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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ARHGAP8-MEIS1 (FusionGDB2 ID:HG23779TG4211)

Fusion Gene Summary for ARHGAP8-MEIS1

check button Fusion gene summary
Fusion gene informationFusion gene name: ARHGAP8-MEIS1
Fusion gene ID: hg23779tg4211
HgeneTgene
Gene symbol

ARHGAP8

MEIS1

Gene ID

23779

4211

Gene nameRho GTPase activating protein 8Meis homeobox 1
SynonymsBPGAP1|PP610-
Cytomap('ARHGAP8')('MEIS1')

22q13.31

2p14

Type of geneprotein-codingprotein-coding
Descriptionrho GTPase-activating protein 8BCH domain-containing Cdc42GAP-like proteinBNIP-2 and Cdc42GAP homology domain-containing, proline-rich and Cdc42GAP-like protein subtype-1rho-type GTPase-activating protein 8homeobox protein Meis1Meis1, myeloid ecotropic viral integration site 1 homologWUGSC:H_NH0444B04.1leukemogenic homolog protein
Modification date2020031320200313
UniProtAcc

P85298

O00470

Ensembl transtripts involved in fusion geneENST00000336963, ENST00000356099, 
ENST00000389773, ENST00000389774, 
ENST00000517296, ENST00000469872, 
Fusion gene scores* DoF score5 X 6 X 5=15011 X 10 X 4=440
# samples 513
** MAII scorelog2(5/150*10)=-1.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(13/440*10)=-1.7589919004962
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ARHGAP8 [Title/Abstract] AND MEIS1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointARHGAP8(45241222)-MEIS1(66664869), # samples:1
Anticipated loss of major functional domain due to fusion event.ARHGAP8-MEIS1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ARHGAP8-MEIS1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ARHGAP8-MEIS1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ARHGAP8-MEIS1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ARHGAP8-MEIS1 seems lost the major protein functional domain in Tgene partner, which is a transcription factor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneARHGAP8

GO:0070374

positive regulation of ERK1 and ERK2 cascade

20179103


check buttonFusion gene breakpoints across ARHGAP8 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across MEIS1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-BR-8295-01AARHGAP8chr22

45241222

+MEIS1chr2

66664869

+


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Fusion Gene ORF analysis for ARHGAP8-MEIS1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000336963ENST00000409517ARHGAP8chr22

