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in Kim Lab

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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:BRD1-TTLL8 (FusionGDB2 ID:HG23774TG164714)

Fusion Gene Summary for BRD1-TTLL8

check button Fusion gene summary
Fusion gene informationFusion gene name: BRD1-TTLL8
Fusion gene ID: hg23774tg164714
HgeneTgene
Gene symbol

BRD1

TTLL8

Gene ID

23774

164714

Gene namebromodomain containing 1tubulin tyrosine ligase like 8
SynonymsBRL|BRPF1|BRPF2-
Cytomap('BRD1')('TTLL8')

22q13.33

22q13.33

Type of geneprotein-codingprotein-coding
Descriptionbromodomain-containing protein 1BR140-like proteinbromodomain and PHD finger-containing protein 2protein monoglycylase TTLL8tubulin tyrosine ligase-like family, member 8tubulin--tyrosine ligase-like protein 8
Modification date2020032720200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000216267, ENST00000404034, 
ENST00000404760, ENST00000457780, 
ENST00000542442, ENST00000342989, 
ENST00000459821, 
Fusion gene scores* DoF score7 X 7 X 6=2941 X 1 X 1=1
# samples 81
** MAII scorelog2(8/294*10)=-1.877744249949
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(1/1*10)=3.32192809488736
Context

PubMed: BRD1 [Title/Abstract] AND TTLL8 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointBRD1(50216599)-TTLL8(50472891), # samples:1
Anticipated loss of major functional domain due to fusion event.BRD1-TTLL8 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
BRD1-TTLL8 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
BRD1-TTLL8 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
BRD1-TTLL8 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
BRD1-TTLL8 seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor due to the frame-shifted ORF.
BRD1-TTLL8 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
BRD1-TTLL8 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
BRD1-TTLL8 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneBRD1

GO:0043966

histone H3 acetylation

16387653


check buttonFusion gene breakpoints across BRD1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across TTLL8 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-AN-A0FJ-01ABRD1chr22

50216599

-TTLL8chr22

50472891

-


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Fusion Gene ORF analysis for BRD1-TTLL8

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000216267ENST00000477219BRD1chr22

50216599

-TTLL8chr22

50472891

-
5CDS-intronENST00000404034ENST00000477219BRD1chr22

50216599

-TTLL8chr22

50472891

-
5CDS-intronENST00000404760ENST00000477219BRD1chr22

50216599

-TTLL8chr22

50472891

-
5CDS-intronENST00000457780ENST00000477219BRD1chr22

50216599

-TTLL8chr22

50472891

-
5CDS-intronENST00000542442ENST00000477219BRD1chr22

50216599

-TTLL8chr22

50472891

-
5UTR-3CDSENST00000342989ENST00000266182BRD1chr22

50216599

-TTLL8chr22

50472891

-
5UTR-3CDSENST00000342989ENST00000440475BRD1chr22

50216599

-TTLL8chr22

50472891

-
5UTR-3CDSENST00000459821ENST00000266182BRD1chr22

50216599

-TTLL8chr22

50472891

-
5UTR-3CDSENST00000459821ENST00000440475BRD1chr22

50216599

-TTLL8chr22

50472891

-
5UTR-intronENST00000342989ENST00000477219BRD1chr22

50216599

-TTLL8chr22

50472891

-
5UTR-intronENST00000459821ENST00000477219BRD1chr22

50216599

-TTLL8chr22

50472891

-
Frame-shiftENST00000216267ENST00000440475BRD1chr22

50216599

-TTLL8chr22

50472891

-
Frame-shiftENST00000404034ENST00000266182BRD1chr22

50216599

-TTLL8chr22

50472891

-
Frame-shiftENST00000404760ENST00000266182BRD1chr22

50216599

-TTLL8chr22

50472891

-
Frame-shiftENST00000457780ENST00000440475BRD1chr22

50216599

-TTLL8chr22

50472891

-
Frame-shiftENST00000542442ENST00000440475BRD1chr22

50216599

-TTLL8chr22

50472891

-
In-frameENST00000216267ENST00000266182BRD1chr22

50216599

-TTLL8chr22

50472891

-
In-frameENST00000404034ENST00000440475BRD1chr22

50216599

-TTLL8chr22

50472891

-
In-frameENST00000404760ENST00000440475BRD1chr22

50216599

-TTLL8chr22

50472891

-
In-frameENST00000457780ENST00000266182BRD1chr22

50216599

-TTLL8chr22

50472891

-
In-frameENST00000542442ENST00000266182BRD1chr22

50216599

-TTLL8chr22

50472891

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000216267BRD1chr2250216599-ENST00000266182TTLL8chr2250472891-3438185418063437543
ENST00000404034BRD1chr2250216599-ENST00000440475TTLL8chr2250472891-312415521311864577
ENST00000404760BRD1chr2250216599-ENST00000440475TTLL8chr2250472891-29691397301709559
ENST00000457780BRD1chr2250216599-ENST00000266182TTLL8chr2250472891-2967138313352966543
ENST00000542442BRD1chr2250216599-ENST00000266182TTLL8chr2250472891-19353513031934543

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000216267ENST00000266182BRD1chr2250216599-TTLL8chr2250472891-0.1008338850.89916605
ENST00000404034ENST00000440475BRD1chr2250216599-TTLL8chr2250472891-0.0118436370.98815644
ENST00000404760ENST00000440475BRD1chr2250216599-TTLL8chr2250472891-0.0148658630.9851341
ENST00000457780ENST00000266182BRD1chr2250216599-TTLL8chr2250472891-0.145560790.8544392
ENST00000542442ENST00000266182BRD1chr2250216599-TTLL8chr2250472891-0.151281280.84871876

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Fusion Genomic Features for BRD1-TTLL8


