|
||||||
|
 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:FUS-NBR1 (FusionGDB2 ID:HG2521TG4077) |
Fusion Gene Summary for FUS-NBR1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: FUS-NBR1 | Fusion gene ID: hg2521tg4077 | Hgene | Tgene | Gene symbol | FUS | NBR1 | Gene ID | 2521 | 4077 |
| Gene name | FUS RNA binding protein | NBR1 autophagy cargo receptor | |
| Synonyms | ALS6|ETM4|FUS1|HNRNPP2|POMP75|TLS | 1A1-3B|IAI3B|M17S2|MIG19 | |
| Cytomap | ('FUS')('NBR1') 16p11.2 | 17q21.31 | |
| Type of gene | protein-coding | protein-coding | |
| Description | RNA-binding protein FUS75 kDa DNA-pairing proteinfus-like proteinfused in sarcomafusion gene in myxoid liposarcomaheterogeneous nuclear ribonucleoprotein P2oncogene FUSoncogene TLStranslocated in liposarcoma protein | next to BRCA1 gene 1 proteinB-box proteincell migration-inducing gene 19 proteinmembrane component, chromosome 17, surface marker 2 (ovarian carcinoma antigen CA125)migration-inducing protein 19neighbor of BRCA1 gene 1 | |
| Modification date | 20200329 | 20200313 | |
| UniProtAcc | P35637 | . | |
| Ensembl transtripts involved in fusion gene | ENST00000254108, ENST00000380244, ENST00000568685, ENST00000474990, | ||
| Fusion gene scores | * DoF score | 37 X 37 X 16=21904 | 6 X 7 X 5=210 |
| # samples | 44 | 7 | |
| ** MAII score | log2(44/21904*10)=-5.63754701773324 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(7/210*10)=-1.58496250072116 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: FUS [Title/Abstract] AND NBR1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | FUS(31196500)-NBR1(41355698), # samples:1 | ||
| Anticipated loss of major functional domain due to fusion event. | FUS-NBR1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. FUS-NBR1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. FUS-NBR1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. FUS-NBR1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | FUS | GO:0006355 | regulation of transcription, DNA-templated | 26124092 |
| Hgene | FUS | GO:0006357 | regulation of transcription by RNA polymerase II | 25453086 |
| Hgene | FUS | GO:0008380 | RNA splicing | 26124092 |
| Hgene | FUS | GO:0043484 | regulation of RNA splicing | 25453086|27731383 |
| Hgene | FUS | GO:0048255 | mRNA stabilization | 27378374 |
| Hgene | FUS | GO:0051260 | protein homooligomerization | 25453086 |
| Hgene | FUS | GO:1905168 | positive regulation of double-strand break repair via homologous recombination | 10567410 |
| Tgene | NBR1 | GO:0016236 | macroautophagy | 19250911 |
| Fusion gene breakpoints across FUS (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
 |
| Fusion gene breakpoints across NBR1 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
 |
| Fusion gene information * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | Non-Cancer | TCGA-CG-5721-11A | FUS | chr16 | 31196500 | + | NBR1 | chr17 | 41355698 | + |
Top |
Fusion Gene ORF analysis for FUS-NBR1 |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-intron | ENST00000254108 | ENST00000389312 | FUS | chr16 | 31196500 | + | NBR1 | chr17 | 41355698 | + |
| 5CDS-intron | ENST00000254108 | ENST00000542611 | FUS | chr16 | 31196500 | + | NBR1 | chr17 | 41355698 | + |
| 5CDS-intron | ENST00000254108 | ENST00000589872 | FUS | chr16 | 31196500 | + | NBR1 | chr17 | 41355698 | + |
| 5CDS-intron | ENST00000254108 | ENST00000590996 | FUS | chr16 | 31196500 | + | NBR1 | chr17 | 41355698 | + |
| 5CDS-intron | ENST00000380244 | ENST00000389312 | FUS | chr16 | 31196500 | + | NBR1 | chr17 | 41355698 | + |
