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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:AMACR-NDUFAF2 (FusionGDB2 ID:HG23600TG91942)

Fusion Gene Summary for AMACR-NDUFAF2

check button Fusion gene summary
Fusion gene informationFusion gene name: AMACR-NDUFAF2
Fusion gene ID: hg23600tg91942
HgeneTgene
Gene symbol

AMACR

NDUFAF2

Gene ID

23600

91942

Gene namealpha-methylacyl-CoA racemaseNADH:ubiquinone oxidoreductase complex assembly factor 2
SynonymsAMACRD|CBAS4|P504S|RACE|RMB17.2L|MC1DN10|MMTN|NDUFA12L|mimitin
Cytomap('AMACR')('NDUFAF2')

5p13.2

5q12.1

Type of geneprotein-codingprotein-coding
Descriptionalpha-methylacyl-CoA racemase2-methylacyl-CoA racemaseNADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 2Myc-induced mitochondrial proteinNADH dehydrogenase (ubiquinone) 1 alpha subcomplex, assembly factor 2NADH dehydrogenase (ubiquinone) complex I, assembly factor 2NADH dehydrogenase 1
Modification date2020031320200313
UniProtAcc

Q9UHK6

.
Ensembl transtripts involved in fusion geneENST00000335606, ENST00000382068, 
ENST00000382072, ENST00000382085, 
ENST00000426255, ENST00000441713, 
ENST00000502637, ENST00000512079, 
ENST00000514195, 
Fusion gene scores* DoF score2 X 3 X 3=1813 X 7 X 9=819
# samples 315
** MAII scorelog2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(15/819*10)=-2.44890095114513
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: AMACR [Title/Abstract] AND NDUFAF2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointAMACR(33998745)-NDUFAF2(60368951), # samples:2
AMACR(33998746)-NDUFAF2(60368952), # samples:2
Anticipated loss of major functional domain due to fusion event.AMACR-NDUFAF2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
AMACR-NDUFAF2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
AMACR-NDUFAF2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
AMACR-NDUFAF2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
AMACR-NDUFAF2 seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
AMACR-NDUFAF2 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneAMACR

GO:0008206

bile acid metabolic process

10655068


check buttonFusion gene breakpoints across AMACR (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across NDUFAF2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4PRADTCGA-EJ-8474-01AAMACRchr5

33998746

-NDUFAF2chr5

60368952

+
ChimerDB4PRADTCGA-EJ-8474AMACRchr5

33998745

-NDUFAF2chr5

60368951

+
ChimerDB4PRADTCGA-EJ-8474AMACRchr5

33998746

-NDUFAF2chr5

60368952

+


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Fusion Gene ORF analysis for AMACR-NDUFAF2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000335606ENST00000512623AMACRchr5