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for BRD1-TTLL8


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr22:50216599/chr22:50472891)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneBRD1chr22:50216599chr22:50472891ENST00000216267-112214_2644551059.0Zinc fingerPHD-type 1
HgeneBRD1chr22:50216599chr22:50472891ENST00000216267-112268_3014551059.0Zinc fingerC2HC pre-PHD-type
HgeneBRD1chr22:50216599chr22:50472891ENST00000216267-112325_3894551059.0Zinc fingerPHD-type 2
HgeneBRD1chr22:50216599chr22:50472891ENST00000404034-213214_2644551059.0Zinc fingerPHD-type 1
HgeneBRD1chr22:50216599chr22:50472891ENST00000404034-213268_3014551059.0Zinc fingerC2HC pre-PHD-type
HgeneBRD1chr22:50216599chr22:50472891ENST00000404034-213325_3894551059.0Zinc fingerPHD-type 2
HgeneBRD1chr22:50216599chr22:50472891ENST00000404760-213214_2644551190.0Zinc fingerPHD-type 1
HgeneBRD1chr22:50216599chr22:50472891ENST00000404760-213268_3014551190.0Zinc fingerC2HC pre-PHD-type
HgeneBRD1chr22:50216599chr22:50472891ENST00000404760-213325_3894551190.0Zinc fingerPHD-type 2

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneBRD1chr22:50216599chr22:50472891ENST00000216267-112579_6494551059.0DomainBromo
HgeneBRD1chr22:50216599chr22:50472891ENST00000216267-112929_10124551059.0DomainPWWP
HgeneBRD1chr22:50216599chr22:50472891ENST00000404034-213579_6494551059.0DomainBromo
HgeneBRD1chr22:50216599chr22:50472891ENST00000404034-213929_10124551059.0DomainPWWP
HgeneBRD1chr22:50216599chr22:50472891ENST00000404760-213579_6494551190.0DomainBromo
HgeneBRD1chr22:50216599chr22:50472891ENST00000404760-213929_10124551190.0DomainPWWP


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Fusion Gene Sequence for BRD1-TTLL8


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>10172_10172_1_BRD1-TTLL8_BRD1_chr22_50216599_ENST00000216267_TTLL8_chr22_50472891_ENST00000266182_length(transcript)=3438nt_BP=1854nt
ATCCGATAGGACCAGGTAGCCACTGAGCATGCCTGTCTGGTGGGCATAGCCTCTGTGCCTGGTGGGGTCCAGCCCTGTATGTGGACTTCC
TGGGGGACCGCCTGCATGCTGGGAAAGTCCTGCAACTGTGGGCTCTGGGCCGGACCCCTCCTCCTTGGGGAGCGTTGCTGTGGTCTCCGC
AGCCTGTTGGTGTGGTCTGAGAGGGGACTGGTGTGTGGTGGTAGGGACGCAGGTGCTCAGGAGGGCTCCTCAGGCTGCCTCTCTGCCTGT
TACTGCTGCTCCCTCCCTGGTCCTGGGGACTCGCTCAGGCCTGGATGTGTGGTTTTGGACACCTTGGAAAGAGGTTAGCTGTGAGTTTTG
CTTTGATTGGGCTTTGAGCTGCTGAGCTAGATCTGTCCAAGCATGCTTTTGTGGTTTTCTCGAGTCTTTGGTCACCCTGCGTAGAATTAC
CTTTACTTTTGCCTTCATTTTAGGTAATCATTACCAAATGAGGAGGAAAGGACGATGTCATCGAGGCTCTGCAGCGAGGCATCCTTCTTC
CCCATGCAGTGTTAAACACTCCCCTACGCGAGAAACGCTGACCTACGCTCAAGCTCAAAGGATGGTAGAGATAGAAATTGAAGGGCGCTT
GCACAGGATCAGTATTTTTGATCCCCTGGAGATCATATTGGAAGATGACCTCACTGCTCAAGAGATGAGTGAGTGCAACAGCAACAAGGA
AAACAGCGAGCGGCCTCCTGTCTGCTTAAGAACTAAGCGTCACAAAAACAACAGAGTCAAAAAGAAAAACGAGGCCCTCCCCAGCGCCCA
CGGCACGCCGGCCTCGGCCAGTGCCCTCCCGGAGCCCAAGGTGCGCATCGTGGAGTACAGCCCTCCGTCCGCCCCCAGGAGGCCTCCTGT
GTACTACAAGTTCATCGAGAAGTCGGCCGAGGAACTGGACAACGAGGTGGAGTATGACATGGACGAGGAGGACTATGCCTGGCTGGAGAT
CGTCAATGAGAAGCGCAAGGGCGACTGCGTCCCCGCCGTGTCGCAGAGCATGTTTGAGTTCCTGATGGACCGCTTCGAGAAGGAGTCGCA
CTGCGAGAACCAGAAGCAGGGCGAGCAGCAGTCTCTGATCGACGAGGACGCCGTGTGCTGCATCTGCATGGACGGGGAGTGTCAGAACAG
CAACGTGATCCTCTTCTGCGACATGTGCAACCTGGCCGTGCACCAGGAGTGCTACGGGGTGCCCTACATCCCCGAGGGCCAGTGGCTCTG
CCGCCACTGCCTGCAGTCGCGGGCCCGGCCCGCCGACTGTGTGCTGTGCCCCAACAAGGGTGGTGCCTTCAAAAAGACAGATGACGACCG
CTGGGGTCACGTGGTGTGTGCCCTGTGGATCCCAGAGGTCGGCTTTGCCAACACGGTGTTCATCGAGCCCATCGATGGGGTGAGGAACAT
CCCTCCAGCCCGGTGGAAACTGACATGCTACCTCTGTAAGCAGAAGGGCGTGGGTGCCTGCATCCAGTGCCACAAAGCAAACTGCTACAC
AGCATTCCATGTGACGTGTGCCCAGAAGGCTGGCCTGTACATGAAAATGGAGCCCGTGAAGGAACTGACTGGCGGTGGCACCACCTTCTC
CGTCAGAAAGACCGCTTACTGTGATGTCCACACGCCTCCAGGCTGCACCCGGAGGCCTCTGAATATTTACGGGGATGTCGAAATGAAAAA
TGGCGTCTGTCGAAAAGAGAGCTCGGTTAAAACGGTCAGGTCCACATCCAAGGTCAGGAAGAAGGCAAAAAAGGCTAAGAAAGCTCTGGC
TGAGCCCTGCGCGGTCCTGCCGACCGTGTGCGCTCCTTATATTCCCCCGCAGAGTGCCAGGCTCTGCTGAATAGAATCACGTCTGTGAAC
CCTCAGACGGACATTGACGGGCTCCGGAACATCTGGATTATAAAGCCCGCGGCCAAGTCCCGGGGCCGAGGTGAGTCCCCTGACATAGTG
TGCATGGACCGTGTGGAGGAGATCCTGGAGCTGGCAGCTGCAGACCACCCTCTTTCCAGGGACAACAAGTGGGTGGTCCAGAAGTACATC
GAGACGCCGCTGCTCATCTGTGACACCAAGTTCGACATCAGACAGTGGTTCCTCGTCACGGACTGGAACCCCCTGACCATCTGGTTCTAC
AAGGAGAGTTACTTGCGGTTCTCAACTCAGCGCTTCTCCCTGGACAAGCTGGACAGCGCCATCCACCTGTGCAACAACGCCGTCCAGAAG
TACCTGAAGAATGATGTGGGCCGCAGCCCCCTGCTGCCCGCACACAACATGTGGACCAGCACCAGGTTCCAGGAGTACCTGCAGCGCCAG
GGCCGTGGCGCCGTGTGGGGCAGCGTCATCTACCCGTCCATGAAGAAGGCCATCGCCCACGCCATGAAGGTGGCCCAGGACCACGTGGAG
CCTCGCAAGAACAGCTTTGAGCTCTACGGGGCTGACTTCGTCCTTGGGAGGGACTTCAGGCCCTGGCTGATCGAGATCAATTCCAGCCCC
ACCATGCACCCGTCCACGCCGGTCACGGCCCAGCTGTGTGCACAGGTGCAGGAGGACACCATCAAGGTGGCCGTGGACCGCAGCTGTGAC
ATCGGCAACTTCGAGCTCCTGTGGAGGCAGCCGGTGGTTGAGCCGCCCCCATTCAGCGGGTCCGACCTCTGCGTGGCGGGCGTCAGTGTG
AGGAGAGCCAGGAGGCAGGTGCTGCCCGTCTGCAACCTCAAGGCCTCGGCCTCGCTGTTGGACGCGCAGCCGCTGAAGGCACGGGGCCCC
TCGGCCATGCCAGACCCTGCCCAGGGACCCCCATCACCAGCTCTCCAGCGGGACTTGGGACTGAAGGAAGAGAAGGGGCTCCCCCTGGCC
TTGCTGGCACCCTTAAGGGGGGCAGCCGAGAGCGGTGGAGCCGCACAGCCCACCCGCACCAAAGCTGCTGGGAAGGTGGAGCTCCCGGCC
TGCCCCTGTCGCCACGTGGACAGTCAGGCCCCAAACACCGGTGTCCCCGTAGCCCAGCCCGCCAAAAGCTGGGATCCAAACCAGCTAAAT
GCGCACCCGCTGGAGCCTGTGCTGCGGGGCCTGAAGACAGCAGAGGGCGCGCTGCGTCCGCCGCCCGGAGGAAAAGGAGAGGGCACGGTC
TGCAGCCGCCTGCCACACCACGGGCACCACGTGGCCGCCTGCCAGACCACGGGCACCACGTGGGATGGTGGGCCTGGGGTGTGCTTCCTC
CGGCAGCTCCTGGCATCAGAACTGCCCATGGGCCCTGGGCTGCCGAGGGACCCCCGAGCGCCGCCCTGCCTCGTGTGCCGCGGGCTGCTG
CCACCCGCCGGGCCCTGCAAGCGCTGCCGCTCGTTCTGCGCCGCGGTCCTGCAGGGCGCGTCCTTCGTGCGGCTCGGCGGGCGGAGCTGC
AGCCCGCGGACCCCGTGA

