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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:DDX58-PRSS3 (FusionGDB2 ID:HG23586TG5646)

Fusion Gene Summary for DDX58-PRSS3

check button Fusion gene summary
Fusion gene informationFusion gene name: DDX58-PRSS3
Fusion gene ID: hg23586tg5646
HgeneTgene
Gene symbol

DDX58

PRSS3

Gene ID

23586

5646

Gene nameDExD/H-box helicase 58serine protease 3
SynonymsRIG-I|RIG1|RIGI|RLR-1|SGMRT2MTG|PRSS4|T9|TRY3|TRY4
Cytomap('DDX58')('PRSS3')

9p21.1

9p13.3

Type of geneprotein-codingprotein-coding
Descriptionprobable ATP-dependent RNA helicase DDX58DEAD (Asp-Glu-Ala-Asp) box polypeptide 58DEAD box protein 58DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptideRNA helicase RIG-Iretinoic acid-inducible gene 1 proteinretinoic acid-inducible gene I proteintrypsin-3brain trypsinogenmesotrypsinmesotrypsinogenpancreatic trypsinogen IIIprotease, serine 3protease, serine, 4 (trypsin 4, brain)trypsin IIItrypsin IVtrypsinogen 4trypsinogen 5trypsinogen IV
Modification date2020032920200313
UniProtAcc

O95786

.
Ensembl transtripts involved in fusion geneENST00000379883, ENST00000379868, 
ENST00000542096, ENST00000545044, 
ENST00000379882, 
Fusion gene scores* DoF score7 X 7 X 6=29412 X 6 X 9=648
# samples 916
** MAII scorelog2(9/294*10)=-1.70781924850669
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(16/648*10)=-2.01792190799726
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: DDX58 [Title/Abstract] AND PRSS3 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointDDX58(32500802)-PRSS3(33796640), # samples:1
DDX58(32500803)-PRSS3(33796641), # samples:1
Anticipated loss of major functional domain due to fusion event.DDX58-PRSS3 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
DDX58-PRSS3 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
DDX58-PRSS3 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
DDX58-PRSS3 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneDDX58

GO:0009597

detection of virus

17079289

HgeneDDX58

GO:0010628

positive regulation of gene expression

24409285

HgeneDDX58

GO:0030334

regulation of cell migration

19122199

HgeneDDX58

GO:0032725

positive regulation of granulocyte macrophage colony-stimulating factor production

24409285

HgeneDDX58

GO:0032727

positive regulation of interferon-alpha production

19576794

HgeneDDX58

GO:0032728

positive regulation of interferon-beta production

17079289

HgeneDDX58

GO:0032755

positive regulation of interleukin-6 production

24409285

HgeneDDX58

GO:0032757

positive regulation of interleukin-8 production

24409285

HgeneDDX58

GO:0039529

RIG-I signaling pathway

28469175

HgeneDDX58

GO:0045944

positive regulation of transcription by RNA polymerase II

17079289

HgeneDDX58

GO:0051091

positive regulation of DNA-binding transcription factor activity

17079289

HgeneDDX58

GO:0051607

defense response to virus

21478870

TgenePRSS3

GO:0006508

proteolysis

6698368|11827488

TgenePRSS3

GO:0031638

zymogen activation

6698368


check buttonFusion gene breakpoints across DDX58 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across PRSS3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-CG-4444-01ADDX58chr9

32500803

-PRSS3chr9

33796641

+
ChimerDB4STADTCGA-CG-4444DDX58chr9

32500802

-PRSS3chr9

33796640

+


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Fusion Gene ORF analysis for DDX58-PRSS3

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000379883ENST00000495682DDX58chr9