45241222

+MEIS1chr2

66664869

+
5CDS-intronENST00000336963ENST00000444274ARHGAP8chr22

45241222

+MEIS1chr2

66664869

+
5CDS-intronENST00000336963ENST00000495021ARHGAP8chr22

45241222

+MEIS1chr2

66664869

+
5CDS-intronENST00000356099ENST00000409517ARHGAP8chr22

45241222

+MEIS1chr2

66664869

+
5CDS-intronENST00000356099ENST00000444274ARHGAP8chr22

45241222

+MEIS1chr2

66664869

+
5CDS-intronENST00000356099ENST00000495021ARHGAP8chr22

45241222

+MEIS1chr2

66664869

+
5CDS-intronENST00000389773ENST00000409517ARHGAP8chr22

45241222

+MEIS1chr2

66664869

+
5CDS-intronENST00000389773ENST00000444274ARHGAP8chr22

45241222

+MEIS1chr2

66664869

+
5CDS-intronENST00000389773ENST00000495021ARHGAP8chr22

45241222

+MEIS1chr2

66664869

+
5CDS-intronENST00000389774ENST00000409517ARHGAP8chr22

45241222

+MEIS1chr2

66664869

+
5CDS-intronENST00000389774ENST00000444274ARHGAP8chr22

45241222

+MEIS1chr2

66664869

+
5CDS-intronENST00000389774ENST00000495021ARHGAP8chr22

45241222

+MEIS1chr2

66664869

+
5CDS-intronENST00000517296ENST00000409517ARHGAP8chr22

45241222

+MEIS1chr2

66664869

+
5CDS-intronENST00000517296ENST00000444274ARHGAP8chr22

45241222

+MEIS1chr2

66664869

+
5CDS-intronENST00000517296ENST00000495021ARHGAP8chr22

45241222

+MEIS1chr2

66664869

+
Frame-shiftENST00000336963ENST00000272369ARHGAP8chr22

45241222

+MEIS1chr2

66664869

+
Frame-shiftENST00000336963ENST00000407092ARHGAP8chr22

45241222

+MEIS1chr2

66664869

+
Frame-shiftENST00000336963ENST00000488550ARHGAP8chr22

45241222

+MEIS1chr2

66664869

+
Frame-shiftENST00000336963ENST00000560281ARHGAP8chr22

45241222

+MEIS1chr2

66664869

+
Frame-shiftENST00000356099ENST00000272369ARHGAP8chr22

45241222

+MEIS1chr2

66664869

+
Frame-shiftENST00000356099ENST00000407092ARHGAP8chr22

45241222

+MEIS1chr2

66664869

+
Frame-shiftENST00000356099ENST00000488550ARHGAP8chr22

45241222

+MEIS1chr2

66664869

+
Frame-shiftENST00000356099ENST00000560281ARHGAP8chr22

45241222

+MEIS1chr2

66664869

+
Frame-shiftENST00000389773ENST00000272369ARHGAP8chr22

45241222

+MEIS1chr2

66664869

+
Frame-shiftENST00000389773ENST00000407092ARHGAP8chr22

45241222

+MEIS1chr2

66664869

+
Frame-shiftENST00000389773ENST00000488550ARHGAP8chr22

45241222

+MEIS1chr2

66664869

+
Frame-shiftENST00000389773ENST00000560281ARHGAP8chr22

45241222

+MEIS1chr2

66664869

+
Frame-shiftENST00000389774ENST00000272369ARHGAP8chr22

45241222

+MEIS1chr2

66664869

+
Frame-shiftENST00000389774ENST00000407092ARHGAP8chr22

45241222

+MEIS1chr2

66664869

+
Frame-shiftENST00000389774ENST00000488550ARHGAP8chr22

45241222

+MEIS1chr2

66664869

+
Frame-shiftENST00000389774ENST00000560281ARHGAP8chr22

45241222

+MEIS1chr2

66664869

+
Frame-shiftENST00000517296ENST00000272369ARHGAP8chr22

45241222

+MEIS1chr2

66664869

+
Frame-shiftENST00000517296ENST00000407092ARHGAP8chr22

45241222

+MEIS1chr2

66664869

+
Frame-shiftENST00000517296ENST00000488550ARHGAP8chr22

45241222

+MEIS1chr2

66664869

+
Frame-shiftENST00000517296ENST00000560281ARHGAP8chr22

45241222

+MEIS1chr2

66664869

+
In-frameENST00000336963ENST00000398506ARHGAP8chr22

45241222

+MEIS1chr2

66664869

+
In-frameENST00000356099ENST00000398506ARHGAP8chr22

45241222

+MEIS1chr2

66664869

+
In-frameENST00000389773ENST00000398506ARHGAP8chr22

45241222

+MEIS1chr2

66664869

+
In-frameENST00000389774ENST00000398506ARHGAP8chr22

45241222

+MEIS1chr2

66664869

+
In-frameENST00000517296ENST00000398506ARHGAP8chr22

45241222

+MEIS1chr2

66664869

+
intron-3CDSENST00000469872ENST00000272369ARHGAP8chr22

45241222

+MEIS1chr2

66664869

+
intron-3CDSENST00000469872ENST00000398506ARHGAP8chr22

45241222

+MEIS1chr2

66664869

+
intron-3CDSENST00000469872ENST00000407092ARHGAP8chr22

45241222

+MEIS1chr2

66664869

+
intron-3CDSENST00000469872ENST00000488550ARHGAP8chr22

45241222

+MEIS1chr2

66664869

+
intron-3CDSENST00000469872ENST00000560281ARHGAP8chr22

45241222

+MEIS1chr2

66664869

+
intron-intronENST00000469872ENST00000409517ARHGAP8chr22

45241222

+MEIS1chr2

66664869

+
intron-intronENST00000469872ENST00000444274ARHGAP8chr22

45241222

+MEIS1chr2

66664869

+
intron-intronENST00000469872ENST00000495021ARHGAP8chr22

45241222

+MEIS1chr2

66664869

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000517296ARHGAP8chr2245241222+ENST00000398506MEIS1chr266664869+3614130002684894
ENST00000389773ARHGAP8chr2245241222+ENST00000398506MEIS1chr266664869+3350103602420806
ENST00000389774ARHGAP8chr2245241222+ENST00000398506MEIS1chr266664869+3218904722288738
ENST00000336963ARHGAP8chr2245241222+ENST00000398506MEIS1chr266664869+3080766272150707
ENST00000356099ARHGAP8chr2245241222+ENST00000398506MEIS1chr266664869+3077763242147707

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000517296ENST00000398506ARHGAP8chr2245241222+MEIS1chr266664869+0.0030105480.9969894
ENST00000389773ENST00000398506ARHGAP8chr2245241222+MEIS1chr266664869+0.0021426280.9978574
ENST00000389774ENST00000398506ARHGAP8chr2245241222+MEIS1chr266664869+0.003593890.99640614
ENST00000336963ENST00000398506ARHGAP8chr2245241222+MEIS1chr266664869+0.0021967060.9978033
ENST00000356099ENST00000398506ARHGAP8chr2245241222+MEIS1chr266664869+0.0022387820.99776125

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Fusion Genomic Features for ARHGAP8-MEIS1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
ARHGAP8chr2245241222+MEIS1chr266664868+0.0016438880.99835604
ARHGAP8chr2245241222+MEIS1chr266664868+0.0016438880.99835604

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for ARHGAP8-MEIS1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr22:45241222/chr2:66664869)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ARHGAP8

P85298

MEIS1

O00470

FUNCTION: GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. {ECO:0000250}.FUNCTION: Acts as a transcriptional regulator of PAX6. Acts as a transcriptional activator of PF4 in complex with PBX1 or PBX2. Required for hematopoiesis, megakaryocyte lineage development and vascular patterning. May function as a cofactor for HOXA7 and HOXA9 in the induction of myeloid leukemias. {ECO:0000269|PubMed:12609849}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneARHGAP8chr22:45241222chr2:66664869ENST00000356099+81213_199223434.0DomainCRAL-TRIO
HgeneARHGAP8chr22:45241222chr2:66664869ENST00000389774+91313_199254465.0DomainCRAL-TRIO
TgeneMEIS1chr22:45241222chr2:66664869ENST00000272369013194_24041109.3333333333333Compositional biasNote=Ser/Thr-rich
TgeneMEIS1chr22:45241222chr2:66664869ENST00000272369013242_26941109.3333333333333Compositional biasNote=Asp/Glu-rich (acidic)
TgeneMEIS1chr22:45241222chr2:66664869ENST00000272369013262_26941109.3333333333333Compositional biasNote=Poly-Asp
TgeneMEIS1chr22:45241222chr2:66664869ENST00000398506011194_2400464.0Compositional biasNote=Ser/Thr-rich
TgeneMEIS1chr22:45241222chr2:66664869ENST00000398506011242_2690464.0Compositional biasNote=Asp/Glu-rich (acidic)
TgeneMEIS1chr22:45241222chr2:66664869ENST00000398506011262_2690464.0Compositional biasNote=Poly-Asp
TgeneMEIS1chr22:45241222chr2:66664869ENST00000272369013272_33441109.3333333333333DNA bindingHomeobox%3B TALE-type
TgeneMEIS1chr22:45241222chr2:66664869ENST00000398506011272_3340464.0DNA bindingHomeobox%3B TALE-type
TgeneMEIS1chr22:45241222chr2:66664869ENST00000272369013335_39041109.3333333333333RegionRequired for transcriptional activation
TgeneMEIS1chr22:45241222chr2:66664869ENST00000398506011335_3900464.0RegionRequired for transcriptional activation

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneARHGAP8chr22:45241222chr2:66664869ENST00000356099+812226_412223434.0DomainRho-GAP
HgeneARHGAP8chr22:45241222chr2:66664869ENST00000389774+913226_412254465.0DomainRho-GAP


