175431.0RepeatNote=LRR 19
HgeneMACF1chr1:39896580chr7:140487384ENST00000361689+60935172_519437175431.0RepeatNote=LRR 20
HgeneMACF1chr1:39896580chr7:140487384ENST00000361689+60935236_534137175431.0RepeatNote=Spectrin 6
HgeneMACF1chr1:39896580chr7:140487384ENST00000361689+60935281_530437175431.0RepeatNote=LRR 21
HgeneMACF1chr1:39896580chr7:140487384ENST00000361689+60935348_545037175431.0RepeatNote=Spectrin 7
HgeneMACF1chr1:39896580chr7:140487384ENST00000361689+60935455_555737175431.0RepeatNote=Spectrin 8
HgeneMACF1chr1:39896580chr7:140487384ENST00000361689+60935695_571937175431.0RepeatNote=LRR 22
HgeneMACF1chr1:39896580chr7:140487384ENST00000361689+60935783_588537175431.0RepeatNote=Spectrin 9
HgeneMACF1chr1:39896580chr7:140487384ENST00000361689+60935804_582837175431.0RepeatNote=LRR 23
HgeneMACF1chr1:39896580chr7:140487384ENST00000361689+60936005_611037175431.0RepeatNote=Spectrin 10
HgeneMACF1chr1:39896580chr7:140487384ENST00000361689+60936115_621937175431.0RepeatNote=Spectrin 11
HgeneMACF1chr1:39896580chr7:140487384ENST00000361689+60936225_632837175431.0RepeatNote=Spectrin 12
HgeneMACF1chr1:39896580chr7:140487384ENST00000361689+60936333_643937175431.0RepeatNote=Spectrin 13
HgeneMACF1chr1:39896580chr7:140487384ENST00000361689+60936443_654737175431.0RepeatNote=Spectrin 14
HgeneMACF1chr1:39896580chr7:140487384ENST00000361689+60936496_651937175431.0RepeatNote=LRR 24
HgeneMACF1chr1:39896580chr7:140487384ENST00000361689+60936552_665837175431.0RepeatNote=Spectrin 15
HgeneMACF1chr1:39896580chr7:140487384ENST00000361689+60936665_676637175431.0RepeatNote=Spectrin 16
HgeneMACF1chr1:39896580chr7:140487384ENST00000361689+60936771_687437175431.0RepeatNote=Spectrin 17
HgeneMACF1chr1:39896580chr7:140487384ENST00000372915+64975695_571956757389.0RepeatNote=LRR 22
HgeneMACF1chr1:39896580chr7:140487384ENST00000372915+64975783_588556757389.0RepeatNote=Spectrin 9
HgeneMACF1chr1:39896580chr7:140487384ENST00000372915+64975804_582856757389.0RepeatNote=LRR 23
HgeneMACF1chr1:39896580chr7:140487384ENST00000372915+64976005_611056757389.0RepeatNote=Spectrin 10
HgeneMACF1chr1:39896580chr7:140487384ENST00000372915+64976115_621956757389.0RepeatNote=Spectrin 11
HgeneMACF1chr1:39896580chr7:140487384ENST00000372915+64976225_632856757389.0RepeatNote=Spectrin 12
HgeneMACF1chr1:39896580chr7:140487384ENST00000372915+64976333_643956757389.0RepeatNote=Spectrin 13
HgeneMACF1chr1:39896580chr7:140487384ENST00000372915+64976443_654756757389.0RepeatNote=Spectrin 14
HgeneMACF1chr1:39896580chr7:140487384ENST00000372915+64976496_651956757389.0RepeatNote=LRR 24
HgeneMACF1chr1:39896580chr7:140487384ENST00000372915+64976552_665856757389.0RepeatNote=Spectrin 15
HgeneMACF1chr1:39896580chr7:140487384ENST00000372915+64976665_676656757389.0RepeatNote=Spectrin 16
HgeneMACF1chr1:39896580chr7:140487384ENST00000372915+64976771_687456757389.0RepeatNote=Spectrin 17
HgeneMACF1chr1:39896580chr7:140487384ENST00000545844+61943883_395737175431.0RepeatNote=Spectrin 1
HgeneMACF1chr1:39896580chr7:140487384ENST00000545844+61943936_395837175431.0RepeatNote=LRR 13
HgeneMACF1chr1:39896580chr7:140487384ENST00000545844+61944000_410837175431.0RepeatNote=Spectrin 2
HgeneMACF1chr1:39896580chr7:140487384ENST00000545844+61944125_415037175431.0RepeatNote=LRR 14
HgeneMACF1chr1:39896580chr7:140487384ENST00000545844+61944261_428737175431.0RepeatNote=LRR 15
HgeneMACF1chr1:39896580chr7:140487384ENST00000545844+61944466_457437175431.0RepeatNote=Spectrin 3
HgeneMACF1chr1:39896580chr7:140487384ENST00000545844+61944511_453437175431.0RepeatNote=LRR 16
HgeneMACF1chr1:39896580chr7:140487384ENST00000545844+61944601_462437175431.0RepeatNote=LRR 17
HgeneMACF1chr1:39896580chr7:140487384ENST00000545844+61944769_479237175431.0RepeatNote=LRR 18
HgeneMACF1chr1:39896580chr7:140487384ENST00000545844+61944800_490437175431.0RepeatNote=Spectrin 4
HgeneMACF1chr1:39896580chr7:140487384ENST00000545844+61944909_501237175431.0RepeatNote=Spectrin 5
HgeneMACF1chr1:39896580chr7:140487384ENST00000545844+61945051_507637175431.0RepeatNote=LRR 19
HgeneMACF1chr1:39896580chr7:140487384ENST00000545844+61945172_519437175431.0RepeatNote=LRR 20
HgeneMACF1chr1:39896580chr7:140487384ENST00000545844+61945236_534137175431.0RepeatNote=Spectrin 6
HgeneMACF1chr1:39896580chr7:140487384ENST00000545844+61945281_530437175431.0RepeatNote=LRR 21
HgeneMACF1chr1:39896580chr7:140487384ENST00000545844+61945348_545037175431.0RepeatNote=Spectrin 7
HgeneMACF1chr1:39896580chr7:140487384ENST00000545844+61945455_555737175431.0RepeatNote=Spectrin 8
HgeneMACF1chr1:39896580chr7:140487384ENST00000545844+61945695_571937175431.0RepeatNote=LRR 22
HgeneMACF1chr1:39896580chr7:140487384ENST00000545844+61945783_588537175431.0RepeatNote=Spectrin 9
HgeneMACF1chr1:39896580chr7:140487384ENST00000545844+61945804_582837175431.0RepeatNote=LRR 23
HgeneMACF1chr1:39896580chr7:140487384ENST00000545844+61946005_611037175431.0RepeatNote=Spectrin 10
HgeneMACF1chr1:39896580chr7:140487384ENST00000545844+61946115_621937175431.0RepeatNote=Spectrin 11
HgeneMACF1chr1:39896580chr7:140487384ENST00000545844+61946225_632837175431.0RepeatNote=Spectrin 12
HgeneMACF1chr1:39896580chr7:140487384ENST00000545844+61946333_643937175431.0RepeatNote=Spectrin 13
HgeneMACF1chr1:39896580chr7:140487384ENST00000545844+61946443_654737175431.0RepeatNote=Spectrin 14
HgeneMACF1chr1:39896580chr7:140487384ENST00000545844+61946496_651937175431.0RepeatNote=LRR 24
HgeneMACF1chr1:39896580chr7:140487384ENST00000545844+61946552_665837175431.0RepeatNote=Spectrin 15
HgeneMACF1chr1:39896580chr7:140487384ENST00000545844+61946665_676637175431.0RepeatNote=Spectrin 16
HgeneMACF1chr1:39896580chr7:140487384ENST00000545844+61946771_687437175431.0RepeatNote=Spectrin 17
TgeneBRAFchr1:39896580chr7:140487384ENST00000288602718122_129380767.0Compositional biasNote=Poly-Ser
TgeneBRAFchr1:39896580chr7:140487384ENST000002886027186_11380767.0Compositional biasNote=Poly-Gly
TgeneBRAFchr1:39896580chr7:140487384ENST00000288602718155_227380767.0DomainRBD
TgeneBRAFchr1:39896580chr7:140487384ENST00000288602718234_280380767.0Zinc fingerPhorbol-ester/DAG-type


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Fusion Gene Sequence for MACF1-BRAF


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>50588_50588_1_MACF1-BRAF_MACF1_chr1_39896580_ENST00000289893_BRAF_chr7_140487384_ENST00000288602_length(transcript)=14067nt_BP=12788nt
GGCTCTGATTCAGTTTTCTTTTTCTTCTCTTTTCCTTTTTTTTTTTTTTTTTTTTTTTTTTTTAGGAATGCAGAGCAGTTGCTGGGGTGA
TTGACCTAGGCACAGTGGAGATATTTCCCATCTTCAAAGCCATGCAAAAGGGCCTCCTTGACCAAGACACAGGCCTAGTGCTTCTGGAAT
CTCAGGTTATCATGTCTGGCCTCATTGCCCCTGAGACGGGTGAAAACCTCTCTTTGGAGGAGGGCATAGCCAGAAACCTCATTAATCCCC
AGATGTACCAGCAGCTCCGGGAGCTACAGGATGCCCTGGCCTTAATAAGCAGGCTTACTGAGAGCAGAGGCCCTCTTTCTGTGGTGGAAG
CAATTGAAAAGAGAATAATCAGTGAGACAGTTGGACTGAAAATCTTAGAAGCTCACCTGGCAACTGGAGGTTTCAGTCTTTCCCCTAGTG
AGAACTGTATTAACCTGGAAGAGGCTTTTCATCAAGGCCTCATTTCTGCATGGCTTCATTCAGTATTAGAGTCTTATCTTAGAACATCCA
AGAATTTGATAGACCCTAACACAGCTGAGAAAATTGGTTTGCTGGATCTGATGCAGCGATGTATTGTCCACCAGGAATCAGGATTCAAAT
TACTGCCTGTCAAACAATTGGCAGGGGGGATGGTGAGCTTGAAATCAGGCCGGAAGGTTAGCATTTTCCGTGCAGTTCAGGAAGGGCTAA
TAGATAGGCAGGTCACTGTCCGGTTGCTGGAAGCTCAGCTTTTTGCTGGTGGCATAGTAGATCCAAGAACAGGACACAGACTTACAGTGG
AAGAGGCTGTAAGACATAATCTGATTGACCAAGATATGGCCTGTGCTATCCTCATAAGGCAGCTTCAGACAGGAGGCATCATAGACACTG
TCACGGGGCAAAGGCTAACAATAGATGAAGCAGTGAGCAATGATCTAGTAGCTGCTAAGATCGCCCTTGTGATTCTGGAGTCCCTCTGGT
CATTCATGGGGTTGCTGTGGCCTGAATCTGGAGAGATCCTCCCAATTACAGATGCCCTAGAACAAGGTATTGTGTCTACTGAACTAGCAC
ATAAAATCCTTAGTAACCGACAGCATATTAAGGCTCTGTTTCTACCAGCAACCACAGAGATTTTGTCCTGGAAGAAAGCAATAGAAAGTG
GTATCCTGGATAGAGATCTTGCCAATAACTTAAAATCGATTTGTATACCTGATGTGATGCCCCACATGCAACTAGCAGACTCTGCAGAAC
AAAATATTAATCCTGGAGCAGCAGTTCTACCGTGCAGCAAGAGCCACCCTAAGGCCACAGCAAGCCAGAGTGAGAATCTGTTGTTCCAGC
TGATGACTCACAGCTATATTAATGTGCAAAATGGACAGAGGCTGCTTCTGTTAGATAAAGAGCTGATGGAGACACTAACATCCAGAGATG
AGTATCAAACAAGTCCTCCAAAAGTGGTTGAAATTGGGCATCAAAGGCAAAAAACTCCTGAGGGATTGCAAGAATCAGCTAATGTGAAAA
TCTCAGGAACTTTCAGCAGTGGGTGGACTGTGAGGCTGCCTGAGTTCCAGTTTTCTTCTCAGAACAAAGAATATCCCGATCGGGAAGATT
GCACTACAGAAAAAGGCAAAAAGACCACTGTAGAAACAGAAGATTCTTCTGTAGAGAACCCTGAACAGGATCTGTTTGTAGAACAAAAAG
AGAGAAATCCAAACATTGATGCTTTGAAGGTAATAAATAAAGTCAAATTAGAGGTACAAAGGCAGTTGATAGGTACCCAAAGGGAAGACC
AAACAGCAGTGTCTGTCAGAGAAAATGCCAGCAGGGGACACCTCCTGACCATACCTCCTGCTGAGGCGGAAGGTGTGCCGTTGGTGGTTG
ACAAAGATGTTTTTTCTGTTGAAACACCAAAGAAAGAACATCAACCTCTAAGAAACACTTCCTTTACATGTCAGAATGAACAAGCACACA
CTCTTGAGACTGAATATATTCATGATGAAACTGGAGGATCTCACATAAAACCCCAAAGCAAAAAGTTACAAGTTCAGGTAAAGAAAACTC
TAGGTATAAAGTTAGAACTAAAGTCTGAAACTGATGGGAATGTTCATCCTCTGGACAAAAAGGAAATGTTAAAGAAAACATTTCTGGCTA
AGGATGACCATAAAGAAAGTCAAGAAGCACAGAACATCGCAGGTGGTAGTATGATGATGTCAGAAAAGACCGATGAGGAAGATAGTGGCA
GGGAAATTTTTCTGTCATGCAGTCATCCATTAGAATTGCTTGAAGAAGCTACCTTAAATGTATTATCTGCACAGTTACTAGATGGTGGTA
TCTTTCATGAACAAACAGGTCAAAAGCTCTTACTAAATGAAGCAATATCCCGAGGCATTGTGCCAAGTCACACTGCCGTGAAGCTTATGG
AGAAGCTGAACATGTTTCAGGGGTTCTTTGACTCTCAGACTTGTGAGTCTTTGACAACTGAAGAAGTCATTAATGAAGGTCTGATGGATG
AGAAATTATTACATAATGTCCTCATGGCAGACAAAGCTATAAGTGGTGTCTTAGACCCCCGTACCCAGACACTGTGCTCTGTAAAGGATG
CAGTTACAGTTGGACTTCTTGACAAGGAAACAGCCACCAGAATTTTAGAGAGGCAGGTGGTGACTGGTGGAATTATTGATCTGAAACGAG
GCAAAAAAGTTTCAGTAACTTTGGCCTCAACTCTTGGCTTGGTGGACGTTGCTGACCAGCCAGAACTTATAAATCTGGAGAAAGCTTCCA
AAGGTAGAGATGCTGAAAAAACAGTTAGGGAGAGATTAATTAGTTTACAAATGGAAACAACAGGACTTATAGACCCTGATAGTAAAGCAC
CTTTAACAGTTGTGCAGTCCATTGACAGAGGTCTTTTGGAGAGAGAGGAGGCCGTTCGTTTGTTGACTAAGCAAGTGGTAGATGGAGGTA
TCATTCACCATATATCTGGGATGAGACTTTCTGTTGATAATGCCTTCAGACATGGCTTAATTGGTGAAGATTTAGCCGAGAAACTCAAAA
GAGTTGAGAACTTAAACATCCATCAGATTTTTAATCCTGAAACGAAGGAAAATATTTCCCTCCCTAAAGCCATAAAATTAGATCTTATTA
CCTCAGACCTGAAAAGAGAAATCCAGGAGGTTCAGGCCTTTACTGGAAACTTTGTGGATCTCATTTCTGGTCAGAGATTGACCTTGGCAG
AAGCTAAAAAAGAAGGACTGTTAACTAATGAAGCAGTATTGTCTCCAGGAATGATGCATGGCATTGTAGATCCCGAGAACTGCAGAATTG
TCCCCTACTCAGAATTAGTCAAGAAATGTAAGATTGATATTGAATCTGGACAGAGATATCTAGAAGTAATTCCCTTCTCAGACATTAAAG
ATGGGGTGAGCGACAAAGTGCTTACATTGTCTCAAGCAATTCAGCTTGGAAAAGTAGACTTTGCATCTACGCTGAAGGTTCTAGAAGCCC
AGGCAAATACTGGTGGAATCATAGATACTGCTACTGGAAAAAGACTGACATTGGCATCAGCTTTGGAAGAGAAACTGGTGGATGAAAACA
TGGTCAGAATTATTGCATCTCATCAGGTGTTAAATGGAGGAATTGTTGACATATTTAGTGATCAGAGAGTGACTTTAGTAGAAGCTATTG
AGAAAAGACTGATCAGCCCTGAACTGGCAAATATGATCCAAATAGATAGTTCAGAGTTCAGCGATCACAGGGCTCAGATTGAAAAGCAAG
AAGGGATTGAAGTGTGTGCATTACAAAATGAATTTCTAGGAAAGGATATGTTAATTGCTTGTAATCAGACTGCTGAAATGAGTTGTAATA
AAGTAGAAGAGAGTGAGAGATTATTTCAAGTTGAAAATCAGTCTGCACAAGAAAAGGTTAAAGTGAGAGTTTCTGATGGGGAGCAGGCAA
AAAAGAGCAGGGAAATTTCCTTAAAGGAATTTGGGTGCAAGGATCAACGTAAGCCAAGAATGTCTTCAGATGCTAAAGAATTTATCAGTA
TCATAAATCCTCATAATCTTAAAGGTAAATCCTTGGGCCAAGTGTCATTGACACACCCTTACTCTGAATGTGATTTTAAACTTAAAGAAG
TGGCTAGAAATAACATGGGAAATGATACAAATGAAGAGCAGGAAAAAGCAGTGACAAAAATAGAAATTATTTCTCATATGAAGCAGTCTA
CCTCATGTCTAGATTCTGAAGAAATAAGAGAAAATCAAGGGGAAGTGATTTTGGAAGTACAAGAAACATATTGTGAAACGTCAGGCAAAT
TGCCGAGTGAGCAGGTTTTGCAGCAACCAATGAATGCTCGGGTGAAAAGTAAGAGAGAGAAGAGGGAGGTGATTGTAGAAGAAAGTATCA
GAACATGCAAACCAGCATTTCTTTCTGAAGAAAAGTTGTATCAGGAAACTGCCATTAGAGATGAGCATGACTCCCATATAAAGAGCCAAC
CTAGGGAAATGACCTCAAGTGAAAAAGGGAAAGAAGCTGATACAGAAATGGGATTTTCTATTACTTTTAAAATTGAAGAGTCCTCTTCCC
AAGTGGTACCTCAAGGAATTTCTGTAAAACATTTAGATGCTTTAACACTCTTCAGCTCTAAACAGGCCAATGAAGGAAAAGTAAACAATT
TAAGTCTCTGCTTGACTTTAAAACCAGAAGAAAACTTATCTCGAGAAATTGCCTGTGGGGCCCAGAGTGAACCATTCCCTTGTATGACCC
CAAGACCTGAAGGATTGCACTACCAGGAATCAGATGGAAAAGCCCAAGTGACAGGCCCATCCCAAATTTCCAAAACAGACAAGTCTTTCC
AAGGAACCACCAGACAGGAGACCAACTATCAAGATTCCTGGGTTACTTCGAAAACTAAGGAAACCAAACATCAAATTTCCTCATCTAATG
AATGTAAAGAAAAGTCATACCAAGAAGTATCTTTTGACCCAGCAAGAGGTCTTAAATTGGAAGAAATCACAGTTTCTAGACCAGATTCAA
AAGAAGTCAGGTATCTAGAATTCTCAGACAGAAAAGACCTTCATCATCAGGGCAGCAAAAGTGATGATAAACTTTGTGGAACTCTCAAAT
CTGAAATAGCAACACAGGAACTAACTGGAGAGAAATTTCTAGAAATGGCAAACCCTAATGTTGCAGGTCTAGAAGCAGGATCCATTGAGG
ACATAGTGACTCAGAGAGGTTCCAGAGTCTTGGGATCCTTTCTTCCAGAGAAACTGTTCAAAGGAGTGTCTCAAAAAGAGAATACAGGGC
AACAGAATGCCATCATTAGTCCTACTGTTCTAGAGACCAGTGAAGAAAAGACAGTGTCCCTAACAGTATGCTCTGCAGTGAAGACAGAGA
AGACACCACAGGAAAAGCTCAGAGAAAGCCCTGGCAGTGAACAAACTCCCTTCATGACTGCACCTGAAGGAAAGGGAAATGGAGGTGTAA
ACCCAGAGCCCTTCAGAGCAACTCAGAATGTATTTACCCGGCAACTCTGTTTAGAACATGATGAAAAGCTAGTATCCTATCTGTCTCTGT
TACGGAACATTGAAATGAGGACCAAACAGATTCAACCTTTGGAGCTAAACCTGGCAGAACTACAGGATCTGCTGTGTCAGGCCAAGGTAT
TAGAAAGGGAGTTAAAGGATCTGACCACCTTGGTCAGTCAGGAGCTGGAGTGTGTGAATCAGATTATCATCAGCCAGCCTCAAGAAGTTC
CTGCTCAACTGTTGAAGGCTCTAGAGAAAGATGCCAAGAATCTTCAGAAGTCTCTCAGCTCTGTGAGTGACACTTGGAATTCCAGGCTAC
TCCACTTCCAGAATGCTGTGGAAATAGAAAAGACTAAAGTGTTAAATCAGCACACACAGCTAGAAGGCCGACTTCAAGATCTGAGAGCCT
GGGTTGGCAATAAAAATCTTATTCTGAACAGCAAGGGATCTAACAGTGAAATAGATGTTGACAGCCTGAACCTCTGCCTCCAACAGTATG
AGGATTTGAAACAGCCCATGGCTGAAAGGAAAGCTCAGCTGGATGCTCTTGCTTTTGATATTCAGTTCTTTATCTCAGAACATGCCCAGG
ACTTGTCCCCTCAGCAGAATCGACAGATGCTGAGGCTTCTGAATGAACTGCAGAGGTCCTTCCAGGACATTTTGGAACAGACTGCCGCTC
AGGTGGATGCCTTGCAGGGCCATCTTCAACAAATGGAGCAGGAAGCCCTGGTGAAGACCCTGCAGAAACAACAAAATACCTGTCACCAGC
AACTGGAGGATCTTTGCAGTTGGGTAGGACAGGCAGAAAGAGCACTGGCAGGCCACCAAGGCAGAACCACCCAGCAGGATCTCTCTGCTT
TGCAGAAGAACCAAAGTGACTTGAAGGATTTACAGGATGACATTCAGAATCGTGCCACCTCATTTGCCACTGTTGTCAAGGACATTGAGG
GGTTCATGGAAGAGAATCAGACCAAGCTGAGCCCACGTGAGTTGACAGCTCTTCGGGAAAAGCTTCATCAGGCTAAGGAGCAATATGAGG
CGCTCCAGGAAGAGACACGTGTGGCCCAGAAGGAACTGGAGGAAGCAGTGACCTCCGCCTTACAGCAGGAGACTGAAAAGAGTAAAGCAG
CAAAGGAACTGGCAGAGAACAAGAAGAAGATCGATGCTCTCCTGGATTGGGTAACTTCAGTAGGATCATCTGGTGGACAGCTGCTGACCA
ACCTTCCAGGAATGGAGCAGCTCTCGGGAGCTAGCTTGGAGAAAGGAGCCTTGGACACCACTGATGGTTACATGGGGGTGAATCAAGCCC
CAGAGAAACTGGACAAGCAATGTGAGATGATGAAGGCCCGTCACCAAGAATTGCTGTCCCAGCAGCAAAATTTCATTCTGGCCACCCAGT
CAGCTCAGGCCTTCTTGGATCAGCATGGCCACAATCTCACACCTGAGGAGCAACAGATGCTGCAACAGAAGCTGGGAGAGCTAAAGGAAC
AATACTCTACTTCCCTGGCCCAATCAGAGGCAGAACTGAAGCAGGTGCAGACACTTCAGGATGAGTTGCAGAAATTTCTGCAGGATCATA
AAGAGTTTGAAAGCTGGTTGGAACGATCCGAGAAAGAGCTGGAGAACATGCATAAGGGAGGCAGCAGCCCCGAGACCCTTCCCTCCCTGC
TAAAGCGGCAAGGAAGCTTCTCAGAGGATGTCATTTCCCACAAAGGAGACTTGAGATTTGTGACTATCTCAGGACAGAAAGTCTTGGACA
TGGAAAACAGTTTTAAGGAAGGCAAAGAACCATCAGAAATTGGAAACTTAGTAAAGGACAAGTTGAAGGATGCAACAGAAAGATACACTG
CTCTCCACTCAAAGTGTACACGATTAGGATCTCACCTGAATATGCTGTTAGGCCAGTATCATCAATTCCAAAACAGTGCTGACAGCCTGC
AGGCCTGGATGCAGGCTTGTGAGGCCAACGTGGAGAAGCTCCTCTCAGATACTGTTGCCTCTGACCCTGGAGTTCTCCAGGAGCAGCTTG
CAACAACAAAGCAGTTGCAGGAGGAATTGGCTGAGCACCAAGTACCTGTGGAAAAACTCCAAAAAGTAGCTCGTGACATAATGGAAATTG
AAGGGGAGCCAGCCCCAGACCACAGGCATGTTCAAGAAACTACAGATTCCATACTCAGCCACTTCCAAAGCCTCTCCTATAGCCTGGCTG
AGCGATCTTCTCTGCTGCAGAAAGCAATTGCCCAATCTCAGAGTGTCCAGGAAAGCCTGGAGAGCCTGTTGCAGTCTATTGGGGAAGTTG
AACAAAACCTGGAAGGGAAGCAGGTGTCATCACTCTCATCAGGAGTCATCCAGGAAGCCTTAGCCACAAATATGAAATTGAAGCAGGACA
TTGCTCGGCAAAAGAGCAGCTTGGAGGCCACCCGTGAGATGGTGACCCGATTCATGGAGACAGCAGACAGTACTACAGCAGCAGTGCTGC
AGGGCAAACTGGCAGAGGTGAGCCAGCGGTTCGAACAGCTCTGTCTACAGCAGCAAGAAAAGGAGAGCTCCCTAAAGAAGCTTCTACCCC
AGGCAGAGATGTTTGAACACCTCTCTGGTAAGCTGCAGCAGTTCATGGAAAACAAAAGTCGGATGCTGGCCTCTGGAAATCAGCCAGATC
AAGATATTACACATTTCTTCCAACAGATCCAGGAGCTCAATTTGGAAATGGAAGACCAACAGGAGAACCTAGATACTCTTGAGCACCTGG
TCACTGAACTGAGCTCTTGTGGCTTTGCGCTGGACTTGTGCCAGCATCAGGACAGGGTACAGAATCTAAGAAAAGACTTCACAGAGCTAC
AGAAGACAGTTAAAGAGAGAGAGAAAGATGCATCATCTTGCCAGGAACAGTTGGATGAATTCCGGAAGCTGGTCAGGACCTTCCAGAAAT
GGTTGAAAGAAACTGAAGGGAGTATTCCACCTACGGAAACTTCTATGAGTGCTAAAGAGTTAGAAAAGCAGATTGAACACCTGAAGAGTC
TACTAGATGACTGGGCAAGTAAGGGAACTCTGGTGGAAGAAATCAATTGCAAAGGTACTTCTTTAGAAAATCTCATCATGGAAATCACAG
CACCTGATTCCCAAGGCAAGACAGGTTCCATACTGCCCTCTGTAGGAAGCTCTGTAGGCAGTGTAAACGGATACCACACCTGCAAAGATC
TGACGGAGATCCAGTGTGACATGTCAGATGTAAACTTGAAGTATGAGAAACTAGGGGGAGTACTTCATGAACGCCAGGAAAGCCTTCAGG
CTATCCTCAACAGAATGGAGGAGGTTCACAAGGAGGCAAACTCTGTGCTGCAGTGGCTGGAATCAAAAGAGGAAGTCCTGAAATCCATGG
ATGCCATGTCATCTCCAACCAAGACAGAAACAGTGAAAGCCCAAGCTGAATCTAACAAGGCCTTCCTGGCTGAGTTGGAACAGAATTCTC
CAAAAATTCAAAAAGTAAAGGAAGCCCTGGCTGGATTACTGGTGACATATCCCAACTCACAGGAAGCAGAAAATTGGAAGAAAATTCAGG
AAGAACTCAATTCCCGATGGGAAAGGGCCACTGAGGTTACTGTGGCTCGGCAAAGGCAGCTAGAGGAATCTGCAAGTCATCTGGCCTGCT
TCCAGGCTGCAGAATCCCAGCTCCGGCCGTGGCTGATGGAGAAAGAACTGATGATGGGAGTGCTGGGGCCCCTGTCTATTGACCCCAACA
TGTTGAATGCACAAAAGCAACAGGTCCAGTTTATGCTAAAGGAATTTGAAGCACGCAGGCAACAGCATGAGCAACTGAATGAGGCAGCTC
AGGGCATCCTAACAGGCCCTGGAGATGTCTCTCTGTCCACCAGCCAAGTACAGAAAGAACTCCAGAGCATCAATCAGAAATGGGTTGAGC
TGACTGACAAACTCAACTCCCGTTCCAGCCAAATTGACCAAGCTATTGTTAAGAGCACCCAGTACCAGGAACTGCTCCAGGACTTATCAG
AGAAGGTGAGGGCAGTTGGACAACGGCTGAGTGTCCAGTCAGCTATCAGCACCCAACCAGAGGCTGTAAAGCAGCAATTGGAAGAGACCA
GTGAAATTCGATCTGACTTGGAGCAGTTAGACCACGAGGTTAAGGAGGCTCAGACACTGTGCGATGAACTCTCAGTGCTCATTGGTGAGC
AGTACCTCAAGGATGAACTGAAGAAGCGTTTGGAGACAGTTGCCCTGCCTCTCCAAGGTTTAGAAGACCTTGCAGCCGATCGCATTAACA
GACTCCAGGCAGCTCTTGCCAGCACCCAGCAGTTCCAGCAAATGTTTGATGAGTTGAGGACCTGGTTGGATGATAAACAAAGCCAGCAAG
CAAAAAACTGCCCAATTTCTGCAAAATTGGAGCGGCTACAGTCTCAGCTACAGGAGAATGAAGAGTTTCAGAAAAGTCTTAATCAACACA
GTGGCTCCTATGAGGTGATTGTGGCTGAAGGGGAATCTCTACTTCTTTCTGTACCTCCTGGAGAAGAGAAAAGGACTCTACAAAACCAGT
TGGTTGAGCTCAAAAACCATTGGGAAGAGCTTAGTAAAAAAACTGCAGACAGACAATCCAGGCTCAAGGATTGTATGCAGAAAGCTCAGA
AATATCAGTGGCATGTGGAAGACCTTGTGCCATGGATAGAAGATTGTAAAGCTAAGATGTCTGAGTTGCGAGTCACTCTGGATCCAGTGC
AGCTAGAGTCCAGTCTCCTAAGATCAAAGGCTATGCTGAATGAGGTGGAGAAGCGCCGCTCCCTGCTGGAAATATTGAATAGTGCTGCTG
ACATTCTGATCAATTCTTCAGAAGCAGATGAGGATGGAATCCGGGATGAGAAGGCTGGGATCAACCAGAACATGGATGCTGTTACAGAAG
AGCTGCAGGCCAAAACAGGGTCACTCGAAGAAATGACTCAGAGGCTCAGGGAGTTCCAGGAAAGCTTTAAGAATATTGAAAAGAAGGTTG
AAGGAGCCAAACACCAACTTGAGATCTTTGATGCTCTGGGTTCTCAAGCCTGTAGCAACAAGAACCTGGAGAAGCTAAGAGCTCAACAGG
AAGTGCTGCAGGCCCTAGAGCCTCAGGTAGACTATCTGAGGAACTTTACTCAGGGTCTGGTAGAAGATGCCCCAGATGGATCTGATGCTT
CTCAACTTCTCCACCAAGCTGAGGTCGCCCAGCAAGAGTTCCTCGAAGTTAAGCAAAGAGTGAACAGTGGTTGTGTGATGATGGAAAACA
AGCTGGAGGGGATTGGCCAGTTTCACTGCCGGGTCCGAGAGATGTTCTCTCAATTGGCAGACCTGGATGATGAGCTAGATGGCATGGGTG
CTATTGGCAGAGACACTGATAGCCTCCAGTCCCAAATCGAGGATGTCCGGCTATTCCTTAACAAAATTCACGTCCTCAAATTAGACATAG
AGGCCTCTGAAGCAGAGTGTCGACATATGCTAGAAGAAGAGGGGACTCTGGATTTGTTAGGTCTCAAAAGGGAGCTAGAAGCCCTGAACA
AACAGTGTGGCAAACTGACAGAGAGGGGGAAAGCTCGTCAGGAACAGCTGGAACTGACACTAGGCCGTGTAGAGGACTTCTACAGGAAAT
TGAAAGGACTCAATGACGCGACCACAGCAGCAGAGGAGGCAGAGGCCCTCCAGTGGGTAGTGGGGACCGAAGTGGAAATCATCAACCAAC
AATTAGCAGATTTTAAAATGTTTCAGAAAGAACAAGTGGATCCTCTTCAGATGAAATTGCAGCAGGTGAATGGACTTGGCCAGGGATTAA
TTCAGAGTGCAGGAAAAGACTGTGATGTACAGGGTTTAGAACATGACATGGAAGAGATCAATGCTCGATGGAATACATTGAATAAAAAGG
TCGCACAAAGAATTGCACAGCTACAGGAAGCTTTGTTGCATTGTGGGAAGTTTCAAGATGCCTTGGAGCCATTGCTCAGCTGGTTGGCAG
ATACCGAGGAGCTCATAGCCAATCAGAAACCTCCATCTGCTGAGTATAAAGTGGTGAAAGCACAGATCCAAGAACAGAAGTTGCTCCAGC
GGCTCCTAGATGATCGAAAGGCCACAGTAGACATGCTTCAAGCAGAAGGAGGCAGAATAGCCCAGTCAGCAGAGCTGGCTGATAGAGAGA
AAATCACTGGACAGCTGGAGAGTCTTGAAAGTAGATGGACTGAACTACTCAGTAAGGCAGCAGCCAGGCAAAAACAGCTGGAAGACATCC
TGGTTCTGGCCAAACAGTTCCATGAGACAGCTGAGCCTATTTCTGACTTCTTATCTGTCACAGAGAAAAAGCTTGCTAACTCAGAACCTG
TTGGCACTCAGACTGCCAAAATACAGCAGCAGATCATTCGGCACAAGGCTCTGGAAGAAGACATAGAAAACCATGCAACAGATGTGCACC
AGGCAGTCAAAATTGGGCAGTCCCTCTCCTCCCTGACATCTCCTGCAGAACAGGGTGTGCTGTCAGAAAAGATAGACTCATTGCAGGCCC
GATACAGTGAAATTCAAGACCGCTGTTGTCGGAAGGCAGCCCTACTTGACCAAGCTCTGTCTAATGCTAGGCTGTTTGGGGAGGATGAGG
TGGAGGTGCTCAACTGGCTGGCTGAGGTTGAGGACAAGCTCAGTTCAGTGTTCGTAAAGGATTTCAAACAGGATGTCCTGCACAGGCAGC
ATGCTGACCACCTGGCTTTAAATGAAGAAATTGTTAATAGAAAGAAGAATGTAGATCAAGCTATTAAAAATGGTCAGGCTCTTCTAAAAC
AAACCACAGGTGAGGAGGTGTTACTTATCCAGGAAAAACTAGATGGTATAAAGACTCGTTACGCAGACATCACAGTTACTAGCTCCAAGG
CCCTCAGAACTTTAGAGCAAGCCCGGCAGCTGGCCACCAAGTTCCAGTCTACTTATGAGGAACTGACCGGGTGGCTGAGGGAGGTGGAGG
AGGAGCTGGCAACCAGTGGAGGACAGTCTCCCACAGGGGAACAGATACCCCAGTTTCAGCAGAGACAGAAGGAATTAAAGAAGGAGGTCA
TGGAGCACAGGCTGGTGTTGGACACAGTGAATGAGGTGAGCCGTGCTCTCTTAGAGCTGGTGCCCTGGAGAGCCAGAGAAGGGCTGGATA
AACTTGTGTCCGATGCTAACGAGCAGTACAAACTAGTCAGTGACACTATTGGACAAAGGGTGGATGAAATTGATGCTGCTATTCAGAGAT
CACAACAGGACTTGATTAGAGACCAAGGATTTCGTGGTGATGGAGGATCAACCACAGGTTTGTCTGCTACCCCCCCTGCCTCATTACCTG
GCTCACTAACTAACGTGAAAGCCTTACAGAAATCTCCAGGACCTCAGCGAGAAAGGAAGTCATCTTCATCCTCAGAAGACAGGAATCGAA
TGAAAACACTTGGTAGACGGGACTCGAGTGATGATTGGGAGATTCCTGATGGGCAGATTACAGTGGGACAAAGAATTGGATCTGGATCAT
TTGGAACAGTCTACAAGGGAAAGTGGCATGGTGATGTGGCAGTGAAAATGTTGAATGTGACAGCACCTACACCTCAGCAGTTACAAGCCT
TCAAAAATGAAGTAGGAGTACTCAGGAAAACACGACATGTGAATATCCTACTCTTCATGGGCTATTCCACAAAGCCACAACTGGCTATTG
TTACCCAGTGGTGTGAGGGCTCCAGCTTGTATCACCATCTCCATATCATTGAGACCAAATTTGAGATGATCAAACTTATAGATATTGCAC
GACAGACTGCACAGGGCATGGATTACTTACACGCCAAGTCAATCATCCACAGAGACCTCAAGAGTAATAATATATTTCTTCATGAAGACC
TCACAGTAAAAATAGGTGATTTTGGTCTAGCTACAGTGAAATCTCGATGGAGTGGGTCCCATCAGTTTGAACAGTTGTCTGGATCCATTT
TGTGGATGGCACCAGAAGTCATCAGAATGCAAGATAAAAATCCATACAGCTTTCAGTCAGATGTATATGCATTTGGAATTGTTCTGTATG
AATTGATGACTGGACAGTTACCTTATTCAAACATCAACAACAGGGACCAGATAATTTTTATGGTGGGACGAGGATACCTGTCTCCAGATC
TCAGTAAGGTACGGAGTAACTGTCCAAAAGCCATGAAGAGATTAATGGCAGAGTGCCTCAAAAAGAAAAGAGATGAGAGACCACTCTTTC
CCCAAATTCTCGCCTCTATTGAGCTGCTGGCCCGCTCATTGCCAAAAATTCACCGCAGTGCATCAGAACCCTCCTTGAATCGGGCTGGTT
TCCAAACAGAGGATTTTAGTCTATATGCTTGTGCTTCTCCAAAAACACCCATCCAGGCAGGGGGATATGGTGCGTTTCCTGTCCACTGAA
ACAAATGAGTGAGAGAGTTCAGGAGAGTAGCAACAAAAGGAAAATAAATGAACATATGTTTGCTTATATGTTAAATTGAATAAAATACTC

>50588_50588_1_MACF1-BRAF_MACF1_chr1_39896580_ENST00000289893_BRAF_chr7_140487384_ENST00000288602_length(amino acids)=4605AA_BP=4219
MQKGLLDQDTGLVLLESQVIMSGLIAPETGENLSLEEGIARNLINPQMYQQLRELQDALALISRLTESRGPLSVVEAIEKRIISETVGLK
ILEAHLATGGFSLSPSENCINLEEAFHQGLISAWLHSVLESYLRTSKNLIDPNTAEKIGLLDLMQRCIVHQESGFKLLPVKQLAGGMVSL
KSGRKVSIFRAVQEGLIDRQVTVRLLEAQLFAGGIVDPRTGHRLTVEEAVRHNLIDQDMACAILIRQLQTGGIIDTVTGQRLTIDEAVSN
DLVAAKIALVILESLWSFMGLLWPESGEILPITDALEQGIVSTELAHKILSNRQHIKALFLPATTEILSWKKAIESGILDRDLANNLKSI
CIPDVMPHMQLADSAEQNINPGAAVLPCSKSHPKATASQSENLLFQLMTHSYINVQNGQRLLLLDKELMETLTSRDEYQTSPPKVVEIGH
QRQKTPEGLQESANVKISGTFSSGWTVRLPEFQFSSQNKEYPDREDCTTEKGKKTTVETEDSSVENPEQDLFVEQKERNPNIDALKVINK
VKLEVQRQLIGTQREDQTAVSVRENASRGHLLTIPPAEAEGVPLVVDKDVFSVETPKKEHQPLRNTSFTCQNEQAHTLETEYIHDETGGS
HIKPQSKKLQVQVKKTLGIKLELKSETDGNVHPLDKKEMLKKTFLAKDDHKESQEAQNIAGGSMMMSEKTDEEDSGREIFLSCSHPLELL
EEATLNVLSAQLLDGGIFHEQTGQKLLLNEAISRGIVPSHTAVKLMEKLNMFQGFFDSQTCESLTTEEVINEGLMDEKLLHNVLMADKAI
SGVLDPRTQTLCSVKDAVTVGLLDKETATRILERQVVTGGIIDLKRGKKVSVTLASTLGLVDVADQPELINLEKASKGRDAEKTVRERLI
SLQMETTGLIDPDSKAPLTVVQSIDRGLLEREEAVRLLTKQVVDGGIIHHISGMRLSVDNAFRHGLIGEDLAEKLKRVENLNIHQIFNPE
TKENISLPKAIKLDLITSDLKREIQEVQAFTGNFVDLISGQRLTLAEAKKEGLLTNEAVLSPGMMHGIVDPENCRIVPYSELVKKCKIDI
ESGQRYLEVIPFSDIKDGVSDKVLTLSQAIQLGKVDFASTLKVLEAQANTGGIIDTATGKRLTLASALEEKLVDENMVRIIASHQVLNGG
IVDIFSDQRVTLVEAIEKRLISPELANMIQIDSSEFSDHRAQIEKQEGIEVCALQNEFLGKDMLIACNQTAEMSCNKVEESERLFQVENQ
SAQEKVKVRVSDGEQAKKSREISLKEFGCKDQRKPRMSSDAKEFISIINPHNLKGKSLGQVSLTHPYSECDFKLKEVARNNMGNDTNEEQ
EKAVTKIEIISHMKQSTSCLDSEEIRENQGEVILEVQETYCETSGKLPSEQVLQQPMNARVKSKREKREVIVEESIRTCKPAFLSEEKLY
QETAIRDEHDSHIKSQPREMTSSEKGKEADTEMGFSITFKIEESSSQVVPQGISVKHLDALTLFSSKQANEGKVNNLSLCLTLKPEENLS
REIACGAQSEPFPCMTPRPEGLHYQESDGKAQVTGPSQISKTDKSFQGTTRQETNYQDSWVTSKTKETKHQISSSNECKEKSYQEVSFDP
ARGLKLEEITVSRPDSKEVRYLEFSDRKDLHHQGSKSDDKLCGTLKSEIATQELTGEKFLEMANPNVAGLEAGSIEDIVTQRGSRVLGSF
LPEKLFKGVSQKENTGQQNAIISPTVLETSEEKTVSLTVCSAVKTEKTPQEKLRESPGSEQTPFMTAPEGKGNGGVNPEPFRATQNVFTR
QLCLEHDEKLVSYLSLLRNIEMRTKQIQPLELNLAELQDLLCQAKVLERELKDLTTLVSQELECVNQIIISQPQEVPAQLLKALEKDAKN
LQKSLSSVSDTWNSRLLHFQNAVEIEKTKVLNQHTQLEGRLQDLRAWVGNKNLILNSKGSNSEIDVDSLNLCLQQYEDLKQPMAERKAQL
DALAFDIQFFISEHAQDLSPQQNRQMLRLLNELQRSFQDILEQTAAQVDALQGHLQQMEQEALVKTLQKQQNTCHQQLEDLCSWVGQAER
ALAGHQGRTTQQDLSALQKNQSDLKDLQDDIQNRATSFATVVKDIEGFMEENQTKLSPRELTALREKLHQAKEQYEALQEETRVAQKELE
EAVTSALQQETEKSKAAKELAENKKKIDALLDWVTSVGSSGGQLLTNLPGMEQLSGASLEKGALDTTDGYMGVNQAPEKLDKQCEMMKAR
HQELLSQQQNFILATQSAQAFLDQHGHNLTPEEQQMLQQKLGELKEQYSTSLAQSEAELKQVQTLQDELQKFLQDHKEFESWLERSEKEL
ENMHKGGSSPETLPSLLKRQGSFSEDVISHKGDLRFVTISGQKVLDMENSFKEGKEPSEIGNLVKDKLKDATERYTALHSKCTRLGSHLN
MLLGQYHQFQNSADSLQAWMQACEANVEKLLSDTVASDPGVLQEQLATTKQLQEELAEHQVPVEKLQKVARDIMEIEGEPAPDHRHVQET
TDSILSHFQSLSYSLAERSSLLQKAIAQSQSVQESLESLLQSIGEVEQNLEGKQVSSLSSGVIQEALATNMKLKQDIARQKSSLEATREM
VTRFMETADSTTAAVLQGKLAEVSQRFEQLCLQQQEKESSLKKLLPQAEMFEHLSGKLQQFMENKSRMLASGNQPDQDITHFFQQIQELN
LEMEDQQENLDTLEHLVTELSSCGFALDLCQHQDRVQNLRKDFTELQKTVKEREKDASSCQEQLDEFRKLVRTFQKWLKETEGSIPPTET
SMSAKELEKQIEHLKSLLDDWASKGTLVEEINCKGTSLENLIMEITAPDSQGKTGSILPSVGSSVGSVNGYHTCKDLTEIQCDMSDVNLK
YEKLGGVLHERQESLQAILNRMEEVHKEANSVLQWLESKEEVLKSMDAMSSPTKTETVKAQAESNKAFLAELEQNSPKIQKVKEALAGLL
VTYPNSQEAENWKKIQEELNSRWERATEVTVARQRQLEESASHLACFQAAESQLRPWLMEKELMMGVLGPLSIDPNMLNAQKQQVQFMLK
EFEARRQQHEQLNEAAQGILTGPGDVSLSTSQVQKELQSINQKWVELTDKLNSRSSQIDQAIVKSTQYQELLQDLSEKVRAVGQRLSVQS
AISTQPEAVKQQLEETSEIRSDLEQLDHEVKEAQTLCDELSVLIGEQYLKDELKKRLETVALPLQGLEDLAADRINRLQAALASTQQFQQ
MFDELRTWLDDKQSQQAKNCPISAKLERLQSQLQENEEFQKSLNQHSGSYEVIVAEGESLLLSVPPGEEKRTLQNQLVELKNHWEELSKK
TADRQSRLKDCMQKAQKYQWHVEDLVPWIEDCKAKMSELRVTLDPVQLESSLLRSKAMLNEVEKRRSLLEILNSAADILINSSEADEDGI
RDEKAGINQNMDAVTEELQAKTGSLEEMTQRLREFQESFKNIEKKVEGAKHQLEIFDALGSQACSNKNLEKLRAQQEVLQALEPQVDYLR
NFTQGLVEDAPDGSDASQLLHQAEVAQQEFLEVKQRVNSGCVMMENKLEGIGQFHCRVREMFSQLADLDDELDGMGAIGRDTDSLQSQIE
DVRLFLNKIHVLKLDIEASEAECRHMLEEEGTLDLLGLKRELEALNKQCGKLTERGKARQEQLELTLGRVEDFYRKLKGLNDATTAAEEA
EALQWVVGTEVEIINQQLADFKMFQKEQVDPLQMKLQQVNGLGQGLIQSAGKDCDVQGLEHDMEEINARWNTLNKKVAQRIAQLQEALLH
CGKFQDALEPLLSWLADTEELIANQKPPSAEYKVVKAQIQEQKLLQRLLDDRKATVDMLQAEGGRIAQSAELADREKITGQLESLESRWT
ELLSKAAARQKQLEDILVLAKQFHETAEPISDFLSVTEKKLANSEPVGTQTAKIQQQIIRHKALEEDIENHATDVHQAVKIGQSLSSLTS
PAEQGVLSEKIDSLQARYSEIQDRCCRKAALLDQALSNARLFGEDEVEVLNWLAEVEDKLSSVFVKDFKQDVLHRQHADHLALNEEIVNR
KKNVDQAIKNGQALLKQTTGEEVLLIQEKLDGIKTRYADITVTSSKALRTLEQARQLATKFQSTYEELTGWLREVEEELATSGGQSPTGE
QIPQFQQRQKELKKEVMEHRLVLDTVNEVSRALLELVPWRAREGLDKLVSDANEQYKLVSDTIGQRVDEIDAAIQRSQQDLIRDQGFRGD
GGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVA
VKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKS
IIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINN
RDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASP

--------------------------------------------------------------
>50588_50588_2_MACF1-BRAF_MACF1_chr1_39896580_ENST00000317713_BRAF_chr7_140487384_ENST00000288602_length(transcript)=12482nt_BP=11203nt
ATCACTTCTCCCTGGGCTCCCAGGCCCTCCTGCAGCAGCCCCCGCCTGGGCCATGTCTTCCTCAGATGAAGAGACGCTCAGTGAGCGGTC
ATGTCGGAGTGAGCGGTCTTGTCGGAGTGAGCGATCTTACAGGAGCGAGCGGTCGGGGAGCCTGTCTCCCTGTCCCCCAGGGGACACCTT
GCCCTGGAACCTGCCACTGCATGAGCAGAAAAAGCGGAAAAGCCAGGATTCGGTGCTGGACCCTGCAGAGCGTGCTGTGGTCAGAGTCGC
TGATGAACGGGACCGGGTTCAGAAGAAAACGTTCACCAAGTGGGTCAACAAGCACTTAATGAAGGTCCGCAAGCACATCAATGATCTTTA
TGAAGATCTGCGGGATGGCCATAACCTGATCTCTCTGTTGGAGGTCCTCTCAGGCATCAAACTGCCCCGGGAGAAGGGCAGGATGCGTTT
TCATAGGCTGCAGAATGTGCAGATTGCCCTGGACTTCCTAAAGCAGCGACAGGTGAAACTAGTGAATATTCGCAATGATGACATCACAGA
TGGCAACCCCAAGTTGACCCTGGGTCTGATCTGGACCATTATTTTGCATTTCCAGATCTCTGACATCTACATTAGTGGAGAATCAGGGGA
TATGTCAGCCAAGGAGAAACTACTCCTGTGGACCCAGAAGGTGACAGCTGGTTACACAGGAATCAAATGCACCAACTTTTCCTCCTGCTG
GAGTGATGGGAAGATGTTCAATGCACTCATTCACCGATACCGACCCGATCTAGTAGACATGGAGAGGGTGCAAATCCAAAGTAACCGAGA
GAATCTGGAACAGGCTTTTGAAGTGGCAGAAAGACTGGGGGTCACTCGCCTGCTGGATGCAGAAGATGTGGATGTGCCATCTCCAGATGA
AAAGTCTGTAATCACTTATGTGTCTTCGATTTATGATGCCTTCCCTAAAGTTCCTGAGGGTGGAGAAGGGATCAGTGCTACGGAAGTGGA
CTCCAGGTGGCAAGAATACCAAAGCCGAGTGGACTCCCTCATTCCCTGGATCAAACAGCATACAATACTGATGTCAGATAAAACTTTTCC
CCAAAACCCTGTTGAACTAAAGGCACTTTATAACCAATATATACACTTCAAAGAAACAGAAATTCTGGCCAAGGAGAGAGAAAAAGGAAG
AATTGAGGAATTATATAAATTACTAGAGGTGTGGATTGAATTTGGCCGAATTAAACTGCCTCAAGGTTATCACCCTAATGATGTGGAAGA
AGAGTGGGGAAAGCTCATCATAGAGATGCTGGAACGAGAGAAATCACTTCGGCCGGCTGTGGAGAGGCTGGAATTGCTGCTACAGATTGC
AAACAAAATCCAGAATGGTGCTTTGAACTGTGAAGAAAAACTGACACTAGCTAAGAATACACTGCAGGCTGATGCTGCTCACCTGGAATC
AGGACAACCGGTACAATGTGAGTCAGATGTCATTATGTACATTCAGGAGTGTGAAGGTCTCATCAGGCAGCTGCAGGTGGATCTCCAGAT
CCTGCGGGATGAGAATTACTACCAGCTAGAAGAGCTGGCTTTTAGGGTCATGCGTCTTCAGGATGAGCTGGTCACCTTGCGTCTAGAGTG
TACAAACCTGTACCGGAAGGGTCATTTCACTTCACTTGAATTGGTTCCACCCTCTACTTTAACCACCACTCATCTGAAAGCAGAACCCTT
AACCAAGGCAACCCATTCTTCTTCTACCTCCTGGTTCCGAAAGCCTATGACTCGGGCTGAACTTGTGGCCATCAGCTCCTCTGAAGATGA
AGGCAATCTCCGATTTGTGTATGAACTACTGTCTTGGGTAGAAGAGATGCAGATGAAACTGGAGCGAGCAGAGTGGGGCAATGACCTGCC
TAGTGTGGAGTTGCAGCTAGAAACACAGCAGCACATCCATACGAGTGTAGAAGAGCTGGGCTCAAGTGTCAAGGAGGCCAGGTTGTATGA
GGGAAAGATGTCCCAGAATTTCCATACCAGCTATGCTGAAACTCTTGGAAAGCTGGAGACACAGTATTGTAAATTGAAGGAAACTTCTAG
CTTCCGGATGAGGCACCTTCAGAGCCTGCATAAATTTGTTTCCAGAGCTACAGCTGAGTTGATCTGGTTGAATGAGAAGGAGGAGGAGGA
ACTAGCATATGACTGGAGTGACAACAATTCCAATATCTCAGCCAAGAGAAATTACTTCTCTGAGTTGACAATGGAACTGGAGGAGAAACA
GGATGTGTTTCGTTCTCTACAAGATACAGCAGAACTACTTTCACTTGAGAACCACCCAGCCAAGCAGACAGTGGAGGCTTACAGTGCTGC
TGTCCAGTCCCAGTTGCAGTGGATGAAGCAGCTGTGCCTGTGTGTTGAGCAGCATGTGAAAGAGAATACTGCTTATTTTCAGTTCTTCAG
TGATGCACGAGAGCTGGAGTCATTCTTGAGGAACCTCCAAGATTCCATTAAACGAAAATATTCCTGTGACCACAACACCAGCTTATCCCG
CCTTGAAGACCTGCTCCAGGACTCCATGGATGAAAAGGAGCAGCTTATACAGTCCAAGAGTTCCGTTGCCAGTCTCGTTGGGAGATCAAA
AACCATCGTTCAGCTAAAACCACGCAGTCCAGACCATGTGTTAAAGAACACCATTTCTGTCAAGGCTGTCTGTGACTACAGGCAGATCGA
GATTACTATTTGCAAAAATGATGAATGTGTGCTAGAAGATAATTCTCAGCGGACCAAATGGAAAGTGATCAGCCCCACAGGGAACGAGGC
AATGGTGCCGTCAGTCTGCTTCCTCATCCCCCCACCCAATAAGGATGCCATTGAGATGGCCAGCAGGGTCGAACAATCTTATCAGAAGGT
TATGGCCCTTTGGCATCAGCTGCATGTTAACACCAAAAGCCTTATCTCTTGGAACTATCTGCGTAAAGACCTTGACCTTGTACAGACCTG
GAACCTAGAAAAGCTTCGATCCTCAGCACCAGGGGAGTGCCATCAGATTATGAAGAACCTTCAGGCCCACTATGAAGACTTTCTGCAGGA
TAGTCGTGACTCTGTGCTGTTCTCAGTGGCTGATCGCTTGCGCTTGGAAGAGGAGGTGGAAGCTTGTAAAGCCCGCTTCCAGCACCTGAT
GAAGTCCATGGAGAATGAGGACAAAGAGGAGACTGTGGCCAAGATGTACATTTCAGAGTTGAAGAACATCCGGCTACGCCTGGAGGAGTA
TGAACAGAGGGTGGTCAAACGAATTCAGTCTCTAGCCAGCTCTAGGACTGACAGAGATGCCTGGCAGGACAATGCATTAAGGATTGCAGA
GCAAGAGCACACCCAGGAGGATTTACAGCAATTGAGGTCAGACTTGGATGCAGTTTCTATGAAATGTGACAGCTTTCTCCATCAGTCTCC
ATCTAGTTCAAGTGTCCCAACTCTGCGCTCAGAACTGAATCTGCTGGTGGAGAAGATGGACCATGTCTATGGTCTCTCTACTGTATATCT
GAATAAGTTAAAGACAGTTGATGTTATAGTACGTAGCATACAGGATGCTGAACTCTTGGTCAAAGGTTATGAGATTAAGCTGAGTCAAGA
AGAAGTAGTACTGGCAGATCTCTCAGCTCTGGAGGCCCATTGGTCGACATTACGGCACTGGCTTAGTGATGTGAAGGACAAGAATTCAGT
GTTTTCAGTCCTGGATGAGGAAATTGCCAAGGCCAAGGTAGTGGCAGAGCAGATGAGTCGTCTGACACCAGAGCGAAATCTGGATTTGGA
GCGCTATCAGGAAAAAGGCTCCCAGCTGCAGGAGCGTTGGCACCGAGTCATTGCCCAGCTCGAGATTCGCCAATCTGAGCTAGAAAGTAT
CCAGGAAGTTCTGGGAGATTACCGAGCCTGCCATGGAACTCTCATCAAGTGGATTGAGGAAACCACTGCCCAGCAGGAAATGATGAAGCC
AGGCCAGGCAGAGGATAGCAGAGTGCTTTCGGAGCAGCTCAGCCAGCAGACGGCCCTATTTGCAGAAATTGAGAGAAATCAGACAAAACT
GGATCAATGTCAAAAATTTTCCCAGCAGTACTCTACTATTGTAAAGGACTATGAATTGCAACTGATGACATACAAGGCCTTTGTGGAATC
GCAGCAGAAATCCCCTGGCAAGCGCCGTCGCATGCTTTCCTCTTCAGATGCCATCACTCAAGAGTTCATGGACTTAAGGACTCGCTACAC
GGCATTGGTGACTTTAACAACTCAGCACGTGAAATACATCAGTGATGCACTCCGGCGTCTGGAGGAGGAGGAGAAAGTGGTAGAAGAGGA
GAAACAAGAACATGTGGAGAAGGTTAAAGAACTTTTGGGCTGGGTGTCTACCCTAGCGAGGAATACACAAGGAAAAGCTACCTCATCCGA
GACCAAAGAATCAACAGACATTGAAAAAGCTATTTTGGAACAGCAGGTTCTGTCAGAAGAGCTGACAACAAAGAAAGAACAAGTCTCTGA
AGCTATTAAAACATCACAGATCTTCTTGGCCAAGCATGGTCATAAGCTCTCAGAAAAAGAGAAGAAACAAATATCTGAGCAATTGAATGC
CCTAAACAAGGCTTACCATGACCTTTGTGATGGTTCTGCAAATCAGCTTCAGCAGCTTCAGAGCCAGTTGGCTCACCAGACAGAACAAAA
GACCCTGCAGAAACAACAAAATACCTGTCACCAGCAACTGGAGGATCTTTGCAGTTGGGTAGGACAGGCAGAAAGAGCACTGGCAGGCCA
CCAAGGCAGAACCACCCAGCAGGATCTCTCTGCTTTGCAGAAGAACCAAAGTGACTTGAAGGATTTACAGGATGACATTCAGAATCGTGC
CACCTCATTTGCCACTGTTGTCAAGGACATTGAGGGGTTCATGGAAGAGAATCAGACCAAGCTGAGCCCACGTGAGTTGACAGCTCTTCG
GGAAAAGCTTCATCAGGCTAAGGAGCAATATGAGGCGCTCCAGGAAGAGACACGTGTGGCCCAGAAGGAACTGGAGGAAGCAGTGACCTC
CGCCTTACAGCAGGAGACTGAAAAGAGTAAAGCAGCAAAGGAACTGGCAGAGAACAAGAAGAAGATCGATGCTCTCCTGGATTGGGTAAC
TTCAGTAGGATCATCTGGTGGACAGCTGCTGACCAACCTTCCAGGAATGGAGCAGCTCTCGGGAGCTAGCTTGGAGAAAGGAGCCTTGGA
CACCACTGATGGTTACATGGGGGTGAATCAAGCCCCAGAGAAACTGGACAAGCAATGTGAGATGATGAAGGCCCGTCACCAAGAATTGCT
GTCCCAGCAGCAAAATTTCATTCTGGCCACCCAGTCAGCTCAGGCCTTCTTGGATCAGCATGGCCACAATCTCACACCTGAGGAGCAACA
GATGCTGCAACAGAAGCTGGGAGAGCTAAAGGAACAATACTCTACTTCCCTGGCCCAATCAGAGGCAGAACTGAAGCAGGTGCAGACACT
TCAGGATGAGTTGCAGAAATTTCTGCAGGATCATAAAGAGTTTGAAAGCTGGTTGGAACGATCCGAGAAAGAGCTGGAGAACATGCATAA
GGGAGGCAGCAGCCCCGAGACCCTTCCCTCCCTGCTAAAGCGGCAAGGAAGCTTCTCAGAGGATGTCATTTCCCACAAAGGAGACTTGAG
ATTTGTGACTATCTCAGGACAGAAAGTCTTGGACATGGAAAACAGTTTTAAGGAAGGCAAAGAACCATCAGAAATTGGAAACTTAGTAAA
GGACAAGTTGAAGGATGCAACAGAAAGATACACTGCTCTCCACTCAAAGTGTACACGATTAGGATCTCACCTGAATATGCTGTTAGGCCA
GTATCATCAATTCCAAAACAGTGCTGACAGCCTGCAGGCCTGGATGCAGGCTTGTGAGGCCAACGTGGAGAAGCTCCTCTCAGATACTGT
TGCCTCTGACCCTGGAGTTCTCCAGGAGCAGCTTGCAACAACAAAGCAGTTGCAGGAGGAATTGGCTGAGCACCAAGTACCTGTGGAAAA
ACTCCAAAAAGTAGCTCGTGACATAATGGAAATTGAAGGGGAGCCAGCCCCAGACCACAGGCATGTTCAAGAAACTACAGATTCCATACT
CAGCCACTTCCAAAGCCTCTCCTATAGCCTGGCTGAGCGATCTTCTCTGCTGCAGAAAGCAATTGCCCAATCTCAGAGTGTCCAGGAAAG
CCTGGAGAGCCTGTTGCAGTCTATTGGGGAAGTTGAACAAAACCTGGAAGGGAAGCAGGTGTCATCACTCTCATCAGGAGTCATCCAGGA
AGCCTTAGCCACAAATATGAAATTGAAGCAGGACATTGCTCGGCAAAAGAGCAGCTTGGAGGCCACCCGTGAGATGGTGACCCGATTCAT
GGAGACAGCAGACAGTACTACAGCAGCAGTGCTGCAGGGCAAACTGGCAGAGGTGAGCCAGCGGTTCGAACAGCTCTGTCTACAGCAGCA
AGAAAAGGAGAGCTCCCTAAAGAAGCTTCTACCCCAGGCAGAGATGTTTGAACACCTCTCTGGTAAGCTGCAGCAGTTCATGGAAAACAA
AAGTCGGATGCTGGCCTCTGGAAATCAGCCAGATCAAGATATTACACATTTCTTCCAACAGATCCAGGAGCTCAATTTGGAAATGGAAGA
CCAACAGGAGAACCTAGATACTCTTGAGCACCTGGTCACTGAACTGAGCTCTTGTGGCTTTGCGCTGGACTTGTGCCAGCATCAGGACAG
GGTACAGAATCTAAGAAAAGACTTCACAGAGCTACAGAAGACAGTTAAAGAGAGAGAGAAAGATGCATCATCTTGCCAGGAACAGTTGGA
TGAATTCCGGAAGCTGGTCAGGACCTTCCAGAAATGGTTGAAAGAAACTGAAGGGAGTATTCCACCTACGGAAACTTCTATGAGTGCTAA
AGAGTTAGAAAAGCAGATTGAACACCTGAAGAGTCTACTAGATGACTGGGCAAGTAAGGGAACTCTGGTGGAAGAAATCAATTGCAAAGG
TACTTCTTTAGAAAATCTCATCATGGAAATCACAGCACCTGATTCCCAAGGCAAGACAGGTTCCATACTGCCCTCTGTAGGAAGCTCTGT
AGGCAGTGTAAACGGATACCACACCTGCAAAGATCTGACGGAGATCCAGTGTGACATGTCAGATGTAAACTTGAAGTATGAGAAACTAGG
GGGAGTACTTCATGAACGCCAGGAAAGCCTTCAGGCTATCCTCAACAGAATGGAGGAGGTTCACAAGGAGGCAAACTCTGTGCTGCAGTG
GCTGGAATCAAAAGAGGAAGTCCTGAAATCCATGGATGCCATGTCATCTCCAACCAAGACAGAAACAGTGAAAGCCCAAGCTGAATCTAA
CAAGGCCTTCCTGGCTGAGTTGGAACAGAATTCTCCAAAAATTCAAAAAGTAAAGGAAGCCCTGGCTGGATTACTGGTGACATATCCCAA
CTCACAGGAAGCAGAAAATTGGAAGAAAATTCAGGAAGAACTCAATTCCCGATGGGAAAGGGCCACTGAGGTTACTGTGGCTCGGCAAAG
GCAGCTAGAGGAATCTGCAAGTCATCTGGCCTGCTTCCAGGCTGCAGAATCCCAGCTCCGGCCGTGGCTGATGGAGAAAGAACTGATGAT
GGGAGTGCTGGGGCCCCTGTCTATTGACCCCAACATGTTGAATGCACAAAAGCAACAGGTCCAGTTTATGCTAAAGGAATTTGAAGCACG
CAGGCAACAGCATGAGCAACTGAATGAGGCAGCTCAGGGCATCCTAACAGGCCCTGGAGATGTCTCTCTGTCCACCAGCCAAGTACAGAA
AGAACTCCAGAGCATCAATCAGAAATGGGTTGAGCTGACTGACAAACTCAACTCCCGTTCCAGCCAAATTGACCAAGCTATTGTTAAGAG
CACCCAGTACCAGGAACTGCTCCAGGACTTATCAGAGAAGGTGAGGGCAGTTGGACAACGGCTGAGTGTCCAGTCAGCTATCAGCACCCA
ACCAGAGGCTGTAAAGCAGCAATTGGAAGAGACCAGTGAAATTCGATCTGACTTGGAGCAGTTAGACCACGAGGTTAAGGAGGCTCAGAC
ACTGTGCGATGAACTCTCAGTGCTCATTGGTGAGCAGTACCTCAAGGATGAACTGAAGAAGCGTTTGGAGACAGTTGCCCTGCCTCTCCA
AGGTTTAGAAGACCTTGCAGCCGATCGCATTAACAGACTCCAGGCAGCTCTTGCCAGCACCCAGCAGTTCCAGCAAATGTTTGATGAGTT
GAGGACCTGGTTGGATGATAAACAAAGCCAGCAAGCAAAAAACTGCCCAATTTCTGCAAAATTGGAGCGGCTACAGTCTCAGCTACAGGA
GAATGAAGAGTTTCAGAAAAGTCTTAATCAACACAGTGGCTCCTATGAGGTGATTGTGGCTGAAGGGGAATCTCTACTTCTTTCTGTACC
TCCTGGAGAAGAGAAAAGGACTCTACAAAACCAGTTGGTTGAGCTCAAAAACCATTGGGAAGAGCTTAGTAAAAAAACTGCAGACAGACA
ATCCAGGCTCAAGGATTGTATGCAGAAAGCTCAGAAATATCAGTGGCATGTGGAAGACCTTGTGCCATGGATAGAAGATTGTAAAGCTAA
GATGTCTGAGTTGCGAGTCACTCTGGATCCAGTGCAGCTAGAGTCCAGTCTCCTAAGATCAAAGGCTATGCTGAATGAGGTGGAGAAGCG
CCGCTCCCTGCTGGAAATATTGAATAGTGCTGCTGACATTCTGATCAATTCTTCAGAAGCAGATGAGGATGGAATCCGGGATGAGAAGGC
TGGGATCAACCAGAACATGGATGCTGTTACAGAAGAGCTGCAGGCCAAAACAGGGTCACTCGAAGAAATGACTCAGAGGCTCAGGGAGTT
CCAGGAAAGCTTTAAGAATATTGAAAAGAAGGTTGAAGGAGCCAAACACCAACTTGAGATCTTTGATGCTCTGGGTTCTCAAGCCTGTAG
CAACAAGAACCTGGAGAAGCTAAGAGCTCAACAGGAAGTGCTGCAGGCCCTAGAGCCTCAGGTAGACTATCTGAGGAACTTTACTCAGGG
TCTGGTAGAAGATGCCCCAGATGGATCTGATGCTTCTCAACTTCTCCACCAAGCTGAGGTCGCCCAGCAAGAGTTCCTCGAAGTTAAGCA
AAGAGTGAACAGTGGTTGTGTGATGATGGAAAACAAGCTGGAGGGGATTGGCCAGTTTCACTGCCGGGTCCGAGAGATGTTCTCTCAATT
GGCAGACCTGGATGATGAGCTAGATGGCATGGGTGCTATTGGCAGAGACACTGATAGCCTCCAGTCCCAAATCGAGGATGTCCGGCTATT
CCTTAACAAAATTCACGTCCTCAAATTAGACATAGAGGCCTCTGAAGCAGAGTGTCGACATATGCTAGAAGAAGAGGGGACTCTGGATTT
GTTAGGTCTCAAAAGGGAGCTAGAAGCCCTGAACAAACAGTGTGGCAAACTGACAGAGAGGGGGAAAGCTCGTCAGGAACAGCTGGAACT
GACACTAGGCCGTGTAGAGGACTTCTACAGGAAATTGAAAGGACTCAATGACGCGACCACAGCAGCAGAGGAGGCAGAGGCCCTCCAGTG
GGTAGTGGGGACCGAAGTGGAAATCATCAACCAACAATTAGCAGATTTTAAAATGTTTCAGAAAGAACAAGTGGATCCTCTTCAGATGAA
ATTGCAGCAGGTGAATGGACTTGGCCAGGGATTAATTCAGAGTGCAGGAAAAGACTGTGATGTACAGGGTTTAGAACATGACATGGAAGA
GATCAATGCTCGATGGAATACATTGAATAAAAAGGTCGCACAAAGAATTGCACAGCTACAGGAAGCTTTGTTGCATTGTGGGAAGTTTCA
AGATGCCTTGGAGCCATTGCTCAGCTGGTTGGCAGATACCGAGGAGCTCATAGCCAATCAGAAACCTCCATCTGCTGAGTATAAAGTGGT
GAAAGCACAGATCCAAGAACAGAAGTTGCTCCAGCGGCTCCTAGATGATCGAAAGGCCACAGTAGACATGCTTCAAGCAGAAGGAGGCAG
AATAGCCCAGTCAGCAGAGCTGGCTGATAGAGAGAAAATCACTGGACAGCTGGAGAGTCTTGAAAGTAGATGGACTGAACTACTCAGTAA
GGCAGCAGCCAGGCAAAAACAGCTGGAAGACATCCTGGTTCTGGCCAAACAGTTCCATGAGACAGCTGAGCCTATTTCTGACTTCTTATC
TGTCACAGAGAAAAAGCTTGCTAACTCAGAACCTGTTGGCACTCAGACTGCCAAAATACAGCAGCAGATCATTCGGCACAAGGCTCTGGA
AGAAGACATAGAAAACCATGCAACAGATGTGCACCAGGCAGTCAAAATTGGGCAGTCCCTCTCCTCCCTGACATCTCCTGCAGAACAGGG
TGTGCTGTCAGAAAAGATAGACTCATTGCAGGCCCGATACAGTGAAATTCAAGACCGCTGTTGTCGGAAGGCAGCCCTACTTGACCAAGC
TCTGTCTAATGCTAGGCTGTTTGGGGAGGATGAGGTGGAGGTGCTCAACTGGCTGGCTGAGGTTGAGGACAAGCTCAGTTCAGTGTTCGT
AAAGGATTTCAAACAGGATGTCCTGCACAGGCAGCATGCTGACCACCTGGCTTTAAATGAAGAAATTGTTAATAGAAAGAAGAATGTAGA
TCAAGCTATTAAAAATGGTCAGGCTCTTCTAAAACAAACCACAGGTGAGGAGGTGTTACTTATCCAGGAAAAACTAGATGGTATAAAGAC
TCGTTACGCAGACATCACAGTTACTAGCTCCAAGGCCCTCAGAACTTTAGAGCAAGCCCGGCAGCTGGCCACCAAGTTCCAGTCTACTTA
TGAGGAACTGACCGGGTGGCTGAGGGAGGTGGAGGAGGAGCTGGCAACCAGTGGAGGACAGTCTCCCACAGGGGAACAGATACCCCAGTT
TCAGCAGAGACAGAAGGAATTAAAGAAGGAGGTCATGGAGCACAGGCTGGTGTTGGACACAGTGAATGAGGTGAGCCGTGCTCTCTTAGA
GCTGGTGCCCTGGAGAGCCAGAGAAGGGCTGGATAAACTTGTGTCCGATGCTAACGAGCAGTACAAACTAGTCAGTGACACTATTGGACA
AAGGGTGGATGAAATTGATGCTGCTATTCAGAGATCACAACAGGACTTGATTAGAGACCAAGGATTTCGTGGTGATGGAGGATCAACCAC
AGGTTTGTCTGCTACCCCCCCTGCCTCATTACCTGGCTCACTAACTAACGTGAAAGCCTTACAGAAATCTCCAGGACCTCAGCGAGAAAG
GAAGTCATCTTCATCCTCAGAAGACAGGAATCGAATGAAAACACTTGGTAGACGGGACTCGAGTGATGATTGGGAGATTCCTGATGGGCA
GATTACAGTGGGACAAAGAATTGGATCTGGATCATTTGGAACAGTCTACAAGGGAAAGTGGCATGGTGATGTGGCAGTGAAAATGTTGAA
TGTGACAGCACCTACACCTCAGCAGTTACAAGCCTTCAAAAATGAAGTAGGAGTACTCAGGAAAACACGACATGTGAATATCCTACTCTT
CATGGGCTATTCCACAAAGCCACAACTGGCTATTGTTACCCAGTGGTGTGAGGGCTCCAGCTTGTATCACCATCTCCATATCATTGAGAC
CAAATTTGAGATGATCAAACTTATAGATATTGCACGACAGACTGCACAGGGCATGGATTACTTACACGCCAAGTCAATCATCCACAGAGA
CCTCAAGAGTAATAATATATTTCTTCATGAAGACCTCACAGTAAAAATAGGTGATTTTGGTCTAGCTACAGTGAAATCTCGATGGAGTGG
GTCCCATCAGTTTGAACAGTTGTCTGGATCCATTTTGTGGATGGCACCAGAAGTCATCAGAATGCAAGATAAAAATCCATACAGCTTTCA
GTCAGATGTATATGCATTTGGAATTGTTCTGTATGAATTGATGACTGGACAGTTACCTTATTCAAACATCAACAACAGGGACCAGATAAT
TTTTATGGTGGGACGAGGATACCTGTCTCCAGATCTCAGTAAGGTACGGAGTAACTGTCCAAAAGCCATGAAGAGATTAATGGCAGAGTG
CCTCAAAAAGAAAAGAGATGAGAGACCACTCTTTCCCCAAATTCTCGCCTCTATTGAGCTGCTGGCCCGCTCATTGCCAAAAATTCACCG
CAGTGCATCAGAACCCTCCTTGAATCGGGCTGGTTTCCAAACAGAGGATTTTAGTCTATATGCTTGTGCTTCTCCAAAAACACCCATCCA
GGCAGGGGGATATGGTGCGTTTCCTGTCCACTGAAACAAATGAGTGAGAGAGTTCAGGAGAGTAGCAACAAAAGGAAAATAAATGAACAT

>50588_50588_2_MACF1-BRAF_MACF1_chr1_39896580_ENST00000317713_BRAF_chr7_140487384_ENST00000288602_length(amino acids)=4103AA_BP=3717
MSSSDEETLSERSCRSERSCRSERSYRSERSGSLSPCPPGDTLPWNLPLHEQKKRKSQDSVLDPAERAVVRVADERDRVQKKTFTKWVNK
HLMKVRKHINDLYEDLRDGHNLISLLEVLSGIKLPREKGRMRFHRLQNVQIALDFLKQRQVKLVNIRNDDITDGNPKLTLGLIWTIILHF
QISDIYISGESGDMSAKEKLLLWTQKVTAGYTGIKCTNFSSCWSDGKMFNALIHRYRPDLVDMERVQIQSNRENLEQAFEVAERLGVTRL
LDAEDVDVPSPDEKSVITYVSSIYDAFPKVPEGGEGISATEVDSRWQEYQSRVDSLIPWIKQHTILMSDKTFPQNPVELKALYNQYIHFK
ETEILAKEREKGRIEELYKLLEVWIEFGRIKLPQGYHPNDVEEEWGKLIIEMLEREKSLRPAVERLELLLQIANKIQNGALNCEEKLTLA
KNTLQADAAHLESGQPVQCESDVIMYIQECEGLIRQLQVDLQILRDENYYQLEELAFRVMRLQDELVTLRLECTNLYRKGHFTSLELVPP
STLTTTHLKAEPLTKATHSSSTSWFRKPMTRAELVAISSSEDEGNLRFVYELLSWVEEMQMKLERAEWGNDLPSVELQLETQQHIHTSVE
ELGSSVKEARLYEGKMSQNFHTSYAETLGKLETQYCKLKETSSFRMRHLQSLHKFVSRATAELIWLNEKEEEELAYDWSDNNSNISAKRN
YFSELTMELEEKQDVFRSLQDTAELLSLENHPAKQTVEAYSAAVQSQLQWMKQLCLCVEQHVKENTAYFQFFSDARELESFLRNLQDSIK
RKYSCDHNTSLSRLEDLLQDSMDEKEQLIQSKSSVASLVGRSKTIVQLKPRSPDHVLKNTISVKAVCDYRQIEITICKNDECVLEDNSQR
TKWKVISPTGNEAMVPSVCFLIPPPNKDAIEMASRVEQSYQKVMALWHQLHVNTKSLISWNYLRKDLDLVQTWNLEKLRSSAPGECHQIM
KNLQAHYEDFLQDSRDSVLFSVADRLRLEEEVEACKARFQHLMKSMENEDKEETVAKMYISELKNIRLRLEEYEQRVVKRIQSLASSRTD
RDAWQDNALRIAEQEHTQEDLQQLRSDLDAVSMKCDSFLHQSPSSSSVPTLRSELNLLVEKMDHVYGLSTVYLNKLKTVDVIVRSIQDAE
LLVKGYEIKLSQEEVVLADLSALEAHWSTLRHWLSDVKDKNSVFSVLDEEIAKAKVVAEQMSRLTPERNLDLERYQEKGSQLQERWHRVI
AQLEIRQSELESIQEVLGDYRACHGTLIKWIEETTAQQEMMKPGQAEDSRVLSEQLSQQTALFAEIERNQTKLDQCQKFSQQYSTIVKDY
ELQLMTYKAFVESQQKSPGKRRRMLSSSDAITQEFMDLRTRYTALVTLTTQHVKYISDALRRLEEEEKVVEEEKQEHVEKVKELLGWVST
LARNTQGKATSSETKESTDIEKAILEQQVLSEELTTKKEQVSEAIKTSQIFLAKHGHKLSEKEKKQISEQLNALNKAYHDLCDGSANQLQ
QLQSQLAHQTEQKTLQKQQNTCHQQLEDLCSWVGQAERALAGHQGRTTQQDLSALQKNQSDLKDLQDDIQNRATSFATVVKDIEGFMEEN
QTKLSPRELTALREKLHQAKEQYEALQEETRVAQKELEEAVTSALQQETEKSKAAKELAENKKKIDALLDWVTSVGSSGGQLLTNLPGME
QLSGASLEKGALDTTDGYMGVNQAPEKLDKQCEMMKARHQELLSQQQNFILATQSAQAFLDQHGHNLTPEEQQMLQQKLGELKEQYSTSL
AQSEAELKQVQTLQDELQKFLQDHKEFESWLERSEKELENMHKGGSSPETLPSLLKRQGSFSEDVISHKGDLRFVTISGQKVLDMENSFK
EGKEPSEIGNLVKDKLKDATERYTALHSKCTRLGSHLNMLLGQYHQFQNSADSLQAWMQACEANVEKLLSDTVASDPGVLQEQLATTKQL
QEELAEHQVPVEKLQKVARDIMEIEGEPAPDHRHVQETTDSILSHFQSLSYSLAERSSLLQKAIAQSQSVQESLESLLQSIGEVEQNLEG
KQVSSLSSGVIQEALATNMKLKQDIARQKSSLEATREMVTRFMETADSTTAAVLQGKLAEVSQRFEQLCLQQQEKESSLKKLLPQAEMFE
HLSGKLQQFMENKSRMLASGNQPDQDITHFFQQIQELNLEMEDQQENLDTLEHLVTELSSCGFALDLCQHQDRVQNLRKDFTELQKTVKE
REKDASSCQEQLDEFRKLVRTFQKWLKETEGSIPPTETSMSAKELEKQIEHLKSLLDDWASKGTLVEEINCKGTSLENLIMEITAPDSQG
KTGSILPSVGSSVGSVNGYHTCKDLTEIQCDMSDVNLKYEKLGGVLHERQESLQAILNRMEEVHKEANSVLQWLESKEEVLKSMDAMSSP
TKTETVKAQAESNKAFLAELEQNSPKIQKVKEALAGLLVTYPNSQEAENWKKIQEELNSRWERATEVTVARQRQLEESASHLACFQAAES
QLRPWLMEKELMMGVLGPLSIDPNMLNAQKQQVQFMLKEFEARRQQHEQLNEAAQGILTGPGDVSLSTSQVQKELQSINQKWVELTDKLN
SRSSQIDQAIVKSTQYQELLQDLSEKVRAVGQRLSVQSAISTQPEAVKQQLEETSEIRSDLEQLDHEVKEAQTLCDELSVLIGEQYLKDE
LKKRLETVALPLQGLEDLAADRINRLQAALASTQQFQQMFDELRTWLDDKQSQQAKNCPISAKLERLQSQLQENEEFQKSLNQHSGSYEV
IVAEGESLLLSVPPGEEKRTLQNQLVELKNHWEELSKKTADRQSRLKDCMQKAQKYQWHVEDLVPWIEDCKAKMSELRVTLDPVQLESSL
LRSKAMLNEVEKRRSLLEILNSAADILINSSEADEDGIRDEKAGINQNMDAVTEELQAKTGSLEEMTQRLREFQESFKNIEKKVEGAKHQ
LEIFDALGSQACSNKNLEKLRAQQEVLQALEPQVDYLRNFTQGLVEDAPDGSDASQLLHQAEVAQQEFLEVKQRVNSGCVMMENKLEGIG
QFHCRVREMFSQLADLDDELDGMGAIGRDTDSLQSQIEDVRLFLNKIHVLKLDIEASEAECRHMLEEEGTLDLLGLKRELEALNKQCGKL
TERGKARQEQLELTLGRVEDFYRKLKGLNDATTAAEEAEALQWVVGTEVEIINQQLADFKMFQKEQVDPLQMKLQQVNGLGQGLIQSAGK
DCDVQGLEHDMEEINARWNTLNKKVAQRIAQLQEALLHCGKFQDALEPLLSWLADTEELIANQKPPSAEYKVVKAQIQEQKLLQRLLDDR
KATVDMLQAEGGRIAQSAELADREKITGQLESLESRWTELLSKAAARQKQLEDILVLAKQFHETAEPISDFLSVTEKKLANSEPVGTQTA
KIQQQIIRHKALEEDIENHATDVHQAVKIGQSLSSLTSPAEQGVLSEKIDSLQARYSEIQDRCCRKAALLDQALSNARLFGEDEVEVLNW
LAEVEDKLSSVFVKDFKQDVLHRQHADHLALNEEIVNRKKNVDQAIKNGQALLKQTTGEEVLLIQEKLDGIKTRYADITVTSSKALRTLE
QARQLATKFQSTYEELTGWLREVEEELATSGGQSPTGEQIPQFQQRQKELKKEVMEHRLVLDTVNEVSRALLELVPWRAREGLDKLVSDA
NEQYKLVSDTIGQRVDEIDAAIQRSQQDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGR
RDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCE
GSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPE
VIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILAS

--------------------------------------------------------------
>50588_50588_3_MACF1-BRAF_MACF1_chr1_39896580_ENST00000361689_BRAF_chr7_140487384_ENST00000288602_length(transcript)=12482nt_BP=11203nt
ATCACTTCTCCCTGGGCTCCCAGGCCCTCCTGCAGCAGCCCCCGCCTGGGCCATGTCTTCCTCAGATGAAGAGACGCTCAGTGAGCGGTC
ATGTCGGAGTGAGCGGTCTTGTCGGAGTGAGCGATCTTACAGGAGCGAGCGGTCGGGGAGCCTGTCTCCCTGTCCCCCAGGGGACACCTT
GCCCTGGAACCTGCCACTGCATGAGCAGAAAAAGCGGAAAAGCCAGGATTCGGTGCTGGACCCTGCAGAGCGTGCTGTGGTCAGAGTCGC
TGATGAACGGGACCGGGTTCAGAAGAAAACGTTCACCAAGTGGGTCAACAAGCACTTAATGAAGGTCCGCAAGCACATCAATGATCTTTA
TGAAGATCTGCGGGATGGCCATAACCTGATCTCTCTGTTGGAGGTCCTCTCAGGCATCAAACTGCCCCGGGAGAAGGGCAGGATGCGTTT
TCATAGGCTGCAGAATGTGCAGATTGCCCTGGACTTCCTAAAGCAGCGACAGGTGAAACTAGTGAATATTCGCAATGATGACATCACAGA
TGGCAACCCCAAGTTGACCCTGGGTCTGATCTGGACCATTATTTTGCATTTCCAGATCTCTGACATCTACATTAGTGGAGAATCAGGGGA
TATGTCAGCCAAGGAGAAACTACTCCTGTGGACCCAGAAGGTGACAGCTGGTTACACAGGAATCAAATGCACCAACTTTTCCTCCTGCTG
GAGTGATGGGAAGATGTTCAATGCACTCATTCACCGATACCGACCCGATCTAGTAGACATGGAGAGGGTGCAAATCCAAAGTAACCGAGA
GAATCTGGAACAGGCTTTTGAAGTGGCAGAAAGACTGGGGGTCACTCGCCTGCTGGATGCAGAAGATGTGGATGTGCCATCTCCAGATGA
AAAGTCTGTAATCACTTATGTGTCTTCGATTTATGATGCCTTCCCTAAAGTTCCTGAGGGTGGAGAAGGGATCAGTGCTACGGAAGTGGA
CTCCAGGTGGCAAGAATACCAAAGCCGAGTGGACTCCCTCATTCCCTGGATCAAACAGCATACAATACTGATGTCAGATAAAACTTTTCC
CCAAAACCCTGTTGAACTAAAGGCACTTTATAACCAATATATACACTTCAAAGAAACAGAAATTCTGGCCAAGGAGAGAGAAAAAGGAAG
AATTGAGGAATTATATAAATTACTAGAGGTGTGGATTGAATTTGGCCGAATTAAACTGCCTCAAGGTTATCACCCTAATGATGTGGAAGA
AGAGTGGGGAAAGCTCATCATAGAGATGCTGGAACGAGAGAAATCACTTCGGCCGGCTGTGGAGAGGCTGGAATTGCTGCTACAGATTGC
AAACAAAATCCAGAATGGTGCTTTGAACTGTGAAGAAAAACTGACACTAGCTAAGAATACACTGCAGGCTGATGCTGCTCACCTGGAATC
AGGACAACCGGTACAATGTGAGTCAGATGTCATTATGTACATTCAGGAGTGTGAAGGTCTCATCAGGCAGCTGCAGGTGGATCTCCAGAT
CCTGCGGGATGAGAATTACTACCAGCTAGAAGAGCTGGCTTTTAGGGTCATGCGTCTTCAGGATGAGCTGGTCACCTTGCGTCTAGAGTG
TACAAACCTGTACCGGAAGGGTCATTTCACTTCACTTGAATTGGTTCCACCCTCTACTTTAACCACCACTCATCTGAAAGCAGAACCCTT
AACCAAGGCAACCCATTCTTCTTCTACCTCCTGGTTCCGAAAGCCTATGACTCGGGCTGAACTTGTGGCCATCAGCTCCTCTGAAGATGA
AGGCAATCTCCGATTTGTGTATGAACTACTGTCTTGGGTAGAAGAGATGCAGATGAAACTGGAGCGAGCAGAGTGGGGCAATGACCTGCC
TAGTGTGGAGTTGCAGCTAGAAACACAGCAGCACATCCATACGAGTGTAGAAGAGCTGGGCTCAAGTGTCAAGGAGGCCAGGTTGTATGA
GGGAAAGATGTCCCAGAATTTCCATACCAGCTATGCTGAAACTCTTGGAAAGCTGGAGACACAGTATTGTAAATTGAAGGAAACTTCTAG
CTTCCGGATGAGGCACCTTCAGAGCCTGCATAAATTTGTTTCCAGAGCTACAGCTGAGTTGATCTGGTTGAATGAGAAGGAGGAGGAGGA
ACTAGCATATGACTGGAGTGACAACAATTCCAATATCTCAGCCAAGAGAAATTACTTCTCTGAGTTGACAATGGAACTGGAGGAGAAACA
GGATGTGTTTCGTTCTCTACAAGATACAGCAGAACTACTTTCACTTGAGAACCACCCAGCCAAGCAGACAGTGGAGGCTTACAGTGCTGC
TGTCCAGTCCCAGTTGCAGTGGATGAAGCAGCTGTGCCTGTGTGTTGAGCAGCATGTGAAAGAGAATACTGCTTATTTTCAGTTCTTCAG
TGATGCACGAGAGCTGGAGTCATTCTTGAGGAACCTCCAAGATTCCATTAAACGAAAATATTCCTGTGACCACAACACCAGCTTATCCCG
CCTTGAAGACCTGCTCCAGGACTCCATGGATGAAAAGGAGCAGCTTATACAGTCCAAGAGTTCCGTTGCCAGTCTCGTTGGGAGATCAAA
AACCATCGTTCAGCTAAAACCACGCAGTCCAGACCATGTGTTAAAGAACACCATTTCTGTCAAGGCTGTCTGTGACTACAGGCAGATCGA
GATTACTATTTGCAAAAATGATGAATGTGTGCTAGAAGATAATTCTCAGCGGACCAAATGGAAAGTGATCAGCCCCACAGGGAACGAGGC
AATGGTGCCGTCAGTCTGCTTCCTCATCCCCCCACCCAATAAGGATGCCATTGAGATGGCCAGCAGGGTCGAACAATCTTATCAGAAGGT
TATGGCCCTTTGGCATCAGCTGCATGTTAACACCAAAAGCCTTATCTCTTGGAACTATCTGCGTAAAGACCTTGACCTTGTACAGACCTG
GAACCTAGAAAAGCTTCGATCCTCAGCACCAGGGGAGTGCCATCAGATTATGAAGAACCTTCAGGCCCACTATGAAGACTTTCTGCAGGA
TAGTCGTGACTCTGTGCTGTTCTCAGTGGCTGATCGCTTGCGCTTGGAAGAGGAGGTGGAAGCTTGTAAAGCCCGCTTCCAGCACCTGAT
GAAGTCCATGGAGAATGAGGACAAAGAGGAGACTGTGGCCAAGATGTACATTTCAGAGTTGAAGAACATCCGGCTACGCCTGGAGGAGTA
TGAACAGAGGGTGGTCAAACGAATTCAGTCTCTAGCCAGCTCTAGGACTGACAGAGATGCCTGGCAGGACAATGCATTAAGGATTGCAGA
GCAAGAGCACACCCAGGAGGATTTACAGCAATTGAGGTCAGACTTGGATGCAGTTTCTATGAAATGTGACAGCTTTCTCCATCAGTCTCC
ATCTAGTTCAAGTGTCCCAACTCTGCGCTCAGAACTGAATCTGCTGGTGGAGAAGATGGACCATGTCTATGGTCTCTCTACTGTATATCT
GAATAAGTTAAAGACAGTTGATGTTATAGTACGTAGCATACAGGATGCTGAACTCTTGGTCAAAGGTTATGAGATTAAGCTGAGTCAAGA
AGAAGTAGTACTGGCAGATCTCTCAGCTCTGGAGGCCCATTGGTCGACATTACGGCACTGGCTTAGTGATGTGAAGGACAAGAATTCAGT
GTTTTCAGTCCTGGATGAGGAAATTGCCAAGGCCAAGGTAGTGGCAGAGCAGATGAGTCGTCTGACACCAGAGCGAAATCTGGATTTGGA
GCGCTATCAGGAAAAAGGCTCCCAGCTGCAGGAGCGTTGGCACCGAGTCATTGCCCAGCTCGAGATTCGCCAATCTGAGCTAGAAAGTAT
CCAGGAAGTTCTGGGAGATTACCGAGCCTGCCATGGAACTCTCATCAAGTGGATTGAGGAAACCACTGCCCAGCAGGAAATGATGAAGCC
AGGCCAGGCAGAGGATAGCAGAGTGCTTTCGGAGCAGCTCAGCCAGCAGACGGCCCTATTTGCAGAAATTGAGAGAAATCAGACAAAACT
GGATCAATGTCAAAAATTTTCCCAGCAGTACTCTACTATTGTAAAGGACTATGAATTGCAACTGATGACATACAAGGCCTTTGTGGAATC
GCAGCAGAAATCCCCTGGCAAGCGCCGTCGCATGCTTTCCTCTTCAGATGCCATCACTCAAGAGTTCATGGACTTAAGGACTCGCTACAC
GGCATTGGTGACTTTAACAACTCAGCACGTGAAATACATCAGTGATGCACTCCGGCGTCTGGAGGAGGAGGAGAAAGTGGTAGAAGAGGA
GAAACAAGAACATGTGGAGAAGGTTAAAGAACTTTTGGGCTGGGTGTCTACCCTAGCGAGGAATACACAAGGAAAAGCTACCTCATCCGA
GACCAAAGAATCAACAGACATTGAAAAAGCTATTTTGGAACAGCAGGTTCTGTCAGAAGAGCTGACAACAAAGAAAGAACAAGTCTCTGA
AGCTATTAAAACATCACAGATCTTCTTGGCCAAGCATGGTCATAAGCTCTCAGAAAAAGAGAAGAAACAAATATCTGAGCAATTGAATGC
CCTAAACAAGGCTTACCATGACCTTTGTGATGGTTCTGCAAATCAGCTTCAGCAGCTTCAGAGCCAGTTGGCTCACCAGACAGAACAAAA
GACCCTGCAGAAACAACAAAATACCTGTCACCAGCAACTGGAGGATCTTTGCAGTTGGGTAGGACAGGCAGAAAGAGCACTGGCAGGCCA
CCAAGGCAGAACCACCCAGCAGGATCTCTCTGCTTTGCAGAAGAACCAAAGTGACTTGAAGGATTTACAGGATGACATTCAGAATCGTGC
CACCTCATTTGCCACTGTTGTCAAGGACATTGAGGGGTTCATGGAAGAGAATCAGACCAAGCTGAGCCCACGTGAGTTGACAGCTCTTCG
GGAAAAGCTTCATCAGGCTAAGGAGCAATATGAGGCGCTCCAGGAAGAGACACGTGTGGCCCAGAAGGAACTGGAGGAAGCAGTGACCTC
CGCCTTACAGCAGGAGACTGAAAAGAGTAAAGCAGCAAAGGAACTGGCAGAGAACAAGAAGAAGATCGATGCTCTCCTGGATTGGGTAAC
TTCAGTAGGATCATCTGGTGGACAGCTGCTGACCAACCTTCCAGGAATGGAGCAGCTCTCGGGAGCTAGCTTGGAGAAAGGAGCCTTGGA
CACCACTGATGGTTACATGGGGGTGAATCAAGCCCCAGAGAAACTGGACAAGCAATGTGAGATGATGAAGGCCCGTCACCAAGAATTGCT
GTCCCAGCAGCAAAATTTCATTCTGGCCACCCAGTCAGCTCAGGCCTTCTTGGATCAGCATGGCCACAATCTCACACCTGAGGAGCAACA
GATGCTGCAACAGAAGCTGGGAGAGCTAAAGGAACAATACTCTACTTCCCTGGCCCAATCAGAGGCAGAACTGAAGCAGGTGCAGACACT
TCAGGATGAGTTGCAGAAATTTCTGCAGGATCATAAAGAGTTTGAAAGCTGGTTGGAACGATCCGAGAAAGAGCTGGAGAACATGCATAA
GGGAGGCAGCAGCCCCGAGACCCTTCCCTCCCTGCTAAAGCGGCAAGGAAGCTTCTCAGAGGATGTCATTTCCCACAAAGGAGACTTGAG
ATTTGTGACTATCTCAGGACAGAAAGTCTTGGACATGGAAAACAGTTTTAAGGAAGGCAAAGAACCATCAGAAATTGGAAACTTAGTAAA
GGACAAGTTGAAGGATGCAACAGAAAGATACACTGCTCTCCACTCAAAGTGTACACGATTAGGATCTCACCTGAATATGCTGTTAGGCCA
GTATCATCAATTCCAAAACAGTGCTGACAGCCTGCAGGCCTGGATGCAGGCTTGTGAGGCCAACGTGGAGAAGCTCCTCTCAGATACTGT
TGCCTCTGACCCTGGAGTTCTCCAGGAGCAGCTTGCAACAACAAAGCAGTTGCAGGAGGAATTGGCTGAGCACCAAGTACCTGTGGAAAA
ACTCCAAAAAGTAGCTCGTGACATAATGGAAATTGAAGGGGAGCCAGCCCCAGACCACAGGCATGTTCAAGAAACTACAGATTCCATACT
CAGCCACTTCCAAAGCCTCTCCTATAGCCTGGCTGAGCGATCTTCTCTGCTGCAGAAAGCAATTGCCCAATCTCAGAGTGTCCAGGAAAG
CCTGGAGAGCCTGTTGCAGTCTATTGGGGAAGTTGAACAAAACCTGGAAGGGAAGCAGGTGTCATCACTCTCATCAGGAGTCATCCAGGA
AGCCTTAGCCACAAATATGAAATTGAAGCAGGACATTGCTCGGCAAAAGAGCAGCTTGGAGGCCACCCGTGAGATGGTGACCCGATTCAT
GGAGACAGCAGACAGTACTACAGCAGCAGTGCTGCAGGGCAAACTGGCAGAGGTGAGCCAGCGGTTCGAACAGCTCTGTCTACAGCAGCA
AGAAAAGGAGAGCTCCCTAAAGAAGCTTCTACCCCAGGCAGAGATGTTTGAACACCTCTCTGGTAAGCTGCAGCAGTTCATGGAAAACAA
AAGTCGGATGCTGGCCTCTGGAAATCAGCCAGATCAAGATATTACACATTTCTTCCAACAGATCCAGGAGCTCAATTTGGAAATGGAAGA
CCAACAGGAGAACCTAGATACTCTTGAGCACCTGGTCACTGAACTGAGCTCTTGTGGCTTTGCGCTGGACTTGTGCCAGCATCAGGACAG
GGTACAGAATCTAAGAAAAGACTTCACAGAGCTACAGAAGACAGTTAAAGAGAGAGAGAAAGATGCATCATCTTGCCAGGAACAGTTGGA
TGAATTCCGGAAGCTGGTCAGGACCTTCCAGAAATGGTTGAAAGAAACTGAAGGGAGTATTCCACCTACGGAAACTTCTATGAGTGCTAA
AGAGTTAGAAAAGCAGATTGAACACCTGAAGAGTCTACTAGATGACTGGGCAAGTAAGGGAACTCTGGTGGAAGAAATCAATTGCAAAGG
TACTTCTTTAGAAAATCTCATCATGGAAATCACAGCACCTGATTCCCAAGGCAAGACAGGTTCCATACTGCCCTCTGTAGGAAGCTCTGT
AGGCAGTGTAAACGGATACCACACCTGCAAAGATCTGACGGAGATCCAGTGTGACATGTCAGATGTAAACTTGAAGTATGAGAAACTAGG
GGGAGTACTTCATGAACGCCAGGAAAGCCTTCAGGCTATCCTCAACAGAATGGAGGAGGTTCACAAGGAGGCAAACTCTGTGCTGCAGTG
GCTGGAATCAAAAGAGGAAGTCCTGAAATCCATGGATGCCATGTCATCTCCAACCAAGACAGAAACAGTGAAAGCCCAAGCTGAATCTAA
CAAGGCCTTCCTGGCTGAGTTGGAACAGAATTCTCCAAAAATTCAAAAAGTAAAGGAAGCCCTGGCTGGATTACTGGTGACATATCCCAA
CTCACAGGAAGCAGAAAATTGGAAGAAAATTCAGGAAGAACTCAATTCCCGATGGGAAAGGGCCACTGAGGTTACTGTGGCTCGGCAAAG
GCAGCTAGAGGAATCTGCAAGTCATCTGGCCTGCTTCCAGGCTGCAGAATCCCAGCTCCGGCCGTGGCTGATGGAGAAAGAACTGATGAT
GGGAGTGCTGGGGCCCCTGTCTATTGACCCCAACATGTTGAATGCACAAAAGCAACAGGTCCAGTTTATGCTAAAGGAATTTGAAGCACG
CAGGCAACAGCATGAGCAACTGAATGAGGCAGCTCAGGGCATCCTAACAGGCCCTGGAGATGTCTCTCTGTCCACCAGCCAAGTACAGAA
AGAACTCCAGAGCATCAATCAGAAATGGGTTGAGCTGACTGACAAACTCAACTCCCGTTCCAGCCAAATTGACCAAGCTATTGTTAAGAG
CACCCAGTACCAGGAACTGCTCCAGGACTTATCAGAGAAGGTGAGGGCAGTTGGACAACGGCTGAGTGTCCAGTCAGCTATCAGCACCCA
ACCAGAGGCTGTAAAGCAGCAATTGGAAGAGACCAGTGAAATTCGATCTGACTTGGAGCAGTTAGACCACGAGGTTAAGGAGGCTCAGAC
ACTGTGCGATGAACTCTCAGTGCTCATTGGTGAGCAGTACCTCAAGGATGAACTGAAGAAGCGTTTGGAGACAGTTGCCCTGCCTCTCCA
AGGTTTAGAAGACCTTGCAGCCGATCGCATTAACAGACTCCAGGCAGCTCTTGCCAGCACCCAGCAGTTCCAGCAAATGTTTGATGAGTT
GAGGACCTGGTTGGATGATAAACAAAGCCAGCAAGCAAAAAACTGCCCAATTTCTGCAAAATTGGAGCGGCTACAGTCTCAGCTACAGGA
GAATGAAGAGTTTCAGAAAAGTCTTAATCAACACAGTGGCTCCTATGAGGTGATTGTGGCTGAAGGGGAATCTCTACTTCTTTCTGTACC
TCCTGGAGAAGAGAAAAGGACTCTACAAAACCAGTTGGTTGAGCTCAAAAACCATTGGGAAGAGCTTAGTAAAAAAACTGCAGACAGACA
ATCCAGGCTCAAGGATTGTATGCAGAAAGCTCAGAAATATCAGTGGCATGTGGAAGACCTTGTGCCATGGATAGAAGATTGTAAAGCTAA
GATGTCTGAGTTGCGAGTCACTCTGGATCCAGTGCAGCTAGAGTCCAGTCTCCTAAGATCAAAGGCTATGCTGAATGAGGTGGAGAAGCG
CCGCTCCCTGCTGGAAATATTGAATAGTGCTGCTGACATTCTGATCAATTCTTCAGAAGCAGATGAGGATGGAATCCGGGATGAGAAGGC
TGGGATCAACCAGAACATGGATGCTGTTACAGAAGAGCTGCAGGCCAAAACAGGGTCACTCGAAGAAATGACTCAGAGGCTCAGGGAGTT
CCAGGAAAGCTTTAAGAATATTGAAAAGAAGGTTGAAGGAGCCAAACACCAACTTGAGATCTTTGATGCTCTGGGTTCTCAAGCCTGTAG
CAACAAGAACCTGGAGAAGCTAAGAGCTCAACAGGAAGTGCTGCAGGCCCTAGAGCCTCAGGTAGACTATCTGAGGAACTTTACTCAGGG
TCTGGTAGAAGATGCCCCAGATGGATCTGATGCTTCTCAACTTCTCCACCAAGCTGAGGTCGCCCAGCAAGAGTTCCTCGAAGTTAAGCA
AAGAGTGAACAGTGGTTGTGTGATGATGGAAAACAAGCTGGAGGGGATTGGCCAGTTTCACTGCCGGGTCCGAGAGATGTTCTCTCAATT
GGCAGACCTGGATGATGAGCTAGATGGCATGGGTGCTATTGGCAGAGACACTGATAGCCTCCAGTCCCAAATCGAGGATGTCCGGCTATT
CCTTAACAAAATTCACGTCCTCAAATTAGACATAGAGGCCTCTGAAGCAGAGTGTCGACATATGCTAGAAGAAGAGGGGACTCTGGATTT
GTTAGGTCTCAAAAGGGAGCTAGAAGCCCTGAACAAACAGTGTGGCAAACTGACAGAGAGGGGGAAAGCTCGTCAGGAACAGCTGGAACT
GACACTAGGCCGTGTAGAGGACTTCTACAGGAAATTGAAAGGACTCAATGACGCGACCACAGCAGCAGAGGAGGCAGAGGCCCTCCAGTG
GGTAGTGGGGACCGAAGTGGAAATCATCAACCAACAATTAGCAGATTTTAAAATGTTTCAGAAAGAACAAGTGGATCCTCTTCAGATGAA
ATTGCAGCAGGTGAATGGACTTGGCCAGGGATTAATTCAGAGTGCAGGAAAAGACTGTGATGTACAGGGTTTAGAACATGACATGGAAGA
GATCAATGCTCGATGGAATACATTGAATAAAAAGGTCGCACAAAGAATTGCACAGCTACAGGAAGCTTTGTTGCATTGTGGGAAGTTTCA
AGATGCCTTGGAGCCATTGCTCAGCTGGTTGGCAGATACCGAGGAGCTCATAGCCAATCAGAAACCTCCATCTGCTGAGTATAAAGTGGT
GAAAGCACAGATCCAAGAACAGAAGTTGCTCCAGCGGCTCCTAGATGATCGAAAGGCCACAGTAGACATGCTTCAAGCAGAAGGAGGCAG
AATAGCCCAGTCAGCAGAGCTGGCTGATAGAGAGAAAATCACTGGACAGCTGGAGAGTCTTGAAAGTAGATGGACTGAACTACTCAGTAA
GGCAGCAGCCAGGCAAAAACAGCTGGAAGACATCCTGGTTCTGGCCAAACAGTTCCATGAGACAGCTGAGCCTATTTCTGACTTCTTATC
TGTCACAGAGAAAAAGCTTGCTAACTCAGAACCTGTTGGCACTCAGACTGCCAAAATACAGCAGCAGATCATTCGGCACAAGGCTCTGGA
AGAAGACATAGAAAACCATGCAACAGATGTGCACCAGGCAGTCAAAATTGGGCAGTCCCTCTCCTCCCTGACATCTCCTGCAGAACAGGG
TGTGCTGTCAGAAAAGATAGACTCATTGCAGGCCCGATACAGTGAAATTCAAGACCGCTGTTGTCGGAAGGCAGCCCTACTTGACCAAGC
TCTGTCTAATGCTAGGCTGTTTGGGGAGGATGAGGTGGAGGTGCTCAACTGGCTGGCTGAGGTTGAGGACAAGCTCAGTTCAGTGTTCGT
AAAGGATTTCAAACAGGATGTCCTGCACAGGCAGCATGCTGACCACCTGGCTTTAAATGAAGAAATTGTTAATAGAAAGAAGAATGTAGA
TCAAGCTATTAAAAATGGTCAGGCTCTTCTAAAACAAACCACAGGTGAGGAGGTGTTACTTATCCAGGAAAAACTAGATGGTATAAAGAC
TCGTTACGCAGACATCACAGTTACTAGCTCCAAGGCCCTCAGAACTTTAGAGCAAGCCCGGCAGCTGGCCACCAAGTTCCAGTCTACTTA
TGAGGAACTGACCGGGTGGCTGAGGGAGGTGGAGGAGGAGCTGGCAACCAGTGGAGGACAGTCTCCCACAGGGGAACAGATACCCCAGTT
TCAGCAGAGACAGAAGGAATTAAAGAAGGAGGTCATGGAGCACAGGCTGGTGTTGGACACAGTGAATGAGGTGAGCCGTGCTCTCTTAGA
GCTGGTGCCCTGGAGAGCCAGAGAAGGGCTGGATAAACTTGTGTCCGATGCTAACGAGCAGTACAAACTAGTCAGTGACACTATTGGACA
AAGGGTGGATGAAATTGATGCTGCTATTCAGAGATCACAACAGGACTTGATTAGAGACCAAGGATTTCGTGGTGATGGAGGATCAACCAC
AGGTTTGTCTGCTACCCCCCCTGCCTCATTACCTGGCTCACTAACTAACGTGAAAGCCTTACAGAAATCTCCAGGACCTCAGCGAGAAAG
GAAGTCATCTTCATCCTCAGAAGACAGGAATCGAATGAAAACACTTGGTAGACGGGACTCGAGTGATGATTGGGAGATTCCTGATGGGCA
GATTACAGTGGGACAAAGAATTGGATCTGGATCATTTGGAACAGTCTACAAGGGAAAGTGGCATGGTGATGTGGCAGTGAAAATGTTGAA
TGTGACAGCACCTACACCTCAGCAGTTACAAGCCTTCAAAAATGAAGTAGGAGTACTCAGGAAAACACGACATGTGAATATCCTACTCTT
CATGGGCTATTCCACAAAGCCACAACTGGCTATTGTTACCCAGTGGTGTGAGGGCTCCAGCTTGTATCACCATCTCCATATCATTGAGAC
CAAATTTGAGATGATCAAACTTATAGATATTGCACGACAGACTGCACAGGGCATGGATTACTTACACGCCAAGTCAATCATCCACAGAGA
CCTCAAGAGTAATAATATATTTCTTCATGAAGACCTCACAGTAAAAATAGGTGATTTTGGTCTAGCTACAGTGAAATCTCGATGGAGTGG
GTCCCATCAGTTTGAACAGTTGTCTGGATCCATTTTGTGGATGGCACCAGAAGTCATCAGAATGCAAGATAAAAATCCATACAGCTTTCA
GTCAGATGTATATGCATTTGGAATTGTTCTGTATGAATTGATGACTGGACAGTTACCTTATTCAAACATCAACAACAGGGACCAGATAAT
TTTTATGGTGGGACGAGGATACCTGTCTCCAGATCTCAGTAAGGTACGGAGTAACTGTCCAAAAGCCATGAAGAGATTAATGGCAGAGTG
CCTCAAAAAGAAAAGAGATGAGAGACCACTCTTTCCCCAAATTCTCGCCTCTATTGAGCTGCTGGCCCGCTCATTGCCAAAAATTCACCG
CAGTGCATCAGAACCCTCCTTGAATCGGGCTGGTTTCCAAACAGAGGATTTTAGTCTATATGCTTGTGCTTCTCCAAAAACACCCATCCA
GGCAGGGGGATATGGTGCGTTTCCTGTCCACTGAAACAAATGAGTGAGAGAGTTCAGGAGAGTAGCAACAAAAGGAAAATAAATGAACAT

>50588_50588_3_MACF1-BRAF_MACF1_chr1_39896580_ENST00000361689_BRAF_chr7_140487384_ENST00000288602_length(amino acids)=4103AA_BP=3717
MSSSDEETLSERSCRSERSCRSERSYRSERSGSLSPCPPGDTLPWNLPLHEQKKRKSQDSVLDPAERAVVRVADERDRVQKKTFTKWVNK
HLMKVRKHINDLYEDLRDGHNLISLLEVLSGIKLPREKGRMRFHRLQNVQIALDFLKQRQVKLVNIRNDDITDGNPKLTLGLIWTIILHF
QISDIYISGESGDMSAKEKLLLWTQKVTAGYTGIKCTNFSSCWSDGKMFNALIHRYRPDLVDMERVQIQSNRENLEQAFEVAERLGVTRL
LDAEDVDVPSPDEKSVITYVSSIYDAFPKVPEGGEGISATEVDSRWQEYQSRVDSLIPWIKQHTILMSDKTFPQNPVELKALYNQYIHFK
ETEILAKEREKGRIEELYKLLEVWIEFGRIKLPQGYHPNDVEEEWGKLIIEMLEREKSLRPAVERLELLLQIANKIQNGALNCEEKLTLA
KNTLQADAAHLESGQPVQCESDVIMYIQECEGLIRQLQVDLQILRDENYYQLEELAFRVMRLQDELVTLRLECTNLYRKGHFTSLELVPP
STLTTTHLKAEPLTKATHSSSTSWFRKPMTRAELVAISSSEDEGNLRFVYELLSWVEEMQMKLERAEWGNDLPSVELQLETQQHIHTSVE
ELGSSVKEARLYEGKMSQNFHTSYAETLGKLETQYCKLKETSSFRMRHLQSLHKFVSRATAELIWLNEKEEEELAYDWSDNNSNISAKRN
YFSELTMELEEKQDVFRSLQDTAELLSLENHPAKQTVEAYSAAVQSQLQWMKQLCLCVEQHVKENTAYFQFFSDARELESFLRNLQDSIK
RKYSCDHNTSLSRLEDLLQDSMDEKEQLIQSKSSVASLVGRSKTIVQLKPRSPDHVLKNTISVKAVCDYRQIEITICKNDECVLEDNSQR
TKWKVISPTGNEAMVPSVCFLIPPPNKDAIEMASRVEQSYQKVMALWHQLHVNTKSLISWNYLRKDLDLVQTWNLEKLRSSAPGECHQIM
KNLQAHYEDFLQDSRDSVLFSVADRLRLEEEVEACKARFQHLMKSMENEDKEETVAKMYISELKNIRLRLEEYEQRVVKRIQSLASSRTD
RDAWQDNALRIAEQEHTQEDLQQLRSDLDAVSMKCDSFLHQSPSSSSVPTLRSELNLLVEKMDHVYGLSTVYLNKLKTVDVIVRSIQDAE
LLVKGYEIKLSQEEVVLADLSALEAHWSTLRHWLSDVKDKNSVFSVLDEEIAKAKVVAEQMSRLTPERNLDLERYQEKGSQLQERWHRVI
AQLEIRQSELESIQEVLGDYRACHGTLIKWIEETTAQQEMMKPGQAEDSRVLSEQLSQQTALFAEIERNQTKLDQCQKFSQQYSTIVKDY
ELQLMTYKAFVESQQKSPGKRRRMLSSSDAITQEFMDLRTRYTALVTLTTQHVKYISDALRRLEEEEKVVEEEKQEHVEKVKELLGWVST
LARNTQGKATSSETKESTDIEKAILEQQVLSEELTTKKEQVSEAIKTSQIFLAKHGHKLSEKEKKQISEQLNALNKAYHDLCDGSANQLQ
QLQSQLAHQTEQKTLQKQQNTCHQQLEDLCSWVGQAERALAGHQGRTTQQDLSALQKNQSDLKDLQDDIQNRATSFATVVKDIEGFMEEN
QTKLSPRELTALREKLHQAKEQYEALQEETRVAQKELEEAVTSALQQETEKSKAAKELAENKKKIDALLDWVTSVGSSGGQLLTNLPGME
QLSGASLEKGALDTTDGYMGVNQAPEKLDKQCEMMKARHQELLSQQQNFILATQSAQAFLDQHGHNLTPEEQQMLQQKLGELKEQYSTSL
AQSEAELKQVQTLQDELQKFLQDHKEFESWLERSEKELENMHKGGSSPETLPSLLKRQGSFSEDVISHKGDLRFVTISGQKVLDMENSFK
EGKEPSEIGNLVKDKLKDATERYTALHSKCTRLGSHLNMLLGQYHQFQNSADSLQAWMQACEANVEKLLSDTVASDPGVLQEQLATTKQL
QEELAEHQVPVEKLQKVARDIMEIEGEPAPDHRHVQETTDSILSHFQSLSYSLAERSSLLQKAIAQSQSVQESLESLLQSIGEVEQNLEG
KQVSSLSSGVIQEALATNMKLKQDIARQKSSLEATREMVTRFMETADSTTAAVLQGKLAEVSQRFEQLCLQQQEKESSLKKLLPQAEMFE
HLSGKLQQFMENKSRMLASGNQPDQDITHFFQQIQELNLEMEDQQENLDTLEHLVTELSSCGFALDLCQHQDRVQNLRKDFTELQKTVKE
REKDASSCQEQLDEFRKLVRTFQKWLKETEGSIPPTETSMSAKELEKQIEHLKSLLDDWASKGTLVEEINCKGTSLENLIMEITAPDSQG
KTGSILPSVGSSVGSVNGYHTCKDLTEIQCDMSDVNLKYEKLGGVLHERQESLQAILNRMEEVHKEANSVLQWLESKEEVLKSMDAMSSP
TKTETVKAQAESNKAFLAELEQNSPKIQKVKEALAGLLVTYPNSQEAENWKKIQEELNSRWERATEVTVARQRQLEESASHLACFQAAES
QLRPWLMEKELMMGVLGPLSIDPNMLNAQKQQVQFMLKEFEARRQQHEQLNEAAQGILTGPGDVSLSTSQVQKELQSINQKWVELTDKLN
SRSSQIDQAIVKSTQYQELLQDLSEKVRAVGQRLSVQSAISTQPEAVKQQLEETSEIRSDLEQLDHEVKEAQTLCDELSVLIGEQYLKDE
LKKRLETVALPLQGLEDLAADRINRLQAALASTQQFQQMFDELRTWLDDKQSQQAKNCPISAKLERLQSQLQENEEFQKSLNQHSGSYEV
IVAEGESLLLSVPPGEEKRTLQNQLVELKNHWEELSKKTADRQSRLKDCMQKAQKYQWHVEDLVPWIEDCKAKMSELRVTLDPVQLESSL
LRSKAMLNEVEKRRSLLEILNSAADILINSSEADEDGIRDEKAGINQNMDAVTEELQAKTGSLEEMTQRLREFQESFKNIEKKVEGAKHQ
LEIFDALGSQACSNKNLEKLRAQQEVLQALEPQVDYLRNFTQGLVEDAPDGSDASQLLHQAEVAQQEFLEVKQRVNSGCVMMENKLEGIG
QFHCRVREMFSQLADLDDELDGMGAIGRDTDSLQSQIEDVRLFLNKIHVLKLDIEASEAECRHMLEEEGTLDLLGLKRELEALNKQCGKL
TERGKARQEQLELTLGRVEDFYRKLKGLNDATTAAEEAEALQWVVGTEVEIINQQLADFKMFQKEQVDPLQMKLQQVNGLGQGLIQSAGK
DCDVQGLEHDMEEINARWNTLNKKVAQRIAQLQEALLHCGKFQDALEPLLSWLADTEELIANQKPPSAEYKVVKAQIQEQKLLQRLLDDR
KATVDMLQAEGGRIAQSAELADREKITGQLESLESRWTELLSKAAARQKQLEDILVLAKQFHETAEPISDFLSVTEKKLANSEPVGTQTA
KIQQQIIRHKALEEDIENHATDVHQAVKIGQSLSSLTSPAEQGVLSEKIDSLQARYSEIQDRCCRKAALLDQALSNARLFGEDEVEVLNW
LAEVEDKLSSVFVKDFKQDVLHRQHADHLALNEEIVNRKKNVDQAIKNGQALLKQTTGEEVLLIQEKLDGIKTRYADITVTSSKALRTLE
QARQLATKFQSTYEELTGWLREVEEELATSGGQSPTGEQIPQFQQRQKELKKEVMEHRLVLDTVNEVSRALLELVPWRAREGLDKLVSDA
NEQYKLVSDTIGQRVDEIDAAIQRSQQDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGR
RDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCE
GSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPE
VIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILAS

