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![]() | Fusion Gene Summary |
![]() | Fusion Gene ORF analysis |
![]() | Fusion Genomic Features |
![]() | Fusion Protein Features |
![]() | Fusion Gene Sequence |
![]() | Fusion Gene PPI analysis |
![]() | Related Drugs |
![]() | Related Diseases |
Fusion gene:MKRN1-BRAF (FusionGDB2 ID:HG23608TG673) |
Fusion Gene Summary for MKRN1-BRAF |
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Fusion gene information | Fusion gene name: MKRN1-BRAF | Fusion gene ID: hg23608tg673 | Hgene | Tgene | Gene symbol | MKRN1 | BRAF | Gene ID | 23608 | 673 |
Gene name | makorin ring finger protein 1 | B-Raf proto-oncogene, serine/threonine kinase | |
Synonyms | RNF61 | B-RAF1|B-raf|BRAF1|NS7|RAFB1 | |
Cytomap | ('MKRN1')('BRAF') 7q34 | 7q34 | |
Type of gene | protein-coding | protein-coding | |
Description | E3 ubiquitin-protein ligase makorin-1RING finger protein 61RING-type E3 ubiquitin transferase makorin-1 | serine/threonine-protein kinase B-raf94 kDa B-raf proteinB-Raf proto-oncogene serine/threonine-protein kinase (p94)B-Raf serine/threonine-proteinmurine sarcoma viral (v-raf) oncogene homolog B1proto-oncogene B-Rafv-raf murine sarcoma viral oncogene | |
Modification date | 20200313 | 20200329 | |
UniProtAcc | Q9UHC7 | P15056 | |
Ensembl transtripts involved in fusion gene | ENST00000255977, ENST00000443720, ENST00000474576, ENST00000437223, ENST00000480552, ENST00000481705, | ||
Fusion gene scores | * DoF score | 10 X 11 X 9=990 | 48 X 58 X 16=44544 |
# samples | 15 | 69 | |
** MAII score | log2(15/990*10)=-2.72246602447109 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(69/44544*10)=-6.0124909441832 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: MKRN1 [Title/Abstract] AND BRAF [Title/Abstract] AND fusion [Title/Abstract] | ||
Most frequent breakpoint | MKRN1(140158807)-BRAF(140487384), # samples:3 | ||
Anticipated loss of major functional domain due to fusion event. | MKRN1-BRAF seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. MKRN1-BRAF seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. MKRN1-BRAF seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. MKRN1-BRAF seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | MKRN1 | GO:0000209 | protein polyubiquitination | 19536131 |
Tgene | BRAF | GO:0000186 | activation of MAPKK activity | 29433126 |
Tgene | BRAF | GO:0006468 | protein phosphorylation | 17563371 |
Tgene | BRAF | GO:0010828 | positive regulation of glucose transmembrane transport | 23010278 |
Tgene | BRAF | GO:0033138 | positive regulation of peptidyl-serine phosphorylation | 19667065 |
Tgene | BRAF | GO:0043066 | negative regulation of apoptotic process | 19667065 |
Tgene | BRAF | GO:0070374 | positive regulation of ERK1 and ERK2 cascade | 22065586 |
Tgene | BRAF | GO:0071277 | cellular response to calcium ion | 18567582 |
Tgene | BRAF | GO:0090150 | establishment of protein localization to membrane | 23010278 |
![]() * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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![]() * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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![]() * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChimerDB4 | HNSC | TCGA-DQ-7590-01A | MKRN1 | chr7 | 140158807 | - | BRAF | chr7 | 140481493 | - |
ChimerDB4 | THCA | TCGA-J8-A3O1-01A | MKRN1 | chr7 | 140158807 | - | BRAF | chr7 | 140487384 | - |
ChimerDB4 | THCA | TCGA-J8-A3O1 | MKRN1 | chr7 | 140158806 | - | BRAF | chr7 | 140487384 | - |
ChimerKB3 | . | . | MKRN1 | chr7 | 140158806 | - | BRAF | chr7 | 140481493 | - |
ChimerKB3 | . | . | MKRN1 | chr7 | 140158807 | - | BRAF | chr7 | 140487384 | - |
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Fusion Gene ORF analysis for MKRN1-BRAF |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
In-frame | ENST00000255977 | ENST00000288602 | MKRN1 | chr7 | 140158807 | - | BRAF | chr7 | 140481493 | - |
In-frame | ENST00000255977 | ENST00000288602 | MKRN1 | chr7 | 140158807 | - | BRAF | chr7 | 140487384 | - |
In-frame | ENST00000255977 | ENST00000288602 | MKRN1 | chr7 | 140158806 | - | BRAF | chr7 | 140487384 | - |
In-frame | ENST00000255977 | ENST00000288602 | MKRN1 | chr7 | 140158806 | - | BRAF | chr7 | 140481493 | - |
In-frame | ENST00000443720 | ENST00000288602 | MKRN1 | chr7 | 140158807 | - | BRAF | chr7 | 140481493 | - |
In-frame | ENST00000443720 | ENST00000288602 | MKRN1 | chr7 | 140158807 | - | BRAF | chr7 | 140487384 | - |
In-frame | ENST00000443720 | ENST00000288602 | MKRN1 | chr7 | 140158806 | - | BRAF | chr7 | 140487384 | - |
In-frame | ENST00000443720 | ENST00000288602 | MKRN1 | chr7 | 140158806 | - | BRAF | chr7 | 140481493 | - |
In-frame | ENST00000474576 | ENST00000288602 | MKRN1 | chr7 | 140158807 | - | BRAF | chr7 | 140481493 | - |
In-frame | ENST00000474576 | ENST00000288602 | MKRN1 | chr7 | 140158807 | - | BRAF | chr7 | 140487384 | - |
In-frame | ENST00000474576 | ENST00000288602 | MKRN1 | chr7 | 140158806 | - | BRAF | chr7 | 140487384 | - |
In-frame | ENST00000474576 | ENST00000288602 | MKRN1 | chr7 | 140158806 | - | BRAF | chr7 | 140481493 | - |
intron-3CDS | ENST00000437223 | ENST00000288602 | MKRN1 | chr7 | 140158807 | - | BRAF | chr7 | 140481493 | - |
intron-3CDS | ENST00000437223 | ENST00000288602 | MKRN1 | chr7 | 140158807 | - | BRAF | chr7 | 140487384 | - |
intron-3CDS | ENST00000437223 | ENST00000288602 | MKRN1 | chr7 | 140158806 | - | BRAF | chr7 | 140487384 | - |
intron-3CDS | ENST00000437223 | ENST00000288602 | MKRN1 | chr7 | 140158806 | - | BRAF | chr7 | 140481493 | - |
intron-3CDS | ENST00000480552 | ENST00000288602 | MKRN1 | chr7 | 140158807 | - | BRAF | chr7 | 140481493 | - |
intron-3CDS | ENST00000480552 | ENST00000288602 | MKRN1 | chr7 | 140158807 | - | BRAF | chr7 | 140487384 | - |
intron-3CDS | ENST00000480552 | ENST00000288602 | MKRN1 | chr7 | 140158806 | - | BRAF | chr7 | 140487384 | - |
intron-3CDS | ENST00000480552 | ENST00000288602 | MKRN1 | chr7 | 140158806 | - | BRAF | chr7 | 140481493 | - |
intron-3CDS | ENST00000481705 | ENST00000288602 | MKRN1 | chr7 | 140158807 | - | BRAF | chr7 | 140481493 | - |
intron-3CDS | ENST00000481705 | ENST00000288602 | MKRN1 | chr7 | 140158807 | - | BRAF | chr7 | 140487384 | - |
intron-3CDS | ENST00000481705 | ENST00000288602 | MKRN1 | chr7 | 140158806 | - | BRAF | chr7 | 140487384 | - |
intron-3CDS | ENST00000481705 | ENST00000288602 | MKRN1 | chr7 | 140158806 | - | BRAF | chr7 | 140481493 | - |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
ENST00000255977 | MKRN1 | chr7 | 140158806 | - | ENST00000288602 | BRAF | chr7 | 140481493 | - | 2101 | 996 | 225 | 1982 | 585 |
ENST00000474576 | MKRN1 | chr7 | 140158806 | - | ENST00000288602 | BRAF | chr7 | 140481493 | - | 1839 | 734 | 155 | 1720 | 521 |
ENST00000443720 | MKRN1 | chr7 | 140158806 | - | ENST00000288602 | BRAF | chr7 | 140481493 | - | 2031 | 926 | 155 | 1912 | 585 |
ENST00000255977 | MKRN1 | chr7 | 140158807 | - | ENST00000288602 | BRAF | chr7 | 140487384 | - | 2275 | 996 | 225 | 2156 | 643 |
ENST00000474576 | MKRN1 | chr7 | 140158807 | - | ENST00000288602 | BRAF | chr7 | 140487384 | - | 2013 | 734 | 155 | 1894 | 579 |
ENST00000443720 | MKRN1 | chr7 | 140158807 | - | ENST00000288602 | BRAF | chr7 | 140487384 | - | 2205 | 926 | 155 | 2086 | 643 |
ENST00000255977 | MKRN1 | chr7 | 140158807 | - | ENST00000288602 | BRAF | chr7 | 140481493 | - | 2101 | 996 | 225 | 1982 | 585 |
ENST00000474576 | MKRN1 | chr7 | 140158807 | - | ENST00000288602 | BRAF | chr7 | 140481493 | - | 1839 | 734 | 155 | 1720 | 521 |
ENST00000443720 | MKRN1 | chr7 | 140158807 | - | ENST00000288602 | BRAF | chr7 | 140481493 | - | 2031 | 926 | 155 | 1912 | 585 |
ENST00000255977 | MKRN1 | chr7 | 140158807 | - | ENST00000288602 | BRAF | chr7 | 140487384 | - | 2275 | 996 | 225 | 2156 | 643 |