32500803

-PRSS3chr9

33796641

+
5CDS-intronENST00000379883ENST00000495682DDX58chr9

32500802

-PRSS3chr9

33796640

+
5UTR-3CDSENST00000379868ENST00000342836DDX58chr9

32500803

-PRSS3chr9

33796641

+
5UTR-3CDSENST00000379868ENST00000342836DDX58chr9

32500802

-PRSS3chr9

33796640

+
5UTR-3CDSENST00000379868ENST00000361005DDX58chr9

32500803

-PRSS3chr9

33796641

+
5UTR-3CDSENST00000379868ENST00000361005DDX58chr9

32500802

-PRSS3chr9

33796640

+
5UTR-3CDSENST00000379868ENST00000379405DDX58chr9

32500803

-PRSS3chr9

33796641

+
5UTR-3CDSENST00000379868ENST00000379405DDX58chr9

32500802

-PRSS3chr9

33796640

+
5UTR-3CDSENST00000379868ENST00000429677DDX58chr9

32500803

-PRSS3chr9

33796641

+
5UTR-3CDSENST00000379868ENST00000429677DDX58chr9

32500802

-PRSS3chr9

33796640

+
5UTR-3CDSENST00000542096ENST00000342836DDX58chr9

32500803

-PRSS3chr9

33796641

+
5UTR-3CDSENST00000542096ENST00000342836DDX58chr9

32500802

-PRSS3chr9

33796640

+
5UTR-3CDSENST00000542096ENST00000361005DDX58chr9

32500803

-PRSS3chr9

33796641

+
5UTR-3CDSENST00000542096ENST00000361005DDX58chr9

32500802

-PRSS3chr9

33796640

+
5UTR-3CDSENST00000542096ENST00000379405DDX58chr9

32500803

-PRSS3chr9

33796641

+
5UTR-3CDSENST00000542096ENST00000379405DDX58chr9

32500802

-PRSS3chr9

33796640

+
5UTR-3CDSENST00000542096ENST00000429677DDX58chr9

32500803

-PRSS3chr9

33796641

+
5UTR-3CDSENST00000542096ENST00000429677DDX58chr9

32500802

-PRSS3chr9

33796640

+
5UTR-3CDSENST00000545044ENST00000342836DDX58chr9

32500803

-PRSS3chr9

33796641

+
5UTR-3CDSENST00000545044ENST00000342836DDX58chr9

32500802

-PRSS3chr9

33796640

+
5UTR-3CDSENST00000545044ENST00000361005DDX58chr9

32500803

-PRSS3chr9

33796641

+
5UTR-3CDSENST00000545044ENST00000361005DDX58chr9

32500802

-PRSS3chr9

33796640

+
5UTR-3CDSENST00000545044ENST00000379405DDX58chr9

32500803

-PRSS3chr9

33796641

+
5UTR-3CDSENST00000545044ENST00000379405DDX58chr9

32500802

-PRSS3chr9

33796640

+
5UTR-3CDSENST00000545044ENST00000429677DDX58chr9

32500803

-PRSS3chr9

33796641

+
5UTR-3CDSENST00000545044ENST00000429677DDX58chr9

32500802

-PRSS3chr9

33796640

+
5UTR-intronENST00000379868ENST00000495682DDX58chr9

32500803

-PRSS3chr9

33796641

+
5UTR-intronENST00000379868ENST00000495682DDX58chr9

32500802

-PRSS3chr9

33796640

+
5UTR-intronENST00000542096ENST00000495682DDX58chr9

32500803

-PRSS3chr9

33796641

+
5UTR-intronENST00000542096ENST00000495682DDX58chr9

32500802

-PRSS3chr9

33796640

+
5UTR-intronENST00000545044ENST00000495682DDX58chr9

32500803

-PRSS3chr9

33796641

+
5UTR-intronENST00000545044ENST00000495682DDX58chr9

32500802

-PRSS3chr9

33796640

+
In-frameENST00000379883ENST00000342836DDX58chr9

32500803

-PRSS3chr9

33796641

+
In-frameENST00000379883ENST00000342836DDX58chr9

32500802

-PRSS3chr9

33796640

+
In-frameENST00000379883ENST00000361005DDX58chr9

32500803

-PRSS3chr9

33796641

+
In-frameENST00000379883ENST00000361005DDX58chr9

32500802

-PRSS3chr9

33796640

+
In-frameENST00000379883ENST00000379405DDX58chr9

32500803

-PRSS3chr9

33796641

+
In-frameENST00000379883ENST00000379405DDX58chr9

32500802

-PRSS3chr9

33796640

+
In-frameENST00000379883ENST00000429677DDX58chr9

32500803

-PRSS3chr9

33796641

+
In-frameENST00000379883ENST00000429677DDX58chr9

32500802

-PRSS3chr9

33796640

+
intron-3CDSENST00000379882ENST00000342836DDX58chr9

32500803

-PRSS3chr9

33796641

+
intron-3CDSENST00000379882ENST00000342836DDX58chr9

32500802

-PRSS3chr9

33796640

+
intron-3CDSENST00000379882ENST00000361005DDX58chr9

32500803

-PRSS3chr9

33796641

+
intron-3CDSENST00000379882ENST00000361005DDX58chr9

32500802

-PRSS3chr9

33796640

+
intron-3CDSENST00000379882ENST00000379405DDX58chr9

32500803

-PRSS3chr9

33796641

+
intron-3CDSENST00000379882ENST00000379405DDX58chr9

32500802

-PRSS3chr9

33796640

+
intron-3CDSENST00000379882ENST00000429677DDX58chr9

32500803

-PRSS3chr9

33796641

+
intron-3CDSENST00000379882ENST00000429677DDX58chr9

32500802

-PRSS3chr9

33796640

+
intron-intronENST00000379882ENST00000495682DDX58chr9

32500803

-PRSS3chr9

33796641

+
intron-intronENST00000379882ENST00000495682DDX58chr9

32500802

-PRSS3chr9

33796640

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000379883DDX58chr932500802-ENST00000361005PRSS3chr933796640+11543991401102320
ENST00000379883DDX58chr932500802-ENST00000342836PRSS3chr933796640+11553991401102320
ENST00000379883DDX58chr932500802-ENST00000429677PRSS3chr933796640+11533991401102320
ENST00000379883DDX58chr932500802-ENST00000379405PRSS3chr933796640+11543991401102320
ENST00000379883DDX58chr932500803-ENST00000361005PRSS3chr933796641+11543991401102320
ENST00000379883DDX58chr932500803-ENST00000342836PRSS3chr933796641+11553991401102320
ENST00000379883DDX58chr932500803-ENST00000429677PRSS3chr933796641+11533991401102320
ENST00000379883DDX58chr932500803-ENST00000379405PRSS3chr933796641+11543991401102320

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000379883ENST00000361005DDX58chr932500802-PRSS3chr933796640+0.008922510.99107754
ENST00000379883ENST00000342836DDX58chr932500802-PRSS3chr933796640+0.0088207260.9911793
ENST00000379883ENST00000429677DDX58chr932500802-PRSS3chr933796640+0.0089103450.9910897
ENST00000379883ENST00000379405DDX58chr932500802-PRSS3chr933796640+0.008922510.99107754
ENST00000379883ENST00000361005DDX58chr932500803-PRSS3chr933796641+0.008922510.99107754
ENST00000379883ENST00000342836DDX58chr932500803-PRSS3chr933796641+0.0088207260.9911793
ENST00000379883ENST00000429677DDX58chr932500803-PRSS3chr933796641+0.0089103450.9910897
ENST00000379883ENST00000379405DDX58chr932500803-PRSS3chr933796641+0.008922510.99107754

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Fusion Genomic Features for DDX58-PRSS3


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
DDX58chr932500802-PRSS3chr933796640+4.63E-101
DDX58chr932500802-PRSS3chr933796640+4.63E-101
DDX58chr932500802-PRSS3chr933796640+4.63E-101
DDX58chr932500802-PRSS3chr933796640+4.63E-101

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for DDX58-PRSS3


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr9:32500802/chr9:33796640)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DDX58