| 5CDS-intron | ENST00000380244 | ENST00000542611 | FUS | chr16 | 31196500 | + | NBR1 | chr17 | 41355698 | + |
| 5CDS-intron | ENST00000380244 | ENST00000589872 | FUS | chr16 | 31196500 | + | NBR1 | chr17 | 41355698 | + |
| 5CDS-intron | ENST00000380244 | ENST00000590996 | FUS | chr16 | 31196500 | + | NBR1 | chr17 | 41355698 | + |
| 5CDS-intron | ENST00000568685 | ENST00000389312 | FUS | chr16 | 31196500 | + | NBR1 | chr17 | 41355698 | + |
| 5CDS-intron | ENST00000568685 | ENST00000542611 | FUS | chr16 | 31196500 | + | NBR1 | chr17 | 41355698 | + |
| 5CDS-intron | ENST00000568685 | ENST00000589872 | FUS | chr16 | 31196500 | + | NBR1 | chr17 | 41355698 | + |
| 5CDS-intron | ENST00000568685 | ENST00000590996 | FUS | chr16 | 31196500 | + | NBR1 | chr17 | 41355698 | + |
| In-frame | ENST00000254108 | ENST00000341165 | FUS | chr16 | 31196500 | + | NBR1 | chr17 | 41355698 | + |
| In-frame | ENST00000254108 | ENST00000422280 | FUS | chr16 | 31196500 | + | NBR1 | chr17 | 41355698 | + |
| In-frame | ENST00000380244 | ENST00000341165 | FUS | chr16 | 31196500 | + | NBR1 | chr17 | 41355698 | + |
| In-frame | ENST00000380244 | ENST00000422280 | FUS | chr16 | 31196500 | + | NBR1 | chr17 | 41355698 | + |
| In-frame | ENST00000568685 | ENST00000341165 | FUS | chr16 | 31196500 | + | NBR1 | chr17 | 41355698 | + |
| In-frame | ENST00000568685 | ENST00000422280 | FUS | chr16 | 31196500 | + | NBR1 | chr17 | 41355698 | + |
| intron-3CDS | ENST00000474990 | ENST00000341165 | FUS | chr16 | 31196500 | + | NBR1 | chr17 | 41355698 | + |
| intron-3CDS | ENST00000474990 | ENST00000422280 | FUS | chr16 | 31196500 | + | NBR1 | chr17 | 41355698 | + |
| intron-intron | ENST00000474990 | ENST00000389312 | FUS | chr16 | 31196500 | + | NBR1 | chr17 | 41355698 | + |
| intron-intron | ENST00000474990 | ENST00000542611 | FUS | chr16 | 31196500 | + | NBR1 | chr17 | 41355698 | + |
| intron-intron | ENST00000474990 | ENST00000589872 | FUS | chr16 | 31196500 | + | NBR1 | chr17 | 41355698 | + |
| intron-intron | ENST00000474990 | ENST00000590996 | FUS | chr16 | 31196500 | + | NBR1 | chr17 | 41355698 | + |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000254108 | FUS | chr16 | 31196500 | + | ENST00000341165 | NBR1 | chr17 | 41355698 | + | 2764 | 869 | 27 | 1148 | 373 |
| ENST00000254108 | FUS | chr16 | 31196500 | + | ENST00000422280 | NBR1 | chr17 | 41355698 | + | 2762 | 869 | 27 | 1148 | 373 |
| ENST00000380244 | FUS | chr16 | 31196500 | + | ENST00000341165 | NBR1 | chr17 | 41355698 | + | 2732 | 837 | 52 | 1116 | 354 |
| ENST00000380244 | FUS | chr16 | 31196500 | + | ENST00000422280 | NBR1 | chr17 | 41355698 | + | 2730 | 837 | 52 | 1116 | 354 |
| ENST00000568685 | FUS | chr16 | 31196500 | + | ENST00000341165 | NBR1 | chr17 | 41355698 | + | 2723 | 828 | 40 | 1107 | 355 |
| ENST00000568685 | FUS | chr16 | 31196500 | + | ENST00000422280 | NBR1 | chr17 | 41355698 | + | 2721 | 828 | 40 | 1107 | 355 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000254108 | ENST00000341165 | FUS | chr16 | 31196500 | + | NBR1 | chr17 | 41355698 | + | 0.001368807 | 0.9986312 |
| ENST00000254108 | ENST00000422280 | FUS | chr16 | 31196500 | + | NBR1 | chr17 | 41355698 | + | 0.001385467 | 0.99861455 |
| ENST00000380244 | ENST00000341165 | FUS | chr16 | 31196500 | + | NBR1 | chr17 | 41355698 | + | 0.000347255 | 0.99965274 |
| ENST00000380244 | ENST00000422280 | FUS | chr16 | 31196500 | + | NBR1 | chr17 | 41355698 | + | 0.000349582 | 0.99965036 |
| ENST00000568685 | ENST00000341165 | FUS | chr16 | 31196500 | + | NBR1 | chr17 | 41355698 | + | 0.00130691 | 0.99869305 |