33998745

-NDUFAF2chr5

60368951

+
5CDS-3UTRENST00000335606ENST00000512623AMACRchr5

33998746

-NDUFAF2chr5

60368952

+
5CDS-3UTRENST00000382068ENST00000512623AMACRchr5

33998745

-NDUFAF2chr5

60368951

+
5CDS-3UTRENST00000382068ENST00000512623AMACRchr5

33998746

-NDUFAF2chr5

60368952

+
5CDS-3UTRENST00000382072ENST00000512623AMACRchr5

33998745

-NDUFAF2chr5

60368951

+
5CDS-3UTRENST00000382072ENST00000512623AMACRchr5

33998746

-NDUFAF2chr5

60368952

+
5CDS-3UTRENST00000382085ENST00000512623AMACRchr5

33998745

-NDUFAF2chr5

60368951

+
5CDS-3UTRENST00000382085ENST00000512623AMACRchr5

33998746

-NDUFAF2chr5

60368952

+
5CDS-3UTRENST00000426255ENST00000512623AMACRchr5

33998745

-NDUFAF2chr5

60368951

+
5CDS-3UTRENST00000426255ENST00000512623AMACRchr5

33998746

-NDUFAF2chr5

60368952

+
5CDS-3UTRENST00000441713ENST00000512623AMACRchr5

33998745

-NDUFAF2chr5

60368951

+
5CDS-3UTRENST00000441713ENST00000512623AMACRchr5

33998746

-NDUFAF2chr5

60368952

+
5CDS-3UTRENST00000502637ENST00000512623AMACRchr5

33998745

-NDUFAF2chr5

60368951

+
5CDS-3UTRENST00000502637ENST00000512623AMACRchr5

33998746

-NDUFAF2chr5

60368952

+
5CDS-3UTRENST00000512079ENST00000512623AMACRchr5

33998745

-NDUFAF2chr5

60368951

+
5CDS-3UTRENST00000512079ENST00000512623AMACRchr5

33998746

-NDUFAF2chr5

60368952

+
5CDS-intronENST00000335606ENST00000511107AMACRchr5

33998745

-NDUFAF2chr5

60368951

+
5CDS-intronENST00000335606ENST00000511107AMACRchr5

33998746

-NDUFAF2chr5

60368952

+
5CDS-intronENST00000382068ENST00000511107AMACRchr5

33998745

-NDUFAF2chr5

60368951

+
5CDS-intronENST00000382068ENST00000511107AMACRchr5

33998746

-NDUFAF2chr5

60368952

+
5CDS-intronENST00000382072ENST00000511107AMACRchr5

33998745

-NDUFAF2chr5

60368951

+
5CDS-intronENST00000382072ENST00000511107AMACRchr5

33998746

-NDUFAF2chr5

60368952

+
5CDS-intronENST00000382085ENST00000511107AMACRchr5

33998745

-NDUFAF2chr5

60368951

+
5CDS-intronENST00000382085ENST00000511107AMACRchr5

33998746

-NDUFAF2chr5

60368952

+
5CDS-intronENST00000426255ENST00000511107AMACRchr5

33998745

-NDUFAF2chr5

60368951

+
5CDS-intronENST00000426255ENST00000511107AMACRchr5

33998746

-NDUFAF2chr5

60368952

+
5CDS-intronENST00000441713ENST00000511107AMACRchr5

33998745

-NDUFAF2chr5

60368951

+
5CDS-intronENST00000441713ENST00000511107AMACRchr5

33998746

-NDUFAF2chr5

60368952

+
5CDS-intronENST00000502637ENST00000511107AMACRchr5

33998745

-NDUFAF2chr5

60368951

+
5CDS-intronENST00000502637ENST00000511107AMACRchr5

33998746

-NDUFAF2chr5

60368952

+
5CDS-intronENST00000512079ENST00000511107AMACRchr5

33998745

-NDUFAF2chr5

60368951

+
5CDS-intronENST00000512079ENST00000511107AMACRchr5

33998746

-NDUFAF2chr5

60368952

+
5UTR-3CDSENST00000514195ENST00000296597AMACRchr5

33998745

-NDUFAF2chr5

60368951

+
5UTR-3CDSENST00000514195ENST00000296597AMACRchr5

33998746

-NDUFAF2chr5

60368952

+
5UTR-3UTRENST00000514195ENST00000512623AMACRchr5

33998745

-NDUFAF2chr5

60368951

+
5UTR-3UTRENST00000514195ENST00000512623AMACRchr5

33998746

-NDUFAF2chr5

60368952

+
5UTR-intronENST00000514195ENST00000511107AMACRchr5

33998745

-NDUFAF2chr5

60368951

+
5UTR-intronENST00000514195ENST00000511107AMACRchr5

33998746

-NDUFAF2chr5

60368952

+
Frame-shiftENST00000382068ENST00000296597AMACRchr5

33998745

-NDUFAF2chr5

60368951

+
Frame-shiftENST00000382068ENST00000296597AMACRchr5

33998746

-NDUFAF2chr5

60368952

+
Frame-shiftENST00000382072ENST00000296597AMACRchr5

33998745

-NDUFAF2chr5

60368951

+
Frame-shiftENST00000382072ENST00000296597AMACRchr5

33998746

-NDUFAF2chr5

60368952

+
Frame-shiftENST00000441713ENST00000296597AMACRchr5

33998745

-NDUFAF2chr5

60368951

+
Frame-shiftENST00000441713ENST00000296597AMACRchr5

33998746

-NDUFAF2chr5

60368952

+
In-frameENST00000335606ENST00000296597AMACRchr5

33998745

-NDUFAF2chr5

60368951

+
In-frameENST00000335606ENST00000296597AMACRchr5

33998746

-NDUFAF2chr5

60368952

+
In-frameENST00000382085ENST00000296597AMACRchr5

33998745

-NDUFAF2chr5

60368951

+
In-frameENST00000382085ENST00000296597AMACRchr5

33998746

-NDUFAF2chr5

60368952

+
In-frameENST00000426255ENST00000296597AMACRchr5

33998745

-NDUFAF2chr5

60368951

+
In-frameENST00000426255ENST00000296597AMACRchr5

33998746

-NDUFAF2chr5

60368952

+
In-frameENST00000502637ENST00000296597AMACRchr5

33998745

-NDUFAF2chr5

60368951

+
In-frameENST00000502637ENST00000296597AMACRchr5

33998746

-NDUFAF2chr5

60368952

+
In-frameENST00000512079ENST00000296597AMACRchr5

33998745

-NDUFAF2chr5

60368951

+
In-frameENST00000512079ENST00000296597AMACRchr5

33998746

-NDUFAF2chr5

60368952

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000335606AMACRchr533998745-ENST00000296597NDUFAF2chr560368951+1282828111210399
ENST00000382085AMACRchr533998745-ENST00000296597NDUFAF2chr560368951+120274891130373
ENST00000502637AMACRchr533998745-ENST00000296597NDUFAF2chr560368951+123377971161384
ENST00000426255AMACRchr533998745-ENST00000296597NDUFAF2chr560368951+1258804531186377
ENST00000512079AMACRchr533998745-ENST00000296597NDUFAF2chr560368951+120274891130373
ENST00000335606AMACRchr533998746-ENST00000296597NDUFAF2chr560368952+1282828111210399
ENST00000382085AMACRchr533998746-ENST00000296597NDUFAF2chr560368952+120274891130373
ENST00000502637AMACRchr533998746-ENST00000296597NDUFAF2chr560368952+123377971161384
ENST00000426255AMACRchr533998746-ENST00000296597NDUFAF2chr560368952+1258804531186377
ENST00000512079AMACRchr533998746-ENST00000296597NDUFAF2chr560368952+120274891130373

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000335606ENST00000296597AMACRchr533998745-NDUFAF2chr560368951+0.0060770350.9939229
ENST00000382085ENST00000296597AMACRchr533998745-NDUFAF2chr560368951+0.0052140850.99478596
ENST00000502637ENST00000296597AMACRchr533998745-NDUFAF2chr560368951+0.004022820.9959772
ENST00000426255ENST00000296597AMACRchr533998745-NDUFAF2chr560368951+0.0065842830.9934157
ENST00000512079ENST00000296597AMACRchr533998745-NDUFAF2chr560368951+0.0052140850.99478596
ENST00000335606ENST00000296597AMACRchr533998746-NDUFAF2chr560368952+0.0060770350.9939229
ENST00000382085ENST00000296597AMACRchr533998746-NDUFAF2chr560368952+0.0052140850.99478596
ENST00000502637ENST00000296597AMACRchr533998746-NDUFAF2chr560368952+0.004022820.9959772
ENST00000426255ENST00000296597AMACRchr533998746-NDUFAF2chr560368952+0.0065842830.9934157
ENST00000512079ENST00000296597AMACRchr533998746-NDUFAF2chr560368952+0.0052140850.99478596

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Fusion Genomic Features for AMACR-NDUFAF2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
AMACRchr533998745-NDUFAF2chr560368951+2.38E-081
AMACRchr533998745-NDUFAF2chr560368951+2.38E-081
AMACRchr533998745-NDUFAF2chr560368951+2.38E-081
AMACRchr533998745-NDUFAF2chr560368951+2.38E-081

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for AMACR-NDUFAF2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr5:33998745/chr5:60368951)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
AMACR

Q9UHK6

.
FUNCTION: Catalyzes the interconversion of (R)- and (S)-stereoisomers of alpha-methyl-branched-chain fatty acyl-CoA esters (PubMed:7649182, PubMed:10655068, PubMed:11060359). Acts only on coenzyme A thioesters, not on free fatty acids, and accepts as substrates a wide range of alpha-methylacyl-CoAs, including pristanoyl-CoA, trihydroxycoprostanoyl-CoA (an intermediate in bile acid synthesis), and arylpropionic acids like the anti-inflammatory drug ibuprofen (2-(4-isobutylphenyl)propionic acid) but neither 3-methyl-branched nor linear-chain acyl-CoAs (PubMed:7649182, PubMed:10655068, PubMed:11060359). {ECO:0000269|PubMed:10655068, ECO:0000269|PubMed:11060359, ECO:0000269|PubMed:7649182}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneAMACRchr5:33998745chr5:60368951ENST00000335606-45121_126246383.0RegionSubstrate binding
HgeneAMACRchr5:33998745chr5:60368951ENST00000335606-4555_58246383.0RegionSubstrate binding
HgeneAMACRchr5:33998745chr5:60368951ENST00000382072-34121_126192199.0RegionSubstrate binding
HgeneAMACRchr5:33998745chr5:60368951ENST00000382072-3455_58192199.0RegionSubstrate binding
HgeneAMACRchr5:33998745chr5:60368951ENST00000382085-46121_126246395.0RegionSubstrate binding
HgeneAMACRchr5:33998745chr5:60368951ENST00000382085-4655_58246395.0RegionSubstrate binding
HgeneAMACRchr5:33998745chr5:60368951ENST00000441713-34121_126192230.0RegionSubstrate binding
HgeneAMACRchr5:33998745chr5:60368951ENST00000441713-3455_58192230.0RegionSubstrate binding
HgeneAMACRchr5:33998746chr5:60368952ENST00000335606-45121_126246383.0RegionSubstrate binding
HgeneAMACRchr5:33998746chr5:60368952ENST00000335606-4555_58246383.0RegionSubstrate binding
HgeneAMACRchr5:33998746chr5:60368952ENST00000382072-34121_126192199.0RegionSubstrate binding
HgeneAMACRchr5:33998746chr5:60368952ENST00000382072-3455_58192199.0RegionSubstrate binding
HgeneAMACRchr5:33998746chr5:60368952ENST00000382085-46121_126246395.0RegionSubstrate binding
HgeneAMACRchr5:33998746chr5:60368952ENST00000382085-4655_58246395.0RegionSubstrate binding
HgeneAMACRchr5:33998746chr5:60368952ENST00000441713-34121_126192230.0RegionSubstrate binding
HgeneAMACRchr5:33998746chr5:60368952ENST00000441713-3455_58192230.0RegionSubstrate binding

