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![]() | Fusion Gene Summary |
![]() | Fusion Gene ORF analysis |
![]() | Fusion Genomic Features |
![]() | Fusion Protein Features |
![]() | Fusion Gene Sequence |
![]() | Fusion Gene PPI analysis |
![]() | Related Drugs |
![]() | Related Diseases |
Fusion gene:ALOX5-PRSS1 (FusionGDB2 ID:HG240TG5644) |
Fusion Gene Summary for ALOX5-PRSS1 |
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Fusion gene information | Fusion gene name: ALOX5-PRSS1 | Fusion gene ID: hg240tg5644 | Hgene | Tgene | Gene symbol | ALOX5 | PRSS1 | Gene ID | 240 | 5644 |
Gene name | arachidonate 5-lipoxygenase | serine protease 1 | |
Synonyms | 5-LO|5-LOX|5LPG|LOG5 | TRP1|TRY1|TRY4|TRYP1 | |
Cytomap | ('ALOX5')('PRSS1') 10q11.21 | 7q34 | |
Type of gene | protein-coding | protein-coding | |
Description | arachidonate 5-lipoxygenaseLOX-5arachidonic 5-lipoxygenase alpha-10 isoformarachidonic 5-lipoxygenase delta-10-13 isoformarachidonic 5-lipoxygenase delta-13 isoformarachidonic 5-lipoxygenase delta-p10 isoformarachidonic acid 5-lipoxygenaseleukotrie | trypsin-1TCR V beta 4.1beta-trypsincationic trypsinogendigestive zymogennonfunctional trypsin 1protease, serine 1trypsinogen 1trypsinogen A | |
Modification date | 20200327 | 20200321 | |
UniProtAcc | . | . | |
Ensembl transtripts involved in fusion gene | ENST00000374391, ENST00000542434, ENST00000493336, | ||
Fusion gene scores | * DoF score | 3 X 3 X 1=9 | 12 X 17 X 5=1020 |
# samples | 3 | 15 | |
** MAII score | log2(3/9*10)=1.73696559416621 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(15/1020*10)=-2.76553474636298 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: ALOX5 [Title/Abstract] AND PRSS1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Most frequent breakpoint | ALOX5(45924120)-PRSS1(142460859), # samples:1 | ||
Anticipated loss of major functional domain due to fusion event. | ALOX5-PRSS1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. ALOX5-PRSS1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. ALOX5-PRSS1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. ALOX5-PRSS1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. ALOX5-PRSS1 seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF. ALOX5-PRSS1 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF. ALOX5-PRSS1 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | ALOX5 | GO:0019370 | leukotriene biosynthetic process | 21233389 |
Hgene | ALOX5 | GO:0050728 | negative regulation of inflammatory response | 21206090 |
![]() * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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![]() * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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![]() * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
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Fusion Gene ORF analysis for ALOX5-PRSS1 |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
ENST00000542434 | ENST00000486171 | ALOX5 | chr10 | 45924120 | + | PRSS1 | chr7 | 142460859 | + | 0.35718125 | 0.6428187 |
ENST00000374391 | ENST00000486171 | ALOX5 | chr10 | 45924120 | + | PRSS1 | chr7 | 142460859 | + | 0.4857299 | 0.51427007 |