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Fusion Gene Sequence for ARHGAP8-MEIS1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>6154_6154_1_ARHGAP8-MEIS1_ARHGAP8_chr22_45241222_ENST00000336963_MEIS1_chr2_66664869_ENST00000398506_length(transcript)=3080nt_BP=766nt
GGGGGCCGGCGGGGTCCGTGGCCAGAGCTGCAGAGAGACAAGGCGGCGGCGGCTGCTGTGCTGGGTGCAGTGAGGAAGAGGCCCTCGGTG
GTGCCCATGGCTGGCCAGGATCCTGCGCTGAGCACGAGTCACCCGTTCTACGACGTGGCCAGACATGGCATTCTGCAGGTGGCAGGGGAT
GACCGCTTTGGAAGACGTGTTGTCACGTTCAGCTGCTGCCGGATGCCACCCTCCCACGAGCTGGACCACCAGCGGCTGCTGGAGTATTTG
AAGTACACACTGGACCAATACGTTGAGAACGATTATACCATCGTCTATTTCCACTACGGGCTGAACAGCCGGAACAAGCCTTCCCTGGGC
TGGCTCCAGAGCGCATACAAGGAGTTCGATAGGAAGTACAAGAAGAACTTGAAGGCCCTCTACGTGGTGCACCCCACCAGCTTCATCAAG
GTCCTGTGGAACATCTTGAAGCCCCTCATCAGTCACAAGTTTGGGAAGAAAGTCATCTATTTCAACTACCTGAGTGAGCTCCACGAACAC
CTTAAATACGACCAGCTGGTCATCCCTCCCGAAGTTTTGCGGTACGATGAGAAGCTCCAGAGCCTGCACGAGGGCCGGACGCCGCCTCCC
ACCAAGACACCACCGCCGCGGCCCCCGCTGCCCACACAGCAGTTTGGCGTCAGTCTGCAATACCTCAAAGACAAAAATCAAGGCGAACTC
ATCCCCCCTGTGCTGAGGTTCACAGTGACGTACCTGAGAGAGAAAGACGACGATCTACCCCATTACGGGGGCATGGATGGAGTAGGCATC
CCCTCCACGATGTATGGGGACCCGCATGCAGCCAGGTCCATGCAGCCGGTCCACCACCTGAACCACGGGCCTCCTCTGCACTCGCATCAG
TACCCGCACACAGCTCATACCAACGCCATGGCCCCCAGCATGGGCTCCTCTGTCAATGACGCTTTAAAGAGAGATAAAGATGCCATTTAT
GGACACCCCCTCTTCCCTCTCTTAGCACTGATTTTTGAGAAATGTGAATTAGCTACTTGTACCCCCCGCGAGCCGGGGGTGGCGGGCGGG
GACGTCTGCTCGTCAGAGTCATTCAATGAAGATATAGCCGTGTTCGCCAAACAGATTCGCGCAGAAAAACCTCTATTTTCTTCTAATCCA
GAACTGGATAACTTGATGATTCAAGCCATACAAGTATTAAGGTTTCATCTATTGGAATTAGAGAAGGTACACGAATTATGTGACAATTTC
TGCCACCGGTATATTAGCTGTTTGAAAGGGAAAATGCCTATCGATTTGGTGATAGACGATAGAGAAGGAGGATCAAAATCAGACAGTGAA
GATATAACAAGATCAGCAAATCTAACTGACCAGCCCTCTTGGAACAGAGATCATGATGACACGGCATCTACTCGTTCAGGAGGAACCCCA
GGCCCTTCCAGCGGTGGCCACACGTCACACAGTGGGGACAACAGCAGTGAGCAAGGTGATGGCTTGGACAACAGTGTAGCTTCCCCCAGC
ACAGGTGACGATGATGACCCTGATAAGGACAAAAAGCGTCACAAAAAGCGTGGCATCTTTCCCAAAGTAGCCACAAATATCATGAGGGCG
TGGCTGTTCCAGCATCTAACACACCCTTACCCTTCTGAAGAACAGAAAAAGCAGTTGGCACAAGACACGGGACTCACCATCCTTCAAGTG
AACAATTGGTTTATTAATGCCCGGAGAAGAATAGTGCAGCCCATGATAGACCAGTCCAACCGAGCAGTAAGTCAAGGAACACCTTATAAT
CCTGATGGACAGCCCATGGGAGGTTTCGTAATGGACGGTCAGCAACATATGGGAATTAGAGCACCAGGGCTGCAAAGTATGCCAGGGGAG
TATGTAGCCCGGGGTGGTCCAATGGGTGTGAGTATGGGACAGCCAAGTTATACCCAACCCCAGATGCCCCCCCATCCTGCTCAGCTGCGT
CATGGGCCCCCCATGCATACGTACATTCCTGGACACCCTCACCACCCAACAGTGATGATGCATGGAGGACCGCCCCACCCTGGAATGCCA
ATGTCAGCATCAAGCCCCACAGTTCTTAATACAGGAGACCCAACAATGAGTGGACAAGTCATGGACATTCATGCTCAGTAGCTTAAGGGA
ATATGCATTGTCTGCAATGGTGACTGATTTCAAATCATGTTTTTTCTGCAATGACTGTGGAGTTCCATTCTTGGCATCTACTCTGGACCA
AGGAGCATCCCTAATTCTTCATAGGGACCTTTAAAAAGCAGGAAATACCAACTGAAGTCAATTTGGGGGACATGCTAAATAACTATATAA
GACATTAAGAGAACAAAGAGTGAAATATTGTAAATGCTATTATACTGTTATCCATATTACGTTGTTTCTTATAGATTTTTTAAAAAAAAT
GTGAAATTTTTCCACACTATGTGTGTTGTTTCCATAGCTCTTCACTTCCTCCAGAAGCCTCCTTACATTAAAAAGCCTTACAGTTATCCT
GCAAGGGACAGGAAGGTCTGATTTGCAGGATTTTTAGAGCATTAAAATAACTATCAGGCAGAAGAATCTTTCTTCTCGCCTAGGATTTCA
GCCATGCGCGCGCTCTCTCTCTTTCTCTCTCTTTTCCTCTCTCTCCCTCTTTCTAGCCTGGGGCTTGAATTTGCATGTCTAATTCATTTA
CTCACCATATTTGAATTGGCCTGAACAGATGTAAATCGGGAAGGATGGGAAAAACTGCAGTCATCAACAATGATTAATCAGCTGTTGCAG
GCAGTGTCTTAAGGAGACTGGTAGGAGGAGGCATGGAAACCAAAAGGCCGTGTGTTTAGAAGCCTAATTGTCACATCAAGCATCATTGTC
CCCATGCAACAACCACCACCTTATACATCACTTCCTGTTTTAAGCAGCTCTAAAACATAGACTGAAGATTTATTTTTAATATGTTGACTT
TATTTCTGAGCAAAGCATCGGTCATGTGTGTATTTTTTCATAGTCCCACCTTGGAGCATTTATGTAGACATTGTAAATAAATTTTGTGCA

>6154_6154_1_ARHGAP8-MEIS1_ARHGAP8_chr22_45241222_ENST00000336963_MEIS1_chr2_66664869_ENST00000398506_length(amino acids)=707AA_BP=247
MQRDKAAAAAVLGAVRKRPSVVPMAGQDPALSTSHPFYDVARHGILQVAGDDRFGRRVVTFSCCRMPPSHELDHQRLLEYLKYTLDQYVE
NDYTIVYFHYGLNSRNKPSLGWLQSAYKEFDRKYKKNLKALYVVHPTSFIKVLWNILKPLISHKFGKKVIYFNYLSELHEHLKYDQLVIP
PEVLRYDEKLQSLHEGRTPPPTKTPPPRPPLPTQQFGVSLQYLKDKNQGELIPPVLRFTVTYLREKDDDLPHYGGMDGVGIPSTMYGDPH
AARSMQPVHHLNHGPPLHSHQYPHTAHTNAMAPSMGSSVNDALKRDKDAIYGHPLFPLLALIFEKCELATCTPREPGVAGGDVCSSESFN
EDIAVFAKQIRAEKPLFSSNPELDNLMIQAIQVLRFHLLELEKVHELCDNFCHRYISCLKGKMPIDLVIDDREGGSKSDSEDITRSANLT
DQPSWNRDHDDTASTRSGGTPGPSSGGHTSHSGDNSSEQGDGLDNSVASPSTGDDDDPDKDKKRHKKRGIFPKVATNIMRAWLFQHLTHP
YPSEEQKKQLAQDTGLTILQVNNWFINARRRIVQPMIDQSNRAVSQGTPYNPDGQPMGGFVMDGQQHMGIRAPGLQSMPGEYVARGGPMG