O95786

.
FUNCTION: Innate immune receptor that senses cytoplasmic viral nucleic acids and activates a downstream signaling cascade leading to the production of type I interferons and proinflammatory cytokines. Forms a ribonucleoprotein complex with viral RNAs on which it homooligomerizes to form filaments. The homooligomerization allows the recruitment of RNF135 an E3 ubiquitin-protein ligase that activates and amplifies the RIG-I-mediated antiviral signaling in an RNA length-dependent manner through ubiquitination-dependent and -independent mechanisms (PubMed:28469175, PubMed:31006531). Upon activation, associates with mitochondria antiviral signaling protein (MAVS/IPS1) that activates the IKK-related kinases TBK1 and IKBKE which in turn phosphorylate the interferon regulatory factors IRF3 and IRF7, activating transcription of antiviral immunological genes including the IFN-alpha and IFN-beta interferons (PubMed:28469175, PubMed:31006531). Ligands include 5'-triphosphorylated ssRNAs and dsRNAs but also short dsRNAs (<1 kb in length). In addition to the 5'-triphosphate moiety, blunt-end base pairing at the 5'-end of the RNA is very essential. Overhangs at the non-triphosphorylated end of the dsRNA RNA have no major impact on its activity. A 3'overhang at the 5'triphosphate end decreases and any 5'overhang at the 5' triphosphate end abolishes its activity. Detects both positive and negative strand RNA viruses including members of the families Paramyxoviridae: Human respiratory syncytial virus and measles virus (MeV), Rhabdoviridae: vesicular stomatitis virus (VSV), Orthomyxoviridae: influenza A and B virus, Flaviviridae: Japanese encephalitis virus (JEV), hepatitis C virus (HCV), dengue virus (DENV) and west Nile virus (WNV). It also detects rotaviruses and reoviruses. Also involved in antiviral signaling in response to viruses containing a dsDNA genome such as Epstein-Barr virus (EBV). Detects dsRNA produced from non-self dsDNA by RNA polymerase III, such as Epstein-Barr virus-encoded RNAs (EBERs). May play important roles in granulocyte production and differentiation, bacterial phagocytosis and in the regulation of cell migration. {ECO:0000269|PubMed:15208624, ECO:0000269|PubMed:15708988, ECO:0000269|PubMed:16125763, ECO:0000269|PubMed:16127453, ECO:0000269|PubMed:16153868, ECO:0000269|PubMed:17190814, ECO:0000269|PubMed:18636086, ECO:0000269|PubMed:19122199, ECO:0000269|PubMed:19211564, ECO:0000269|PubMed:19576794, ECO:0000269|PubMed:19609254, ECO:0000269|PubMed:19631370, ECO:0000269|PubMed:21742966, ECO:0000269|PubMed:28469175, ECO:0000269|PubMed:29117565, ECO:0000269|PubMed:31006531}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgenePRSS3chr9:32500802chr9:33796640ENST000003428361681_30127262.0DomainPeptidase S1
TgenePRSS3chr9:32500802chr9:33796640ENST000003610050581_30170305.0DomainPeptidase S1
TgenePRSS3chr9:32500802chr9:33796640ENST000003794050581_30113248.0DomainPeptidase S1
TgenePRSS3chr9:32500803chr9:33796641ENST000003428361681_30127262.0DomainPeptidase S1
TgenePRSS3chr9:32500803chr9:33796641ENST000003610050581_30170305.0DomainPeptidase S1
TgenePRSS3chr9:32500803chr9:33796641ENST000003794050581_30113248.0DomainPeptidase S1

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneDDX58chr9:32500802chr9:33796640ENST00000379882-1171_870881.0DomainNote=CARD 1
HgeneDDX58chr9:32500802chr9:33796640ENST00000379882-117251_4300881.0DomainHelicase ATP-binding
HgeneDDX58chr9:32500802chr9:33796640ENST00000379882-117610_7760881.0DomainHelicase C-terminal
HgeneDDX58chr9:32500802chr9:33796640ENST00000379882-117794_9250881.0DomainRLR CTR
HgeneDDX58chr9:32500802chr9:33796640ENST00000379882-11792_1720881.0DomainNote=CARD 2
HgeneDDX58chr9:32500802chr9:33796640ENST00000379883-2181_8780926.0DomainNote=CARD 1
HgeneDDX58chr9:32500802chr9:33796640ENST00000379883-218251_43080926.0DomainHelicase ATP-binding
HgeneDDX58chr9:32500802chr9:33796640ENST00000379883-218610_77680926.0DomainHelicase C-terminal
HgeneDDX58chr9:32500802chr9:33796640ENST00000379883-218794_92580926.0DomainRLR CTR
HgeneDDX58chr9:32500802chr9:33796640ENST00000379883-21892_17280926.0DomainNote=CARD 2
HgeneDDX58chr9:32500803chr9:33796641ENST00000379882-1171_870881.0DomainNote=CARD 1
HgeneDDX58chr9:32500803chr9:33796641ENST00000379882-117251_4300881.0DomainHelicase ATP-binding
HgeneDDX58chr9:32500803chr9:33796641ENST00000379882-117610_7760881.0DomainHelicase C-terminal
HgeneDDX58chr9:32500803chr9:33796641ENST00000379882-117794_9250881.0DomainRLR CTR
HgeneDDX58chr9:32500803chr9:33796641ENST00000379882-11792_1720881.0DomainNote=CARD 2
HgeneDDX58chr9:32500803chr9:33796641ENST00000379883-2181_8780926.0DomainNote=CARD 1
HgeneDDX58chr9:32500803chr9:33796641ENST00000379883-218251_43080926.0DomainHelicase ATP-binding
HgeneDDX58chr9:32500803chr9:33796641ENST00000379883-218610_77680926.0DomainHelicase C-terminal
HgeneDDX58chr9:32500803chr9:33796641ENST00000379883-218794_92580926.0DomainRLR CTR
HgeneDDX58chr9:32500803chr9:33796641ENST00000379883-21892_17280926.0DomainNote=CARD 2
HgeneDDX58chr9:32500802chr9:33796640ENST00000379882-117372_3750881.0MotifNote=DECH box
HgeneDDX58chr9:32500802chr9:33796640ENST00000379883-218372_37580926.0MotifNote=DECH box
HgeneDDX58chr9:32500803chr9:33796641ENST00000379882-117372_3750881.0MotifNote=DECH box
HgeneDDX58chr9:32500803chr9:33796641ENST00000379883-218372_37580926.0MotifNote=DECH box
HgeneDDX58chr9:32500802chr9:33796640ENST00000379882-117264_2710881.0Nucleotide bindingATP
HgeneDDX58chr9:32500802chr9:33796640ENST00000379883-218264_27180926.0Nucleotide bindingATP
HgeneDDX58chr9:32500803chr9:33796641ENST00000379882-117264_2710881.0Nucleotide bindingATP
HgeneDDX58chr9:32500803chr9:33796641ENST00000379883-218264_27180926.0Nucleotide bindingATP