--------------------------------------------------------------
>50588_50588_4_MACF1-BRAF_MACF1_chr1_39896580_ENST00000372915_BRAF_chr7_140487384_ENST00000288602_length(transcript)=18391nt_BP=17112nt
TTTTGTCTGCTCACATTCACCCCTTTCTCCTTCAGATCACTTCTCCCTGGGCTCCCAGGCCCTCCTGCAGCAGCCCCCGCCTGGGCCATG
TCTTCCTCAGATGAAGAGACGCTCAGTGAGCGGTCATGTCGGAGTGAGCGGTCTTGTCGGAGTGAGCGATCTTACAGGAGCGAGCGGTCG
GGGAGCCTGTCTCCCTGTCCCCCAGGGGACACCTTGCCCTGGAACCTGCCACTGCATGAGCAGAAAAAGCGGAAAAGCCAGGATTCGGTG
CTGGACCCTGCAGAGCGTGCTGTGGTCAGAGTCGCTGATGAACGGGACCGGGTTCAGAAGAAAACGTTCACCAAGTGGGTCAACAAGCAC
TTAATGAAGGTCCGCAAGCACATCAATGATCTTTATGAAGATCTGCGGGATGGCCATAACCTGATCTCTCTGTTGGAGGTCCTCTCAGGC
ATCAAACTGCCCCGGGAGAAGGGCAGGATGCGTTTTCATAGGCTGCAGAATGTGCAGATTGCCCTGGACTTCCTAAAGCAGCGACAGGTG
AAACTAGTGAATATTCGCAATGATGACATCACAGATGGCAACCCCAAGTTGACCCTGGGTCTGATCTGGACCATTATTTTGCATTTCCAG
ATCTCTGACATCTACATTAGTGGAGAATCAGGGGATATGTCAGCCAAGGAGAAACTACTCCTGTGGACCCAGAAGGTGACAGCTGGTTAC
ACAGGAATCAAATGCACCAACTTTTCCTCCTGCTGGAGTGATGGGAAGATGTTCAATGCACTCATTCACCGATACCGACCCGATCTAGTA
GACATGGAGAGGGTGCAAATCCAAAGTAACCGAGAGAATCTGGAACAGGCTTTTGAAGTGGCAGAAAGACTGGGGGTCACTCGCCTGCTG
GATGCAGAAGATGTGGATGTGCCATCTCCAGATGAAAAGTCTGTAATCACTTATGTGTCTTCGATTTATGATGCCTTCCCTAAAGTTCCT
GAGGGTGGAGAAGGGATCAGTGCTACGGAAGTGGACTCCAGGTGGCAAGAATACCAAAGCCGAGTGGACTCCCTCATTCCCTGGATCAAA
CAGCATACAATACTGATGTCAGATAAAACTTTTCCCCAAAACCCTGTTGAACTAAAGGCACTTTATAACCAATATATACACTTCAAAGAA
ACAGAAATTCTGGCCAAGGAGAGAGAAAAAGGAAGAATTGAGGAATTATATAAATTACTAGAGGTGTGGATTGAATTTGGCCGAATTAAA
CTGCCTCAAGGTTATCACCCTAATGATGTGGAAGAAGAGTGGGGAAAGCTCATCATAGAGATGCTGGAACGAGAGAAATCACTTCGGCCG
GCTGTGGAGAGGCTGGAATTGCTGCTACAGATTGCAAACAAAATCCAGAATGGTGCTTTGAACTGTGAAGAAAAACTGACACTAGCTAAG
AATACACTGCAGGCTGATGCTGCTCACCTGGAATCAGGACAACCGGTACAATGTGAGTCAGATGTCATTATGTACATTCAGGAGTGTGAA
GGTCTCATCAGGCAGCTGCAGGTGGATCTCCAGATCCTGCGGGATGAGAATTACTACCAGCTAGAAGAGCTGGCTTTTAGGGTCATGCGT
CTTCAGGATGAGCTGGTCACCTTGCGTCTAGAGTGTACAAACCTGTACCGGAAGGGTCATTTCACTTCACTTGAATTGGTTCCACCCTCT
ACTTTAACCACCACTCATCTGAAAGCAGAACCCTTAACCAAGGCAACCCATTCTTCTTCTACCTCCTGGTTCCGAAAGCCTATGACTCGG
GCTGAACTTGTGGCCATCAGCTCCTCTGAAGATGAAGGCAATCTCCGATTTGTGTATGAACTACTGTCTTGGGTAGAAGAGATGCAGATG
AAACTGGAGCGAGCAGAGTGGGGCAATGACCTGCCTAGTGTGGAGTTGCAGCTAGAAACACAGCAGCACATCCATACGAGTGTAGAAGAG
CTGGGCTCAAGTGTCAAGGAGGCCAGGTTGTATGAGGGAAAGATGTCCCAGAATTTCCATACCAGCTATGCTGAAACTCTTGGAAAGCTG
GAGACACAGTATTGTAAATTGAAGGAAACTTCTAGCTTCCGGATGAGGCACCTTCAGAGCCTGCATAAATTTGTTTCCAGAGCTACAGCT
GAGTTGATCTGGTTGAATGAGAAGGAGGAGGAGGAACTAGCATATGACTGGAGTGACAACAATTCCAATATCTCAGCCAAGAGAAATTAC
TTCTCTGAGTTGACAATGGAACTGGAGGAGAAACAGGATGTGTTTCGTTCTCTACAAGATACAGCAGAACTACTTTCACTTGAGAACCAC
CCAGCCAAGCAGACAGTGGAGGCTTACAGTGCTGCTGTCCAGTCCCAGTTGCAGTGGATGAAGCAGCTGTGCCTGTGTGTTGAGCAGCAT
GTGAAAGAGAATACTGCTTATTTTCAGTTCTTCAGTGATGCACGAGAGCTGGAGTCATTCTTGAGGAACCTCCAAGATTCCATTAAACGA
AAATATTCCTGTGACCACAACACCAGCTTATCCCGCCTTGAAGACCTGCTCCAGGACTCCATGGATGAAAAGGAGCAGCTTATACAGTCC
AAGAGTTCCGTTGCCAGTCTCGTTGGGAGATCAAAAACCATCGTTCAGCTAAAACCACGCAGTCCAGACCATGTGTTAAAGAACACCATT
TCTGTCAAGGCTGTCTGTGACTACAGGCAGATCGAGATTACTATTTGCAAAAATGATGAATGTGTGCTAGAAGATAATTCTCAGCGGACC
AAATGGAAAGTGATCAGCCCCACAGGGAACGAGGCAATGGTGCCGTCAGTCTGCTTCCTCATCCCCCCACCCAATAAGGATGCCATTGAG
ATGGCCAGCAGGGTCGAACAATCTTATCAGAAGGTTATGGCCCTTTGGCATCAGCTGCATGTTAACACCAAAAGCCTTATCTCTTGGAAC
TATCTGCGTAAAGACCTTGACCTTGTACAGACCTGGAACCTAGAAAAGCTTCGATCCTCAGCACCAGGGGAGTGCCATCAGATTATGAAG
AACCTTCAGGCCCACTATGAAGACTTTCTGCAGGATAGTCGTGACTCTGTGCTGTTCTCAGTGGCTGATCGCTTGCGCTTGGAAGAGGAG
GTGGAAGCTTGTAAAGCCCGCTTCCAGCACCTGATGAAGTCCATGGAGAATGAGGACAAAGAGGAGACTGTGGCCAAGATGTACATTTCA
GAGTTGAAGAACATCCGGCTACGCCTGGAGGAGTATGAACAGAGGGTGGTCAAACGAATTCAGTCTCTAGCCAGCTCTAGGACTGACAGA
GATGCCTGGCAGGACAATGCATTAAGGATTGCAGAGCAAGAGCACACCCAGGAGGATTTACAGCAATTGAGGTCAGACTTGGATGCAGTT
TCTATGAAATGTGACAGCTTTCTCCATCAGTCTCCATCTAGTTCAAGTGTCCCAACTCTGCGCTCAGAACTGAATCTGCTGGTGGAGAAG
ATGGACCATGTCTATGGTCTCTCTACTGTATATCTGAATAAGTTAAAGACAGTTGATGTTATAGTACGTAGCATACAGGATGCTGAACTC
TTGGTCAAAGGTTATGAGATTAAGCTGAGTCAAGAAGAAGTAGTACTGGCAGATCTCTCAGCTCTGGAGGCCCATTGGTCGACATTACGG
CACTGGCTTAGTGATGTGAAGGACAAGAATTCAGTGTTTTCAGTCCTGGATGAGGAAATTGCCAAGGCCAAGGTAGTGGCAGAGCAGATG
AGTCGTCTGACACCAGAGCGAAATCTGGATTTGGAGCGCTATCAGGAAAAAGGCTCCCAGCTGCAGGAGCGTTGGCACCGAGTCATTGCC
CAGCTCGAGATTCGCCAATCTGAGCTAGAAAGTATCCAGGAAGTTCTGGGAGATTACCGAGCCTGCCATGGAACTCTCATCAAGTGGATT
GAGGAAACCACTGCCCAGCAGGAAATGATGAAGCCAGGCCAGGCAGAGGATAGCAGAGTGCTTTCGGAGCAGCTCAGCCAGCAGACGGCC
CTATTTGCAGAAATTGAGAGAAATCAGACAAAACTGGATCAATGTCAAAAATTTTCCCAGCAGTACTCTACTATTGTAAAGGACTATGAA
TTGCAACTGATGACATACAAGGCCTTTGTGGAATCGCAGCAGAAATCCCCTGGCAAGCGCCGTCGCATGCTTTCCTCTTCAGATGCCATC
ACTCAAGAGTTCATGGACTTAAGGACTCGCTACACGGCATTGGTGACTTTAACAACTCAGCACGTGAAATACATCAGTGATGCACTCCGG
CGTCTGGAGGAGGAGGAGAAAGTGGTAGAAGAGGAGAAACAAGAACATGTGGAGAAGGTTAAAGAACTTTTGGGCTGGGTGTCTACCCTA
GCGAGGAATACACAAGGAAAAGCTACCTCATCCGAGACCAAAGAATCAACAGACATTGAAAAAGCTATTTTGGAACAGCAGGTTCTGTCA
GAAGAGCTGACAACAAAGAAAGAACAAGTCTCTGAAGCTATTAAAACATCACAGATCTTCTTGGCCAAGCATGGTCATAAGCTCTCAGAA
AAAGAGAAGAAACAAATATCTGAGCAATTGAATGCCCTAAACAAGGCTTACCATGACCTTTGTGATGGTTCTGCAAATCAGCTTCAGCAG
CTTCAGAGCCAGTTGGCTCACCAGACAGAACAAAAGGAATGCAGAGCAGTTGCTGGGGTGATTGACCTAGGCACAGTGGAGATATTTCCC
ATCTTCAAAGCCATGCAAAAGGGCCTCCTTGACCAAGACACAGGCCTAGTGCTTCTGGAATCTCAGGTTATCATGTCTGGCCTCATTGCC
CCTGAGACGGGTGAAAACCTCTCTTTGGAGGAGGGCATAGCCAGAAACCTCATTAATCCCCAGATGTACCAGCAGCTCCGGGAGCTACAG
GATGCCCTGGCCTTAATAAGCAGGCTTACTGAGAGCAGAGGCCCTCTTTCTGTGGTGGAAGCAATTGAAAAGAGAATAATCAGTGAGACA
GTTGGACTGAAAATCTTAGAAGCTCACCTGGCAACTGGAGGTTTCAGTCTTTCCCCTAGTGAGAACTGTATTAACCTGGAAGAGGCTTTT
CATCAAGGCCTCATTTCTGCATGGCTTCATTCAGTATTAGAGTCTTATCTTAGAACATCCAAGAATTTGATAGACCCTAACACAGCTGAG
AAAATTGGTTTGCTGGATCTGATGCAGCGATGTATTGTCCACCAGGAATCAGGATTCAAATTACTGCCTGTCAAACAATTGGCAGGGGGG
ATGGTGAGCTTGAAATCAGGCCGGAAGGTTAGCATTTTCCGTGCAGTTCAGGAAGGGCTAATAGATAGGCAGGTCACTGTCCGGTTGCTG
GAAGCTCAGCTTTTTGCTGGTGGCATAGTAGATCCAAGAACAGGACACAGACTTACAGTGGAAGAGGCTGTAAGACATAATCTGATTGAC
CAAGATATGGCCTGTGCTATCCTCATAAGGCAGCTTCAGACAGGAGGCATCATAGACACTGTCACGGGGCAAAGGCTAACAATAGATGAA
GCAGTGAGCAATGATCTAGTAGCTGCTAAGATCGCCCTTGTGATTCTGGAGTCCCTCTGGTCATTCATGGGGTTGCTGTGGCCTGAATCT
GGAGAGATCCTCCCAATTACAGATGCCCTAGAACAAGGTATTGTGTCTACTGAACTAGCACATAAAATCCTTAGTAACCGACAGCATATT
AAGGCTCTGTTTCTACCAGCAACCACAGAGATTTTGTCCTGGAAGAAAGCAATAGAAAGTGGTATCCTGGATAGAGATCTTGCCAATAAC
TTAAAATCGATTTGTATACCTGATGTGATGCCCCACATGCAACTAGCAGACTCTGCAGAACAAAATATTAATCCTGGAGCAGCAGTTCTA
CCGTGCAGCAAGAGCCACCCTAAGGCCACAGCAAGCCAGAGTGAGAATCTGTTGTTCCAGCTGATGACTCACAGCTATATTAATGTGCAA
AATGGACAGAGGCTGCTTCTGTTAGATAAAGAGCTGATGGAGACACTAACATCCAGAGATGAGTATCAAACAAGTCCTCCAAAAGTGGTT
GAAATTGGGCATCAAAGGCAAAAAACTCCTGAGGGATTGCAAGAATCAGCTAATGTGAAAATCTCAGGAACTTTCAGCAGTGGGTGGACT
GTGAGGCTGCCTGAGTTCCAGTTTTCTTCTCAGAACAAAGAATATCCCGATCGGGAAGATTGCACTACAGAAAAAGGCAAAAAGACCACT
GTAGAAACAGAAGATTCTTCTGTAGAGAACCCTGAACAGGATCTGTTTGTAGAACAAAAAGAGAGAAATCCAAACATTGATGCTTTGAAG
GTAATAAATAAAGTCAAATTAGAGGTACAAAGGCAGTTGATAGGTACCCAAAGGGAAGACCAAACAGCAGTGTCTGTCAGAGAAAATGCC
AGCAGGGGACACCTCCTGACCATACCTCCTGCTGAGGCGGAAGGTGTGCCGTTGGTGGTTGACAAAGATGTTTTTTCTGTTGAAACACCA
AAGAAAGAACATCAACCTCTAAGAAACACTTCCTTTACATGTCAGAATGAACAAGCACACACTCTTGAGACTGAATATATTCATGATGAA
ACTGGAGGATCTCACATAAAACCCCAAAGCAAAAAGTTACAAGTTCAGGTAAAGAAAACTCTAGGTATAAAGTTAGAACTAAAGTCTGAA
ACTGATGGGAATGTTCATCCTCTGGACAAAAAGGAAATGTTAAAGAAAACATTTCTGGCTAAGGATGACCATAAAGAAAGTCAAGAAGCA
CAGAACATCGCAGGTGGTAGTATGATGATGTCAGAAAAGACCGATGAGGAAGATAGTGGCAGGGAAATTTTTCTGTCATGCAGTCATCCA
TTAGAATTGCTTGAAGAAGCTACCTTAAATGTATTATCTGCACAGTTACTAGATGGTGGTATCTTTCATGAACAAACAGGTCAAAAGCTC
TTACTAAATGAAGCAATATCCCGAGGCATTGTGCCAAGTCACACTGCCGTGAAGCTTATGGAGAAGCTGAACATGTTTCAGGGGTTCTTT
GACTCTCAGACTTGTGAGTCTTTGACAACTGAAGAAGTCATTAATGAAGGTCTGATGGATGAGAAATTATTACATAATGTCCTCATGGCA
GACAAAGCTATAAGTGGTGTCTTAGACCCCCGTACCCAGACACTGTGCTCTGTAAAGGATGCAGTTACAGTTGGACTTCTTGACAAGGAA
ACAGCCACCAGAATTTTAGAGAGGCAGGTGGTGACTGGTGGAATTATTGATCTGAAACGAGGCAAAAAAGTTTCAGTAACTTTGGCCTCA
ACTCTTGGCTTGGTGGACGTTGCTGACCAGCCAGAACTTATAAATCTGGAGAAAGCTTCCAAAGGTAGAGATGCTGAAAAAACAGTTAGG
GAGAGATTAATTAGTTTACAAATGGAAACAACAGGACTTATAGACCCTGATAGTAAAGCACCTTTAACAGTTGTGCAGTCCATTGACAGA
GGTCTTTTGGAGAGAGAGGAGGCCGTTCGTTTGTTGACTAAGCAAGTGGTAGATGGAGGTATCATTCACCATATATCTGGGATGAGACTT
TCTGTTGATAATGCCTTCAGACATGGCTTAATTGGTGAAGATTTAGCCGAGAAACTCAAAAGAGTTGAGAACTTAAACATCCATCAGATT
TTTAATCCTGAAACGAAGGAAAATATTTCCCTCCCTAAAGCCATAAAATTAGATCTTATTACCTCAGACCTGAAAAGAGAAATCCAGGAG
GTTCAGGCCTTTACTGGAAACTTTGTGGATCTCATTTCTGGTCAGAGATTGACCTTGGCAGAAGCTAAAAAAGAAGGACTGTTAACTAAT
GAAGCAGTATTGTCTCCAGGAATGATGCATGGCATTGTAGATCCCGAGAACTGCAGAATTGTCCCCTACTCAGAATTAGTCAAGAAATGT
AAGATTGATATTGAATCTGGACAGAGATATCTAGAAGTAATTCCCTTCTCAGACATTAAAGATGGGGTGAGCGACAAAGTGCTTACATTG
TCTCAAGCAATTCAGCTTGGAAAAGTAGACTTTGCATCTACGCTGAAGGTTCTAGAAGCCCAGGCAAATACTGGTGGAATCATAGATACT
GCTACTGGAAAAAGACTGACATTGGCATCAGCTTTGGAAGAGAAACTGGTGGATGAAAACATGGTCAGAATTATTGCATCTCATCAGGTG
TTAAATGGAGGAATTGTTGACATATTTAGTGATCAGAGAGTGACTTTAGTAGAAGCTATTGAGAAAAGACTGATCAGCCCTGAACTGGCA
AATATGATCCAAATAGATAGTTCAGAGTTCAGCGATCACAGGGCTCAGATTGAAAAGCAAGAAGGGATTGAAGTGTGTGCATTACAAAAT
GAATTTCTAGGAAAGGATATGTTAATTGCTTGTAATCAGACTGCTGAAATGAGTTGTAATAAAGTAGAAGAGAGTGAGAGATTATTTCAA
GTTGAAAATCAGTCTGCACAAGAAAAGGTTAAAGTGAGAGTTTCTGATGGGGAGCAGGCAAAAAAGAGCAGGGAAATTTCCTTAAAGGAA
TTTGGGTGCAAGGATCAACGTAAGCCAAGAATGTCTTCAGATGCTAAAGAATTTATCAGTATCATAAATCCTCATAATCTTAAAGGTAAA
TCCTTGGGCCAAGTGTCATTGACACACCCTTACTCTGAATGTGATTTTAAACTTAAAGAAGTGGCTAGAAATAACATGGGAAATGATACA
AATGAAGAGCAGGAAAAAGCAGTGACAAAAATAGAAATTATTTCTCATATGAAGCAGTCTACCTCATGTCTAGATTCTGAAGAAATAAGA
GAAAATCAAGGGGAAGTGATTTTGGAAGTACAAGAAACATATTGTGAAACGTCAGGCAAATTGCCGAGTGAGCAGGTTTTGCAGCAACCA
ATGAATGCTCGGGTGAAAAGTAAGAGAGAGAAGAGGGAGGTGATTGTAGAAGAAAGTATCAGAACATGCAAACCAGCATTTCTTTCTGAA
GAAAAGTTGTATCAGGAAACTGCCATTAGAGATGAGCATGACTCCCATATAAAGAGCCAACCTAGGGAAATGACCTCAAGTGAAAAAGGG
AAAGAAGCTGATACAGAAATGGGATTTTCTATTACTTTTAAAATTGAAGAGTCCTCTTCCCAAGTGGTACCTCAAGGAATTTCTGTAAAA
CATTTAGATGCTTTAACACTCTTCAGCTCTAAACAGGCCAATGAAGGAAAAGTAAACAATTTAAGTCTCTGCTTGACTTTAAAACCAGAA
GAAAACTTATCTCGAGAAATTGCCTGTGGGGCCCAGAGTGAACCATTCCCTTGTATGACCCCAAGACCTGAAGGATTGCACTACCAGGAA
TCAGATGGAAAAGCCCAAGTGACAGGCCCATCCCAAATTTCCAAAACAGACAAGTCTTTCCAAGGAACCACCAGACAGGAGACCAACTAT
CAAGATTCCTGGGTTACTTCGAAAACTAAGGAAACCAAACATCAAATTTCCTCATCTAATGAATGTAAAGAAAAGTCATACCAAGAAGTA
TCTTTTGACCCAGCAAGAGGTCTTAAATTGGAAGAAATCACAGTTTCTAGACCAGATTCAAAAGAAGTCAGGTATCTAGAATTCTCAGAC
AGAAAAGACCTTCATCATCAGGGCAGCAAAAGTGATGATAAACTTTGTGGAACTCTCAAATCTGAAATAGCAACACAGGAACTAACTGGA
GAGAAATTTCTAGAAATGGCAAACCCTAATGTTGCAGGTCTAGAAGCAGGATCCATTGAGGACATAGTGACTCAGAGAGGTTCCAGAGTC
TTGGGATCCTTTCTTCCAGAGAAACTGTTCAAAGGAGTGTCTCAAAAAGAGAATACAGGGCAACAGAATGCCATCATTAGTCCTACTGTT
CTAGAGACCAGTGAAGAAAAGACAGTGTCCCTAACAGTATGCTCTGCAGTGAAGACAGAGAAGACACCACAGGAAAAGCTCAGAGAAAGC
CCTGGCAGTGAACAAACTCCCTTCATGACTGCACCTGAAGGAAAGGGAAATGGAGGTGTAAACCCAGAGCCCTTCAGAGCAACTCAGAAT
GTATTTACCCGGCAACTCTGTTTAGAACATGATGAAAAGCTAGTATCCTATCTGTCTCTGTTACGGAACATTGAAATGAGGACCAAACAG
ATTCAACCTTTGGAGCTAAACCTGGCAGAACTACAGGATCTGCTGTGTCAGGCCAAGGTATTAGAAAGGGAGTTAAAGGATCTGACCACC
TTGGTCAGTCAGGAGCTGGAGTGTGTGAATCAGATTATCATCAGCCAGCCTCAAGAAGTTCCTGCTCAACTGTTGAAGGCTCTAGAGAAA
GATGCCAAGAATCTTCAGAAGTCTCTCAGCTCTGTGAGTGACACTTGGAATTCCAGGCTACTCCACTTCCAGAATGCTGTGGAAATAGAA
AAGACTAAAGTGTTAAATCAGCACACACAGCTAGAAGGCCGACTTCAAGATCTGAGAGCCTGGGTTGGCAATAAAAATCTTATTCTGAAC
AGCAAGGGATCTAACAGTGAAATAGATGTTGACAGCCTGAACCTCTGCCTCCAACAGTATGAGGATTTGAAACAGCCCATGGCTGAAAGG
AAAGCTCAGCTGGATGCTCTTGCTTTTGATATTCAGTTCTTTATCTCAGAACATGCCCAGGACTTGTCCCCTCAGCAGAATCGACAGATG
CTGAGGCTTCTGAATGAACTGCAGAGGTCCTTCCAGGACATTTTGGAACAGACTGCCGCTCAGGTGGATGCCTTGCAGGGCCATCTTCAA
CAAATGGAGCAGGAAGCCCTGGTGAAGACCCTGCAGAAACAACAAAATACCTGTCACCAGCAACTGGAGGATCTTTGCAGTTGGGTAGGA
CAGGCAGAAAGAGCACTGGCAGGCCACCAAGGCAGAACCACCCAGCAGGATCTCTCTGCTTTGCAGAAGAACCAAAGTGACTTGAAGGAT
TTACAGGATGACATTCAGAATCGTGCCACCTCATTTGCCACTGTTGTCAAGGACATTGAGGGGTTCATGGAAGAGAATCAGACCAAGCTG
AGCCCACGTGAGTTGACAGCTCTTCGGGAAAAGCTTCATCAGGCTAAGGAGCAATATGAGGCGCTCCAGGAAGAGACACGTGTGGCCCAG
AAGGAACTGGAGGAAGCAGTGACCTCCGCCTTACAGCAGGAGACTGAAAAGAGTAAAGCAGCAAAGGAACTGGCAGAGAACAAGAAGAAG
ATCGATGCTCTCCTGGATTGGGTAACTTCAGTAGGATCATCTGGTGGACAGCTGCTGACCAACCTTCCAGGAATGGAGCAGCTCTCGGGA
GCTAGCTTGGAGAAAGGAGCCTTGGACACCACTGATGGTTACATGGGGGTGAATCAAGCCCCAGAGAAACTGGACAAGCAATGTGAGATG
ATGAAGGCCCGTCACCAAGAATTGCTGTCCCAGCAGCAAAATTTCATTCTGGCCACCCAGTCAGCTCAGGCCTTCTTGGATCAGCATGGC
CACAATCTCACACCTGAGGAGCAACAGATGCTGCAACAGAAGCTGGGAGAGCTAAAGGAACAATACTCTACTTCCCTGGCCCAATCAGAG
GCAGAACTGAAGCAGGTGCAGACACTTCAGGATGAGTTGCAGAAATTTCTGCAGGATCATAAAGAGTTTGAAAGCTGGTTGGAACGATCC
GAGAAAGAGCTGGAGAACATGCATAAGGGAGGCAGCAGCCCCGAGACCCTTCCCTCCCTGCTAAAGCGGCAAGGAAGCTTCTCAGAGGAT
GTCATTTCCCACAAAGGAGACTTGAGATTTGTGACTATCTCAGGACAGAAAGTCTTGGACATGGAAAACAGTTTTAAGGAAGGCAAAGAA
CCATCAGAAATTGGAAACTTAGTAAAGGACAAGTTGAAGGATGCAACAGAAAGATACACTGCTCTCCACTCAAAGTGTACACGATTAGGA
TCTCACCTGAATATGCTGTTAGGCCAGTATCATCAATTCCAAAACAGTGCTGACAGCCTGCAGGCCTGGATGCAGGCTTGTGAGGCCAAC
GTGGAGAAGCTCCTCTCAGATACTGTTGCCTCTGACCCTGGAGTTCTCCAGGAGCAGCTTGCAACAACAAAGCAGTTGCAGGAGGAATTG
GCTGAGCACCAAGTACCTGTGGAAAAACTCCAAAAAGTAGCTCGTGACATAATGGAAATTGAAGGGGAGCCAGCCCCAGACCACAGGCAT
GTTCAAGAAACTACAGATTCCATACTCAGCCACTTCCAAAGCCTCTCCTATAGCCTGGCTGAGCGATCTTCTCTGCTGCAGAAAGCAATT
GCCCAATCTCAGAGTGTCCAGGAAAGCCTGGAGAGCCTGTTGCAGTCTATTGGGGAAGTTGAACAAAACCTGGAAGGGAAGCAGGTGTCA
TCACTCTCATCAGGAGTCATCCAGGAAGCCTTAGCCACAAATATGAAATTGAAGCAGGACATTGCTCGGCAAAAGAGCAGCTTGGAGGCC
ACCCGTGAGATGGTGACCCGATTCATGGAGACAGCAGACAGTACTACAGCAGCAGTGCTGCAGGGCAAACTGGCAGAGGTGAGCCAGCGG
TTCGAACAGCTCTGTCTACAGCAGCAAGAAAAGGAGAGCTCCCTAAAGAAGCTTCTACCCCAGGCAGAGATGTTTGAACACCTCTCTGGT
AAGCTGCAGCAGTTCATGGAAAACAAAAGTCGGATGCTGGCCTCTGGAAATCAGCCAGATCAAGATATTACACATTTCTTCCAACAGATC
CAGGAGCTCAATTTGGAAATGGAAGACCAACAGGAGAACCTAGATACTCTTGAGCACCTGGTCACTGAACTGAGCTCTTGTGGCTTTGCG
CTGGACTTGTGCCAGCATCAGGACAGGGTACAGAATCTAAGAAAAGACTTCACAGAGCTACAGAAGACAGTTAAAGAGAGAGAGAAAGAT
GCATCATCTTGCCAGGAACAGTTGGATGAATTCCGGAAGCTGGTCAGGACCTTCCAGAAATGGTTGAAAGAAACTGAAGGGAGTATTCCA
CCTACGGAAACTTCTATGAGTGCTAAAGAGTTAGAAAAGCAGATTGAACACCTGAAGAGTCTACTAGATGACTGGGCAAGTAAGGGAACT
CTGGTGGAAGAAATCAATTGCAAAGGTACTTCTTTAGAAAATCTCATCATGGAAATCACAGCACCTGATTCCCAAGGCAAGACAGGTTCC
ATACTGCCCTCTGTAGGAAGCTCTGTAGGCAGTGTAAACGGATACCACACCTGCAAAGATCTGACGGAGATCCAGTGTGACATGTCAGAT
GTAAACTTGAAGTATGAGAAACTAGGGGGAGTACTTCATGAACGCCAGGAAAGCCTTCAGGCTATCCTCAACAGAATGGAGGAGGTTCAC
AAGGAGGCAAACTCTGTGCTGCAGTGGCTGGAATCAAAAGAGGAAGTCCTGAAATCCATGGATGCCATGTCATCTCCAACCAAGACAGAA
ACAGTGAAAGCCCAAGCTGAATCTAACAAGGCCTTCCTGGCTGAGTTGGAACAGAATTCTCCAAAAATTCAAAAAGTAAAGGAAGCCCTG
GCTGGATTACTGGTGACATATCCCAACTCACAGGAAGCAGAAAATTGGAAGAAAATTCAGGAAGAACTCAATTCCCGATGGGAAAGGGCC
ACTGAGGTTACTGTGGCTCGGCAAAGGCAGCTAGAGGAATCTGCAAGTCATCTGGCCTGCTTCCAGGCTGCAGAATCCCAGCTCCGGCCG
TGGCTGATGGAGAAAGAACTGATGATGGGAGTGCTGGGGCCCCTGTCTATTGACCCCAACATGTTGAATGCACAAAAGCAACAGGTCCAG
TTTATGCTAAAGGAATTTGAAGCACGCAGGCAACAGCATGAGCAACTGAATGAGGCAGCTCAGGGCATCCTAACAGGCCCTGGAGATGTC
TCTCTGTCCACCAGCCAAGTACAGAAAGAACTCCAGAGCATCAATCAGAAATGGGTTGAGCTGACTGACAAACTCAACTCCCGTTCCAGC
CAAATTGACCAAGCTATTGTTAAGAGCACCCAGTACCAGGAACTGCTCCAGGACTTATCAGAGAAGGTGAGGGCAGTTGGACAACGGCTG
AGTGTCCAGTCAGCTATCAGCACCCAACCAGAGGCTGTAAAGCAGCAATTGGAAGAGACCAGTGAAATTCGATCTGACTTGGAGCAGTTA
GACCACGAGGTTAAGGAGGCTCAGACACTGTGCGATGAACTCTCAGTGCTCATTGGTGAGCAGTACCTCAAGGATGAACTGAAGAAGCGT
TTGGAGACAGTTGCCCTGCCTCTCCAAGGTTTAGAAGACCTTGCAGCCGATCGCATTAACAGACTCCAGGCAGCTCTTGCCAGCACCCAG
CAGTTCCAGCAAATGTTTGATGAGTTGAGGACCTGGTTGGATGATAAACAAAGCCAGCAAGCAAAAAACTGCCCAATTTCTGCAAAATTG
GAGCGGCTACAGTCTCAGCTACAGGAGAATGAAGAGTTTCAGAAAAGTCTTAATCAACACAGTGGCTCCTATGAGGTGATTGTGGCTGAA
GGGGAATCTCTACTTCTTTCTGTACCTCCTGGAGAAGAGAAAAGGACTCTACAAAACCAGTTGGTTGAGCTCAAAAACCATTGGGAAGAG
CTTAGTAAAAAAACTGCAGACAGACAATCCAGGCTCAAGGATTGTATGCAGAAAGCTCAGAAATATCAGTGGCATGTGGAAGACCTTGTG
CCATGGATAGAAGATTGTAAAGCTAAGATGTCTGAGTTGCGAGTCACTCTGGATCCAGTGCAGCTAGAGTCCAGTCTCCTAAGATCAAAG
GCTATGCTGAATGAGGTGGAGAAGCGCCGCTCCCTGCTGGAAATATTGAATAGTGCTGCTGACATTCTGATCAATTCTTCAGAAGCAGAT
GAGGATGGAATCCGGGATGAGAAGGCTGGGATCAACCAGAACATGGATGCTGTTACAGAAGAGCTGCAGGCCAAAACAGGGTCACTCGAA
GAAATGACTCAGAGGCTCAGGGAGTTCCAGGAAAGCTTTAAGAATATTGAAAAGAAGGTTGAAGGAGCCAAACACCAACTTGAGATCTTT
GATGCTCTGGGTTCTCAAGCCTGTAGCAACAAGAACCTGGAGAAGCTAAGAGCTCAACAGGAAGTGCTGCAGGCCCTAGAGCCTCAGGTA
GACTATCTGAGGAACTTTACTCAGGGTCTGGTAGAAGATGCCCCAGATGGATCTGATGCTTCTCAACTTCTCCACCAAGCTGAGGTCGCC
CAGCAAGAGTTCCTCGAAGTTAAGCAAAGAGTGAACAGTGGTTGTGTGATGATGGAAAACAAGCTGGAGGGGATTGGCCAGTTTCACTGC
CGGGTCCGAGAGATGTTCTCTCAATTGGCAGACCTGGATGATGAGCTAGATGGCATGGGTGCTATTGGCAGAGACACTGATAGCCTCCAG
TCCCAAATCGAGGATGTCCGGCTATTCCTTAACAAAATTCACGTCCTCAAATTAGACATAGAGGCCTCTGAAGCAGAGTGTCGACATATG
CTAGAAGAAGAGGGGACTCTGGATTTGTTAGGTCTCAAAAGGGAGCTAGAAGCCCTGAACAAACAGTGTGGCAAACTGACAGAGAGGGGG
AAAGCTCGTCAGGAACAGCTGGAACTGACACTAGGCCGTGTAGAGGACTTCTACAGGAAATTGAAAGGACTCAATGACGCGACCACAGCA
GCAGAGGAGGCAGAGGCCCTCCAGTGGGTAGTGGGGACCGAAGTGGAAATCATCAACCAACAATTAGCAGATTTTAAAATGTTTCAGAAA
GAACAAGTGGATCCTCTTCAGATGAAATTGCAGCAGGTGAATGGACTTGGCCAGGGATTAATTCAGAGTGCAGGAAAAGACTGTGATGTA
CAGGGTTTAGAACATGACATGGAAGAGATCAATGCTCGATGGAATACATTGAATAAAAAGGTCGCACAAAGAATTGCACAGCTACAGGAA
GCTTTGTTGCATTGTGGGAAGTTTCAAGATGCCTTGGAGCCATTGCTCAGCTGGTTGGCAGATACCGAGGAGCTCATAGCCAATCAGAAA
CCTCCATCTGCTGAGTATAAAGTGGTGAAAGCACAGATCCAAGAACAGAAGTTGCTCCAGCGGCTCCTAGATGATCGAAAGGCCACAGTA
GACATGCTTCAAGCAGAAGGAGGCAGAATAGCCCAGTCAGCAGAGCTGGCTGATAGAGAGAAAATCACTGGACAGCTGGAGAGTCTTGAA
AGTAGATGGACTGAACTACTCAGTAAGGCAGCAGCCAGGCAAAAACAGCTGGAAGACATCCTGGTTCTGGCCAAACAGTTCCATGAGACA
GCTGAGCCTATTTCTGACTTCTTATCTGTCACAGAGAAAAAGCTTGCTAACTCAGAACCTGTTGGCACTCAGACTGCCAAAATACAGCAG
CAGATCATTCGGCACAAGGCTTTAAATGAAGAAATTGTTAATAGAAAGAAGAATGTAGATCAAGCTATTAAAAATGGTCAGGCTCTTCTA
AAACAAACCACAGGTGAGGAGGTGTTACTTATCCAGGAAAAACTAGATGGTATAAAGACTCGTTACGCAGACATCACAGTTACTAGCTCC
AAGGCCCTCAGAACTTTAGAGCAAGCCCGGCAGCTGGCCACCAAGTTCCAGTCTACTTATGAGGAACTGACCGGGTGGCTGAGGGAGGTG
GAGGAGGAGCTGGCAACCAGTGGAGGACAGTCTCCCACAGGGGAACAGATACCCCAGTTTCAGCAGAGACAGAAGGAATTAAAGAAGGAG
GTCATGGAGCACAGGCTGGTGTTGGACACAGTGAATGAGGTGAGCCGTGCTCTCTTAGAGCTGGTGCCCTGGAGAGCCAGAGAAGGGCTG
GATAAACTTGTGTCCGATGCTAACGAGCAGTACAAACTAGTCAGTGACACTATTGGACAAAGGGTGGATGAAATTGATGCTGCTATTCAG
AGATCACAACAGGACTTGATTAGAGACCAAGGATTTCGTGGTGATGGAGGATCAACCACAGGTTTGTCTGCTACCCCCCCTGCCTCATTA
CCTGGCTCACTAACTAACGTGAAAGCCTTACAGAAATCTCCAGGACCTCAGCGAGAAAGGAAGTCATCTTCATCCTCAGAAGACAGGAAT
CGAATGAAAACACTTGGTAGACGGGACTCGAGTGATGATTGGGAGATTCCTGATGGGCAGATTACAGTGGGACAAAGAATTGGATCTGGA
TCATTTGGAACAGTCTACAAGGGAAAGTGGCATGGTGATGTGGCAGTGAAAATGTTGAATGTGACAGCACCTACACCTCAGCAGTTACAA
GCCTTCAAAAATGAAGTAGGAGTACTCAGGAAAACACGACATGTGAATATCCTACTCTTCATGGGCTATTCCACAAAGCCACAACTGGCT
ATTGTTACCCAGTGGTGTGAGGGCTCCAGCTTGTATCACCATCTCCATATCATTGAGACCAAATTTGAGATGATCAAACTTATAGATATT
GCACGACAGACTGCACAGGGCATGGATTACTTACACGCCAAGTCAATCATCCACAGAGACCTCAAGAGTAATAATATATTTCTTCATGAA
GACCTCACAGTAAAAATAGGTGATTTTGGTCTAGCTACAGTGAAATCTCGATGGAGTGGGTCCCATCAGTTTGAACAGTTGTCTGGATCC
ATTTTGTGGATGGCACCAGAAGTCATCAGAATGCAAGATAAAAATCCATACAGCTTTCAGTCAGATGTATATGCATTTGGAATTGTTCTG
TATGAATTGATGACTGGACAGTTACCTTATTCAAACATCAACAACAGGGACCAGATAATTTTTATGGTGGGACGAGGATACCTGTCTCCA
GATCTCAGTAAGGTACGGAGTAACTGTCCAAAAGCCATGAAGAGATTAATGGCAGAGTGCCTCAAAAAGAAAAGAGATGAGAGACCACTC
TTTCCCCAAATTCTCGCCTCTATTGAGCTGCTGGCCCGCTCATTGCCAAAAATTCACCGCAGTGCATCAGAACCCTCCTTGAATCGGGCT
GGTTTCCAAACAGAGGATTTTAGTCTATATGCTTGTGCTTCTCCAAAAACACCCATCCAGGCAGGGGGATATGGTGCGTTTCCTGTCCAC
TGAAACAAATGAGTGAGAGAGTTCAGGAGAGTAGCAACAAAAGGAAAATAAATGAACATATGTTTGCTTATATGTTAAATTGAATAAAAT

>50588_50588_4_MACF1-BRAF_MACF1_chr1_39896580_ENST00000372915_BRAF_chr7_140487384_ENST00000288602_length(amino acids)=6088AA_BP=5702
MLTFTPFSFRSLLPGLPGPPAAAPAWAMSSSDEETLSERSCRSERSCRSERSYRSERSGSLSPCPPGDTLPWNLPLHEQKKRKSQDSVLD
PAERAVVRVADERDRVQKKTFTKWVNKHLMKVRKHINDLYEDLRDGHNLISLLEVLSGIKLPREKGRMRFHRLQNVQIALDFLKQRQVKL
VNIRNDDITDGNPKLTLGLIWTIILHFQISDIYISGESGDMSAKEKLLLWTQKVTAGYTGIKCTNFSSCWSDGKMFNALIHRYRPDLVDM
ERVQIQSNRENLEQAFEVAERLGVTRLLDAEDVDVPSPDEKSVITYVSSIYDAFPKVPEGGEGISATEVDSRWQEYQSRVDSLIPWIKQH
TILMSDKTFPQNPVELKALYNQYIHFKETEILAKEREKGRIEELYKLLEVWIEFGRIKLPQGYHPNDVEEEWGKLIIEMLEREKSLRPAV
ERLELLLQIANKIQNGALNCEEKLTLAKNTLQADAAHLESGQPVQCESDVIMYIQECEGLIRQLQVDLQILRDENYYQLEELAFRVMRLQ
DELVTLRLECTNLYRKGHFTSLELVPPSTLTTTHLKAEPLTKATHSSSTSWFRKPMTRAELVAISSSEDEGNLRFVYELLSWVEEMQMKL
ERAEWGNDLPSVELQLETQQHIHTSVEELGSSVKEARLYEGKMSQNFHTSYAETLGKLETQYCKLKETSSFRMRHLQSLHKFVSRATAEL
IWLNEKEEEELAYDWSDNNSNISAKRNYFSELTMELEEKQDVFRSLQDTAELLSLENHPAKQTVEAYSAAVQSQLQWMKQLCLCVEQHVK
ENTAYFQFFSDARELESFLRNLQDSIKRKYSCDHNTSLSRLEDLLQDSMDEKEQLIQSKSSVASLVGRSKTIVQLKPRSPDHVLKNTISV
KAVCDYRQIEITICKNDECVLEDNSQRTKWKVISPTGNEAMVPSVCFLIPPPNKDAIEMASRVEQSYQKVMALWHQLHVNTKSLISWNYL
RKDLDLVQTWNLEKLRSSAPGECHQIMKNLQAHYEDFLQDSRDSVLFSVADRLRLEEEVEACKARFQHLMKSMENEDKEETVAKMYISEL
KNIRLRLEEYEQRVVKRIQSLASSRTDRDAWQDNALRIAEQEHTQEDLQQLRSDLDAVSMKCDSFLHQSPSSSSVPTLRSELNLLVEKMD
HVYGLSTVYLNKLKTVDVIVRSIQDAELLVKGYEIKLSQEEVVLADLSALEAHWSTLRHWLSDVKDKNSVFSVLDEEIAKAKVVAEQMSR
LTPERNLDLERYQEKGSQLQERWHRVIAQLEIRQSELESIQEVLGDYRACHGTLIKWIEETTAQQEMMKPGQAEDSRVLSEQLSQQTALF
AEIERNQTKLDQCQKFSQQYSTIVKDYELQLMTYKAFVESQQKSPGKRRRMLSSSDAITQEFMDLRTRYTALVTLTTQHVKYISDALRRL
EEEEKVVEEEKQEHVEKVKELLGWVSTLARNTQGKATSSETKESTDIEKAILEQQVLSEELTTKKEQVSEAIKTSQIFLAKHGHKLSEKE
KKQISEQLNALNKAYHDLCDGSANQLQQLQSQLAHQTEQKECRAVAGVIDLGTVEIFPIFKAMQKGLLDQDTGLVLLESQVIMSGLIAPE
TGENLSLEEGIARNLINPQMYQQLRELQDALALISRLTESRGPLSVVEAIEKRIISETVGLKILEAHLATGGFSLSPSENCINLEEAFHQ
GLISAWLHSVLESYLRTSKNLIDPNTAEKIGLLDLMQRCIVHQESGFKLLPVKQLAGGMVSLKSGRKVSIFRAVQEGLIDRQVTVRLLEA
QLFAGGIVDPRTGHRLTVEEAVRHNLIDQDMACAILIRQLQTGGIIDTVTGQRLTIDEAVSNDLVAAKIALVILESLWSFMGLLWPESGE
ILPITDALEQGIVSTELAHKILSNRQHIKALFLPATTEILSWKKAIESGILDRDLANNLKSICIPDVMPHMQLADSAEQNINPGAAVLPC
SKSHPKATASQSENLLFQLMTHSYINVQNGQRLLLLDKELMETLTSRDEYQTSPPKVVEIGHQRQKTPEGLQESANVKISGTFSSGWTVR
LPEFQFSSQNKEYPDREDCTTEKGKKTTVETEDSSVENPEQDLFVEQKERNPNIDALKVINKVKLEVQRQLIGTQREDQTAVSVRENASR
GHLLTIPPAEAEGVPLVVDKDVFSVETPKKEHQPLRNTSFTCQNEQAHTLETEYIHDETGGSHIKPQSKKLQVQVKKTLGIKLELKSETD
GNVHPLDKKEMLKKTFLAKDDHKESQEAQNIAGGSMMMSEKTDEEDSGREIFLSCSHPLELLEEATLNVLSAQLLDGGIFHEQTGQKLLL
NEAISRGIVPSHTAVKLMEKLNMFQGFFDSQTCESLTTEEVINEGLMDEKLLHNVLMADKAISGVLDPRTQTLCSVKDAVTVGLLDKETA
TRILERQVVTGGIIDLKRGKKVSVTLASTLGLVDVADQPELINLEKASKGRDAEKTVRERLISLQMETTGLIDPDSKAPLTVVQSIDRGL
LEREEAVRLLTKQVVDGGIIHHISGMRLSVDNAFRHGLIGEDLAEKLKRVENLNIHQIFNPETKENISLPKAIKLDLITSDLKREIQEVQ
AFTGNFVDLISGQRLTLAEAKKEGLLTNEAVLSPGMMHGIVDPENCRIVPYSELVKKCKIDIESGQRYLEVIPFSDIKDGVSDKVLTLSQ
AIQLGKVDFASTLKVLEAQANTGGIIDTATGKRLTLASALEEKLVDENMVRIIASHQVLNGGIVDIFSDQRVTLVEAIEKRLISPELANM
IQIDSSEFSDHRAQIEKQEGIEVCALQNEFLGKDMLIACNQTAEMSCNKVEESERLFQVENQSAQEKVKVRVSDGEQAKKSREISLKEFG
CKDQRKPRMSSDAKEFISIINPHNLKGKSLGQVSLTHPYSECDFKLKEVARNNMGNDTNEEQEKAVTKIEIISHMKQSTSCLDSEEIREN
QGEVILEVQETYCETSGKLPSEQVLQQPMNARVKSKREKREVIVEESIRTCKPAFLSEEKLYQETAIRDEHDSHIKSQPREMTSSEKGKE
ADTEMGFSITFKIEESSSQVVPQGISVKHLDALTLFSSKQANEGKVNNLSLCLTLKPEENLSREIACGAQSEPFPCMTPRPEGLHYQESD
GKAQVTGPSQISKTDKSFQGTTRQETNYQDSWVTSKTKETKHQISSSNECKEKSYQEVSFDPARGLKLEEITVSRPDSKEVRYLEFSDRK
DLHHQGSKSDDKLCGTLKSEIATQELTGEKFLEMANPNVAGLEAGSIEDIVTQRGSRVLGSFLPEKLFKGVSQKENTGQQNAIISPTVLE
TSEEKTVSLTVCSAVKTEKTPQEKLRESPGSEQTPFMTAPEGKGNGGVNPEPFRATQNVFTRQLCLEHDEKLVSYLSLLRNIEMRTKQIQ
PLELNLAELQDLLCQAKVLERELKDLTTLVSQELECVNQIIISQPQEVPAQLLKALEKDAKNLQKSLSSVSDTWNSRLLHFQNAVEIEKT
KVLNQHTQLEGRLQDLRAWVGNKNLILNSKGSNSEIDVDSLNLCLQQYEDLKQPMAERKAQLDALAFDIQFFISEHAQDLSPQQNRQMLR
LLNELQRSFQDILEQTAAQVDALQGHLQQMEQEALVKTLQKQQNTCHQQLEDLCSWVGQAERALAGHQGRTTQQDLSALQKNQSDLKDLQ
DDIQNRATSFATVVKDIEGFMEENQTKLSPRELTALREKLHQAKEQYEALQEETRVAQKELEEAVTSALQQETEKSKAAKELAENKKKID
ALLDWVTSVGSSGGQLLTNLPGMEQLSGASLEKGALDTTDGYMGVNQAPEKLDKQCEMMKARHQELLSQQQNFILATQSAQAFLDQHGHN
LTPEEQQMLQQKLGELKEQYSTSLAQSEAELKQVQTLQDELQKFLQDHKEFESWLERSEKELENMHKGGSSPETLPSLLKRQGSFSEDVI
SHKGDLRFVTISGQKVLDMENSFKEGKEPSEIGNLVKDKLKDATERYTALHSKCTRLGSHLNMLLGQYHQFQNSADSLQAWMQACEANVE
KLLSDTVASDPGVLQEQLATTKQLQEELAEHQVPVEKLQKVARDIMEIEGEPAPDHRHVQETTDSILSHFQSLSYSLAERSSLLQKAIAQ
SQSVQESLESLLQSIGEVEQNLEGKQVSSLSSGVIQEALATNMKLKQDIARQKSSLEATREMVTRFMETADSTTAAVLQGKLAEVSQRFE
QLCLQQQEKESSLKKLLPQAEMFEHLSGKLQQFMENKSRMLASGNQPDQDITHFFQQIQELNLEMEDQQENLDTLEHLVTELSSCGFALD
LCQHQDRVQNLRKDFTELQKTVKEREKDASSCQEQLDEFRKLVRTFQKWLKETEGSIPPTETSMSAKELEKQIEHLKSLLDDWASKGTLV
EEINCKGTSLENLIMEITAPDSQGKTGSILPSVGSSVGSVNGYHTCKDLTEIQCDMSDVNLKYEKLGGVLHERQESLQAILNRMEEVHKE
ANSVLQWLESKEEVLKSMDAMSSPTKTETVKAQAESNKAFLAELEQNSPKIQKVKEALAGLLVTYPNSQEAENWKKIQEELNSRWERATE
VTVARQRQLEESASHLACFQAAESQLRPWLMEKELMMGVLGPLSIDPNMLNAQKQQVQFMLKEFEARRQQHEQLNEAAQGILTGPGDVSL
STSQVQKELQSINQKWVELTDKLNSRSSQIDQAIVKSTQYQELLQDLSEKVRAVGQRLSVQSAISTQPEAVKQQLEETSEIRSDLEQLDH
EVKEAQTLCDELSVLIGEQYLKDELKKRLETVALPLQGLEDLAADRINRLQAALASTQQFQQMFDELRTWLDDKQSQQAKNCPISAKLER
LQSQLQENEEFQKSLNQHSGSYEVIVAEGESLLLSVPPGEEKRTLQNQLVELKNHWEELSKKTADRQSRLKDCMQKAQKYQWHVEDLVPW
IEDCKAKMSELRVTLDPVQLESSLLRSKAMLNEVEKRRSLLEILNSAADILINSSEADEDGIRDEKAGINQNMDAVTEELQAKTGSLEEM
TQRLREFQESFKNIEKKVEGAKHQLEIFDALGSQACSNKNLEKLRAQQEVLQALEPQVDYLRNFTQGLVEDAPDGSDASQLLHQAEVAQQ
EFLEVKQRVNSGCVMMENKLEGIGQFHCRVREMFSQLADLDDELDGMGAIGRDTDSLQSQIEDVRLFLNKIHVLKLDIEASEAECRHMLE
EEGTLDLLGLKRELEALNKQCGKLTERGKARQEQLELTLGRVEDFYRKLKGLNDATTAAEEAEALQWVVGTEVEIINQQLADFKMFQKEQ
VDPLQMKLQQVNGLGQGLIQSAGKDCDVQGLEHDMEEINARWNTLNKKVAQRIAQLQEALLHCGKFQDALEPLLSWLADTEELIANQKPP
SAEYKVVKAQIQEQKLLQRLLDDRKATVDMLQAEGGRIAQSAELADREKITGQLESLESRWTELLSKAAARQKQLEDILVLAKQFHETAE
PISDFLSVTEKKLANSEPVGTQTAKIQQQIIRHKALNEEIVNRKKNVDQAIKNGQALLKQTTGEEVLLIQEKLDGIKTRYADITVTSSKA
LRTLEQARQLATKFQSTYEELTGWLREVEEELATSGGQSPTGEQIPQFQQRQKELKKEVMEHRLVLDTVNEVSRALLELVPWRAREGLDK
LVSDANEQYKLVSDTIGQRVDEIDAAIQRSQQDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRM
KTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIV
TQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSIL
WMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFP

--------------------------------------------------------------
>50588_50588_5_MACF1-BRAF_MACF1_chr1_39896580_ENST00000539005_BRAF_chr7_140487384_ENST00000288602_length(transcript)=12092nt_BP=10813nt
ATCACTTCTCCCTGGGCTCCCAGGCCCTCCTGCAGCAGCCCCCGCCTGGGCCATGTCTTCCTCAGATGAAGAGACGCTCAGTGAGCGGTC
ATGTCGGAGTGAGCGGTCTTGTCGGAGTGAGCGATCTTACAGGAGCGAGCGGTCGGGGAGCCTGTCTCCCTGTCCCCCAGGGGACACCTT
GCCCTGGAACCTGCCACTGCATGAGCAGAAAAAGCGGAAAAGCCAGGATTCGGTGCTGGACCCTGCAGAGCGTGCTGTGGTCAGAGTCGC
TGATGAACGGGACCGGGTTCAGAAGAAAACGTTCACCAAGTGGGTCAACAAGCACTTAATGAAGGTCCGCAAGCACATCAATGATCTTTA
TGAAGATCTGCGGGATGGCCATAACCTGATCTCTCTGTTGGAGGTCCTCTCAGGCATCAAACTGCCCCGGGAGAAGGGCAGGATGCGTTT
TCATAGGCTGCAGAATGTGCAGATTGCCCTGGACTTCCTAAAGCAGCGACAGGTGAAACTAGTGAATATTCGCAATGATGACATCACAGA
TGGCAACCCCAAGTTGACCCTGGGTCTGATCTGGACCATTATTTTGCATTTCCAGATCTCTGACATCTACATTAGTGGAGAATCAGGGGA
TATGTCAGCCAAGGAGAAACTACTCCTGTGGACCCAGAAGGTGACAGCTGGTTACACAGGAATCAAATGCACCAACTTTTCCTCCTGCTG
GAGTGATGGGAAGATGTTCAATGCACTCATTCACCGATACCGACCCGATCTAGTAGACATGGAGAGGGTGCAAATCCAAAGTAACCGAGA
GAATCTGGAACAGGCTTTTGAAGTGGCAGAAAGACTGGGGGTCACTCGCCTGCTGGATGCAGAAGATGTGGATGTGCCATCTCCAGATGA
AAAGTCTGTAATCACTTATGTGTCTTCGATTTATGATGCCTTCCCTAAAGTTCCTGAGGGTGGAGAAGGGATCAGTGCTACGGAAGTGGA
CTCCAGGTGGCAAGAATACCAAAGCCGAGTGGACTCCCTCATTCCCTGGATCAAACAGCATACAATACTGATGTCAGATAAAACTTTTCC
CCAAAACCCTGTTGAACTAAAGGCACTTTATAACCAATATATACACTTCAAAGAAACAGAAATTCTGGCCAAGGAGAGAGAAAAAGGAAG
AATTGAGGAATTATATAAATTACTAGAGGTGTGGATTGAATTTGGCCGAATTAAACTGCCTCAAGGTTATCACCCTAATGATGTGGAAGA
AGAGTGGGGAAAGCTCATCATAGAGATGCTGGAACGAGAGAAATCACTTCGGCCGGCTGTGGAGAGGCTGGAATTGCTGCTACAGATTGC
AAACAAAATCCAGAATGGTGCTTTGAACTGTGAAGAAAAACTGACACTAGCTAAGAATACACTGCAGGCTGATGCTGCTCACCTGGAATC
AGGACAACCGGTACAATGTGAGTCAGATGTCATTATGTACATTCAGGAGTGTGAAGGTCTCATCAGGCAGCTGCAGGTGGATCTCCAGAT
CCTGCGGGATGAGAATTACTACCAGCTAGAAGAGCTGGCTTTTAGGGTCATGCGTCTTCAGGATGAGCTGGTCACCTTGCGTCTAGAGTG
TACAAACCTGTACCGGAAGGGTCATTTCACTTCACTTGAATTGGTTCCACCCTCTACTTTAACCACCACTCATCTGAAAGCAGAACCCTT
AACCAAGGCAACCCATTCTTCTTCTACCTCCTGGTTCCGAAAGCCTATGACTCGGGCTGAACTTGTGGCCATCAGCTCCTCTGAAGATGA
AGGCAATCTCCGATTTGTGTATGAACTACTGTCTTGGGTAGAAGAGATGCAGATGAAACTGGAGCGAGCAGAGTGGGGCAATGACCTGCC
TAGTGTGGAGTTGCAGCTAGAAACACAGCAGCACATCCATACGAGTGTAGAAGAGCTGGGCTCAAGTGTCAAGGAGGCCAGGTTGTATGA
GGGAAAGATGTCCCAGAATTTCCATACCAGCTATGCTGAAACTCTTGGAAAGCTGGAGACACAGTATTGTAAATTGAAGGAAACTTCTAG
CTTCCGGATGAGGCACCTTCAGAGCCTGCATAAATTTGTTTCCAGAGCTACAGCTGAGTTGATCTGGTTGAATGAGAAGGAGGAGGAGGA
ACTAGCATATGACTGGAGTGACAACAATTCCAATATCTCAGCCAAGAGAAATTACTTCTCTGAGTTGACAATGGAACTGGAGGAGAAACA
GGATGTGTTTCGTTCTCTACAAGATACAGCAGAACTACTTTCACTTGAGAACCACCCAGCCAAGCAGACAGTGGAGGCTTACAGTGCTGC
TGTCCAGTCCCAGTTGCAGTGGATGAAGCAGCTGTGCCTGTGTGTTGAGCAGCATGTGAAAGAGAATACTGCTTATTTTCAGTTCTTCAG
TGATGCACGAGAGCTGGAGTCATTCTTGAGGAACCTCCAAGATTCCATTAAACGAAAATATTCCTGTGACCACAACACCAGCTTATCCCG
CCTTGAAGACCTGCTCCAGGACTCCATGGATGAAAAGGAGCAGCTTATACAGTCCAAGAGTTCCGTTGCCAGTCTCGTTGGGAGATCAAA
AACCATCGTTCAGCTAAAACCACGCAGTCCAGACCATGTGTTAAAGAACACCATTTCTGTCAAGGCTGTCTGTGACTACAGGCAGATCGA
GATTACTATTTGCAAAAATGATGAATGTGTGCTAGAAGATAATTCTCAGCGGACCAAATGGAAAGTGATCAGCCCCACAGGGAACGAGGC
AATGGTGCCGTCAGTCTGCTTCCTCATCCCCCCACCCAATAAGGATGCCATTGAGATGGCCAGCAGGGTCGAACAATCTTATCAGAAGGT
TATGGCCCTTTGGCATCAGCTGCATGTTAACACCAAAAGCCTTATCTCTTGGAACTATCTGCGTAAAGACCTTGACCTTGTACAGACCTG
GAACCTAGAAAAGCTTCGATCCTCAGCACCAGGGGAGTGCCATCAGATTATGAAGAACCTTCAGGCCCACTATGAAGACTTTCTGCAGGA
TAGTCGTGACTCTGTGCTGTTCTCAGTGGCTGATCGCTTGCGCTTGGAAGAGGAGGTGGAAGCTTGTAAAGCCCGCTTCCAGCACCTGAT
GAAGTCCATGGAGAATGAGGACAAAGAGGAGACTGTGGCCAAGATGTACATTTCAGAGTTGAAGAACATCCGGCTACGCCTGGAGGAGTA
TGAACAGAGGGTGGTCAAACGAATTCAGTCTCTAGCCAGCTCTAGGACTGACAGAGATGCCTGGCAGGACAATGCATTAAGGATTGCAGA
GCAAGAGCACACCCAGGAGGATTTACAGCAATTGAGGTCAGACTTGGATGCAGTTTCTATGAAATGTGACAGCTTTCTCCATCAGTCTCC
ATCTAGTTCAAGTGTCCCAACTCTGCGCTCAGAACTGAATCTGCTGGTGGAGAAGATGGACCATGTCTATGGTCTCTCTACTGTATATCT
GAATAAGTTAAAGACAGTTGATGTTATAGTACGTAGCATACAGGATGCTGAACTCTTGGTCAAAGGTTATGAGATTAAGCTGAGTCAAGA
AGAAGTAGTACTGGCAGATCTCTCAGCTCTGGAGGCCCATTGGTCGACATTACGGCACTGGCTTAGTGATGTGAAGGACAAGAATTCAGT
GTTTTCAGTCCTGGATGAGGAAATTGCCAAGGCCAAGGTAGTGGCAGAGCAGATGAGTCGTCTGACACCAGAGCGAAATCTGGATTTGGA
GCGCTATCAGGAAAAAGGCTCCCAGCTGCAGGAGCGTTGGCACCGAGTCATTGCCCAGCTCGAGATTCGCCAATCTGAGCTAGAAAGTAT
CCAGGAAGTTCTGGGAGATTACCGAGCCTGCCATGGAACTCTCATCAAGTGGATTGAGGAAACCACTGCCCAGCAGGAAATGATGAAGCC
AGGCCAGGCAGAGGATAGCAGAGTGCTTTCGGAGCAGCTCAGCCAGCAGACGGCCCTATTTGCAGAAATTGAGAGAAATCAGACAAAACT
GGATCAATGTCAAAAATTTTCCCAGCAGTACTCTACTATTGTAAAGGACTATGAATTGCAACTGATGACATACAAGGCCTTTGTGGAATC
GCAGCAGAAATCCCCTGGCAAGCGCCGTCGCATGCTTTCCTCTTCAGATGCCATCACTCAAGAGTTCATGGACTTAAGGACTCGCTACAC
GGCATTGGTGACTTTAACAACTCAGCACGTGAAATACATCAGTGATGCACTCCGGCGTCTGGAGGAGGAGGAGAAAGTGGTAGAAGAGGA
GAAACAAGAACATGTGGAGAAGGTTAAAGAACTTTTGGGCTGGGTGTCTACCCTAGCGAGGAATACACAAGGAAAAGCTACCTCATCCGA
GACCAAAGAATCAACAGACATTGAAAAAGCTATTTTGGAACAGCAGGTTCTGTCAGAAGAGCTGACAACAAAGAAAGAACAAGTCTCTGA
AGCTATTAAAACATCACAGATCTTCTTGGCCAAGCATGGTCATAAGCTCTCAGAAAAAGAGAAGAAACAAATATCTGAGCAATTGAATGC
CCTAAACAAGGCTTACCATGACCTTTGTGATGGTTCTGCAAATCAGCTTCAGCAGCTTCAGAGCCAGTTGGCTCACCAGACAGAACAAAA
GACCCTGCAGAAACAACAAAATACCTGTCACCAGCAACTGGAGGATCTTTGCAGTTGGGTAGGACAGGCAGAAAGAGCACTGGCAGGCCA
CCAAGGCAGAACCACCCAGCAGGATCTCTCTGCTTTGCAGAAGAACCAAAGTGACTTGAAGGATTTACAGGATGACATTCAGAATCGTGC
CACCTCATTTGCCACTGTTGTCAAGGACATTGAGGGGTTCATGGAAGAGAATCAGACCAAGCTGAGCCCACGTGAGTTGACAGCTCTTCG
GGAAAAGCTTCATCAGGCTAAGGAGCAATATGAGGCGCTCCAGGAAGAGACACGTGTGGCCCAGAAGGAACTGGAGGAAGCAGTGACCTC
CGCCTTACAGCAGGAGACTGAAAAGAGTAAAGCAGCAAAGGAACTGGCAGAGAACAAGAAGAAGATCGATGCTCTCCTGGATTGGGTAAC
TTCAGTAGGATCATCTGGTGGACAGCTGCTGACCAACCTTCCAGGAATGGAGCAGCTCTCGGGAGCTAGCTTGGAGAAAGGAGCCTTGGA
CACCACTGATGGTTACATGGGGGTGAATCAAGCCCCAGAGAAACTGGACAAGCAATGTGAGATGATGAAGGCCCGTCACCAAGAATTGCT
GTCCCAGCAGCAAAATTTCATTCTGGCCACCCAGTCAGCTCAGGCCTTCTTGGATCAGCATGGCCACAATCTCACACCTGAGGAGCAACA
GATGCTGCAACAGAAGCTGGGAGAGCTAAAGGAACAATACTCTACTTCCCTGGCCCAATCAGAGGCAGAACTGAAGCAGGTGCAGACACT
TCAGGATGAGTTGCAGAAATTTCTGCAGGATCATAAAGAGTTTGAAAGCTGGTTGGAACGATCCGAGAAAGAGCTGGAGAACATGCATAA
GGGAGGCAGCAGCCCCGAGACCCTTCCCTCCCTGCTAAAGCGGCAAGGAAGCTTCTCAGAGGATGTCATTTCCCACAAAGGAGACTTGAG
ATTTGTGACTATCTCAGGACAGAAAGTCTTGGACATGGAAAACAGTTTTAAGGAAGGCAAAGAACCATCAGAAATTGGAAACTTAGTAAA
GGACAAGTTGAAGGATGCAACAGAAAGATACACTGCTCTCCACTCAAAGTGTACACGATTAGGATCTCACCTGAATATGCTGTTAGGCCA
GTATCATCAATTCCAAAACAGTGCTGACAGCCTGCAGGCCTGGATGCAGGCTTGTGAGGCCAACGTGGAGAAGCTCCTCTCAGATACTGT
TGCCTCTGACCCTGGAGTTCTCCAGGAGCAGCTTGCAACAACAAAGCAGTTGCAGGAGGAATTGGCTGAGCACCAAGTACCTGTGGAAAA
ACTCCAAAAAGTAGCTCGTGACATAATGGAAATTGAAGGGGAGCCAGCCCCAGACCACAGGCATGTTCAAGAAACTACAGATTCCATACT
CAGCCACTTCCAAAGCCTCTCCTATAGCCTGGCTGAGCGATCTTCTCTGCTGCAGAAAGCAATTGCCCAATCTCAGAGTGTCCAGGAAAG
CCTGGAGAGCCTGTTGCAGTCTATTGGGGAAGTTGAACAAAACCTGGAAGGGAAGCAGGTGTCATCACTCTCATCAGGAGTCATCCAGGA
AGCCTTAGCCACAAATATGAAATTGAAGCAGGACATTGCTCGGCAAAAGAGCAGCTTGGAGGCCACCCGTGAGATGGTGACCCGATTCAT
GGAGACAGCAGACAGTACTACAGCAGCAGTGCTGCAGGGCAAACTGGCAGAGGTGAGCCAGCGGTTCGAACAGCTCTGTCTACAGCAGCA
AGAAAAGGAGAGCTCCCTAAAGAAGCTTCTACCCCAGGCAGAGATGTTTGAACACCTCTCTGGTAAGCTGCAGCAGTTCATGGAAAACAA
AAGTCGGATGCTGGCCTCTGGAAATCAGCCAGATCAAGATATTACACATTTCTTCCAACAGATCCAGGAGCTCAATTTGGAAATGGAAGA
CCAACAGGAGAACCTAGATACTCTTGAGCACCTGGTCACTGAACTGAGCTCTTGTGGCTTTGCGCTGGACTTGTGCCAGCATCAGGACAG
GGTACAGAATCTAAGAAAAGACTTCACAGAGCTACAGAAGACAGTTAAAGAGAGAGAGAAAGATGCATCATCTTGCCAGGAACAGTTGGA
TGAATTCCGGAAGCTGGTCAGGACCTTCCAGAAATGGTTGAAAGAAACTGAAGGGAGTATTCCACCTACGGAAACTTCTATGAGTGCTAA
AGAGTTAGAAAAGCAGATTGAACACCTGAAGAGTCTACTAGATGACTGGGCAAGTAAGGGAACTCTGGTGGAAGAAATCAATTGCAAAGG
TACTTCTTTAGAAAATCTCATCATGGAAATCACAGCACCTGATTCCCAAGGCAAGACAGATCTGACGGAGATCCAGTGTGACATGTCAGA
TGTAAACTTGAAGTATGAGAAACTAGGGGGAGTACTTCATGAACGCCAGGAAAGCCTTCAGGCTATCCTCAACAGAATGGAGGAGGTTCA
CAAGGAGGCAAACTCTGTGCTGCAGTGGCTGGAATCAAAAGAGGAAGTCCTGAAATCCATGGATGCCATGTCATCTCCAACCAAGACAGA
AACAGTGAAAGCCCAAGCTGAATCTAACAAGGCCTTCCTGGCTGAGTTGGAACAGAATTCTCCAAAAATTCAAAAAGTAAAGGAAGCCCT
GGCTGGATTACTGGTGACATATCCCAACTCACAGGAAGCAGAAAATTGGAAGAAAATTCAGGAAGAACTCAATTCCCGATGGGAAAGGGC
CACTGAGGTTACTGTGGCTCGGCAAAGGCAGCTAGAGGAATCTGCAAGTCATCTGGCCTGCTTCCAGGCTGCAGAATCCCAGCTCCGGCC
GTGGCTGATGGAGAAAGAACTGATGATGGGAGTGCTGGGGCCCCTGTCTATTGACCCCAACATGTTGAATGCACAAAAGCAACAGGTCCA
GTTTATGCTAAAGGAATTTGAAGCACGCAGGCAACAGCATGAGCAACTGAATGAGGCAGCTCAGGGCATCCTAACAGGCCCTGGAGATGT
CTCTCTGTCCACCAGCCAAGTACAGAAAGAACTCCAGAGCATCAATCAGAAATGGGTTGAGCTGACTGACAAACTCAACTCCCGTTCCAG
CCAAATTGACCAAGCTATTGTTAAGAGCACCCAGTACCAGGAACTGCTCCAGGACTTATCAGAGAAGGTGAGGGCAGTTGGACAACGGCT
GAGTGTCCAGTCAGCTATCAGCACCCAACCAGAGGCTGTAAAGCAGCAATTGGAAGAGACCAGTGAAATTCGATCTGACTTGGAGCAGTT
AGACCACGAGGTTAAGGAGGCTCAGACACTGTGCGATGAACTCTCAGTGCTCATTGGTGAGCAGTACCTCAAGGATGAACTGAAGAAGCG
TTTGGAGACAGTTGCCCTGCCTCTCCAAGGTTTAGAAGACCTTGCAGCCGATCGCATTAACAGACTCCAGGCAGCTCTTGCCAGCACCCA
GCAGTTCCAGCAAATGTTTGATGAGTTGAGGACCTGGTTGGATGATAAACAAAGCCAGCAAGCAAAAAACTGCCCAATTTCTGCAAAATT
GGAGCGGCTACAGTCTCAGCTACAGGAGAATGAAGAGTTTCAGAAAAGTCTTAATCAACACAGTGGCTCCTATGAGGTGATTGTGGCTGA
AGGGGAATCTCTACTTCTTTCTGTACCTCCTGGAGAAGAGAAAAGGACTCTACAAAACCAGTTGGTTGAGCTCAAAAACCATTGGGAAGA
GCTTAGTAAAAAAACTGCAGACAGACAATCCAGGCTCAAGGATTGTATGCAGAAAGCTCAGAAATATCAGTGGCATGTGGAAGACCTTGT
GCCATGGATAGAAGATTGTAAAGCTAAGATGTCTGAGTTGCGAGTCACTCTGGATCCAGTGCAGCTAGAGTCCAGTCTCCTAAGATCAAA
GGCTATGCTGAATGAGGTGGAGAAGCGCCGCTCCCTGCTGGAAATATTGAATAGTGCTGCTGACATTCTGATCAATTCTTCAGAAGCAGA
TGAGGATGGAATCCGGGATGAGAAGGCTGGGATCAACCAGAACATGGATGCTGTTACAGAAGAGCTGCAGGCCAAAACAGGGTCACTCGA
AGAAATGACTCAGAGGCTCAGGGAGTTCCAGGAAAGCTTTAAGAATATTGAAAAGAAGGTTGAAGGAGCCAAACACCAACTTGAGATCTT
TGATGCTCTGGGTTCTCAAGCCTGTAGCAACAAGAACCTGGAGAAGCTAAGAGCTCAACAGGAAGTGCTGCAGGCCCTAGAGCCTCAGGT
AGACTATCTGAGGAACTTTACTCAGGGTCTGGTAGAAGATGCCCCAGATGGATCTGATGCTTCTCAACTTCTCCACCAAGCTGAGGTCGC
CCAGCAAGAGTTCCTCGAAGTTAAGCAAAGAGTGAACAGTGGTTGTGTGATGATGGAAAACAAGCTGGAGGGGATTGGCCAGTTTCACTG
CCGGGTCCGAGAGATGTTCTCTCAATTGGCAGACCTGGATGATGAGCTAGATGGCATGGGTGCTATTGGCAGAGACACTGATAGCCTCCA
GTCCCAAATCGAGGATGTCCGGCTATTCCTTAACAAAATTCACGTCCTCAAATTAGACATAGAGGCCTCTGAAGCAGAGTGTCGACATAT
GCTAGAAGAAGAGGGGACTCTGGATTTGTTAGGTCTCAAAAGGGAGCTAGAAGCCCTGAACAAACAGTGTGGCAAACTGACAGAGAGGGG
GAAAGCTCGTCAGGAACAGCTGGAACTGACACTAGGCCGTGTAGAGGACTTCTACAGGAAATTGAAAGGACTCAATGACGCGACCACAGC
AGCAGAGGAGGCAGAGGCCCTCCAGTGGGTAGTGGGGACCGAAGTGGAAATCATCAACCAACAATTAGCAGATTTTAAAATGTTTCAGAA
AGAACAAGTGGATCCTCTTCAGATGAAATTGCAGCAGGTGAATGGACTTGGCCAGGGATTAATTCAGAGTGCAGGAAAAGACTGTGATGT
ACAGGGTTTAGAACATGACATGGAAGAGATCAATGCTCGATGGAATACATTGAATAAAAAGGTCGCACAAAGAATTGCACAGCTACAGGA
AGCTTTGTTGCATTGTGGGAAGTTTCAAGATGCCTTGGAGCCATTGCTCAGCTGGTTGGCAGATACCGAGGAGCTCATAGCCAATCAGAA
ACCTCCATCTGCTGAGTATAAAGTGGTGAAAGCACAGATCCAAGAACAGAAGTTGCTCCAGCGGCTCCTAGATGATCGAAAGGCCACAGT
AGACATGCTTCAAGCAGAAGGAGGCAGAATAGCCCAGTCAGCAGAGCTGGCTGATAGAGAGAAAATCACTGGACAGCTGGAGAGTCTTGA
AAGTAGATGGACTGAACTACTCAGTAAGGCAGCAGCCAGGCAAAAACAGCTGGAAGACATCCTGGTTCTGGCCAAACAGTTCCATGAGAC
AGCTGAGCCTATTTCTGACTTCTTATCTGTCACAGAGAAAAAGCTTGCTAACTCAGAACCTGTTGGCACTCAGACTGCCAAAATACAGCA
GCAGATCATTCGGCACAAGGCTTTAAATGAAGAAATTGTTAATAGAAAGAAGAATGTAGATCAAGCTATTAAAAATGGTCAGGCTCTTCT
AAAACAAACCACAGGTGAGGAGGTGTTACTTATCCAGGAAAAACTAGATGGTATAAAGACTCGTTACGCAGACATCACAGTTACTAGCTC
CAAGGCCCTCAGAACTTTAGAGCAAGCCCGGCAGCTGGCCACCAAGTTCCAGTCTACTTATGAGGAACTGACCGGGTGGCTGAGGGAGGT
GGAGGAGGAGCTGGCAACCAGTGGAGGACAGTCTCCCACAGGGGAACAGATACCCCAGTTTCAGCAGAGACAGAAGGAATTAAAGAAGGA
GGTCATGGAGCACAGGCTGGTGTTGGACACAGTGAATGAGGTGAGCCGTGCTCTCTTAGAGCTGGTGCCCTGGAGAGCCAGAGAAGGGCT
GGATAAACTTGTGTCCGATGCTAACGAGCAGTACAAACTAGTCAGTGACACTATTGGACAAAGGGTGGATGAAATTGATGCTGCTATTCA
GAGATCACAACAGGACTTGATTAGAGACCAAGGATTTCGTGGTGATGGAGGATCAACCACAGGTTTGTCTGCTACCCCCCCTGCCTCATT
ACCTGGCTCACTAACTAACGTGAAAGCCTTACAGAAATCTCCAGGACCTCAGCGAGAAAGGAAGTCATCTTCATCCTCAGAAGACAGGAA
TCGAATGAAAACACTTGGTAGACGGGACTCGAGTGATGATTGGGAGATTCCTGATGGGCAGATTACAGTGGGACAAAGAATTGGATCTGG
ATCATTTGGAACAGTCTACAAGGGAAAGTGGCATGGTGATGTGGCAGTGAAAATGTTGAATGTGACAGCACCTACACCTCAGCAGTTACA
AGCCTTCAAAAATGAAGTAGGAGTACTCAGGAAAACACGACATGTGAATATCCTACTCTTCATGGGCTATTCCACAAAGCCACAACTGGC
TATTGTTACCCAGTGGTGTGAGGGCTCCAGCTTGTATCACCATCTCCATATCATTGAGACCAAATTTGAGATGATCAAACTTATAGATAT
TGCACGACAGACTGCACAGGGCATGGATTACTTACACGCCAAGTCAATCATCCACAGAGACCTCAAGAGTAATAATATATTTCTTCATGA
AGACCTCACAGTAAAAATAGGTGATTTTGGTCTAGCTACAGTGAAATCTCGATGGAGTGGGTCCCATCAGTTTGAACAGTTGTCTGGATC
CATTTTGTGGATGGCACCAGAAGTCATCAGAATGCAAGATAAAAATCCATACAGCTTTCAGTCAGATGTATATGCATTTGGAATTGTTCT
GTATGAATTGATGACTGGACAGTTACCTTATTCAAACATCAACAACAGGGACCAGATAATTTTTATGGTGGGACGAGGATACCTGTCTCC
AGATCTCAGTAAGGTACGGAGTAACTGTCCAAAAGCCATGAAGAGATTAATGGCAGAGTGCCTCAAAAAGAAAAGAGATGAGAGACCACT
CTTTCCCCAAATTCTCGCCTCTATTGAGCTGCTGGCCCGCTCATTGCCAAAAATTCACCGCAGTGCATCAGAACCCTCCTTGAATCGGGC
TGGTTTCCAAACAGAGGATTTTAGTCTATATGCTTGTGCTTCTCCAAAAACACCCATCCAGGCAGGGGGATATGGTGCGTTTCCTGTCCA
CTGAAACAAATGAGTGAGAGAGTTCAGGAGAGTAGCAACAAAAGGAAAATAAATGAACATATGTTTGCTTATATGTTAAATTGAATAAAA

>50588_50588_5_MACF1-BRAF_MACF1_chr1_39896580_ENST00000539005_BRAF_chr7_140487384_ENST00000288602_length(amino acids)=3973AA_BP=3587
MSSSDEETLSERSCRSERSCRSERSYRSERSGSLSPCPPGDTLPWNLPLHEQKKRKSQDSVLDPAERAVVRVADERDRVQKKTFTKWVNK
HLMKVRKHINDLYEDLRDGHNLISLLEVLSGIKLPREKGRMRFHRLQNVQIALDFLKQRQVKLVNIRNDDITDGNPKLTLGLIWTIILHF
QISDIYISGESGDMSAKEKLLLWTQKVTAGYTGIKCTNFSSCWSDGKMFNALIHRYRPDLVDMERVQIQSNRENLEQAFEVAERLGVTRL
LDAEDVDVPSPDEKSVITYVSSIYDAFPKVPEGGEGISATEVDSRWQEYQSRVDSLIPWIKQHTILMSDKTFPQNPVELKALYNQYIHFK
ETEILAKEREKGRIEELYKLLEVWIEFGRIKLPQGYHPNDVEEEWGKLIIEMLEREKSLRPAVERLELLLQIANKIQNGALNCEEKLTLA
KNTLQADAAHLESGQPVQCESDVIMYIQECEGLIRQLQVDLQILRDENYYQLEELAFRVMRLQDELVTLRLECTNLYRKGHFTSLELVPP
STLTTTHLKAEPLTKATHSSSTSWFRKPMTRAELVAISSSEDEGNLRFVYELLSWVEEMQMKLERAEWGNDLPSVELQLETQQHIHTSVE
ELGSSVKEARLYEGKMSQNFHTSYAETLGKLETQYCKLKETSSFRMRHLQSLHKFVSRATAELIWLNEKEEEELAYDWSDNNSNISAKRN
YFSELTMELEEKQDVFRSLQDTAELLSLENHPAKQTVEAYSAAVQSQLQWMKQLCLCVEQHVKENTAYFQFFSDARELESFLRNLQDSIK
RKYSCDHNTSLSRLEDLLQDSMDEKEQLIQSKSSVASLVGRSKTIVQLKPRSPDHVLKNTISVKAVCDYRQIEITICKNDECVLEDNSQR
TKWKVISPTGNEAMVPSVCFLIPPPNKDAIEMASRVEQSYQKVMALWHQLHVNTKSLISWNYLRKDLDLVQTWNLEKLRSSAPGECHQIM
KNLQAHYEDFLQDSRDSVLFSVADRLRLEEEVEACKARFQHLMKSMENEDKEETVAKMYISELKNIRLRLEEYEQRVVKRIQSLASSRTD
RDAWQDNALRIAEQEHTQEDLQQLRSDLDAVSMKCDSFLHQSPSSSSVPTLRSELNLLVEKMDHVYGLSTVYLNKLKTVDVIVRSIQDAE
LLVKGYEIKLSQEEVVLADLSALEAHWSTLRHWLSDVKDKNSVFSVLDEEIAKAKVVAEQMSRLTPERNLDLERYQEKGSQLQERWHRVI
AQLEIRQSELESIQEVLGDYRACHGTLIKWIEETTAQQEMMKPGQAEDSRVLSEQLSQQTALFAEIERNQTKLDQCQKFSQQYSTIVKDY
ELQLMTYKAFVESQQKSPGKRRRMLSSSDAITQEFMDLRTRYTALVTLTTQHVKYISDALRRLEEEEKVVEEEKQEHVEKVKELLGWVST
LARNTQGKATSSETKESTDIEKAILEQQVLSEELTTKKEQVSEAIKTSQIFLAKHGHKLSEKEKKQISEQLNALNKAYHDLCDGSANQLQ
QLQSQLAHQTEQKTLQKQQNTCHQQLEDLCSWVGQAERALAGHQGRTTQQDLSALQKNQSDLKDLQDDIQNRATSFATVVKDIEGFMEEN
QTKLSPRELTALREKLHQAKEQYEALQEETRVAQKELEEAVTSALQQETEKSKAAKELAENKKKIDALLDWVTSVGSSGGQLLTNLPGME
QLSGASLEKGALDTTDGYMGVNQAPEKLDKQCEMMKARHQELLSQQQNFILATQSAQAFLDQHGHNLTPEEQQMLQQKLGELKEQYSTSL
AQSEAELKQVQTLQDELQKFLQDHKEFESWLERSEKELENMHKGGSSPETLPSLLKRQGSFSEDVISHKGDLRFVTISGQKVLDMENSFK
EGKEPSEIGNLVKDKLKDATERYTALHSKCTRLGSHLNMLLGQYHQFQNSADSLQAWMQACEANVEKLLSDTVASDPGVLQEQLATTKQL
QEELAEHQVPVEKLQKVARDIMEIEGEPAPDHRHVQETTDSILSHFQSLSYSLAERSSLLQKAIAQSQSVQESLESLLQSIGEVEQNLEG
KQVSSLSSGVIQEALATNMKLKQDIARQKSSLEATREMVTRFMETADSTTAAVLQGKLAEVSQRFEQLCLQQQEKESSLKKLLPQAEMFE
HLSGKLQQFMENKSRMLASGNQPDQDITHFFQQIQELNLEMEDQQENLDTLEHLVTELSSCGFALDLCQHQDRVQNLRKDFTELQKTVKE
REKDASSCQEQLDEFRKLVRTFQKWLKETEGSIPPTETSMSAKELEKQIEHLKSLLDDWASKGTLVEEINCKGTSLENLIMEITAPDSQG
KTDLTEIQCDMSDVNLKYEKLGGVLHERQESLQAILNRMEEVHKEANSVLQWLESKEEVLKSMDAMSSPTKTETVKAQAESNKAFLAELE
QNSPKIQKVKEALAGLLVTYPNSQEAENWKKIQEELNSRWERATEVTVARQRQLEESASHLACFQAAESQLRPWLMEKELMMGVLGPLSI
DPNMLNAQKQQVQFMLKEFEARRQQHEQLNEAAQGILTGPGDVSLSTSQVQKELQSINQKWVELTDKLNSRSSQIDQAIVKSTQYQELLQ
DLSEKVRAVGQRLSVQSAISTQPEAVKQQLEETSEIRSDLEQLDHEVKEAQTLCDELSVLIGEQYLKDELKKRLETVALPLQGLEDLAAD
RINRLQAALASTQQFQQMFDELRTWLDDKQSQQAKNCPISAKLERLQSQLQENEEFQKSLNQHSGSYEVIVAEGESLLLSVPPGEEKRTL
QNQLVELKNHWEELSKKTADRQSRLKDCMQKAQKYQWHVEDLVPWIEDCKAKMSELRVTLDPVQLESSLLRSKAMLNEVEKRRSLLEILN
SAADILINSSEADEDGIRDEKAGINQNMDAVTEELQAKTGSLEEMTQRLREFQESFKNIEKKVEGAKHQLEIFDALGSQACSNKNLEKLR
AQQEVLQALEPQVDYLRNFTQGLVEDAPDGSDASQLLHQAEVAQQEFLEVKQRVNSGCVMMENKLEGIGQFHCRVREMFSQLADLDDELD
GMGAIGRDTDSLQSQIEDVRLFLNKIHVLKLDIEASEAECRHMLEEEGTLDLLGLKRELEALNKQCGKLTERGKARQEQLELTLGRVEDF
YRKLKGLNDATTAAEEAEALQWVVGTEVEIINQQLADFKMFQKEQVDPLQMKLQQVNGLGQGLIQSAGKDCDVQGLEHDMEEINARWNTL
NKKVAQRIAQLQEALLHCGKFQDALEPLLSWLADTEELIANQKPPSAEYKVVKAQIQEQKLLQRLLDDRKATVDMLQAEGGRIAQSAELA
DREKITGQLESLESRWTELLSKAAARQKQLEDILVLAKQFHETAEPISDFLSVTEKKLANSEPVGTQTAKIQQQIIRHKALNEEIVNRKK
NVDQAIKNGQALLKQTTGEEVLLIQEKLDGIKTRYADITVTSSKALRTLEQARQLATKFQSTYEELTGWLREVEEELATSGGQSPTGEQI
PQFQQRQKELKKEVMEHRLVLDTVNEVSRALLELVPWRAREGLDKLVSDANEQYKLVSDTIGQRVDEIDAAIQRSQQDLIRDQGFRGDGG
STTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVK
MLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSII
HRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRD
QIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKT

--------------------------------------------------------------
>50588_50588_6_MACF1-BRAF_MACF1_chr1_39896580_ENST00000545844_BRAF_chr7_140487384_ENST00000288602_length(transcript)=12538nt_BP=11259nt
GATGAAGAAACTGAGTCTCAGAGAGGTGAAGTGACTTGCCCAAGATCACAGCAATTATCACTTCTCCCTGGGCTCCCAGGCCCTCCTGCA
GCAGCCCCCGCCTGGGCCATGTCTTCCTCAGATGAAGAGACGCTCAGTGAGCGGTCATGTCGGAGTGAGCGGTCTTGTCGGAGTGAGCGA
TCTTACAGGAGCGAGCGGTCGGGGAGCCTGTCTCCCTGTCCCCCAGGGGACACCTTGCCCTGGAACCTGCCACTGCATGAGCAGAAAAAG
CGGAAAAGCCAGGATTCGGTGCTGGACCCTGCAGAGCGTGCTGTGGTCAGAGTCGCTGATGAACGGGACCGGGTTCAGAAGAAAACGTTC
ACCAAGTGGGTCAACAAGCACTTAATGAAGGTCCGCAAGCACATCAATGATCTTTATGAAGATCTGCGGGATGGCCATAACCTGATCTCT
CTGTTGGAGGTCCTCTCAGGCATCAAACTGCCCCGGGAGAAGGGCAGGATGCGTTTTCATAGGCTGCAGAATGTGCAGATTGCCCTGGAC
TTCCTAAAGCAGCGACAGGTGAAACTAGTGAATATTCGCAATGATGACATCACAGATGGCAACCCCAAGTTGACCCTGGGTCTGATCTGG
ACCATTATTTTGCATTTCCAGATCTCTGACATCTACATTAGTGGAGAATCAGGGGATATGTCAGCCAAGGAGAAACTACTCCTGTGGACC
CAGAAGGTGACAGCTGGTTACACAGGAATCAAATGCACCAACTTTTCCTCCTGCTGGAGTGATGGGAAGATGTTCAATGCACTCATTCAC
CGATACCGACCCGATCTAGTAGACATGGAGAGGGTGCAAATCCAAAGTAACCGAGAGAATCTGGAACAGGCTTTTGAAGTGGCAGAAAGA
CTGGGGGTCACTCGCCTGCTGGATGCAGAAGATGTGGATGTGCCATCTCCAGATGAAAAGTCTGTAATCACTTATGTGTCTTCGATTTAT
GATGCCTTCCCTAAAGTTCCTGAGGGTGGAGAAGGGATCAGTGCTACGGAAGTGGACTCCAGGTGGCAAGAATACCAAAGCCGAGTGGAC
TCCCTCATTCCCTGGATCAAACAGCATACAATACTGATGTCAGATAAAACTTTTCCCCAAAACCCTGTTGAACTAAAGGCACTTTATAAC
CAATATATACACTTCAAAGAAACAGAAATTCTGGCCAAGGAGAGAGAAAAAGGAAGAATTGAGGAATTATATAAATTACTAGAGGTGTGG
ATTGAATTTGGCCGAATTAAACTGCCTCAAGGTTATCACCCTAATGATGTGGAAGAAGAGTGGGGAAAGCTCATCATAGAGATGCTGGAA
CGAGAGAAATCACTTCGGCCGGCTGTGGAGAGGCTGGAATTGCTGCTACAGATTGCAAACAAAATCCAGAATGGTGCTTTGAACTGTGAA
GAAAAACTGACACTAGCTAAGAATACACTGCAGGCTGATGCTGCTCACCTGGAATCAGGACAACCGGTACAATGTGAGTCAGATGTCATT
ATGTACATTCAGGAGTGTGAAGGTCTCATCAGGCAGCTGCAGGTGGATCTCCAGATCCTGCGGGATGAGAATTACTACCAGCTAGAAGAG
CTGGCTTTTAGGGTCATGCGTCTTCAGGATGAGCTGGTCACCTTGCGTCTAGAGTGTACAAACCTGTACCGGAAGGGTCATTTCACTTCA
CTTGAATTGGTTCCACCCTCTACTTTAACCACCACTCATCTGAAAGCAGAACCCTTAACCAAGGCAACCCATTCTTCTTCTACCTCCTGG
TTCCGAAAGCCTATGACTCGGGCTGAACTTGTGGCCATCAGCTCCTCTGAAGATGAAGGCAATCTCCGATTTGTGTATGAACTACTGTCT
TGGGTAGAAGAGATGCAGATGAAACTGGAGCGAGCAGAGTGGGGCAATGACCTGCCTAGTGTGGAGTTGCAGCTAGAAACACAGCAGCAC
ATCCATACGAGTGTAGAAGAGCTGGGCTCAAGTGTCAAGGAGGCCAGGTTGTATGAGGGAAAGATGTCCCAGAATTTCCATACCAGCTAT
GCTGAAACTCTTGGAAAGCTGGAGACACAGTATTGTAAATTGAAGGAAACTTCTAGCTTCCGGATGAGGCACCTTCAGAGCCTGCATAAA
TTTGTTTCCAGAGCTACAGCTGAGTTGATCTGGTTGAATGAGAAGGAGGAGGAGGAACTAGCATATGACTGGAGTGACAACAATTCCAAT
ATCTCAGCCAAGAGAAATTACTTCTCTGAGTTGACAATGGAACTGGAGGAGAAACAGGATGTGTTTCGTTCTCTACAAGATACAGCAGAA
CTACTTTCACTTGAGAACCACCCAGCCAAGCAGACAGTGGAGGCTTACAGTGCTGCTGTCCAGTCCCAGTTGCAGTGGATGAAGCAGCTG
TGCCTGTGTGTTGAGCAGCATGTGAAAGAGAATACTGCTTATTTTCAGTTCTTCAGTGATGCACGAGAGCTGGAGTCATTCTTGAGGAAC
CTCCAAGATTCCATTAAACGAAAATATTCCTGTGACCACAACACCAGCTTATCCCGCCTTGAAGACCTGCTCCAGGACTCCATGGATGAA
AAGGAGCAGCTTATACAGTCCAAGAGTTCCGTTGCCAGTCTCGTTGGGAGATCAAAAACCATCGTTCAGCTAAAACCACGCAGTCCAGAC
CATGTGTTAAAGAACACCATTTCTGTCAAGGCTGTCTGTGACTACAGGCAGATCGAGATTACTATTTGCAAAAATGATGAATGTGTGCTA
GAAGATAATTCTCAGCGGACCAAATGGAAAGTGATCAGCCCCACAGGGAACGAGGCAATGGTGCCGTCAGTCTGCTTCCTCATCCCCCCA
CCCAATAAGGATGCCATTGAGATGGCCAGCAGGGTCGAACAATCTTATCAGAAGGTTATGGCCCTTTGGCATCAGCTGCATGTTAACACC
AAAAGCCTTATCTCTTGGAACTATCTGCGTAAAGACCTTGACCTTGTACAGACCTGGAACCTAGAAAAGCTTCGATCCTCAGCACCAGGG
GAGTGCCATCAGATTATGAAGAACCTTCAGGCCCACTATGAAGACTTTCTGCAGGATAGTCGTGACTCTGTGCTGTTCTCAGTGGCTGAT
CGCTTGCGCTTGGAAGAGGAGGTGGAAGCTTGTAAAGCCCGCTTCCAGCACCTGATGAAGTCCATGGAGAATGAGGACAAAGAGGAGACT
GTGGCCAAGATGTACATTTCAGAGTTGAAGAACATCCGGCTACGCCTGGAGGAGTATGAACAGAGGGTGGTCAAACGAATTCAGTCTCTA
GCCAGCTCTAGGACTGACAGAGATGCCTGGCAGGACAATGCATTAAGGATTGCAGAGCAAGAGCACACCCAGGAGGATTTACAGCAATTG
AGGTCAGACTTGGATGCAGTTTCTATGAAATGTGACAGCTTTCTCCATCAGTCTCCATCTAGTTCAAGTGTCCCAACTCTGCGCTCAGAA
CTGAATCTGCTGGTGGAGAAGATGGACCATGTCTATGGTCTCTCTACTGTATATCTGAATAAGTTAAAGACAGTTGATGTTATAGTACGT
AGCATACAGGATGCTGAACTCTTGGTCAAAGGTTATGAGATTAAGCTGAGTCAAGAAGAAGTAGTACTGGCAGATCTCTCAGCTCTGGAG
GCCCATTGGTCGACATTACGGCACTGGCTTAGTGATGTGAAGGACAAGAATTCAGTGTTTTCAGTCCTGGATGAGGAAATTGCCAAGGCC
AAGGTAGTGGCAGAGCAGATGAGTCGTCTGACACCAGAGCGAAATCTGGATTTGGAGCGCTATCAGGAAAAAGGCTCCCAGCTGCAGGAG
CGTTGGCACCGAGTCATTGCCCAGCTCGAGATTCGCCAATCTGAGCTAGAAAGTATCCAGGAAGTTCTGGGAGATTACCGAGCCTGCCAT
GGAACTCTCATCAAGTGGATTGAGGAAACCACTGCCCAGCAGGAAATGATGAAGCCAGGCCAGGCAGAGGATAGCAGAGTGCTTTCGGAG
CAGCTCAGCCAGCAGACGGCCCTATTTGCAGAAATTGAGAGAAATCAGACAAAACTGGATCAATGTCAAAAATTTTCCCAGCAGTACTCT
ACTATTGTAAAGGACTATGAATTGCAACTGATGACATACAAGGCCTTTGTGGAATCGCAGCAGAAATCCCCTGGCAAGCGCCGTCGCATG
CTTTCCTCTTCAGATGCCATCACTCAAGAGTTCATGGACTTAAGGACTCGCTACACGGCATTGGTGACTTTAACAACTCAGCACGTGAAA
TACATCAGTGATGCACTCCGGCGTCTGGAGGAGGAGGAGAAAGTGGTAGAAGAGGAGAAACAAGAACATGTGGAGAAGGTTAAAGAACTT
TTGGGCTGGGTGTCTACCCTAGCGAGGAATACACAAGGAAAAGCTACCTCATCCGAGACCAAAGAATCAACAGACATTGAAAAAGCTATT
TTGGAACAGCAGGTTCTGTCAGAAGAGCTGACAACAAAGAAAGAACAAGTCTCTGAAGCTATTAAAACATCACAGATCTTCTTGGCCAAG
CATGGTCATAAGCTCTCAGAAAAAGAGAAGAAACAAATATCTGAGCAATTGAATGCCCTAAACAAGGCTTACCATGACCTTTGTGATGGT
TCTGCAAATCAGCTTCAGCAGCTTCAGAGCCAGTTGGCTCACCAGACAGAACAAAAGACCCTGCAGAAACAACAAAATACCTGTCACCAG
CAACTGGAGGATCTTTGCAGTTGGGTAGGACAGGCAGAAAGAGCACTGGCAGGCCACCAAGGCAGAACCACCCAGCAGGATCTCTCTGCT
TTGCAGAAGAACCAAAGTGACTTGAAGGATTTACAGGATGACATTCAGAATCGTGCCACCTCATTTGCCACTGTTGTCAAGGACATTGAG
GGGTTCATGGAAGAGAATCAGACCAAGCTGAGCCCACGTGAGTTGACAGCTCTTCGGGAAAAGCTTCATCAGGCTAAGGAGCAATATGAG
GCGCTCCAGGAAGAGACACGTGTGGCCCAGAAGGAACTGGAGGAAGCAGTGACCTCCGCCTTACAGCAGGAGACTGAAAAGAGTAAAGCA
GCAAAGGAACTGGCAGAGAACAAGAAGAAGATCGATGCTCTCCTGGATTGGGTAACTTCAGTAGGATCATCTGGTGGACAGCTGCTGACC
AACCTTCCAGGAATGGAGCAGCTCTCGGGAGCTAGCTTGGAGAAAGGAGCCTTGGACACCACTGATGGTTACATGGGGGTGAATCAAGCC
CCAGAGAAACTGGACAAGCAATGTGAGATGATGAAGGCCCGTCACCAAGAATTGCTGTCCCAGCAGCAAAATTTCATTCTGGCCACCCAG
TCAGCTCAGGCCTTCTTGGATCAGCATGGCCACAATCTCACACCTGAGGAGCAACAGATGCTGCAACAGAAGCTGGGAGAGCTAAAGGAA
CAATACTCTACTTCCCTGGCCCAATCAGAGGCAGAACTGAAGCAGGTGCAGACACTTCAGGATGAGTTGCAGAAATTTCTGCAGGATCAT
AAAGAGTTTGAAAGCTGGTTGGAACGATCCGAGAAAGAGCTGGAGAACATGCATAAGGGAGGCAGCAGCCCCGAGACCCTTCCCTCCCTG
CTAAAGCGGCAAGGAAGCTTCTCAGAGGATGTCATTTCCCACAAAGGAGACTTGAGATTTGTGACTATCTCAGGACAGAAAGTCTTGGAC
ATGGAAAACAGTTTTAAGGAAGGCAAAGAACCATCAGAAATTGGAAACTTAGTAAAGGACAAGTTGAAGGATGCAACAGAAAGATACACT
GCTCTCCACTCAAAGTGTACACGATTAGGATCTCACCTGAATATGCTGTTAGGCCAGTATCATCAATTCCAAAACAGTGCTGACAGCCTG
CAGGCCTGGATGCAGGCTTGTGAGGCCAACGTGGAGAAGCTCCTCTCAGATACTGTTGCCTCTGACCCTGGAGTTCTCCAGGAGCAGCTT
GCAACAACAAAGCAGTTGCAGGAGGAATTGGCTGAGCACCAAGTACCTGTGGAAAAACTCCAAAAAGTAGCTCGTGACATAATGGAAATT
GAAGGGGAGCCAGCCCCAGACCACAGGCATGTTCAAGAAACTACAGATTCCATACTCAGCCACTTCCAAAGCCTCTCCTATAGCCTGGCT
GAGCGATCTTCTCTGCTGCAGAAAGCAATTGCCCAATCTCAGAGTGTCCAGGAAAGCCTGGAGAGCCTGTTGCAGTCTATTGGGGAAGTT
GAACAAAACCTGGAAGGGAAGCAGGTGTCATCACTCTCATCAGGAGTCATCCAGGAAGCCTTAGCCACAAATATGAAATTGAAGCAGGAC
ATTGCTCGGCAAAAGAGCAGCTTGGAGGCCACCCGTGAGATGGTGACCCGATTCATGGAGACAGCAGACAGTACTACAGCAGCAGTGCTG
CAGGGCAAACTGGCAGAGGTGAGCCAGCGGTTCGAACAGCTCTGTCTACAGCAGCAAGAAAAGGAGAGCTCCCTAAAGAAGCTTCTACCC
CAGGCAGAGATGTTTGAACACCTCTCTGGTAAGCTGCAGCAGTTCATGGAAAACAAAAGTCGGATGCTGGCCTCTGGAAATCAGCCAGAT
CAAGATATTACACATTTCTTCCAACAGATCCAGGAGCTCAATTTGGAAATGGAAGACCAACAGGAGAACCTAGATACTCTTGAGCACCTG
GTCACTGAACTGAGCTCTTGTGGCTTTGCGCTGGACTTGTGCCAGCATCAGGACAGGGTACAGAATCTAAGAAAAGACTTCACAGAGCTA
CAGAAGACAGTTAAAGAGAGAGAGAAAGATGCATCATCTTGCCAGGAACAGTTGGATGAATTCCGGAAGCTGGTCAGGACCTTCCAGAAA
TGGTTGAAAGAAACTGAAGGGAGTATTCCACCTACGGAAACTTCTATGAGTGCTAAAGAGTTAGAAAAGCAGATTGAACACCTGAAGAGT
CTACTAGATGACTGGGCAAGTAAGGGAACTCTGGTGGAAGAAATCAATTGCAAAGGTACTTCTTTAGAAAATCTCATCATGGAAATCACA
GCACCTGATTCCCAAGGCAAGACAGGTTCCATACTGCCCTCTGTAGGAAGCTCTGTAGGCAGTGTAAACGGATACCACACCTGCAAAGAT
CTGACGGAGATCCAGTGTGACATGTCAGATGTAAACTTGAAGTATGAGAAACTAGGGGGAGTACTTCATGAACGCCAGGAAAGCCTTCAG
GCTATCCTCAACAGAATGGAGGAGGTTCACAAGGAGGCAAACTCTGTGCTGCAGTGGCTGGAATCAAAAGAGGAAGTCCTGAAATCCATG
GATGCCATGTCATCTCCAACCAAGACAGAAACAGTGAAAGCCCAAGCTGAATCTAACAAGGCCTTCCTGGCTGAGTTGGAACAGAATTCT
CCAAAAATTCAAAAAGTAAAGGAAGCCCTGGCTGGATTACTGGTGACATATCCCAACTCACAGGAAGCAGAAAATTGGAAGAAAATTCAG
GAAGAACTCAATTCCCGATGGGAAAGGGCCACTGAGGTTACTGTGGCTCGGCAAAGGCAGCTAGAGGAATCTGCAAGTCATCTGGCCTGC
TTCCAGGCTGCAGAATCCCAGCTCCGGCCGTGGCTGATGGAGAAAGAACTGATGATGGGAGTGCTGGGGCCCCTGTCTATTGACCCCAAC
ATGTTGAATGCACAAAAGCAACAGGTCCAGTTTATGCTAAAGGAATTTGAAGCACGCAGGCAACAGCATGAGCAACTGAATGAGGCAGCT
CAGGGCATCCTAACAGGCCCTGGAGATGTCTCTCTGTCCACCAGCCAAGTACAGAAAGAACTCCAGAGCATCAATCAGAAATGGGTTGAG
CTGACTGACAAACTCAACTCCCGTTCCAGCCAAATTGACCAAGCTATTGTTAAGAGCACCCAGTACCAGGAACTGCTCCAGGACTTATCA
GAGAAGGTGAGGGCAGTTGGACAACGGCTGAGTGTCCAGTCAGCTATCAGCACCCAACCAGAGGCTGTAAAGCAGCAATTGGAAGAGACC
AGTGAAATTCGATCTGACTTGGAGCAGTTAGACCACGAGGTTAAGGAGGCTCAGACACTGTGCGATGAACTCTCAGTGCTCATTGGTGAG
CAGTACCTCAAGGATGAACTGAAGAAGCGTTTGGAGACAGTTGCCCTGCCTCTCCAAGGTTTAGAAGACCTTGCAGCCGATCGCATTAAC
AGACTCCAGGCAGCTCTTGCCAGCACCCAGCAGTTCCAGCAAATGTTTGATGAGTTGAGGACCTGGTTGGATGATAAACAAAGCCAGCAA
GCAAAAAACTGCCCAATTTCTGCAAAATTGGAGCGGCTACAGTCTCAGCTACAGGAGAATGAAGAGTTTCAGAAAAGTCTTAATCAACAC
AGTGGCTCCTATGAGGTGATTGTGGCTGAAGGGGAATCTCTACTTCTTTCTGTACCTCCTGGAGAAGAGAAAAGGACTCTACAAAACCAG
TTGGTTGAGCTCAAAAACCATTGGGAAGAGCTTAGTAAAAAAACTGCAGACAGACAATCCAGGCTCAAGGATTGTATGCAGAAAGCTCAG
AAATATCAGTGGCATGTGGAAGACCTTGTGCCATGGATAGAAGATTGTAAAGCTAAGATGTCTGAGTTGCGAGTCACTCTGGATCCAGTG
CAGCTAGAGTCCAGTCTCCTAAGATCAAAGGCTATGCTGAATGAGGTGGAGAAGCGCCGCTCCCTGCTGGAAATATTGAATAGTGCTGCT
GACATTCTGATCAATTCTTCAGAAGCAGATGAGGATGGAATCCGGGATGAGAAGGCTGGGATCAACCAGAACATGGATGCTGTTACAGAA
GAGCTGCAGGCCAAAACAGGGTCACTCGAAGAAATGACTCAGAGGCTCAGGGAGTTCCAGGAAAGCTTTAAGAATATTGAAAAGAAGGTT
GAAGGAGCCAAACACCAACTTGAGATCTTTGATGCTCTGGGTTCTCAAGCCTGTAGCAACAAGAACCTGGAGAAGCTAAGAGCTCAACAG
GAAGTGCTGCAGGCCCTAGAGCCTCAGGTAGACTATCTGAGGAACTTTACTCAGGGTCTGGTAGAAGATGCCCCAGATGGATCTGATGCT
TCTCAACTTCTCCACCAAGCTGAGGTCGCCCAGCAAGAGTTCCTCGAAGTTAAGCAAAGAGTGAACAGTGGTTGTGTGATGATGGAAAAC
AAGCTGGAGGGGATTGGCCAGTTTCACTGCCGGGTCCGAGAGATGTTCTCTCAATTGGCAGACCTGGATGATGAGCTAGATGGCATGGGT
GCTATTGGCAGAGACACTGATAGCCTCCAGTCCCAAATCGAGGATGTCCGGCTATTCCTTAACAAAATTCACGTCCTCAAATTAGACATA
GAGGCCTCTGAAGCAGAGTGTCGACATATGCTAGAAGAAGAGGGGACTCTGGATTTGTTAGGTCTCAAAAGGGAGCTAGAAGCCCTGAAC
AAACAGTGTGGCAAACTGACAGAGAGGGGGAAAGCTCGTCAGGAACAGCTGGAACTGACACTAGGCCGTGTAGAGGACTTCTACAGGAAA
TTGAAAGGACTCAATGACGCGACCACAGCAGCAGAGGAGGCAGAGGCCCTCCAGTGGGTAGTGGGGACCGAAGTGGAAATCATCAACCAA
CAATTAGCAGATTTTAAAATGTTTCAGAAAGAACAAGTGGATCCTCTTCAGATGAAATTGCAGCAGGTGAATGGACTTGGCCAGGGATTA
ATTCAGAGTGCAGGAAAAGACTGTGATGTACAGGGTTTAGAACATGACATGGAAGAGATCAATGCTCGATGGAATACATTGAATAAAAAG
GTCGCACAAAGAATTGCACAGCTACAGGAAGCTTTGTTGCATTGTGGGAAGTTTCAAGATGCCTTGGAGCCATTGCTCAGCTGGTTGGCA
GATACCGAGGAGCTCATAGCCAATCAGAAACCTCCATCTGCTGAGTATAAAGTGGTGAAAGCACAGATCCAAGAACAGAAGTTGCTCCAG
CGGCTCCTAGATGATCGAAAGGCCACAGTAGACATGCTTCAAGCAGAAGGAGGCAGAATAGCCCAGTCAGCAGAGCTGGCTGATAGAGAG
AAAATCACTGGACAGCTGGAGAGTCTTGAAAGTAGATGGACTGAACTACTCAGTAAGGCAGCAGCCAGGCAAAAACAGCTGGAAGACATC
CTGGTTCTGGCCAAACAGTTCCATGAGACAGCTGAGCCTATTTCTGACTTCTTATCTGTCACAGAGAAAAAGCTTGCTAACTCAGAACCT
GTTGGCACTCAGACTGCCAAAATACAGCAGCAGATCATTCGGCACAAGGCTCTGGAAGAAGACATAGAAAACCATGCAACAGATGTGCAC
CAGGCAGTCAAAATTGGGCAGTCCCTCTCCTCCCTGACATCTCCTGCAGAACAGGGTGTGCTGTCAGAAAAGATAGACTCATTGCAGGCC
CGATACAGTGAAATTCAAGACCGCTGTTGTCGGAAGGCAGCCCTACTTGACCAAGCTCTGTCTAATGCTAGGCTGTTTGGGGAGGATGAG
GTGGAGGTGCTCAACTGGCTGGCTGAGGTTGAGGACAAGCTCAGTTCAGTGTTCGTAAAGGATTTCAAACAGGATGTCCTGCACAGGCAG
CATGCTGACCACCTGGCTTTAAATGAAGAAATTGTTAATAGAAAGAAGAATGTAGATCAAGCTATTAAAAATGGTCAGGCTCTTCTAAAA
CAAACCACAGGTGAGGAGGTGTTACTTATCCAGGAAAAACTAGATGGTATAAAGACTCGTTACGCAGACATCACAGTTACTAGCTCCAAG
GCCCTCAGAACTTTAGAGCAAGCCCGGCAGCTGGCCACCAAGTTCCAGTCTACTTATGAGGAACTGACCGGGTGGCTGAGGGAGGTGGAG
GAGGAGCTGGCAACCAGTGGAGGACAGTCTCCCACAGGGGAACAGATACCCCAGTTTCAGCAGAGACAGAAGGAATTAAAGAAGGAGGTC
ATGGAGCACAGGCTGGTGTTGGACACAGTGAATGAGGTGAGCCGTGCTCTCTTAGAGCTGGTGCCCTGGAGAGCCAGAGAAGGGCTGGAT
AAACTTGTGTCCGATGCTAACGAGCAGTACAAACTAGTCAGTGACACTATTGGACAAAGGGTGGATGAAATTGATGCTGCTATTCAGAGA
TCACAACAGGACTTGATTAGAGACCAAGGATTTCGTGGTGATGGAGGATCAACCACAGGTTTGTCTGCTACCCCCCCTGCCTCATTACCT
GGCTCACTAACTAACGTGAAAGCCTTACAGAAATCTCCAGGACCTCAGCGAGAAAGGAAGTCATCTTCATCCTCAGAAGACAGGAATCGA
ATGAAAACACTTGGTAGACGGGACTCGAGTGATGATTGGGAGATTCCTGATGGGCAGATTACAGTGGGACAAAGAATTGGATCTGGATCA
TTTGGAACAGTCTACAAGGGAAAGTGGCATGGTGATGTGGCAGTGAAAATGTTGAATGTGACAGCACCTACACCTCAGCAGTTACAAGCC
TTCAAAAATGAAGTAGGAGTACTCAGGAAAACACGACATGTGAATATCCTACTCTTCATGGGCTATTCCACAAAGCCACAACTGGCTATT
GTTACCCAGTGGTGTGAGGGCTCCAGCTTGTATCACCATCTCCATATCATTGAGACCAAATTTGAGATGATCAAACTTATAGATATTGCA
CGACAGACTGCACAGGGCATGGATTACTTACACGCCAAGTCAATCATCCACAGAGACCTCAAGAGTAATAATATATTTCTTCATGAAGAC
CTCACAGTAAAAATAGGTGATTTTGGTCTAGCTACAGTGAAATCTCGATGGAGTGGGTCCCATCAGTTTGAACAGTTGTCTGGATCCATT
TTGTGGATGGCACCAGAAGTCATCAGAATGCAAGATAAAAATCCATACAGCTTTCAGTCAGATGTATATGCATTTGGAATTGTTCTGTAT
GAATTGATGACTGGACAGTTACCTTATTCAAACATCAACAACAGGGACCAGATAATTTTTATGGTGGGACGAGGATACCTGTCTCCAGAT
CTCAGTAAGGTACGGAGTAACTGTCCAAAAGCCATGAAGAGATTAATGGCAGAGTGCCTCAAAAAGAAAAGAGATGAGAGACCACTCTTT
CCCCAAATTCTCGCCTCTATTGAGCTGCTGGCCCGCTCATTGCCAAAAATTCACCGCAGTGCATCAGAACCCTCCTTGAATCGGGCTGGT
TTCCAAACAGAGGATTTTAGTCTATATGCTTGTGCTTCTCCAAAAACACCCATCCAGGCAGGGGGATATGGTGCGTTTCCTGTCCACTGA
AACAAATGAGTGAGAGAGTTCAGGAGAGTAGCAACAAAAGGAAAATAAATGAACATATGTTTGCTTATATGTTAAATTGAATAAAATACT