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneAMACRchr5:33998745chr5:60368951ENST00000335606-45380_382246383.0MotifMicrobody targeting signal
HgeneAMACRchr5:33998745chr5:60368951ENST00000382072-34380_382192199.0MotifMicrobody targeting signal
HgeneAMACRchr5:33998745chr5:60368951ENST00000382085-46380_382246395.0MotifMicrobody targeting signal
HgeneAMACRchr5:33998745chr5:60368951ENST00000441713-34380_382192230.0MotifMicrobody targeting signal
HgeneAMACRchr5:33998746chr5:60368952ENST00000335606-45380_382246383.0MotifMicrobody targeting signal
HgeneAMACRchr5:33998746chr5:60368952ENST00000382072-34380_382192199.0MotifMicrobody targeting signal
HgeneAMACRchr5:33998746chr5:60368952ENST00000382085-46380_382246395.0MotifMicrobody targeting signal
HgeneAMACRchr5:33998746chr5:60368952ENST00000441713-34380_382192230.0MotifMicrobody targeting signal


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Fusion Gene Sequence for AMACR-NDUFAF2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>4135_4135_1_AMACR-NDUFAF2_AMACR_chr5_33998745_ENST00000335606_NDUFAF2_chr5_60368951_ENST00000296597_length(transcript)=1282nt_BP=828nt
GGCGCCGGGGATTGGGAGGGCTTCTTGCAGGCTGCTGGGCTGGGGCTAAGGGCTGCTCAGTTTCCTTCAGCGGGGCACTGGGAAGCGCCA
TGGCACTGCAGGGCATCTCGGTCGTGGAGCTGTCCGGCCTGGCCCCGGGCCCGTTCTGTGCTATGGTCCTGGCTGACTTCGGGGCGCGTG
TGGTACGCGTGGACCGGCCCGGCTCCCGCTACGACGTGAGCCGCTTGGGCCGGGGCAAGCGCTCGCTAGTGCTGGACCTGAAGCAGCCGC
GGGGAGCCGCCGTGCTGCGGCGTCTGTGCAAGCGGTCGGATGTGCTGCTGGAGCCCTTCCGCCGCGGTGTCATGGAGAAACTCCAGCTGG
GCCCAGAGATTCTGCAGCGGGAAAATCCAAGGCTTATTTATGCCAGGCTGAGTGGATTTGGCCAGTCAGGAAGCTTCTGCCGGTTAGCTG
GCCACGATATCAACTATTTGGCTTTGTCAGGTGTTCTCTCAAAAATTGGCAGAAGTGGTGAGAATCCGTATGCCCCGCTGAATCTCCTGG
CTGACTTTGCTGGTGGTGGCCTTATGTGTGCACTGGGCATTATAATGGCTCTTTTTGACCGCACACGCACTGGCAAGGGTCAGGTCATTG
ATGCAAATATGGTGGAAGGAACAGCATATTTAAGTTCTTTTCTGTGGAAAACTCAGAAATTGAGTCTGTGGGAAGCACCTCGAGGACAGA
ACATGTTGGATGGTGGAGCACCTTTCTATACGACTTACAGGACAGCAGATGGGGAATTCATGGCTGTTGGAGCAATAGAACCCCAGTTCT
ACGAGCTGCTGATCAAAGGACAAACTATTCGAGAGAAAAGAATTGTAGAAGCAGCAAATAAAAAAGAAGTAGACTATGAAGCAGGGGATA
TTCCAACAGAATGGGAAGCTTGGATTAGAAGAACAAGAAAGACTCCACCTACTATGGAGGAAATACTAAAGAATGAAAAACACAGAGAAG
AAATCAAAATAAAAAGCCAAGATTTTTATGAAAAAGAAAAACTCCTTAGTAAAGAGACCAGTGAGGAACTCCTGCCTCCACCAGTTCAAA
CTCAAATTAAAGGCCATGCCTCTGCTCCATACTTTGGAAAGGAAGAACCCTCAGTGGCTCCCAGCAGCACTGGTAAAACCTTTCAGCCAG
GATCCTGGATGCCACGAGATGGCAAGAGCCACAATCAATGAATGCATTATGGTCAAATCTTTTCATGTATATGGATGTGACTATTTTAAC

>4135_4135_1_AMACR-NDUFAF2_AMACR_chr5_33998745_ENST00000335606_NDUFAF2_chr5_60368951_ENST00000296597_length(amino acids)=399AA_BP=272
MGGLLAGCWAGAKGCSVSFSGALGSAMALQGISVVELSGLAPGPFCAMVLADFGARVVRVDRPGSRYDVSRLGRGKRSLVLDLKQPRGAA
VLRRLCKRSDVLLEPFRRGVMEKLQLGPEILQRENPRLIYARLSGFGQSGSFCRLAGHDINYLALSGVLSKIGRSGENPYAPLNLLADFA
GGGLMCALGIIMALFDRTRTGKGQVIDANMVEGTAYLSSFLWKTQKLSLWEAPRGQNMLDGGAPFYTTYRTADGEFMAVGAIEPQFYELL
IKGQTIREKRIVEAANKKEVDYEAGDIPTEWEAWIRRTRKTPPTMEEILKNEKHREEIKIKSQDFYEKEKLLSKETSEELLPPPVQTQIK

--------------------------------------------------------------
>4135_4135_2_AMACR-NDUFAF2_AMACR_chr5_33998745_ENST00000382085_NDUFAF2_chr5_60368951_ENST00000296597_length(transcript)=1202nt_BP=748nt
GGAAGCGCCATGGCACTGCAGGGCATCTCGGTCGTGGAGCTGTCCGGCCTGGCCCCGGGCCCGTTCTGTGCTATGGTCCTGGCTGACTTC
GGGGCGCGTGTGGTACGCGTGGACCGGCCCGGCTCCCGCTACGACGTGAGCCGCTTGGGCCGGGGCAAGCGCTCGCTAGTGCTGGACCTG
AAGCAGCCGCGGGGAGCCGCCGTGCTGCGGCGTCTGTGCAAGCGGTCGGATGTGCTGCTGGAGCCCTTCCGCCGCGGTGTCATGGAGAAA
CTCCAGCTGGGCCCAGAGATTCTGCAGCGGGAAAATCCAAGGCTTATTTATGCCAGGCTGAGTGGATTTGGCCAGTCAGGAAGCTTCTGC
CGGTTAGCTGGCCACGATATCAACTATTTGGCTTTGTCAGGTGTTCTCTCAAAAATTGGCAGAAGTGGTGAGAATCCGTATGCCCCGCTG
AATCTCCTGGCTGACTTTGCTGGTGGTGGCCTTATGTGTGCACTGGGCATTATAATGGCTCTTTTTGACCGCACACGCACTGGCAAGGGT
CAGGTCATTGATGCAAATATGGTGGAAGGAACAGCATATTTAAGTTCTTTTCTGTGGAAAACTCAGAAATTGAGTCTGTGGGAAGCACCT
CGAGGACAGAACATGTTGGATGGTGGAGCACCTTTCTATACGACTTACAGGACAGCAGATGGGGAATTCATGGCTGTTGGAGCAATAGAA
CCCCAGTTCTACGAGCTGCTGATCAAAGGACAAACTATTCGAGAGAAAAGAATTGTAGAAGCAGCAAATAAAAAAGAAGTAGACTATGAA
GCAGGGGATATTCCAACAGAATGGGAAGCTTGGATTAGAAGAACAAGAAAGACTCCACCTACTATGGAGGAAATACTAAAGAATGAAAAA
CACAGAGAAGAAATCAAAATAAAAAGCCAAGATTTTTATGAAAAAGAAAAACTCCTTAGTAAAGAGACCAGTGAGGAACTCCTGCCTCCA
CCAGTTCAAACTCAAATTAAAGGCCATGCCTCTGCTCCATACTTTGGAAAGGAAGAACCCTCAGTGGCTCCCAGCAGCACTGGTAAAACC
TTTCAGCCAGGATCCTGGATGCCACGAGATGGCAAGAGCCACAATCAATGAATGCATTATGGTCAAATCTTTTCATGTATATGGATGTGA