| ENST00000568685 | ENST00000422280 | FUS | chr16 | 31196500 | + | NBR1 | chr17 | 41355698 | + | 0.001321695 | 0.99867827 |
Top |
Fusion Genomic Features for FUS-NBR1 |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| FUS | chr16 | 31196500 | + | NBR1 | chr17 | 41355697 | + | 1.92E-14 | 1 |
| FUS | chr16 | 31196500 | + | NBR1 | chr17 | 41355697 | + | 1.92E-14 | 1 |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
 |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
 |
Top |
Fusion Protein Features for FUS-NBR1 |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr16:31196500/chr17:41355698) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| FUS | . |
| FUNCTION: DNA/RNA-binding protein that plays a role in various cellular processes such as transcription regulation, RNA splicing, RNA transport, DNA repair and damage response (PubMed:27731383). Binds to nascent pre-mRNAs and acts as a molecular mediator between RNA polymerase II and U1 small nuclear ribonucleoprotein thereby coupling transcription and splicing (PubMed:26124092). Binds also its own pre-mRNA and autoregulates its expression; this autoregulation mechanism is mediated by non-sense-mediated decay (PubMed:24204307). Plays a role in DNA repair mechanisms by promoting D-loop formation and homologous recombination during DNA double-strand break repair (PubMed:10567410). In neuronal cells, plays crucial roles in dendritic spine formation and stability, RNA transport, mRNA stability and synaptic homeostasis (By similarity). {ECO:0000250|UniProtKB:P56959, ECO:0000269|PubMed:10567410, ECO:0000269|PubMed:24204307, ECO:0000269|PubMed:26124092, ECO:0000269|PubMed:27731383}. | FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | FUS | chr16:31196500 | chr17:41355698 | ENST00000254108 | + | 6 | 15 | 1_165 | 254 | 527.0 | Compositional bias | Note=Gln/Gly/Ser/Tyr-rich |
| Hgene | FUS | chr16:31196500 | chr17:41355698 | ENST00000380244 | + | 6 | 15 | 1_165 | 253 | 526.0 | Compositional bias | Note=Gln/Gly/Ser/Tyr-rich |
| Tgene | NBR1 | chr16:31196500 | chr17:41355698 | ENST00000341165 | 18 | 21 | 913_957 | 873 | 967.0 | Domain | UBA | |
| Tgene | NBR1 | chr16:31196500 | chr17:41355698 | ENST00000422280 | 18 | 21 | 913_957 | 873 | 967.0 | Domain | UBA | |
| Tgene | NBR1 | chr16:31196500 | chr17:41355698 | ENST00000589872 | 18 | 21 | 913_957 | 873 | 938.0 | Domain | UBA | |
| Tgene | NBR1 | chr16:31196500 | chr17:41355698 | ENST00000590996 | 18 | 21 | 913_957 | 873 | 967.0 | Domain | UBA |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | FUS | chr16:31196500 | chr17:41355698 | ENST00000254108 | + | 6 | 15 | 166_267 | 254 | 527.0 | Compositional bias | Note=Gly-rich |
| Hgene | FUS | chr16:31196500 | chr17:41355698 | ENST00000254108 | + | 6 | 15 | 371_526 | 254 | 527.0 | Compositional bias | Note=Arg/Gly-rich |
| Hgene | FUS | chr16:31196500 | chr17:41355698 | ENST00000380244 | + | 6 | 15 | 166_267 | 253 | 526.0 | Compositional bias | Note=Gly-rich |
| Hgene | FUS | chr16:31196500 | chr17:41355698 | ENST00000380244 | + | 6 | 15 | 371_526 | 253 | 526.0 | Compositional bias | Note=Arg/Gly-rich |
| Hgene | FUS | chr16:31196500 | chr17:41355698 | ENST00000254108 | + | 6 | 15 | 285_371 | 254 | 527.0 | Domain | RRM |
| Hgene | FUS | chr16:31196500 | chr17:41355698 | ENST00000380244 | + | 6 | 15 | 285_371 | 253 | 526.0 | Domain | RRM |
| Hgene | FUS | chr16:31196500 | chr17:41355698 | ENST00000254108 | + | 6 | 15 | 422_453 | 254 | 527.0 | Zinc finger | RanBP2-type |