ENST00000474576 | MKRN1 | chr7 | 140158807 | - | ENST00000288602 | BRAF | chr7 | 140487384 | - | 2013 | 734 | 155 | 1894 | 579 |
ENST00000443720 | MKRN1 | chr7 | 140158807 | - | ENST00000288602 | BRAF | chr7 | 140487384 | - | 2205 | 926 | 155 | 2086 | 643 |
ENST00000255977 | MKRN1 | chr7 | 140158806 | - | ENST00000288602 | BRAF | chr7 | 140487384 | - | 2275 | 996 | 225 | 2156 | 643 |
ENST00000474576 | MKRN1 | chr7 | 140158806 | - | ENST00000288602 | BRAF | chr7 | 140487384 | - | 2013 | 734 | 155 | 1894 | 579 |
ENST00000443720 | MKRN1 | chr7 | 140158806 | - | ENST00000288602 | BRAF | chr7 | 140487384 | - | 2205 | 926 | 155 | 2086 | 643 |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
ENST00000255977 | ENST00000288602 | MKRN1 | chr7 | 140158807 | - | BRAF | chr7 | 140481493 | - | 0.007015029 | 0.99298495 |
ENST00000474576 | ENST00000288602 | MKRN1 | chr7 | 140158807 | - | BRAF | chr7 | 140481493 | - | 0.004497724 | 0.9955023 |
ENST00000443720 | ENST00000288602 | MKRN1 | chr7 | 140158807 | - | BRAF | chr7 | 140481493 | - | 0.007488576 | 0.9925114 |
ENST00000255977 | ENST00000288602 | MKRN1 | chr7 | 140158807 | - | BRAF | chr7 | 140487384 | - | 0.007020649 | 0.99297935 |
ENST00000474576 | ENST00000288602 | MKRN1 | chr7 | 140158807 | - | BRAF | chr7 | 140487384 | - | 0.006438542 | 0.9935615 |
ENST00000443720 | ENST00000288602 | MKRN1 | chr7 | 140158807 | - | BRAF | chr7 | 140487384 | - | 0.007694333 | 0.9923057 |
ENST00000255977 | ENST00000288602 | MKRN1 | chr7 | 140158806 | - | BRAF | chr7 | 140487384 | - | 0.007020649 | 0.99297935 |
ENST00000474576 | ENST00000288602 | MKRN1 | chr7 | 140158806 | - | BRAF | chr7 | 140487384 | - | 0.006438542 | 0.9935615 |
ENST00000443720 | ENST00000288602 | MKRN1 | chr7 | 140158806 | - | BRAF | chr7 | 140487384 | - | 0.007694333 | 0.9923057 |
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Fusion Genomic Features for MKRN1-BRAF |
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Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
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Fusion Protein Features for MKRN1-BRAF |
![]() Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr7:140158807/chr7:140487384) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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Hgene | Tgene |
MKRN1 | BRAF |
FUNCTION: E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. These substrates include FILIP1, p53/TP53, CDKN1A and TERT. Keeps cells alive by suppressing p53/TP53 under normal conditions, but stimulates apoptosis by repressing CDKN1A under stress conditions. Acts as a negative regulator of telomerase. Has negative and positive effects on RNA polymerase II-dependent transcription. {ECO:0000269|PubMed:16785614, ECO:0000269|PubMed:19536131}. | FUNCTION: Protein kinase involved in the transduction of mitogenic signals from the cell membrane to the nucleus (Probable). Phosphorylates MAP2K1, and thereby activates the MAP kinase signal transduction pathway (PubMed:21441910, PubMed:29433126). May play a role in the postsynaptic responses of hippocampal neurons (PubMed:1508179). {ECO:0000269|PubMed:1508179, ECO:0000269|PubMed:21441910, ECO:0000269|PubMed:29433126, ECO:0000305}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | MKRN1 | chr7:140158806 | chr7:140487384 | ENST00000255977 | - | 4 | 8 | 208_235 | 257 | 483.0 | Zinc finger | C3H1-type 3 |
Hgene | MKRN1 | chr7:140158806 | chr7:140487384 | ENST00000255977 | - | 4 | 8 | 55_82 | 257 | 483.0 | Zinc finger | C3H1-type 1 |
Hgene | MKRN1 | chr7:140158806 | chr7:140487384 | ENST00000255977 | - | 4 | 8 | 84_111 | 257 | 483.0 | Zinc finger | C3H1-type 2 |
Hgene | MKRN1 | chr7:140158806 | chr7:140487384 | ENST00000443720 | - | 4 | 5 | 208_235 | 257 | 330.0 | Zinc finger | C3H1-type 3 |
Hgene | MKRN1 | chr7:140158806 | chr7:140487384 | ENST00000443720 | - | 4 | 5 | 55_82 | 257 | 330.0 | Zinc finger | C3H1-type 1 |
Hgene | MKRN1 | chr7:140158806 | chr7:140487384 | ENST00000443720 | - | 4 | 5 | 84_111 | 257 | 330.0 | Zinc finger | C3H1-type 2 |
Hgene | MKRN1 | chr7:140158806 | chr7:140487384 | ENST00000474576 | - | 4 | 8 | 55_82 | 193 | 419.0 | Zinc finger | C3H1-type 1 |
Hgene | MKRN1 | chr7:140158806 | chr7:140487384 | ENST00000474576 | - | 4 | 8 | 84_111 | 193 | 419.0 | Zinc finger | C3H1-type 2 |
Hgene | MKRN1 | chr7:140158807 | chr7:140481493 | ENST00000255977 | - | 4 | 8 | 208_235 | 257 | 483.0 | Zinc finger | C3H1-type 3 |
Hgene | MKRN1 | chr7:140158807 | chr7:140481493 | ENST00000255977 | - | 4 | 8 | 55_82 | 257 | 483.0 | Zinc finger | C3H1-type 1 |
Hgene | MKRN1 | chr7:140158807 | chr7:140481493 | ENST00000255977 | - | 4 | 8 | 84_111 | 257 | 483.0 | Zinc finger | C3H1-type 2 |
Hgene | MKRN1 | chr7:140158807 | chr7:140481493 | ENST00000443720 | - | 4 | 5 | 208_235 | 257 | 330.0 | Zinc finger | C3H1-type 3 |
Hgene | MKRN1 | chr7:140158807 | chr7:140481493 | ENST00000443720 | - | 4 | 5 | 55_82 | 257 | 330.0 | Zinc finger | C3H1-type 1 |
Hgene | MKRN1 | chr7:140158807 | chr7:140481493 | ENST00000443720 | - | 4 | 5 | 84_111 | 257 | 330.0 | Zinc finger | C3H1-type 2 |
Hgene | MKRN1 | chr7:140158807 | chr7:140481493 | ENST00000474576 | - | 4 | 8 | 55_82 | 193 | 419.0 | Zinc finger | C3H1-type 1 |
Hgene | MKRN1 | chr7:140158807 | chr7:140481493 | ENST00000474576 | - | 4 | 8 | 84_111 | 193 | 419.0 | Zinc finger | C3H1-type 2 |
Hgene | MKRN1 | chr7:140158807 | chr7:140487384 | ENST00000255977 | - | 4 | 8 | 208_235 | 257 | 483.0 | Zinc finger | C3H1-type 3 |
Hgene | MKRN1 | chr7:140158807 | chr7:140487384 | ENST00000255977 | - | 4 | 8 | 55_82 | 257 | 483.0 | Zinc finger | C3H1-type 1 |
Hgene | MKRN1 | chr7:140158807 | chr7:140487384 | ENST00000255977 | - | 4 | 8 | 84_111 | 257 | 483.0 | Zinc finger | C3H1-type 2 |
Hgene | MKRN1 | chr7:140158807 | chr7:140487384 | ENST00000443720 | - | 4 | 5 | 208_235 | 257 | 330.0 | Zinc finger | C3H1-type 3 |
Hgene | MKRN1 | chr7:140158807 | chr7:140487384 | ENST00000443720 | - | 4 | 5 | 55_82 | 257 | 330.0 | Zinc finger | C3H1-type 1 |
Hgene | MKRN1 | chr7:140158807 | chr7:140487384 | ENST00000443720 | - | 4 | 5 | 84_111 | 257 | 330.0 | Zinc finger | C3H1-type 2 |
Hgene | MKRN1 | chr7:140158807 | chr7:140487384 | ENST00000474576 | - | 4 | 8 | 55_82 | 193 | 419.0 | Zinc finger | C3H1-type 1 |
Hgene | MKRN1 | chr7:140158807 | chr7:140487384 | ENST00000474576 | - | 4 | 8 | 84_111 | 193 | 419.0 | Zinc finger | C3H1-type 2 |
Tgene | BRAF | chr7:140158806 | chr7:140487384 | ENST00000288602 | 7 | 18 | 428_432 | 380 | 767.0 | Compositional bias | Note=Poly-Ser | |
Tgene | BRAF | chr7:140158807 | chr7:140487384 | ENST00000288602 | 7 | 18 | 428_432 | 380 | 767.0 | Compositional bias | Note=Poly-Ser | |
Tgene | BRAF | chr7:140158806 | chr7:140487384 | ENST00000288602 | 7 | 18 | 457_717 | 380 | 767.0 | Domain | Protein kinase | |
Tgene | BRAF | chr7:140158807 | chr7:140481493 | ENST00000288602 | 9 | 18 | 457_717 | 438 | 767.0 | Domain | Protein kinase | |
Tgene | BRAF | chr7:140158807 | chr7:140487384 | ENST00000288602 | 7 | 18 | 457_717 | 380 | 767.0 | Domain | Protein kinase | |
Tgene | BRAF | chr7:140158806 | chr7:140487384 | ENST00000288602 | 7 | 18 | 463_471 | 380 | 767.0 | Nucleotide binding | ATP | |
Tgene | BRAF | chr7:140158807 | chr7:140481493 | ENST00000288602 | 9 | 18 | 463_471 | 438 | 767.0 | Nucleotide binding | ATP | |
Tgene | BRAF | chr7:140158807 | chr7:140487384 | ENST00000288602 | 7 | 18 | 463_471 | 380 | 767.0 | Nucleotide binding | ATP |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | MKRN1 | chr7:140158806 | chr7:140487384 | ENST00000255977 | - | 4 | 8 | 236_263 | 257 | 483.0 | Region | Note=Makorin-type Cys-His |
Hgene | MKRN1 | chr7:140158806 | chr7:140487384 | ENST00000443720 | - | 4 | 5 | 236_263 | 257 | 330.0 | Region | Note=Makorin-type Cys-His |