>4135_4135_2_AMACR-NDUFAF2_AMACR_chr5_33998745_ENST00000382085_NDUFAF2_chr5_60368951_ENST00000296597_length(amino acids)=373AA_BP=246
MALQGISVVELSGLAPGPFCAMVLADFGARVVRVDRPGSRYDVSRLGRGKRSLVLDLKQPRGAAVLRRLCKRSDVLLEPFRRGVMEKLQL
GPEILQRENPRLIYARLSGFGQSGSFCRLAGHDINYLALSGVLSKIGRSGENPYAPLNLLADFAGGGLMCALGIIMALFDRTRTGKGQVI
DANMVEGTAYLSSFLWKTQKLSLWEAPRGQNMLDGGAPFYTTYRTADGEFMAVGAIEPQFYELLIKGQTIREKRIVEAANKKEVDYEAGD
IPTEWEAWIRRTRKTPPTMEEILKNEKHREEIKIKSQDFYEKEKLLSKETSEELLPPPVQTQIKGHASAPYFGKEEPSVAPSSTGKTFQP

--------------------------------------------------------------
>4135_4135_3_AMACR-NDUFAF2_AMACR_chr5_33998745_ENST00000426255_NDUFAF2_chr5_60368951_ENST00000296597_length(transcript)=1258nt_BP=804nt
TTGCAGGCTGCTGGGCTGGGGCTAAGGGCTGCTCAGTTTCCTTCAGCGGGGCACTGGGAAGCGCCATGGCACTGCAGGGCATCTCGGTCG
TGGAGCTGTCCGGCCTGGCCCCGGGCCCGTTCTGTGCTATGGTCCTGGCTGACTTCGGGGCGCGTGTGGTACGCGTGGACCGGCCCGGCT
CCCGCTACGACGTGAGCCGCTTGGGCCGGGGCAAGCGCTCGCTAGTGCTGGACCTGAAGCAGCCGCGGGGAGCCGCCGTGCTGCGGCGTC
TGTGCAAGCGGTCGGATGTGCTGCTGGAGCCCTTCCGCCGCGGTGTCATGGAGAAACTCCAGCTGGGCCCAGAGATTCTGCAGCGGGAAA
ATCCAAGGCTTATTTATGCCAGGCTGAGTGGATTTGGCCAGTCAGGAAGCTTCTGCCGGTTAGCTGGCCACGATATCAACTATTTGGCTT
TGTCAGGTGTTCTCTCAAAAATTGGCAGAAGTGGTGAGAATCCGTATGCCCCGCTGAATCTCCTGGCTGACTTTGCTGGTGGTGGCCTTA
TGTGTGCACTGGGCATTATAATGGCTCTTTTTGACCGCACACGCACTGGCAAGGGTCAGGTCATTGATGCAAATATGGTGGAAGGAACAG
CATATTTAAGTTCTTTTCTGTGGAAAACTCAGAAATTGAGTCTGTGGGAAGCACCTCGAGGACAGAACATGTTGGATGGTGGAGCACCTT
TCTATACGACTTACAGGACAGCAGATGGGGAATTCATGGCTGTTGGAGCAATAGAACCCCAGTTCTACGAGCTGCTGATCAAAGGACAAA
CTATTCGAGAGAAAAGAATTGTAGAAGCAGCAAATAAAAAAGAAGTAGACTATGAAGCAGGGGATATTCCAACAGAATGGGAAGCTTGGA
TTAGAAGAACAAGAAAGACTCCACCTACTATGGAGGAAATACTAAAGAATGAAAAACACAGAGAAGAAATCAAAATAAAAAGCCAAGATT
TTTATGAAAAAGAAAAACTCCTTAGTAAAGAGACCAGTGAGGAACTCCTGCCTCCACCAGTTCAAACTCAAATTAAAGGCCATGCCTCTG
CTCCATACTTTGGAAAGGAAGAACCCTCAGTGGCTCCCAGCAGCACTGGTAAAACCTTTCAGCCAGGATCCTGGATGCCACGAGATGGCA

>4135_4135_3_AMACR-NDUFAF2_AMACR_chr5_33998745_ENST00000426255_NDUFAF2_chr5_60368951_ENST00000296597_length(amino acids)=377AA_BP=250
MGSAMALQGISVVELSGLAPGPFCAMVLADFGARVVRVDRPGSRYDVSRLGRGKRSLVLDLKQPRGAAVLRRLCKRSDVLLEPFRRGVME
KLQLGPEILQRENPRLIYARLSGFGQSGSFCRLAGHDINYLALSGVLSKIGRSGENPYAPLNLLADFAGGGLMCALGIIMALFDRTRTGK
GQVIDANMVEGTAYLSSFLWKTQKLSLWEAPRGQNMLDGGAPFYTTYRTADGEFMAVGAIEPQFYELLIKGQTIREKRIVEAANKKEVDY
EAGDIPTEWEAWIRRTRKTPPTMEEILKNEKHREEIKIKSQDFYEKEKLLSKETSEELLPPPVQTQIKGHASAPYFGKEEPSVAPSSTGK