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Fusion Gene Sequence for DDX58-PRSS3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>22060_22060_1_DDX58-PRSS3_DDX58_chr9_32500802_ENST00000379883_PRSS3_chr9_33796640_ENST00000342836_length(transcript)=1155nt_BP=399nt
TAGTTATTAAAGTTCCTATGCAGCTCCGCCTCGCGTCCGGCCTCATTTCCTCGGAAAATCCCTGCTTTCCCCGCTCGCCACGCCCTCCTC
CTACCCGGCTTTAAAGCTAGTGAGGCACAGCCTGCGGGGAACGTAGCTAGCTGCAAGCAGAGGCCGGCATGACCACCGAGCAGCGACGCA
GCCTGCAAGCCTTCCAGGATTATATCCGGAAGACCCTGGACCCTACCTACATCCTGAGCTACATGGCCCCCTGGTTTAGGGAGGAAGAGG
TGCAGTATATTCAGGCTGAGAAAAACAACAAGGGCCCAATGGAGGCTGCCACACTTTTTCTCAAGTTCCTGTTGGAGCTCCAGGAGGAAG
GCTGGTTCCGTGGCTTTTTGGATGCCCTAGACCATGCAGTTGCTGTCCCCTTTGACGATGATGACAAGATTGTTGGGGGCTACACCTGTG
AGGAGAATTCTCTCCCCTACCAGGTGTCCCTGAATTCTGGCTCCCACTTCTGCGGTGGCTCCCTCATCAGCGAACAGTGGGTGGTATCAG
CAGCTCACTGCTACAAGACCCGCATCCAGGTGAGACTGGGAGAGCACAACATCAAAGTCCTGGAGGGGAATGAGCAGTTCATCAATGCGG
CCAAGATCATCCGCCACCCTAAATACAACAGGGACACTCTGGACAATGACATCATGCTGATCAAACTCTCCTCACCTGCCGTCATCAATG
CCCGCGTGTCCACCATCTCTCTGCCCACCACCCCTCCAGCTGCTGGCACTGAGTGCCTCATCTCCGGCTGGGGCAACACTCTGAGCTTTG
GTGCTGACTACCCAGACGAGCTGAAGTGCCTGGATGCTCCGGTGCTGACCCAGGCTGAGTGTAAAGCCTCCTACCCTGGAAAGATTACCA
ACAGCATGTTCTGTGTGGGCTTCCTTGAGGGAGGCAAGGATTCCTGCCAGCGTGACTCTGGTGGCCCTGTGGTCTGCAACGGACAGCTCC
AAGGAGTTGTCTCCTGGGGCCATGGCTGTGCCTGGAAGAACAGGCCTGGAGTCTACACCAAGGTCTACAACTATGTGGACTGGATTAAGG

>22060_22060_1_DDX58-PRSS3_DDX58_chr9_32500802_ENST00000379883_PRSS3_chr9_33796640_ENST00000342836_length(amino acids)=320AA_BP=86
MQAEAGMTTEQRRSLQAFQDYIRKTLDPTYILSYMAPWFREEEVQYIQAEKNNKGPMEAATLFLKFLLELQEEGWFRGFLDALDHAVAVP
FDDDDKIVGGYTCEENSLPYQVSLNSGSHFCGGSLISEQWVVSAAHCYKTRIQVRLGEHNIKVLEGNEQFINAAKIIRHPKYNRDTLDND
IMLIKLSSPAVINARVSTISLPTTPPAAGTECLISGWGNTLSFGADYPDELKCLDAPVLTQAECKASYPGKITNSMFCVGFLEGGKDSCQ

--------------------------------------------------------------
>22060_22060_2_DDX58-PRSS3_DDX58_chr9_32500802_ENST00000379883_PRSS3_chr9_33796640_ENST00000361005_length(transcript)=1154nt_BP=399nt
TAGTTATTAAAGTTCCTATGCAGCTCCGCCTCGCGTCCGGCCTCATTTCCTCGGAAAATCCCTGCTTTCCCCGCTCGCCACGCCCTCCTC
CTACCCGGCTTTAAAGCTAGTGAGGCACAGCCTGCGGGGAACGTAGCTAGCTGCAAGCAGAGGCCGGCATGACCACCGAGCAGCGACGCA
GCCTGCAAGCCTTCCAGGATTATATCCGGAAGACCCTGGACCCTACCTACATCCTGAGCTACATGGCCCCCTGGTTTAGGGAGGAAGAGG
TGCAGTATATTCAGGCTGAGAAAAACAACAAGGGCCCAATGGAGGCTGCCACACTTTTTCTCAAGTTCCTGTTGGAGCTCCAGGAGGAAG
GCTGGTTCCGTGGCTTTTTGGATGCCCTAGACCATGCAGTTGCTGTCCCCTTTGACGATGATGACAAGATTGTTGGGGGCTACACCTGTG
AGGAGAATTCTCTCCCCTACCAGGTGTCCCTGAATTCTGGCTCCCACTTCTGCGGTGGCTCCCTCATCAGCGAACAGTGGGTGGTATCAG
CAGCTCACTGCTACAAGACCCGCATCCAGGTGAGACTGGGAGAGCACAACATCAAAGTCCTGGAGGGGAATGAGCAGTTCATCAATGCGG
CCAAGATCATCCGCCACCCTAAATACAACAGGGACACTCTGGACAATGACATCATGCTGATCAAACTCTCCTCACCTGCCGTCATCAATG
CCCGCGTGTCCACCATCTCTCTGCCCACCACCCCTCCAGCTGCTGGCACTGAGTGCCTCATCTCCGGCTGGGGCAACACTCTGAGCTTTG
GTGCTGACTACCCAGACGAGCTGAAGTGCCTGGATGCTCCGGTGCTGACCCAGGCTGAGTGTAAAGCCTCCTACCCTGGAAAGATTACCA
ACAGCATGTTCTGTGTGGGCTTCCTTGAGGGAGGCAAGGATTCCTGCCAGCGTGACTCTGGTGGCCCTGTGGTCTGCAACGGACAGCTCC
AAGGAGTTGTCTCCTGGGGCCATGGCTGTGCCTGGAAGAACAGGCCTGGAGTCTACACCAAGGTCTACAACTATGTGGACTGGATTAAGG