| Hgene | FUS | chr16:31196500 | chr17:41355698 | ENST00000380244 | + | 6 | 15 | 422_453 | 253 | 526.0 | Zinc finger | RanBP2-type |
| Tgene | NBR1 | chr16:31196500 | chr17:41355698 | ENST00000341165 | 18 | 21 | 703_714 | 873 | 967.0 | Compositional bias | Note=Poly-Glu | |
| Tgene | NBR1 | chr16:31196500 | chr17:41355698 | ENST00000422280 | 18 | 21 | 703_714 | 873 | 967.0 | Compositional bias | Note=Poly-Glu | |
| Tgene | NBR1 | chr16:31196500 | chr17:41355698 | ENST00000589872 | 18 | 21 | 703_714 | 873 | 938.0 | Compositional bias | Note=Poly-Glu | |
| Tgene | NBR1 | chr16:31196500 | chr17:41355698 | ENST00000590996 | 18 | 21 | 703_714 | 873 | 967.0 | Compositional bias | Note=Poly-Glu | |
| Tgene | NBR1 | chr16:31196500 | chr17:41355698 | ENST00000341165 | 18 | 21 | 4_85 | 873 | 967.0 | Domain | PB1 | |
| Tgene | NBR1 | chr16:31196500 | chr17:41355698 | ENST00000422280 | 18 | 21 | 4_85 | 873 | 967.0 | Domain | PB1 | |
| Tgene | NBR1 | chr16:31196500 | chr17:41355698 | ENST00000589872 | 18 | 21 | 4_85 | 873 | 938.0 | Domain | PB1 | |
| Tgene | NBR1 | chr16:31196500 | chr17:41355698 | ENST00000590996 | 18 | 21 | 4_85 | 873 | 967.0 | Domain | PB1 | |
| Tgene | NBR1 | chr16:31196500 | chr17:41355698 | ENST00000341165 | 18 | 21 | 542_636 | 873 | 967.0 | Region | Note=ATG8 family protein-binding | |
| Tgene | NBR1 | chr16:31196500 | chr17:41355698 | ENST00000341165 | 18 | 21 | 727_738 | 873 | 967.0 | Region | Note=ATG8 family protein-binding | |
| Tgene | NBR1 | chr16:31196500 | chr17:41355698 | ENST00000422280 | 18 | 21 | 542_636 | 873 | 967.0 | Region | Note=ATG8 family protein-binding | |
| Tgene | NBR1 | chr16:31196500 | chr17:41355698 | ENST00000422280 | 18 | 21 | 727_738 | 873 | 967.0 | Region | Note=ATG8 family protein-binding | |
| Tgene | NBR1 | chr16:31196500 | chr17:41355698 | ENST00000589872 | 18 | 21 | 542_636 | 873 | 938.0 | Region | Note=ATG8 family protein-binding | |
| Tgene | NBR1 | chr16:31196500 | chr17:41355698 | ENST00000589872 | 18 | 21 | 727_738 | 873 | 938.0 | Region | Note=ATG8 family protein-binding | |
| Tgene | NBR1 | chr16:31196500 | chr17:41355698 | ENST00000590996 | 18 | 21 | 542_636 | 873 | 967.0 | Region | Note=ATG8 family protein-binding | |
| Tgene | NBR1 | chr16:31196500 | chr17:41355698 | ENST00000590996 | 18 | 21 | 727_738 | 873 | 967.0 | Region | Note=ATG8 family protein-binding | |
| Tgene | NBR1 | chr16:31196500 | chr17:41355698 | ENST00000341165 | 18 | 21 | 211_257 | 873 | 967.0 | Zinc finger | ZZ-type | |
| Tgene | NBR1 | chr16:31196500 | chr17:41355698 | ENST00000422280 | 18 | 21 | 211_257 | 873 | 967.0 | Zinc finger | ZZ-type | |
| Tgene | NBR1 | chr16:31196500 | chr17:41355698 | ENST00000589872 | 18 | 21 | 211_257 | 873 | 938.0 | Zinc finger | ZZ-type | |
| Tgene | NBR1 | chr16:31196500 | chr17:41355698 | ENST00000590996 | 18 | 21 | 211_257 | 873 | 967.0 | Zinc finger | ZZ-type |
Top |
Fusion Gene Sequence for FUS-NBR1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >31814_31814_1_FUS-NBR1_FUS_chr16_31196500_ENST00000254108_NBR1_chr17_41355698_ENST00000341165_length(transcript)=2764nt_BP=869nt ACTTAAGCTTCGACGCAGGAGGCGGGGCTGCTCAGTCCTCCAGGCGTCGGTACTCAGCGGTGTTGGAACTTCGTTGCTTGCTTGCCTGTG CGCGCGTGCGCGGACATGGCCTCAAACGATTATACCCAACAAGCAACCCAAAGCTATGGGGCCTACCCCACCCAGCCCGGGCAGGGCTAT TCCCAGCAGAGCAGTCAGCCCTACGGACAGCAGAGTTACAGTGGTTATAGCCAGTCCACGGACACTTCAGGCTATGGCCAGAGCAGCTAT TCTTCTTATGGCCAGAGCCAGAACACAGGCTATGGAACTCAGTCAACTCCCCAGGGATATGGCTCGACTGGCGGCTATGGCAGTAGCCAG AGCTCCCAATCGTCTTACGGGCAGCAGTCCTCCTACCCTGGCTATGGCCAGCAGCCAGCTCCCAGCAGCACCTCGGGAAGTTACGGTAGC