>50588_50588_6_MACF1-BRAF_MACF1_chr1_39896580_ENST00000545844_BRAF_chr7_140487384_ENST00000288602_length(amino acids)=4103AA_BP=3717
MSSSDEETLSERSCRSERSCRSERSYRSERSGSLSPCPPGDTLPWNLPLHEQKKRKSQDSVLDPAERAVVRVADERDRVQKKTFTKWVNK
HLMKVRKHINDLYEDLRDGHNLISLLEVLSGIKLPREKGRMRFHRLQNVQIALDFLKQRQVKLVNIRNDDITDGNPKLTLGLIWTIILHF
QISDIYISGESGDMSAKEKLLLWTQKVTAGYTGIKCTNFSSCWSDGKMFNALIHRYRPDLVDMERVQIQSNRENLEQAFEVAERLGVTRL
LDAEDVDVPSPDEKSVITYVSSIYDAFPKVPEGGEGISATEVDSRWQEYQSRVDSLIPWIKQHTILMSDKTFPQNPVELKALYNQYIHFK
ETEILAKEREKGRIEELYKLLEVWIEFGRIKLPQGYHPNDVEEEWGKLIIEMLEREKSLRPAVERLELLLQIANKIQNGALNCEEKLTLA
KNTLQADAAHLESGQPVQCESDVIMYIQECEGLIRQLQVDLQILRDENYYQLEELAFRVMRLQDELVTLRLECTNLYRKGHFTSLELVPP
STLTTTHLKAEPLTKATHSSSTSWFRKPMTRAELVAISSSEDEGNLRFVYELLSWVEEMQMKLERAEWGNDLPSVELQLETQQHIHTSVE
ELGSSVKEARLYEGKMSQNFHTSYAETLGKLETQYCKLKETSSFRMRHLQSLHKFVSRATAELIWLNEKEEEELAYDWSDNNSNISAKRN
YFSELTMELEEKQDVFRSLQDTAELLSLENHPAKQTVEAYSAAVQSQLQWMKQLCLCVEQHVKENTAYFQFFSDARELESFLRNLQDSIK
RKYSCDHNTSLSRLEDLLQDSMDEKEQLIQSKSSVASLVGRSKTIVQLKPRSPDHVLKNTISVKAVCDYRQIEITICKNDECVLEDNSQR
TKWKVISPTGNEAMVPSVCFLIPPPNKDAIEMASRVEQSYQKVMALWHQLHVNTKSLISWNYLRKDLDLVQTWNLEKLRSSAPGECHQIM
KNLQAHYEDFLQDSRDSVLFSVADRLRLEEEVEACKARFQHLMKSMENEDKEETVAKMYISELKNIRLRLEEYEQRVVKRIQSLASSRTD
RDAWQDNALRIAEQEHTQEDLQQLRSDLDAVSMKCDSFLHQSPSSSSVPTLRSELNLLVEKMDHVYGLSTVYLNKLKTVDVIVRSIQDAE
LLVKGYEIKLSQEEVVLADLSALEAHWSTLRHWLSDVKDKNSVFSVLDEEIAKAKVVAEQMSRLTPERNLDLERYQEKGSQLQERWHRVI
AQLEIRQSELESIQEVLGDYRACHGTLIKWIEETTAQQEMMKPGQAEDSRVLSEQLSQQTALFAEIERNQTKLDQCQKFSQQYSTIVKDY
ELQLMTYKAFVESQQKSPGKRRRMLSSSDAITQEFMDLRTRYTALVTLTTQHVKYISDALRRLEEEEKVVEEEKQEHVEKVKELLGWVST
LARNTQGKATSSETKESTDIEKAILEQQVLSEELTTKKEQVSEAIKTSQIFLAKHGHKLSEKEKKQISEQLNALNKAYHDLCDGSANQLQ
QLQSQLAHQTEQKTLQKQQNTCHQQLEDLCSWVGQAERALAGHQGRTTQQDLSALQKNQSDLKDLQDDIQNRATSFATVVKDIEGFMEEN
QTKLSPRELTALREKLHQAKEQYEALQEETRVAQKELEEAVTSALQQETEKSKAAKELAENKKKIDALLDWVTSVGSSGGQLLTNLPGME
QLSGASLEKGALDTTDGYMGVNQAPEKLDKQCEMMKARHQELLSQQQNFILATQSAQAFLDQHGHNLTPEEQQMLQQKLGELKEQYSTSL
AQSEAELKQVQTLQDELQKFLQDHKEFESWLERSEKELENMHKGGSSPETLPSLLKRQGSFSEDVISHKGDLRFVTISGQKVLDMENSFK
EGKEPSEIGNLVKDKLKDATERYTALHSKCTRLGSHLNMLLGQYHQFQNSADSLQAWMQACEANVEKLLSDTVASDPGVLQEQLATTKQL
QEELAEHQVPVEKLQKVARDIMEIEGEPAPDHRHVQETTDSILSHFQSLSYSLAERSSLLQKAIAQSQSVQESLESLLQSIGEVEQNLEG
KQVSSLSSGVIQEALATNMKLKQDIARQKSSLEATREMVTRFMETADSTTAAVLQGKLAEVSQRFEQLCLQQQEKESSLKKLLPQAEMFE
HLSGKLQQFMENKSRMLASGNQPDQDITHFFQQIQELNLEMEDQQENLDTLEHLVTELSSCGFALDLCQHQDRVQNLRKDFTELQKTVKE
REKDASSCQEQLDEFRKLVRTFQKWLKETEGSIPPTETSMSAKELEKQIEHLKSLLDDWASKGTLVEEINCKGTSLENLIMEITAPDSQG
KTGSILPSVGSSVGSVNGYHTCKDLTEIQCDMSDVNLKYEKLGGVLHERQESLQAILNRMEEVHKEANSVLQWLESKEEVLKSMDAMSSP
TKTETVKAQAESNKAFLAELEQNSPKIQKVKEALAGLLVTYPNSQEAENWKKIQEELNSRWERATEVTVARQRQLEESASHLACFQAAES
QLRPWLMEKELMMGVLGPLSIDPNMLNAQKQQVQFMLKEFEARRQQHEQLNEAAQGILTGPGDVSLSTSQVQKELQSINQKWVELTDKLN
SRSSQIDQAIVKSTQYQELLQDLSEKVRAVGQRLSVQSAISTQPEAVKQQLEETSEIRSDLEQLDHEVKEAQTLCDELSVLIGEQYLKDE
LKKRLETVALPLQGLEDLAADRINRLQAALASTQQFQQMFDELRTWLDDKQSQQAKNCPISAKLERLQSQLQENEEFQKSLNQHSGSYEV
IVAEGESLLLSVPPGEEKRTLQNQLVELKNHWEELSKKTADRQSRLKDCMQKAQKYQWHVEDLVPWIEDCKAKMSELRVTLDPVQLESSL
LRSKAMLNEVEKRRSLLEILNSAADILINSSEADEDGIRDEKAGINQNMDAVTEELQAKTGSLEEMTQRLREFQESFKNIEKKVEGAKHQ
LEIFDALGSQACSNKNLEKLRAQQEVLQALEPQVDYLRNFTQGLVEDAPDGSDASQLLHQAEVAQQEFLEVKQRVNSGCVMMENKLEGIG
QFHCRVREMFSQLADLDDELDGMGAIGRDTDSLQSQIEDVRLFLNKIHVLKLDIEASEAECRHMLEEEGTLDLLGLKRELEALNKQCGKL
TERGKARQEQLELTLGRVEDFYRKLKGLNDATTAAEEAEALQWVVGTEVEIINQQLADFKMFQKEQVDPLQMKLQQVNGLGQGLIQSAGK
DCDVQGLEHDMEEINARWNTLNKKVAQRIAQLQEALLHCGKFQDALEPLLSWLADTEELIANQKPPSAEYKVVKAQIQEQKLLQRLLDDR
KATVDMLQAEGGRIAQSAELADREKITGQLESLESRWTELLSKAAARQKQLEDILVLAKQFHETAEPISDFLSVTEKKLANSEPVGTQTA
KIQQQIIRHKALEEDIENHATDVHQAVKIGQSLSSLTSPAEQGVLSEKIDSLQARYSEIQDRCCRKAALLDQALSNARLFGEDEVEVLNW
LAEVEDKLSSVFVKDFKQDVLHRQHADHLALNEEIVNRKKNVDQAIKNGQALLKQTTGEEVLLIQEKLDGIKTRYADITVTSSKALRTLE
QARQLATKFQSTYEELTGWLREVEEELATSGGQSPTGEQIPQFQQRQKELKKEVMEHRLVLDTVNEVSRALLELVPWRAREGLDKLVSDA
NEQYKLVSDTIGQRVDEIDAAIQRSQQDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGR
RDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCE
GSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPE
VIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILAS

--------------------------------------------------------------
>50588_50588_7_MACF1-BRAF_MACF1_chr1_39896580_ENST00000564288_BRAF_chr7_140487384_ENST00000288602_length(transcript)=19393nt_BP=18114nt
GGGATTACAGCCATGAACCACTGCGCCCAGCCAGACGGATTTTTTTAACCCTTGAGAAGTACCCCCTAAATGAGCAGTTTGCTCTCCTCG
CTGATCTTCATCACACCTAGATGTCAGGTCTGCTTCATGGGAGCTTGCTCTGTATGTATCCTCCCTGGACTGATGTTCAGGCTCCTTGCT
TCTCCTCCCGGGTTGTGGGTATGGAGGGTTTGCCCTCTGACAACTCCAGGGTACTTGTGGTGCTCATACATCCTCATGTACTTTGCTTTC
TCCCCGCAAGAGGTTCCCTAATGCTTCTGTGACTTTTTTCTTCTGGCTACATCCTGAAGTCTGGCCTTGCAGGCAGGCTGGGAATGGAAA
GTTAAGAGTGTGACGTCCTCTGACACCCTCCCTTCTTGTAGAAGGGTCTGAGGTTTGTTTATTTAAGCTGAGCAGAGGATGCCAAAGATA
GAGGTTTGAGTCAGCTTGACACTGGCTTAGGCGCTCCTTTTCACTCTCCTTGTTCCTTCTTCCCTTTCCCCTCCCCCGCTGGCCAGTTGT
TTCCTGGGCTTTGTCTGAGATACACTGTACAGTTTTAGTCCCAGTCTACTAGCGCCTGCTGAAAAACAGTCAGAAGTGAGATGGAGGAGA
AGCTGCCAGGAAGTTTCTGACAACACTAAGCTCCGGCCTCTGCCTCTGCTGATAGTACAGGACAACAGTAACCTCAGGAGAAAGGCATCC
AGAGGCCTGCGCTGAGCTTGTGGCTAACTCAAGGGAGGAGAAAGGACGGGCCTGGAAATGCCCCTCTTAGATTCATCTTATTTACCACCA
ACCATCTTTATTTTGACTCACGTTCTTGGAGTTGCTGGTGTTCTATACTGGAAGAGGCATGCCAGAGGTAGAGCAGATGAACGGGACCGG
GTTCAGAAGAAAACGTTCACCAAGTGGGTCAACAAGCACTTAATGAAGGTCCGCAAGCACATCAATGATCTTTATGAAGATCTGCGGGAT
GGCCATAACCTGATCTCTCTGTTGGAGGTCCTCTCAGGCATCAAACTGGAGCCAGCAGGGCTGAAGACCCTCCGTCTGGTGAGCATGCCC
TCCTGGTGCCATACAAACAACGAGGAGCAGGCGGAGGAAGATGATGATGATGTACCCCGGGAGAAGGGCAGGATGCGTTTTCATAGGCTG
CAGAATGTGCAGATTGCCCTGGACTTCCTAAAGCAGCGACAGGTGAAACTAGTGAATATTCGCAATGATGACATCACAGATGGCAACCCC
AAGTTGACCCTGGGTCTGATCTGGACCATTATTTTGCATTTCCAGATCTCTGACATCTACATTAGTGGAGAATCAGGGGATATGTCAGCC
AAGGAGAAACTACTCCTGTGGACCCAGAAGGTGACAGCTGGTTACACAGGAATCAAATGCACCAACTTTTCCTCCTGCTGGAGTGATGGG
AAGATGTTCAATGCACTCATTCACCGATACCGACCCGATCTAGTAGACATGGAGAGGGTGCAAATCCAAAGTAACCGAGAGAATCTGGAA
CAGGCTTTTGAAGTGGCAGAAAGACTGGGGGTCACTCGCCTGCTGGATGCAGAAGATGTGGATGTGCCATCTCCAGATGAAAAGTCTGTA
ATCACTTATGTGTCTTCGATTTATGATGCCTTCCCTAAAGTTCCTGAGGGTGGAGAAGGGATCAGTGCTACGGAAGTGGACTCCAGGTGG
CAAGAATACCAAAGCCGAGTGGACTCCCTCATTCCCTGGATCAAACAGCATACAATACTGATGTCAGATAAAACTTTTCCCCAAAACCCT
GTTGAACTAAAGGCACTTTATAACCAATATATACACTTCAAAGAAACAGAAATTCTGGCCAAGGAGAGAGAAAAAGGAAGAATTGAGGAA
TTATATAAATTACTAGAGGTGTGGATTGAATTTGGCCGAATTAAACTGCCTCAAGGTTATCACCCTAATGATGTGGAAGAAGAGTGGGGA
AAGCTCATCATAGAGATGCTGGAACGAGAGAAATCACTTCGGCCGGCTGTGGAGAGGCTGGAATTGCTGCTACAGATTGCAAACAAAATC
CAGAATGGTGCTTTGAACTGTGAAGAAAAACTGACACTAGCTAAGAATACACTGCAGGCTGATGCTGCTCACCTGGAATCAGGACAACCG
GTACAATGTGAGTCAGATGTCATTATGTACATTCAGGAGTGTGAAGGTCTCATCAGGCAGCTGCAGGTGGATCTCCAGATCCTGCGGGAT
GAGAATTACTACCAGCTAGAAGAGCTGGCTTTTAGGGTCATGCGTCTTCAGGATGAGCTGGTCACCTTGCGTCTAGAGTGTACAAACCTG
TACCGGAAGGGTCATTTCACTTCACTTGAATTGGTTCCACCCTCTACTTTAACCACCACTCATCTGAAAGCAGAACCCTTAACCAAGGCA
ACCCATTCTTCTTCTACCTCCTGGTTCCGAAAGCCTATGACTCGGGCTGAACTTGTGGCCATCAGCTCCTCTGAAGATGAAGGCAATCTC
CGATTTGTGTATGAACTACTGTCTTGGGTAGAAGAGATGCAGATGAAACTGGAGCGAGCAGAGTGGGGCAATGACCTGCCTAGTGTGGAG
TTGCAGCTAGAAACACAGCAGCACATCCATACGAGTGTAGAAGAGCTGGGCTCAAGTGTCAAGGAGGCCAGGTTGTATGAGGGAAAGATG
TCCCAGAATTTCCATACCAGCTATGCTGAAACTCTTGGAAAGCTGGAGACACAGTATTGTAAATTGAAGGAAACTTCTAGCTTCCGGATG
AGGCACCTTCAGAGCCTGCATAAATTTGTTTCCAGAGCTACAGCTGAGTTGATCTGGTTGAATGAGAAGGAGGAGGAGGAACTAGCATAT
GACTGGAGTGACAACAATTCCAATATCTCAGCCAAGAGAAATTACTTCTCTGAGTTGACAATGGAACTGGAGGAGAAACAGGATGTGTTT
CGTTCTCTACAAGATACAGCAGAACTACTTTCACTTGAGAACCACCCAGCCAAGCAGACAGTGGAGGCTTACAGTGCTGCTGTCCAGTCC
CAGTTGCAGTGGATGAAGCAGCTGTGCCTGTGTGTTGAGCAGCATGTGAAAGAGAATACTGCTTATTTTCAGTTCTTCAGTGATGCACGA
GAGCTGGAGTCATTCTTGAGGAACCTCCAAGATTCCATTAAACGAAAATATTCCTGTGACCACAACACCAGCTTATCCCGCCTTGAAGAC
CTGCTCCAGGACTCCATGGATGAAAAGGAGCAGCTTATACAGTCCAAGAGTTCCGTTGCCAGTCTCGTTGGGAGATCAAAAACCATCGTT
CAGCTAAAACCACGCAGTCCAGACCATGTGTTAAAGAACACCATTTCTGTCAAGGCTGTCTGTGACTACAGGCAGATCGAGATTACTATT
TGCAAAAATGATGAATGTGTGCTAGAAGATAATTCTCAGCGGACCAAATGGAAAGTGATCAGCCCCACAGGGAACGAGGCAATGGTGCCG
TCAGTCTGCTTCCTCATCCCCCCACCCAATAAGGATGCCATTGAGATGGCCAGCAGGGTCGAACAATCTTATCAGAAGGTTATGGCCCTT
TGGCATCAGCTGCATGTTAACACCAAAAGCCTTATCTCTTGGAACTATCTGCGTAAAGACCTTGACCTTGTACAGACCTGGAACCTAGAA
AAGCTTCGATCCTCAGCACCAGGGGAGTGCCATCAGATTATGAAGAACCTTCAGGCCCACTATGAAGACTTTCTGCAGGATAGTCGTGAC
TCTGTGCTGTTCTCAGTGGCTGATCGCTTGCGCTTGGAAGAGGAGGTGGAAGCTTGTAAAGCCCGCTTCCAGCACCTGATGAAGTCCATG
GAGAATGAGGACAAAGAGGAGACTGTGGCCAAGATGTACATTTCAGAGTTGAAGAACATCCGGCTACGCCTGGAGGAGTATGAACAGAGG
GTGGTCAAACGAATTCAGTCTCTAGCCAGCTCTAGGACTGACAGAGATGCCTGGCAGGACAATGCATTAAGGATTGCAGAGCAAGAGCAC
ACCCAGGAGGATTTACAGCAATTGAGGTCAGACTTGGATGCAGTTTCTATGAAATGTGACAGCTTTCTCCATCAGTCTCCATCTAGTTCA
AGTGTCCCAACTCTGCGCTCAGAACTGAATCTGCTGGTGGAGAAGATGGACCATGTCTATGGTCTCTCTACTGTATATCTGAATAAGTTA
AAGACAGTTGATGTTATAGTACGTAGCATACAGGATGCTGAACTCTTGGTCAAAGGTTATGAGATTAAGCTGAGTCAAGAAGAAGTAGTA
CTGGCAGATCTCTCAGCTCTGGAGGCCCATTGGTCGACATTACGGCACTGGCTTAGTGATGTGAAGGACAAGAATTCAGTGTTTTCAGTC
CTGGATGAGGAAATTGCCAAGGCCAAGGTAGTGGCAGAGCAGATGAGTCGTCTGACACCAGAGCGAAATCTGGATTTGGAGCGCTATCAG
GAAAAAGGCTCCCAGCTGCAGGAGCGTTGGCACCGAGTCATTGCCCAGCTCGAGATTCGCCAATCTGAGCTAGAAAGTATCCAGGAAGTT
CTGGGAGATTACCGAGCCTGCCATGGAACTCTCATCAAGTGGATTGAGGAAACCACTGCCCAGCAGGAAATGATGAAGCCAGGCCAGGCA
GAGGATAGCAGAGTGCTTTCGGAGCAGCTCAGCCAGCAGACGGCCCTATTTGCAGAAATTGAGAGAAATCAGACAAAACTGGATCAATGT
CAAAAATTTTCCCAGCAGTACTCTACTATTGTAAAGGACTATGAATTGCAACTGATGACATACAAGGCCTTTGTGGAATCGCAGCAGAAA
TCCCCTGGCAAGCGCCGTCGCATGCTTTCCTCTTCAGATGCCATCACTCAAGAGTTCATGGACTTAAGGACTCGCTACACGGCATTGGTG
ACTTTAACAACTCAGCACGTGAAATACATCAGTGATGCACTCCGGCGTCTGGAGGAGGAGGAGAAAGTGGTAGAAGAGGAGAAACAAGAA
CATGTGGAGAAGGTTAAAGAACTTTTGGGCTGGGTGTCTACCCTAGCGAGGAATACACAAGGAAAAGCTACCTCATCCGAGACCAAAGAA
TCAACAGACATTGAAAAAGCTATTTTGGAACAGCAGGTTCTGTCAGAAGAGCTGACAACAAAGAAAGAACAAGTCTCTGAAGCTATTAAA
ACATCACAGATCTTCTTGGCCAAGCATGGTCATAAGCTCTCAGAAAAAGAGAAGAAACAAATATCTGAGCAATTGAATGCCCTAAACAAG
GCTTACCATGACCTTTGTGATGGTTCTGCAAATCAGCTTCAGCAGCTTCAGAGCCAGTTGGCTCACCAGACAGAACAAAAGGAATGCAGA
GCAGTTGCTGGGGTGATTGACCTAGGCACAGTGGAGATATTTCCCATCTTCAAAGCCATGCAAAAGGGCCTCCTTGACCAAGACACAGGC
CTAGTGCTTCTGGAATCTCAGGTTATCATGTCTGGCCTCATTGCCCCTGAGACGGGTGAAAACCTCTCTTTGGAGGAGGGCATAGCCAGA
AACCTCATTAATCCCCAGATGTACCAGCAGCTCCGGGAGCTACAGGATGCCCTGGCCTTAATAAGCAGGCTTACTGAGAGCAGAGGCCCT
CTTTCTGTGGTGGAAGCAATTGAAAAGAGAATAATCAGTGAGACAGTTGGACTGAAAATCTTAGAAGCTCACCTGGCAACTGGAGGTTTC
AGTCTTTCCCCTAGTGAGAACTGTATTAACCTGGAAGAGGCTTTTCATCAAGGCCTCATTTCTGCATGGCTTCATTCAGTATTAGAGTCT
TATCTTAGAACATCCAAGAATTTGATAGACCCTAACACAGCTGAGAAAATTGGTTTGCTGGATCTGATGCAGCGATGTATTGTCCACCAG
GAATCAGGATTCAAATTACTGCCTGTCAAACAATTGGCAGGGGGGATGGTGAGCTTGAAATCAGGCCGGAAGGTTAGCATTTTCCGTGCA
GTTCAGGAAGGGCTAATAGATAGGCAGGTCACTGTCCGGTTGCTGGAAGCTCAGCTTTTTGCTGGTGGCATAGTAGATCCAAGAACAGGA
CACAGACTTACAGTGGAAGAGGCTGTAAGACATAATCTGATTGACCAAGATATGGCCTGTGCTATCCTCATAAGGCAGCTTCAGACAGGA
GGCATCATAGACACTGTCACGGGGCAAAGGCTAACAATAGATGAAGCAGTGAGCAATGATCTAGTAGCTGCTAAGATCGCCCTTGTGATT
CTGGAGTCCCTCTGGTCATTCATGGGGTTGCTGTGGCCTGAATCTGGAGAGATCCTCCCAATTACAGATGCCCTAGAACAAGGTATTGTG
TCTACTGAACTAGCACATAAAATCCTTAGTAACCGACAGCATATTAAGGCTCTGTTTCTACCAGCAACCACAGAGATTTTGTCCTGGAAG
AAAGCAATAGAAAGTGGTATCCTGGATAGAGATCTTGCCAATAACTTAAAATCGATTTGTATACCTGATGTGATGCCCCACATGCAACTA
GCAGACTCTGCAGAACAAAATATTAATCCTGGAGCAGCAGTTCTACCGTGCAGCAAGAGCCACCCTAAGGCCACAGCAAGCCAGAGTGAG
AATCTGTTGTTCCAGCTGATGACTCACAGCTATATTAATGTGCAAAATGGACAGAGGCTGCTTCTGTTAGATAAAGAGCTGATGGAGACA
CTAACATCCAGAGATGAGTATCAAACAAGTCCTCCAAAAGTGGTTGAAATTGGGCATCAAAGGCAAAAAACTCCTGAGGGATTGCAAGAA
TCAGCTAATGTGAAAATCTCAGGAACTTTCAGCAGTGGGTGGACTGTGAGGCTGCCTGAGTTCCAGTTTTCTTCTCAGAACAAAGAATAT
CCCGATCGGGAAGATTGCACTACAGAAAAAGGCAAAAAGACCACTGTAGAAACAGAAGATTCTTCTGTAGAGAACCCTGAACAGGATCTG
TTTGTAGAACAAAAAGAGAGAAATCCAAACATTGATGCTTTGAAGGTAATAAATAAAGTCAAATTAGAGGTACAAAGGCAGTTGATAGGT
ACCCAAAGGGAAGACCAAACAGCAGTGTCTGTCAGAGAAAATGCCAGCAGGGGACACCTCCTGACCATACCTCCTGCTGAGGCGGAAGGT
GTGCCGTTGGTGGTTGACAAAGATGTTTTTTCTGTTGAAACACCAAAGAAAGAACATCAACCTCTAAGAAACACTTCCTTTACATGTCAG
AATGAACAAGCACACACTCTTGAGACTGAATATATTCATGATGAAACTGGAGGATCTCACATAAAACCCCAAAGCAAAAAGTTACAAGTT
CAGGTAAAGAAAACTCTAGGTATAAAGTTAGAACTAAAGTCTGAAACTGATGGGAATGTTCATCCTCTGGACAAAAAGGAAATGTTAAAG
AAAACATTTCTGGCTAAGGATGACCATAAAGAAAGTCAAGAAGCACAGAACATCGCAGGTGGTAGTATGATGATGTCAGAAAAGACCGAT
GAGGAAGATAGTGGCAGGGAAATTTTTCTGTCATGCAGTCATCCATTAGAATTGCTTGAAGAAGCTACCTTAAATGTATTATCTGCACAG
TTACTAGATGGTGGTATCTTTCATGAACAAACAGGTCAAAAGCTCTTACTAAATGAAGCAATATCCCGAGGCATTGTGCCAAGTCACACT
GCCGTGAAGCTTATGGAGAAGCTGAACATGTTTCAGGGGTTCTTTGACTCTCAGACTTGTGAGTCTTTGACAACTGAAGAAGTCATTAAT
GAAGGTCTGATGGATGAGAAATTATTACATAATGTCCTCATGGCAGACAAAGCTATAAGTGGTGTCTTAGACCCCCGTACCCAGACACTG
TGCTCTGTAAAGGATGCAGTTACAGTTGGACTTCTTGACAAGGAAACAGCCACCAGAATTTTAGAGAGGCAGGTGGTGACTGGTGGAATT
ATTGATCTGAAACGAGGCAAAAAAGTTTCAGTAACTTTGGCCTCAACTCTTGGCTTGGTGGACGTTGCTGACCAGCCAGAACTTATAAAT
CTGGAGAAAGCTTCCAAAGGTAGAGATGCTGAAAAAACAGTTAGGGAGAGATTAATTAGTTTACAAATGGAAACAACAGGACTTATAGAC
CCTGATAGTAAAGCACCTTTAACAGTTGTGCAGTCCATTGACAGAGGTCTTTTGGAGAGAGAGGAGGCCGTTCGTTTGTTGACTAAGCAA
GTGGTAGATGGAGGTATCATTCACCATATATCTGGGATGAGACTTTCTGTTGATAATGCCTTCAGACATGGCTTAATTGGTGAAGATTTA
GCCGAGAAACTCAAAAGAGTTGAGAACTTAAACATCCATCAGATTTTTAATCCTGAAACGAAGGAAAATATTTCCCTCCCTAAAGCCATA
AAATTAGATCTTATTACCTCAGACCTGAAAAGAGAAATCCAGGAGGTTCAGGCCTTTACTGGAAACTTTGTGGATCTCATTTCTGGTCAG
AGATTGACCTTGGCAGAAGCTAAAAAAGAAGGACTGTTAACTAATGAAGCAGTATTGTCTCCAGGAATGATGCATGGCATTGTAGATCCC
GAGAACTGCAGAATTGTCCCCTACTCAGAATTAGTCAAGAAATGTAAGATTGATATTGAATCTGGACAGAGATATCTAGAAGTAATTCCC
TTCTCAGACATTAAAGATGGGGTGAGCGACAAAGTGCTTACATTGTCTCAAGCAATTCAGCTTGGAAAAGTAGACTTTGCATCTACGCTG
AAGGTTCTAGAAGCCCAGGCAAATACTGGTGGAATCATAGATACTGCTACTGGAAAAAGACTGACATTGGCATCAGCTTTGGAAGAGAAA
CTGGTGGATGAAAACATGGTCAGAATTATTGCATCTCATCAGGTGTTAAATGGAGGAATTGTTGACATATTTAGTGATCAGAGAGTGACT
TTAGTAGAAGCTATTGAGAAAAGACTGATCAGCCCTGAACTGGCAAATATGATCCAAATAGATAGTTCAGAGTTCAGCGATCACAGGGCT
CAGATTGAAAAGCAAGAAGGGATTGAAGTGTGTGCATTACAAAATGAATTTCTAGGAAAGGATATGTTAATTGCTTGTAATCAGACTGCT
GAAATGAGTTGTAATAAAGTAGAAGAGAGTGAGAGATTATTTCAAGTTGAAAATCAGTCTGCACAAGAAAAGGTTAAAGTGAGAGTTTCT
GATGGGGAGCAGGCAAAAAAGAGCAGGGAAATTTCCTTAAAGGAATTTGGGTGCAAGGATCAACGTAAGCCAAGAATGTCTTCAGATGCT
AAAGAATTTATCAGTATCATAAATCCTCATAATCTTAAAGGTAAATCCTTGGGCCAAGTGTCATTGACACACCCTTACTCTGAATGTGAT
TTTAAACTTAAAGAAGTGGCTAGAAATAACATGGGAAATGATACAAATGAAGAGCAGGAAAAAGCAGTGACAAAAATAGAAATTATTTCT
CATATGAAGCAGTCTACCTCATGTCTAGATTCTGAAGAAATAAGAGAAAATCAAGGGGAAGTGATTTTGGAAGTACAAGAAACATATTGT
GAAACGTCAGGCAAATTGCCGAGTGAGCAGGTTTTGCAGCAACCAATGAATGCTCGGGTGAAAAGTAAGAGAGAGAAGAGGGAGGTGATT
GTAGAAGAAAGTATCAGAACATGCAAACCAGCATTTCTTTCTGAAGAAAAGTTGTATCAGGAAACTGCCATTAGAGATGAGCATGACTCC
CATATAAAGAGCCAACCTAGGGAAATGACCTCAAGTGAAAAAGGGAAAGAAGCTGATACAGAAATGGGATTTTCTATTACTTTTAAAATT
GAAGAGTCCTCTTCCCAAGTGGTACCTCAAGGAATTTCTGTAAAACATTTAGATGCTTTAACACTCTTCAGCTCTAAACAGGCCAATGAA
GGAAAAGTAAACAATTTAAGTCTCTGCTTGACTTTAAAACCAGAAGAAAACTTATCTCGAGAAATTGCCTGTGGGGCCCAGAGTGAACCA
TTCCCTTGTATGACCCCAAGACCTGAAGGATTGCACTACCAGGAATCAGATGGAAAAGCCCAAGTGACAGGCCCATCCCAAATTTCCAAA
ACAGACAAGTCTTTCCAAGGAACCACCAGACAGGAGACCAACTATCAAGATTCCTGGGTTACTTCGAAAACTAAGGAAACCAAACATCAA
ATTTCCTCATCTAATGAATGTAAAGAAAAGTCATACCAAGAAGTATCTTTTGACCCAGCAAGAGGTCTTAAATTGGAAGAAATCACAGTT
TCTAGACCAGATTCAAAAGAAGTCAGGTATCTAGAATTCTCAGACAGAAAAGACCTTCATCATCAGGGCAGCAAAAGTGATGATAAACTT
TGTGGAACTCTCAAATCTGAAATAGCAACACAGGAACTAACTGGAGAGAAATTTCTAGAAATGGCAAACCCTAATGTTGCAGGTCTAGAA
GCAGGATCCATTGAGGACATAGTGACTCAGAGAGGTTCCAGAGTCTTGGGATCCTTTCTTCCAGAGAAACTGTTCAAAGGAGTGTCTCAA
AAAGAGAATACAGGGCAACAGAATGCCATCATTAGTCCTACTGTTCTAGAGACCAGTGAAGAAAAGACAGTGTCCCTAACAGTATGCTCT
GCAGTGAAGACAGAGAAGACACCACAGGAAAAGCTCAGAGAAAGCCCTGGCAGTGAACAAACTCCCTTCATGACTGCACCTGAAGGAAAG
GGAAATGGAGGTGTAAACCCAGAGCCCTTCAGAGCAACTCAGAATGTATTTACCCGGCAACTCTGTTTAGAACATGATGAAAAGCTAGTA
TCCTATCTGTCTCTGTTACGGAACATTGAAATGAGGACCAAACAGATTCAACCTTTGGAGCTAAACCTGGCAGAACTACAGGATCTGCTG
TGTCAGGCCAAGGTATTAGAAAGGGAGTTAAAGGATCTGACCACCTTGGTCAGTCAGGAGCTGGAGTGTGTGAATCAGATTATCATCAGC
CAGCCTCAAGAAGTTCCTGCTCAACTGTTGAAGGCTCTAGAGAAAGATGCCAAGAATCTTCAGAAGTCTCTCAGCTCTGTGAGTGACACT
TGGAATTCCAGGCTACTCCACTTCCAGAATGCTGTGGAAATAGAAAAGACTAAAGTGTTAAATCAGCACACACAGCTAGAAGGCCGACTT
CAAGATCTGAGAGCCTGGGTTGGCAATAAAAATCTTATTCTGAACAGCAAGGGATCTAACAGTGAAATAGATGTTGACAGCCTGAACCTC
TGCCTCCAACAGTATGAGGATTTGAAACAGCCCATGGCTGAAAGGAAAGCTCAGCTGGATGCTCTTGCTTTTGATATTCAGTTCTTTATC
TCAGAACATGCCCAGGACTTGTCCCCTCAGCAGAATCGACAGATGCTGAGGCTTCTGAATGAACTGCAGAGGTCCTTCCAGGACATTTTG
GAACAGACTGCCGCTCAGGTGGATGCCTTGCAGGGCCATCTTCAACAAATGGAGCAGGAAGCCCTGGTGAAGACCCTGCAGAAACAACAA
AATACCTGTCACCAGCAACTGGAGGATCTTTGCAGTTGGGTAGGACAGGCAGAAAGAGCACTGGCAGGCCACCAAGGCAGAACCACCCAG
CAGGATCTCTCTGCTTTGCAGAAGAACCAAAGTGACTTGAAGGATTTACAGGATGACATTCAGAATCGTGCCACCTCATTTGCCACTGTT
GTCAAGGACATTGAGGGGTTCATGGAAGAGAATCAGACCAAGCTGAGCCCACGTGAGTTGACAGCTCTTCGGGAAAAGCTTCATCAGGCT
AAGGAGCAATATGAGGCGCTCCAGGAAGAGACACGTGTGGCCCAGAAGGAACTGGAGGAAGCAGTGACCTCCGCCTTACAGCAGGAGACT
GAAAAGAGTAAAGCAGCAAAGGAACTGGCAGAGAACAAGAAGAAGATCGATGCTCTCCTGGATTGGGTAACTTCAGTAGGATCATCTGGT
GGACAGCTGCTGACCAACCTTCCAGGAATGGAGCAGCTCTCGGGAGCTAGCTTGGAGAAAGGAGCCTTGGACACCACTGATGGTTACATG
GGGGTGAATCAAGCCCCAGAGAAACTGGACAAGCAATGTGAGATGATGAAGGCCCGTCACCAAGAATTGCTGTCCCAGCAGCAAAATTTC
ATTCTGGCCACCCAGTCAGCTCAGGCCTTCTTGGATCAGCATGGCCACAATCTCACACCTGAGGAGCAACAGATGCTGCAACAGAAGCTG
GGAGAGCTAAAGGAACAATACTCTACTTCCCTGGCCCAATCAGAGGCAGAACTGAAGCAGGTGCAGACACTTCAGGATGAGTTGCAGAAA
TTTCTGCAGGATCATAAAGAGTTTGAAAGCTGGTTGGAACGATCCGAGAAAGAGCTGGAGAACATGCATAAGGGAGGCAGCAGCCCCGAG
ACCCTTCCCTCCCTGCTAAAGCGGCAAGGAAGCTTCTCAGAGGATGTCATTTCCCACAAAGGAGACTTGAGATTTGTGACTATCTCAGGA
CAGAAAGTCTTGGACATGGAAAACAGTTTTAAGGAAGGCAAAGAACCATCAGAAATTGGAAACTTAGTAAAGGACAAGTTGAAGGATGCA
ACAGAAAGATACACTGCTCTCCACTCAAAGTGTACACGATTAGGATCTCACCTGAATATGCTGTTAGGCCAGTATCATCAATTCCAAAAC
AGTGCTGACAGCCTGCAGGCCTGGATGCAGGCTTGTGAGGCCAACGTGGAGAAGCTCCTCTCAGATACTGTTGCCTCTGACCCTGGAGTT
CTCCAGGAGCAGCTTGCAACAACAAAGCAGTTGCAGGAGGAATTGGCTGAGCACCAAGTACCTGTGGAAAAACTCCAAAAAGTAGCTCGT
GACATAATGGAAATTGAAGGGGAGCCAGCCCCAGACCACAGGCATGTTCAAGAAACTACAGATTCCATACTCAGCCACTTCCAAAGCCTC
TCCTATAGCCTGGCTGAGCGATCTTCTCTGCTGCAGAAAGCAATTGCCCAATCTCAGAGTGTCCAGGAAAGCCTGGAGAGCCTGTTGCAG
TCTATTGGGGAAGTTGAACAAAACCTGGAAGGGAAGCAGGTGTCATCACTCTCATCAGGAGTCATCCAGGAAGCCTTAGCCACAAATATG
AAATTGAAGCAGGACATTGCTCGGCAAAAGAGCAGCTTGGAGGCCACCCGTGAGATGGTGACCCGATTCATGGAGACAGCAGACAGTACT
ACAGCAGCAGTGCTGCAGGGCAAACTGGCAGAGGTGAGCCAGCGGTTCGAACAGCTCTGTCTACAGCAGCAAGAAAAGGAGAGCTCCCTA
AAGAAGCTTCTACCCCAGGCAGAGATGTTTGAACACCTCTCTGGTAAGCTGCAGCAGTTCATGGAAAACAAAAGTCGGATGCTGGCCTCT
GGAAATCAGCCAGATCAAGATATTACACATTTCTTCCAACAGATCCAGGAGCTCAATTTGGAAATGGAAGACCAACAGGAGAACCTAGAT
ACTCTTGAGCACCTGGTCACTGAACTGAGCTCTTGTGGCTTTGCGCTGGACTTGTGCCAGCATCAGGACAGGGTACAGAATCTAAGAAAA
GACTTCACAGAGCTACAGAAGACAGTTAAAGAGAGAGAGAAAGATGCATCATCTTGCCAGGAACAGTTGGATGAATTCCGGAAGCTGGTC
AGGACCTTCCAGAAATGGTTGAAAGAAACTGAAGGGAGTATTCCACCTACGGAAACTTCTATGAGTGCTAAAGAGTTAGAAAAGCAGATT
GAACACCTGAAGAGTCTACTAGATGACTGGGCAAGTAAGGGAACTCTGGTGGAAGAAATCAATTGCAAAGGTACTTCTTTAGAAAATCTC
ATCATGGAAATCACAGCACCTGATTCCCAAGGCAAGACAGGTTCCATACTGCCCTCTGTAGGAAGCTCTGTAGGCAGTGTAAACGGATAC
CACACCTGCAAAGATCTGACGGAGATCCAGTGTGACATGTCAGATGTAAACTTGAAGTATGAGAAACTAGGGGGAGTACTTCATGAACGC
CAGGAAAGCCTTCAGGCTATCCTCAACAGAATGGAGGAGGTTCACAAGGAGGCAAACTCTGTGCTGCAGTGGCTGGAATCAAAAGAGGAA
GTCCTGAAATCCATGGATGCCATGTCATCTCCAACCAAGACAGAAACAGTGAAAGCCCAAGCTGAATCTAACAAGGCCTTCCTGGCTGAG
TTGGAACAGAATTCTCCAAAAATTCAAAAAGTAAAGGAAGCCCTGGCTGGATTACTGGTGACATATCCCAACTCACAGGAAGCAGAAAAT
TGGAAGAAAATTCAGGAAGAACTCAATTCCCGATGGGAAAGGGCCACTGAGGTTACTGTGGCTCGGCAAAGGCAGCTAGAGGAATCTGCA
AGTCATCTGGCCTGCTTCCAGGCTGCAGAATCCCAGCTCCGGCCGTGGCTGATGGAGAAAGAACTGATGATGGGAGTGCTGGGGCCCCTG
TCTATTGACCCCAACATGTTGAATGCACAAAAGCAACAGGTCCAGTTTATGCTAAAGGAATTTGAAGCACGCAGGCAACAGCATGAGCAA
CTGAATGAGGCAGCTCAGGGCATCCTAACAGGCCCTGGAGATGTCTCTCTGTCCACCAGCCAAGTACAGAAAGAACTCCAGAGCATCAAT
CAGAAATGGGTTGAGCTGACTGACAAACTCAACTCCCGTTCCAGCCAAATTGACCAAGCTATTGTTAAGAGCACCCAGTACCAGGAACTG
CTCCAGGACTTATCAGAGAAGGTGAGGGCAGTTGGACAACGGCTGAGTGTCCAGTCAGCTATCAGCACCCAACCAGAGGCTGTAAAGCAG
CAATTGGAAGAGACCAGTGAAATTCGATCTGACTTGGAGCAGTTAGACCACGAGGTTAAGGAGGCTCAGACACTGTGCGATGAACTCTCA
GTGCTCATTGGTGAGCAGTACCTCAAGGATGAACTGAAGAAGCGTTTGGAGACAGTTGCCCTGCCTCTCCAAGGTTTAGAAGACCTTGCA
GCCGATCGCATTAACAGACTCCAGGCAGCTCTTGCCAGCACCCAGCAGTTCCAGCAAATGTTTGATGAGTTGAGGACCTGGTTGGATGAT
AAACAAAGCCAGCAAGCAAAAAACTGCCCAATTTCTGCAAAATTGGAGCGGCTACAGTCTCAGCTACAGGAGAATGAAGAGTTTCAGAAA
AGTCTTAATCAACACAGTGGCTCCTATGAGGTGATTGTGGCTGAAGGGGAATCTCTACTTCTTTCTGTACCTCCTGGAGAAGAGAAAAGG
ACTCTACAAAACCAGTTGGTTGAGCTCAAAAACCATTGGGAAGAGCTTAGTAAAAAAACTGCAGACAGACAATCCAGGCTCAAGGATTGT
ATGCAGAAAGCTCAGAAATATCAGTGGCATGTGGAAGACCTTGTGCCATGGATAGAAGATTGTAAAGCTAAGATGTCTGAGTTGCGAGTC
ACTCTGGATCCAGTGCAGCTAGAGTCCAGTCTCCTAAGATCAAAGGCTATGCTGAATGAGGTGGAGAAGCGCCGCTCCCTGCTGGAAATA
TTGAATAGTGCTGCTGACATTCTGATCAATTCTTCAGAAGCAGATGAGGATGGAATCCGGGATGAGAAGGCTGGGATCAACCAGAACATG
GATGCTGTTACAGAAGAGCTGCAGGCCAAAACAGGGTCACTCGAAGAAATGACTCAGAGGCTCAGGGAGTTCCAGGAAAGCTTTAAGAAT
ATTGAAAAGAAGGTTGAAGGAGCCAAACACCAACTTGAGATCTTTGATGCTCTGGGTTCTCAAGCCTGTAGCAACAAGAACCTGGAGAAG
CTAAGAGCTCAACAGGAAGTGCTGCAGGCCCTAGAGCCTCAGGTAGACTATCTGAGGAACTTTACTCAGGGTCTGGTAGAAGATGCCCCA
GATGGATCTGATGCTTCTCAACTTCTCCACCAAGCTGAGGTCGCCCAGCAAGAGTTCCTCGAAGTTAAGCAAAGAGTGAACAGTGGTTGT
GTGATGATGGAAAACAAGCTGGAGGGGATTGGCCAGTTTCACTGCCGGGTCCGAGAGATGTTCTCTCAATTGGCAGACCTGGATGATGAG
CTAGATGGCATGGGTGCTATTGGCAGAGACACTGATAGCCTCCAGTCCCAAATCGAGGATGTCCGGCTATTCCTTAACAAAATTCACGTC
CTCAAATTAGACATAGAGGCCTCTGAAGCAGAGTGTCGACATATGCTAGAAGAAGAGGGGACTCTGGATTTGTTAGGTCTCAAAAGGGAG
CTAGAAGCCCTGAACAAACAGTGTGGCAAACTGACAGAGAGGGGGAAAGCTCGTCAGGAACAGCTGGAACTGACACTAGGCCGTGTAGAG
GACTTCTACAGGAAATTGAAAGGACTCAATGACGCGACCACAGCAGCAGAGGAGGCAGAGGCCCTCCAGTGGGTAGTGGGGACCGAAGTG
GAAATCATCAACCAACAATTAGCAGATTTTAAAATGTTTCAGAAAGAACAAGTGGATCCTCTTCAGATGAAATTGCAGCAGGTGAATGGA
CTTGGCCAGGGATTAATTCAGAGTGCAGGAAAAGACTGTGATGTACAGGGTTTAGAACATGACATGGAAGAGATCAATGCTCGATGGAAT
ACATTGAATAAAAAGGTCGCACAAAGAATTGCACAGCTACAGGAAGCTTTGTTGCATTGTGGGAAGTTTCAAGATGCCTTGGAGCCATTG
CTCAGCTGGTTGGCAGATACCGAGGAGCTCATAGCCAATCAGAAACCTCCATCTGCTGAGTATAAAGTGGTGAAAGCACAGATCCAAGAA
CAGAAGTTGCTCCAGCGGCTCCTAGATGATCGAAAGGCCACAGTAGACATGCTTCAAGCAGAAGGAGGCAGAATAGCCCAGTCAGCAGAG
CTGGCTGATAGAGAGAAAATCACTGGACAGCTGGAGAGTCTTGAAAGTAGATGGACTGAACTACTCAGTAAGGCAGCAGCCAGGCAAAAA
CAGCTGGAAGACATCCTGGTTCTGGCCAAACAGTTCCATGAGACAGCTGAGCCTATTTCTGACTTCTTATCTGTCACAGAGAAAAAGCTT
GCTAACTCAGAACCTGTTGGCACTCAGACTGCCAAAATACAGCAGCAGATCATTCGGCACAAGGCTCTGGAAGAAGACATAGAAAACCAT
GCAACAGATGTGCACCAGGCAGTCAAAATTGGGCAGTCCCTCTCCTCCCTGACATCTCCTGCAGAACAGGGTGTGCTGTCAGAAAAGATA
GACTCATTGCAGGCCCGATACAGTGAAATTCAAGACCGCTGTTGTCGGAAGGCAGCCCTACTTGACCAAGCTCTGTCTAATGCTAGGCTG
TTTGGGGAGGATGAGGTGGAGGTGCTCAACTGGCTGGCTGAGGTTGAGGACAAGCTCAGTTCAGTGTTCGTAAAGGATTTCAAACAGGAT
GTCCTGCACAGGCAGCATGCTGACCACCTGGCTTTAAATGAAGAAATTGTTAATAGAAAGAAGAATGTAGATCAAGCTATTAAAAATGGT
CAGGCTCTTCTAAAACAAACCACAGGTGAGGAGGTGTTACTTATCCAGGAAAAACTAGATGGTATAAAGACTCGTTACGCAGACATCACA
GTTACTAGCTCCAAGGCCCTCAGAACTTTAGAGCAAGCCCGGCAGCTGGCCACCAAGTTCCAGTCTACTTATGAGGAACTGACCGGGTGG
CTGAGGGAGGTGGAGGAGGAGCTGGCAACCAGTGGAGGACAGTCTCCCACAGGGGAACAGATACCCCAGTTTCAGCAGAGACAGAAGGAA
TTAAAGAAGGAGGTCATGGAGCACAGGCTGGTGTTGGACACAGTGAATGAGGTGAGCCGTGCTCTCTTAGAGCTGGTGCCCTGGAGAGCC
AGAGAAGGGCTGGATAAACTTGTGTCCGATGCTAACGAGCAGTACAAACTAGTCAGTGACACTATTGGACAAAGGGTGGATGAAATTGAT
GCTGCTATTCAGAGATCACAACAGGACTTGATTAGAGACCAAGGATTTCGTGGTGATGGAGGATCAACCACAGGTTTGTCTGCTACCCCC
CCTGCCTCATTACCTGGCTCACTAACTAACGTGAAAGCCTTACAGAAATCTCCAGGACCTCAGCGAGAAAGGAAGTCATCTTCATCCTCA
GAAGACAGGAATCGAATGAAAACACTTGGTAGACGGGACTCGAGTGATGATTGGGAGATTCCTGATGGGCAGATTACAGTGGGACAAAGA
ATTGGATCTGGATCATTTGGAACAGTCTACAAGGGAAAGTGGCATGGTGATGTGGCAGTGAAAATGTTGAATGTGACAGCACCTACACCT
CAGCAGTTACAAGCCTTCAAAAATGAAGTAGGAGTACTCAGGAAAACACGACATGTGAATATCCTACTCTTCATGGGCTATTCCACAAAG
CCACAACTGGCTATTGTTACCCAGTGGTGTGAGGGCTCCAGCTTGTATCACCATCTCCATATCATTGAGACCAAATTTGAGATGATCAAA
CTTATAGATATTGCACGACAGACTGCACAGGGCATGGATTACTTACACGCCAAGTCAATCATCCACAGAGACCTCAAGAGTAATAATATA
TTTCTTCATGAAGACCTCACAGTAAAAATAGGTGATTTTGGTCTAGCTACAGTGAAATCTCGATGGAGTGGGTCCCATCAGTTTGAACAG
TTGTCTGGATCCATTTTGTGGATGGCACCAGAAGTCATCAGAATGCAAGATAAAAATCCATACAGCTTTCAGTCAGATGTATATGCATTT
GGAATTGTTCTGTATGAATTGATGACTGGACAGTTACCTTATTCAAACATCAACAACAGGGACCAGATAATTTTTATGGTGGGACGAGGA
TACCTGTCTCCAGATCTCAGTAAGGTACGGAGTAACTGTCCAAAAGCCATGAAGAGATTAATGGCAGAGTGCCTCAAAAAGAAAAGAGAT
GAGAGACCACTCTTTCCCCAAATTCTCGCCTCTATTGAGCTGCTGGCCCGCTCATTGCCAAAAATTCACCGCAGTGCATCAGAACCCTCC
TTGAATCGGGCTGGTTTCCAAACAGAGGATTTTAGTCTATATGCTTGTGCTTCTCCAAAAACACCCATCCAGGCAGGGGGATATGGTGCG
TTTCCTGTCCACTGAAACAAATGAGTGAGAGAGTTCAGGAGAGTAGCAACAAAAGGAAAATAAATGAACATATGTTTGCTTATATGTTAA