>10172_10172_1_BRD1-TTLL8_BRD1_chr22_50216599_ENST00000216267_TTLL8_chr22_50472891_ENST00000266182_length(amino acids)=543AA_BP=16
MRGPADRVRSLYSPAECQALLNRITSVNPQTDIDGLRNIWIIKPAAKSRGRGESPDIVCMDRVEEILELAAADHPLSRDNKWVVQKYIET
PLLICDTKFDIRQWFLVTDWNPLTIWFYKESYLRFSTQRFSLDKLDSAIHLCNNAVQKYLKNDVGRSPLLPAHNMWTSTRFQEYLQRQGR
GAVWGSVIYPSMKKAIAHAMKVAQDHVEPRKNSFELYGADFVLGRDFRPWLIEINSSPTMHPSTPVTAQLCAQVQEDTIKVAVDRSCDIG
NFELLWRQPVVEPPPFSGSDLCVAGVSVRRARRQVLPVCNLKASASLLDAQPLKARGPSAMPDPAQGPPSPALQRDLGLKEEKGLPLALL
APLRGAAESGGAAQPTRTKAAGKVELPACPCRHVDSQAPNTGVPVAQPAKSWDPNQLNAHPLEPVLRGLKTAEGALRPPPGGKGEGTVCS
RLPHHGHHVAACQTTGTTWDGGPGVCFLRQLLASELPMGPGLPRDPRAPPCLVCRGLLPPAGPCKRCRSFCAAVLQGASFVRLGGRSCSP
RTP