--------------------------------------------------------------
>4135_4135_4_AMACR-NDUFAF2_AMACR_chr5_33998745_ENST00000502637_NDUFAF2_chr5_60368951_ENST00000296597_length(transcript)=1233nt_BP=779nt
CCGGGGATTGGGAGGGCTTCTTGCAGGCTGCTGGGCTGGGGCTAAGGGCTGCTCAGTTTCCTTCAGCGGGGCACTGGGAAGCGCCATGGC
ACTGCAGGGCATCTCGGTCGTGGAGCTGTCCGGCCTGGCCCCGGGCCCGTTCTGTGCTATGGTCCTGGCTGACTTCGGGGCGCGTGTGGT
ACGCGTGGACCGGCCCGGCTCCCGCTACGACGTGAGCCGCTTGGGCCGGGGCAAGCGCTCGCTAGTGCTGGACCTGAAGCAGCCGCGGGG
AGCCGCCGTGCTGCGGCGTCTGTGCAAGCGGTCGGATGTGCTGCTGGAGCCCTTCCGCCGCGGTGTCATGGAGAAACTCCAGCTGGGCCC
AGAGATTCTGCAGCGGGAAAATCCAAGGCTTATTTATGCCAGGCTGAGTGGATTTGGCCAGTCAGGAAGCTTCTGCCGGTTAGCTGGCCA
CGATATCAACTATTTGGCTTTGTCAGGTGTTCTCTCAAAAATTGGCAGAAGTGGTGAGAATCCGTATGCCCCGCTGAATCTCCTGGCTGA
CTTTGCTGGTGGTGGCCTTATGTGTGCACTGGGCATTATAATGGCTCTTTTTGACCGCACACGCACTGGCAAGGGTCAGGTCATTGATGC
AAATATGAAATTGAGTCTGTGGGAAGCACCTCGAGGACAGAACATGTTGGATGGTGGAGCACCTTTCTATACGACTTACAGGACAGCAGA
TGGGGAATTCATGGCTGTTGGAGCAATAGAACCCCAGTTCTACGAGCTGCTGATCAAAGGACAAACTATTCGAGAGAAAAGAATTGTAGA
AGCAGCAAATAAAAAAGAAGTAGACTATGAAGCAGGGGATATTCCAACAGAATGGGAAGCTTGGATTAGAAGAACAAGAAAGACTCCACC
TACTATGGAGGAAATACTAAAGAATGAAAAACACAGAGAAGAAATCAAAATAAAAAGCCAAGATTTTTATGAAAAAGAAAAACTCCTTAG
TAAAGAGACCAGTGAGGAACTCCTGCCTCCACCAGTTCAAACTCAAATTAAAGGCCATGCCTCTGCTCCATACTTTGGAAAGGAAGAACC
CTCAGTGGCTCCCAGCAGCACTGGTAAAACCTTTCAGCCAGGATCCTGGATGCCACGAGATGGCAAGAGCCACAATCAATGAATGCATTA

>4135_4135_4_AMACR-NDUFAF2_AMACR_chr5_33998745_ENST00000502637_NDUFAF2_chr5_60368951_ENST00000296597_length(amino acids)=384AA_BP=257
MGGLLAGCWAGAKGCSVSFSGALGSAMALQGISVVELSGLAPGPFCAMVLADFGARVVRVDRPGSRYDVSRLGRGKRSLVLDLKQPRGAA
VLRRLCKRSDVLLEPFRRGVMEKLQLGPEILQRENPRLIYARLSGFGQSGSFCRLAGHDINYLALSGVLSKIGRSGENPYAPLNLLADFA
GGGLMCALGIIMALFDRTRTGKGQVIDANMKLSLWEAPRGQNMLDGGAPFYTTYRTADGEFMAVGAIEPQFYELLIKGQTIREKRIVEAA
NKKEVDYEAGDIPTEWEAWIRRTRKTPPTMEEILKNEKHREEIKIKSQDFYEKEKLLSKETSEELLPPPVQTQIKGHASAPYFGKEEPSV

--------------------------------------------------------------
>4135_4135_5_AMACR-NDUFAF2_AMACR_chr5_33998745_ENST00000512079_NDUFAF2_chr5_60368951_ENST00000296597_length(transcript)=1202nt_BP=748nt
GGAAGCGCCATGGCACTGCAGGGCATCTCGGTCGTGGAGCTGTCCGGCCTGGCCCCGGGCCCGTTCTGTGCTATGGTCCTGGCTGACTTC
GGGGCGCGTGTGGTACGCGTGGACCGGCCCGGCTCCCGCTACGACGTGAGCCGCTTGGGCCGGGGCAAGCGCTCGCTAGTGCTGGACCTG
AAGCAGCCGCGGGGAGCCGCCGTGCTGCGGCGTCTGTGCAAGCGGTCGGATGTGCTGCTGGAGCCCTTCCGCCGCGGTGTCATGGAGAAA
CTCCAGCTGGGCCCAGAGATTCTGCAGCGGGAAAATCCAAGGCTTATTTATGCCAGGCTGAGTGGATTTGGCCAGTCAGGAAGCTTCTGC
CGGTTAGCTGGCCACGATATCAACTATTTGGCTTTGTCAGGTGTTCTCTCAAAAATTGGCAGAAGTGGTGAGAATCCGTATGCCCCGCTG
AATCTCCTGGCTGACTTTGCTGGTGGTGGCCTTATGTGTGCACTGGGCATTATAATGGCTCTTTTTGACCGCACACGCACTGGCAAGGGT
CAGGTCATTGATGCAAATATGGTGGAAGGAACAGCATATTTAAGTTCTTTTCTGTGGAAAACTCAGAAATTGAGTCTGTGGGAAGCACCT
CGAGGACAGAACATGTTGGATGGTGGAGCACCTTTCTATACGACTTACAGGACAGCAGATGGGGAATTCATGGCTGTTGGAGCAATAGAA
CCCCAGTTCTACGAGCTGCTGATCAAAGGACAAACTATTCGAGAGAAAAGAATTGTAGAAGCAGCAAATAAAAAAGAAGTAGACTATGAA
GCAGGGGATATTCCAACAGAATGGGAAGCTTGGATTAGAAGAACAAGAAAGACTCCACCTACTATGGAGGAAATACTAAAGAATGAAAAA
CACAGAGAAGAAATCAAAATAAAAAGCCAAGATTTTTATGAAAAAGAAAAACTCCTTAGTAAAGAGACCAGTGAGGAACTCCTGCCTCCA
CCAGTTCAAACTCAAATTAAAGGCCATGCCTCTGCTCCATACTTTGGAAAGGAAGAACCCTCAGTGGCTCCCAGCAGCACTGGTAAAACC
TTTCAGCCAGGATCCTGGATGCCACGAGATGGCAAGAGCCACAATCAATGAATGCATTATGGTCAAATCTTTTCATGTATATGGATGTGA

>4135_4135_5_AMACR-NDUFAF2_AMACR_chr5_33998745_ENST00000512079_NDUFAF2_chr5_60368951_ENST00000296597_length(amino acids)=373AA_BP=246
MALQGISVVELSGLAPGPFCAMVLADFGARVVRVDRPGSRYDVSRLGRGKRSLVLDLKQPRGAAVLRRLCKRSDVLLEPFRRGVMEKLQL
GPEILQRENPRLIYARLSGFGQSGSFCRLAGHDINYLALSGVLSKIGRSGENPYAPLNLLADFAGGGLMCALGIIMALFDRTRTGKGQVI
DANMVEGTAYLSSFLWKTQKLSLWEAPRGQNMLDGGAPFYTTYRTADGEFMAVGAIEPQFYELLIKGQTIREKRIVEAANKKEVDYEAGD
IPTEWEAWIRRTRKTPPTMEEILKNEKHREEIKIKSQDFYEKEKLLSKETSEELLPPPVQTQIKGHASAPYFGKEEPSVAPSSTGKTFQP

