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![]() | Fusion Gene Summary |
![]() | Fusion Gene ORF analysis |
![]() | Fusion Genomic Features |
![]() | Fusion Protein Features |
![]() | Fusion Gene Sequence |
![]() | Fusion Gene PPI analysis |
![]() | Related Drugs |
![]() | Related Diseases |
Fusion gene:NNT-BRD4 (FusionGDB2 ID:HG23530TG23476) |
Fusion Gene Summary for NNT-BRD4 |
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Fusion gene information | Fusion gene name: NNT-BRD4 | Fusion gene ID: hg23530tg23476 | Hgene | Tgene | Gene symbol | NNT | BRD4 | Gene ID | 23530 | 23476 |
Gene name | nicotinamide nucleotide transhydrogenase | bromodomain containing 4 | |
Synonyms | GCCD4 | CAP|HUNK1|HUNKI|MCAP | |
Cytomap | ('NNT')('BRD4') 5p12 | 19p13.12 | |
Type of gene | protein-coding | protein-coding | |
Description | NAD(P) transhydrogenase, mitochondrialpyridine nucleotide transhydrogenase | bromodomain-containing protein 4chromosome-associated proteinmitotic chromosome-associated protein | |
Modification date | 20200313 | 20200329 | |
UniProtAcc | Q13423 | O60885 | |
Ensembl transtripts involved in fusion gene | ENST00000344920, ENST00000512996, ENST00000264663, | ||
Fusion gene scores | * DoF score | 4 X 3 X 4=48 | 15 X 19 X 13=3705 |
# samples | 5 | 28 | |
** MAII score | log2(5/48*10)=0.0588936890535686 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(28/3705*10)=-3.72597481024823 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: NNT [Title/Abstract] AND BRD4 [Title/Abstract] AND fusion [Title/Abstract] | ||
Most frequent breakpoint | NNT(43603396)-BRD4(15383944), # samples:1 | ||
Anticipated loss of major functional domain due to fusion event. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | BRD4 | GO:0032968 | positive regulation of transcription elongation from RNA polymerase II promoter | 19103749|23086925 |
Tgene | BRD4 | GO:0043123 | positive regulation of I-kappaB kinase/NF-kappaB signaling | 19103749 |
Tgene | BRD4 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 23086925|23317504|24360279 |
Tgene | BRD4 | GO:0050727 | regulation of inflammatory response | 19103749 |
Tgene | BRD4 | GO:1901407 | regulation of phosphorylation of RNA polymerase II C-terminal domain | 23086925 |
![]() * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChimerDB4 | STAD | TCGA-BR-A4QI-01A | NNT | chr5 | 43603396 | + | BRD4 | chr19 | 15383944 | - |
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Fusion Gene ORF analysis for NNT-BRD4 |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5UTR-5UTR | ENST00000344920 | ENST00000263377 | NNT | chr5 | 43603396 | + | BRD4 | chr19 | 15383944 | - |
5UTR-5UTR | ENST00000344920 | ENST00000360016 | NNT | chr5 | 43603396 | + | BRD4 | chr19 | 15383944 | - |
5UTR-5UTR | ENST00000344920 | ENST00000371835 | NNT | chr5 | 43603396 | + | BRD4 | chr19 | 15383944 | - |
5UTR-5UTR | ENST00000512996 | ENST00000263377 | NNT | chr5 | 43603396 | + | BRD4 | chr19 | 15383944 | - |
5UTR-5UTR | ENST00000512996 | ENST00000360016 | NNT | chr5 | 43603396 | + | BRD4 | chr19 | 15383944 | - |
5UTR-5UTR | ENST00000512996 | ENST00000371835 | NNT | chr5 | 43603396 | + | BRD4 | chr19 | 15383944 | - |
5UTR-intron | ENST00000344920 | ENST00000602230 | NNT | chr5 | 43603396 | + | BRD4 | chr19 | 15383944 | - |
5UTR-intron | ENST00000512996 | ENST00000602230 | NNT | chr5 | 43603396 | + | BRD4 | chr19 | 15383944 | - |
intron-5UTR | ENST00000264663 | ENST00000263377 | NNT | chr5 | 43603396 | + | BRD4 | chr19 | 15383944 | - |
intron-5UTR | ENST00000264663 | ENST00000360016 | NNT | chr5 | 43603396 | + | BRD4 | chr19 | 15383944 | - |