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Fusion Genomic Features for ALOX5-PRSS1 |
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Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
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Fusion Protein Features for ALOX5-PRSS1 |
![]() Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr10:45924120/chr7:142460859) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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Hgene | Tgene |
. | . |
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. | FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Tgene | PRSS1 | chr10:45924120 | chr7:142460859 | ENST00000311737 | 0 | 5 | 24_244 | 0 | 248.0 | Domain | Peptidase S1 |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | ALOX5 | chr10:45924120 | chr7:142460859 | ENST00000374391 | + | 1 | 14 | 119_674 | 0 | 675.0 | Domain | Lipoxygenase |
Hgene | ALOX5 | chr10:45924120 | chr7:142460859 | ENST00000374391 | + | 1 | 14 | 2_118 | 0 | 675.0 | Domain | PLAT |
Hgene | ALOX5 | chr10:45924120 | chr7:142460859 | ENST00000542434 | + | 1 | 13 | 119_674 | 0 | 618.0 | Domain | Lipoxygenase |
Hgene | ALOX5 | chr10:45924120 | chr7:142460859 | ENST00000542434 | + | 1 | 13 | 2_118 | 0 | 618.0 | Domain | PLAT |
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Fusion Gene Sequence for ALOX5-PRSS1 |
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>4100_4100_1_ALOX5-PRSS1_ALOX5_chr10_45924120_ENST00000374391_PRSS1_chr7_142460859_ENST00000486171_length(transcript)=991nt_BP=979nt CCTGGACCGCCGCGCCGAGGCTCCCGGCGCTCGCTGCTCCCGCGGCCCGCGCCATGCCCTCCTACACGGTCACCGTGGCCACTGGCAGCC AGTGGTTCGCCGGCACTGACGACTACATCTACCTCAGCCTCGTGGGCTCGGCGGGCTGCAGCGAGAAGCACCTGCTGGACAAGCCCTTCT ACAACGACTTCGAGCGTGGCGCGGTGGATTCATACGACGTGACTGTGGACGAGGAACTGGGCGAGATCCAGCTGGTCAGAATCGAGAAGC GCAAGTACTGGCTGAATGACGACTGGTACCTGAAGTACATCACGCTGAAGACGCCCCACGGGGACTACATCGAGTTCCCCTGCTACCGCT GGATCACCGGCGATGTCGAGGTTGTCCTGAGGGATGGACGCGCAAAGTTGGCCCGAGATGACCAAATTCACATTCTCAAGCAACACCGAC GTAAAGAACTGGAAACACGGCAAAAACAATATCGATGGATGGAGTGGAACCCTGGCTTCCCCTTGAGCATCGATGCCAAATGCCACAAGG ATTTACCCCGTGATATCCAGTTTGATAGTGAAAAAGGAGTGGACTTTGTTCTGAATTACTCCAAAGCGATGGAGAACCTGTTCATCAACC GCTTCATGCACATGTTCCAGTCTTCTTGGAATGACTTCGCCGACTTTGAGAAAATCTTTGTCAAGATCAGCAACACTATTTCTGAGCGGG TCATGAATCACTGGCAGGAAGACCTGATGTTTGGCTACCAGTTCCTGAATGGCTGCAACCCTGTGTTGATCCGGCGCTGCACAGAGCTGC CCGAGAAGCTCCCGGTGACCACGGAGATGGTAGAGTGCAGCCTGGAGCGGCAGCTCAGCTTGGAGCAGGAGGTCCAGAAACAGACCCCTG CACACTCCAGTTCCTGGCCGCTCCCATCTGCTTGCTGTATAAGAACCTGGCCAACAAGATTGTCCCCATTGCCATCCAGGCCAATAGCTA >4100_4100_1_ALOX5-PRSS1_ALOX5_chr10_45924120_ENST00000374391_PRSS1_chr7_142460859_ENST00000486171_length(amino acids)=312AA_BP= MPSYTVTVATGSQWFAGTDDYIYLSLVGSAGCSEKHLLDKPFYNDFERGAVDSYDVTVDEELGEIQLVRIEKRKYWLNDDWYLKYITLKT PHGDYIEFPCYRWITGDVEVVLRDGRAKLARDDQIHILKQHRRKELETRQKQYRWMEWNPGFPLSIDAKCHKDLPRDIQFDSEKGVDFVL NYSKAMENLFINRFMHMFQSSWNDFADFEKIFVKISNTISERVMNHWQEDLMFGYQFLNGCNPVLIRRCTELPEKLPVTTEMVECSLERQ -------------------------------------------------------------- >4100_4100_2_ALOX5-PRSS1_ALOX5_chr10_45924120_ENST00000542434_PRSS1_chr7_142460859_ENST00000486171_length(transcript)=1005nt_BP=993nt