--------------------------------------------------------------
>4135_4135_6_AMACR-NDUFAF2_AMACR_chr5_33998746_ENST00000335606_NDUFAF2_chr5_60368952_ENST00000296597_length(transcript)=1282nt_BP=828nt
GGCGCCGGGGATTGGGAGGGCTTCTTGCAGGCTGCTGGGCTGGGGCTAAGGGCTGCTCAGTTTCCTTCAGCGGGGCACTGGGAAGCGCCA
TGGCACTGCAGGGCATCTCGGTCGTGGAGCTGTCCGGCCTGGCCCCGGGCCCGTTCTGTGCTATGGTCCTGGCTGACTTCGGGGCGCGTG
TGGTACGCGTGGACCGGCCCGGCTCCCGCTACGACGTGAGCCGCTTGGGCCGGGGCAAGCGCTCGCTAGTGCTGGACCTGAAGCAGCCGC
GGGGAGCCGCCGTGCTGCGGCGTCTGTGCAAGCGGTCGGATGTGCTGCTGGAGCCCTTCCGCCGCGGTGTCATGGAGAAACTCCAGCTGG
GCCCAGAGATTCTGCAGCGGGAAAATCCAAGGCTTATTTATGCCAGGCTGAGTGGATTTGGCCAGTCAGGAAGCTTCTGCCGGTTAGCTG
GCCACGATATCAACTATTTGGCTTTGTCAGGTGTTCTCTCAAAAATTGGCAGAAGTGGTGAGAATCCGTATGCCCCGCTGAATCTCCTGG
CTGACTTTGCTGGTGGTGGCCTTATGTGTGCACTGGGCATTATAATGGCTCTTTTTGACCGCACACGCACTGGCAAGGGTCAGGTCATTG
ATGCAAATATGGTGGAAGGAACAGCATATTTAAGTTCTTTTCTGTGGAAAACTCAGAAATTGAGTCTGTGGGAAGCACCTCGAGGACAGA
ACATGTTGGATGGTGGAGCACCTTTCTATACGACTTACAGGACAGCAGATGGGGAATTCATGGCTGTTGGAGCAATAGAACCCCAGTTCT
ACGAGCTGCTGATCAAAGGACAAACTATTCGAGAGAAAAGAATTGTAGAAGCAGCAAATAAAAAAGAAGTAGACTATGAAGCAGGGGATA
TTCCAACAGAATGGGAAGCTTGGATTAGAAGAACAAGAAAGACTCCACCTACTATGGAGGAAATACTAAAGAATGAAAAACACAGAGAAG
AAATCAAAATAAAAAGCCAAGATTTTTATGAAAAAGAAAAACTCCTTAGTAAAGAGACCAGTGAGGAACTCCTGCCTCCACCAGTTCAAA
CTCAAATTAAAGGCCATGCCTCTGCTCCATACTTTGGAAAGGAAGAACCCTCAGTGGCTCCCAGCAGCACTGGTAAAACCTTTCAGCCAG
GATCCTGGATGCCACGAGATGGCAAGAGCCACAATCAATGAATGCATTATGGTCAAATCTTTTCATGTATATGGATGTGACTATTTTAAC

>4135_4135_6_AMACR-NDUFAF2_AMACR_chr5_33998746_ENST00000335606_NDUFAF2_chr5_60368952_ENST00000296597_length(amino acids)=399AA_BP=272
MGGLLAGCWAGAKGCSVSFSGALGSAMALQGISVVELSGLAPGPFCAMVLADFGARVVRVDRPGSRYDVSRLGRGKRSLVLDLKQPRGAA
VLRRLCKRSDVLLEPFRRGVMEKLQLGPEILQRENPRLIYARLSGFGQSGSFCRLAGHDINYLALSGVLSKIGRSGENPYAPLNLLADFA
GGGLMCALGIIMALFDRTRTGKGQVIDANMVEGTAYLSSFLWKTQKLSLWEAPRGQNMLDGGAPFYTTYRTADGEFMAVGAIEPQFYELL
IKGQTIREKRIVEAANKKEVDYEAGDIPTEWEAWIRRTRKTPPTMEEILKNEKHREEIKIKSQDFYEKEKLLSKETSEELLPPPVQTQIK

--------------------------------------------------------------
>4135_4135_7_AMACR-NDUFAF2_AMACR_chr5_33998746_ENST00000382085_NDUFAF2_chr5_60368952_ENST00000296597_length(transcript)=1202nt_BP=748nt
GGAAGCGCCATGGCACTGCAGGGCATCTCGGTCGTGGAGCTGTCCGGCCTGGCCCCGGGCCCGTTCTGTGCTATGGTCCTGGCTGACTTC
GGGGCGCGTGTGGTACGCGTGGACCGGCCCGGCTCCCGCTACGACGTGAGCCGCTTGGGCCGGGGCAAGCGCTCGCTAGTGCTGGACCTG
AAGCAGCCGCGGGGAGCCGCCGTGCTGCGGCGTCTGTGCAAGCGGTCGGATGTGCTGCTGGAGCCCTTCCGCCGCGGTGTCATGGAGAAA
CTCCAGCTGGGCCCAGAGATTCTGCAGCGGGAAAATCCAAGGCTTATTTATGCCAGGCTGAGTGGATTTGGCCAGTCAGGAAGCTTCTGC
CGGTTAGCTGGCCACGATATCAACTATTTGGCTTTGTCAGGTGTTCTCTCAAAAATTGGCAGAAGTGGTGAGAATCCGTATGCCCCGCTG
AATCTCCTGGCTGACTTTGCTGGTGGTGGCCTTATGTGTGCACTGGGCATTATAATGGCTCTTTTTGACCGCACACGCACTGGCAAGGGT
CAGGTCATTGATGCAAATATGGTGGAAGGAACAGCATATTTAAGTTCTTTTCTGTGGAAAACTCAGAAATTGAGTCTGTGGGAAGCACCT
CGAGGACAGAACATGTTGGATGGTGGAGCACCTTTCTATACGACTTACAGGACAGCAGATGGGGAATTCATGGCTGTTGGAGCAATAGAA
CCCCAGTTCTACGAGCTGCTGATCAAAGGACAAACTATTCGAGAGAAAAGAATTGTAGAAGCAGCAAATAAAAAAGAAGTAGACTATGAA
GCAGGGGATATTCCAACAGAATGGGAAGCTTGGATTAGAAGAACAAGAAAGACTCCACCTACTATGGAGGAAATACTAAAGAATGAAAAA
CACAGAGAAGAAATCAAAATAAAAAGCCAAGATTTTTATGAAAAAGAAAAACTCCTTAGTAAAGAGACCAGTGAGGAACTCCTGCCTCCA
CCAGTTCAAACTCAAATTAAAGGCCATGCCTCTGCTCCATACTTTGGAAAGGAAGAACCCTCAGTGGCTCCCAGCAGCACTGGTAAAACC
TTTCAGCCAGGATCCTGGATGCCACGAGATGGCAAGAGCCACAATCAATGAATGCATTATGGTCAAATCTTTTCATGTATATGGATGTGA

>4135_4135_7_AMACR-NDUFAF2_AMACR_chr5_33998746_ENST00000382085_NDUFAF2_chr5_60368952_ENST00000296597_length(amino acids)=373AA_BP=246
MALQGISVVELSGLAPGPFCAMVLADFGARVVRVDRPGSRYDVSRLGRGKRSLVLDLKQPRGAAVLRRLCKRSDVLLEPFRRGVMEKLQL
GPEILQRENPRLIYARLSGFGQSGSFCRLAGHDINYLALSGVLSKIGRSGENPYAPLNLLADFAGGGLMCALGIIMALFDRTRTGKGQVI
DANMVEGTAYLSSFLWKTQKLSLWEAPRGQNMLDGGAPFYTTYRTADGEFMAVGAIEPQFYELLIKGQTIREKRIVEAANKKEVDYEAGD
IPTEWEAWIRRTRKTPPTMEEILKNEKHREEIKIKSQDFYEKEKLLSKETSEELLPPPVQTQIKGHASAPYFGKEEPSVAPSSTGKTFQP