--------------------------------------------------------------
>6154_6154_2_ARHGAP8-MEIS1_ARHGAP8_chr22_45241222_ENST00000356099_MEIS1_chr2_66664869_ENST00000398506_length(transcript)=3077nt_BP=763nt
GGCCGGCGGGGTCCGTGGCCAGAGCTGCAGAGAGACAAGGCGGCGGCGGCTGCTGTGCTGGGTGCAGTGAGGAAGAGGCCCTCGGTGGTG
CCCATGGCTGGCCAGGATCCTGCGCTGAGCACGAGTCACCCGTTCTACGACGTGGCCAGACATGGCATTCTGCAGGTGGCAGGGGATGAC
CGCTTTGGAAGACGTGTTGTCACGTTCAGCTGCTGCCGGATGCCACCCTCCCACGAGCTGGACCACCAGCGGCTGCTGGAGTATTTGAAG
TACACACTGGACCAATACGTTGAGAACGATTATACCATCGTCTATTTCCACTACGGGCTGAACAGCCGGAACAAGCCTTCCCTGGGCTGG
CTCCAGAGCGCATACAAGGAGTTCGATAGGAAGTACAAGAAGAACTTGAAGGCCCTCTACGTGGTGCACCCCACCAGCTTCATCAAGGTC
CTGTGGAACATCTTGAAGCCCCTCATCAGTCACAAGTTTGGGAAGAAAGTCATCTATTTCAACTACCTGAGTGAGCTCCACGAACACCTT
AAATACGACCAGCTGGTCATCCCTCCCGAAGTTTTGCGGTACGATGAGAAGCTCCAGAGCCTGCACGAGGGCCGGACGCCGCCTCCCACC
AAGACACCACCGCCGCGGCCCCCGCTGCCCACACAGCAGTTTGGCGTCAGTCTGCAATACCTCAAAGACAAAAATCAAGGCGAACTCATC
CCCCCTGTGCTGAGGTTCACAGTGACGTACCTGAGAGAGAAAGACGACGATCTACCCCATTACGGGGGCATGGATGGAGTAGGCATCCCC
TCCACGATGTATGGGGACCCGCATGCAGCCAGGTCCATGCAGCCGGTCCACCACCTGAACCACGGGCCTCCTCTGCACTCGCATCAGTAC
CCGCACACAGCTCATACCAACGCCATGGCCCCCAGCATGGGCTCCTCTGTCAATGACGCTTTAAAGAGAGATAAAGATGCCATTTATGGA
CACCCCCTCTTCCCTCTCTTAGCACTGATTTTTGAGAAATGTGAATTAGCTACTTGTACCCCCCGCGAGCCGGGGGTGGCGGGCGGGGAC
GTCTGCTCGTCAGAGTCATTCAATGAAGATATAGCCGTGTTCGCCAAACAGATTCGCGCAGAAAAACCTCTATTTTCTTCTAATCCAGAA
CTGGATAACTTGATGATTCAAGCCATACAAGTATTAAGGTTTCATCTATTGGAATTAGAGAAGGTACACGAATTATGTGACAATTTCTGC
CACCGGTATATTAGCTGTTTGAAAGGGAAAATGCCTATCGATTTGGTGATAGACGATAGAGAAGGAGGATCAAAATCAGACAGTGAAGAT
ATAACAAGATCAGCAAATCTAACTGACCAGCCCTCTTGGAACAGAGATCATGATGACACGGCATCTACTCGTTCAGGAGGAACCCCAGGC
CCTTCCAGCGGTGGCCACACGTCACACAGTGGGGACAACAGCAGTGAGCAAGGTGATGGCTTGGACAACAGTGTAGCTTCCCCCAGCACA
GGTGACGATGATGACCCTGATAAGGACAAAAAGCGTCACAAAAAGCGTGGCATCTTTCCCAAAGTAGCCACAAATATCATGAGGGCGTGG
CTGTTCCAGCATCTAACACACCCTTACCCTTCTGAAGAACAGAAAAAGCAGTTGGCACAAGACACGGGACTCACCATCCTTCAAGTGAAC
AATTGGTTTATTAATGCCCGGAGAAGAATAGTGCAGCCCATGATAGACCAGTCCAACCGAGCAGTAAGTCAAGGAACACCTTATAATCCT
GATGGACAGCCCATGGGAGGTTTCGTAATGGACGGTCAGCAACATATGGGAATTAGAGCACCAGGGCTGCAAAGTATGCCAGGGGAGTAT
GTAGCCCGGGGTGGTCCAATGGGTGTGAGTATGGGACAGCCAAGTTATACCCAACCCCAGATGCCCCCCCATCCTGCTCAGCTGCGTCAT
GGGCCCCCCATGCATACGTACATTCCTGGACACCCTCACCACCCAACAGTGATGATGCATGGAGGACCGCCCCACCCTGGAATGCCAATG
TCAGCATCAAGCCCCACAGTTCTTAATACAGGAGACCCAACAATGAGTGGACAAGTCATGGACATTCATGCTCAGTAGCTTAAGGGAATA
TGCATTGTCTGCAATGGTGACTGATTTCAAATCATGTTTTTTCTGCAATGACTGTGGAGTTCCATTCTTGGCATCTACTCTGGACCAAGG
AGCATCCCTAATTCTTCATAGGGACCTTTAAAAAGCAGGAAATACCAACTGAAGTCAATTTGGGGGACATGCTAAATAACTATATAAGAC
ATTAAGAGAACAAAGAGTGAAATATTGTAAATGCTATTATACTGTTATCCATATTACGTTGTTTCTTATAGATTTTTTAAAAAAAATGTG
AAATTTTTCCACACTATGTGTGTTGTTTCCATAGCTCTTCACTTCCTCCAGAAGCCTCCTTACATTAAAAAGCCTTACAGTTATCCTGCA
AGGGACAGGAAGGTCTGATTTGCAGGATTTTTAGAGCATTAAAATAACTATCAGGCAGAAGAATCTTTCTTCTCGCCTAGGATTTCAGCC
ATGCGCGCGCTCTCTCTCTTTCTCTCTCTTTTCCTCTCTCTCCCTCTTTCTAGCCTGGGGCTTGAATTTGCATGTCTAATTCATTTACTC
ACCATATTTGAATTGGCCTGAACAGATGTAAATCGGGAAGGATGGGAAAAACTGCAGTCATCAACAATGATTAATCAGCTGTTGCAGGCA
GTGTCTTAAGGAGACTGGTAGGAGGAGGCATGGAAACCAAAAGGCCGTGTGTTTAGAAGCCTAATTGTCACATCAAGCATCATTGTCCCC
ATGCAACAACCACCACCTTATACATCACTTCCTGTTTTAAGCAGCTCTAAAACATAGACTGAAGATTTATTTTTAATATGTTGACTTTAT
TTCTGAGCAAAGCATCGGTCATGTGTGTATTTTTTCATAGTCCCACCTTGGAGCATTTATGTAGACATTGTAAATAAATTTTGTGCAAAA

>6154_6154_2_ARHGAP8-MEIS1_ARHGAP8_chr22_45241222_ENST00000356099_MEIS1_chr2_66664869_ENST00000398506_length(amino acids)=707AA_BP=247
MQRDKAAAAAVLGAVRKRPSVVPMAGQDPALSTSHPFYDVARHGILQVAGDDRFGRRVVTFSCCRMPPSHELDHQRLLEYLKYTLDQYVE
NDYTIVYFHYGLNSRNKPSLGWLQSAYKEFDRKYKKNLKALYVVHPTSFIKVLWNILKPLISHKFGKKVIYFNYLSELHEHLKYDQLVIP
PEVLRYDEKLQSLHEGRTPPPTKTPPPRPPLPTQQFGVSLQYLKDKNQGELIPPVLRFTVTYLREKDDDLPHYGGMDGVGIPSTMYGDPH
AARSMQPVHHLNHGPPLHSHQYPHTAHTNAMAPSMGSSVNDALKRDKDAIYGHPLFPLLALIFEKCELATCTPREPGVAGGDVCSSESFN
EDIAVFAKQIRAEKPLFSSNPELDNLMIQAIQVLRFHLLELEKVHELCDNFCHRYISCLKGKMPIDLVIDDREGGSKSDSEDITRSANLT
DQPSWNRDHDDTASTRSGGTPGPSSGGHTSHSGDNSSEQGDGLDNSVASPSTGDDDDPDKDKKRHKKRGIFPKVATNIMRAWLFQHLTHP
YPSEEQKKQLAQDTGLTILQVNNWFINARRRIVQPMIDQSNRAVSQGTPYNPDGQPMGGFVMDGQQHMGIRAPGLQSMPGEYVARGGPMG