--------------------------------------------------------------
>10172_10172_2_BRD1-TTLL8_BRD1_chr22_50216599_ENST00000404034_TTLL8_chr22_50472891_ENST00000440475_length(transcript)=3124nt_BP=1552nt
CAATCTAGTTTCAACATACAATGAGGATTTCTGTCTGATACAGAGAAAGATACCCAGTGTCTGGAGGGTCTGTCTTAAGAAGTGCTCTTG
AAGTCTGCTGGGATTTCCTTTCGGGACTCACAGAGGGAAGCCTGCTCCCTGAGGGCTTTTTCTCAGGCCCAATAGATCAGGGTAATCATT
ACCAAATGAGGAGGAAAGGACGATGTCATCGAGGCTCTGCAGCGAGGCATCCTTCTTCCCCATGCAGTGTTAAACACTCCCCTACGCGAG
AAACGCTGACCTACGCTCAAGCTCAAAGGATGGTAGAGATAGAAATTGAAGGGCGCTTGCACAGGATCAGTATTTTTGATCCCCTGGAGA
TCATATTGGAAGATGACCTCACTGCTCAAGAGATGAGTGAGTGCAACAGCAACAAGGAAAACAGCGAGCGGCCTCCTGTCTGCTTAAGAA
CTAAGCGTCACAAAAACAACAGAGTCAAAAAGAAAAACGAGGCCCTCCCCAGCGCCCACGGCACGCCGGCCTCGGCCAGTGCCCTCCCGG
AGCCCAAGGTGCGCATCGTGGAGTACAGCCCTCCGTCCGCCCCCAGGAGGCCTCCTGTGTACTACAAGTTCATCGAGAAGTCGGCCGAGG
AACTGGACAACGAGGTGGAGTATGACATGGACGAGGAGGACTATGCCTGGCTGGAGATCGTCAATGAGAAGCGCAAGGGCGACTGCGTCC
CCGCCGTGTCGCAGAGCATGTTTGAGTTCCTGATGGACCGCTTCGAGAAGGAGTCGCACTGCGAGAACCAGAAGCAGGGCGAGCAGCAGT
CTCTGATCGACGAGGACGCCGTGTGCTGCATCTGCATGGACGGGGAGTGTCAGAACAGCAACGTGATCCTCTTCTGCGACATGTGCAACC
TGGCCGTGCACCAGGAGTGCTACGGGGTGCCCTACATCCCCGAGGGCCAGTGGCTCTGCCGCCACTGCCTGCAGTCGCGGGCCCGGCCCG
CCGACTGTGTGCTGTGCCCCAACAAGGGTGGTGCCTTCAAAAAGACAGATGACGACCGCTGGGGTCACGTGGTGTGTGCCCTGTGGATCC
CAGAGGTCGGCTTTGCCAACACGGTGTTCATCGAGCCCATCGATGGGGTGAGGAACATCCCTCCAGCCCGGTGGAAACTGACATGCTACC
TCTGTAAGCAGAAGGGCGTGGGTGCCTGCATCCAGTGCCACAAAGCAAACTGCTACACAGCATTCCATGTGACGTGTGCCCAGAAGGCTG
GCCTGTACATGAAAATGGAGCCCGTGAAGGAACTGACTGGCGGTGGCACCACCTTCTCCGTCAGAAAGACCGCTTACTGTGATGTCCACA
CGCCTCCAGGCTGCACCCGGAGGCCTCTGAATATTTACGGGGATGTCGAAATGAAAAATGGCGTCTGTCGAAAAGAGAGCTCGGTTAAAA
CGGTCAGGTCCACATCCAAGGTCAGGAAGAAGGCAAAAAAGGCTAAGAAAGCTCTGGCTGAGCCCTGCGCGGTCCTGCCGACCGTGTGCG
CTCCTTATATTCCCCCGCAGAGGGCTGCCGAGGGACCCCCGAGCGCCGCCCTGCCTCGTGTGCCGCGGGCTGCTGCCACCCGCCGGGCCC
TGCAAGCGCTGCCGCTCGTTCTGCGCCGCGGTCCTGCAGGGCGCGTCCTTCGTGCGGCTCGGCGGGCGGAGCTGCAGCCCGCGGACCCCG
TGAGAGAGGGCACGGTCTGCAGCCGCCTGCCACACCACGGGCACCACGTGGCCGCCTGCCAGACCACGGGCACCACGTGGGATGGTGGGC
CTGGGGTGTGCTTCCTCCGGCAGCTCCTGGCATCAGAACTGCCCATGGGCCCTGCCGGTGGTTGAGCCGCCCCCATTCAGCGGGTCCGAC
CTCTGCGTGGCGGGCGTCAGTGTGAGGAGAGCCAGGAGGCAGGTGCTGCCCGTCTGCAACCTCAAGGCCTCGGCCTCGCTGTTGGACGCG
CAGCCGCTGAAGGCACGGGGCCCCTCGGCCATGCCAGACCCTGCCCAGGGACCCCCATCACCAGCTCTCCAGCGGGACTTGGGACTGAAG
GAAGAGAAGGGGCTCCCCCTGGCCTTGCTGGCACCCTTAAGGGGGGCAGCCGAGAGCGGTGGAGCCGCACAGCCCACCCGCACCAAAGCT
GCTGGGAAGGTGGAGCTCCCGGCCTGCCCCTGTCGCCACGTGGACAGTCAGGCCCCAAACACCGGTGTCCCCGTAGCCCAGCCCGCCAAA
AGCTGGGATCCAAACCAGCTAAATGCGCACCCGCTGGAGCCTGTGCTGCGGGGCCTGAAGACAGCAGAGGGCGCGCTGCGTCCGCCGCCC
GGAGGAAAAGCGCCATCCACCTGTGCAACAACGCCGTCCAGAAGTACCTGAAGAATGATGTGGGCCGCAGCCCCCTGCTGCCCGCACACA
ACATGTGGACCAGCACCAGGTTCCAGGAGTACCTGCAGCGCCAGGGCCGTGGCGCCGTGTGGGGCAGCGTCATCTACCCGTCCATGAAGA
AGGCCATCGCCCACGCCATGAAGGTGGCCCAGGACCACGTGGAGCCTCGCAAGAACAGCTTTGAGCTCTACGGGGCTGACTTCGTCCTTG
GGAGGGACTTCAGGCCCTGGCTGATCGAGATCAATTCCAGCCCCACCATGCACCCGTCCACGCCGGTCACGGCCCAGCTGTGTGCACAGG
TGCAGGAGGACACCATCAAGGTGGCCGTGGACCGCAGCTGTGACATCGGCAACTTCGAGCTCCTGTGGAGGCAGACATAGTGTGCATGGA
CCGTGTGGAGGAGATCCTGGAGCTGGCAGCTGCAGACCACCCTCTTTCCAGGGACAACAAGTGGGTGGTCCAGAAGTACATCGAGACGCC
GCTGCTCATCTGTGACACCAAGTTCGACATCAGACAGTGGTTCCTCGTCACGGACTGGAACCCCCTGACCATCTGGTTCTACAAGGAGAG
TTACTTGCGGTTCTCAACTCAGCGCTTCTCCCTGGACAAGCTGGACAGTGCCAGGCTCTGCTGAATAGAATCACGTCTGTGAACCCTCAG
ACGGACATTGACGGGCTCCGGAACATCTGGATTATAAAGCCCGCGGCCAAGTCCCGGGGCCGAG

