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![]() | Fusion Gene Summary |
![]() | Fusion Gene ORF analysis |
![]() | Fusion Genomic Features |
![]() | Fusion Protein Features |
![]() | Fusion Gene Sequence |
![]() | Fusion Gene PPI analysis |
![]() | Related Drugs |
![]() | Related Diseases |
Fusion gene:DAPK2-FAM96A (FusionGDB2 ID:HG23604TG84191) |
Fusion Gene Summary for DAPK2-FAM96A |
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Fusion gene information | Fusion gene name: DAPK2-FAM96A | Fusion gene ID: hg23604tg84191 | Hgene | Tgene | Gene symbol | DAPK2 | FAM96A | Gene ID | 23604 | 84191 |
Gene name | death associated protein kinase 2 | cytosolic iron-sulfur assembly component 2A | |
Synonyms | DRP-1|DRP1 | CIA2A|FAM96A | |
Cytomap | ('DAPK2')('FAM96A') 15q22.31 | 15q22.31 | |
Type of gene | protein-coding | protein-coding | |
Description | death-associated protein kinase 2DAP kinase 2DAP-kinase-related protein 1 beta isoform | cytosolic iron-sulfur assembly component 2AMIP18 family protein FAM96Afamily with sequence similarity 96 member A | |
Modification date | 20200313 | 20200313 | |
UniProtAcc | Q9UIK4 | . | |
Ensembl transtripts involved in fusion gene | ENST00000261891, ENST00000457488, ENST00000558069, ENST00000558482, | ||
Fusion gene scores | * DoF score | 9 X 9 X 5=405 | 9 X 8 X 7=504 |
# samples | 10 | 12 | |
** MAII score | log2(10/405*10)=-2.01792190799726 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(12/504*10)=-2.0703893278914 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: DAPK2 [Title/Abstract] AND FAM96A [Title/Abstract] AND fusion [Title/Abstract] | ||
Most frequent breakpoint | DAPK2(64332369)-FAM96A(64381050), # samples:2 DAPK2(64332369)-FAM96A(64367736), # samples:2 | ||
Anticipated loss of major functional domain due to fusion event. | DAPK2-FAM96A seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. DAPK2-FAM96A seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. DAPK2-FAM96A seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF. DAPK2-FAM96A seems lost the major protein functional domain in Hgene partner, which is a kinase due to the frame-shifted ORF. DAPK2-FAM96A seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF. DAPK2-FAM96A seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | DAPK2 | GO:0006468 | protein phosphorylation | 10376525 |
Hgene | DAPK2 | GO:0035556 | intracellular signal transduction | 10376525 |
![]() * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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![]() * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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![]() * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChimerDB4 | LIHC | TCGA-FV-A495-01A | DAPK2 | chr15 | 64332369 | - | FAM96A | chr15 | 64373350 | - |
ChimerDB4 | LIHC | TCGA-FV-A495-01A | DAPK2 | chr15 | 64332369 | - | FAM96A | chr15 | 64381050 | - |
ChimerDB4 | PAAD | TCGA-IB-A5ST-01A | DAPK2 | chr15 | 64332369 | - | FAM96A | chr15 | 64367736 | - |
ChimerDB4 | PAAD | TCGA-IB-A5ST | DAPK2 | chr15 | 64332369 | - | FAM96A | chr15 | 64367736 | - |
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Fusion Gene ORF analysis for DAPK2-FAM96A |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-intron | ENST00000261891 | ENST00000380290 | DAPK2 | chr15 | 64332369 | - | FAM96A | chr15 | 64373350 | - |
5CDS-intron | ENST00000261891 | ENST00000380290 | DAPK2 | chr15 | 64332369 | - | FAM96A | chr15 | 64381050 | - |