GCTAGATGCGGACACCTGGACCGCCGCGCCGAGGCTCCCGGCGCTCGCTGCTCCCGCGGCCCGCGCCATGCCCTCCTACACGGTCACCGT GGCCACTGGCAGCCAGTGGTTCGCCGGCACTGACGACTACATCTACCTCAGCCTCGTGGGCTCGGCGGGCTGCAGCGAGAAGCACCTGCT GGACAAGCCCTTCTACAACGACTTCGAGCGTGGCGCGGTGGATTCATACGACGTGACTGTGGACGAGGAACTGGGCGAGATCCAGCTGGT CAGAATCGAGAAGCGCAAGTACTGGCTGAATGACGACTGGTACCTGAAGTACATCACGCTGAAGACGCCCCACGGGGACTACATCGAGTT CCCCTGCTACCGCTGGATCACCGGCGATGTCGAGGTTGTCCTGAGGGATGGACGCGCAAAGTTGGCCCGAGATGACCAAATTCACATTCT CAAGCAACACCGACGTAAAGAACTGGAAACACGGCAAAAACAATATCGATGGATGGAGTGGAACCCTGGCTTCCCCTTGAGCATCGATGC CAAATGCCACAAGGATTTACCCCGTGATATCCAGTTTGATAGTGAAAAAGGAGTGGACTTTGTTCTGAATTACTCCAAAGCGATGGAGAA CCTGTTCATCAACCGCTTCATGCACATGTTCCAGTCTTCTTGGAATGACTTCGCCGACTTTGAGAAAATCTTTGTCAAGATCAGCAACAC TATTTCTGAGCGGGTCATGAATCACTGGCAGGAAGACCTGATGTTTGGCTACCAGTTCCTGAATGGCTGCAACCCTGTGTTGATCCGGCG CTGCACAGAGCTGCCCGAGAAGCTCCCGGTGACCACGGAGATGGTAGAGTGCAGCCTGGAGCGGCAGCTCAGCTTGGAGCAGGAGGTCCA GAAACAGACCCCTGCACACTCCAGTTCCTGGCCGCTCCCATCTGCTTGCTGTATAAGAACCTGGCCAACAAGATTGTCCCCATTGCCATC >4100_4100_2_ALOX5-PRSS1_ALOX5_chr10_45924120_ENST00000542434_PRSS1_chr7_142460859_ENST00000486171_length(amino acids)=312AA_BP= MPSYTVTVATGSQWFAGTDDYIYLSLVGSAGCSEKHLLDKPFYNDFERGAVDSYDVTVDEELGEIQLVRIEKRKYWLNDDWYLKYITLKT PHGDYIEFPCYRWITGDVEVVLRDGRAKLARDDQIHILKQHRRKELETRQKQYRWMEWNPGFPLSIDAKCHKDLPRDIQFDSEKGVDFVL NYSKAMENLFINRFMHMFQSSWNDFADFEKIFVKISNTISERVMNHWQEDLMFGYQFLNGCNPVLIRRCTELPEKLPVTTEMVECSLERQ -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for ALOX5-PRSS1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for ALOX5-PRSS1 |
![]() (DrugBank Version 5.1.8 2021-05-08) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for ALOX5-PRSS1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | ALOX5 | C0007102 | Malignant tumor of colon | 3 | CTD_human |
Hgene | ALOX5 | C0009375 | Colonic Neoplasms | 3 | CTD_human |
Hgene | ALOX5 | C0023473 | Myeloid Leukemia, Chronic | 2 | CTD_human |
Hgene | ALOX5 | C0001418 | Adenocarcinoma | 1 | CTD_human |
Hgene | ALOX5 | C0001430 | Adenoma | 1 | CTD_human |
Hgene | ALOX5 | C0003873 | Rheumatoid Arthritis | 1 | CTD_human |
Hgene | ALOX5 | C0004153 | Atherosclerosis | 1 | CTD_human |
Hgene | ALOX5 | C0007134 | Renal Cell Carcinoma | 1 | CTD_human |
Hgene | ALOX5 | C0009319 | Colitis | 1 | CTD_human |
Hgene | ALOX5 | C0009376 | Colonic Polyps | 1 | CTD_human |
Hgene | ALOX5 | C0011609 | Drug Eruptions | 1 | CTD_human |
Hgene | ALOX5 | C0020429 | Hyperalgesia | 1 | CTD_human |
Hgene | ALOX5 | C0020542 | Pulmonary Hypertension | 1 | CTD_human |
Hgene | ALOX5 | C0024623 | Malignant neoplasm of stomach | 1 | CTD_human |
Hgene | ALOX5 | C0026766 | Multiple Organ Failure | 1 | CTD_human |
Hgene | ALOX5 | C0027626 | Neoplasm Invasiveness | 1 | CTD_human |
Hgene | ALOX5 | C0027627 | Neoplasm Metastasis | 1 | CTD_human |
Hgene | ALOX5 | C0027719 | Nephrosclerosis | 1 | CTD_human |
Hgene | ALOX5 | C0033578 | Prostatic Neoplasms | 1 | CTD_human |
Hgene | ALOX5 | C0035126 | Reperfusion Injury | 1 | CTD_human |
Hgene | ALOX5 | C0038356 | Stomach Neoplasms | 1 | CTD_human |
Hgene | ALOX5 | C0042109 | Urticaria | 1 | CTD_human |
Hgene | ALOX5 | C0152013 | Adenocarcinoma of lung (disorder) | 1 | CTD_human |
Hgene | ALOX5 | C0205641 | Adenocarcinoma, Basal Cell | 1 | CTD_human |