>22060_22060_2_DDX58-PRSS3_DDX58_chr9_32500802_ENST00000379883_PRSS3_chr9_33796640_ENST00000361005_length(amino acids)=320AA_BP=86
MQAEAGMTTEQRRSLQAFQDYIRKTLDPTYILSYMAPWFREEEVQYIQAEKNNKGPMEAATLFLKFLLELQEEGWFRGFLDALDHAVAVP
FDDDDKIVGGYTCEENSLPYQVSLNSGSHFCGGSLISEQWVVSAAHCYKTRIQVRLGEHNIKVLEGNEQFINAAKIIRHPKYNRDTLDND
IMLIKLSSPAVINARVSTISLPTTPPAAGTECLISGWGNTLSFGADYPDELKCLDAPVLTQAECKASYPGKITNSMFCVGFLEGGKDSCQ

--------------------------------------------------------------
>22060_22060_3_DDX58-PRSS3_DDX58_chr9_32500802_ENST00000379883_PRSS3_chr9_33796640_ENST00000379405_length(transcript)=1154nt_BP=399nt
TAGTTATTAAAGTTCCTATGCAGCTCCGCCTCGCGTCCGGCCTCATTTCCTCGGAAAATCCCTGCTTTCCCCGCTCGCCACGCCCTCCTC
CTACCCGGCTTTAAAGCTAGTGAGGCACAGCCTGCGGGGAACGTAGCTAGCTGCAAGCAGAGGCCGGCATGACCACCGAGCAGCGACGCA
GCCTGCAAGCCTTCCAGGATTATATCCGGAAGACCCTGGACCCTACCTACATCCTGAGCTACATGGCCCCCTGGTTTAGGGAGGAAGAGG
TGCAGTATATTCAGGCTGAGAAAAACAACAAGGGCCCAATGGAGGCTGCCACACTTTTTCTCAAGTTCCTGTTGGAGCTCCAGGAGGAAG
GCTGGTTCCGTGGCTTTTTGGATGCCCTAGACCATGCAGTTGCTGTCCCCTTTGACGATGATGACAAGATTGTTGGGGGCTACACCTGTG
AGGAGAATTCTCTCCCCTACCAGGTGTCCCTGAATTCTGGCTCCCACTTCTGCGGTGGCTCCCTCATCAGCGAACAGTGGGTGGTATCAG
CAGCTCACTGCTACAAGACCCGCATCCAGGTGAGACTGGGAGAGCACAACATCAAAGTCCTGGAGGGGAATGAGCAGTTCATCAATGCGG
CCAAGATCATCCGCCACCCTAAATACAACAGGGACACTCTGGACAATGACATCATGCTGATCAAACTCTCCTCACCTGCCGTCATCAATG
CCCGCGTGTCCACCATCTCTCTGCCCACCACCCCTCCAGCTGCTGGCACTGAGTGCCTCATCTCCGGCTGGGGCAACACTCTGAGCTTTG
GTGCTGACTACCCAGACGAGCTGAAGTGCCTGGATGCTCCGGTGCTGACCCAGGCTGAGTGTAAAGCCTCCTACCCTGGAAAGATTACCA
ACAGCATGTTCTGTGTGGGCTTCCTTGAGGGAGGCAAGGATTCCTGCCAGCGTGACTCTGGTGGCCCTGTGGTCTGCAACGGACAGCTCC
AAGGAGTTGTCTCCTGGGGCCATGGCTGTGCCTGGAAGAACAGGCCTGGAGTCTACACCAAGGTCTACAACTATGTGGACTGGATTAAGG

>22060_22060_3_DDX58-PRSS3_DDX58_chr9_32500802_ENST00000379883_PRSS3_chr9_33796640_ENST00000379405_length(amino acids)=320AA_BP=86
MQAEAGMTTEQRRSLQAFQDYIRKTLDPTYILSYMAPWFREEEVQYIQAEKNNKGPMEAATLFLKFLLELQEEGWFRGFLDALDHAVAVP
FDDDDKIVGGYTCEENSLPYQVSLNSGSHFCGGSLISEQWVVSAAHCYKTRIQVRLGEHNIKVLEGNEQFINAAKIIRHPKYNRDTLDND
IMLIKLSSPAVINARVSTISLPTTPPAAGTECLISGWGNTLSFGADYPDELKCLDAPVLTQAECKASYPGKITNSMFCVGFLEGGKDSCQ