5CDS-intron | ENST00000261891 | ENST00000380290 | DAPK2 | chr15 | 64332369 | - | FAM96A | chr15 | 64367736 | - |
5CDS-intron | ENST00000261891 | ENST00000557835 | DAPK2 | chr15 | 64332369 | - | FAM96A | chr15 | 64373350 | - |
5CDS-intron | ENST00000261891 | ENST00000557835 | DAPK2 | chr15 | 64332369 | - | FAM96A | chr15 | 64381050 | - |
5CDS-intron | ENST00000261891 | ENST00000557835 | DAPK2 | chr15 | 64332369 | - | FAM96A | chr15 | 64367736 | - |
5CDS-intron | ENST00000261891 | ENST00000558779 | DAPK2 | chr15 | 64332369 | - | FAM96A | chr15 | 64373350 | - |
5CDS-intron | ENST00000261891 | ENST00000558779 | DAPK2 | chr15 | 64332369 | - | FAM96A | chr15 | 64381050 | - |
5CDS-intron | ENST00000261891 | ENST00000558779 | DAPK2 | chr15 | 64332369 | - | FAM96A | chr15 | 64367736 | - |
5CDS-intron | ENST00000261891 | ENST00000559950 | DAPK2 | chr15 | 64332369 | - | FAM96A | chr15 | 64373350 | - |
5CDS-intron | ENST00000261891 | ENST00000559950 | DAPK2 | chr15 | 64332369 | - | FAM96A | chr15 | 64381050 | - |
5CDS-intron | ENST00000261891 | ENST00000559950 | DAPK2 | chr15 | 64332369 | - | FAM96A | chr15 | 64367736 | - |
5CDS-intron | ENST00000457488 | ENST00000380290 | DAPK2 | chr15 | 64332369 | - | FAM96A | chr15 | 64373350 | - |
5CDS-intron | ENST00000457488 | ENST00000380290 | DAPK2 | chr15 | 64332369 | - | FAM96A | chr15 | 64381050 | - |
5CDS-intron | ENST00000457488 | ENST00000380290 | DAPK2 | chr15 | 64332369 | - | FAM96A | chr15 | 64367736 | - |
5CDS-intron | ENST00000457488 | ENST00000557835 | DAPK2 | chr15 | 64332369 | - | FAM96A | chr15 | 64373350 | - |
5CDS-intron | ENST00000457488 | ENST00000557835 | DAPK2 | chr15 | 64332369 | - | FAM96A | chr15 | 64381050 | - |
5CDS-intron | ENST00000457488 | ENST00000557835 | DAPK2 | chr15 | 64332369 | - | FAM96A | chr15 | 64367736 | - |
5CDS-intron | ENST00000457488 | ENST00000558779 | DAPK2 | chr15 | 64332369 | - | FAM96A | chr15 | 64373350 | - |
5CDS-intron | ENST00000457488 | ENST00000558779 | DAPK2 | chr15 | 64332369 | - | FAM96A | chr15 | 64381050 | - |
5CDS-intron | ENST00000457488 | ENST00000558779 | DAPK2 | chr15 | 64332369 | - | FAM96A | chr15 | 64367736 | - |
5CDS-intron | ENST00000457488 | ENST00000559950 | DAPK2 | chr15 | 64332369 | - | FAM96A | chr15 | 64373350 | - |
5CDS-intron | ENST00000457488 | ENST00000559950 | DAPK2 | chr15 | 64332369 | - | FAM96A | chr15 | 64381050 | - |
5CDS-intron | ENST00000457488 | ENST00000559950 | DAPK2 | chr15 | 64332369 | - | FAM96A | chr15 | 64367736 | - |
5CDS-intron | ENST00000558069 | ENST00000380290 | DAPK2 | chr15 | 64332369 | - | FAM96A | chr15 | 64373350 | - |
5CDS-intron | ENST00000558069 | ENST00000380290 | DAPK2 | chr15 | 64332369 | - | FAM96A | chr15 | 64381050 | - |
5CDS-intron | ENST00000558069 | ENST00000380290 | DAPK2 | chr15 | 64332369 | - | FAM96A | chr15 | 64367736 | - |
5CDS-intron | ENST00000558069 | ENST00000557835 | DAPK2 | chr15 | 64332369 | - | FAM96A | chr15 | 64373350 | - |
5CDS-intron | ENST00000558069 | ENST00000557835 | DAPK2 | chr15 | 64332369 | - | FAM96A | chr15 | 64381050 | - |
5CDS-intron | ENST00000558069 | ENST00000557835 | DAPK2 | chr15 | 64332369 | - | FAM96A | chr15 | 64367736 | - |
5CDS-intron | ENST00000558069 | ENST00000558779 | DAPK2 | chr15 | 64332369 | - | FAM96A | chr15 | 64373350 | - |
5CDS-intron | ENST00000558069 | ENST00000558779 | DAPK2 | chr15 | 64332369 | - | FAM96A | chr15 | 64381050 | - |
5CDS-intron | ENST00000558069 | ENST00000558779 | DAPK2 | chr15 | 64332369 | - | FAM96A | chr15 | 64367736 | - |