Hgene | ALOX5 | C0205642 | Adenocarcinoma, Oxyphilic | 1 | CTD_human |
Hgene | ALOX5 | C0205643 | Carcinoma, Cribriform | 1 | CTD_human |
Hgene | ALOX5 | C0205644 | Carcinoma, Granular Cell | 1 | CTD_human |
Hgene | ALOX5 | C0205645 | Adenocarcinoma, Tubular | 1 | CTD_human |
Hgene | ALOX5 | C0205646 | Adenoma, Basal Cell | 1 | CTD_human |
Hgene | ALOX5 | C0205647 | Follicular adenoma | 1 | CTD_human |
Hgene | ALOX5 | C0205648 | Adenoma, Microcystic | 1 | CTD_human |
Hgene | ALOX5 | C0205649 | Adenoma, Monomorphic | 1 | CTD_human |
Hgene | ALOX5 | C0205650 | Papillary adenoma | 1 | CTD_human |
Hgene | ALOX5 | C0205651 | Adenoma, Trabecular | 1 | CTD_human |
Hgene | ALOX5 | C0235974 | Pancreatic carcinoma | 1 | CTD_human |
Hgene | ALOX5 | C0238281 | Middle Cerebral Artery Syndrome | 1 | CTD_human |
Hgene | ALOX5 | C0279702 | Conventional (Clear Cell) Renal Cell Carcinoma | 1 | CTD_human |
Hgene | ALOX5 | C0376358 | Malignant neoplasm of prostate | 1 | CTD_human |
Hgene | ALOX5 | C0376618 | Endotoxemia | 1 | CTD_human |
Hgene | ALOX5 | C0406537 | Morbilliform Drug Reaction | 1 | CTD_human |
Hgene | ALOX5 | C0458247 | Allodynia | 1 | CTD_human |
Hgene | ALOX5 | C0740376 | Middle Cerebral Artery Thrombosis | 1 | CTD_human |
Hgene | ALOX5 | C0740391 | Middle Cerebral Artery Occlusion | 1 | CTD_human |
Hgene | ALOX5 | C0740392 | Infarction, Middle Cerebral Artery | 1 | CTD_human |
Hgene | ALOX5 | C0751211 | Hyperalgesia, Primary | 1 | CTD_human |
Hgene | ALOX5 | C0751212 | Hyperalgesia, Secondary | 1 | CTD_human |
Hgene | ALOX5 | C0751213 | Tactile Allodynia | 1 | CTD_human |
Hgene | ALOX5 | C0751214 | Hyperalgesia, Thermal | 1 | CTD_human |
Hgene | ALOX5 | C0751845 | Middle Cerebral Artery Embolus | 1 | CTD_human |
Hgene | ALOX5 | C0751846 | Left Middle Cerebral Artery Infarction | 1 | CTD_human |
Hgene | ALOX5 | C0751847 | Embolic Infarction, Middle Cerebral Artery | 1 | CTD_human |
Hgene | ALOX5 | C0751848 | Thrombotic Infarction, Middle Cerebral Artery | 1 | CTD_human |
Hgene | ALOX5 | C0751849 | Right Middle Cerebral Artery Infarction | 1 | CTD_human |
Hgene | ALOX5 | C0919267 | ovarian neoplasm | 1 | CTD_human |
Hgene | ALOX5 | C1140680 | Malignant neoplasm of ovary | 1 | CTD_human |
Hgene | ALOX5 | C1266042 | Chromophobe Renal Cell Carcinoma | 1 | CTD_human |
Hgene | ALOX5 | C1266043 | Sarcomatoid Renal Cell Carcinoma | 1 | CTD_human |
Hgene | ALOX5 | C1266044 | Collecting Duct Carcinoma of the Kidney | 1 | CTD_human |
Hgene | ALOX5 | C1306837 | Papillary Renal Cell Carcinoma | 1 | CTD_human |
Hgene | ALOX5 | C1336708 | Testicular Germ Cell Tumor | 1 | CTD_human |
Hgene | ALOX5 | C1563937 | Atherogenesis | 1 | CTD_human |
Hgene | ALOX5 | C1708349 | Hereditary Diffuse Gastric Cancer | 1 | CTD_human |
Hgene | ALOX5 | C2936719 | Mechanical Allodynia | 1 | CTD_human |
Tgene | C0238339 | Hereditary pancreatitis | 13 | CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT | |
Tgene | C0267937 | Acute recurrent pancreatitis | 2 | ORPHANET | |
Tgene | C0030305 | Pancreatitis | 1 | CTD_human | |
Tgene | C0149521 | Pancreatitis, Chronic | 1 | CTD_human | |
Tgene | C4080064 | Autosomal Dominant Hereditary Pancreatitis | 1 | CTD_human |