--------------------------------------------------------------
>4135_4135_8_AMACR-NDUFAF2_AMACR_chr5_33998746_ENST00000426255_NDUFAF2_chr5_60368952_ENST00000296597_length(transcript)=1258nt_BP=804nt
TTGCAGGCTGCTGGGCTGGGGCTAAGGGCTGCTCAGTTTCCTTCAGCGGGGCACTGGGAAGCGCCATGGCACTGCAGGGCATCTCGGTCG
TGGAGCTGTCCGGCCTGGCCCCGGGCCCGTTCTGTGCTATGGTCCTGGCTGACTTCGGGGCGCGTGTGGTACGCGTGGACCGGCCCGGCT
CCCGCTACGACGTGAGCCGCTTGGGCCGGGGCAAGCGCTCGCTAGTGCTGGACCTGAAGCAGCCGCGGGGAGCCGCCGTGCTGCGGCGTC
TGTGCAAGCGGTCGGATGTGCTGCTGGAGCCCTTCCGCCGCGGTGTCATGGAGAAACTCCAGCTGGGCCCAGAGATTCTGCAGCGGGAAA
ATCCAAGGCTTATTTATGCCAGGCTGAGTGGATTTGGCCAGTCAGGAAGCTTCTGCCGGTTAGCTGGCCACGATATCAACTATTTGGCTT
TGTCAGGTGTTCTCTCAAAAATTGGCAGAAGTGGTGAGAATCCGTATGCCCCGCTGAATCTCCTGGCTGACTTTGCTGGTGGTGGCCTTA
TGTGTGCACTGGGCATTATAATGGCTCTTTTTGACCGCACACGCACTGGCAAGGGTCAGGTCATTGATGCAAATATGGTGGAAGGAACAG
CATATTTAAGTTCTTTTCTGTGGAAAACTCAGAAATTGAGTCTGTGGGAAGCACCTCGAGGACAGAACATGTTGGATGGTGGAGCACCTT
TCTATACGACTTACAGGACAGCAGATGGGGAATTCATGGCTGTTGGAGCAATAGAACCCCAGTTCTACGAGCTGCTGATCAAAGGACAAA
CTATTCGAGAGAAAAGAATTGTAGAAGCAGCAAATAAAAAAGAAGTAGACTATGAAGCAGGGGATATTCCAACAGAATGGGAAGCTTGGA
TTAGAAGAACAAGAAAGACTCCACCTACTATGGAGGAAATACTAAAGAATGAAAAACACAGAGAAGAAATCAAAATAAAAAGCCAAGATT
TTTATGAAAAAGAAAAACTCCTTAGTAAAGAGACCAGTGAGGAACTCCTGCCTCCACCAGTTCAAACTCAAATTAAAGGCCATGCCTCTG
CTCCATACTTTGGAAAGGAAGAACCCTCAGTGGCTCCCAGCAGCACTGGTAAAACCTTTCAGCCAGGATCCTGGATGCCACGAGATGGCA

>4135_4135_8_AMACR-NDUFAF2_AMACR_chr5_33998746_ENST00000426255_NDUFAF2_chr5_60368952_ENST00000296597_length(amino acids)=377AA_BP=250
MGSAMALQGISVVELSGLAPGPFCAMVLADFGARVVRVDRPGSRYDVSRLGRGKRSLVLDLKQPRGAAVLRRLCKRSDVLLEPFRRGVME
KLQLGPEILQRENPRLIYARLSGFGQSGSFCRLAGHDINYLALSGVLSKIGRSGENPYAPLNLLADFAGGGLMCALGIIMALFDRTRTGK
GQVIDANMVEGTAYLSSFLWKTQKLSLWEAPRGQNMLDGGAPFYTTYRTADGEFMAVGAIEPQFYELLIKGQTIREKRIVEAANKKEVDY
EAGDIPTEWEAWIRRTRKTPPTMEEILKNEKHREEIKIKSQDFYEKEKLLSKETSEELLPPPVQTQIKGHASAPYFGKEEPSVAPSSTGK

--------------------------------------------------------------
>4135_4135_9_AMACR-NDUFAF2_AMACR_chr5_33998746_ENST00000502637_NDUFAF2_chr5_60368952_ENST00000296597_length(transcript)=1233nt_BP=779nt
CCGGGGATTGGGAGGGCTTCTTGCAGGCTGCTGGGCTGGGGCTAAGGGCTGCTCAGTTTCCTTCAGCGGGGCACTGGGAAGCGCCATGGC
ACTGCAGGGCATCTCGGTCGTGGAGCTGTCCGGCCTGGCCCCGGGCCCGTTCTGTGCTATGGTCCTGGCTGACTTCGGGGCGCGTGTGGT
ACGCGTGGACCGGCCCGGCTCCCGCTACGACGTGAGCCGCTTGGGCCGGGGCAAGCGCTCGCTAGTGCTGGACCTGAAGCAGCCGCGGGG
AGCCGCCGTGCTGCGGCGTCTGTGCAAGCGGTCGGATGTGCTGCTGGAGCCCTTCCGCCGCGGTGTCATGGAGAAACTCCAGCTGGGCCC
AGAGATTCTGCAGCGGGAAAATCCAAGGCTTATTTATGCCAGGCTGAGTGGATTTGGCCAGTCAGGAAGCTTCTGCCGGTTAGCTGGCCA
CGATATCAACTATTTGGCTTTGTCAGGTGTTCTCTCAAAAATTGGCAGAAGTGGTGAGAATCCGTATGCCCCGCTGAATCTCCTGGCTGA
CTTTGCTGGTGGTGGCCTTATGTGTGCACTGGGCATTATAATGGCTCTTTTTGACCGCACACGCACTGGCAAGGGTCAGGTCATTGATGC
AAATATGAAATTGAGTCTGTGGGAAGCACCTCGAGGACAGAACATGTTGGATGGTGGAGCACCTTTCTATACGACTTACAGGACAGCAGA
TGGGGAATTCATGGCTGTTGGAGCAATAGAACCCCAGTTCTACGAGCTGCTGATCAAAGGACAAACTATTCGAGAGAAAAGAATTGTAGA
AGCAGCAAATAAAAAAGAAGTAGACTATGAAGCAGGGGATATTCCAACAGAATGGGAAGCTTGGATTAGAAGAACAAGAAAGACTCCACC
TACTATGGAGGAAATACTAAAGAATGAAAAACACAGAGAAGAAATCAAAATAAAAAGCCAAGATTTTTATGAAAAAGAAAAACTCCTTAG
TAAAGAGACCAGTGAGGAACTCCTGCCTCCACCAGTTCAAACTCAAATTAAAGGCCATGCCTCTGCTCCATACTTTGGAAAGGAAGAACC
CTCAGTGGCTCCCAGCAGCACTGGTAAAACCTTTCAGCCAGGATCCTGGATGCCACGAGATGGCAAGAGCCACAATCAATGAATGCATTA