Hgene | MKRN1 | chr7:140158806 | chr7:140487384 | ENST00000474576 | - | 4 | 8 | 236_263 | 193 | 419.0 | Region | Note=Makorin-type Cys-His |
Hgene | MKRN1 | chr7:140158807 | chr7:140481493 | ENST00000255977 | - | 4 | 8 | 236_263 | 257 | 483.0 | Region | Note=Makorin-type Cys-His |
Hgene | MKRN1 | chr7:140158807 | chr7:140481493 | ENST00000443720 | - | 4 | 5 | 236_263 | 257 | 330.0 | Region | Note=Makorin-type Cys-His |
Hgene | MKRN1 | chr7:140158807 | chr7:140481493 | ENST00000474576 | - | 4 | 8 | 236_263 | 193 | 419.0 | Region | Note=Makorin-type Cys-His |
Hgene | MKRN1 | chr7:140158807 | chr7:140487384 | ENST00000255977 | - | 4 | 8 | 236_263 | 257 | 483.0 | Region | Note=Makorin-type Cys-His |
Hgene | MKRN1 | chr7:140158807 | chr7:140487384 | ENST00000443720 | - | 4 | 5 | 236_263 | 257 | 330.0 | Region | Note=Makorin-type Cys-His |
Hgene | MKRN1 | chr7:140158807 | chr7:140487384 | ENST00000474576 | - | 4 | 8 | 236_263 | 193 | 419.0 | Region | Note=Makorin-type Cys-His |
Hgene | MKRN1 | chr7:140158806 | chr7:140487384 | ENST00000255977 | - | 4 | 8 | 281_335 | 257 | 483.0 | Zinc finger | RING-type |
Hgene | MKRN1 | chr7:140158806 | chr7:140487384 | ENST00000255977 | - | 4 | 8 | 364_393 | 257 | 483.0 | Zinc finger | C3H1-type 4 |
Hgene | MKRN1 | chr7:140158806 | chr7:140487384 | ENST00000443720 | - | 4 | 5 | 281_335 | 257 | 330.0 | Zinc finger | RING-type |
Hgene | MKRN1 | chr7:140158806 | chr7:140487384 | ENST00000443720 | - | 4 | 5 | 364_393 | 257 | 330.0 | Zinc finger | C3H1-type 4 |
Hgene | MKRN1 | chr7:140158806 | chr7:140487384 | ENST00000474576 | - | 4 | 8 | 208_235 | 193 | 419.0 | Zinc finger | C3H1-type 3 |
Hgene | MKRN1 | chr7:140158806 | chr7:140487384 | ENST00000474576 | - | 4 | 8 | 281_335 | 193 | 419.0 | Zinc finger | RING-type |
Hgene | MKRN1 | chr7:140158806 | chr7:140487384 | ENST00000474576 | - | 4 | 8 | 364_393 | 193 | 419.0 | Zinc finger | C3H1-type 4 |
Hgene | MKRN1 | chr7:140158807 | chr7:140481493 | ENST00000255977 | - | 4 | 8 | 281_335 | 257 | 483.0 | Zinc finger | RING-type |
Hgene | MKRN1 | chr7:140158807 | chr7:140481493 | ENST00000255977 | - | 4 | 8 | 364_393 | 257 | 483.0 | Zinc finger | C3H1-type 4 |
Hgene | MKRN1 | chr7:140158807 | chr7:140481493 | ENST00000443720 | - | 4 | 5 | 281_335 | 257 | 330.0 | Zinc finger | RING-type |
Hgene | MKRN1 | chr7:140158807 | chr7:140481493 | ENST00000443720 | - | 4 | 5 | 364_393 | 257 | 330.0 | Zinc finger | C3H1-type 4 |
Hgene | MKRN1 | chr7:140158807 | chr7:140481493 | ENST00000474576 | - | 4 | 8 | 208_235 | 193 | 419.0 | Zinc finger | C3H1-type 3 |
Hgene | MKRN1 | chr7:140158807 | chr7:140481493 | ENST00000474576 | - | 4 | 8 | 281_335 | 193 | 419.0 | Zinc finger | RING-type |
Hgene | MKRN1 | chr7:140158807 | chr7:140481493 | ENST00000474576 | - | 4 | 8 | 364_393 | 193 | 419.0 | Zinc finger | C3H1-type 4 |
Hgene | MKRN1 | chr7:140158807 | chr7:140487384 | ENST00000255977 | - | 4 | 8 | 281_335 | 257 | 483.0 | Zinc finger | RING-type |
Hgene | MKRN1 | chr7:140158807 | chr7:140487384 | ENST00000255977 | - | 4 | 8 | 364_393 | 257 | 483.0 | Zinc finger | C3H1-type 4 |
Hgene | MKRN1 | chr7:140158807 | chr7:140487384 | ENST00000443720 | - | 4 | 5 | 281_335 | 257 | 330.0 | Zinc finger | RING-type |
Hgene | MKRN1 | chr7:140158807 | chr7:140487384 | ENST00000443720 | - | 4 | 5 | 364_393 | 257 | 330.0 | Zinc finger | C3H1-type 4 |
Hgene | MKRN1 | chr7:140158807 | chr7:140487384 | ENST00000474576 | - | 4 | 8 | 208_235 | 193 | 419.0 | Zinc finger | C3H1-type 3 |
Hgene | MKRN1 | chr7:140158807 | chr7:140487384 | ENST00000474576 | - | 4 | 8 | 281_335 | 193 | 419.0 | Zinc finger | RING-type |
Hgene | MKRN1 | chr7:140158807 | chr7:140487384 | ENST00000474576 | - | 4 | 8 | 364_393 | 193 | 419.0 | Zinc finger | C3H1-type 4 |
Tgene | BRAF | chr7:140158806 | chr7:140487384 | ENST00000288602 | 7 | 18 | 122_129 | 380 | 767.0 | Compositional bias | Note=Poly-Ser | |
Tgene | BRAF | chr7:140158806 | chr7:140487384 | ENST00000288602 | 7 | 18 | 6_11 | 380 | 767.0 | Compositional bias | Note=Poly-Gly | |
Tgene | BRAF | chr7:140158807 | chr7:140481493 | ENST00000288602 | 9 | 18 | 122_129 | 438 | 767.0 | Compositional bias | Note=Poly-Ser | |
Tgene | BRAF | chr7:140158807 | chr7:140481493 | ENST00000288602 | 9 | 18 | 428_432 | 438 | 767.0 | Compositional bias | Note=Poly-Ser | |
Tgene | BRAF | chr7:140158807 | chr7:140481493 | ENST00000288602 | 9 | 18 | 6_11 | 438 | 767.0 | Compositional bias | Note=Poly-Gly | |
Tgene | BRAF | chr7:140158807 | chr7:140487384 | ENST00000288602 | 7 | 18 | 122_129 | 380 | 767.0 | Compositional bias | Note=Poly-Ser | |
Tgene | BRAF | chr7:140158807 | chr7:140487384 | ENST00000288602 | 7 | 18 | 6_11 | 380 | 767.0 | Compositional bias | Note=Poly-Gly | |
Tgene | BRAF | chr7:140158806 | chr7:140487384 | ENST00000288602 | 7 | 18 | 155_227 | 380 | 767.0 | Domain | RBD | |
Tgene | BRAF | chr7:140158807 | chr7:140481493 | ENST00000288602 | 9 | 18 | 155_227 | 438 | 767.0 | Domain | RBD | |
Tgene | BRAF | chr7:140158807 | chr7:140487384 | ENST00000288602 | 7 | 18 | 155_227 | 380 | 767.0 | Domain | RBD | |
Tgene | BRAF | chr7:140158806 | chr7:140487384 | ENST00000288602 | 7 | 18 | 234_280 | 380 | 767.0 | Zinc finger | Phorbol-ester/DAG-type | |
Tgene | BRAF | chr7:140158807 | chr7:140481493 | ENST00000288602 | 9 | 18 | 234_280 | 438 | 767.0 | Zinc finger | Phorbol-ester/DAG-type | |
Tgene | BRAF | chr7:140158807 | chr7:140487384 | ENST00000288602 | 7 | 18 | 234_280 | 380 | 767.0 | Zinc finger | Phorbol-ester/DAG-type |
Top |
Fusion Gene Sequence for MKRN1-BRAF |
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>54112_54112_1_MKRN1-BRAF_MKRN1_chr7_140158806_ENST00000255977_BRAF_chr7_140481493_ENST00000288602_length(transcript)=2101nt_BP=996nt ACCAATGAGCGGCGCCGTGGGCGGGCCGCGGGCGCGCATGCTCTGGGCCCGCAGTTGAAGTGGCGAGAGCGCTCAGATACGCGACGCGTA GCAGGCGGGGACCGAACGGGTGCCTCAGTGTCCTTCCCCTCCCCTCGCCTGGCCTCGCCGTCCTCTCCCCGCAGCCGGACCGGAACTATG TGATCCCGGAAGTTCCGGGGCCTTTGCTGTGTGGGATAAACAGTAATGGCGGAGGCTGCAACTCCCGGAACAACAGCCACAACATCAGGA GCAGGAGCGGCAGCGGCGACGGCGGCAGCAGCCTCCCCCACCCCGATCCCCACAGTCACCGCCCCGTCCCTGGGGGCGGGCGGAGGGGGC GGCGGCAGCGACGGCAGCGGCGGCGGCTGGACTAAACAGGTCACCTGCAGGTATTTTATGCATGGGGTTTGTAAGGAAGGAGACAACTGT CGCTACTCGCATGACCTCTCTGACAGTCCGTATAGTGTAGTGTGCAAGTATTTTCAGCGAGGGTACTGTATTTATGGAGACCGCTGCAGA TATGAACATAGCAAACCATTGAAACAGGAAGAAGCAACTGCTACAGAGCTAACTACAAAGTCATCCCTTGCTGCTTCCTCAAGTCTCTCA TCGATAGTTGGACCACTTGTTGAAATGAATACAGGCGAAGCTGAGTCAAGAAATTCAAACTTTGCAACTGTAGGAGCAGGTTCAGAGGAC TGGGTGAATGCTATTGAGTTTGTTCCTGGGCAACCCTACTGTGGCCGTACTGCGCCTTCCTGCACTGAAGCACCCCTGCAGGGCTCAGTG ACCAAGGAAGAATCAGAGAAAGAGCAAACCGCCGTGGAGACAAAGAAGCAGCTGTGCCCCTATGCTGCAGTGGGAGAGTGCCGATACGGG GAGAACTGTGTGTATCTCCACGGAGATTCTTGTGACATGTGTGGGCTGCAGGTCCTGCATCCAATGGATGCTGCCCAGAGATCGCAGCAT ATCAAAAAAACACTTGGTAGACGGGACTCGAGTGATGATTGGGAGATTCCTGATGGGCAGATTACAGTGGGACAAAGAATTGGATCTGGA TCATTTGGAACAGTCTACAAGGGAAAGTGGCATGGTGATGTGGCAGTGAAAATGTTGAATGTGACAGCACCTACACCTCAGCAGTTACAA GCCTTCAAAAATGAAGTAGGAGTACTCAGGAAAACACGACATGTGAATATCCTACTCTTCATGGGCTATTCCACAAAGCCACAACTGGCT ATTGTTACCCAGTGGTGTGAGGGCTCCAGCTTGTATCACCATCTCCATATCATTGAGACCAAATTTGAGATGATCAAACTTATAGATATT GCACGACAGACTGCACAGGGCATGGATTACTTACACGCCAAGTCAATCATCCACAGAGACCTCAAGAGTAATAATATATTTCTTCATGAA GACCTCACAGTAAAAATAGGTGATTTTGGTCTAGCTACAGTGAAATCTCGATGGAGTGGGTCCCATCAGTTTGAACAGTTGTCTGGATCC ATTTTGTGGATGGCACCAGAAGTCATCAGAATGCAAGATAAAAATCCATACAGCTTTCAGTCAGATGTATATGCATTTGGAATTGTTCTG TATGAATTGATGACTGGACAGTTACCTTATTCAAACATCAACAACAGGGACCAGATAATTTTTATGGTGGGACGAGGATACCTGTCTCCA GATCTCAGTAAGGTACGGAGTAACTGTCCAAAAGCCATGAAGAGATTAATGGCAGAGTGCCTCAAAAAGAAAAGAGATGAGAGACCACTC TTTCCCCAAATTCTCGCCTCTATTGAGCTGCTGGCCCGCTCATTGCCAAAAATTCACCGCAGTGCATCAGAACCCTCCTTGAATCGGGCT GGTTTCCAAACAGAGGATTTTAGTCTATATGCTTGTGCTTCTCCAAAAACACCCATCCAGGCAGGGGGATATGGTGCGTTTCCTGTCCAC TGAAACAAATGAGTGAGAGAGTTCAGGAGAGTAGCAACAAAAGGAAAATAAATGAACATATGTTTGCTTATATGTTAAATTGAATAAAAT >54112_54112_1_MKRN1-BRAF_MKRN1_chr7_140158806_ENST00000255977_BRAF_chr7_140481493_ENST00000288602_length(amino acids)=585AA_BP=255 MAEAATPGTTATTSGAGAAAATAAAASPTPIPTVTAPSLGAGGGGGGSDGSGGGWTKQVTCRYFMHGVCKEGDNCRYSHDLSDSPYSVVC KYFQRGYCIYGDRCRYEHSKPLKQEEATATELTTKSSLAASSSLSSIVGPLVEMNTGEAESRNSNFATVGAGSEDWVNAIEFVPGQPYCG RTAPSCTEAPLQGSVTKEESEKEQTAVETKKQLCPYAAVGECRYGENCVYLHGDSCDMCGLQVLHPMDAAQRSQHIKKTLGRRDSSDDWE IPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHL HIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKN PYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSL -------------------------------------------------------------- >54112_54112_2_MKRN1-BRAF_MKRN1_chr7_140158806_ENST00000255977_BRAF_chr7_140487384_ENST00000288602_length(transcript)=2275nt_BP=996nt ACCAATGAGCGGCGCCGTGGGCGGGCCGCGGGCGCGCATGCTCTGGGCCCGCAGTTGAAGTGGCGAGAGCGCTCAGATACGCGACGCGTA GCAGGCGGGGACCGAACGGGTGCCTCAGTGTCCTTCCCCTCCCCTCGCCTGGCCTCGCCGTCCTCTCCCCGCAGCCGGACCGGAACTATG TGATCCCGGAAGTTCCGGGGCCTTTGCTGTGTGGGATAAACAGTAATGGCGGAGGCTGCAACTCCCGGAACAACAGCCACAACATCAGGA GCAGGAGCGGCAGCGGCGACGGCGGCAGCAGCCTCCCCCACCCCGATCCCCACAGTCACCGCCCCGTCCCTGGGGGCGGGCGGAGGGGGC GGCGGCAGCGACGGCAGCGGCGGCGGCTGGACTAAACAGGTCACCTGCAGGTATTTTATGCATGGGGTTTGTAAGGAAGGAGACAACTGT CGCTACTCGCATGACCTCTCTGACAGTCCGTATAGTGTAGTGTGCAAGTATTTTCAGCGAGGGTACTGTATTTATGGAGACCGCTGCAGA TATGAACATAGCAAACCATTGAAACAGGAAGAAGCAACTGCTACAGAGCTAACTACAAAGTCATCCCTTGCTGCTTCCTCAAGTCTCTCA TCGATAGTTGGACCACTTGTTGAAATGAATACAGGCGAAGCTGAGTCAAGAAATTCAAACTTTGCAACTGTAGGAGCAGGTTCAGAGGAC TGGGTGAATGCTATTGAGTTTGTTCCTGGGCAACCCTACTGTGGCCGTACTGCGCCTTCCTGCACTGAAGCACCCCTGCAGGGCTCAGTG ACCAAGGAAGAATCAGAGAAAGAGCAAACCGCCGTGGAGACAAAGAAGCAGCTGTGCCCCTATGCTGCAGTGGGAGAGTGCCGATACGGG GAGAACTGTGTGTATCTCCACGGAGATTCTTGTGACATGTGTGGGCTGCAGGTCCTGCATCCAATGGATGCTGCCCAGAGATCGCAGCAT ATCAAAGACTTGATTAGAGACCAAGGATTTCGTGGTGATGGAGGATCAACCACAGGTTTGTCTGCTACCCCCCCTGCCTCATTACCTGGC TCACTAACTAACGTGAAAGCCTTACAGAAATCTCCAGGACCTCAGCGAGAAAGGAAGTCATCTTCATCCTCAGAAGACAGGAATCGAATG AAAACACTTGGTAGACGGGACTCGAGTGATGATTGGGAGATTCCTGATGGGCAGATTACAGTGGGACAAAGAATTGGATCTGGATCATTT GGAACAGTCTACAAGGGAAAGTGGCATGGTGATGTGGCAGTGAAAATGTTGAATGTGACAGCACCTACACCTCAGCAGTTACAAGCCTTC AAAAATGAAGTAGGAGTACTCAGGAAAACACGACATGTGAATATCCTACTCTTCATGGGCTATTCCACAAAGCCACAACTGGCTATTGTT ACCCAGTGGTGTGAGGGCTCCAGCTTGTATCACCATCTCCATATCATTGAGACCAAATTTGAGATGATCAAACTTATAGATATTGCACGA CAGACTGCACAGGGCATGGATTACTTACACGCCAAGTCAATCATCCACAGAGACCTCAAGAGTAATAATATATTTCTTCATGAAGACCTC ACAGTAAAAATAGGTGATTTTGGTCTAGCTACAGTGAAATCTCGATGGAGTGGGTCCCATCAGTTTGAACAGTTGTCTGGATCCATTTTG TGGATGGCACCAGAAGTCATCAGAATGCAAGATAAAAATCCATACAGCTTTCAGTCAGATGTATATGCATTTGGAATTGTTCTGTATGAA TTGATGACTGGACAGTTACCTTATTCAAACATCAACAACAGGGACCAGATAATTTTTATGGTGGGACGAGGATACCTGTCTCCAGATCTC AGTAAGGTACGGAGTAACTGTCCAAAAGCCATGAAGAGATTAATGGCAGAGTGCCTCAAAAAGAAAAGAGATGAGAGACCACTCTTTCCC CAAATTCTCGCCTCTATTGAGCTGCTGGCCCGCTCATTGCCAAAAATTCACCGCAGTGCATCAGAACCCTCCTTGAATCGGGCTGGTTTC CAAACAGAGGATTTTAGTCTATATGCTTGTGCTTCTCCAAAAACACCCATCCAGGCAGGGGGATATGGTGCGTTTCCTGTCCACTGAAAC AAATGAGTGAGAGAGTTCAGGAGAGTAGCAACAAAAGGAAAATAAATGAACATATGTTTGCTTATATGTTAAATTGAATAAAATACTCTC >54112_54112_2_MKRN1-BRAF_MKRN1_chr7_140158806_ENST00000255977_BRAF_chr7_140487384_ENST00000288602_length(amino acids)=643AA_BP=257 MAEAATPGTTATTSGAGAAAATAAAASPTPIPTVTAPSLGAGGGGGGSDGSGGGWTKQVTCRYFMHGVCKEGDNCRYSHDLSDSPYSVVC KYFQRGYCIYGDRCRYEHSKPLKQEEATATELTTKSSLAASSSLSSIVGPLVEMNTGEAESRNSNFATVGAGSEDWVNAIEFVPGQPYCG RTAPSCTEAPLQGSVTKEESEKEQTAVETKKQLCPYAAVGECRYGENCVYLHGDSCDMCGLQVLHPMDAAQRSQHIKDLIRDQGFRGDGG STTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVK MLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSII HRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRD QIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKT -------------------------------------------------------------- >54112_54112_3_MKRN1-BRAF_MKRN1_chr7_140158806_ENST00000443720_BRAF_chr7_140481493_ENST00000288602_length(transcript)=2031nt_BP=926nt GCTCAGATACGCGACGCGTAGCAGGCGGGGACCGAACGGGTGCCTCAGTGTCCTTCCCCTCCCCTCGCCTGGCCTCGCCGTCCTCTCCCC GCAGCCGGACCGGAACTATGTGATCCCGGAAGTTCCGGGGCCTTTGCTGTGTGGGATAAACAGTAATGGCGGAGGCTGCAACTCCCGGAA CAACAGCCACAACATCAGGAGCAGGAGCGGCAGCGGCGACGGCGGCAGCAGCCTCCCCCACCCCGATCCCCACAGTCACCGCCCCGTCCC TGGGGGCGGGCGGAGGGGGCGGCGGCAGCGACGGCAGCGGCGGCGGCTGGACTAAACAGGTCACCTGCAGGTATTTTATGCATGGGGTTT GTAAGGAAGGAGACAACTGTCGCTACTCGCATGACCTCTCTGACAGTCCGTATAGTGTAGTGTGCAAGTATTTTCAGCGAGGGTACTGTA TTTATGGAGACCGCTGCAGATATGAACATAGCAAACCATTGAAACAGGAAGAAGCAACTGCTACAGAGCTAACTACAAAGTCATCCCTTG CTGCTTCCTCAAGTCTCTCATCGATAGTTGGACCACTTGTTGAAATGAATACAGGCGAAGCTGAGTCAAGAAATTCAAACTTTGCAACTG TAGGAGCAGGTTCAGAGGACTGGGTGAATGCTATTGAGTTTGTTCCTGGGCAACCCTACTGTGGCCGTACTGCGCCTTCCTGCACTGAAG CACCCCTGCAGGGCTCAGTGACCAAGGAAGAATCAGAGAAAGAGCAAACCGCCGTGGAGACAAAGAAGCAGCTGTGCCCCTATGCTGCAG TGGGAGAGTGCCGATACGGGGAGAACTGTGTGTATCTCCACGGAGATTCTTGTGACATGTGTGGGCTGCAGGTCCTGCATCCAATGGATG CTGCCCAGAGATCGCAGCATATCAAAAAAACACTTGGTAGACGGGACTCGAGTGATGATTGGGAGATTCCTGATGGGCAGATTACAGTGG GACAAAGAATTGGATCTGGATCATTTGGAACAGTCTACAAGGGAAAGTGGCATGGTGATGTGGCAGTGAAAATGTTGAATGTGACAGCAC CTACACCTCAGCAGTTACAAGCCTTCAAAAATGAAGTAGGAGTACTCAGGAAAACACGACATGTGAATATCCTACTCTTCATGGGCTATT CCACAAAGCCACAACTGGCTATTGTTACCCAGTGGTGTGAGGGCTCCAGCTTGTATCACCATCTCCATATCATTGAGACCAAATTTGAGA TGATCAAACTTATAGATATTGCACGACAGACTGCACAGGGCATGGATTACTTACACGCCAAGTCAATCATCCACAGAGACCTCAAGAGTA ATAATATATTTCTTCATGAAGACCTCACAGTAAAAATAGGTGATTTTGGTCTAGCTACAGTGAAATCTCGATGGAGTGGGTCCCATCAGT TTGAACAGTTGTCTGGATCCATTTTGTGGATGGCACCAGAAGTCATCAGAATGCAAGATAAAAATCCATACAGCTTTCAGTCAGATGTAT ATGCATTTGGAATTGTTCTGTATGAATTGATGACTGGACAGTTACCTTATTCAAACATCAACAACAGGGACCAGATAATTTTTATGGTGG GACGAGGATACCTGTCTCCAGATCTCAGTAAGGTACGGAGTAACTGTCCAAAAGCCATGAAGAGATTAATGGCAGAGTGCCTCAAAAAGA AAAGAGATGAGAGACCACTCTTTCCCCAAATTCTCGCCTCTATTGAGCTGCTGGCCCGCTCATTGCCAAAAATTCACCGCAGTGCATCAG AACCCTCCTTGAATCGGGCTGGTTTCCAAACAGAGGATTTTAGTCTATATGCTTGTGCTTCTCCAAAAACACCCATCCAGGCAGGGGGAT ATGGTGCGTTTCCTGTCCACTGAAACAAATGAGTGAGAGAGTTCAGGAGAGTAGCAACAAAAGGAAAATAAATGAACATATGTTTGCTTA >54112_54112_3_MKRN1-BRAF_MKRN1_chr7_140158806_ENST00000443720_BRAF_chr7_140481493_ENST00000288602_length(amino acids)=585AA_BP=255 MAEAATPGTTATTSGAGAAAATAAAASPTPIPTVTAPSLGAGGGGGGSDGSGGGWTKQVTCRYFMHGVCKEGDNCRYSHDLSDSPYSVVC KYFQRGYCIYGDRCRYEHSKPLKQEEATATELTTKSSLAASSSLSSIVGPLVEMNTGEAESRNSNFATVGAGSEDWVNAIEFVPGQPYCG RTAPSCTEAPLQGSVTKEESEKEQTAVETKKQLCPYAAVGECRYGENCVYLHGDSCDMCGLQVLHPMDAAQRSQHIKKTLGRRDSSDDWE IPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHL HIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKN PYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSL -------------------------------------------------------------- >54112_54112_4_MKRN1-BRAF_MKRN1_chr7_140158806_ENST00000443720_BRAF_chr7_140487384_ENST00000288602_length(transcript)=2205nt_BP=926nt GCTCAGATACGCGACGCGTAGCAGGCGGGGACCGAACGGGTGCCTCAGTGTCCTTCCCCTCCCCTCGCCTGGCCTCGCCGTCCTCTCCCC GCAGCCGGACCGGAACTATGTGATCCCGGAAGTTCCGGGGCCTTTGCTGTGTGGGATAAACAGTAATGGCGGAGGCTGCAACTCCCGGAA CAACAGCCACAACATCAGGAGCAGGAGCGGCAGCGGCGACGGCGGCAGCAGCCTCCCCCACCCCGATCCCCACAGTCACCGCCCCGTCCC TGGGGGCGGGCGGAGGGGGCGGCGGCAGCGACGGCAGCGGCGGCGGCTGGACTAAACAGGTCACCTGCAGGTATTTTATGCATGGGGTTT GTAAGGAAGGAGACAACTGTCGCTACTCGCATGACCTCTCTGACAGTCCGTATAGTGTAGTGTGCAAGTATTTTCAGCGAGGGTACTGTA TTTATGGAGACCGCTGCAGATATGAACATAGCAAACCATTGAAACAGGAAGAAGCAACTGCTACAGAGCTAACTACAAAGTCATCCCTTG CTGCTTCCTCAAGTCTCTCATCGATAGTTGGACCACTTGTTGAAATGAATACAGGCGAAGCTGAGTCAAGAAATTCAAACTTTGCAACTG TAGGAGCAGGTTCAGAGGACTGGGTGAATGCTATTGAGTTTGTTCCTGGGCAACCCTACTGTGGCCGTACTGCGCCTTCCTGCACTGAAG CACCCCTGCAGGGCTCAGTGACCAAGGAAGAATCAGAGAAAGAGCAAACCGCCGTGGAGACAAAGAAGCAGCTGTGCCCCTATGCTGCAG TGGGAGAGTGCCGATACGGGGAGAACTGTGTGTATCTCCACGGAGATTCTTGTGACATGTGTGGGCTGCAGGTCCTGCATCCAATGGATG CTGCCCAGAGATCGCAGCATATCAAAGACTTGATTAGAGACCAAGGATTTCGTGGTGATGGAGGATCAACCACAGGTTTGTCTGCTACCC CCCCTGCCTCATTACCTGGCTCACTAACTAACGTGAAAGCCTTACAGAAATCTCCAGGACCTCAGCGAGAAAGGAAGTCATCTTCATCCT CAGAAGACAGGAATCGAATGAAAACACTTGGTAGACGGGACTCGAGTGATGATTGGGAGATTCCTGATGGGCAGATTACAGTGGGACAAA