AGTTCTCAGAGCAGCAGCTATGGGCAGCCCCAGAGTGGGAGCTACAGCCAGCAGCCTAGCTATGGTGGACAGCAGCAAAGCTATGGACAG CAGCAAAGCTATAATCCCCCTCAGGGCTATGGACAGCAGAACCAGTACAACAGCAGCAGTGGTGGTGGAGGTGGAGGTGGAGGTGGAGGT AACTATGGCCAAGATCAATCCTCCATGAGTAGTGGTGGTGGCAGTGGTGGCGGTTATGGCAATCAAGACCAGAGTGGTGGAGGTGGCAGC GGTGGCTATGGACAGCAGGACCGTGGAGGCCGCGGCAGGGGTGGCAGTGGTGGCGGCGGCGGCGGCGGCGGTGGTGGTTACAACCGCAGC AGTGGTGGCTATGAACCCAGAGGTCGTGGAGGTGGCCGTGGAGGCAGAGGTGGCATGGGGCACCATCATGGGAGCAGCATTGCTGGAGGA CTGGTGAAGGGGGCTTTGTCTGTTGCTGCCTCTGCATACAAGGCCCTGTTTGCTGGGCCACCAGTCACTGCACAGCCAATAATTTCTGAA GATCAGACAGCAGCCCTGATGGCCCATCTCTTTGAAATGGGATTCTGTGACAGGCAGCTGAACCTACGGCTGCTGAAGAAACACAATTAC AATATCCTGCAGGTTGTGACAGAACTTCTTCAGTTAAACAACAACGACTGGTACAGCCAACGCTATTGAGGAGTGACCTTGTATTAAATA ACTGCCTGCTGCTCAGAGATGATCTTTATTCTGTCATTGGGGTATGGGATAGAAGCCCTTGCTTATTTTTAATCTGATGAATCTGTATAG AGCCCATCGTTGAGTTACCAAGACAATACCTGCTACAGTATTTTGGGGAGCAAACTAAAGACCAGAACTTAAATTTTCACTTTAGACATT GGATGAATAGTATGAAGACAGTTTTTCAGTTGATTTGGATAAAACTATTTTAGTGCATTGACAAGTGTAACTTCAACTTCATATAGAACC ATTTTTCTTTCTGCTTTTATTGAAACTGAGTATTTTTCTTTGGCTAATGTGGATTTTTTATGGGGATATCTGTTAATTTTCAGGTTTTGA AAGACATTAACCTCGGAAGTTGTTTTTAAGAATTATTCTCATAATTCTTATTCTCATAATTTCTGTAATCCACCTCAAGCTTCATAGTTA TTTGGCATTGAAATAACACCCAGAGCATGATAGAAATGTTGTTACTCTTCCTCTCTCAAGGAGAAAGTAATTTTCCTGCAATACTTAATA ATTGGCACCGTTGCTTTCTAAAGACTCCATGGTGCATTCAAGAGTATCCAACTTCAAGGGAATCTCCGCATTTCAATGAAAGGAGGAAGA GTGTGCTGATAAACCTACCAGCACCTATTGAGCAATGTCTATTATAGTAATTTTGCATACATTTTTATTTAAGGGAAAAAATATAGGTAT TGTGAAATATTTTGCTAATCTTATAGAAAAGGAAAAAATCCCGTTATTTAAAGGGAAAAGTAAATTTAACAGTTGCCTTTTTTCTTAATG TCAGGGCAGATCTTATTTTACAGTACAGTGGGGGAAATAGAAACATGTGAAAGGCAAAAGGCAGGCTCCTAAATTAATGTCAGTGAAGTT CAGGGTGGGCAAATGAGTGTGTGTGAGGTATAGGAAATGCTGATGACTTCTTTAATGCTTGAAGTCCGTTCACAGGTATCTAGCCCTAGA ATGCCTAGAACAGGAAGAGGCAGCTGGTGTTCTGCAAAACTTGGACAGGGGCAAAGTTGCTGAAAAAGTTTTGGTTTAACCCGAAGATAA GTGGAAAAGAGCTTGTCCATGAACCCAGGTTCTCACTCTGTTTACAGAAGTGTGTTGAGTACAGTTGGTGAAGGAAGAGGTAACAAAAAA TGCTAAATATTTTATCCATGAAAATGACTTCCAGAAAAGGAAGAATATGAACCCCAGACCGAAGGGGAAAAGATAGTTAATAGTATTATC TAACCTGGTTGGTATTTGTAATGAATGGTGATTTTAATTAGTCATTAGCCATAATGATGTTTATTTACAGTATAACTCCTGAATGCTACT TAAATAAACCAGGATTCAAACTGCAAGCCAGCCAGGCCGTTCATTATTTAAAACGTTTTAATCGGGGCTTCCGGGTAGAAGGTGGAGCGG CAGGGTGTAATTGGGTTGATGGGTGGGACCTGTCTTGACCATCGGAGTTTTATAATCGAGGGCCAGGAGGGCCCGGGTTGCTCTCCTGGT >31814_31814_1_FUS-NBR1_FUS_chr16_31196500_ENST00000254108_NBR1_chr17_41355698_ENST00000341165_length(amino acids)=373AA_BP=281 MLSPPGVGTQRCWNFVACLPVRACADMASNDYTQQATQSYGAYPTQPGQGYSQQSSQPYGQQSYSGYSQSTDTSGYGQSSYSSYGQSQNT GYGTQSTPQGYGSTGGYGSSQSSQSSYGQQSSYPGYGQQPAPSSTSGSYGSSSQSSSYGQPQSGSYSQQPSYGGQQQSYGQQQSYNPPQG YGQQNQYNSSSGGGGGGGGGGNYGQDQSSMSSGGGSGGGYGNQDQSGGGGSGGYGQQDRGGRGRGGSGGGGGGGGGGYNRSSGGYEPRGR GGGRGGRGGMGHHHGSSIAGGLVKGALSVAASAYKALFAGPPVTAQPIISEDQTAALMAHLFEMGFCDRQLNLRLLKKHNYNILQVVTEL -------------------------------------------------------------- >31814_31814_2_FUS-NBR1_FUS_chr16_31196500_ENST00000254108_NBR1_chr17_41355698_ENST00000422280_length(transcript)=2762nt_BP=869nt ACTTAAGCTTCGACGCAGGAGGCGGGGCTGCTCAGTCCTCCAGGCGTCGGTACTCAGCGGTGTTGGAACTTCGTTGCTTGCTTGCCTGTG CGCGCGTGCGCGGACATGGCCTCAAACGATTATACCCAACAAGCAACCCAAAGCTATGGGGCCTACCCCACCCAGCCCGGGCAGGGCTAT TCCCAGCAGAGCAGTCAGCCCTACGGACAGCAGAGTTACAGTGGTTATAGCCAGTCCACGGACACTTCAGGCTATGGCCAGAGCAGCTAT TCTTCTTATGGCCAGAGCCAGAACACAGGCTATGGAACTCAGTCAACTCCCCAGGGATATGGCTCGACTGGCGGCTATGGCAGTAGCCAG AGCTCCCAATCGTCTTACGGGCAGCAGTCCTCCTACCCTGGCTATGGCCAGCAGCCAGCTCCCAGCAGCACCTCGGGAAGTTACGGTAGC AGTTCTCAGAGCAGCAGCTATGGGCAGCCCCAGAGTGGGAGCTACAGCCAGCAGCCTAGCTATGGTGGACAGCAGCAAAGCTATGGACAG