5CDS-intron | ENST00000558069 | ENST00000559950 | DAPK2 | chr15 | 64332369 | - | FAM96A | chr15 | 64373350 | - |
5CDS-intron | ENST00000558069 | ENST00000559950 | DAPK2 | chr15 | 64332369 | - | FAM96A | chr15 | 64381050 | - |
5CDS-intron | ENST00000558069 | ENST00000559950 | DAPK2 | chr15 | 64332369 | - | FAM96A | chr15 | 64367736 | - |
5UTR-3CDS | ENST00000558482 | ENST00000300030 | DAPK2 | chr15 | 64332369 | - | FAM96A | chr15 | 64373350 | - |
5UTR-3CDS | ENST00000558482 | ENST00000300030 | DAPK2 | chr15 | 64332369 | - | FAM96A | chr15 | 64381050 | - |
5UTR-3CDS | ENST00000558482 | ENST00000300030 | DAPK2 | chr15 | 64332369 | - | FAM96A | chr15 | 64367736 | - |
5UTR-intron | ENST00000558482 | ENST00000380290 | DAPK2 | chr15 | 64332369 | - | FAM96A | chr15 | 64373350 | - |
5UTR-intron | ENST00000558482 | ENST00000380290 | DAPK2 | chr15 | 64332369 | - | FAM96A | chr15 | 64381050 | - |
5UTR-intron | ENST00000558482 | ENST00000380290 | DAPK2 | chr15 | 64332369 | - | FAM96A | chr15 | 64367736 | - |
5UTR-intron | ENST00000558482 | ENST00000557835 | DAPK2 | chr15 | 64332369 | - | FAM96A | chr15 | 64373350 | - |
5UTR-intron | ENST00000558482 | ENST00000557835 | DAPK2 | chr15 | 64332369 | - | FAM96A | chr15 | 64381050 | - |
5UTR-intron | ENST00000558482 | ENST00000557835 | DAPK2 | chr15 | 64332369 | - | FAM96A | chr15 | 64367736 | - |
5UTR-intron | ENST00000558482 | ENST00000558779 | DAPK2 | chr15 | 64332369 | - | FAM96A | chr15 | 64373350 | - |
5UTR-intron | ENST00000558482 | ENST00000558779 | DAPK2 | chr15 | 64332369 | - | FAM96A | chr15 | 64381050 | - |
5UTR-intron | ENST00000558482 | ENST00000558779 | DAPK2 | chr15 | 64332369 | - | FAM96A | chr15 | 64367736 | - |
5UTR-intron | ENST00000558482 | ENST00000559950 | DAPK2 | chr15 | 64332369 | - | FAM96A | chr15 | 64373350 | - |
5UTR-intron | ENST00000558482 | ENST00000559950 | DAPK2 | chr15 | 64332369 | - | FAM96A | chr15 | 64381050 | - |
5UTR-intron | ENST00000558482 | ENST00000559950 | DAPK2 | chr15 | 64332369 | - | FAM96A | chr15 | 64367736 | - |
Frame-shift | ENST00000261891 | ENST00000300030 | DAPK2 | chr15 | 64332369 | - | FAM96A | chr15 | 64373350 | - |
Frame-shift | ENST00000261891 | ENST00000300030 | DAPK2 | chr15 | 64332369 | - | FAM96A | chr15 | 64381050 | - |
Frame-shift | ENST00000457488 | ENST00000300030 | DAPK2 | chr15 | 64332369 | - | FAM96A | chr15 | 64373350 | - |
Frame-shift | ENST00000457488 | ENST00000300030 | DAPK2 | chr15 | 64332369 | - | FAM96A | chr15 | 64381050 | - |
Frame-shift | ENST00000457488 | ENST00000300030 | DAPK2 | chr15 | 64332369 | - | FAM96A | chr15 | 64367736 | - |
Frame-shift | ENST00000558069 | ENST00000300030 | DAPK2 | chr15 | 64332369 | - | FAM96A | chr15 | 64373350 | - |
Frame-shift | ENST00000558069 | ENST00000300030 | DAPK2 | chr15 | 64332369 | - | FAM96A | chr15 | 64381050 | - |
Frame-shift | ENST00000558069 | ENST00000300030 | DAPK2 | chr15 | 64332369 | - | FAM96A | chr15 | 64367736 | - |
In-frame | ENST00000261891 | ENST00000300030 | DAPK2 | chr15 | 64332369 | - | FAM96A | chr15 | 64367736 | - |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
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Fusion Genomic Features for DAPK2-FAM96A |
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Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
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Fusion Protein Features for DAPK2-FAM96A |