>50588_50588_7_MACF1-BRAF_MACF1_chr1_39896580_ENST00000564288_BRAF_chr7_140487384_ENST00000288602_length(amino acids)=6167AA_BP=5781
MEMPLLDSSYLPPTIFILTHVLGVAGVLYWKRHARGRADERDRVQKKTFTKWVNKHLMKVRKHINDLYEDLRDGHNLISLLEVLSGIKLE
PAGLKTLRLVSMPSWCHTNNEEQAEEDDDDVPREKGRMRFHRLQNVQIALDFLKQRQVKLVNIRNDDITDGNPKLTLGLIWTIILHFQIS
DIYISGESGDMSAKEKLLLWTQKVTAGYTGIKCTNFSSCWSDGKMFNALIHRYRPDLVDMERVQIQSNRENLEQAFEVAERLGVTRLLDA
EDVDVPSPDEKSVITYVSSIYDAFPKVPEGGEGISATEVDSRWQEYQSRVDSLIPWIKQHTILMSDKTFPQNPVELKALYNQYIHFKETE
ILAKEREKGRIEELYKLLEVWIEFGRIKLPQGYHPNDVEEEWGKLIIEMLEREKSLRPAVERLELLLQIANKIQNGALNCEEKLTLAKNT
LQADAAHLESGQPVQCESDVIMYIQECEGLIRQLQVDLQILRDENYYQLEELAFRVMRLQDELVTLRLECTNLYRKGHFTSLELVPPSTL
TTTHLKAEPLTKATHSSSTSWFRKPMTRAELVAISSSEDEGNLRFVYELLSWVEEMQMKLERAEWGNDLPSVELQLETQQHIHTSVEELG
SSVKEARLYEGKMSQNFHTSYAETLGKLETQYCKLKETSSFRMRHLQSLHKFVSRATAELIWLNEKEEEELAYDWSDNNSNISAKRNYFS
ELTMELEEKQDVFRSLQDTAELLSLENHPAKQTVEAYSAAVQSQLQWMKQLCLCVEQHVKENTAYFQFFSDARELESFLRNLQDSIKRKY
SCDHNTSLSRLEDLLQDSMDEKEQLIQSKSSVASLVGRSKTIVQLKPRSPDHVLKNTISVKAVCDYRQIEITICKNDECVLEDNSQRTKW
KVISPTGNEAMVPSVCFLIPPPNKDAIEMASRVEQSYQKVMALWHQLHVNTKSLISWNYLRKDLDLVQTWNLEKLRSSAPGECHQIMKNL
QAHYEDFLQDSRDSVLFSVADRLRLEEEVEACKARFQHLMKSMENEDKEETVAKMYISELKNIRLRLEEYEQRVVKRIQSLASSRTDRDA
WQDNALRIAEQEHTQEDLQQLRSDLDAVSMKCDSFLHQSPSSSSVPTLRSELNLLVEKMDHVYGLSTVYLNKLKTVDVIVRSIQDAELLV
KGYEIKLSQEEVVLADLSALEAHWSTLRHWLSDVKDKNSVFSVLDEEIAKAKVVAEQMSRLTPERNLDLERYQEKGSQLQERWHRVIAQL
EIRQSELESIQEVLGDYRACHGTLIKWIEETTAQQEMMKPGQAEDSRVLSEQLSQQTALFAEIERNQTKLDQCQKFSQQYSTIVKDYELQ
LMTYKAFVESQQKSPGKRRRMLSSSDAITQEFMDLRTRYTALVTLTTQHVKYISDALRRLEEEEKVVEEEKQEHVEKVKELLGWVSTLAR
NTQGKATSSETKESTDIEKAILEQQVLSEELTTKKEQVSEAIKTSQIFLAKHGHKLSEKEKKQISEQLNALNKAYHDLCDGSANQLQQLQ
SQLAHQTEQKECRAVAGVIDLGTVEIFPIFKAMQKGLLDQDTGLVLLESQVIMSGLIAPETGENLSLEEGIARNLINPQMYQQLRELQDA
LALISRLTESRGPLSVVEAIEKRIISETVGLKILEAHLATGGFSLSPSENCINLEEAFHQGLISAWLHSVLESYLRTSKNLIDPNTAEKI
GLLDLMQRCIVHQESGFKLLPVKQLAGGMVSLKSGRKVSIFRAVQEGLIDRQVTVRLLEAQLFAGGIVDPRTGHRLTVEEAVRHNLIDQD
MACAILIRQLQTGGIIDTVTGQRLTIDEAVSNDLVAAKIALVILESLWSFMGLLWPESGEILPITDALEQGIVSTELAHKILSNRQHIKA
LFLPATTEILSWKKAIESGILDRDLANNLKSICIPDVMPHMQLADSAEQNINPGAAVLPCSKSHPKATASQSENLLFQLMTHSYINVQNG
QRLLLLDKELMETLTSRDEYQTSPPKVVEIGHQRQKTPEGLQESANVKISGTFSSGWTVRLPEFQFSSQNKEYPDREDCTTEKGKKTTVE
TEDSSVENPEQDLFVEQKERNPNIDALKVINKVKLEVQRQLIGTQREDQTAVSVRENASRGHLLTIPPAEAEGVPLVVDKDVFSVETPKK
EHQPLRNTSFTCQNEQAHTLETEYIHDETGGSHIKPQSKKLQVQVKKTLGIKLELKSETDGNVHPLDKKEMLKKTFLAKDDHKESQEAQN
IAGGSMMMSEKTDEEDSGREIFLSCSHPLELLEEATLNVLSAQLLDGGIFHEQTGQKLLLNEAISRGIVPSHTAVKLMEKLNMFQGFFDS
QTCESLTTEEVINEGLMDEKLLHNVLMADKAISGVLDPRTQTLCSVKDAVTVGLLDKETATRILERQVVTGGIIDLKRGKKVSVTLASTL
GLVDVADQPELINLEKASKGRDAEKTVRERLISLQMETTGLIDPDSKAPLTVVQSIDRGLLEREEAVRLLTKQVVDGGIIHHISGMRLSV
DNAFRHGLIGEDLAEKLKRVENLNIHQIFNPETKENISLPKAIKLDLITSDLKREIQEVQAFTGNFVDLISGQRLTLAEAKKEGLLTNEA
VLSPGMMHGIVDPENCRIVPYSELVKKCKIDIESGQRYLEVIPFSDIKDGVSDKVLTLSQAIQLGKVDFASTLKVLEAQANTGGIIDTAT
GKRLTLASALEEKLVDENMVRIIASHQVLNGGIVDIFSDQRVTLVEAIEKRLISPELANMIQIDSSEFSDHRAQIEKQEGIEVCALQNEF
LGKDMLIACNQTAEMSCNKVEESERLFQVENQSAQEKVKVRVSDGEQAKKSREISLKEFGCKDQRKPRMSSDAKEFISIINPHNLKGKSL
GQVSLTHPYSECDFKLKEVARNNMGNDTNEEQEKAVTKIEIISHMKQSTSCLDSEEIRENQGEVILEVQETYCETSGKLPSEQVLQQPMN
ARVKSKREKREVIVEESIRTCKPAFLSEEKLYQETAIRDEHDSHIKSQPREMTSSEKGKEADTEMGFSITFKIEESSSQVVPQGISVKHL
DALTLFSSKQANEGKVNNLSLCLTLKPEENLSREIACGAQSEPFPCMTPRPEGLHYQESDGKAQVTGPSQISKTDKSFQGTTRQETNYQD
SWVTSKTKETKHQISSSNECKEKSYQEVSFDPARGLKLEEITVSRPDSKEVRYLEFSDRKDLHHQGSKSDDKLCGTLKSEIATQELTGEK
FLEMANPNVAGLEAGSIEDIVTQRGSRVLGSFLPEKLFKGVSQKENTGQQNAIISPTVLETSEEKTVSLTVCSAVKTEKTPQEKLRESPG
SEQTPFMTAPEGKGNGGVNPEPFRATQNVFTRQLCLEHDEKLVSYLSLLRNIEMRTKQIQPLELNLAELQDLLCQAKVLERELKDLTTLV
SQELECVNQIIISQPQEVPAQLLKALEKDAKNLQKSLSSVSDTWNSRLLHFQNAVEIEKTKVLNQHTQLEGRLQDLRAWVGNKNLILNSK
GSNSEIDVDSLNLCLQQYEDLKQPMAERKAQLDALAFDIQFFISEHAQDLSPQQNRQMLRLLNELQRSFQDILEQTAAQVDALQGHLQQM
EQEALVKTLQKQQNTCHQQLEDLCSWVGQAERALAGHQGRTTQQDLSALQKNQSDLKDLQDDIQNRATSFATVVKDIEGFMEENQTKLSP
RELTALREKLHQAKEQYEALQEETRVAQKELEEAVTSALQQETEKSKAAKELAENKKKIDALLDWVTSVGSSGGQLLTNLPGMEQLSGAS
LEKGALDTTDGYMGVNQAPEKLDKQCEMMKARHQELLSQQQNFILATQSAQAFLDQHGHNLTPEEQQMLQQKLGELKEQYSTSLAQSEAE
LKQVQTLQDELQKFLQDHKEFESWLERSEKELENMHKGGSSPETLPSLLKRQGSFSEDVISHKGDLRFVTISGQKVLDMENSFKEGKEPS
EIGNLVKDKLKDATERYTALHSKCTRLGSHLNMLLGQYHQFQNSADSLQAWMQACEANVEKLLSDTVASDPGVLQEQLATTKQLQEELAE
HQVPVEKLQKVARDIMEIEGEPAPDHRHVQETTDSILSHFQSLSYSLAERSSLLQKAIAQSQSVQESLESLLQSIGEVEQNLEGKQVSSL
SSGVIQEALATNMKLKQDIARQKSSLEATREMVTRFMETADSTTAAVLQGKLAEVSQRFEQLCLQQQEKESSLKKLLPQAEMFEHLSGKL
QQFMENKSRMLASGNQPDQDITHFFQQIQELNLEMEDQQENLDTLEHLVTELSSCGFALDLCQHQDRVQNLRKDFTELQKTVKEREKDAS
SCQEQLDEFRKLVRTFQKWLKETEGSIPPTETSMSAKELEKQIEHLKSLLDDWASKGTLVEEINCKGTSLENLIMEITAPDSQGKTGSIL
PSVGSSVGSVNGYHTCKDLTEIQCDMSDVNLKYEKLGGVLHERQESLQAILNRMEEVHKEANSVLQWLESKEEVLKSMDAMSSPTKTETV
KAQAESNKAFLAELEQNSPKIQKVKEALAGLLVTYPNSQEAENWKKIQEELNSRWERATEVTVARQRQLEESASHLACFQAAESQLRPWL
MEKELMMGVLGPLSIDPNMLNAQKQQVQFMLKEFEARRQQHEQLNEAAQGILTGPGDVSLSTSQVQKELQSINQKWVELTDKLNSRSSQI
DQAIVKSTQYQELLQDLSEKVRAVGQRLSVQSAISTQPEAVKQQLEETSEIRSDLEQLDHEVKEAQTLCDELSVLIGEQYLKDELKKRLE
TVALPLQGLEDLAADRINRLQAALASTQQFQQMFDELRTWLDDKQSQQAKNCPISAKLERLQSQLQENEEFQKSLNQHSGSYEVIVAEGE
SLLLSVPPGEEKRTLQNQLVELKNHWEELSKKTADRQSRLKDCMQKAQKYQWHVEDLVPWIEDCKAKMSELRVTLDPVQLESSLLRSKAM
LNEVEKRRSLLEILNSAADILINSSEADEDGIRDEKAGINQNMDAVTEELQAKTGSLEEMTQRLREFQESFKNIEKKVEGAKHQLEIFDA
LGSQACSNKNLEKLRAQQEVLQALEPQVDYLRNFTQGLVEDAPDGSDASQLLHQAEVAQQEFLEVKQRVNSGCVMMENKLEGIGQFHCRV
REMFSQLADLDDELDGMGAIGRDTDSLQSQIEDVRLFLNKIHVLKLDIEASEAECRHMLEEEGTLDLLGLKRELEALNKQCGKLTERGKA
RQEQLELTLGRVEDFYRKLKGLNDATTAAEEAEALQWVVGTEVEIINQQLADFKMFQKEQVDPLQMKLQQVNGLGQGLIQSAGKDCDVQG
LEHDMEEINARWNTLNKKVAQRIAQLQEALLHCGKFQDALEPLLSWLADTEELIANQKPPSAEYKVVKAQIQEQKLLQRLLDDRKATVDM
LQAEGGRIAQSAELADREKITGQLESLESRWTELLSKAAARQKQLEDILVLAKQFHETAEPISDFLSVTEKKLANSEPVGTQTAKIQQQI
IRHKALEEDIENHATDVHQAVKIGQSLSSLTSPAEQGVLSEKIDSLQARYSEIQDRCCRKAALLDQALSNARLFGEDEVEVLNWLAEVED
KLSSVFVKDFKQDVLHRQHADHLALNEEIVNRKKNVDQAIKNGQALLKQTTGEEVLLIQEKLDGIKTRYADITVTSSKALRTLEQARQLA
TKFQSTYEELTGWLREVEEELATSGGQSPTGEQIPQFQQRQKELKKEVMEHRLVLDTVNEVSRALLELVPWRAREGLDKLVSDANEQYKL
VSDTIGQRVDEIDAAIQRSQQDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDD
WEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYH
HLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQD
KNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLAR

--------------------------------------------------------------
>50588_50588_8_MACF1-BRAF_MACF1_chr1_39896580_ENST00000567887_BRAF_chr7_140487384_ENST00000288602_length(transcript)=18884nt_BP=17605nt
GAAACTGAGGTACAGATAGGCAGGACTAGAACCTCTGCTTCCCAAGTCCCAGTGTTCCTTATGGGACCCCTTTTGTCTGCTCACATTCAC
CCCTTTCTCCTTCAGATCACTTCTCCCTGGGCTCCCAGGCCCTCCTGCAGCAGCCCCCGCCTGGGCCATGTCTTCCTCAGATGAAGAGAC
GCTCAGTGAGCGGTCATGTCGGAGTGAGCGGTCTTGTCGGAGTGAGCGATCTTACAGGAGCGAGCGGTCGGGGAGCCTGTCTCCCTGTCC
CCCAGGGGACACCTTGCCCTGGAACCTGCCACTGCATGAGCAGAAAAAGCGGAAAAGCCAGGATTCGGTGCTGGACCCTGCAGAGCGTGC
TGTGGTCAGAGTCGCTGATGAACGGGACCGGGTTCAGAAGAAAACGTTCACCAAGTGGGTCAACAAGCACTTAATGAAGGTCCGCAAGCA
CATCAATGATCTTTATGAAGATCTGCGGGATGGCCATAACCTGATCTCTCTGTTGGAGGTCCTCTCAGGCATCAAACTGGAGCCAGCAGG
GCTGAAGACCCTCCGTCTGGTGAGCATGCCCTCCTGGTGCCATACAAACAACGAGGAGCAGGCGGAGGAAGATGATGATGATGTACCCCG
GGAGAAGGGCAGGATGCGTTTTCATAGGCTGCAGAATGTGCAGATTGCCCTGGACTTCCTAAAGCAGCGACAGGTGAAACTAGTGAATAT
TCGCAATGATGACATCACAGATGGCAACCCCAAGTTGACCCTGGGTCTGATCTGGACCATTATTTTGCATTTCCAGATCTCTGACATCTA
CATTAGTGGAGAATCAGGGGATATGTCAGCCAAGGAGAAACTACTCCTGTGGACCCAGAAGGTGACAGCTGGTTACACAGGAATCAAATG
CACCAACTTTTCCTCCTGCTGGAGTGATGGGAAGATGTTCAATGCACTCATTCACCGATACCGACCCGATCTAGTAGACATGGAGAGGGT
GCAAATCCAAAGTAACCGAGAGAATCTGGAACAGGCTTTTGAAGTGGCAGAAAGACTGGGGGTCACTCGCCTGCTGGATGCAGAAGATGT
GGATGTGCCATCTCCAGATGAAAAGTCTGTAATCACTTATGTGTCTTCGATTTATGATGCCTTCCCTAAAGTTCCTGAGGGTGGAGAAGG
GATCAGTGCTACGGAAGTGGACTCCAGGTGGCAAGAATACCAAAGCCGAGTGGACTCCCTCATTCCCTGGATCAAACAGCATACAATACT
GATGTCAGATAAAACTTTTCCCCAAAACCCTGTTGAACTAAAGGCACTTTATAACCAATATATACACTTCAAAGAAACAGAAATTCTGGC
CAAGGAGAGAGAAAAAGGAAGAATTGAGGAATTATATAAATTACTAGAGGTGTGGATTGAATTTGGCCGAATTAAACTGCCTCAAGGTTA
TCACCCTAATGATGTGGAAGAAGAGTGGGGAAAGCTCATCATAGAGATGCTGGAACGAGAGAAATCACTTCGGCCGGCTGTGGAGAGGCT
GGAATTGCTGCTACAGATTGCAAACAAAATCCAGAATGGTGCTTTGAACTGTGAAGAAAAACTGACACTAGCTAAGAATACACTGCAGGC
TGATGCTGCTCACCTGGAATCAGGACAACCGGTACAATGTGAGTCAGATGTCATTATGTACATTCAGGAGTGTGAAGGTCTCATCAGGCA
GCTGCAGGTGGATCTCCAGATCCTGCGGGATGAGAATTACTACCAGCTAGAAGAGCTGGCTTTTAGGGTCATGCGTCTTCAGGATGAGCT
GGTCACCTTGCGTCTAGAGTGTACAAACCTGTACCGGAAGGGTCATTTCACTTCACTTGAATTGGTTCCACCCTCTACTTTAACCACCAC
TCATCTGAAAGCAGAACCCTTAACCAAGGCAACCCATTCTTCTTCTACCTCCTGGTTCCGAAAGCCTATGACTCGGGCTGAACTTGTGGC
CATCAGCTCCTCTGAAGATGAAGGCAATCTCCGATTTGTGTATGAACTACTGTCTTGGGTAGAAGAGATGCAGATGAAACTGGAGCGAGC
AGAGTGGGGCAATGACCTGCCTAGTGTGGAGTTGCAGCTAGAAACACAGCAGCACATCCATACGAGTGTAGAAGAGCTGGGCTCAAGTGT
CAAGGAGGCCAGGTTGTATGAGGGAAAGATGTCCCAGAATTTCCATACCAGCTATGCTGAAACTCTTGGAAAGCTGGAGACACAGTATTG
TAAATTGAAGGAAACTTCTAGCTTCCGGATGAGGCACCTTCAGAGCCTGCATAAATTTGTTTCCAGAGCTACAGCTGAGTTGATCTGGTT
GAATGAGAAGGAGGAGGAGGAACTAGCATATGACTGGAGTGACAACAATTCCAATATCTCAGCCAAGAGAAATTACTTCTCTGAGTTGAC
AATGGAACTGGAGGAGAAACAGGATGTGTTTCGTTCTCTACAAGATACAGCAGAACTACTTTCACTTGAGAACCACCCAGCCAAGCAGAC
AGTGGAGGCTTACAGTGCTGCTGTCCAGTCCCAGTTGCAGTGGATGAAGCAGCTGTGCCTGTGTGTTGAGCAGCATGTGAAAGAGAATAC
TGCTTATTTTCAGTTCTTCAGTGATGCACGAGAGCTGGAGTCATTCTTGAGGAACCTCCAAGATTCCATTAAACGAAAATATTCCTGTGA
CCACAACACCAGCTTATCCCGCCTTGAAGACCTGCTCCAGGACTCCATGGATGAAAAGGAGCAGCTTATACAGTCCAAGAGTTCCGTTGC
CAGTCTCGTTGGGAGATCAAAAACCATCGTTCAGCTAAAACCACGCAGTCCAGACCATGTGTTAAAGAACACCATTTCTGTCAAGGCTGT
CTGTGACTACAGGCAGATCGAGATTACTATTTGCAAAAATGATGAATGTGTGCTAGAAGATAATTCTCAGCGGACCAAATGGAAAGTGAT
CAGCCCCACAGGGAACGAGGCAATGGTGCCGTCAGTCTGCTTCCTCATCCCCCCACCCAATAAGGATGCCATTGAGATGGCCAGCAGGGT
CGAACAATCTTATCAGAAGGTTATGGCCCTTTGGCATCAGCTGCATGTTAACACCAAAAGCCTTATCTCTTGGAACTATCTGCGTAAAGA
CCTTGACCTTGTACAGACCTGGAACCTAGAAAAGCTTCGATCCTCAGCACCAGGGGAGTGCCATCAGATTATGAAGAACCTTCAGGCCCA
CTATGAAGACTTTCTGCAGGATAGTCGTGACTCTGTGCTGTTCTCAGTGGCTGATCGCTTGCGCTTGGAAGAGGAGGTGGAAGCTTGTAA
AGCCCGCTTCCAGCACCTGATGAAGTCCATGGAGAATGAGGACAAAGAGGAGACTGTGGCCAAGATGTACATTTCAGAGTTGAAGAACAT
CCGGCTACGCCTGGAGGAGTATGAACAGAGGGTGGTCAAACGAATTCAGTCTCTAGCCAGCTCTAGGACTGACAGAGATGCCTGGCAGGA
CAATGCATTAAGGATTGCAGAGCAAGAGCACACCCAGGAGGATTTACAGCAATTGAGGTCAGACTTGGATGCAGTTTCTATGAAATGTGA
CAGCTTTCTCCATCAGTCTCCATCTAGTTCAAGTGTCCCAACTCTGCGCTCAGAACTGAATCTGCTGGTGGAGAAGATGGACCATGTCTA
TGGTCTCTCTACTGTATATCTGAATAAGTTAAAGACAGTTGATGTTATAGTACGTAGCATACAGGATGCTGAACTCTTGGTCAAAGGTTA
TGAGATTAAGCTGAGTCAAGAAGAAGTAGTACTGGCAGATCTCTCAGCTCTGGAGGCCCATTGGTCGACATTACGGCACTGGCTTAGTGA
TGTGAAGGACAAGAATTCAGTGTTTTCAGTCCTGGATGAGGAAATTGCCAAGGCCAAGGTAGTGGCAGAGCAGATGAGTCGTCTGACACC
AGAGCGAAATCTGGATTTGGAGCGCTATCAGGAAAAAGGCTCCCAGCTGCAGGAGCGTTGGCACCGAGTCATTGCCCAGCTCGAGATTCG
CCAATCTGAGCTAGAAAGTATCCAGGAAGTTCTGGGAGATTACCGAGCCTGCCATGGAACTCTCATCAAGTGGATTGAGGAAACCACTGC
CCAGCAGGAAATGATGAAGCCAGGCCAGGCAGAGGATAGCAGAGTGCTTTCGGAGCAGCTCAGCCAGCAGACGGCCCTATTTGCAGAAAT
TGAGAGAAATCAGACAAAACTGGATCAATGTCAAAAATTTTCCCAGCAGTACTCTACTATTGTAAAGGACTATGAATTGCAACTGATGAC
ATACAAGGCCTTTGTGGAATCGCAGCAGAAATCCCCTGGCAAGCGCCGTCGCATGCTTTCCTCTTCAGATGCCATCACTCAAGAGTTCAT
GGACTTAAGGACTCGCTACACGGCATTGGTGACTTTAACAACTCAGCACGTGAAATACATCAGTGATGCACTCCGGCGTCTGGAGGAGGA
GGAGAAAGTGGTAGAAGAGGAGAAACAAGAACATGTGGAGAAGGTTAAAGAACTTTTGGGCTGGGTGTCTACCCTAGCGAGGAATACACA
AGGAAAAGCTACCTCATCCGAGACCAAAGAATCAACAGACATTGAAAAAGCTATTTTGGAACAGCAGGTTCTGTCAGAAGAGCTGACAAC
AAAGAAAGAACAAGTCTCTGAAGCTATTAAAACATCACAGATCTTCTTGGCCAAGCATGGTCATAAGCTCTCAGAAAAAGAGAAGAAACA
AATATCTGAGCAATTGAATGCCCTAAACAAGGCTTACCATGACCTTTGTGATGGTTCTGCAAATCAGCTTCAGCAGCTTCAGAGCCAGTT
GGCTCACCAGACAGAACAAAAGGAATGCAGAGCAGTTGCTGGGGTGATTGACCTAGGCACAGTGGAGATATTTCCCATCTTCAAAGCCAT
GCAAAAGGGCCTCCTTGACCAAGACACAGGCCTAGTGCTTCTGGAATCTCAGGTTATCATGTCTGGCCTCATTGCCCCTGAGACGGGTGA
AAACCTCTCTTTGGAGGAGGGCATAGCCAGAAACCTCATTAATCCCCAGATGTACCAGCAGCTCCGGGAGCTACAGGATGCCCTGGCCTT
AATAAGCAGGCTTACTGAGAGCAGAGGCCCTCTTTCTGTGGTGGAAGCAATTGAAAAGAGAATAATCAGTGAGACAGTTGGACTGAAAAT
CTTAGAAGCTCACCTGGCAACTGGAGGTTTCAGTCTTTCCCCTAGTGAGAACTGTATTAACCTGGAAGAGGCTTTTCATCAAGGCCTCAT
TTCTGCATGGCTTCATTCAGTATTAGAGTCTTATCTTAGAACATCCAAGAATTTGATAGACCCTAACACAGCTGAGAAAATTGGTTTGCT
GGATCTGATGCAGCGATGTATTGTCCACCAGGAATCAGGATTCAAATTACTGCCTGTCAAACAATTGGCAGGGGGGATGGTGAGCTTGAA
ATCAGGCCGGAAGGTTAGCATTTTCCGTGCAGTTCAGGAAGGGCTAATAGATAGGCAGGTCACTGTCCGGTTGCTGGAAGCTCAGCTTTT
TGCTGGTGGCATAGTAGATCCAAGAACAGGACACAGACTTACAGTGGAAGAGGCTGTAAGACATAATCTGATTGACCAAGATATGGCCTG
TGCTATCCTCATAAGGCAGCTTCAGACAGGAGGCATCATAGACACTGTCACGGGGCAAAGGCTAACAATAGATGAAGCAGTGAGCAATGA
TCTAGTAGCTGCTAAGATCGCCCTTGTGATTCTGGAGTCCCTCTGGTCATTCATGGGGTTGCTGTGGCCTGAATCTGGAGAGATCCTCCC
AATTACAGATGCCCTAGAACAAGGTATTGTGTCTACTGAACTAGCACATAAAATCCTTAGTAACCGACAGCATATTAAGGCTCTGTTTCT
ACCAGCAACCACAGAGATTTTGTCCTGGAAGAAAGCAATAGAAAGTGGTATCCTGGATAGAGATCTTGCCAATAACTTAAAATCGATTTG
TATACCTGATGTGATGCCCCACATGCAACTAGCAGACTCTGCAGAACAAAATATTAATCCTGGAGCAGCAGTTCTACCGTGCAGCAAGAG
CCACCCTAAGGCCACAGCAAGCCAGAGTGAGAATCTGTTGTTCCAGCTGATGACTCACAGCTATATTAATGTGCAAAATGGACAGAGGCT
GCTTCTGTTAGATAAAGAGCTGATGGAGACACTAACATCCAGAGATGAGTATCAAACAAGTCCTCCAAAAGTGGTTGAAATTGGGCATCA
AAGGCAAAAAACTCCTGAGGGATTGCAAGAATCAGCTAATGTGAAAATCTCAGGAACTTTCAGCAGTGGGTGGACTGTGAGGCTGCCTGA
GTTCCAGTTTTCTTCTCAGAACAAAGAATATCCCGATCGGGAAGATTGCACTACAGAAAAAGGCAAAAAGACCACTGTAGAAACAGAAGA
TTCTTCTGTAGAGAACCCTGAACAGGATCTGTTTGTAGAACAAAAAGAGAGAAATCCAAACATTGATGCTTTGAAGGTAATAAATAAAGT
CAAATTAGAGGTACAAAGGCAGTTGATAGGTACCCAAAGGGAAGACCAAACAGCAGTGTCTGTCAGAGAAAATGCCAGCAGGGGACACCT
CCTGACCATACCTCCTGCTGAGGCGGAAGGTGTGCCGTTGGTGGTTGACAAAGATGTTTTTTCTGTTGAAACACCAAAGAAAGAACATCA
ACCTCTAAGAAACACTTCCTTTACATGTCAGAATGAACAAGCACACACTCTTGAGACTGAATATATTCATGATGAAACTGGAGGATCTCA
CATAAAACCCCAAAGCAAAAAGTTACAAGTTCAGGTAAAGAAAACTCTAGGTATAAAGTTAGAACTAAAGTCTGAAACTGATGGGAATGT
TCATCCTCTGGACAAAAAGGAAATGTTAAAGAAAACATTTCTGGCTAAGGATGACCATAAAGAAAGTCAAGAAGCACAGAACATCGCAGG
TGGTAGTATGATGATGTCAGAAAAGACCGATGAGGAAGATAGTGGCAGGGAAATTTTTCTGTCATGCAGTCATCCATTAGAATTGCTTGA
AGAAGCTACCTTAAATGTATTATCTGCACAGTTACTAGATGGTGGTATCTTTCATGAACAAACAGGTCAAAAGCTCTTACTAAATGAAGC
AATATCCCGAGGCATTGTGCCAAGTCACACTGCCGTGAAGCTTATGGAGAAGCTGAACATGTTTCAGGGGTTCTTTGACTCTCAGACTTG
TGAGTCTTTGACAACTGAAGAAGTCATTAATGAAGGTCTGATGGATGAGAAATTATTACATAATGTCCTCATGGCAGACAAAGCTATAAG
TGGTGTCTTAGACCCCCGTACCCAGACACTGTGCTCTGTAAAGGATGCAGTTACAGTTGGACTTCTTGACAAGGAAACAGCCACCAGAAT
TTTAGAGAGGCAGGTGGTGACTGGTGGAATTATTGATCTGAAACGAGGCAAAAAAGTTTCAGTAACTTTGGCCTCAACTCTTGGCTTGGT
GGACGTTGCTGACCAGCCAGAACTTATAAATCTGGAGAAAGCTTCCAAAGGTAGAGATGCTGAAAAAACAGTTAGGGAGAGATTAATTAG
TTTACAAATGGAAACAACAGGACTTATAGACCCTGATAGTAAAGCACCTTTAACAGTTGTGCAGTCCATTGACAGAGGTCTTTTGGAGAG
AGAGGAGGCCGTTCGTTTGTTGACTAAGCAAGTGGTAGATGGAGGTATCATTCACCATATATCTGGGATGAGACTTTCTGTTGATAATGC
CTTCAGACATGGCTTAATTGGTGAAGATTTAGCCGAGAAACTCAAAAGAGTTGAGAACTTAAACATCCATCAGATTTTTAATCCTGAAAC
GAAGGAAAATATTTCCCTCCCTAAAGCCATAAAATTAGATCTTATTACCTCAGACCTGAAAAGAGAAATCCAGGAGGTTCAGGCCTTTAC
TGGAAACTTTGTGGATCTCATTTCTGGTCAGAGATTGACCTTGGCAGAAGCTAAAAAAGAAGGACTGTTAACTAATGAAGCAGTATTGTC
TCCAGGAATGATGCATGGCATTGTAGATCCCGAGAACTGCAGAATTGTCCCCTACTCAGAATTAGTCAAGAAATGTAAGATTGATATTGA
ATCTGGACAGAGATATCTAGAAGTAATTCCCTTCTCAGACATTAAAGATGGGGTGAGCGACAAAGTGCTTACATTGTCTCAAGCAATTCA
GCTTGGAAAAGTAGACTTTGCATCTACGCTGAAGGTTCTAGAAGCCCAGGCAAATACTGGTGGAATCATAGATACTGCTACTGGAAAAAG
ACTGACATTGGCATCAGCTTTGGAAGAGAAACTGGTGGATGAAAACATGGTCAGAATTATTGCATCTCATCAGGTGTTAAATGGAGGAAT
TGTTGACATATTTAGTGATCAGAGAGTGACTTTAGTAGAAGCTATTGAGAAAAGACTGATCAGCCCTGAACTGGCAAATATGATCCAAAT
AGATAGTTCAGAGTTCAGCGATCACAGGGCTCAGATTGAAAAGCAAGAAGGGATTGAAGTGTGTGCATTACAAAATGAATTTCTAGGAAA
GGATATGTTAATTGCTTGTAATCAGACTGCTGAAATGAGTTGTAATAAAGTAGAAGAGAGTGAGAGATTATTTCAAGTTGAAAATCAGTC
TGCACAAGAAAAGGTTAAAGTGAGAGTTTCTGATGGGGAGCAGGCAAAAAAGAGCAGGGAAATTTCCTTAAAGGAATTTGGGTGCAAGGA
TCAACGTAAGCCAAGAATGTCTTCAGATGCTAAAGAATTTATCAGTATCATAAATCCTCATAATCTTAAAGGTAAATCCTTGGGCCAAGT
GTCATTGACACACCCTTACTCTGAATGTGATTTTAAACTTAAAGAAGTGGCTAGAAATAACATGGGAAATGATACAAATGAAGAGCAGGA
AAAAGCAGTGACAAAAATAGAAATTATTTCTCATATGAAGCAGTCTACCTCATGTCTAGATTCTGAAGAAATAAGAGAAAATCAAGGGGA
AGTGATTTTGGAAGTACAAGAAACATATTGTGAAACGTCAGGCAAATTGCCGAGTGAGCAGGTTTTGCAGCAACCAATGAATGCTCGGGT
GAAAAGTAAGAGAGAGAAGAGGGAGGTGATTGTAGAAGAAAGTATCAGAACATGCAAACCAGCATTTCTTTCTGAAGAAAAGTTGTATCA
GGAAACTGCCATTAGAGATGAGCATGACTCCCATATAAAGAGCCAACCTAGGGAAATGACCTCAAGTGAAAAAGGGAAAGAAGCTGATAC
AGAAATGGGATTTTCTATTACTTTTAAAATTGAAGAGTCCTCTTCCCAAGTGGTACCTCAAGGAATTTCTGTAAAACATTTAGATGCTTT
AACACTCTTCAGCTCTAAACAGGCCAATGAAGGAAAAGTAAACAATTTAAGTCTCTGCTTGACTTTAAAACCAGAAGAAAACTTATCTCG
AGAAATTGCCTGTGGGGCCCAGAGTGAACCATTCCCTTGTATGACCCCAAGACCTGAAGGATTGCACTACCAGGAATCAGATGGAAAAGC
CCAAGTGACAGGCCCATCCCAAATTTCCAAAACAGACAAGTCTTTCCAAGGAACCACCAGACAGGAGACCAACTATCAAGATTCCTGGGT
TACTTCGAAAACTAAGGAAACCAAACATCAAATTTCCTCATCTAATGAATGTAAAGAAAAGTCATACCAAGAAGTATCTTTTGACCCAGC
AAGAGGTCTTAAATTGGAAGAAATCACAGTTTCTAGACCAGATTCAAAAGAAGTCAGGTATCTAGAATTCTCAGACAGAAAAGACCTTCA
TCATCAGGGCAGCAAAAGTGATGATAAACTTTGTGGAACTCTCAAATCTGAAATAGCAACACAGGAACTAACTGGAGAGAAATTTCTAGA
AATGGCAAACCCTAATGTTGCAGGTCTAGAAGCAGGATCCATTGAGGACATAGTGACTCAGAGAGGTTCCAGAGTCTTGGGATCCTTTCT
TCCAGAGAAACTGTTCAAAGGAGTGTCTCAAAAAGAGAATACAGGGCAACAGAATGCCATCATTAGTCCTACTGTTCTAGAGACCAGTGA
AGAAAAGACAGTGTCCCTAACAGTATGCTCTGCAGTGAAGACAGAGAAGACACCACAGGAAAAGCTCAGAGAAAGCCCTGGCAGTGAACA
AACTCCCTTCATGACTGCACCTGAAGGAAAGGGAAATGGAGGTGTAAACCCAGAGCCCTTCAGAGCAACTCAGAATGTATTTACCCGGCA
ACTCTGTTTAGAACATGATGAAAAGCTAGTATCCTATCTGTCTCTGTTACGGAACATTGAAATGAGGACCAAACAGATTCAACCTTTGGA
GCTAAACCTGGCAGAACTACAGGATCTGCTGTGTCAGGCCAAGGTATTAGAAAGGGAGTTAAAGGATCTGACCACCTTGGTCAGTCAGGA
GCTGGAGTGTGTGAATCAGATTATCATCAGCCAGCCTCAAGAAGTTCCTGCTCAACTGTTGAAGGCTCTAGAGAAAGATGCCAAGAATCT
TCAGAAGTCTCTCAGCTCTGTGAGTGACACTTGGAATTCCAGGCTACTCCACTTCCAGAATGCTGTGGAAATAGAAAAGACTAAAGTGTT
AAATCAGCACACACAGCTAGAAGGCCGACTTCAAGATCTGAGAGCCTGGGTTGGCAATAAAAATCTTATTCTGAACAGCAAGGGATCTAA
CAGTGAAATAGATGTTGACAGCCTGAACCTCTGCCTCCAACAGTATGAGGATTTGAAACAGCCCATGGCTGAAAGGAAAGCTCAGCTGGA
TGCTCTTGCTTTTGATATTCAGTTCTTTATCTCAGAACATGCCCAGGACTTGTCCCCTCAGCAGAATCGACAGATGCTGAGGCTTCTGAA
TGAACTGCAGAGGTCCTTCCAGGACATTTTGGAACAGACTGCCGCTCAGGTGGATGCCTTGCAGGGCCATCTTCAACAAATGGAGCAGGA
AGCCCTGGTGAAGACCCTGCAGAAACAACAAAATACCTGTCACCAGCAACTGGAGGATCTTTGCAGTTGGGTAGGACAGGCAGAAAGAGC
ACTGGCAGGCCACCAAGGCAGAACCACCCAGCAGGATCTCTCTGCTTTGCAGAAGAACCAAAGTGACTTGAAGGATTTACAGGATGACAT
TCAGAATCGTGCCACCTCATTTGCCACTGTTGTCAAGGACATTGAGGGGTTCATGGAAGAGAATCAGACCAAGCTGAGCCCACGTGAGTT
GACAGCTCTTCGGGAAAAGCTTCATCAGGCTAAGGAGCAATATGAGGCGCTCCAGGAAGAGACACGTGTGGCCCAGAAGGAACTGGAGGA
AGCAGTGACCTCCGCCTTACAGCAGGAGACTGAAAAGAGTAAAGCAGCAAAGGAACTGGCAGAGAACAAGAAGAAGATCGATGCTCTCCT
GGATTGGGTAACTTCAGTAGGATCATCTGGTGGACAGCTGCTGACCAACCTTCCAGGAATGGAGCAGCTCTCGGGAGCTAGCTTGGAGAA
AGGAGCCTTGGACACCACTGATGGTTACATGGGGGTGAATCAAGCCCCAGAGAAACTGGACAAGCAATGTGAGATGATGAAGGCCCGTCA
CCAAGAATTGCTGTCCCAGCAGCAAAATTTCATTCTGGCCACCCAGTCAGCTCAGGCCTTCTTGGATCAGCATGGCCACAATCTCACACC
TGAGGAGCAACAGATGCTGCAACAGAAGCTGGGAGAGCTAAAGGAACAATACTCTACTTCCCTGGCCCAATCAGAGGCAGAACTGAAGCA
GGTGCAGACACTTCAGGATGAGTTGCAGAAATTTCTGCAGGATCATAAAGAGTTTGAAAGCTGGTTGGAACGATCCGAGAAAGAGCTGGA
GAACATGCATAAGGGAGGCAGCAGCCCCGAGACCCTTCCCTCCCTGCTAAAGCGGCAAGGAAGCTTCTCAGAGGATGTCATTTCCCACAA
AGGAGACTTGAGATTTGTGACTATCTCAGGACAGAAAGTCTTGGACATGGAAAACAGTTTTAAGGAAGGCAAAGAACCATCAGAAATTGG
AAACTTAGTAAAGGACAAGTTGAAGGATGCAACAGAAAGATACACTGCTCTCCACTCAAAGTGTACACGATTAGGATCTCACCTGAATAT
GCTGTTAGGCCAGTATCATCAATTCCAAAACAGTGCTGACAGCCTGCAGGCCTGGATGCAGGCTTGTGAGGCCAACGTGGAGAAGCTCCT
CTCAGATACTGTTGCCTCTGACCCTGGAGTTCTCCAGGAGCAGCTTGCAACAACAAAGCAGTTGCAGGAGGAATTGGCTGAGCACCAAGT
ACCTGTGGAAAAACTCCAAAAAGTAGCTCGTGACATAATGGAAATTGAAGGGGAGCCAGCCCCAGACCACAGGCATGTTCAAGAAACTAC
AGATTCCATACTCAGCCACTTCCAAAGCCTCTCCTATAGCCTGGCTGAGCGATCTTCTCTGCTGCAGAAAGCAATTGCCCAATCTCAGAG
TGTCCAGGAAAGCCTGGAGAGCCTGTTGCAGTCTATTGGGGAAGTTGAACAAAACCTGGAAGGGAAGCAGGTGTCATCACTCTCATCAGG
AGTCATCCAGGAAGCCTTAGCCACAAATATGAAATTGAAGCAGGACATTGCTCGGCAAAAGAGCAGCTTGGAGGCCACCCGTGAGATGGT
GACCCGATTCATGGAGACAGCAGACAGTACTACAGCAGCAGTGCTGCAGGGCAAACTGGCAGAGGTGAGCCAGCGGTTCGAACAGCTCTG
TCTACAGCAGCAAGAAAAGGAGAGCTCCCTAAAGAAGCTTCTACCCCAGGCAGAGATGTTTGAACACCTCTCTGGTAAGCTGCAGCAGTT
CATGGAAAACAAAAGTCGGATGCTGGCCTCTGGAAATCAGCCAGATCAAGATATTACACATTTCTTCCAACAGATCCAGGAGCTCAATTT
GGAAATGGAAGACCAACAGGAGAACCTAGATACTCTTGAGCACCTGGTCACTGAACTGAGCTCTTGTGGCTTTGCGCTGGACTTGTGCCA
GCATCAGGACAGGGTACAGAATCTAAGAAAAGACTTCACAGAGCTACAGAAGACAGTTAAAGAGAGAGAGAAAGATGCATCATCTTGCCA
GGAACAGTTGGATGAATTCCGGAAGCTGGTCAGGACCTTCCAGAAATGGTTGAAAGAAACTGAAGGGAGTATTCCACCTACGGAAACTTC
TATGAGTGCTAAAGAGTTAGAAAAGCAGATTGAACACCTGAAGAGTCTACTAGATGACTGGGCAAGTAAGGGAACTCTGGTGGAAGAAAT
CAATTGCAAAGGTACTTCTTTAGAAAATCTCATCATGGAAATCACAGCACCTGATTCCCAAGGCAAGACAGGTTCCATACTGCCCTCTGT
AGGAAGCTCTGTAGGCAGTGTAAACGGATACCACACCTGCAAAGATCTGACGGAGATCCAGTGTGACATGTCAGATGTAAACTTGAAGTA
TGAGAAACTAGGGGGAGTACTTCATGAACGCCAGGAAAGCCTTCAGGCTATCCTCAACAGAATGGAGGAGGTTCACAAGGAGGCAAACTC
TGTGCTGCAGTGGCTGGAATCAAAAGAGGAAGTCCTGAAATCCATGGATGCCATGTCATCTCCAACCAAGACAGAAACAGTGAAAGCCCA
AGCTGAATCTAACAAGGCCTTCCTGGCTGAGTTGGAACAGAATTCTCCAAAAATTCAAAAAGTAAAGGAAGCCCTGGCTGGATTACTGGT
GACATATCCCAACTCACAGGAAGCAGAAAATTGGAAGAAAATTCAGGAAGAACTCAATTCCCGATGGGAAAGGGCCACTGAGGTTACTGT
GGCTCGGCAAAGGCAGCTAGAGGAATCTGCAAGTCATCTGGCCTGCTTCCAGGCTGCAGAATCCCAGCTCCGGCCGTGGCTGATGGAGAA
AGAACTGATGATGGGAGTGCTGGGGCCCCTGTCTATTGACCCCAACATGTTGAATGCACAAAAGCAACAGGTCCAGTTTATGCTAAAGGA
ATTTGAAGCACGCAGGCAACAGCATGAGCAACTGAATGAGGCAGCTCAGGGCATCCTAACAGGCCCTGGAGATGTCTCTCTGTCCACCAG
CCAAGTACAGAAAGAACTCCAGAGCATCAATCAGAAATGGGTTGAGCTGACTGACAAACTCAACTCCCGTTCCAGCCAAATTGACCAAGC
TATTGTTAAGAGCACCCAGTACCAGGAACTGCTCCAGGACTTATCAGAGAAGGTGAGGGCAGTTGGACAACGGCTGAGTGTCCAGTCAGC
TATCAGCACCCAACCAGAGGCTGTAAAGCAGCAATTGGAAGAGACCAGTGAAATTCGATCTGACTTGGAGCAGTTAGACCACGAGGTTAA
GGAGGCTCAGACACTGTGCGATGAACTCTCAGTGCTCATTGGTGAGCAGTACCTCAAGGATGAACTGAAGAAGCGTTTGGAGACAGTTGC
CCTGCCTCTCCAAGGTTTAGAAGACCTTGCAGCCGATCGCATTAACAGACTCCAGGCAGCTCTTGCCAGCACCCAGCAGTTCCAGCAAAT
GTTTGATGAGTTGAGGACCTGGTTGGATGATAAACAAAGCCAGCAAGCAAAAAACTGCCCAATTTCTGCAAAATTGGAGCGGCTACAGTC
TCAGCTACAGGAGAATGAAGAGTTTCAGAAAAGTCTTAATCAACACAGTGGCTCCTATGAGGTGATTGTGGCTGAAGGGGAATCTCTACT
TCTTTCTGTACCTCCTGGAGAAGAGAAAAGGACTCTACAAAACCAGTTGGTTGAGCTCAAAAACCATTGGGAAGAGCTTAGTAAAAAAAC
TGCAGACAGACAATCCAGGCTCAAGGATTGTATGCAGAAAGCTCAGAAATATCAGTGGCATGTGGAAGACCTTGTGCCATGGATAGAAGA
TTGTAAAGCTAAGATGTCTGAGTTGCGAGTCACTCTGGATCCAGTGCAGCTAGAGTCCAGTCTCCTAAGATCAAAGGCTATGCTGAATGA
GGTGGAGAAGCGCCGCTCCCTGCTGGAAATATTGAATAGTGCTGCTGACATTCTGATCAATTCTTCAGAAGCAGATGAGGATGGAATCCG
GGATGAGAAGGCTGGGATCAACCAGAACATGGATGCTGTTACAGAAGAGCTGCAGGCCAAAACAGGGTCACTCGAAGAAATGACTCAGAG
GCTCAGGGAGTTCCAGGAAAGCTTTAAGAATATTGAAAAGAAGGTTGAAGGAGCCAAACACCAACTTGAGATCTTTGATGCTCTGGGTTC
TCAAGCCTGTAGCAACAAGAACCTGGAGAAGCTAAGAGCTCAACAGGAAGTGCTGCAGGCCCTAGAGCCTCAGGTAGACTATCTGAGGAA
CTTTACTCAGGGTCTGGTAGAAGATGCCCCAGATGGATCTGATGCTTCTCAACTTCTCCACCAAGCTGAGGTCGCCCAGCAAGAGTTCCT
CGAAGTTAAGCAAAGAGTGAACAGTGGTTGTGTGATGATGGAAAACAAGCTGGAGGGGATTGGCCAGTTTCACTGCCGGGTCCGAGAGAT
GTTCTCTCAATTGGCAGACCTGGATGATGAGCTAGATGGCATGGGTGCTATTGGCAGAGACACTGATAGCCTCCAGTCCCAAATCGAGGA
TGTCCGGCTATTCCTTAACAAAATTCACGTCCTCAAATTAGACATAGAGGCCTCTGAAGCAGAGTGTCGACATATGCTAGAAGAAGAGGG
GACTCTGGATTTGTTAGGTCTCAAAAGGGAGCTAGAAGCCCTGAACAAACAGTGTGGCAAACTGACAGAGAGGGGGAAAGCTCGTCAGGA
ACAGCTGGAACTGACACTAGGCCGTGTAGAGGACTTCTACAGGAAATTGAAAGGACTCAATGACGCGACCACAGCAGCAGAGGAGGCAGA
GGCCCTCCAGTGGGTAGTGGGGACCGAAGTGGAAATCATCAACCAACAATTAGCAGATTTTAAAATGTTTCAGAAAGAACAAGTGGATCC
TCTTCAGATGAAATTGCAGCAGGTGAATGGACTTGGCCAGGGATTAATTCAGAGTGCAGGAAAAGACTGTGATGTACAGGGTTTAGAACA
TGACATGGAAGAGATCAATGCTCGATGGAATACATTGAATAAAAAGGTCGCACAAAGAATTGCACAGCTACAGGAAGCTTTGTTGCATTG
TGGGAAGTTTCAAGATGCCTTGGAGCCATTGCTCAGCTGGTTGGCAGATACCGAGGAGCTCATAGCCAATCAGAAACCTCCATCTGCTGA
GTATAAAGTGGTGAAAGCACAGATCCAAGAACAGAAGTTGCTCCAGCGGCTCCTAGATGATCGAAAGGCCACAGTAGACATGCTTCAAGC
AGAAGGAGGCAGAATAGCCCAGTCAGCAGAGCTGGCTGATAGAGAGAAAATCACTGGACAGCTGGAGAGTCTTGAAAGTAGATGGACTGA
ACTACTCAGTAAGGCAGCAGCCAGGCAAAAACAGCTGGAAGACATCCTGGTTCTGGCCAAACAGTTCCATGAGACAGCTGAGCCTATTTC
TGACTTCTTATCTGTCACAGAGAAAAAGCTTGCTAACTCAGAACCTGTTGGCACTCAGACTGCCAAAATACAGCAGCAGATCATTCGGCA
CAAGGCTCTGGAAGAAGACATAGAAAACCATGCAACAGATGTGCACCAGGCAGTCAAAATTGGGCAGTCCCTCTCCTCCCTGACATCTCC
TGCAGAACAGGGTGTGCTGTCAGAAAAGATAGACTCATTGCAGGCCCGATACAGTGAAATTCAAGACCGCTGTTGTCGGAAGGCAGCCCT
ACTTGACCAAGCTCTGTCTAATGCTAGGCTGTTTGGGGAGGATGAGGTGGAGGTGCTCAACTGGCTGGCTGAGGTTGAGGACAAGCTCAG
TTCAGTGTTCGTAAAGGATTTCAAACAGGATGTCCTGCACAGGCAGCATGCTGACCACCTGGCTTTAAATGAAGAAATTGTTAATAGAAA
GAAGAATGTAGATCAAGCTATTAAAAATGGTCAGGCTCTTCTAAAACAAACCACAGGTGAGGAGGTGTTACTTATCCAGGAAAAACTAGA
TGGTATAAAGACTCGTTACGCAGACATCACAGTTACTAGCTCCAAGGCCCTCAGAACTTTAGAGCAAGCCCGGCAGCTGGCCACCAAGTT
CCAGTCTACTTATGAGGAACTGACCGGGTGGCTGAGGGAGGTGGAGGAGGAGCTGGCAACCAGTGGAGGACAGTCTCCCACAGGGGAACA
GATACCCCAGTTTCAGCAGAGACAGAAGGAATTAAAGAAGGAGGTCATGGAGCACAGGCTGGTGTTGGACACAGTGAATGAGGTGAGCCG
TGCTCTCTTAGAGCTGGTGCCCTGGAGAGCCAGAGAAGGGCTGGATAAACTTGTGTCCGATGCTAACGAGCAGTACAAACTAGTCAGTGA
CACTATTGGACAAAGGGTGGATGAAATTGATGCTGCTATTCAGAGATCACAACAGGACTTGATTAGAGACCAAGGATTTCGTGGTGATGG
AGGATCAACCACAGGTTTGTCTGCTACCCCCCCTGCCTCATTACCTGGCTCACTAACTAACGTGAAAGCCTTACAGAAATCTCCAGGACC
TCAGCGAGAAAGGAAGTCATCTTCATCCTCAGAAGACAGGAATCGAATGAAAACACTTGGTAGACGGGACTCGAGTGATGATTGGGAGAT
TCCTGATGGGCAGATTACAGTGGGACAAAGAATTGGATCTGGATCATTTGGAACAGTCTACAAGGGAAAGTGGCATGGTGATGTGGCAGT
GAAAATGTTGAATGTGACAGCACCTACACCTCAGCAGTTACAAGCCTTCAAAAATGAAGTAGGAGTACTCAGGAAAACACGACATGTGAA
TATCCTACTCTTCATGGGCTATTCCACAAAGCCACAACTGGCTATTGTTACCCAGTGGTGTGAGGGCTCCAGCTTGTATCACCATCTCCA
TATCATTGAGACCAAATTTGAGATGATCAAACTTATAGATATTGCACGACAGACTGCACAGGGCATGGATTACTTACACGCCAAGTCAAT
CATCCACAGAGACCTCAAGAGTAATAATATATTTCTTCATGAAGACCTCACAGTAAAAATAGGTGATTTTGGTCTAGCTACAGTGAAATC
TCGATGGAGTGGGTCCCATCAGTTTGAACAGTTGTCTGGATCCATTTTGTGGATGGCACCAGAAGTCATCAGAATGCAAGATAAAAATCC
ATACAGCTTTCAGTCAGATGTATATGCATTTGGAATTGTTCTGTATGAATTGATGACTGGACAGTTACCTTATTCAAACATCAACAACAG
GGACCAGATAATTTTTATGGTGGGACGAGGATACCTGTCTCCAGATCTCAGTAAGGTACGGAGTAACTGTCCAAAAGCCATGAAGAGATT
AATGGCAGAGTGCCTCAAAAAGAAAAGAGATGAGAGACCACTCTTTCCCCAAATTCTCGCCTCTATTGAGCTGCTGGCCCGCTCATTGCC
AAAAATTCACCGCAGTGCATCAGAACCCTCCTTGAATCGGGCTGGTTTCCAAACAGAGGATTTTAGTCTATATGCTTGTGCTTCTCCAAA
AACACCCATCCAGGCAGGGGGATATGGTGCGTTTCCTGTCCACTGAAACAAATGAGTGAGAGAGTTCAGGAGAGTAGCAACAAAAGGAAA

>50588_50588_8_MACF1-BRAF_MACF1_chr1_39896580_ENST00000567887_BRAF_chr7_140487384_ENST00000288602_length(amino acids)=6243AA_BP=5857
MLPKSQCSLWDPFCLLTFTPFSFRSLLPGLPGPPAAAPAWAMSSSDEETLSERSCRSERSCRSERSYRSERSGSLSPCPPGDTLPWNLPL
HEQKKRKSQDSVLDPAERAVVRVADERDRVQKKTFTKWVNKHLMKVRKHINDLYEDLRDGHNLISLLEVLSGIKLEPAGLKTLRLVSMPS
WCHTNNEEQAEEDDDDVPREKGRMRFHRLQNVQIALDFLKQRQVKLVNIRNDDITDGNPKLTLGLIWTIILHFQISDIYISGESGDMSAK
EKLLLWTQKVTAGYTGIKCTNFSSCWSDGKMFNALIHRYRPDLVDMERVQIQSNRENLEQAFEVAERLGVTRLLDAEDVDVPSPDEKSVI
TYVSSIYDAFPKVPEGGEGISATEVDSRWQEYQSRVDSLIPWIKQHTILMSDKTFPQNPVELKALYNQYIHFKETEILAKEREKGRIEEL
YKLLEVWIEFGRIKLPQGYHPNDVEEEWGKLIIEMLEREKSLRPAVERLELLLQIANKIQNGALNCEEKLTLAKNTLQADAAHLESGQPV
QCESDVIMYIQECEGLIRQLQVDLQILRDENYYQLEELAFRVMRLQDELVTLRLECTNLYRKGHFTSLELVPPSTLTTTHLKAEPLTKAT
HSSSTSWFRKPMTRAELVAISSSEDEGNLRFVYELLSWVEEMQMKLERAEWGNDLPSVELQLETQQHIHTSVEELGSSVKEARLYEGKMS
QNFHTSYAETLGKLETQYCKLKETSSFRMRHLQSLHKFVSRATAELIWLNEKEEEELAYDWSDNNSNISAKRNYFSELTMELEEKQDVFR
SLQDTAELLSLENHPAKQTVEAYSAAVQSQLQWMKQLCLCVEQHVKENTAYFQFFSDARELESFLRNLQDSIKRKYSCDHNTSLSRLEDL
LQDSMDEKEQLIQSKSSVASLVGRSKTIVQLKPRSPDHVLKNTISVKAVCDYRQIEITICKNDECVLEDNSQRTKWKVISPTGNEAMVPS
VCFLIPPPNKDAIEMASRVEQSYQKVMALWHQLHVNTKSLISWNYLRKDLDLVQTWNLEKLRSSAPGECHQIMKNLQAHYEDFLQDSRDS
VLFSVADRLRLEEEVEACKARFQHLMKSMENEDKEETVAKMYISELKNIRLRLEEYEQRVVKRIQSLASSRTDRDAWQDNALRIAEQEHT
QEDLQQLRSDLDAVSMKCDSFLHQSPSSSSVPTLRSELNLLVEKMDHVYGLSTVYLNKLKTVDVIVRSIQDAELLVKGYEIKLSQEEVVL
ADLSALEAHWSTLRHWLSDVKDKNSVFSVLDEEIAKAKVVAEQMSRLTPERNLDLERYQEKGSQLQERWHRVIAQLEIRQSELESIQEVL
GDYRACHGTLIKWIEETTAQQEMMKPGQAEDSRVLSEQLSQQTALFAEIERNQTKLDQCQKFSQQYSTIVKDYELQLMTYKAFVESQQKS
PGKRRRMLSSSDAITQEFMDLRTRYTALVTLTTQHVKYISDALRRLEEEEKVVEEEKQEHVEKVKELLGWVSTLARNTQGKATSSETKES
TDIEKAILEQQVLSEELTTKKEQVSEAIKTSQIFLAKHGHKLSEKEKKQISEQLNALNKAYHDLCDGSANQLQQLQSQLAHQTEQKECRA
VAGVIDLGTVEIFPIFKAMQKGLLDQDTGLVLLESQVIMSGLIAPETGENLSLEEGIARNLINPQMYQQLRELQDALALISRLTESRGPL
SVVEAIEKRIISETVGLKILEAHLATGGFSLSPSENCINLEEAFHQGLISAWLHSVLESYLRTSKNLIDPNTAEKIGLLDLMQRCIVHQE
SGFKLLPVKQLAGGMVSLKSGRKVSIFRAVQEGLIDRQVTVRLLEAQLFAGGIVDPRTGHRLTVEEAVRHNLIDQDMACAILIRQLQTGG
IIDTVTGQRLTIDEAVSNDLVAAKIALVILESLWSFMGLLWPESGEILPITDALEQGIVSTELAHKILSNRQHIKALFLPATTEILSWKK
AIESGILDRDLANNLKSICIPDVMPHMQLADSAEQNINPGAAVLPCSKSHPKATASQSENLLFQLMTHSYINVQNGQRLLLLDKELMETL
TSRDEYQTSPPKVVEIGHQRQKTPEGLQESANVKISGTFSSGWTVRLPEFQFSSQNKEYPDREDCTTEKGKKTTVETEDSSVENPEQDLF
VEQKERNPNIDALKVINKVKLEVQRQLIGTQREDQTAVSVRENASRGHLLTIPPAEAEGVPLVVDKDVFSVETPKKEHQPLRNTSFTCQN
EQAHTLETEYIHDETGGSHIKPQSKKLQVQVKKTLGIKLELKSETDGNVHPLDKKEMLKKTFLAKDDHKESQEAQNIAGGSMMMSEKTDE
EDSGREIFLSCSHPLELLEEATLNVLSAQLLDGGIFHEQTGQKLLLNEAISRGIVPSHTAVKLMEKLNMFQGFFDSQTCESLTTEEVINE
GLMDEKLLHNVLMADKAISGVLDPRTQTLCSVKDAVTVGLLDKETATRILERQVVTGGIIDLKRGKKVSVTLASTLGLVDVADQPELINL
EKASKGRDAEKTVRERLISLQMETTGLIDPDSKAPLTVVQSIDRGLLEREEAVRLLTKQVVDGGIIHHISGMRLSVDNAFRHGLIGEDLA
EKLKRVENLNIHQIFNPETKENISLPKAIKLDLITSDLKREIQEVQAFTGNFVDLISGQRLTLAEAKKEGLLTNEAVLSPGMMHGIVDPE
NCRIVPYSELVKKCKIDIESGQRYLEVIPFSDIKDGVSDKVLTLSQAIQLGKVDFASTLKVLEAQANTGGIIDTATGKRLTLASALEEKL
VDENMVRIIASHQVLNGGIVDIFSDQRVTLVEAIEKRLISPELANMIQIDSSEFSDHRAQIEKQEGIEVCALQNEFLGKDMLIACNQTAE
MSCNKVEESERLFQVENQSAQEKVKVRVSDGEQAKKSREISLKEFGCKDQRKPRMSSDAKEFISIINPHNLKGKSLGQVSLTHPYSECDF
KLKEVARNNMGNDTNEEQEKAVTKIEIISHMKQSTSCLDSEEIRENQGEVILEVQETYCETSGKLPSEQVLQQPMNARVKSKREKREVIV
EESIRTCKPAFLSEEKLYQETAIRDEHDSHIKSQPREMTSSEKGKEADTEMGFSITFKIEESSSQVVPQGISVKHLDALTLFSSKQANEG
KVNNLSLCLTLKPEENLSREIACGAQSEPFPCMTPRPEGLHYQESDGKAQVTGPSQISKTDKSFQGTTRQETNYQDSWVTSKTKETKHQI
SSSNECKEKSYQEVSFDPARGLKLEEITVSRPDSKEVRYLEFSDRKDLHHQGSKSDDKLCGTLKSEIATQELTGEKFLEMANPNVAGLEA
GSIEDIVTQRGSRVLGSFLPEKLFKGVSQKENTGQQNAIISPTVLETSEEKTVSLTVCSAVKTEKTPQEKLRESPGSEQTPFMTAPEGKG
NGGVNPEPFRATQNVFTRQLCLEHDEKLVSYLSLLRNIEMRTKQIQPLELNLAELQDLLCQAKVLERELKDLTTLVSQELECVNQIIISQ
PQEVPAQLLKALEKDAKNLQKSLSSVSDTWNSRLLHFQNAVEIEKTKVLNQHTQLEGRLQDLRAWVGNKNLILNSKGSNSEIDVDSLNLC
LQQYEDLKQPMAERKAQLDALAFDIQFFISEHAQDLSPQQNRQMLRLLNELQRSFQDILEQTAAQVDALQGHLQQMEQEALVKTLQKQQN
TCHQQLEDLCSWVGQAERALAGHQGRTTQQDLSALQKNQSDLKDLQDDIQNRATSFATVVKDIEGFMEENQTKLSPRELTALREKLHQAK
EQYEALQEETRVAQKELEEAVTSALQQETEKSKAAKELAENKKKIDALLDWVTSVGSSGGQLLTNLPGMEQLSGASLEKGALDTTDGYMG
VNQAPEKLDKQCEMMKARHQELLSQQQNFILATQSAQAFLDQHGHNLTPEEQQMLQQKLGELKEQYSTSLAQSEAELKQVQTLQDELQKF
LQDHKEFESWLERSEKELENMHKGGSSPETLPSLLKRQGSFSEDVISHKGDLRFVTISGQKVLDMENSFKEGKEPSEIGNLVKDKLKDAT
ERYTALHSKCTRLGSHLNMLLGQYHQFQNSADSLQAWMQACEANVEKLLSDTVASDPGVLQEQLATTKQLQEELAEHQVPVEKLQKVARD
IMEIEGEPAPDHRHVQETTDSILSHFQSLSYSLAERSSLLQKAIAQSQSVQESLESLLQSIGEVEQNLEGKQVSSLSSGVIQEALATNMK
LKQDIARQKSSLEATREMVTRFMETADSTTAAVLQGKLAEVSQRFEQLCLQQQEKESSLKKLLPQAEMFEHLSGKLQQFMENKSRMLASG
NQPDQDITHFFQQIQELNLEMEDQQENLDTLEHLVTELSSCGFALDLCQHQDRVQNLRKDFTELQKTVKEREKDASSCQEQLDEFRKLVR
TFQKWLKETEGSIPPTETSMSAKELEKQIEHLKSLLDDWASKGTLVEEINCKGTSLENLIMEITAPDSQGKTGSILPSVGSSVGSVNGYH
TCKDLTEIQCDMSDVNLKYEKLGGVLHERQESLQAILNRMEEVHKEANSVLQWLESKEEVLKSMDAMSSPTKTETVKAQAESNKAFLAEL
EQNSPKIQKVKEALAGLLVTYPNSQEAENWKKIQEELNSRWERATEVTVARQRQLEESASHLACFQAAESQLRPWLMEKELMMGVLGPLS
IDPNMLNAQKQQVQFMLKEFEARRQQHEQLNEAAQGILTGPGDVSLSTSQVQKELQSINQKWVELTDKLNSRSSQIDQAIVKSTQYQELL
QDLSEKVRAVGQRLSVQSAISTQPEAVKQQLEETSEIRSDLEQLDHEVKEAQTLCDELSVLIGEQYLKDELKKRLETVALPLQGLEDLAA
DRINRLQAALASTQQFQQMFDELRTWLDDKQSQQAKNCPISAKLERLQSQLQENEEFQKSLNQHSGSYEVIVAEGESLLLSVPPGEEKRT
LQNQLVELKNHWEELSKKTADRQSRLKDCMQKAQKYQWHVEDLVPWIEDCKAKMSELRVTLDPVQLESSLLRSKAMLNEVEKRRSLLEIL
NSAADILINSSEADEDGIRDEKAGINQNMDAVTEELQAKTGSLEEMTQRLREFQESFKNIEKKVEGAKHQLEIFDALGSQACSNKNLEKL
RAQQEVLQALEPQVDYLRNFTQGLVEDAPDGSDASQLLHQAEVAQQEFLEVKQRVNSGCVMMENKLEGIGQFHCRVREMFSQLADLDDEL
DGMGAIGRDTDSLQSQIEDVRLFLNKIHVLKLDIEASEAECRHMLEEEGTLDLLGLKRELEALNKQCGKLTERGKARQEQLELTLGRVED
FYRKLKGLNDATTAAEEAEALQWVVGTEVEIINQQLADFKMFQKEQVDPLQMKLQQVNGLGQGLIQSAGKDCDVQGLEHDMEEINARWNT
LNKKVAQRIAQLQEALLHCGKFQDALEPLLSWLADTEELIANQKPPSAEYKVVKAQIQEQKLLQRLLDDRKATVDMLQAEGGRIAQSAEL
ADREKITGQLESLESRWTELLSKAAARQKQLEDILVLAKQFHETAEPISDFLSVTEKKLANSEPVGTQTAKIQQQIIRHKALEEDIENHA
TDVHQAVKIGQSLSSLTSPAEQGVLSEKIDSLQARYSEIQDRCCRKAALLDQALSNARLFGEDEVEVLNWLAEVEDKLSSVFVKDFKQDV
LHRQHADHLALNEEIVNRKKNVDQAIKNGQALLKQTTGEEVLLIQEKLDGIKTRYADITVTSSKALRTLEQARQLATKFQSTYEELTGWL
REVEEELATSGGQSPTGEQIPQFQQRQKELKKEVMEHRLVLDTVNEVSRALLELVPWRAREGLDKLVSDANEQYKLVSDTIGQRVDEIDA
AIQRSQQDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRI
GSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKL
IDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFG
IVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSL

--------------------------------------------------------------

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Fusion Gene PPI Analysis for MACF1-BRAF


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for MACF1-BRAF


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneBRAFP15056DB08881VemurafenibInhibitorSmall moleculeApproved
TgeneBRAFP15056DB08881VemurafenibInhibitorSmall moleculeApproved
TgeneBRAFP15056DB08881VemurafenibInhibitorSmall moleculeApproved
TgeneBRAFP15056DB08896RegorafenibInhibitorSmall moleculeApproved
TgeneBRAFP15056DB08896RegorafenibInhibitorSmall moleculeApproved
TgeneBRAFP15056DB08896RegorafenibInhibitorSmall moleculeApproved
TgeneBRAFP15056DB14840RipretinibInhibitorSmall moleculeApproved
TgeneBRAFP15056DB14840RipretinibInhibitorSmall moleculeApproved
TgeneBRAFP15056DB14840RipretinibInhibitorSmall moleculeApproved
TgeneBRAFP15056DB00398SorafenibInhibitorSmall moleculeApproved|Investigational
TgeneBRAFP15056DB00398SorafenibInhibitorSmall moleculeApproved|Investigational
TgeneBRAFP15056DB00398SorafenibInhibitorSmall moleculeApproved|Investigational
TgeneBRAFP15056DB08912DabrafenibAntagonist|InhibitorSmall moleculeApproved|Investigational
TgeneBRAFP15056DB08912DabrafenibAntagonist|InhibitorSmall moleculeApproved|Investigational
TgeneBRAFP15056DB08912DabrafenibAntagonist|InhibitorSmall moleculeApproved|Investigational
TgeneBRAFP15056DB11718EncorafenibInhibitorSmall moleculeApproved|Investigational
TgeneBRAFP15056DB11718EncorafenibInhibitorSmall moleculeApproved|Investigational
TgeneBRAFP15056DB11718EncorafenibInhibitorSmall moleculeApproved|Investigational
TgeneBRAFP15056DB12010FostamatinibInhibitorSmall moleculeApproved|Investigational
TgeneBRAFP15056DB12010FostamatinibInhibitorSmall moleculeApproved|Investigational
TgeneBRAFP15056DB12010FostamatinibInhibitorSmall moleculeApproved|Investigational

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Related Diseases for MACF1-BRAF


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneMACF1C0036572Seizures2GENOMICS_ENGLAND
HgeneMACF1C0266463Lissencephaly2GENOMICS_ENGLAND
HgeneMACF1C1855677Brainstem dysplasia2GENOMICS_ENGLAND
HgeneMACF1C3714756Intellectual Disability2GENOMICS_ENGLAND
TgeneC0025202melanoma24CGI;CTD_human;UNIPROT
TgeneC1275081Cardio-facio-cutaneous syndrome14CLINGEN;CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
TgeneC0009402Colorectal Carcinoma8CTD_human;UNIPROT
TgeneC0028326Noonan Syndrome8CLINGEN;CTD_human;GENOMICS_ENGLAND;ORPHANET
TgeneC0238463Papillary thyroid carcinoma8CTD_human;ORPHANET
TgeneC0040136Thyroid Neoplasm6CGI;CTD_human
TgeneC0151468Thyroid Gland Follicular Adenoma6CTD_human
TgeneC0175704LEOPARD Syndrome6CLINGEN;GENOMICS_ENGLAND
TgeneC0549473Thyroid carcinoma6CGI;CTD_human
TgeneC3150970NOONAN SYNDROME 75CTD_human;GENOMICS_ENGLAND;UNIPROT
TgeneC0009404Colorectal Neoplasms4CTD_human
TgeneC3150971LEOPARD SYNDROME 34CTD_human;GENOMICS_ENGLAND;UNIPROT
TgeneC1519086Pilomyxoid astrocytoma3ORPHANET
TgeneC0004565Melanoma, B162CTD_human
TgeneC0009075Melanoma, Cloudman S912CTD_human
TgeneC0018598Melanoma, Harding-Passey2CTD_human
TgeneC0023443Hairy Cell Leukemia2CGI;ORPHANET
TgeneC0025205Melanoma, Experimental2CTD_human
TgeneC0033578Prostatic Neoplasms2CTD_human
TgeneC0152013Adenocarcinoma of lung (disorder)2CGI;CTD_human
TgeneC0376358Malignant neoplasm of prostate2CTD_human
TgeneC0587248Costello syndrome (disorder)2CLINGEN;CTD_human
TgeneC3501843Nonmedullary Thyroid Carcinoma2CTD_human
TgeneC3501844Familial Nonmedullary Thyroid Cancer2CTD_human
TgeneC0002448Ameloblastoma1CTD_human
TgeneC0004114Astrocytoma1CTD_human
TgeneC0010276Craniopharyngioma1CTD_human;ORPHANET
TgeneC0011860Diabetes Mellitus, Non-Insulin-Dependent1CTD_human
TgeneC0017638Glioma1CGI;CTD_human
TgeneC0019621Histiocytosis, Langerhans-Cell1CGI;ORPHANET
TgeneC0022665Kidney Neoplasm1CTD_human
TgeneC0023903Liver neoplasms1CTD_human
TgeneC0024232Lymphatic Metastasis1CTD_human
TgeneC0024694Mandibular Neoplasms1CTD_human
TgeneC0027659Neoplasms, Experimental1CTD_human
TgeneC0027962Melanocytic nevus1GENOMICS_ENGLAND
TgeneC0036920Sezary Syndrome1CTD_human
TgeneC0041409Turner Syndrome, Male1CTD_human
TgeneC0079773Lymphoma, T-Cell, Cutaneous1CTD_human
TgeneC0205768Subependymal Giant Cell Astrocytoma1CTD_human
TgeneC0206686Adrenocortical carcinoma1CTD_human
TgeneC0206754Neuroendocrine Tumors1CTD_human
TgeneC0259783mixed gliomas1CTD_human
TgeneC0278875Adult Craniopharyngioma1CTD_human
TgeneC0280783Juvenile Pilocytic Astrocytoma1CTD_human
TgeneC0280785Diffuse Astrocytoma1CTD_human
TgeneC0334579Anaplastic astrocytoma1CGI;CTD_human
TgeneC0334580Protoplasmic astrocytoma1CTD_human
TgeneC0334581Gemistocytic astrocytoma1CTD_human
TgeneC0334582Fibrillary Astrocytoma1CTD_human
TgeneC0334583Pilocytic Astrocytoma1CGI;CTD_human
TgeneC0338070Childhood Cerebral Astrocytoma1CTD_human
TgeneC0345904Malignant neoplasm of liver1CTD_human
TgeneC0376407Granulomatous Slack Skin1CTD_human
TgeneC0406803Syringocystadenoma Papilliferum1GENOMICS_ENGLAND
TgeneC0431128Papillary craniopharyngioma1CTD_human
TgeneC0431129Adamantinous Craniopharyngioma1CTD_human
TgeneC0547065Mixed oligoastrocytoma1CTD_human
TgeneC0555198Malignant Glioma1CTD_human
TgeneC0596263Carcinogenesis1CTD_human
TgeneC0684249Carcinoma of lung1CGI;UNIPROT
TgeneC0740457Malignant neoplasm of kidney1CTD_human
TgeneC0750935Cerebral Astrocytoma1CTD_human
TgeneC0750936Intracranial Astrocytoma1CTD_human
TgeneC0751061Craniopharyngioma, Child1CTD_human
TgeneC0920269Microsatellite Instability1CTD_human
TgeneC1527404Female Pseudo-Turner Syndrome1CTD_human
TgeneC1704230Grade I Astrocytoma1CTD_human
TgeneC1721098Replication Error Phenotype1CTD_human
TgeneC2239176Liver carcinoma1CTD_human
TgeneC4551484Leopard Syndrome 11GENOMICS_ENGLAND
TgeneC4551602Noonan Syndrome 11CTD_human
TgeneC4721532Lymphoma, Non-Hodgkin, Familial1UNIPROT
TgeneC4733333familial non-medullary thyroid cancer1GENOMICS_ENGLAND