CAGCAAAGCTATAATCCCCCTCAGGGCTATGGACAGCAGAACCAGTACAACAGCAGCAGTGGTGGTGGAGGTGGAGGTGGAGGTGGAGGT AACTATGGCCAAGATCAATCCTCCATGAGTAGTGGTGGTGGCAGTGGTGGCGGTTATGGCAATCAAGACCAGAGTGGTGGAGGTGGCAGC GGTGGCTATGGACAGCAGGACCGTGGAGGCCGCGGCAGGGGTGGCAGTGGTGGCGGCGGCGGCGGCGGCGGTGGTGGTTACAACCGCAGC AGTGGTGGCTATGAACCCAGAGGTCGTGGAGGTGGCCGTGGAGGCAGAGGTGGCATGGGGCACCATCATGGGAGCAGCATTGCTGGAGGA CTGGTGAAGGGGGCTTTGTCTGTTGCTGCCTCTGCATACAAGGCCCTGTTTGCTGGGCCACCAGTCACTGCACAGCCAATAATTTCTGAA GATCAGACAGCAGCCCTGATGGCCCATCTCTTTGAAATGGGATTCTGTGACAGGCAGCTGAACCTACGGCTGCTGAAGAAACACAATTAC AATATCCTGCAGGTTGTGACAGAACTTCTTCAGTTAAACAACAACGACTGGTACAGCCAACGCTATTGAGGAGTGACCTTGTATTAAATA ACTGCCTGCTGCTCAGAGATGATCTTTATTCTGTCATTGGGGTATGGGATAGAAGCCCTTGCTTATTTTTAATCTGATGAATCTGTATAG AGCCCATCGTTGAGTTACCAAGACAATACCTGCTACAGTATTTTGGGGAGCAAACTAAAGACCAGAACTTAAATTTTCACTTTAGACATT GGATGAATAGTATGAAGACAGTTTTTCAGTTGATTTGGATAAAACTATTTTAGTGCATTGACAAGTGTAACTTCAACTTCATATAGAACC ATTTTTCTTTCTGCTTTTATTGAAACTGAGTATTTTTCTTTGGCTAATGTGGATTTTTTATGGGGATATCTGTTAATTTTCAGGTTTTGA AAGACATTAACCTCGGAAGTTGTTTTTAAGAATTATTCTCATAATTCTTATTCTCATAATTTCTGTAATCCACCTCAAGCTTCATAGTTA TTTGGCATTGAAATAACACCCAGAGCATGATAGAAATGTTGTTACTCTTCCTCTCTCAAGGAGAAAGTAATTTTCCTGCAATACTTAATA ATTGGCACCGTTGCTTTCTAAAGACTCCATGGTGCATTCAAGAGTATCCAACTTCAAGGGAATCTCCGCATTTCAATGAAAGGAGGAAGA GTGTGCTGATAAACCTACCAGCACCTATTGAGCAATGTCTATTATAGTAATTTTGCATACATTTTTATTTAAGGGAAAAAATATAGGTAT TGTGAAATATTTTGCTAATCTTATAGAAAAGGAAAAAATCCCGTTATTTAAAGGGAAAAGTAAATTTAACAGTTGCCTTTTTTCTTAATG TCAGGGCAGATCTTATTTTACAGTACAGTGGGGGAAATAGAAACATGTGAAAGGCAAAAGGCAGGCTCCTAAATTAATGTCAGTGAAGTT CAGGGTGGGCAAATGAGTGTGTGTGAGGTATAGGAAATGCTGATGACTTCTTTAATGCTTGAAGTCCGTTCACAGGTATCTAGCCCTAGA ATGCCTAGAACAGGAAGAGGCAGCTGGTGTTCTGCAAAACTTGGACAGGGGCAAAGTTGCTGAAAAAGTTTTGGTTTAACCCGAAGATAA GTGGAAAAGAGCTTGTCCATGAACCCAGGTTCTCACTCTGTTTACAGAAGTGTGTTGAGTACAGTTGGTGAAGGAAGAGGTAACAAAAAA TGCTAAATATTTTATCCATGAAAATGACTTCCAGAAAAGGAAGAATATGAACCCCAGACCGAAGGGGAAAAGATAGTTAATAGTATTATC TAACCTGGTTGGTATTTGTAATGAATGGTGATTTTAATTAGTCATTAGCCATAATGATGTTTATTTACAGTATAACTCCTGAATGCTACT TAAATAAACCAGGATTCAAACTGCAAGCCAGCCAGGCCGTTCATTATTTAAAACGTTTTAATCGGGGCTTCCGGGTAGAAGGTGGAGCGG CAGGGTGTAATTGGGTTGATGGGTGGGACCTGTCTTGACCATCGGAGTTTTATAATCGAGGGCCAGGAGGGCCCGGGTTGCTCTCCTGGT >31814_31814_2_FUS-NBR1_FUS_chr16_31196500_ENST00000254108_NBR1_chr17_41355698_ENST00000422280_length(amino acids)=373AA_BP=281 MLSPPGVGTQRCWNFVACLPVRACADMASNDYTQQATQSYGAYPTQPGQGYSQQSSQPYGQQSYSGYSQSTDTSGYGQSSYSSYGQSQNT GYGTQSTPQGYGSTGGYGSSQSSQSSYGQQSSYPGYGQQPAPSSTSGSYGSSSQSSSYGQPQSGSYSQQPSYGGQQQSYGQQQSYNPPQG YGQQNQYNSSSGGGGGGGGGGNYGQDQSSMSSGGGSGGGYGNQDQSGGGGSGGYGQQDRGGRGRGGSGGGGGGGGGGYNRSSGGYEPRGR GGGRGGRGGMGHHHGSSIAGGLVKGALSVAASAYKALFAGPPVTAQPIISEDQTAALMAHLFEMGFCDRQLNLRLLKKHNYNILQVVTEL -------------------------------------------------------------- >31814_31814_3_FUS-NBR1_FUS_chr16_31196500_ENST00000380244_NBR1_chr17_41355698_ENST00000341165_length(transcript)=2732nt_BP=837nt GCTCAGTCCTCCAGGCGTCGGTACTCAGCGGTGTTGGAACTTCGTTGCTTGCTTGCCTGTGCGCGCGTGCGCGGACATGGCCTCAAACGA TTATACCCAACAAGCAACCCAAAGCTATGGGGCCTACCCCACCCAGCCCGGGCAGGGCTATTCCCAGCAGAGCAGTCAGCCCTACGGACA GCAGAGTTACAGTGGTTATAGCCAGTCCACGGACACTTCAGGCTATGGCCAGAGCAGCTATTCTTCTTATGGCCAGAGCCAGAACAGCTA TGGAACTCAGTCAACTCCCCAGGGATATGGCTCGACTGGCGGCTATGGCAGTAGCCAGAGCTCCCAATCGTCTTACGGGCAGCAGTCCTC CTACCCTGGCTATGGCCAGCAGCCAGCTCCCAGCAGCACCTCGGGAAGTTACGGTAGCAGTTCTCAGAGCAGCAGCTATGGGCAGCCCCA GAGTGGGAGCTACAGCCAGCAGCCTAGCTATGGTGGACAGCAGCAAAGCTATGGACAGCAGCAAAGCTATAATCCCCCTCAGGGCTATGG ACAGCAGAACCAGTACAACAGCAGCAGTGGTGGTGGAGGTGGAGGTGGAGGTGGAGGTAACTATGGCCAAGATCAATCCTCCATGAGTAG TGGTGGTGGCAGTGGTGGCGGTTATGGCAATCAAGACCAGAGTGGTGGAGGTGGCAGCGGTGGCTATGGACAGCAGGACCGTGGAGGCCG