--------------------------------------------------------------
>6154_6154_3_ARHGAP8-MEIS1_ARHGAP8_chr22_45241222_ENST00000389773_MEIS1_chr2_66664869_ENST00000398506_length(transcript)=3350nt_BP=1036nt
ATGAGTTCGCCCAGCCTCAGTGACCTGGGCAAGAGAGAGCCGGCCGCCGCCGCGGACGAGCGGGGCACGCAGCAGCGCCGGGCCTGCGCC
AACGCCACCTGGAACAGCATCCACAACGGGGTGATCGCCGTCTTCCAGCGCAAGGGGCTGCCCGACCAGGAGCTCTTCAGCCTCAACGAG
GGCGTCCGGCAGCTGTTGAAGACAGAGCTGGGGTCCTTCTTCACGGAGTACCTGCAGAACCAGCTGCTGACAAAAGGCATGGTGATCCTT
CGGGACAAGATTCGCTTCTATGAGGAGCTGCAGAGAGACAAGGCGGCGGCGGCTGCTGTGCTGGGTGCAGTGAGGAAGAGGCCCTCGGTG
GTGCCCATGGCTGGCCAGGATCCTGCGCTGAGCACGAGTCACCCGTTCTACGACGTGGCCAGACATGGCATTCTGCAGGTGGCAGGGGAT
GACCGCTTTGGAAGACGTGTTGTCACGTTCAGCTGCTGCCGGATGCCACCCTCCCACGAGCTGGACCACCAGCGGCTGCTGGAGTATTTG
AAGTACACACTGGACCAATACGTTGAGAACGATTATACCATCGTCTATTTCCACTACGGGCTGAACAGCCGGAACAAGCCTTCCCTGGGC
TGGCTCCAGAGCGCATACAAGGAGTTCGATAGGAAGTACAAGAAGAACTTGAAGGCCCTCTACGTGGTGCACCCCACCAGCTTCATCAAG
GTCCTGTGGAACATCTTGAAGCCCCTCATCAGTCACAAGTTTGGGAAGAAAGTCATCTATTTCAACTACCTGAGTGAGCTCCACGAACAC
CTTAAATACGACCAGCTGGTCATCCCTCCCGAAGTTTTGCGGTACGATGAGAAGCTCCAGAGCCTGCACGAGGGCCGGACGCCGCCTCCC
ACCAAGACACCACCGCCGCGGCCCCCGCTGCCCACACAGCAGTTTGGCGTCAGTCTGCAATACCTCAAAGACAAAAATCAAGGCGAACTC
ATCCCCCCTGTGCTGAGGTTCACAGTGACGTACCTGAGAGAGAAAGACGACGATCTACCCCATTACGGGGGCATGGATGGAGTAGGCATC
CCCTCCACGATGTATGGGGACCCGCATGCAGCCAGGTCCATGCAGCCGGTCCACCACCTGAACCACGGGCCTCCTCTGCACTCGCATCAG
TACCCGCACACAGCTCATACCAACGCCATGGCCCCCAGCATGGGCTCCTCTGTCAATGACGCTTTAAAGAGAGATAAAGATGCCATTTAT
GGACACCCCCTCTTCCCTCTCTTAGCACTGATTTTTGAGAAATGTGAATTAGCTACTTGTACCCCCCGCGAGCCGGGGGTGGCGGGCGGG
GACGTCTGCTCGTCAGAGTCATTCAATGAAGATATAGCCGTGTTCGCCAAACAGATTCGCGCAGAAAAACCTCTATTTTCTTCTAATCCA
GAACTGGATAACTTGATGATTCAAGCCATACAAGTATTAAGGTTTCATCTATTGGAATTAGAGAAGGTACACGAATTATGTGACAATTTC
TGCCACCGGTATATTAGCTGTTTGAAAGGGAAAATGCCTATCGATTTGGTGATAGACGATAGAGAAGGAGGATCAAAATCAGACAGTGAA
GATATAACAAGATCAGCAAATCTAACTGACCAGCCCTCTTGGAACAGAGATCATGATGACACGGCATCTACTCGTTCAGGAGGAACCCCA
GGCCCTTCCAGCGGTGGCCACACGTCACACAGTGGGGACAACAGCAGTGAGCAAGGTGATGGCTTGGACAACAGTGTAGCTTCCCCCAGC
ACAGGTGACGATGATGACCCTGATAAGGACAAAAAGCGTCACAAAAAGCGTGGCATCTTTCCCAAAGTAGCCACAAATATCATGAGGGCG
TGGCTGTTCCAGCATCTAACACACCCTTACCCTTCTGAAGAACAGAAAAAGCAGTTGGCACAAGACACGGGACTCACCATCCTTCAAGTG
AACAATTGGTTTATTAATGCCCGGAGAAGAATAGTGCAGCCCATGATAGACCAGTCCAACCGAGCAGTAAGTCAAGGAACACCTTATAAT
CCTGATGGACAGCCCATGGGAGGTTTCGTAATGGACGGTCAGCAACATATGGGAATTAGAGCACCAGGGCTGCAAAGTATGCCAGGGGAG
TATGTAGCCCGGGGTGGTCCAATGGGTGTGAGTATGGGACAGCCAAGTTATACCCAACCCCAGATGCCCCCCCATCCTGCTCAGCTGCGT
CATGGGCCCCCCATGCATACGTACATTCCTGGACACCCTCACCACCCAACAGTGATGATGCATGGAGGACCGCCCCACCCTGGAATGCCA
ATGTCAGCATCAAGCCCCACAGTTCTTAATACAGGAGACCCAACAATGAGTGGACAAGTCATGGACATTCATGCTCAGTAGCTTAAGGGA
ATATGCATTGTCTGCAATGGTGACTGATTTCAAATCATGTTTTTTCTGCAATGACTGTGGAGTTCCATTCTTGGCATCTACTCTGGACCA
AGGAGCATCCCTAATTCTTCATAGGGACCTTTAAAAAGCAGGAAATACCAACTGAAGTCAATTTGGGGGACATGCTAAATAACTATATAA
GACATTAAGAGAACAAAGAGTGAAATATTGTAAATGCTATTATACTGTTATCCATATTACGTTGTTTCTTATAGATTTTTTAAAAAAAAT
GTGAAATTTTTCCACACTATGTGTGTTGTTTCCATAGCTCTTCACTTCCTCCAGAAGCCTCCTTACATTAAAAAGCCTTACAGTTATCCT
GCAAGGGACAGGAAGGTCTGATTTGCAGGATTTTTAGAGCATTAAAATAACTATCAGGCAGAAGAATCTTTCTTCTCGCCTAGGATTTCA
GCCATGCGCGCGCTCTCTCTCTTTCTCTCTCTTTTCCTCTCTCTCCCTCTTTCTAGCCTGGGGCTTGAATTTGCATGTCTAATTCATTTA
CTCACCATATTTGAATTGGCCTGAACAGATGTAAATCGGGAAGGATGGGAAAAACTGCAGTCATCAACAATGATTAATCAGCTGTTGCAG
GCAGTGTCTTAAGGAGACTGGTAGGAGGAGGCATGGAAACCAAAAGGCCGTGTGTTTAGAAGCCTAATTGTCACATCAAGCATCATTGTC
CCCATGCAACAACCACCACCTTATACATCACTTCCTGTTTTAAGCAGCTCTAAAACATAGACTGAAGATTTATTTTTAATATGTTGACTT
TATTTCTGAGCAAAGCATCGGTCATGTGTGTATTTTTTCATAGTCCCACCTTGGAGCATTTATGTAGACATTGTAAATAAATTTTGTGCA