--------------------------------------------------------------
>22060_22060_4_DDX58-PRSS3_DDX58_chr9_32500802_ENST00000379883_PRSS3_chr9_33796640_ENST00000429677_length(transcript)=1153nt_BP=399nt
TAGTTATTAAAGTTCCTATGCAGCTCCGCCTCGCGTCCGGCCTCATTTCCTCGGAAAATCCCTGCTTTCCCCGCTCGCCACGCCCTCCTC
CTACCCGGCTTTAAAGCTAGTGAGGCACAGCCTGCGGGGAACGTAGCTAGCTGCAAGCAGAGGCCGGCATGACCACCGAGCAGCGACGCA
GCCTGCAAGCCTTCCAGGATTATATCCGGAAGACCCTGGACCCTACCTACATCCTGAGCTACATGGCCCCCTGGTTTAGGGAGGAAGAGG
TGCAGTATATTCAGGCTGAGAAAAACAACAAGGGCCCAATGGAGGCTGCCACACTTTTTCTCAAGTTCCTGTTGGAGCTCCAGGAGGAAG
GCTGGTTCCGTGGCTTTTTGGATGCCCTAGACCATGCAGTTGCTGTCCCCTTTGACGATGATGACAAGATTGTTGGGGGCTACACCTGTG
AGGAGAATTCTCTCCCCTACCAGGTGTCCCTGAATTCTGGCTCCCACTTCTGCGGTGGCTCCCTCATCAGCGAACAGTGGGTGGTATCAG
CAGCTCACTGCTACAAGACCCGCATCCAGGTGAGACTGGGAGAGCACAACATCAAAGTCCTGGAGGGGAATGAGCAGTTCATCAATGCGG
CCAAGATCATCCGCCACCCTAAATACAACAGGGACACTCTGGACAATGACATCATGCTGATCAAACTCTCCTCACCTGCCGTCATCAATG
CCCGCGTGTCCACCATCTCTCTGCCCACCACCCCTCCAGCTGCTGGCACTGAGTGCCTCATCTCCGGCTGGGGCAACACTCTGAGCTTTG
GTGCTGACTACCCAGACGAGCTGAAGTGCCTGGATGCTCCGGTGCTGACCCAGGCTGAGTGTAAAGCCTCCTACCCTGGAAAGATTACCA
ACAGCATGTTCTGTGTGGGCTTCCTTGAGGGAGGCAAGGATTCCTGCCAGCGTGACTCTGGTGGCCCTGTGGTCTGCAACGGACAGCTCC
AAGGAGTTGTCTCCTGGGGCCATGGCTGTGCCTGGAAGAACAGGCCTGGAGTCTACACCAAGGTCTACAACTATGTGGACTGGATTAAGG

>22060_22060_4_DDX58-PRSS3_DDX58_chr9_32500802_ENST00000379883_PRSS3_chr9_33796640_ENST00000429677_length(amino acids)=320AA_BP=86
MQAEAGMTTEQRRSLQAFQDYIRKTLDPTYILSYMAPWFREEEVQYIQAEKNNKGPMEAATLFLKFLLELQEEGWFRGFLDALDHAVAVP
FDDDDKIVGGYTCEENSLPYQVSLNSGSHFCGGSLISEQWVVSAAHCYKTRIQVRLGEHNIKVLEGNEQFINAAKIIRHPKYNRDTLDND
IMLIKLSSPAVINARVSTISLPTTPPAAGTECLISGWGNTLSFGADYPDELKCLDAPVLTQAECKASYPGKITNSMFCVGFLEGGKDSCQ

--------------------------------------------------------------
>22060_22060_5_DDX58-PRSS3_DDX58_chr9_32500803_ENST00000379883_PRSS3_chr9_33796641_ENST00000342836_length(transcript)=1155nt_BP=399nt
TAGTTATTAAAGTTCCTATGCAGCTCCGCCTCGCGTCCGGCCTCATTTCCTCGGAAAATCCCTGCTTTCCCCGCTCGCCACGCCCTCCTC
CTACCCGGCTTTAAAGCTAGTGAGGCACAGCCTGCGGGGAACGTAGCTAGCTGCAAGCAGAGGCCGGCATGACCACCGAGCAGCGACGCA
GCCTGCAAGCCTTCCAGGATTATATCCGGAAGACCCTGGACCCTACCTACATCCTGAGCTACATGGCCCCCTGGTTTAGGGAGGAAGAGG
TGCAGTATATTCAGGCTGAGAAAAACAACAAGGGCCCAATGGAGGCTGCCACACTTTTTCTCAAGTTCCTGTTGGAGCTCCAGGAGGAAG
GCTGGTTCCGTGGCTTTTTGGATGCCCTAGACCATGCAGTTGCTGTCCCCTTTGACGATGATGACAAGATTGTTGGGGGCTACACCTGTG
AGGAGAATTCTCTCCCCTACCAGGTGTCCCTGAATTCTGGCTCCCACTTCTGCGGTGGCTCCCTCATCAGCGAACAGTGGGTGGTATCAG
CAGCTCACTGCTACAAGACCCGCATCCAGGTGAGACTGGGAGAGCACAACATCAAAGTCCTGGAGGGGAATGAGCAGTTCATCAATGCGG
CCAAGATCATCCGCCACCCTAAATACAACAGGGACACTCTGGACAATGACATCATGCTGATCAAACTCTCCTCACCTGCCGTCATCAATG
CCCGCGTGTCCACCATCTCTCTGCCCACCACCCCTCCAGCTGCTGGCACTGAGTGCCTCATCTCCGGCTGGGGCAACACTCTGAGCTTTG
GTGCTGACTACCCAGACGAGCTGAAGTGCCTGGATGCTCCGGTGCTGACCCAGGCTGAGTGTAAAGCCTCCTACCCTGGAAAGATTACCA
ACAGCATGTTCTGTGTGGGCTTCCTTGAGGGAGGCAAGGATTCCTGCCAGCGTGACTCTGGTGGCCCTGTGGTCTGCAACGGACAGCTCC
AAGGAGTTGTCTCCTGGGGCCATGGCTGTGCCTGGAAGAACAGGCCTGGAGTCTACACCAAGGTCTACAACTATGTGGACTGGATTAAGG

>22060_22060_5_DDX58-PRSS3_DDX58_chr9_32500803_ENST00000379883_PRSS3_chr9_33796641_ENST00000342836_length(amino acids)=320AA_BP=86
MQAEAGMTTEQRRSLQAFQDYIRKTLDPTYILSYMAPWFREEEVQYIQAEKNNKGPMEAATLFLKFLLELQEEGWFRGFLDALDHAVAVP
FDDDDKIVGGYTCEENSLPYQVSLNSGSHFCGGSLISEQWVVSAAHCYKTRIQVRLGEHNIKVLEGNEQFINAAKIIRHPKYNRDTLDND
IMLIKLSSPAVINARVSTISLPTTPPAAGTECLISGWGNTLSFGADYPDELKCLDAPVLTQAECKASYPGKITNSMFCVGFLEGGKDSCQ