GAATTGGATCTGGATCATTTGGAACAGTCTACAAGGGAAAGTGGCATGGTGATGTGGCAGTGAAAATGTTGAATGTGACAGCACCTACAC CTCAGCAGTTACAAGCCTTCAAAAATGAAGTAGGAGTACTCAGGAAAACACGACATGTGAATATCCTACTCTTCATGGGCTATTCCACAA AGCCACAACTGGCTATTGTTACCCAGTGGTGTGAGGGCTCCAGCTTGTATCACCATCTCCATATCATTGAGACCAAATTTGAGATGATCA AACTTATAGATATTGCACGACAGACTGCACAGGGCATGGATTACTTACACGCCAAGTCAATCATCCACAGAGACCTCAAGAGTAATAATA TATTTCTTCATGAAGACCTCACAGTAAAAATAGGTGATTTTGGTCTAGCTACAGTGAAATCTCGATGGAGTGGGTCCCATCAGTTTGAAC AGTTGTCTGGATCCATTTTGTGGATGGCACCAGAAGTCATCAGAATGCAAGATAAAAATCCATACAGCTTTCAGTCAGATGTATATGCAT TTGGAATTGTTCTGTATGAATTGATGACTGGACAGTTACCTTATTCAAACATCAACAACAGGGACCAGATAATTTTTATGGTGGGACGAG GATACCTGTCTCCAGATCTCAGTAAGGTACGGAGTAACTGTCCAAAAGCCATGAAGAGATTAATGGCAGAGTGCCTCAAAAAGAAAAGAG ATGAGAGACCACTCTTTCCCCAAATTCTCGCCTCTATTGAGCTGCTGGCCCGCTCATTGCCAAAAATTCACCGCAGTGCATCAGAACCCT CCTTGAATCGGGCTGGTTTCCAAACAGAGGATTTTAGTCTATATGCTTGTGCTTCTCCAAAAACACCCATCCAGGCAGGGGGATATGGTG CGTTTCCTGTCCACTGAAACAAATGAGTGAGAGAGTTCAGGAGAGTAGCAACAAAAGGAAAATAAATGAACATATGTTTGCTTATATGTT >54112_54112_4_MKRN1-BRAF_MKRN1_chr7_140158806_ENST00000443720_BRAF_chr7_140487384_ENST00000288602_length(amino acids)=643AA_BP=257 MAEAATPGTTATTSGAGAAAATAAAASPTPIPTVTAPSLGAGGGGGGSDGSGGGWTKQVTCRYFMHGVCKEGDNCRYSHDLSDSPYSVVC KYFQRGYCIYGDRCRYEHSKPLKQEEATATELTTKSSLAASSSLSSIVGPLVEMNTGEAESRNSNFATVGAGSEDWVNAIEFVPGQPYCG RTAPSCTEAPLQGSVTKEESEKEQTAVETKKQLCPYAAVGECRYGENCVYLHGDSCDMCGLQVLHPMDAAQRSQHIKDLIRDQGFRGDGG STTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVK MLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSII HRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRD QIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKT -------------------------------------------------------------- >54112_54112_5_MKRN1-BRAF_MKRN1_chr7_140158806_ENST00000474576_BRAF_chr7_140481493_ENST00000288602_length(transcript)=1839nt_BP=734nt ACTGCGTCAACCCCCGCTGGGCCGCGGAGCCCTCAGCGCTGTCCGCGGAGGCCTGGCGGTGCGCGATTACTGCGGAGCCGCGGGGCTGCA CCGCCGCTTACACTTCCCTGAGCGCTGCCTGAGCTGGCTGCGAGCGCATCGGGGAGAGGTATTTTATGCATGGGGTTTGTAAGGAAGGAG ACAACTGTCGCTACTCGCATGACCTCTCTGACAGTCCGTATAGTGTAGTGTGCAAGTATTTTCAGCGAGGGTACTGTATTTATGGAGACC GCTGCAGATATGAACATAGCAAACCATTGAAACAGGAAGAAGCAACTGCTACAGAGCTAACTACAAAGTCATCCCTTGCTGCTTCCTCAA GTCTCTCATCGATAGTTGGACCACTTGTTGAAATGAATACAGGCGAAGCTGAGTCAAGAAATTCAAACTTTGCAACTGTAGGAGCAGGTT CAGAGGACTGGGTGAATGCTATTGAGTTTGTTCCTGGGCAACCCTACTGTGGCCGTACTGCGCCTTCCTGCACTGAAGCACCCCTGCAGG GCTCAGTGACCAAGGAAGAATCAGAGAAAGAGCAAACCGCCGTGGAGACAAAGAAGCAGCTGTGCCCCTATGCTGCAGTGGGAGAGTGCC GATACGGGGAGAACTGTGTGTATCTCCACGGAGATTCTTGTGACATGTGTGGGCTGCAGGTCCTGCATCCAATGGATGCTGCCCAGAGAT CGCAGCATATCAAAAAAACACTTGGTAGACGGGACTCGAGTGATGATTGGGAGATTCCTGATGGGCAGATTACAGTGGGACAAAGAATTG GATCTGGATCATTTGGAACAGTCTACAAGGGAAAGTGGCATGGTGATGTGGCAGTGAAAATGTTGAATGTGACAGCACCTACACCTCAGC AGTTACAAGCCTTCAAAAATGAAGTAGGAGTACTCAGGAAAACACGACATGTGAATATCCTACTCTTCATGGGCTATTCCACAAAGCCAC AACTGGCTATTGTTACCCAGTGGTGTGAGGGCTCCAGCTTGTATCACCATCTCCATATCATTGAGACCAAATTTGAGATGATCAAACTTA TAGATATTGCACGACAGACTGCACAGGGCATGGATTACTTACACGCCAAGTCAATCATCCACAGAGACCTCAAGAGTAATAATATATTTC TTCATGAAGACCTCACAGTAAAAATAGGTGATTTTGGTCTAGCTACAGTGAAATCTCGATGGAGTGGGTCCCATCAGTTTGAACAGTTGT CTGGATCCATTTTGTGGATGGCACCAGAAGTCATCAGAATGCAAGATAAAAATCCATACAGCTTTCAGTCAGATGTATATGCATTTGGAA TTGTTCTGTATGAATTGATGACTGGACAGTTACCTTATTCAAACATCAACAACAGGGACCAGATAATTTTTATGGTGGGACGAGGATACC TGTCTCCAGATCTCAGTAAGGTACGGAGTAACTGTCCAAAAGCCATGAAGAGATTAATGGCAGAGTGCCTCAAAAAGAAAAGAGATGAGA GACCACTCTTTCCCCAAATTCTCGCCTCTATTGAGCTGCTGGCCCGCTCATTGCCAAAAATTCACCGCAGTGCATCAGAACCCTCCTTGA ATCGGGCTGGTTTCCAAACAGAGGATTTTAGTCTATATGCTTGTGCTTCTCCAAAAACACCCATCCAGGCAGGGGGATATGGTGCGTTTC CTGTCCACTGAAACAAATGAGTGAGAGAGTTCAGGAGAGTAGCAACAAAAGGAAAATAAATGAACATATGTTTGCTTATATGTTAAATTG >54112_54112_5_MKRN1-BRAF_MKRN1_chr7_140158806_ENST00000474576_BRAF_chr7_140481493_ENST00000288602_length(amino acids)=521AA_BP=191 MHGVCKEGDNCRYSHDLSDSPYSVVCKYFQRGYCIYGDRCRYEHSKPLKQEEATATELTTKSSLAASSSLSSIVGPLVEMNTGEAESRNS NFATVGAGSEDWVNAIEFVPGQPYCGRTAPSCTEAPLQGSVTKEESEKEQTAVETKKQLCPYAAVGECRYGENCVYLHGDSCDMCGLQVL HPMDAAQRSQHIKKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILL FMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWS GSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAE -------------------------------------------------------------- >54112_54112_6_MKRN1-BRAF_MKRN1_chr7_140158806_ENST00000474576_BRAF_chr7_140487384_ENST00000288602_length(transcript)=2013nt_BP=734nt ACTGCGTCAACCCCCGCTGGGCCGCGGAGCCCTCAGCGCTGTCCGCGGAGGCCTGGCGGTGCGCGATTACTGCGGAGCCGCGGGGCTGCA CCGCCGCTTACACTTCCCTGAGCGCTGCCTGAGCTGGCTGCGAGCGCATCGGGGAGAGGTATTTTATGCATGGGGTTTGTAAGGAAGGAG ACAACTGTCGCTACTCGCATGACCTCTCTGACAGTCCGTATAGTGTAGTGTGCAAGTATTTTCAGCGAGGGTACTGTATTTATGGAGACC GCTGCAGATATGAACATAGCAAACCATTGAAACAGGAAGAAGCAACTGCTACAGAGCTAACTACAAAGTCATCCCTTGCTGCTTCCTCAA GTCTCTCATCGATAGTTGGACCACTTGTTGAAATGAATACAGGCGAAGCTGAGTCAAGAAATTCAAACTTTGCAACTGTAGGAGCAGGTT CAGAGGACTGGGTGAATGCTATTGAGTTTGTTCCTGGGCAACCCTACTGTGGCCGTACTGCGCCTTCCTGCACTGAAGCACCCCTGCAGG GCTCAGTGACCAAGGAAGAATCAGAGAAAGAGCAAACCGCCGTGGAGACAAAGAAGCAGCTGTGCCCCTATGCTGCAGTGGGAGAGTGCC GATACGGGGAGAACTGTGTGTATCTCCACGGAGATTCTTGTGACATGTGTGGGCTGCAGGTCCTGCATCCAATGGATGCTGCCCAGAGAT CGCAGCATATCAAAGACTTGATTAGAGACCAAGGATTTCGTGGTGATGGAGGATCAACCACAGGTTTGTCTGCTACCCCCCCTGCCTCAT TACCTGGCTCACTAACTAACGTGAAAGCCTTACAGAAATCTCCAGGACCTCAGCGAGAAAGGAAGTCATCTTCATCCTCAGAAGACAGGA ATCGAATGAAAACACTTGGTAGACGGGACTCGAGTGATGATTGGGAGATTCCTGATGGGCAGATTACAGTGGGACAAAGAATTGGATCTG GATCATTTGGAACAGTCTACAAGGGAAAGTGGCATGGTGATGTGGCAGTGAAAATGTTGAATGTGACAGCACCTACACCTCAGCAGTTAC AAGCCTTCAAAAATGAAGTAGGAGTACTCAGGAAAACACGACATGTGAATATCCTACTCTTCATGGGCTATTCCACAAAGCCACAACTGG CTATTGTTACCCAGTGGTGTGAGGGCTCCAGCTTGTATCACCATCTCCATATCATTGAGACCAAATTTGAGATGATCAAACTTATAGATA TTGCACGACAGACTGCACAGGGCATGGATTACTTACACGCCAAGTCAATCATCCACAGAGACCTCAAGAGTAATAATATATTTCTTCATG AAGACCTCACAGTAAAAATAGGTGATTTTGGTCTAGCTACAGTGAAATCTCGATGGAGTGGGTCCCATCAGTTTGAACAGTTGTCTGGAT CCATTTTGTGGATGGCACCAGAAGTCATCAGAATGCAAGATAAAAATCCATACAGCTTTCAGTCAGATGTATATGCATTTGGAATTGTTC TGTATGAATTGATGACTGGACAGTTACCTTATTCAAACATCAACAACAGGGACCAGATAATTTTTATGGTGGGACGAGGATACCTGTCTC CAGATCTCAGTAAGGTACGGAGTAACTGTCCAAAAGCCATGAAGAGATTAATGGCAGAGTGCCTCAAAAAGAAAAGAGATGAGAGACCAC TCTTTCCCCAAATTCTCGCCTCTATTGAGCTGCTGGCCCGCTCATTGCCAAAAATTCACCGCAGTGCATCAGAACCCTCCTTGAATCGGG CTGGTTTCCAAACAGAGGATTTTAGTCTATATGCTTGTGCTTCTCCAAAAACACCCATCCAGGCAGGGGGATATGGTGCGTTTCCTGTCC ACTGAAACAAATGAGTGAGAGAGTTCAGGAGAGTAGCAACAAAAGGAAAATAAATGAACATATGTTTGCTTATATGTTAAATTGAATAAA >54112_54112_6_MKRN1-BRAF_MKRN1_chr7_140158806_ENST00000474576_BRAF_chr7_140487384_ENST00000288602_length(amino acids)=579AA_BP=193 MHGVCKEGDNCRYSHDLSDSPYSVVCKYFQRGYCIYGDRCRYEHSKPLKQEEATATELTTKSSLAASSSLSSIVGPLVEMNTGEAESRNS NFATVGAGSEDWVNAIEFVPGQPYCGRTAPSCTEAPLQGSVTKEESEKEQTAVETKKQLCPYAAVGECRYGENCVYLHGDSCDMCGLQVL HPMDAAQRSQHIKDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQI TVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETK FEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQS DVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRS -------------------------------------------------------------- >54112_54112_7_MKRN1-BRAF_MKRN1_chr7_140158807_ENST00000255977_BRAF_chr7_140481493_ENST00000288602_length(transcript)=2101nt_BP=996nt ACCAATGAGCGGCGCCGTGGGCGGGCCGCGGGCGCGCATGCTCTGGGCCCGCAGTTGAAGTGGCGAGAGCGCTCAGATACGCGACGCGTA GCAGGCGGGGACCGAACGGGTGCCTCAGTGTCCTTCCCCTCCCCTCGCCTGGCCTCGCCGTCCTCTCCCCGCAGCCGGACCGGAACTATG TGATCCCGGAAGTTCCGGGGCCTTTGCTGTGTGGGATAAACAGTAATGGCGGAGGCTGCAACTCCCGGAACAACAGCCACAACATCAGGA GCAGGAGCGGCAGCGGCGACGGCGGCAGCAGCCTCCCCCACCCCGATCCCCACAGTCACCGCCCCGTCCCTGGGGGCGGGCGGAGGGGGC GGCGGCAGCGACGGCAGCGGCGGCGGCTGGACTAAACAGGTCACCTGCAGGTATTTTATGCATGGGGTTTGTAAGGAAGGAGACAACTGT CGCTACTCGCATGACCTCTCTGACAGTCCGTATAGTGTAGTGTGCAAGTATTTTCAGCGAGGGTACTGTATTTATGGAGACCGCTGCAGA TATGAACATAGCAAACCATTGAAACAGGAAGAAGCAACTGCTACAGAGCTAACTACAAAGTCATCCCTTGCTGCTTCCTCAAGTCTCTCA TCGATAGTTGGACCACTTGTTGAAATGAATACAGGCGAAGCTGAGTCAAGAAATTCAAACTTTGCAACTGTAGGAGCAGGTTCAGAGGAC