CGGCAGGGGTGGCAGTGGTGGCGGCGGCGGCGGCGGCGGTGGTGGTTACAACCGCAGCAGTGGTGGCTATGAACCCAGAGGTCGTGGAGG TGGCCGTGGAGGCAGAGGTGGCATGGGGCACCATCATGGGAGCAGCATTGCTGGAGGACTGGTGAAGGGGGCTTTGTCTGTTGCTGCCTC TGCATACAAGGCCCTGTTTGCTGGGCCACCAGTCACTGCACAGCCAATAATTTCTGAAGATCAGACAGCAGCCCTGATGGCCCATCTCTT TGAAATGGGATTCTGTGACAGGCAGCTGAACCTACGGCTGCTGAAGAAACACAATTACAATATCCTGCAGGTTGTGACAGAACTTCTTCA GTTAAACAACAACGACTGGTACAGCCAACGCTATTGAGGAGTGACCTTGTATTAAATAACTGCCTGCTGCTCAGAGATGATCTTTATTCT GTCATTGGGGTATGGGATAGAAGCCCTTGCTTATTTTTAATCTGATGAATCTGTATAGAGCCCATCGTTGAGTTACCAAGACAATACCTG CTACAGTATTTTGGGGAGCAAACTAAAGACCAGAACTTAAATTTTCACTTTAGACATTGGATGAATAGTATGAAGACAGTTTTTCAGTTG ATTTGGATAAAACTATTTTAGTGCATTGACAAGTGTAACTTCAACTTCATATAGAACCATTTTTCTTTCTGCTTTTATTGAAACTGAGTA TTTTTCTTTGGCTAATGTGGATTTTTTATGGGGATATCTGTTAATTTTCAGGTTTTGAAAGACATTAACCTCGGAAGTTGTTTTTAAGAA TTATTCTCATAATTCTTATTCTCATAATTTCTGTAATCCACCTCAAGCTTCATAGTTATTTGGCATTGAAATAACACCCAGAGCATGATA GAAATGTTGTTACTCTTCCTCTCTCAAGGAGAAAGTAATTTTCCTGCAATACTTAATAATTGGCACCGTTGCTTTCTAAAGACTCCATGG TGCATTCAAGAGTATCCAACTTCAAGGGAATCTCCGCATTTCAATGAAAGGAGGAAGAGTGTGCTGATAAACCTACCAGCACCTATTGAG CAATGTCTATTATAGTAATTTTGCATACATTTTTATTTAAGGGAAAAAATATAGGTATTGTGAAATATTTTGCTAATCTTATAGAAAAGG AAAAAATCCCGTTATTTAAAGGGAAAAGTAAATTTAACAGTTGCCTTTTTTCTTAATGTCAGGGCAGATCTTATTTTACAGTACAGTGGG GGAAATAGAAACATGTGAAAGGCAAAAGGCAGGCTCCTAAATTAATGTCAGTGAAGTTCAGGGTGGGCAAATGAGTGTGTGTGAGGTATA GGAAATGCTGATGACTTCTTTAATGCTTGAAGTCCGTTCACAGGTATCTAGCCCTAGAATGCCTAGAACAGGAAGAGGCAGCTGGTGTTC TGCAAAACTTGGACAGGGGCAAAGTTGCTGAAAAAGTTTTGGTTTAACCCGAAGATAAGTGGAAAAGAGCTTGTCCATGAACCCAGGTTC TCACTCTGTTTACAGAAGTGTGTTGAGTACAGTTGGTGAAGGAAGAGGTAACAAAAAATGCTAAATATTTTATCCATGAAAATGACTTCC AGAAAAGGAAGAATATGAACCCCAGACCGAAGGGGAAAAGATAGTTAATAGTATTATCTAACCTGGTTGGTATTTGTAATGAATGGTGAT TTTAATTAGTCATTAGCCATAATGATGTTTATTTACAGTATAACTCCTGAATGCTACTTAAATAAACCAGGATTCAAACTGCAAGCCAGC CAGGCCGTTCATTATTTAAAACGTTTTAATCGGGGCTTCCGGGTAGAAGGTGGAGCGGCAGGGTGTAATTGGGTTGATGGGTGGGACCTG TCTTGACCATCGGAGTTTTATAATCGAGGGCCAGGAGGGCCCGGGTTGCTCTCCTGGTTATGTATGTACTTGTACATAACCACCTAAAGA >31814_31814_3_FUS-NBR1_FUS_chr16_31196500_ENST00000380244_NBR1_chr17_41355698_ENST00000341165_length(amino acids)=354AA_BP=262 MPVRACADMASNDYTQQATQSYGAYPTQPGQGYSQQSSQPYGQQSYSGYSQSTDTSGYGQSSYSSYGQSQNSYGTQSTPQGYGSTGGYGS SQSSQSSYGQQSSYPGYGQQPAPSSTSGSYGSSSQSSSYGQPQSGSYSQQPSYGGQQQSYGQQQSYNPPQGYGQQNQYNSSSGGGGGGGG GGNYGQDQSSMSSGGGSGGGYGNQDQSGGGGSGGYGQQDRGGRGRGGSGGGGGGGGGGYNRSSGGYEPRGRGGGRGGRGGMGHHHGSSIA -------------------------------------------------------------- >31814_31814_4_FUS-NBR1_FUS_chr16_31196500_ENST00000380244_NBR1_chr17_41355698_ENST00000422280_length(transcript)=2730nt_BP=837nt GCTCAGTCCTCCAGGCGTCGGTACTCAGCGGTGTTGGAACTTCGTTGCTTGCTTGCCTGTGCGCGCGTGCGCGGACATGGCCTCAAACGA TTATACCCAACAAGCAACCCAAAGCTATGGGGCCTACCCCACCCAGCCCGGGCAGGGCTATTCCCAGCAGAGCAGTCAGCCCTACGGACA GCAGAGTTACAGTGGTTATAGCCAGTCCACGGACACTTCAGGCTATGGCCAGAGCAGCTATTCTTCTTATGGCCAGAGCCAGAACAGCTA TGGAACTCAGTCAACTCCCCAGGGATATGGCTCGACTGGCGGCTATGGCAGTAGCCAGAGCTCCCAATCGTCTTACGGGCAGCAGTCCTC CTACCCTGGCTATGGCCAGCAGCCAGCTCCCAGCAGCACCTCGGGAAGTTACGGTAGCAGTTCTCAGAGCAGCAGCTATGGGCAGCCCCA GAGTGGGAGCTACAGCCAGCAGCCTAGCTATGGTGGACAGCAGCAAAGCTATGGACAGCAGCAAAGCTATAATCCCCCTCAGGGCTATGG ACAGCAGAACCAGTACAACAGCAGCAGTGGTGGTGGAGGTGGAGGTGGAGGTGGAGGTAACTATGGCCAAGATCAATCCTCCATGAGTAG TGGTGGTGGCAGTGGTGGCGGTTATGGCAATCAAGACCAGAGTGGTGGAGGTGGCAGCGGTGGCTATGGACAGCAGGACCGTGGAGGCCG CGGCAGGGGTGGCAGTGGTGGCGGCGGCGGCGGCGGCGGTGGTGGTTACAACCGCAGCAGTGGTGGCTATGAACCCAGAGGTCGTGGAGG TGGCCGTGGAGGCAGAGGTGGCATGGGGCACCATCATGGGAGCAGCATTGCTGGAGGACTGGTGAAGGGGGCTTTGTCTGTTGCTGCCTC