--------------------------------------------------------------
>22060_22060_6_DDX58-PRSS3_DDX58_chr9_32500803_ENST00000379883_PRSS3_chr9_33796641_ENST00000361005_length(transcript)=1154nt_BP=399nt
TAGTTATTAAAGTTCCTATGCAGCTCCGCCTCGCGTCCGGCCTCATTTCCTCGGAAAATCCCTGCTTTCCCCGCTCGCCACGCCCTCCTC
CTACCCGGCTTTAAAGCTAGTGAGGCACAGCCTGCGGGGAACGTAGCTAGCTGCAAGCAGAGGCCGGCATGACCACCGAGCAGCGACGCA
GCCTGCAAGCCTTCCAGGATTATATCCGGAAGACCCTGGACCCTACCTACATCCTGAGCTACATGGCCCCCTGGTTTAGGGAGGAAGAGG
TGCAGTATATTCAGGCTGAGAAAAACAACAAGGGCCCAATGGAGGCTGCCACACTTTTTCTCAAGTTCCTGTTGGAGCTCCAGGAGGAAG
GCTGGTTCCGTGGCTTTTTGGATGCCCTAGACCATGCAGTTGCTGTCCCCTTTGACGATGATGACAAGATTGTTGGGGGCTACACCTGTG
AGGAGAATTCTCTCCCCTACCAGGTGTCCCTGAATTCTGGCTCCCACTTCTGCGGTGGCTCCCTCATCAGCGAACAGTGGGTGGTATCAG
CAGCTCACTGCTACAAGACCCGCATCCAGGTGAGACTGGGAGAGCACAACATCAAAGTCCTGGAGGGGAATGAGCAGTTCATCAATGCGG
CCAAGATCATCCGCCACCCTAAATACAACAGGGACACTCTGGACAATGACATCATGCTGATCAAACTCTCCTCACCTGCCGTCATCAATG
CCCGCGTGTCCACCATCTCTCTGCCCACCACCCCTCCAGCTGCTGGCACTGAGTGCCTCATCTCCGGCTGGGGCAACACTCTGAGCTTTG
GTGCTGACTACCCAGACGAGCTGAAGTGCCTGGATGCTCCGGTGCTGACCCAGGCTGAGTGTAAAGCCTCCTACCCTGGAAAGATTACCA
ACAGCATGTTCTGTGTGGGCTTCCTTGAGGGAGGCAAGGATTCCTGCCAGCGTGACTCTGGTGGCCCTGTGGTCTGCAACGGACAGCTCC
AAGGAGTTGTCTCCTGGGGCCATGGCTGTGCCTGGAAGAACAGGCCTGGAGTCTACACCAAGGTCTACAACTATGTGGACTGGATTAAGG

>22060_22060_6_DDX58-PRSS3_DDX58_chr9_32500803_ENST00000379883_PRSS3_chr9_33796641_ENST00000361005_length(amino acids)=320AA_BP=86
MQAEAGMTTEQRRSLQAFQDYIRKTLDPTYILSYMAPWFREEEVQYIQAEKNNKGPMEAATLFLKFLLELQEEGWFRGFLDALDHAVAVP
FDDDDKIVGGYTCEENSLPYQVSLNSGSHFCGGSLISEQWVVSAAHCYKTRIQVRLGEHNIKVLEGNEQFINAAKIIRHPKYNRDTLDND
IMLIKLSSPAVINARVSTISLPTTPPAAGTECLISGWGNTLSFGADYPDELKCLDAPVLTQAECKASYPGKITNSMFCVGFLEGGKDSCQ

--------------------------------------------------------------
>22060_22060_7_DDX58-PRSS3_DDX58_chr9_32500803_ENST00000379883_PRSS3_chr9_33796641_ENST00000379405_length(transcript)=1154nt_BP=399nt
TAGTTATTAAAGTTCCTATGCAGCTCCGCCTCGCGTCCGGCCTCATTTCCTCGGAAAATCCCTGCTTTCCCCGCTCGCCACGCCCTCCTC
CTACCCGGCTTTAAAGCTAGTGAGGCACAGCCTGCGGGGAACGTAGCTAGCTGCAAGCAGAGGCCGGCATGACCACCGAGCAGCGACGCA
GCCTGCAAGCCTTCCAGGATTATATCCGGAAGACCCTGGACCCTACCTACATCCTGAGCTACATGGCCCCCTGGTTTAGGGAGGAAGAGG
TGCAGTATATTCAGGCTGAGAAAAACAACAAGGGCCCAATGGAGGCTGCCACACTTTTTCTCAAGTTCCTGTTGGAGCTCCAGGAGGAAG
GCTGGTTCCGTGGCTTTTTGGATGCCCTAGACCATGCAGTTGCTGTCCCCTTTGACGATGATGACAAGATTGTTGGGGGCTACACCTGTG
AGGAGAATTCTCTCCCCTACCAGGTGTCCCTGAATTCTGGCTCCCACTTCTGCGGTGGCTCCCTCATCAGCGAACAGTGGGTGGTATCAG
CAGCTCACTGCTACAAGACCCGCATCCAGGTGAGACTGGGAGAGCACAACATCAAAGTCCTGGAGGGGAATGAGCAGTTCATCAATGCGG
CCAAGATCATCCGCCACCCTAAATACAACAGGGACACTCTGGACAATGACATCATGCTGATCAAACTCTCCTCACCTGCCGTCATCAATG
CCCGCGTGTCCACCATCTCTCTGCCCACCACCCCTCCAGCTGCTGGCACTGAGTGCCTCATCTCCGGCTGGGGCAACACTCTGAGCTTTG
GTGCTGACTACCCAGACGAGCTGAAGTGCCTGGATGCTCCGGTGCTGACCCAGGCTGAGTGTAAAGCCTCCTACCCTGGAAAGATTACCA
ACAGCATGTTCTGTGTGGGCTTCCTTGAGGGAGGCAAGGATTCCTGCCAGCGTGACTCTGGTGGCCCTGTGGTCTGCAACGGACAGCTCC
AAGGAGTTGTCTCCTGGGGCCATGGCTGTGCCTGGAAGAACAGGCCTGGAGTCTACACCAAGGTCTACAACTATGTGGACTGGATTAAGG