TGGGTGAATGCTATTGAGTTTGTTCCTGGGCAACCCTACTGTGGCCGTACTGCGCCTTCCTGCACTGAAGCACCCCTGCAGGGCTCAGTG ACCAAGGAAGAATCAGAGAAAGAGCAAACCGCCGTGGAGACAAAGAAGCAGCTGTGCCCCTATGCTGCAGTGGGAGAGTGCCGATACGGG GAGAACTGTGTGTATCTCCACGGAGATTCTTGTGACATGTGTGGGCTGCAGGTCCTGCATCCAATGGATGCTGCCCAGAGATCGCAGCAT ATCAAAAAAACACTTGGTAGACGGGACTCGAGTGATGATTGGGAGATTCCTGATGGGCAGATTACAGTGGGACAAAGAATTGGATCTGGA TCATTTGGAACAGTCTACAAGGGAAAGTGGCATGGTGATGTGGCAGTGAAAATGTTGAATGTGACAGCACCTACACCTCAGCAGTTACAA GCCTTCAAAAATGAAGTAGGAGTACTCAGGAAAACACGACATGTGAATATCCTACTCTTCATGGGCTATTCCACAAAGCCACAACTGGCT ATTGTTACCCAGTGGTGTGAGGGCTCCAGCTTGTATCACCATCTCCATATCATTGAGACCAAATTTGAGATGATCAAACTTATAGATATT GCACGACAGACTGCACAGGGCATGGATTACTTACACGCCAAGTCAATCATCCACAGAGACCTCAAGAGTAATAATATATTTCTTCATGAA GACCTCACAGTAAAAATAGGTGATTTTGGTCTAGCTACAGTGAAATCTCGATGGAGTGGGTCCCATCAGTTTGAACAGTTGTCTGGATCC ATTTTGTGGATGGCACCAGAAGTCATCAGAATGCAAGATAAAAATCCATACAGCTTTCAGTCAGATGTATATGCATTTGGAATTGTTCTG TATGAATTGATGACTGGACAGTTACCTTATTCAAACATCAACAACAGGGACCAGATAATTTTTATGGTGGGACGAGGATACCTGTCTCCA GATCTCAGTAAGGTACGGAGTAACTGTCCAAAAGCCATGAAGAGATTAATGGCAGAGTGCCTCAAAAAGAAAAGAGATGAGAGACCACTC TTTCCCCAAATTCTCGCCTCTATTGAGCTGCTGGCCCGCTCATTGCCAAAAATTCACCGCAGTGCATCAGAACCCTCCTTGAATCGGGCT GGTTTCCAAACAGAGGATTTTAGTCTATATGCTTGTGCTTCTCCAAAAACACCCATCCAGGCAGGGGGATATGGTGCGTTTCCTGTCCAC TGAAACAAATGAGTGAGAGAGTTCAGGAGAGTAGCAACAAAAGGAAAATAAATGAACATATGTTTGCTTATATGTTAAATTGAATAAAAT >54112_54112_7_MKRN1-BRAF_MKRN1_chr7_140158807_ENST00000255977_BRAF_chr7_140481493_ENST00000288602_length(amino acids)=585AA_BP=255 MAEAATPGTTATTSGAGAAAATAAAASPTPIPTVTAPSLGAGGGGGGSDGSGGGWTKQVTCRYFMHGVCKEGDNCRYSHDLSDSPYSVVC KYFQRGYCIYGDRCRYEHSKPLKQEEATATELTTKSSLAASSSLSSIVGPLVEMNTGEAESRNSNFATVGAGSEDWVNAIEFVPGQPYCG RTAPSCTEAPLQGSVTKEESEKEQTAVETKKQLCPYAAVGECRYGENCVYLHGDSCDMCGLQVLHPMDAAQRSQHIKKTLGRRDSSDDWE IPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHL HIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKN PYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSL -------------------------------------------------------------- >54112_54112_8_MKRN1-BRAF_MKRN1_chr7_140158807_ENST00000255977_BRAF_chr7_140487384_ENST00000288602_length(transcript)=2275nt_BP=996nt ACCAATGAGCGGCGCCGTGGGCGGGCCGCGGGCGCGCATGCTCTGGGCCCGCAGTTGAAGTGGCGAGAGCGCTCAGATACGCGACGCGTA GCAGGCGGGGACCGAACGGGTGCCTCAGTGTCCTTCCCCTCCCCTCGCCTGGCCTCGCCGTCCTCTCCCCGCAGCCGGACCGGAACTATG TGATCCCGGAAGTTCCGGGGCCTTTGCTGTGTGGGATAAACAGTAATGGCGGAGGCTGCAACTCCCGGAACAACAGCCACAACATCAGGA GCAGGAGCGGCAGCGGCGACGGCGGCAGCAGCCTCCCCCACCCCGATCCCCACAGTCACCGCCCCGTCCCTGGGGGCGGGCGGAGGGGGC GGCGGCAGCGACGGCAGCGGCGGCGGCTGGACTAAACAGGTCACCTGCAGGTATTTTATGCATGGGGTTTGTAAGGAAGGAGACAACTGT CGCTACTCGCATGACCTCTCTGACAGTCCGTATAGTGTAGTGTGCAAGTATTTTCAGCGAGGGTACTGTATTTATGGAGACCGCTGCAGA TATGAACATAGCAAACCATTGAAACAGGAAGAAGCAACTGCTACAGAGCTAACTACAAAGTCATCCCTTGCTGCTTCCTCAAGTCTCTCA TCGATAGTTGGACCACTTGTTGAAATGAATACAGGCGAAGCTGAGTCAAGAAATTCAAACTTTGCAACTGTAGGAGCAGGTTCAGAGGAC TGGGTGAATGCTATTGAGTTTGTTCCTGGGCAACCCTACTGTGGCCGTACTGCGCCTTCCTGCACTGAAGCACCCCTGCAGGGCTCAGTG ACCAAGGAAGAATCAGAGAAAGAGCAAACCGCCGTGGAGACAAAGAAGCAGCTGTGCCCCTATGCTGCAGTGGGAGAGTGCCGATACGGG GAGAACTGTGTGTATCTCCACGGAGATTCTTGTGACATGTGTGGGCTGCAGGTCCTGCATCCAATGGATGCTGCCCAGAGATCGCAGCAT ATCAAAGACTTGATTAGAGACCAAGGATTTCGTGGTGATGGAGGATCAACCACAGGTTTGTCTGCTACCCCCCCTGCCTCATTACCTGGC TCACTAACTAACGTGAAAGCCTTACAGAAATCTCCAGGACCTCAGCGAGAAAGGAAGTCATCTTCATCCTCAGAAGACAGGAATCGAATG AAAACACTTGGTAGACGGGACTCGAGTGATGATTGGGAGATTCCTGATGGGCAGATTACAGTGGGACAAAGAATTGGATCTGGATCATTT GGAACAGTCTACAAGGGAAAGTGGCATGGTGATGTGGCAGTGAAAATGTTGAATGTGACAGCACCTACACCTCAGCAGTTACAAGCCTTC AAAAATGAAGTAGGAGTACTCAGGAAAACACGACATGTGAATATCCTACTCTTCATGGGCTATTCCACAAAGCCACAACTGGCTATTGTT ACCCAGTGGTGTGAGGGCTCCAGCTTGTATCACCATCTCCATATCATTGAGACCAAATTTGAGATGATCAAACTTATAGATATTGCACGA CAGACTGCACAGGGCATGGATTACTTACACGCCAAGTCAATCATCCACAGAGACCTCAAGAGTAATAATATATTTCTTCATGAAGACCTC ACAGTAAAAATAGGTGATTTTGGTCTAGCTACAGTGAAATCTCGATGGAGTGGGTCCCATCAGTTTGAACAGTTGTCTGGATCCATTTTG TGGATGGCACCAGAAGTCATCAGAATGCAAGATAAAAATCCATACAGCTTTCAGTCAGATGTATATGCATTTGGAATTGTTCTGTATGAA TTGATGACTGGACAGTTACCTTATTCAAACATCAACAACAGGGACCAGATAATTTTTATGGTGGGACGAGGATACCTGTCTCCAGATCTC AGTAAGGTACGGAGTAACTGTCCAAAAGCCATGAAGAGATTAATGGCAGAGTGCCTCAAAAAGAAAAGAGATGAGAGACCACTCTTTCCC CAAATTCTCGCCTCTATTGAGCTGCTGGCCCGCTCATTGCCAAAAATTCACCGCAGTGCATCAGAACCCTCCTTGAATCGGGCTGGTTTC CAAACAGAGGATTTTAGTCTATATGCTTGTGCTTCTCCAAAAACACCCATCCAGGCAGGGGGATATGGTGCGTTTCCTGTCCACTGAAAC AAATGAGTGAGAGAGTTCAGGAGAGTAGCAACAAAAGGAAAATAAATGAACATATGTTTGCTTATATGTTAAATTGAATAAAATACTCTC >54112_54112_8_MKRN1-BRAF_MKRN1_chr7_140158807_ENST00000255977_BRAF_chr7_140487384_ENST00000288602_length(amino acids)=643AA_BP=257 MAEAATPGTTATTSGAGAAAATAAAASPTPIPTVTAPSLGAGGGGGGSDGSGGGWTKQVTCRYFMHGVCKEGDNCRYSHDLSDSPYSVVC KYFQRGYCIYGDRCRYEHSKPLKQEEATATELTTKSSLAASSSLSSIVGPLVEMNTGEAESRNSNFATVGAGSEDWVNAIEFVPGQPYCG RTAPSCTEAPLQGSVTKEESEKEQTAVETKKQLCPYAAVGECRYGENCVYLHGDSCDMCGLQVLHPMDAAQRSQHIKDLIRDQGFRGDGG STTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVK MLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSII HRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRD QIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKT -------------------------------------------------------------- >54112_54112_9_MKRN1-BRAF_MKRN1_chr7_140158807_ENST00000443720_BRAF_chr7_140481493_ENST00000288602_length(transcript)=2031nt_BP=926nt GCTCAGATACGCGACGCGTAGCAGGCGGGGACCGAACGGGTGCCTCAGTGTCCTTCCCCTCCCCTCGCCTGGCCTCGCCGTCCTCTCCCC GCAGCCGGACCGGAACTATGTGATCCCGGAAGTTCCGGGGCCTTTGCTGTGTGGGATAAACAGTAATGGCGGAGGCTGCAACTCCCGGAA CAACAGCCACAACATCAGGAGCAGGAGCGGCAGCGGCGACGGCGGCAGCAGCCTCCCCCACCCCGATCCCCACAGTCACCGCCCCGTCCC TGGGGGCGGGCGGAGGGGGCGGCGGCAGCGACGGCAGCGGCGGCGGCTGGACTAAACAGGTCACCTGCAGGTATTTTATGCATGGGGTTT GTAAGGAAGGAGACAACTGTCGCTACTCGCATGACCTCTCTGACAGTCCGTATAGTGTAGTGTGCAAGTATTTTCAGCGAGGGTACTGTA TTTATGGAGACCGCTGCAGATATGAACATAGCAAACCATTGAAACAGGAAGAAGCAACTGCTACAGAGCTAACTACAAAGTCATCCCTTG CTGCTTCCTCAAGTCTCTCATCGATAGTTGGACCACTTGTTGAAATGAATACAGGCGAAGCTGAGTCAAGAAATTCAAACTTTGCAACTG TAGGAGCAGGTTCAGAGGACTGGGTGAATGCTATTGAGTTTGTTCCTGGGCAACCCTACTGTGGCCGTACTGCGCCTTCCTGCACTGAAG CACCCCTGCAGGGCTCAGTGACCAAGGAAGAATCAGAGAAAGAGCAAACCGCCGTGGAGACAAAGAAGCAGCTGTGCCCCTATGCTGCAG TGGGAGAGTGCCGATACGGGGAGAACTGTGTGTATCTCCACGGAGATTCTTGTGACATGTGTGGGCTGCAGGTCCTGCATCCAATGGATG CTGCCCAGAGATCGCAGCATATCAAAAAAACACTTGGTAGACGGGACTCGAGTGATGATTGGGAGATTCCTGATGGGCAGATTACAGTGG GACAAAGAATTGGATCTGGATCATTTGGAACAGTCTACAAGGGAAAGTGGCATGGTGATGTGGCAGTGAAAATGTTGAATGTGACAGCAC CTACACCTCAGCAGTTACAAGCCTTCAAAAATGAAGTAGGAGTACTCAGGAAAACACGACATGTGAATATCCTACTCTTCATGGGCTATT CCACAAAGCCACAACTGGCTATTGTTACCCAGTGGTGTGAGGGCTCCAGCTTGTATCACCATCTCCATATCATTGAGACCAAATTTGAGA TGATCAAACTTATAGATATTGCACGACAGACTGCACAGGGCATGGATTACTTACACGCCAAGTCAATCATCCACAGAGACCTCAAGAGTA ATAATATATTTCTTCATGAAGACCTCACAGTAAAAATAGGTGATTTTGGTCTAGCTACAGTGAAATCTCGATGGAGTGGGTCCCATCAGT TTGAACAGTTGTCTGGATCCATTTTGTGGATGGCACCAGAAGTCATCAGAATGCAAGATAAAAATCCATACAGCTTTCAGTCAGATGTAT ATGCATTTGGAATTGTTCTGTATGAATTGATGACTGGACAGTTACCTTATTCAAACATCAACAACAGGGACCAGATAATTTTTATGGTGG GACGAGGATACCTGTCTCCAGATCTCAGTAAGGTACGGAGTAACTGTCCAAAAGCCATGAAGAGATTAATGGCAGAGTGCCTCAAAAAGA AAAGAGATGAGAGACCACTCTTTCCCCAAATTCTCGCCTCTATTGAGCTGCTGGCCCGCTCATTGCCAAAAATTCACCGCAGTGCATCAG AACCCTCCTTGAATCGGGCTGGTTTCCAAACAGAGGATTTTAGTCTATATGCTTGTGCTTCTCCAAAAACACCCATCCAGGCAGGGGGAT ATGGTGCGTTTCCTGTCCACTGAAACAAATGAGTGAGAGAGTTCAGGAGAGTAGCAACAAAAGGAAAATAAATGAACATATGTTTGCTTA >54112_54112_9_MKRN1-BRAF_MKRN1_chr7_140158807_ENST00000443720_BRAF_chr7_140481493_ENST00000288602_length(amino acids)=585AA_BP=255 MAEAATPGTTATTSGAGAAAATAAAASPTPIPTVTAPSLGAGGGGGGSDGSGGGWTKQVTCRYFMHGVCKEGDNCRYSHDLSDSPYSVVC KYFQRGYCIYGDRCRYEHSKPLKQEEATATELTTKSSLAASSSLSSIVGPLVEMNTGEAESRNSNFATVGAGSEDWVNAIEFVPGQPYCG RTAPSCTEAPLQGSVTKEESEKEQTAVETKKQLCPYAAVGECRYGENCVYLHGDSCDMCGLQVLHPMDAAQRSQHIKKTLGRRDSSDDWE IPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHL HIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKN PYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSL -------------------------------------------------------------- >54112_54112_10_MKRN1-BRAF_MKRN1_chr7_140158807_ENST00000443720_BRAF_chr7_140487384_ENST00000288602_length(transcript)=2205nt_BP=926nt GCTCAGATACGCGACGCGTAGCAGGCGGGGACCGAACGGGTGCCTCAGTGTCCTTCCCCTCCCCTCGCCTGGCCTCGCCGTCCTCTCCCC GCAGCCGGACCGGAACTATGTGATCCCGGAAGTTCCGGGGCCTTTGCTGTGTGGGATAAACAGTAATGGCGGAGGCTGCAACTCCCGGAA CAACAGCCACAACATCAGGAGCAGGAGCGGCAGCGGCGACGGCGGCAGCAGCCTCCCCCACCCCGATCCCCACAGTCACCGCCCCGTCCC TGGGGGCGGGCGGAGGGGGCGGCGGCAGCGACGGCAGCGGCGGCGGCTGGACTAAACAGGTCACCTGCAGGTATTTTATGCATGGGGTTT GTAAGGAAGGAGACAACTGTCGCTACTCGCATGACCTCTCTGACAGTCCGTATAGTGTAGTGTGCAAGTATTTTCAGCGAGGGTACTGTA TTTATGGAGACCGCTGCAGATATGAACATAGCAAACCATTGAAACAGGAAGAAGCAACTGCTACAGAGCTAACTACAAAGTCATCCCTTG CTGCTTCCTCAAGTCTCTCATCGATAGTTGGACCACTTGTTGAAATGAATACAGGCGAAGCTGAGTCAAGAAATTCAAACTTTGCAACTG TAGGAGCAGGTTCAGAGGACTGGGTGAATGCTATTGAGTTTGTTCCTGGGCAACCCTACTGTGGCCGTACTGCGCCTTCCTGCACTGAAG CACCCCTGCAGGGCTCAGTGACCAAGGAAGAATCAGAGAAAGAGCAAACCGCCGTGGAGACAAAGAAGCAGCTGTGCCCCTATGCTGCAG TGGGAGAGTGCCGATACGGGGAGAACTGTGTGTATCTCCACGGAGATTCTTGTGACATGTGTGGGCTGCAGGTCCTGCATCCAATGGATG CTGCCCAGAGATCGCAGCATATCAAAGACTTGATTAGAGACCAAGGATTTCGTGGTGATGGAGGATCAACCACAGGTTTGTCTGCTACCC CCCCTGCCTCATTACCTGGCTCACTAACTAACGTGAAAGCCTTACAGAAATCTCCAGGACCTCAGCGAGAAAGGAAGTCATCTTCATCCT CAGAAGACAGGAATCGAATGAAAACACTTGGTAGACGGGACTCGAGTGATGATTGGGAGATTCCTGATGGGCAGATTACAGTGGGACAAA GAATTGGATCTGGATCATTTGGAACAGTCTACAAGGGAAAGTGGCATGGTGATGTGGCAGTGAAAATGTTGAATGTGACAGCACCTACAC CTCAGCAGTTACAAGCCTTCAAAAATGAAGTAGGAGTACTCAGGAAAACACGACATGTGAATATCCTACTCTTCATGGGCTATTCCACAA AGCCACAACTGGCTATTGTTACCCAGTGGTGTGAGGGCTCCAGCTTGTATCACCATCTCCATATCATTGAGACCAAATTTGAGATGATCA AACTTATAGATATTGCACGACAGACTGCACAGGGCATGGATTACTTACACGCCAAGTCAATCATCCACAGAGACCTCAAGAGTAATAATA TATTTCTTCATGAAGACCTCACAGTAAAAATAGGTGATTTTGGTCTAGCTACAGTGAAATCTCGATGGAGTGGGTCCCATCAGTTTGAAC AGTTGTCTGGATCCATTTTGTGGATGGCACCAGAAGTCATCAGAATGCAAGATAAAAATCCATACAGCTTTCAGTCAGATGTATATGCAT TTGGAATTGTTCTGTATGAATTGATGACTGGACAGTTACCTTATTCAAACATCAACAACAGGGACCAGATAATTTTTATGGTGGGACGAG GATACCTGTCTCCAGATCTCAGTAAGGTACGGAGTAACTGTCCAAAAGCCATGAAGAGATTAATGGCAGAGTGCCTCAAAAAGAAAAGAG ATGAGAGACCACTCTTTCCCCAAATTCTCGCCTCTATTGAGCTGCTGGCCCGCTCATTGCCAAAAATTCACCGCAGTGCATCAGAACCCT CCTTGAATCGGGCTGGTTTCCAAACAGAGGATTTTAGTCTATATGCTTGTGCTTCTCCAAAAACACCCATCCAGGCAGGGGGATATGGTG CGTTTCCTGTCCACTGAAACAAATGAGTGAGAGAGTTCAGGAGAGTAGCAACAAAAGGAAAATAAATGAACATATGTTTGCTTATATGTT >54112_54112_10_MKRN1-BRAF_MKRN1_chr7_140158807_ENST00000443720_BRAF_chr7_140487384_ENST00000288602_length(amino acids)=643AA_BP=257 MAEAATPGTTATTSGAGAAAATAAAASPTPIPTVTAPSLGAGGGGGGSDGSGGGWTKQVTCRYFMHGVCKEGDNCRYSHDLSDSPYSVVC KYFQRGYCIYGDRCRYEHSKPLKQEEATATELTTKSSLAASSSLSSIVGPLVEMNTGEAESRNSNFATVGAGSEDWVNAIEFVPGQPYCG RTAPSCTEAPLQGSVTKEESEKEQTAVETKKQLCPYAAVGECRYGENCVYLHGDSCDMCGLQVLHPMDAAQRSQHIKDLIRDQGFRGDGG STTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVK MLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSII HRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRD QIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKT -------------------------------------------------------------- >54112_54112_11_MKRN1-BRAF_MKRN1_chr7_140158807_ENST00000474576_BRAF_chr7_140481493_ENST00000288602_length(transcript)=1839nt_BP=734nt ACTGCGTCAACCCCCGCTGGGCCGCGGAGCCCTCAGCGCTGTCCGCGGAGGCCTGGCGGTGCGCGATTACTGCGGAGCCGCGGGGCTGCA CCGCCGCTTACACTTCCCTGAGCGCTGCCTGAGCTGGCTGCGAGCGCATCGGGGAGAGGTATTTTATGCATGGGGTTTGTAAGGAAGGAG ACAACTGTCGCTACTCGCATGACCTCTCTGACAGTCCGTATAGTGTAGTGTGCAAGTATTTTCAGCGAGGGTACTGTATTTATGGAGACC GCTGCAGATATGAACATAGCAAACCATTGAAACAGGAAGAAGCAACTGCTACAGAGCTAACTACAAAGTCATCCCTTGCTGCTTCCTCAA GTCTCTCATCGATAGTTGGACCACTTGTTGAAATGAATACAGGCGAAGCTGAGTCAAGAAATTCAAACTTTGCAACTGTAGGAGCAGGTT CAGAGGACTGGGTGAATGCTATTGAGTTTGTTCCTGGGCAACCCTACTGTGGCCGTACTGCGCCTTCCTGCACTGAAGCACCCCTGCAGG GCTCAGTGACCAAGGAAGAATCAGAGAAAGAGCAAACCGCCGTGGAGACAAAGAAGCAGCTGTGCCCCTATGCTGCAGTGGGAGAGTGCC GATACGGGGAGAACTGTGTGTATCTCCACGGAGATTCTTGTGACATGTGTGGGCTGCAGGTCCTGCATCCAATGGATGCTGCCCAGAGAT CGCAGCATATCAAAAAAACACTTGGTAGACGGGACTCGAGTGATGATTGGGAGATTCCTGATGGGCAGATTACAGTGGGACAAAGAATTG GATCTGGATCATTTGGAACAGTCTACAAGGGAAAGTGGCATGGTGATGTGGCAGTGAAAATGTTGAATGTGACAGCACCTACACCTCAGC AGTTACAAGCCTTCAAAAATGAAGTAGGAGTACTCAGGAAAACACGACATGTGAATATCCTACTCTTCATGGGCTATTCCACAAAGCCAC AACTGGCTATTGTTACCCAGTGGTGTGAGGGCTCCAGCTTGTATCACCATCTCCATATCATTGAGACCAAATTTGAGATGATCAAACTTA TAGATATTGCACGACAGACTGCACAGGGCATGGATTACTTACACGCCAAGTCAATCATCCACAGAGACCTCAAGAGTAATAATATATTTC TTCATGAAGACCTCACAGTAAAAATAGGTGATTTTGGTCTAGCTACAGTGAAATCTCGATGGAGTGGGTCCCATCAGTTTGAACAGTTGT CTGGATCCATTTTGTGGATGGCACCAGAAGTCATCAGAATGCAAGATAAAAATCCATACAGCTTTCAGTCAGATGTATATGCATTTGGAA TTGTTCTGTATGAATTGATGACTGGACAGTTACCTTATTCAAACATCAACAACAGGGACCAGATAATTTTTATGGTGGGACGAGGATACC TGTCTCCAGATCTCAGTAAGGTACGGAGTAACTGTCCAAAAGCCATGAAGAGATTAATGGCAGAGTGCCTCAAAAAGAAAAGAGATGAGA GACCACTCTTTCCCCAAATTCTCGCCTCTATTGAGCTGCTGGCCCGCTCATTGCCAAAAATTCACCGCAGTGCATCAGAACCCTCCTTGA ATCGGGCTGGTTTCCAAACAGAGGATTTTAGTCTATATGCTTGTGCTTCTCCAAAAACACCCATCCAGGCAGGGGGATATGGTGCGTTTC CTGTCCACTGAAACAAATGAGTGAGAGAGTTCAGGAGAGTAGCAACAAAAGGAAAATAAATGAACATATGTTTGCTTATATGTTAAATTG >54112_54112_11_MKRN1-BRAF_MKRN1_chr7_140158807_ENST00000474576_BRAF_chr7_140481493_ENST00000288602_length(amino acids)=521AA_BP=191 MHGVCKEGDNCRYSHDLSDSPYSVVCKYFQRGYCIYGDRCRYEHSKPLKQEEATATELTTKSSLAASSSLSSIVGPLVEMNTGEAESRNS NFATVGAGSEDWVNAIEFVPGQPYCGRTAPSCTEAPLQGSVTKEESEKEQTAVETKKQLCPYAAVGECRYGENCVYLHGDSCDMCGLQVL HPMDAAQRSQHIKKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILL FMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWS GSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAE -------------------------------------------------------------- >54112_54112_12_MKRN1-BRAF_MKRN1_chr7_140158807_ENST00000474576_BRAF_chr7_140487384_ENST00000288602_length(transcript)=2013nt_BP=734nt ACTGCGTCAACCCCCGCTGGGCCGCGGAGCCCTCAGCGCTGTCCGCGGAGGCCTGGCGGTGCGCGATTACTGCGGAGCCGCGGGGCTGCA CCGCCGCTTACACTTCCCTGAGCGCTGCCTGAGCTGGCTGCGAGCGCATCGGGGAGAGGTATTTTATGCATGGGGTTTGTAAGGAAGGAG ACAACTGTCGCTACTCGCATGACCTCTCTGACAGTCCGTATAGTGTAGTGTGCAAGTATTTTCAGCGAGGGTACTGTATTTATGGAGACC GCTGCAGATATGAACATAGCAAACCATTGAAACAGGAAGAAGCAACTGCTACAGAGCTAACTACAAAGTCATCCCTTGCTGCTTCCTCAA GTCTCTCATCGATAGTTGGACCACTTGTTGAAATGAATACAGGCGAAGCTGAGTCAAGAAATTCAAACTTTGCAACTGTAGGAGCAGGTT CAGAGGACTGGGTGAATGCTATTGAGTTTGTTCCTGGGCAACCCTACTGTGGCCGTACTGCGCCTTCCTGCACTGAAGCACCCCTGCAGG GCTCAGTGACCAAGGAAGAATCAGAGAAAGAGCAAACCGCCGTGGAGACAAAGAAGCAGCTGTGCCCCTATGCTGCAGTGGGAGAGTGCC GATACGGGGAGAACTGTGTGTATCTCCACGGAGATTCTTGTGACATGTGTGGGCTGCAGGTCCTGCATCCAATGGATGCTGCCCAGAGAT CGCAGCATATCAAAGACTTGATTAGAGACCAAGGATTTCGTGGTGATGGAGGATCAACCACAGGTTTGTCTGCTACCCCCCCTGCCTCAT TACCTGGCTCACTAACTAACGTGAAAGCCTTACAGAAATCTCCAGGACCTCAGCGAGAAAGGAAGTCATCTTCATCCTCAGAAGACAGGA ATCGAATGAAAACACTTGGTAGACGGGACTCGAGTGATGATTGGGAGATTCCTGATGGGCAGATTACAGTGGGACAAAGAATTGGATCTG GATCATTTGGAACAGTCTACAAGGGAAAGTGGCATGGTGATGTGGCAGTGAAAATGTTGAATGTGACAGCACCTACACCTCAGCAGTTAC AAGCCTTCAAAAATGAAGTAGGAGTACTCAGGAAAACACGACATGTGAATATCCTACTCTTCATGGGCTATTCCACAAAGCCACAACTGG CTATTGTTACCCAGTGGTGTGAGGGCTCCAGCTTGTATCACCATCTCCATATCATTGAGACCAAATTTGAGATGATCAAACTTATAGATA TTGCACGACAGACTGCACAGGGCATGGATTACTTACACGCCAAGTCAATCATCCACAGAGACCTCAAGAGTAATAATATATTTCTTCATG AAGACCTCACAGTAAAAATAGGTGATTTTGGTCTAGCTACAGTGAAATCTCGATGGAGTGGGTCCCATCAGTTTGAACAGTTGTCTGGAT CCATTTTGTGGATGGCACCAGAAGTCATCAGAATGCAAGATAAAAATCCATACAGCTTTCAGTCAGATGTATATGCATTTGGAATTGTTC TGTATGAATTGATGACTGGACAGTTACCTTATTCAAACATCAACAACAGGGACCAGATAATTTTTATGGTGGGACGAGGATACCTGTCTC CAGATCTCAGTAAGGTACGGAGTAACTGTCCAAAAGCCATGAAGAGATTAATGGCAGAGTGCCTCAAAAAGAAAAGAGATGAGAGACCAC TCTTTCCCCAAATTCTCGCCTCTATTGAGCTGCTGGCCCGCTCATTGCCAAAAATTCACCGCAGTGCATCAGAACCCTCCTTGAATCGGG CTGGTTTCCAAACAGAGGATTTTAGTCTATATGCTTGTGCTTCTCCAAAAACACCCATCCAGGCAGGGGGATATGGTGCGTTTCCTGTCC ACTGAAACAAATGAGTGAGAGAGTTCAGGAGAGTAGCAACAAAAGGAAAATAAATGAACATATGTTTGCTTATATGTTAAATTGAATAAA >54112_54112_12_MKRN1-BRAF_MKRN1_chr7_140158807_ENST00000474576_BRAF_chr7_140487384_ENST00000288602_length(amino acids)=579AA_BP=193 MHGVCKEGDNCRYSHDLSDSPYSVVCKYFQRGYCIYGDRCRYEHSKPLKQEEATATELTTKSSLAASSSLSSIVGPLVEMNTGEAESRNS NFATVGAGSEDWVNAIEFVPGQPYCGRTAPSCTEAPLQGSVTKEESEKEQTAVETKKQLCPYAAVGECRYGENCVYLHGDSCDMCGLQVL HPMDAAQRSQHIKDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQI TVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETK FEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQS DVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRS -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for MKRN1-BRAF |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for MKRN1-BRAF |