>6154_6154_3_ARHGAP8-MEIS1_ARHGAP8_chr22_45241222_ENST00000389773_MEIS1_chr2_66664869_ENST00000398506_length(amino acids)=806AA_BP=346
MSSPSLSDLGKREPAAAADERGTQQRRACANATWNSIHNGVIAVFQRKGLPDQELFSLNEGVRQLLKTELGSFFTEYLQNQLLTKGMVIL
RDKIRFYEELQRDKAAAAAVLGAVRKRPSVVPMAGQDPALSTSHPFYDVARHGILQVAGDDRFGRRVVTFSCCRMPPSHELDHQRLLEYL
KYTLDQYVENDYTIVYFHYGLNSRNKPSLGWLQSAYKEFDRKYKKNLKALYVVHPTSFIKVLWNILKPLISHKFGKKVIYFNYLSELHEH
LKYDQLVIPPEVLRYDEKLQSLHEGRTPPPTKTPPPRPPLPTQQFGVSLQYLKDKNQGELIPPVLRFTVTYLREKDDDLPHYGGMDGVGI
PSTMYGDPHAARSMQPVHHLNHGPPLHSHQYPHTAHTNAMAPSMGSSVNDALKRDKDAIYGHPLFPLLALIFEKCELATCTPREPGVAGG
DVCSSESFNEDIAVFAKQIRAEKPLFSSNPELDNLMIQAIQVLRFHLLELEKVHELCDNFCHRYISCLKGKMPIDLVIDDREGGSKSDSE
DITRSANLTDQPSWNRDHDDTASTRSGGTPGPSSGGHTSHSGDNSSEQGDGLDNSVASPSTGDDDDPDKDKKRHKKRGIFPKVATNIMRA
WLFQHLTHPYPSEEQKKQLAQDTGLTILQVNNWFINARRRIVQPMIDQSNRAVSQGTPYNPDGQPMGGFVMDGQQHMGIRAPGLQSMPGE

--------------------------------------------------------------
>6154_6154_4_ARHGAP8-MEIS1_ARHGAP8_chr22_45241222_ENST00000389774_MEIS1_chr2_66664869_ENST00000398506_length(transcript)=3218nt_BP=904nt
ACGTCCGGGGAGGGGCCAGGTGAGCGGCAGACCCGGCACGCAGGTGGGGGCCGGCGGGGTCCGTGGCCAGAGCTGCAGAGAGACAAGGCG
GCGGCGGCTGCTGTGCTGGGTGCAGTGAGGAAGAGGCCCTCGGTGGTGCCCATGGCTGGCCAGGATCCTGCGCTGAGCACGAGTCACCCG
TTCTACGACGTGGCCAGACATGGCATTCTGCAGGTGGCAGGGGATGACCGCTTTGGAAGACGTGTTGTCACGTTCAGCTGCTGCCGGATG
CCACCCTCCCACGAGCTGGACCACCAGCGGCTGCTGGAGTATTTGAAGTACACACTGGACCAATACGTTGAGAACGATTATACCATCGTC
TATTTCCACTACGGGCTGAACAGCCGGAACAAGCCTTCCCTGGGCTGGCTCCAGAGCGCATACAAGGAGTTCGATAGGAAAGACGGGGAT
CTCACTATGTGGCCCAGGCTGGTCTCGAACTCCAAGCTCAAGCGATCCTCCCACCTCAGCCTCCCAAAGTACTGGGATTACAGGTACAAG
AAGAACTTGAAGGCCCTCTACGTGGTGCACCCCACCAGCTTCATCAAGGTCCTGTGGAACATCTTGAAGCCCCTCATCAGTCACAAGTTT
GGGAAGAAAGTCATCTATTTCAACTACCTGAGTGAGCTCCACGAACACCTTAAATACGACCAGCTGGTCATCCCTCCCGAAGTTTTGCGG
TACGATGAGAAGCTCCAGAGCCTGCACGAGGGCCGGACGCCGCCTCCCACCAAGACACCACCGCCGCGGCCCCCGCTGCCCACACAGCAG
TTTGGCGTCAGTCTGCAATACCTCAAAGACAAAAATCAAGGCGAACTCATCCCCCCTGTGCTGAGGTTCACAGTGACGTACCTGAGAGAG
AAAGACGACGATCTACCCCATTACGGGGGCATGGATGGAGTAGGCATCCCCTCCACGATGTATGGGGACCCGCATGCAGCCAGGTCCATG
CAGCCGGTCCACCACCTGAACCACGGGCCTCCTCTGCACTCGCATCAGTACCCGCACACAGCTCATACCAACGCCATGGCCCCCAGCATG
GGCTCCTCTGTCAATGACGCTTTAAAGAGAGATAAAGATGCCATTTATGGACACCCCCTCTTCCCTCTCTTAGCACTGATTTTTGAGAAA
TGTGAATTAGCTACTTGTACCCCCCGCGAGCCGGGGGTGGCGGGCGGGGACGTCTGCTCGTCAGAGTCATTCAATGAAGATATAGCCGTG
TTCGCCAAACAGATTCGCGCAGAAAAACCTCTATTTTCTTCTAATCCAGAACTGGATAACTTGATGATTCAAGCCATACAAGTATTAAGG
TTTCATCTATTGGAATTAGAGAAGGTACACGAATTATGTGACAATTTCTGCCACCGGTATATTAGCTGTTTGAAAGGGAAAATGCCTATC
GATTTGGTGATAGACGATAGAGAAGGAGGATCAAAATCAGACAGTGAAGATATAACAAGATCAGCAAATCTAACTGACCAGCCCTCTTGG
AACAGAGATCATGATGACACGGCATCTACTCGTTCAGGAGGAACCCCAGGCCCTTCCAGCGGTGGCCACACGTCACACAGTGGGGACAAC
AGCAGTGAGCAAGGTGATGGCTTGGACAACAGTGTAGCTTCCCCCAGCACAGGTGACGATGATGACCCTGATAAGGACAAAAAGCGTCAC
AAAAAGCGTGGCATCTTTCCCAAAGTAGCCACAAATATCATGAGGGCGTGGCTGTTCCAGCATCTAACACACCCTTACCCTTCTGAAGAA
CAGAAAAAGCAGTTGGCACAAGACACGGGACTCACCATCCTTCAAGTGAACAATTGGTTTATTAATGCCCGGAGAAGAATAGTGCAGCCC
ATGATAGACCAGTCCAACCGAGCAGTAAGTCAAGGAACACCTTATAATCCTGATGGACAGCCCATGGGAGGTTTCGTAATGGACGGTCAG
CAACATATGGGAATTAGAGCACCAGGGCTGCAAAGTATGCCAGGGGAGTATGTAGCCCGGGGTGGTCCAATGGGTGTGAGTATGGGACAG
CCAAGTTATACCCAACCCCAGATGCCCCCCCATCCTGCTCAGCTGCGTCATGGGCCCCCCATGCATACGTACATTCCTGGACACCCTCAC
CACCCAACAGTGATGATGCATGGAGGACCGCCCCACCCTGGAATGCCAATGTCAGCATCAAGCCCCACAGTTCTTAATACAGGAGACCCA
ACAATGAGTGGACAAGTCATGGACATTCATGCTCAGTAGCTTAAGGGAATATGCATTGTCTGCAATGGTGACTGATTTCAAATCATGTTT
TTTCTGCAATGACTGTGGAGTTCCATTCTTGGCATCTACTCTGGACCAAGGAGCATCCCTAATTCTTCATAGGGACCTTTAAAAAGCAGG
AAATACCAACTGAAGTCAATTTGGGGGACATGCTAAATAACTATATAAGACATTAAGAGAACAAAGAGTGAAATATTGTAAATGCTATTA
TACTGTTATCCATATTACGTTGTTTCTTATAGATTTTTTAAAAAAAATGTGAAATTTTTCCACACTATGTGTGTTGTTTCCATAGCTCTT
CACTTCCTCCAGAAGCCTCCTTACATTAAAAAGCCTTACAGTTATCCTGCAAGGGACAGGAAGGTCTGATTTGCAGGATTTTTAGAGCAT
TAAAATAACTATCAGGCAGAAGAATCTTTCTTCTCGCCTAGGATTTCAGCCATGCGCGCGCTCTCTCTCTTTCTCTCTCTTTTCCTCTCT
CTCCCTCTTTCTAGCCTGGGGCTTGAATTTGCATGTCTAATTCATTTACTCACCATATTTGAATTGGCCTGAACAGATGTAAATCGGGAA
GGATGGGAAAAACTGCAGTCATCAACAATGATTAATCAGCTGTTGCAGGCAGTGTCTTAAGGAGACTGGTAGGAGGAGGCATGGAAACCA
AAAGGCCGTGTGTTTAGAAGCCTAATTGTCACATCAAGCATCATTGTCCCCATGCAACAACCACCACCTTATACATCACTTCCTGTTTTA
AGCAGCTCTAAAACATAGACTGAAGATTTATTTTTAATATGTTGACTTTATTTCTGAGCAAAGCATCGGTCATGTGTGTATTTTTTCATA