![]() Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr15:64332369/chr15:64381050) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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Hgene | Tgene |
DAPK2 | . |
FUNCTION: Calcium/calmodulin-dependent serine/threonine kinase involved in multiple cellular signaling pathways that trigger cell survival, apoptosis, and autophagy. Regulates both type I apoptotic and type II autophagic cell death signals, depending on the cellular setting. The former is caspase-dependent, while the latter is caspase-independent and is characterized by the accumulation of autophagic vesicles. Acts as a mediator of anoikis and a suppressor of beta-catenin-dependent anchorage-independent growth of malignant epithelial cells. May play a role in granulocytic maturation (PubMed:17347302). Regulates granulocytic motility by controlling cell spreading and polarization (PubMed:24163421). {ECO:0000269|PubMed:17347302, ECO:0000269|PubMed:24163421, ECO:0000269|PubMed:26047703}.; FUNCTION: Isoform 2 is not regulated by calmodulin. It can phosphorylate MYL9. It can induce membrane blebbing and autophagic cell death. | FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | DAPK2 | chr15:64332369 | chr15:64367736 | ENST00000261891 | - | 1 | 11 | 23_285 | 30 | 371.0 | Domain | Protein kinase |
Hgene | DAPK2 | chr15:64332369 | chr15:64367736 | ENST00000457488 | - | 2 | 12 | 23_285 | 30 | 371.0 | Domain | Protein kinase |
Hgene | DAPK2 | chr15:64332369 | chr15:64367736 | ENST00000558069 | - | 2 | 10 | 23_285 | 30 | 489.0 | Domain | Protein kinase |
Hgene | DAPK2 | chr15:64332369 | chr15:64367736 | ENST00000261891 | - | 1 | 11 | 29_37 | 30 | 371.0 | Nucleotide binding | ATP |
Hgene | DAPK2 | chr15:64332369 | chr15:64367736 | ENST00000457488 | - | 2 | 12 | 29_37 | 30 | 371.0 | Nucleotide binding | ATP |
Hgene | DAPK2 | chr15:64332369 | chr15:64367736 | ENST00000558069 | - | 2 | 10 | 29_37 | 30 | 489.0 | Nucleotide binding | ATP |
Hgene | DAPK2 | chr15:64332369 | chr15:64367736 | ENST00000261891 | - | 1 | 11 | 277_344 | 30 | 371.0 | Region | Note=Calmodulin-binding |
Hgene | DAPK2 | chr15:64332369 | chr15:64367736 | ENST00000261891 | - | 1 | 11 | 292_301 | 30 | 371.0 | Region | Autoinhibitory domain |
Hgene | DAPK2 | chr15:64332369 | chr15:64367736 | ENST00000457488 | - | 2 | 12 | 277_344 | 30 | 371.0 | Region | Note=Calmodulin-binding |
Hgene | DAPK2 | chr15:64332369 | chr15:64367736 | ENST00000457488 | - | 2 | 12 | 292_301 | 30 | 371.0 | Region | Autoinhibitory domain |
Hgene | DAPK2 | chr15:64332369 | chr15:64367736 | ENST00000558069 | - | 2 | 10 | 277_344 | 30 | 489.0 | Region | Note=Calmodulin-binding |
Hgene | DAPK2 | chr15:64332369 | chr15:64367736 | ENST00000558069 | - | 2 | 10 | 292_301 | 30 | 489.0 | Region | Autoinhibitory domain |
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Fusion Gene Sequence for DAPK2-FAM96A |
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Fusion Gene PPI Analysis for DAPK2-FAM96A |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for DAPK2-FAM96A |
![]() (DrugBank Version 5.1.8 2021-05-08) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Hgene | DAPK2 | Q9UIK4 | DB12010 | Fostamatinib | Inhibitor | Small molecule | Approved|Investigational |
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Related Diseases for DAPK2-FAM96A |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | DAPK2 | C0019209 | Hepatomegaly | 1 | CTD_human |
Hgene | DAPK2 | C0023487 | Acute Promyelocytic Leukemia | 1 | CTD_human |