>10172_10172_2_BRD1-TTLL8_BRD1_chr22_50216599_ENST00000404034_TTLL8_chr22_50472891_ENST00000440475_length(amino acids)=577AA_BP=
MLPEGFFSGPIDQGNHYQMRRKGRCHRGSAARHPSSPCSVKHSPTRETLTYAQAQRMVEIEIEGRLHRISIFDPLEIILEDDLTAQEMSE
CNSNKENSERPPVCLRTKRHKNNRVKKKNEALPSAHGTPASASALPEPKVRIVEYSPPSAPRRPPVYYKFIEKSAEELDNEVEYDMDEED
YAWLEIVNEKRKGDCVPAVSQSMFEFLMDRFEKESHCENQKQGEQQSLIDEDAVCCICMDGECQNSNVILFCDMCNLAVHQECYGVPYIP
EGQWLCRHCLQSRARPADCVLCPNKGGAFKKTDDDRWGHVVCALWIPEVGFANTVFIEPIDGVRNIPPARWKLTCYLCKQKGVGACIQCH
KANCYTAFHVTCAQKAGLYMKMEPVKELTGGGTTFSVRKTAYCDVHTPPGCTRRPLNIYGDVEMKNGVCRKESSVKTVRSTSKVRKKAKK
AKKALAEPCAVLPTVCAPYIPPQRAAEGPPSAALPRVPRAAATRRALQALPLVLRRGPAGRVLRAARRAELQPADPVREGTVCSRLPHHG
HHVAACQTTGTTWDGGPGVCFLRQLLASELPMGPAGG

--------------------------------------------------------------
>10172_10172_3_BRD1-TTLL8_BRD1_chr22_50216599_ENST00000404760_TTLL8_chr22_50472891_ENST00000440475_length(transcript)=2969nt_BP=1397nt
CCGCGGCGCCCCGAAGGTAATCATTACCAAATGAGGAGGAAAGGACGATGTCATCGAGGCTCTGCAGCGAGGCATCCTTCTTCCCCATGC
AGTGTTAAACACTCCCCTACGCGAGAAACGCTGACCTACGCTCAAGCTCAAAGGATGGTAGAGATAGAAATTGAAGGGCGCTTGCACAGG
ATCAGTATTTTTGATCCCCTGGAGATCATATTGGAAGATGACCTCACTGCTCAAGAGATGAGTGAGTGCAACAGCAACAAGGAAAACAGC
GAGCGGCCTCCTGTCTGCTTAAGAACTAAGCGTCACAAAAACAACAGAGTCAAAAAGAAAAACGAGGCCCTCCCCAGCGCCCACGGCACG
CCGGCCTCGGCCAGTGCCCTCCCGGAGCCCAAGGTGCGCATCGTGGAGTACAGCCCTCCGTCCGCCCCCAGGAGGCCTCCTGTGTACTAC
AAGTTCATCGAGAAGTCGGCCGAGGAACTGGACAACGAGGTGGAGTATGACATGGACGAGGAGGACTATGCCTGGCTGGAGATCGTCAAT
GAGAAGCGCAAGGGCGACTGCGTCCCCGCCGTGTCGCAGAGCATGTTTGAGTTCCTGATGGACCGCTTCGAGAAGGAGTCGCACTGCGAG
AACCAGAAGCAGGGCGAGCAGCAGTCTCTGATCGACGAGGACGCCGTGTGCTGCATCTGCATGGACGGGGAGTGTCAGAACAGCAACGTG
ATCCTCTTCTGCGACATGTGCAACCTGGCCGTGCACCAGGAGTGCTACGGGGTGCCCTACATCCCCGAGGGCCAGTGGCTCTGCCGCCAC
TGCCTGCAGTCGCGGGCCCGGCCCGCCGACTGTGTGCTGTGCCCCAACAAGGGTGGTGCCTTCAAAAAGACAGATGACGACCGCTGGGGT
CACGTGGTGTGTGCCCTGTGGATCCCAGAGGTCGGCTTTGCCAACACGGTGTTCATCGAGCCCATCGATGGGGTGAGGAACATCCCTCCA
GCCCGGTGGAAACTGACATGCTACCTCTGTAAGCAGAAGGGCGTGGGTGCCTGCATCCAGTGCCACAAAGCAAACTGCTACACAGCATTC
CATGTGACGTGTGCCCAGAAGGCTGGCCTGTACATGAAAATGGAGCCCGTGAAGGAACTGACTGGCGGTGGCACCACCTTCTCCGTCAGA
AAGACCGCTTACTGTGATGTCCACACGCCTCCAGGCTGCACCCGGAGGCCTCTGAATATTTACGGGGATGTCGAAATGAAAAATGGCGTC
TGTCGAAAAGAGAGCTCGGTTAAAACGGTCAGGTCCACATCCAAGGTCAGGAAGAAGGCAAAAAAGGCTAAGAAAGCTCTGGCTGAGCCC
TGCGCGGTCCTGCCGACCGTGTGCGCTCCTTATATTCCCCCGCAGAGGGCTGCCGAGGGACCCCCGAGCGCCGCCCTGCCTCGTGTGCCG
CGGGCTGCTGCCACCCGCCGGGCCCTGCAAGCGCTGCCGCTCGTTCTGCGCCGCGGTCCTGCAGGGCGCGTCCTTCGTGCGGCTCGGCGG
GCGGAGCTGCAGCCCGCGGACCCCGTGAGAGAGGGCACGGTCTGCAGCCGCCTGCCACACCACGGGCACCACGTGGCCGCCTGCCAGACC
ACGGGCACCACGTGGGATGGTGGGCCTGGGGTGTGCTTCCTCCGGCAGCTCCTGGCATCAGAACTGCCCATGGGCCCTGCCGGTGGTTGA
GCCGCCCCCATTCAGCGGGTCCGACCTCTGCGTGGCGGGCGTCAGTGTGAGGAGAGCCAGGAGGCAGGTGCTGCCCGTCTGCAACCTCAA
GGCCTCGGCCTCGCTGTTGGACGCGCAGCCGCTGAAGGCACGGGGCCCCTCGGCCATGCCAGACCCTGCCCAGGGACCCCCATCACCAGC
TCTCCAGCGGGACTTGGGACTGAAGGAAGAGAAGGGGCTCCCCCTGGCCTTGCTGGCACCCTTAAGGGGGGCAGCCGAGAGCGGTGGAGC
CGCACAGCCCACCCGCACCAAAGCTGCTGGGAAGGTGGAGCTCCCGGCCTGCCCCTGTCGCCACGTGGACAGTCAGGCCCCAAACACCGG
TGTCCCCGTAGCCCAGCCCGCCAAAAGCTGGGATCCAAACCAGCTAAATGCGCACCCGCTGGAGCCTGTGCTGCGGGGCCTGAAGACAGC
AGAGGGCGCGCTGCGTCCGCCGCCCGGAGGAAAAGCGCCATCCACCTGTGCAACAACGCCGTCCAGAAGTACCTGAAGAATGATGTGGGC
CGCAGCCCCCTGCTGCCCGCACACAACATGTGGACCAGCACCAGGTTCCAGGAGTACCTGCAGCGCCAGGGCCGTGGCGCCGTGTGGGGC
AGCGTCATCTACCCGTCCATGAAGAAGGCCATCGCCCACGCCATGAAGGTGGCCCAGGACCACGTGGAGCCTCGCAAGAACAGCTTTGAG
CTCTACGGGGCTGACTTCGTCCTTGGGAGGGACTTCAGGCCCTGGCTGATCGAGATCAATTCCAGCCCCACCATGCACCCGTCCACGCCG
GTCACGGCCCAGCTGTGTGCACAGGTGCAGGAGGACACCATCAAGGTGGCCGTGGACCGCAGCTGTGACATCGGCAACTTCGAGCTCCTG
TGGAGGCAGACATAGTGTGCATGGACCGTGTGGAGGAGATCCTGGAGCTGGCAGCTGCAGACCACCCTCTTTCCAGGGACAACAAGTGGG
TGGTCCAGAAGTACATCGAGACGCCGCTGCTCATCTGTGACACCAAGTTCGACATCAGACAGTGGTTCCTCGTCACGGACTGGAACCCCC
TGACCATCTGGTTCTACAAGGAGAGTTACTTGCGGTTCTCAACTCAGCGCTTCTCCCTGGACAAGCTGGACAGTGCCAGGCTCTGCTGAA
TAGAATCACGTCTGTGAACCCTCAGACGGACATTGACGGGCTCCGGAACATCTGGATTATAAAGCCCGCGGCCAAGTCCCGGGGCCGAG