>4135_4135_9_AMACR-NDUFAF2_AMACR_chr5_33998746_ENST00000502637_NDUFAF2_chr5_60368952_ENST00000296597_length(amino acids)=384AA_BP=257
MGGLLAGCWAGAKGCSVSFSGALGSAMALQGISVVELSGLAPGPFCAMVLADFGARVVRVDRPGSRYDVSRLGRGKRSLVLDLKQPRGAA
VLRRLCKRSDVLLEPFRRGVMEKLQLGPEILQRENPRLIYARLSGFGQSGSFCRLAGHDINYLALSGVLSKIGRSGENPYAPLNLLADFA
GGGLMCALGIIMALFDRTRTGKGQVIDANMKLSLWEAPRGQNMLDGGAPFYTTYRTADGEFMAVGAIEPQFYELLIKGQTIREKRIVEAA
NKKEVDYEAGDIPTEWEAWIRRTRKTPPTMEEILKNEKHREEIKIKSQDFYEKEKLLSKETSEELLPPPVQTQIKGHASAPYFGKEEPSV

--------------------------------------------------------------
>4135_4135_10_AMACR-NDUFAF2_AMACR_chr5_33998746_ENST00000512079_NDUFAF2_chr5_60368952_ENST00000296597_length(transcript)=1202nt_BP=748nt
GGAAGCGCCATGGCACTGCAGGGCATCTCGGTCGTGGAGCTGTCCGGCCTGGCCCCGGGCCCGTTCTGTGCTATGGTCCTGGCTGACTTC
GGGGCGCGTGTGGTACGCGTGGACCGGCCCGGCTCCCGCTACGACGTGAGCCGCTTGGGCCGGGGCAAGCGCTCGCTAGTGCTGGACCTG
AAGCAGCCGCGGGGAGCCGCCGTGCTGCGGCGTCTGTGCAAGCGGTCGGATGTGCTGCTGGAGCCCTTCCGCCGCGGTGTCATGGAGAAA
CTCCAGCTGGGCCCAGAGATTCTGCAGCGGGAAAATCCAAGGCTTATTTATGCCAGGCTGAGTGGATTTGGCCAGTCAGGAAGCTTCTGC
CGGTTAGCTGGCCACGATATCAACTATTTGGCTTTGTCAGGTGTTCTCTCAAAAATTGGCAGAAGTGGTGAGAATCCGTATGCCCCGCTG
AATCTCCTGGCTGACTTTGCTGGTGGTGGCCTTATGTGTGCACTGGGCATTATAATGGCTCTTTTTGACCGCACACGCACTGGCAAGGGT
CAGGTCATTGATGCAAATATGGTGGAAGGAACAGCATATTTAAGTTCTTTTCTGTGGAAAACTCAGAAATTGAGTCTGTGGGAAGCACCT
CGAGGACAGAACATGTTGGATGGTGGAGCACCTTTCTATACGACTTACAGGACAGCAGATGGGGAATTCATGGCTGTTGGAGCAATAGAA
CCCCAGTTCTACGAGCTGCTGATCAAAGGACAAACTATTCGAGAGAAAAGAATTGTAGAAGCAGCAAATAAAAAAGAAGTAGACTATGAA
GCAGGGGATATTCCAACAGAATGGGAAGCTTGGATTAGAAGAACAAGAAAGACTCCACCTACTATGGAGGAAATACTAAAGAATGAAAAA
CACAGAGAAGAAATCAAAATAAAAAGCCAAGATTTTTATGAAAAAGAAAAACTCCTTAGTAAAGAGACCAGTGAGGAACTCCTGCCTCCA
CCAGTTCAAACTCAAATTAAAGGCCATGCCTCTGCTCCATACTTTGGAAAGGAAGAACCCTCAGTGGCTCCCAGCAGCACTGGTAAAACC
TTTCAGCCAGGATCCTGGATGCCACGAGATGGCAAGAGCCACAATCAATGAATGCATTATGGTCAAATCTTTTCATGTATATGGATGTGA

>4135_4135_10_AMACR-NDUFAF2_AMACR_chr5_33998746_ENST00000512079_NDUFAF2_chr5_60368952_ENST00000296597_length(amino acids)=373AA_BP=246
MALQGISVVELSGLAPGPFCAMVLADFGARVVRVDRPGSRYDVSRLGRGKRSLVLDLKQPRGAAVLRRLCKRSDVLLEPFRRGVMEKLQL
GPEILQRENPRLIYARLSGFGQSGSFCRLAGHDINYLALSGVLSKIGRSGENPYAPLNLLADFAGGGLMCALGIIMALFDRTRTGKGQVI
DANMVEGTAYLSSFLWKTQKLSLWEAPRGQNMLDGGAPFYTTYRTADGEFMAVGAIEPQFYELLIKGQTIREKRIVEAANKKEVDYEAGD
IPTEWEAWIRRTRKTPPTMEEILKNEKHREEIKIKSQDFYEKEKLLSKETSEELLPPPVQTQIKGHASAPYFGKEEPSVAPSSTGKTFQP

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Fusion Gene PPI Analysis for AMACR-NDUFAF2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for AMACR-NDUFAF2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for AMACR-NDUFAF2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneAMACRC0033578Prostatic Neoplasms3CTD_human
HgeneAMACRC0376358Malignant neoplasm of prostate3CTD_human
HgeneAMACRC1858328Bile acid synthesis defect, congenital, 43CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
HgeneAMACRC3280428Alpha-Methylacyl-CoA Racemase Deficiency3CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
HgeneAMACRC0023893Liver Cirrhosis, Experimental2CTD_human
HgeneAMACRC0001430Adenoma1CTD_human
HgeneAMACRC0009402Colorectal Carcinoma1CTD_human
HgeneAMACRC0009404Colorectal Neoplasms1CTD_human
HgeneAMACRC0011195Dejerine-Sottas Disease (disorder)1CTD_human
HgeneAMACRC0019816Hereditary, Type VII, Motor and Sensory Neuropathy1CTD_human
HgeneAMACRC0023895Liver diseases1CTD_human
HgeneAMACRC0027888Hereditary Motor and Sensory Neuropathies1CTD_human
HgeneAMACRC0036341Schizophrenia1PSYGENET
HgeneAMACRC0086565Liver Dysfunction1CTD_human
HgeneAMACRC0205646Adenoma, Basal Cell1CTD_human
HgeneAMACRC0205647Follicular adenoma1CTD_human
HgeneAMACRC0205648Adenoma, Microcystic1CTD_human
HgeneAMACRC0205649Adenoma, Monomorphic1CTD_human
HgeneAMACRC0205650Papillary adenoma1CTD_human
HgeneAMACRC0205651Adenoma, Trabecular1CTD_human
TgeneC1838979MITOCHONDRIAL COMPLEX I DEFICIENCY4GENOMICS_ENGLAND;ORPHANET
TgeneC0023264Leigh Disease2GENOMICS_ENGLAND
TgeneC4748768MITOCHONDRIAL COMPLEX I DEFICIENCY, NUCLEAR TYPE 102GENOMICS_ENGLAND
TgeneC0752107Brain Diseases, Metabolic, Inherited1CTD_human
TgeneC0752109Brain Diseases, Metabolic, Inborn1CTD_human
TgeneC0752110Central Nervous System Inborn Metabolic Diseases1CTD_human