intron-5UTR | ENST00000264663 | ENST00000371835 | NNT | chr5 | 43603396 | + | BRD4 | chr19 | 15383944 | - |
intron-intron | ENST00000264663 | ENST00000602230 | NNT | chr5 | 43603396 | + | BRD4 | chr19 | 15383944 | - |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
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Fusion Genomic Features for NNT-BRD4 |
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Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
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Fusion Protein Features for NNT-BRD4 |
![]() Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:43603396/:15383944) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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Hgene | Tgene |
NNT | BRD4 |
FUNCTION: The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity). May play a role in reactive oxygen species (ROS) detoxification in the adrenal gland (PubMed:22634753). {ECO:0000250|UniProtKB:P07001, ECO:0000269|PubMed:22634753}. | FUNCTION: Chromatin reader protein that recognizes and binds acetylated histones and plays a key role in transmission of epigenetic memory across cell divisions and transcription regulation. Remains associated with acetylated chromatin throughout the entire cell cycle and provides epigenetic memory for postmitotic G1 gene transcription by preserving acetylated chromatin status and maintaining high-order chromatin structure (PubMed:23589332, PubMed:23317504, PubMed:22334664). During interphase, plays a key role in regulating the transcription of signal-inducible genes by associating with the P-TEFb complex and recruiting it to promoters. Also recruits P-TEFb complex to distal enhancers, so called anti-pause enhancers in collaboration with JMJD6. BRD4 and JMJD6 are required to form the transcriptionally active P-TEFb complex by displacing negative regulators such as HEXIM1 and 7SKsnRNA complex from P-TEFb, thereby transforming it into an active form that can then phosphorylate the C-terminal domain (CTD) of RNA polymerase II (PubMed:23589332, PubMed:19596240, PubMed:16109377, PubMed:16109376, PubMed:24360279). Promotes phosphorylation of 'Ser-2' of the C-terminal domain (CTD) of RNA polymerase II (PubMed:23086925). According to a report, directly acts as an atypical protein kinase and mediates phosphorylation of 'Ser-2' of the C-terminal domain (CTD) of RNA polymerase II; these data however need additional evidences in vivo (PubMed:22509028). In addition to acetylated histones, also recognizes and binds acetylated RELA, leading to further recruitment of the P-TEFb complex and subsequent activation of NF-kappa-B (PubMed:19103749). Also acts as a regulator of p53/TP53-mediated transcription: following phosphorylation by CK2, recruited to p53/TP53 specific target promoters (PubMed:23317504). {ECO:0000269|PubMed:16109376, ECO:0000269|PubMed:16109377, ECO:0000269|PubMed:19103749, ECO:0000269|PubMed:19596240, ECO:0000269|PubMed:22334664, ECO:0000269|PubMed:22509028, ECO:0000269|PubMed:23086925, ECO:0000269|PubMed:23317504, ECO:0000269|PubMed:23589332, ECO:0000269|PubMed:24360279}.; FUNCTION: [Isoform B]: Acts as a chromatin insulator in the DNA damage response pathway. Inhibits DNA damage response signaling by recruiting the condensin-2 complex to acetylated histones, leading to chromatin structure remodeling, insulating the region from DNA damage response by limiting spreading of histone H2AX/H2A.x phosphorylation. {ECO:0000269|PubMed:23728299}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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Fusion Gene Sequence for NNT-BRD4 |