>6154_6154_4_ARHGAP8-MEIS1_ARHGAP8_chr22_45241222_ENST00000389774_MEIS1_chr2_66664869_ENST00000398506_length(amino acids)=738AA_BP=125
MQRDKAAAAAVLGAVRKRPSVVPMAGQDPALSTSHPFYDVARHGILQVAGDDRFGRRVVTFSCCRMPPSHELDHQRLLEYLKYTLDQYVE
NDYTIVYFHYGLNSRNKPSLGWLQSAYKEFDRKDGDLTMWPRLVSNSKLKRSSHLSLPKYWDYRYKKNLKALYVVHPTSFIKVLWNILKP
LISHKFGKKVIYFNYLSELHEHLKYDQLVIPPEVLRYDEKLQSLHEGRTPPPTKTPPPRPPLPTQQFGVSLQYLKDKNQGELIPPVLRFT
VTYLREKDDDLPHYGGMDGVGIPSTMYGDPHAARSMQPVHHLNHGPPLHSHQYPHTAHTNAMAPSMGSSVNDALKRDKDAIYGHPLFPLL
ALIFEKCELATCTPREPGVAGGDVCSSESFNEDIAVFAKQIRAEKPLFSSNPELDNLMIQAIQVLRFHLLELEKVHELCDNFCHRYISCL
KGKMPIDLVIDDREGGSKSDSEDITRSANLTDQPSWNRDHDDTASTRSGGTPGPSSGGHTSHSGDNSSEQGDGLDNSVASPSTGDDDDPD
KDKKRHKKRGIFPKVATNIMRAWLFQHLTHPYPSEEQKKQLAQDTGLTILQVNNWFINARRRIVQPMIDQSNRAVSQGTPYNPDGQPMGG
FVMDGQQHMGIRAPGLQSMPGEYVARGGPMGVSMGQPSYTQPQMPPHPAQLRHGPPMHTYIPGHPHHPTVMMHGGPPHPGMPMSASSPTV

--------------------------------------------------------------
>6154_6154_5_ARHGAP8-MEIS1_ARHGAP8_chr22_45241222_ENST00000517296_MEIS1_chr2_66664869_ENST00000398506_length(transcript)=3614nt_BP=1300nt
ATGAGGACTCTCCGCAGGTTGAAGTTCATGAGTTCGCCCAGCCTCAGTGACCTGGGCAAGAGAGAGCCGGCCGCCGCCGCGGACGAGCGG
GGCACGCAGCAGCGCCGGGCCTGCGCCAACGCCACCTGGAACAGCATCCACAACGGGGTGATCGCCGTCTTCCAGCGCAAGGGGCTGCCC
GACCAGGAGCTCTTCAGCCTCAACGAGGGCGTCCGGCAGCTGTTGAAGACAGAGCTGGGGTCCTTCTTCACGGAGTACCTGCAGAACCAG
CTGCTGACAAAAGGCATGGTGATCCTTCGGGACAAGATTCGCTTCTATGAGGGACAGAAGCTGCTGGACTCACTGGCAGAGACCTGGGAC
TTCTTCTTCAGTGACGTGCTGCCCATGCTGCAGGCCATCTTCTACCCGGTGCAGGGCAAGGAGCCATCGGTGCGCCAGCTGGCCCTGCTG
CACTTCCGGAATGCCATCACCCTCAGTGTGAAGCTAGAGGATGCGCTGGCCCGGGCCCATGCCCGTGTGCCCCCTGCCATCGTGCAGATG
CTGCTGGTGCTGCAGGGGGTACATGAGTCCAGGGGCGTGACTGAGGACTACCTGCGCCTGGAGACGCTGGTCCAGAAGGTGGTGTCGCCA
TACCTGGGCACCTACGGCCTCCACTCCAGCGAGGGGCCCTTCACCCATTCCTGCATCCTGGAGCTGCAGAGAGACAAGGCGGCGGCGGCT
GCTGTGCTGGGTGCAGTGAGGAAGAGGCCCTCGGTGGTGCCCATGGCTGGCCAGGATCCTGCGCTGAGCACGAGTCACCCGTTCTACGAC
GTGGCCAGACATGGCATTCTGCAGGTGGCAGGGGATGACCGCTTTGGAAGACGTGTTGTCACGTTCAGCTGCTGCCGGATGCCACCCTCC
CACGAGCTGGACCACCAGCGGCTGCTGGAGTACAAGAAGAACTTGAAGGCCCTCTACGTGGTGCACCCCACCAGCTTCATCAAGGTCCTG
TGGAACATCTTGAAGCCCCTCATCAGTCACAAGTTTGGGAAGAAAGTCATCTATTTCAACTACCTGAGTGAGCTCCACGAACACCTTAAA
TACGACCAGCTGGTCATCCCTCCCGAAGTTTTGCGGTACGATGAGAAGCTCCAGAGCCTGCACGAGGGCCGGACGCCGCCTCCCACCAAG
ACACCACCGCCGCGGCCCCCGCTGCCCACACAGCAGTTTGGCGTCAGTCTGCAATACCTCAAAGACAAAAATCAAGGCGAACTCATCCCC
CCTGTGCTGAGGTTCACAGTGACGTACCTGAGAGAGAAAGACGACGATCTACCCCATTACGGGGGCATGGATGGAGTAGGCATCCCCTCC
ACGATGTATGGGGACCCGCATGCAGCCAGGTCCATGCAGCCGGTCCACCACCTGAACCACGGGCCTCCTCTGCACTCGCATCAGTACCCG
CACACAGCTCATACCAACGCCATGGCCCCCAGCATGGGCTCCTCTGTCAATGACGCTTTAAAGAGAGATAAAGATGCCATTTATGGACAC
CCCCTCTTCCCTCTCTTAGCACTGATTTTTGAGAAATGTGAATTAGCTACTTGTACCCCCCGCGAGCCGGGGGTGGCGGGCGGGGACGTC
TGCTCGTCAGAGTCATTCAATGAAGATATAGCCGTGTTCGCCAAACAGATTCGCGCAGAAAAACCTCTATTTTCTTCTAATCCAGAACTG
GATAACTTGATGATTCAAGCCATACAAGTATTAAGGTTTCATCTATTGGAATTAGAGAAGGTACACGAATTATGTGACAATTTCTGCCAC
CGGTATATTAGCTGTTTGAAAGGGAAAATGCCTATCGATTTGGTGATAGACGATAGAGAAGGAGGATCAAAATCAGACAGTGAAGATATA
ACAAGATCAGCAAATCTAACTGACCAGCCCTCTTGGAACAGAGATCATGATGACACGGCATCTACTCGTTCAGGAGGAACCCCAGGCCCT
TCCAGCGGTGGCCACACGTCACACAGTGGGGACAACAGCAGTGAGCAAGGTGATGGCTTGGACAACAGTGTAGCTTCCCCCAGCACAGGT
GACGATGATGACCCTGATAAGGACAAAAAGCGTCACAAAAAGCGTGGCATCTTTCCCAAAGTAGCCACAAATATCATGAGGGCGTGGCTG
TTCCAGCATCTAACACACCCTTACCCTTCTGAAGAACAGAAAAAGCAGTTGGCACAAGACACGGGACTCACCATCCTTCAAGTGAACAAT
TGGTTTATTAATGCCCGGAGAAGAATAGTGCAGCCCATGATAGACCAGTCCAACCGAGCAGTAAGTCAAGGAACACCTTATAATCCTGAT
GGACAGCCCATGGGAGGTTTCGTAATGGACGGTCAGCAACATATGGGAATTAGAGCACCAGGGCTGCAAAGTATGCCAGGGGAGTATGTA
GCCCGGGGTGGTCCAATGGGTGTGAGTATGGGACAGCCAAGTTATACCCAACCCCAGATGCCCCCCCATCCTGCTCAGCTGCGTCATGGG
CCCCCCATGCATACGTACATTCCTGGACACCCTCACCACCCAACAGTGATGATGCATGGAGGACCGCCCCACCCTGGAATGCCAATGTCA
GCATCAAGCCCCACAGTTCTTAATACAGGAGACCCAACAATGAGTGGACAAGTCATGGACATTCATGCTCAGTAGCTTAAGGGAATATGC
ATTGTCTGCAATGGTGACTGATTTCAAATCATGTTTTTTCTGCAATGACTGTGGAGTTCCATTCTTGGCATCTACTCTGGACCAAGGAGC
ATCCCTAATTCTTCATAGGGACCTTTAAAAAGCAGGAAATACCAACTGAAGTCAATTTGGGGGACATGCTAAATAACTATATAAGACATT
AAGAGAACAAAGAGTGAAATATTGTAAATGCTATTATACTGTTATCCATATTACGTTGTTTCTTATAGATTTTTTAAAAAAAATGTGAAA
TTTTTCCACACTATGTGTGTTGTTTCCATAGCTCTTCACTTCCTCCAGAAGCCTCCTTACATTAAAAAGCCTTACAGTTATCCTGCAAGG
GACAGGAAGGTCTGATTTGCAGGATTTTTAGAGCATTAAAATAACTATCAGGCAGAAGAATCTTTCTTCTCGCCTAGGATTTCAGCCATG
CGCGCGCTCTCTCTCTTTCTCTCTCTTTTCCTCTCTCTCCCTCTTTCTAGCCTGGGGCTTGAATTTGCATGTCTAATTCATTTACTCACC
ATATTTGAATTGGCCTGAACAGATGTAAATCGGGAAGGATGGGAAAAACTGCAGTCATCAACAATGATTAATCAGCTGTTGCAGGCAGTG
TCTTAAGGAGACTGGTAGGAGGAGGCATGGAAACCAAAAGGCCGTGTGTTTAGAAGCCTAATTGTCACATCAAGCATCATTGTCCCCATG
CAACAACCACCACCTTATACATCACTTCCTGTTTTAAGCAGCTCTAAAACATAGACTGAAGATTTATTTTTAATATGTTGACTTTATTTC
TGAGCAAAGCATCGGTCATGTGTGTATTTTTTCATAGTCCCACCTTGGAGCATTTATGTAGACATTGTAAATAAATTTTGTGCAAAAAGG