>10172_10172_3_BRD1-TTLL8_BRD1_chr22_50216599_ENST00000404760_TTLL8_chr22_50472891_ENST00000440475_length(amino acids)=559AA_BP=
MRRKGRCHRGSAARHPSSPCSVKHSPTRETLTYAQAQRMVEIEIEGRLHRISIFDPLEIILEDDLTAQEMSECNSNKENSERPPVCLRTK
RHKNNRVKKKNEALPSAHGTPASASALPEPKVRIVEYSPPSAPRRPPVYYKFIEKSAEELDNEVEYDMDEEDYAWLEIVNEKRKGDCVPA
VSQSMFEFLMDRFEKESHCENQKQGEQQSLIDEDAVCCICMDGECQNSNVILFCDMCNLAVHQECYGVPYIPEGQWLCRHCLQSRARPAD
CVLCPNKGGAFKKTDDDRWGHVVCALWIPEVGFANTVFIEPIDGVRNIPPARWKLTCYLCKQKGVGACIQCHKANCYTAFHVTCAQKAGL
YMKMEPVKELTGGGTTFSVRKTAYCDVHTPPGCTRRPLNIYGDVEMKNGVCRKESSVKTVRSTSKVRKKAKKAKKALAEPCAVLPTVCAP
YIPPQRAAEGPPSAALPRVPRAAATRRALQALPLVLRRGPAGRVLRAARRAELQPADPVREGTVCSRLPHHGHHVAACQTTGTTWDGGPG
VCFLRQLLASELPMGPAGG