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Fusion Gene PPI Analysis for NNT-BRD4 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for NNT-BRD4 |
![]() (DrugBank Version 5.1.8 2021-05-08) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Hgene | NNT | Q13423 | DB00157 | NADH | Small molecule | Approved|Nutraceutical | |
Hgene | NNT | Q13423 | DB09092 | Xanthinol | Cofactor | Small molecule | Approved|Withdrawn |
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Related Diseases for NNT-BRD4 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | NNT | C3553587 | GLUCOCORTICOID DEFICIENCY 4 WITH OR WITHOUT MINERALOCORTICOID DEFICIENCY | 4 | CTD_human;GENOMICS_ENGLAND;UNIPROT |
Hgene | NNT | C0342482 | X-linked Adrenal Hypoplasia | 1 | GENOMICS_ENGLAND |
Hgene | NNT | C4049650 | Familial Glucocorticoid Deficiency Type 1 | 1 | ORPHANET |
Tgene | C0017636 | Glioblastoma | 2 | CTD_human | |
Tgene | C0334588 | Giant Cell Glioblastoma | 2 | CTD_human | |
Tgene | C1621958 | Glioblastoma Multiforme | 2 | CTD_human | |
Tgene | C0002170 | Alopecia | 1 | CTD_human | |
Tgene | C0007102 | Malignant tumor of colon | 1 | CTD_human | |
Tgene | C0009375 | Colonic Neoplasms | 1 | CTD_human | |
Tgene | C0018798 | Congenital Heart Defects | 1 | GENOMICS_ENGLAND | |
Tgene | C0019193 | Hepatitis, Toxic | 1 | CTD_human | |
Tgene | C0020507 | Hyperplasia | 1 | CTD_human | |
Tgene | C0020542 | Pulmonary Hypertension | 1 | CTD_human | |
Tgene | C0025149 | Medulloblastoma | 1 | CTD_human | |
Tgene | C0025958 | Microcephaly | 1 | GENOMICS_ENGLAND | |
Tgene | C0029463 | Osteosarcoma | 1 | CTD_human | |
Tgene | C0033578 | Prostatic Neoplasms | 1 | CTD_human | |
Tgene | C0040136 | Thyroid Neoplasm | 1 | CTD_human | |
Tgene | C0085413 | Polycystic Kidney, Autosomal Dominant | 1 | CTD_human | |
Tgene | C0086873 | Pseudopelade | 1 | CTD_human | |
Tgene | C0151468 | Thyroid Gland Follicular Adenoma | 1 | CTD_human | |
Tgene | C0162311 | Androgenetic Alopecia | 1 | CTD_human | |
Tgene | C0205833 | Medullomyoblastoma | 1 | CTD_human | |
Tgene | C0263477 | Female pattern alopecia (disorder) | 1 | CTD_human | |
Tgene | C0270972 | Cornelia De Lange Syndrome | 1 | CTD_human | |
Tgene | C0278510 | Childhood Medulloblastoma | 1 | CTD_human | |
Tgene | C0278876 | Adult Medulloblastoma | 1 | CTD_human | |
Tgene | C0376358 | Malignant neoplasm of prostate | 1 | CTD_human | |
Tgene | C0549473 | Thyroid carcinoma | 1 | CTD_human | |
Tgene | C0751291 | Desmoplastic Medulloblastoma | 1 | CTD_human | |
Tgene | C0860207 | Drug-Induced Liver Disease | 1 | CTD_human | |
Tgene | C0887850 | Polycystic Kidney, Type 1 Autosomal Dominant Disease | 1 | CTD_human | |
Tgene | C1262760 | Hepatitis, Drug-Induced | 1 | CTD_human | |
Tgene | C1275668 | Melanotic medulloblastoma | 1 | CTD_human | |
Tgene | C1707291 | NUT midline carcinoma | 1 | ORPHANET | |
Tgene | C1802395 | Congenital muscular hypertrophy-cerebral syndrome | 1 | CTD_human | |
Tgene | C1853099 | Cornelia de Lange Syndrome 3 | 1 | CTD_human | |
Tgene | C2751306 | Polycystic kidney disease, type 2 | 1 | CTD_human | |
Tgene | C3658290 | Drug-Induced Acute Liver Injury | 1 | CTD_human | |
Tgene | C3714756 | Intellectual Disability | 1 | GENOMICS_ENGLAND | |
Tgene | C4025871 | Abnormality of the face | 1 | GENOMICS_ENGLAND | |
Tgene | C4083212 | Alopecia, Male Pattern | 1 | CTD_human | |
Tgene | C4277682 | Chemical and Drug Induced Liver Injury | 1 | CTD_human | |
Tgene | C4279912 | Chemically-Induced Liver Toxicity | 1 | CTD_human | |
Tgene | C4551851 | Cornelia de Lange Syndrome 1 | 1 | CTD_human |