>6154_6154_5_ARHGAP8-MEIS1_ARHGAP8_chr22_45241222_ENST00000517296_MEIS1_chr2_66664869_ENST00000398506_length(amino acids)=894AA_BP=434
MRTLRRLKFMSSPSLSDLGKREPAAAADERGTQQRRACANATWNSIHNGVIAVFQRKGLPDQELFSLNEGVRQLLKTELGSFFTEYLQNQ
LLTKGMVILRDKIRFYEGQKLLDSLAETWDFFFSDVLPMLQAIFYPVQGKEPSVRQLALLHFRNAITLSVKLEDALARAHARVPPAIVQM
LLVLQGVHESRGVTEDYLRLETLVQKVVSPYLGTYGLHSSEGPFTHSCILELQRDKAAAAAVLGAVRKRPSVVPMAGQDPALSTSHPFYD
VARHGILQVAGDDRFGRRVVTFSCCRMPPSHELDHQRLLEYKKNLKALYVVHPTSFIKVLWNILKPLISHKFGKKVIYFNYLSELHEHLK
YDQLVIPPEVLRYDEKLQSLHEGRTPPPTKTPPPRPPLPTQQFGVSLQYLKDKNQGELIPPVLRFTVTYLREKDDDLPHYGGMDGVGIPS
TMYGDPHAARSMQPVHHLNHGPPLHSHQYPHTAHTNAMAPSMGSSVNDALKRDKDAIYGHPLFPLLALIFEKCELATCTPREPGVAGGDV
CSSESFNEDIAVFAKQIRAEKPLFSSNPELDNLMIQAIQVLRFHLLELEKVHELCDNFCHRYISCLKGKMPIDLVIDDREGGSKSDSEDI
TRSANLTDQPSWNRDHDDTASTRSGGTPGPSSGGHTSHSGDNSSEQGDGLDNSVASPSTGDDDDPDKDKKRHKKRGIFPKVATNIMRAWL
FQHLTHPYPSEEQKKQLAQDTGLTILQVNNWFINARRRIVQPMIDQSNRAVSQGTPYNPDGQPMGGFVMDGQQHMGIRAPGLQSMPGEYV

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Fusion Gene PPI Analysis for ARHGAP8-MEIS1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
TgeneMEIS1chr22:45241222chr2:66664869ENST00000272369013299_3294.01109.3333333333333DNA
TgeneMEIS1chr22:45241222chr2:66664869ENST00000398506011299_3290464.0DNA


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ARHGAP8-MEIS1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ARHGAP8-MEIS1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneC0035258Restless Legs Syndrome2CTD_human
TgeneC0006142Malignant neoplasm of breast1CTD_human
TgeneC0021603Sleep Initiation and Maintenance Disorders1CTD_human
TgeneC0033139Primary Insomnia1CTD_human
TgeneC0270541Rebound Insomnia1CTD_human
TgeneC0349255Nonorganic Insomnia1CTD_human
TgeneC0393759Transient Insomnia1CTD_human
TgeneC0541798Early Awakening1CTD_human
TgeneC0678222Breast Carcinoma1CTD_human
TgeneC0751249Chronic Insomnia1CTD_human
TgeneC0751250Psychophysiological Insomnia1CTD_human
TgeneC0751251Secondary Insomnia1CTD_human
TgeneC0751252Sleep Initiation Dysfunction1CTD_human
TgeneC0917801Sleeplessness1CTD_human
TgeneC1257931Mammary Neoplasms, Human1CTD_human
TgeneC1458155Mammary Neoplasms1CTD_human
TgeneC4704874Mammary Carcinoma, Human1CTD_human