--------------------------------------------------------------
>10172_10172_4_BRD1-TTLL8_BRD1_chr22_50216599_ENST00000457780_TTLL8_chr22_50472891_ENST00000266182_length(transcript)=2967nt_BP=1383nt
AGGTAATCATTACCAAATGAGGAGGAAAGGACGATGTCATCGAGGCTCTGCAGCGAGGCATCCTTCTTCCCCATGCAGTGTTAAACACTC
CCCTACGCGAGAAACGCTGACCTACGCTCAAGCTCAAAGGATGGTAGAGATAGAAATTGAAGGGCGCTTGCACAGGATCAGTATTTTTGA
TCCCCTGGAGATCATATTGGAAGATGACCTCACTGCTCAAGAGATGAGTGAGTGCAACAGCAACAAGGAAAACAGCGAGCGGCCTCCTGT
CTGCTTAAGAACTAAGCGTCACAAAAACAACAGAGTCAAAAAGAAAAACGAGGCCCTCCCCAGCGCCCACGGCACGCCGGCCTCGGCCAG
TGCCCTCCCGGAGCCCAAGGTGCGCATCGTGGAGTACAGCCCTCCGTCCGCCCCCAGGAGGCCTCCTGTGTACTACAAGTTCATCGAGAA
GTCGGCCGAGGAACTGGACAACGAGGTGGAGTATGACATGGACGAGGAGGACTATGCCTGGCTGGAGATCGTCAATGAGAAGCGCAAGGG
CGACTGCGTCCCCGCCGTGTCGCAGAGCATGTTTGAGTTCCTGATGGACCGCTTCGAGAAGGAGTCGCACTGCGAGAACCAGAAGCAGGG
CGAGCAGCAGTCTCTGATCGACGAGGACGCCGTGTGCTGCATCTGCATGGACGGGGAGTGTCAGAACAGCAACGTGATCCTCTTCTGCGA
CATGTGCAACCTGGCCGTGCACCAGGAGTGCTACGGGGTGCCCTACATCCCCGAGGGCCAGTGGCTCTGCCGCCACTGCCTGCAGTCGCG
GGCCCGGCCCGCCGACTGTGTGCTGTGCCCCAACAAGGGTGGTGCCTTCAAAAAGACAGATGACGACCGCTGGGGTCACGTGGTGTGTGC
CCTGTGGATCCCAGAGGTCGGCTTTGCCAACACGGTGTTCATCGAGCCCATCGATGGGGTGAGGAACATCCCTCCAGCCCGGTGGAAACT
GACATGCTACCTCTGTAAGCAGAAGGGCGTGGGTGCCTGCATCCAGTGCCACAAAGCAAACTGCTACACAGCATTCCATGTGACGTGTGC
CCAGAAGGCTGGCCTGTACATGAAAATGGAGCCCGTGAAGGAACTGACTGGCGGTGGCACCACCTTCTCCGTCAGAAAGACCGCTTACTG
TGATGTCCACACGCCTCCAGGCTGCACCCGGAGGCCTCTGAATATTTACGGGGATGTCGAAATGAAAAATGGCGTCTGTCGAAAAGAGAG
CTCGGTTAAAACGGTCAGGTCCACATCCAAGGTCAGGAAGAAGGCAAAAAAGGCTAAGAAAGCTCTGGCTGAGCCCTGCGCGGTCCTGCC
GACCGTGTGCGCTCCTTATATTCCCCCGCAGAGTGCCAGGCTCTGCTGAATAGAATCACGTCTGTGAACCCTCAGACGGACATTGACGGG
CTCCGGAACATCTGGATTATAAAGCCCGCGGCCAAGTCCCGGGGCCGAGGTGAGTCCCCTGACATAGTGTGCATGGACCGTGTGGAGGAG
ATCCTGGAGCTGGCAGCTGCAGACCACCCTCTTTCCAGGGACAACAAGTGGGTGGTCCAGAAGTACATCGAGACGCCGCTGCTCATCTGT
GACACCAAGTTCGACATCAGACAGTGGTTCCTCGTCACGGACTGGAACCCCCTGACCATCTGGTTCTACAAGGAGAGTTACTTGCGGTTC
TCAACTCAGCGCTTCTCCCTGGACAAGCTGGACAGCGCCATCCACCTGTGCAACAACGCCGTCCAGAAGTACCTGAAGAATGATGTGGGC
CGCAGCCCCCTGCTGCCCGCACACAACATGTGGACCAGCACCAGGTTCCAGGAGTACCTGCAGCGCCAGGGCCGTGGCGCCGTGTGGGGC
AGCGTCATCTACCCGTCCATGAAGAAGGCCATCGCCCACGCCATGAAGGTGGCCCAGGACCACGTGGAGCCTCGCAAGAACAGCTTTGAG
CTCTACGGGGCTGACTTCGTCCTTGGGAGGGACTTCAGGCCCTGGCTGATCGAGATCAATTCCAGCCCCACCATGCACCCGTCCACGCCG
GTCACGGCCCAGCTGTGTGCACAGGTGCAGGAGGACACCATCAAGGTGGCCGTGGACCGCAGCTGTGACATCGGCAACTTCGAGCTCCTG
TGGAGGCAGCCGGTGGTTGAGCCGCCCCCATTCAGCGGGTCCGACCTCTGCGTGGCGGGCGTCAGTGTGAGGAGAGCCAGGAGGCAGGTG
CTGCCCGTCTGCAACCTCAAGGCCTCGGCCTCGCTGTTGGACGCGCAGCCGCTGAAGGCACGGGGCCCCTCGGCCATGCCAGACCCTGCC
CAGGGACCCCCATCACCAGCTCTCCAGCGGGACTTGGGACTGAAGGAAGAGAAGGGGCTCCCCCTGGCCTTGCTGGCACCCTTAAGGGGG
GCAGCCGAGAGCGGTGGAGCCGCACAGCCCACCCGCACCAAAGCTGCTGGGAAGGTGGAGCTCCCGGCCTGCCCCTGTCGCCACGTGGAC
AGTCAGGCCCCAAACACCGGTGTCCCCGTAGCCCAGCCCGCCAAAAGCTGGGATCCAAACCAGCTAAATGCGCACCCGCTGGAGCCTGTG
CTGCGGGGCCTGAAGACAGCAGAGGGCGCGCTGCGTCCGCCGCCCGGAGGAAAAGGAGAGGGCACGGTCTGCAGCCGCCTGCCACACCAC
GGGCACCACGTGGCCGCCTGCCAGACCACGGGCACCACGTGGGATGGTGGGCCTGGGGTGTGCTTCCTCCGGCAGCTCCTGGCATCAGAA
CTGCCCATGGGCCCTGGGCTGCCGAGGGACCCCCGAGCGCCGCCCTGCCTCGTGTGCCGCGGGCTGCTGCCACCCGCCGGGCCCTGCAAG
CGCTGCCGCTCGTTCTGCGCCGCGGTCCTGCAGGGCGCGTCCTTCGTGCGGCTCGGCGGGCGGAGCTGCAGCCCGCGGACCCCGTGA

>10172_10172_4_BRD1-TTLL8_BRD1_chr22_50216599_ENST00000457780_TTLL8_chr22_50472891_ENST00000266182_length(amino acids)=543AA_BP=16
MRGPADRVRSLYSPAECQALLNRITSVNPQTDIDGLRNIWIIKPAAKSRGRGESPDIVCMDRVEEILELAAADHPLSRDNKWVVQKYIET
PLLICDTKFDIRQWFLVTDWNPLTIWFYKESYLRFSTQRFSLDKLDSAIHLCNNAVQKYLKNDVGRSPLLPAHNMWTSTRFQEYLQRQGR
GAVWGSVIYPSMKKAIAHAMKVAQDHVEPRKNSFELYGADFVLGRDFRPWLIEINSSPTMHPSTPVTAQLCAQVQEDTIKVAVDRSCDIG
NFELLWRQPVVEPPPFSGSDLCVAGVSVRRARRQVLPVCNLKASASLLDAQPLKARGPSAMPDPAQGPPSPALQRDLGLKEEKGLPLALL
APLRGAAESGGAAQPTRTKAAGKVELPACPCRHVDSQAPNTGVPVAQPAKSWDPNQLNAHPLEPVLRGLKTAEGALRPPPGGKGEGTVCS
RLPHHGHHVAACQTTGTTWDGGPGVCFLRQLLASELPMGPGLPRDPRAPPCLVCRGLLPPAGPCKRCRSFCAAVLQGASFVRLGGRSCSP
RTP