>22060_22060_7_DDX58-PRSS3_DDX58_chr9_32500803_ENST00000379883_PRSS3_chr9_33796641_ENST00000379405_length(amino acids)=320AA_BP=86
MQAEAGMTTEQRRSLQAFQDYIRKTLDPTYILSYMAPWFREEEVQYIQAEKNNKGPMEAATLFLKFLLELQEEGWFRGFLDALDHAVAVP
FDDDDKIVGGYTCEENSLPYQVSLNSGSHFCGGSLISEQWVVSAAHCYKTRIQVRLGEHNIKVLEGNEQFINAAKIIRHPKYNRDTLDND
IMLIKLSSPAVINARVSTISLPTTPPAAGTECLISGWGNTLSFGADYPDELKCLDAPVLTQAECKASYPGKITNSMFCVGFLEGGKDSCQ

--------------------------------------------------------------
>22060_22060_8_DDX58-PRSS3_DDX58_chr9_32500803_ENST00000379883_PRSS3_chr9_33796641_ENST00000429677_length(transcript)=1153nt_BP=399nt
TAGTTATTAAAGTTCCTATGCAGCTCCGCCTCGCGTCCGGCCTCATTTCCTCGGAAAATCCCTGCTTTCCCCGCTCGCCACGCCCTCCTC
CTACCCGGCTTTAAAGCTAGTGAGGCACAGCCTGCGGGGAACGTAGCTAGCTGCAAGCAGAGGCCGGCATGACCACCGAGCAGCGACGCA
GCCTGCAAGCCTTCCAGGATTATATCCGGAAGACCCTGGACCCTACCTACATCCTGAGCTACATGGCCCCCTGGTTTAGGGAGGAAGAGG
TGCAGTATATTCAGGCTGAGAAAAACAACAAGGGCCCAATGGAGGCTGCCACACTTTTTCTCAAGTTCCTGTTGGAGCTCCAGGAGGAAG
GCTGGTTCCGTGGCTTTTTGGATGCCCTAGACCATGCAGTTGCTGTCCCCTTTGACGATGATGACAAGATTGTTGGGGGCTACACCTGTG
AGGAGAATTCTCTCCCCTACCAGGTGTCCCTGAATTCTGGCTCCCACTTCTGCGGTGGCTCCCTCATCAGCGAACAGTGGGTGGTATCAG
CAGCTCACTGCTACAAGACCCGCATCCAGGTGAGACTGGGAGAGCACAACATCAAAGTCCTGGAGGGGAATGAGCAGTTCATCAATGCGG
CCAAGATCATCCGCCACCCTAAATACAACAGGGACACTCTGGACAATGACATCATGCTGATCAAACTCTCCTCACCTGCCGTCATCAATG
CCCGCGTGTCCACCATCTCTCTGCCCACCACCCCTCCAGCTGCTGGCACTGAGTGCCTCATCTCCGGCTGGGGCAACACTCTGAGCTTTG
GTGCTGACTACCCAGACGAGCTGAAGTGCCTGGATGCTCCGGTGCTGACCCAGGCTGAGTGTAAAGCCTCCTACCCTGGAAAGATTACCA
ACAGCATGTTCTGTGTGGGCTTCCTTGAGGGAGGCAAGGATTCCTGCCAGCGTGACTCTGGTGGCCCTGTGGTCTGCAACGGACAGCTCC
AAGGAGTTGTCTCCTGGGGCCATGGCTGTGCCTGGAAGAACAGGCCTGGAGTCTACACCAAGGTCTACAACTATGTGGACTGGATTAAGG

>22060_22060_8_DDX58-PRSS3_DDX58_chr9_32500803_ENST00000379883_PRSS3_chr9_33796641_ENST00000429677_length(amino acids)=320AA_BP=86
MQAEAGMTTEQRRSLQAFQDYIRKTLDPTYILSYMAPWFREEEVQYIQAEKNNKGPMEAATLFLKFLLELQEEGWFRGFLDALDHAVAVP
FDDDDKIVGGYTCEENSLPYQVSLNSGSHFCGGSLISEQWVVSAAHCYKTRIQVRLGEHNIKVLEGNEQFINAAKIIRHPKYNRDTLDND
IMLIKLSSPAVINARVSTISLPTTPPAAGTECLISGWGNTLSFGADYPDELKCLDAPVLTQAECKASYPGKITNSMFCVGFLEGGKDSCQ

--------------------------------------------------------------

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Fusion Gene PPI Analysis for DDX58-PRSS3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneDDX58chr9:32500802chr9:33796640ENST00000379882-117218_9250881.0ZC3HAV1
HgeneDDX58chr9:32500802chr9:33796640ENST00000379883-218218_92580.33333333333333926.0ZC3HAV1
HgeneDDX58chr9:32500803chr9:33796641ENST00000379882-117218_9250881.0ZC3HAV1
HgeneDDX58chr9:32500803chr9:33796641ENST00000379883-218218_92580.33333333333333926.0ZC3HAV1


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for DDX58-PRSS3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for DDX58-PRSS3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneDDX58C0019196Hepatitis C1CTD_human
HgeneDDX58C0021400Influenza1CTD_human
HgeneDDX58C0030246Pustulosis of Palms and Soles1CTD_human
HgeneDDX58C0033860Psoriasis1CTD_human
HgeneDDX58C0235874Disease Exacerbation1CTD_human
HgeneDDX58C0432254Singleton Merten syndrome1ORPHANET
HgeneDDX58C4225380SINGLETON-MERTEN SYNDROME 21UNIPROT
HgeneDDX58C4225427SINGLETON-MERTEN SYNDROME 11GENOMICS_ENGLAND
TgeneC0005684Malignant neoplasm of urinary bladder1CTD_human
TgeneC0005695Bladder Neoplasm1CTD_human