![]() (DrugBank Version 5.1.8 2021-05-08) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Tgene | BRAF | P15056 | DB08881 | Vemurafenib | Inhibitor | Small molecule | Approved |
Tgene | BRAF | P15056 | DB08881 | Vemurafenib | Inhibitor | Small molecule | Approved |
Tgene | BRAF | P15056 | DB08881 | Vemurafenib | Inhibitor | Small molecule | Approved |
Tgene | BRAF | P15056 | DB08896 | Regorafenib | Inhibitor | Small molecule | Approved |
Tgene | BRAF | P15056 | DB08896 | Regorafenib | Inhibitor | Small molecule | Approved |
Tgene | BRAF | P15056 | DB08896 | Regorafenib | Inhibitor | Small molecule | Approved |
Tgene | BRAF | P15056 | DB14840 | Ripretinib | Inhibitor | Small molecule | Approved |
Tgene | BRAF | P15056 | DB14840 | Ripretinib | Inhibitor | Small molecule | Approved |
Tgene | BRAF | P15056 | DB14840 | Ripretinib | Inhibitor | Small molecule | Approved |
Tgene | BRAF | P15056 | DB00398 | Sorafenib | Inhibitor | Small molecule | Approved|Investigational |
Tgene | BRAF | P15056 | DB00398 | Sorafenib | Inhibitor | Small molecule | Approved|Investigational |
Tgene | BRAF | P15056 | DB00398 | Sorafenib | Inhibitor | Small molecule | Approved|Investigational |
Tgene | BRAF | P15056 | DB08912 | Dabrafenib | Antagonist|Inhibitor | Small molecule | Approved|Investigational |
Tgene | BRAF | P15056 | DB08912 | Dabrafenib | Antagonist|Inhibitor | Small molecule | Approved|Investigational |
Tgene | BRAF | P15056 | DB08912 | Dabrafenib | Antagonist|Inhibitor | Small molecule | Approved|Investigational |
Tgene | BRAF | P15056 | DB11718 | Encorafenib | Inhibitor | Small molecule | Approved|Investigational |
Tgene | BRAF | P15056 | DB11718 | Encorafenib | Inhibitor | Small molecule | Approved|Investigational |
Tgene | BRAF | P15056 | DB11718 | Encorafenib | Inhibitor | Small molecule | Approved|Investigational |
Tgene | BRAF | P15056 | DB12010 | Fostamatinib | Inhibitor | Small molecule | Approved|Investigational |
Tgene | BRAF | P15056 | DB12010 | Fostamatinib | Inhibitor | Small molecule | Approved|Investigational |
Tgene | BRAF | P15056 | DB12010 | Fostamatinib | Inhibitor | Small molecule | Approved|Investigational |
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Related Diseases for MKRN1-BRAF |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | C0025202 | melanoma | 24 | CGI;CTD_human;UNIPROT | |
Tgene | C1275081 | Cardio-facio-cutaneous syndrome | 14 | CLINGEN;CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT | |
Tgene | C0009402 | Colorectal Carcinoma | 8 | CTD_human;UNIPROT | |
Tgene | C0028326 | Noonan Syndrome | 8 | CLINGEN;CTD_human;GENOMICS_ENGLAND;ORPHANET | |
Tgene | C0238463 | Papillary thyroid carcinoma | 8 | CTD_human;ORPHANET | |
Tgene | C0040136 | Thyroid Neoplasm | 6 | CGI;CTD_human | |
Tgene | C0151468 | Thyroid Gland Follicular Adenoma | 6 | CTD_human | |
Tgene | C0175704 | LEOPARD Syndrome | 6 | CLINGEN;GENOMICS_ENGLAND | |
Tgene | C0549473 | Thyroid carcinoma | 6 | CGI;CTD_human | |
Tgene | C3150970 | NOONAN SYNDROME 7 | 5 | CTD_human;GENOMICS_ENGLAND;UNIPROT | |
Tgene | C0009404 | Colorectal Neoplasms | 4 | CTD_human | |
Tgene | C3150971 | LEOPARD SYNDROME 3 | 4 | CTD_human;GENOMICS_ENGLAND;UNIPROT | |
Tgene | C1519086 | Pilomyxoid astrocytoma | 3 | ORPHANET | |
Tgene | C0004565 | Melanoma, B16 | 2 | CTD_human | |
Tgene | C0009075 | Melanoma, Cloudman S91 | 2 | CTD_human | |
Tgene | C0018598 | Melanoma, Harding-Passey | 2 | CTD_human | |
Tgene | C0023443 | Hairy Cell Leukemia | 2 | CGI;ORPHANET | |
Tgene | C0025205 | Melanoma, Experimental | 2 | CTD_human | |
Tgene | C0033578 | Prostatic Neoplasms | 2 | CTD_human | |
Tgene | C0152013 | Adenocarcinoma of lung (disorder) | 2 | CGI;CTD_human | |
Tgene | C0376358 | Malignant neoplasm of prostate | 2 | CTD_human | |
Tgene | C0587248 | Costello syndrome (disorder) | 2 | CLINGEN;CTD_human | |
Tgene | C3501843 | Nonmedullary Thyroid Carcinoma | 2 | CTD_human | |
Tgene | C3501844 | Familial Nonmedullary Thyroid Cancer | 2 | CTD_human | |
Tgene | C0002448 | Ameloblastoma | 1 | CTD_human | |
Tgene | C0004114 | Astrocytoma | 1 | CTD_human | |
Tgene | C0010276 | Craniopharyngioma | 1 | CTD_human;ORPHANET | |
Tgene | C0011860 | Diabetes Mellitus, Non-Insulin-Dependent | 1 | CTD_human | |
Tgene | C0017638 | Glioma | 1 | CGI;CTD_human | |
Tgene | C0019621 | Histiocytosis, Langerhans-Cell | 1 | CGI;ORPHANET | |
Tgene | C0022665 | Kidney Neoplasm | 1 | CTD_human | |
Tgene | C0023903 | Liver neoplasms | 1 | CTD_human | |
Tgene | C0024232 | Lymphatic Metastasis | 1 | CTD_human | |
Tgene | C0024694 | Mandibular Neoplasms | 1 | CTD_human | |
Tgene | C0027659 | Neoplasms, Experimental | 1 | CTD_human | |
Tgene | C0027962 | Melanocytic nevus | 1 | GENOMICS_ENGLAND | |
Tgene | C0036920 | Sezary Syndrome | 1 | CTD_human | |
Tgene | C0041409 | Turner Syndrome, Male | 1 | CTD_human | |
Tgene | C0079773 | Lymphoma, T-Cell, Cutaneous | 1 | CTD_human | |
Tgene | C0205768 | Subependymal Giant Cell Astrocytoma | 1 | CTD_human | |
Tgene | C0206686 | Adrenocortical carcinoma | 1 | CTD_human | |
Tgene | C0206754 | Neuroendocrine Tumors | 1 | CTD_human | |
Tgene | C0259783 | mixed gliomas | 1 | CTD_human | |
Tgene | C0278875 | Adult Craniopharyngioma | 1 | CTD_human | |
Tgene | C0280783 | Juvenile Pilocytic Astrocytoma | 1 | CTD_human | |
Tgene | C0280785 | Diffuse Astrocytoma | 1 | CTD_human | |
Tgene | C0334579 | Anaplastic astrocytoma | 1 | CGI;CTD_human | |
Tgene | C0334580 | Protoplasmic astrocytoma | 1 | CTD_human | |
Tgene | C0334581 | Gemistocytic astrocytoma | 1 | CTD_human | |
Tgene | C0334582 | Fibrillary Astrocytoma | 1 | CTD_human | |
Tgene | C0334583 | Pilocytic Astrocytoma | 1 | CGI;CTD_human | |
Tgene | C0338070 | Childhood Cerebral Astrocytoma | 1 | CTD_human | |
Tgene | C0345904 | Malignant neoplasm of liver | 1 | CTD_human | |
Tgene | C0376407 | Granulomatous Slack Skin | 1 | CTD_human | |
Tgene | C0406803 | Syringocystadenoma Papilliferum | 1 | GENOMICS_ENGLAND | |
Tgene | C0431128 | Papillary craniopharyngioma | 1 | CTD_human | |
Tgene | C0431129 | Adamantinous Craniopharyngioma | 1 | CTD_human | |
Tgene | C0547065 | Mixed oligoastrocytoma | 1 | CTD_human | |
Tgene | C0555198 | Malignant Glioma | 1 | CTD_human | |
Tgene | C0596263 | Carcinogenesis | 1 | CTD_human | |
Tgene | C0684249 | Carcinoma of lung | 1 | CGI;UNIPROT | |
Tgene | C0740457 | Malignant neoplasm of kidney | 1 | CTD_human | |
Tgene | C0750935 | Cerebral Astrocytoma | 1 | CTD_human | |
Tgene | C0750936 | Intracranial Astrocytoma | 1 | CTD_human | |
Tgene | C0751061 | Craniopharyngioma, Child | 1 | CTD_human | |
Tgene | C0920269 | Microsatellite Instability | 1 | CTD_human | |
Tgene | C1527404 | Female Pseudo-Turner Syndrome | 1 | CTD_human | |
Tgene | C1704230 | Grade I Astrocytoma | 1 | CTD_human | |
Tgene | C1721098 | Replication Error Phenotype | 1 | CTD_human | |
Tgene | C2239176 | Liver carcinoma | 1 | CTD_human | |
Tgene | C4551484 | Leopard Syndrome 1 | 1 | GENOMICS_ENGLAND | |
Tgene | C4551602 | Noonan Syndrome 1 | 1 | CTD_human | |
Tgene | C4721532 | Lymphoma, Non-Hodgkin, Familial | 1 | UNIPROT | |
Tgene | C4733333 | familial non-medullary thyroid cancer | 1 | GENOMICS_ENGLAND |