--------------------------------------------------------------
>10172_10172_5_BRD1-TTLL8_BRD1_chr22_50216599_ENST00000542442_TTLL8_chr22_50472891_ENST00000266182_length(transcript)=1935nt_BP=351nt
CCAGTGCCACAAAGCAAACTGCTACACAGCATTCCATGTGACGTGTGCCCAGAAGGCTGGCCTGTACATGAAAATGGAGCCCGTGAAGGA
ACTGACTGGCGGTGGCACCACCTTCTCCGTCAGAAAGACCGCTTACTGTGATGTCCACACGCCTCCAGGCTGCACCCGGAGGCCTCTGAA
TATTTACGGGGATGTCGAAATGAAAAATGGCGTCTGTCGAAAAGAGAGCTCGGTTAAAACGGTCAGGTCCACATCCAAGGTCAGGAAGAA
GGCAAAAAAGGCTAAGAAAGCTCTGGCTGAGCCCTGCGCGGTCCTGCCGACCGTGTGCGCTCCTTATATTCCCCCGCAGAGTGCCAGGCT
CTGCTGAATAGAATCACGTCTGTGAACCCTCAGACGGACATTGACGGGCTCCGGAACATCTGGATTATAAAGCCCGCGGCCAAGTCCCGG
GGCCGAGGTGAGTCCCCTGACATAGTGTGCATGGACCGTGTGGAGGAGATCCTGGAGCTGGCAGCTGCAGACCACCCTCTTTCCAGGGAC
AACAAGTGGGTGGTCCAGAAGTACATCGAGACGCCGCTGCTCATCTGTGACACCAAGTTCGACATCAGACAGTGGTTCCTCGTCACGGAC
TGGAACCCCCTGACCATCTGGTTCTACAAGGAGAGTTACTTGCGGTTCTCAACTCAGCGCTTCTCCCTGGACAAGCTGGACAGCGCCATC
CACCTGTGCAACAACGCCGTCCAGAAGTACCTGAAGAATGATGTGGGCCGCAGCCCCCTGCTGCCCGCACACAACATGTGGACCAGCACC
AGGTTCCAGGAGTACCTGCAGCGCCAGGGCCGTGGCGCCGTGTGGGGCAGCGTCATCTACCCGTCCATGAAGAAGGCCATCGCCCACGCC
ATGAAGGTGGCCCAGGACCACGTGGAGCCTCGCAAGAACAGCTTTGAGCTCTACGGGGCTGACTTCGTCCTTGGGAGGGACTTCAGGCCC
TGGCTGATCGAGATCAATTCCAGCCCCACCATGCACCCGTCCACGCCGGTCACGGCCCAGCTGTGTGCACAGGTGCAGGAGGACACCATC
AAGGTGGCCGTGGACCGCAGCTGTGACATCGGCAACTTCGAGCTCCTGTGGAGGCAGCCGGTGGTTGAGCCGCCCCCATTCAGCGGGTCC
GACCTCTGCGTGGCGGGCGTCAGTGTGAGGAGAGCCAGGAGGCAGGTGCTGCCCGTCTGCAACCTCAAGGCCTCGGCCTCGCTGTTGGAC
GCGCAGCCGCTGAAGGCACGGGGCCCCTCGGCCATGCCAGACCCTGCCCAGGGACCCCCATCACCAGCTCTCCAGCGGGACTTGGGACTG
AAGGAAGAGAAGGGGCTCCCCCTGGCCTTGCTGGCACCCTTAAGGGGGGCAGCCGAGAGCGGTGGAGCCGCACAGCCCACCCGCACCAAA
GCTGCTGGGAAGGTGGAGCTCCCGGCCTGCCCCTGTCGCCACGTGGACAGTCAGGCCCCAAACACCGGTGTCCCCGTAGCCCAGCCCGCC
AAAAGCTGGGATCCAAACCAGCTAAATGCGCACCCGCTGGAGCCTGTGCTGCGGGGCCTGAAGACAGCAGAGGGCGCGCTGCGTCCGCCG
CCCGGAGGAAAAGGAGAGGGCACGGTCTGCAGCCGCCTGCCACACCACGGGCACCACGTGGCCGCCTGCCAGACCACGGGCACCACGTGG
GATGGTGGGCCTGGGGTGTGCTTCCTCCGGCAGCTCCTGGCATCAGAACTGCCCATGGGCCCTGGGCTGCCGAGGGACCCCCGAGCGCCG
CCCTGCCTCGTGTGCCGCGGGCTGCTGCCACCCGCCGGGCCCTGCAAGCGCTGCCGCTCGTTCTGCGCCGCGGTCCTGCAGGGCGCGTCC
TTCGTGCGGCTCGGCGGGCGGAGCTGCAGCCCGCGGACCCCGTGA

>10172_10172_5_BRD1-TTLL8_BRD1_chr22_50216599_ENST00000542442_TTLL8_chr22_50472891_ENST00000266182_length(amino acids)=543AA_BP=16
MRGPADRVRSLYSPAECQALLNRITSVNPQTDIDGLRNIWIIKPAAKSRGRGESPDIVCMDRVEEILELAAADHPLSRDNKWVVQKYIET
PLLICDTKFDIRQWFLVTDWNPLTIWFYKESYLRFSTQRFSLDKLDSAIHLCNNAVQKYLKNDVGRSPLLPAHNMWTSTRFQEYLQRQGR
GAVWGSVIYPSMKKAIAHAMKVAQDHVEPRKNSFELYGADFVLGRDFRPWLIEINSSPTMHPSTPVTAQLCAQVQEDTIKVAVDRSCDIG
NFELLWRQPVVEPPPFSGSDLCVAGVSVRRARRQVLPVCNLKASASLLDAQPLKARGPSAMPDPAQGPPSPALQRDLGLKEEKGLPLALL
APLRGAAESGGAAQPTRTKAAGKVELPACPCRHVDSQAPNTGVPVAQPAKSWDPNQLNAHPLEPVLRGLKTAEGALRPPPGGKGEGTVCS
RLPHHGHHVAACQTTGTTWDGGPGVCFLRQLLASELPMGPGLPRDPRAPPCLVCRGLLPPAGPCKRCRSFCAAVLQGASFVRLGGRSCSP
RTP

--------------------------------------------------------------

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Fusion Gene PPI Analysis for BRD1-TTLL8


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
HgeneBRD1chr22:50216599chr22:50472891ENST00000216267-11231_80455.66666666666671059.0KAT7/HBO1 and histones
HgeneBRD1chr22:50216599chr22:50472891ENST00000404034-21331_80455.66666666666671059.0KAT7/HBO1 and histones
HgeneBRD1chr22:50216599chr22:50472891ENST00000404760-21331_80455.66666666666671190.0KAT7/HBO1 and histones


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for BRD1-TTLL8


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for BRD1-TTLL8


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneBRD1C0036341Schizophrenia5PSYGENET
HgeneBRD1C0005586Bipolar Disorder4PSYGENET
HgeneBRD1C0010606Adenoid Cystic Carcinoma1CTD_human