TGCATACAAGGCCCTGTTTGCTGGGCCACCAGTCACTGCACAGCCAATAATTTCTGAAGATCAGACAGCAGCCCTGATGGCCCATCTCTT TGAAATGGGATTCTGTGACAGGCAGCTGAACCTACGGCTGCTGAAGAAACACAATTACAATATCCTGCAGGTTGTGACAGAACTTCTTCA GTTAAACAACAACGACTGGTACAGCCAACGCTATTGAGGAGTGACCTTGTATTAAATAACTGCCTGCTGCTCAGAGATGATCTTTATTCT GTCATTGGGGTATGGGATAGAAGCCCTTGCTTATTTTTAATCTGATGAATCTGTATAGAGCCCATCGTTGAGTTACCAAGACAATACCTG CTACAGTATTTTGGGGAGCAAACTAAAGACCAGAACTTAAATTTTCACTTTAGACATTGGATGAATAGTATGAAGACAGTTTTTCAGTTG ATTTGGATAAAACTATTTTAGTGCATTGACAAGTGTAACTTCAACTTCATATAGAACCATTTTTCTTTCTGCTTTTATTGAAACTGAGTA TTTTTCTTTGGCTAATGTGGATTTTTTATGGGGATATCTGTTAATTTTCAGGTTTTGAAAGACATTAACCTCGGAAGTTGTTTTTAAGAA TTATTCTCATAATTCTTATTCTCATAATTTCTGTAATCCACCTCAAGCTTCATAGTTATTTGGCATTGAAATAACACCCAGAGCATGATA GAAATGTTGTTACTCTTCCTCTCTCAAGGAGAAAGTAATTTTCCTGCAATACTTAATAATTGGCACCGTTGCTTTCTAAAGACTCCATGG TGCATTCAAGAGTATCCAACTTCAAGGGAATCTCCGCATTTCAATGAAAGGAGGAAGAGTGTGCTGATAAACCTACCAGCACCTATTGAG CAATGTCTATTATAGTAATTTTGCATACATTTTTATTTAAGGGAAAAAATATAGGTATTGTGAAATATTTTGCTAATCTTATAGAAAAGG AAAAAATCCCGTTATTTAAAGGGAAAAGTAAATTTAACAGTTGCCTTTTTTCTTAATGTCAGGGCAGATCTTATTTTACAGTACAGTGGG GGAAATAGAAACATGTGAAAGGCAAAAGGCAGGCTCCTAAATTAATGTCAGTGAAGTTCAGGGTGGGCAAATGAGTGTGTGTGAGGTATA GGAAATGCTGATGACTTCTTTAATGCTTGAAGTCCGTTCACAGGTATCTAGCCCTAGAATGCCTAGAACAGGAAGAGGCAGCTGGTGTTC TGCAAAACTTGGACAGGGGCAAAGTTGCTGAAAAAGTTTTGGTTTAACCCGAAGATAAGTGGAAAAGAGCTTGTCCATGAACCCAGGTTC TCACTCTGTTTACAGAAGTGTGTTGAGTACAGTTGGTGAAGGAAGAGGTAACAAAAAATGCTAAATATTTTATCCATGAAAATGACTTCC AGAAAAGGAAGAATATGAACCCCAGACCGAAGGGGAAAAGATAGTTAATAGTATTATCTAACCTGGTTGGTATTTGTAATGAATGGTGAT TTTAATTAGTCATTAGCCATAATGATGTTTATTTACAGTATAACTCCTGAATGCTACTTAAATAAACCAGGATTCAAACTGCAAGCCAGC CAGGCCGTTCATTATTTAAAACGTTTTAATCGGGGCTTCCGGGTAGAAGGTGGAGCGGCAGGGTGTAATTGGGTTGATGGGTGGGACCTG TCTTGACCATCGGAGTTTTATAATCGAGGGCCAGGAGGGCCCGGGTTGCTCTCCTGGTTATGTATGTACTTGTACATAACCACCTAAAGA >31814_31814_4_FUS-NBR1_FUS_chr16_31196500_ENST00000380244_NBR1_chr17_41355698_ENST00000422280_length(amino acids)=354AA_BP=262 MPVRACADMASNDYTQQATQSYGAYPTQPGQGYSQQSSQPYGQQSYSGYSQSTDTSGYGQSSYSSYGQSQNSYGTQSTPQGYGSTGGYGS SQSSQSSYGQQSSYPGYGQQPAPSSTSGSYGSSSQSSSYGQPQSGSYSQQPSYGGQQQSYGQQQSYNPPQGYGQQNQYNSSSGGGGGGGG GGNYGQDQSSMSSGGGSGGGYGNQDQSGGGGSGGYGQQDRGGRGRGGSGGGGGGGGGGYNRSSGGYEPRGRGGGRGGRGGMGHHHGSSIA -------------------------------------------------------------- >31814_31814_5_FUS-NBR1_FUS_chr16_31196500_ENST00000568685_NBR1_chr17_41355698_ENST00000341165_length(transcript)=2723nt_BP=828nt AGGCGTCGGTACTCAGCGGTGTTGGAACTTCGTTGCTTGCTTGCCTGTGCGCGCGTGCGCGGACATGGCCTCAAACGATTATACCCAACA AGCAACCCAAAGCTATGGGGCCTACCCCACCCAGCCCGGGCAGGGCTATTCCCAGCAGAGCAGTCAGCCCTACGGACAGCAGAGTTACAG TGGTTATAGCCAGTCCACGGACACTTCAGGCTATGGCCAGAGCAGCTATTCTTCTTATGGCCAGAGCCAGAACACAGGCTATGGAACTCA GTCAACTCCCCAGGGATATGGCTCGACTGGCGGCTATGGCAGTAGCCAGAGCTCCCAATCGTCTTACGGGCAGCAGTCCTCCTACCCTGG CTATGGCCAGCAGCCAGCTCCCAGCAGCACCTCGGGAAGTTACGGTAGCAGTTCTCAGAGCAGCAGCTATGGGCAGCCCCAGAGTGGGAG CTACAGCCAGCAGCCTAGCTATGGTGGACAGCAGCAAAGCTATGGACAGCAGCAAAGCTATAATCCCCCTCAGGGCTATGGACAGCAGAA CCAGTACAACAGCAGCAGTGGTGGTGGAGGTGGAGGTGGAGGTGGAGGTAACTATGGCCAAGATCAATCCTCCATGAGTAGTGGTGGTGG CAGTGGTGGCGGTTATGGCAATCAAGACCAGAGTGGTGGAGGTGGCAGCGGTGGCTATGGACAGCAGGACCGTGGAGGCCGCGGCAGGGG TGGCAGTGGTGGCGGCGGCGGCGGCGGCGGTGGTGGTTACAACCGCAGCAGTGGTGGCTATGAACCCAGAGGTCGTGGAGGTGGCCGTGG AGGCAGAGGTGGCATGGGGCACCATCATGGGAGCAGCATTGCTGGAGGACTGGTGAAGGGGGCTTTGTCTGTTGCTGCCTCTGCATACAA GGCCCTGTTTGCTGGGCCACCAGTCACTGCACAGCCAATAATTTCTGAAGATCAGACAGCAGCCCTGATGGCCCATCTCTTTGAAATGGG ATTCTGTGACAGGCAGCTGAACCTACGGCTGCTGAAGAAACACAATTACAATATCCTGCAGGTTGTGACAGAACTTCTTCAGTTAAACAA CAACGACTGGTACAGCCAACGCTATTGAGGAGTGACCTTGTATTAAATAACTGCCTGCTGCTCAGAGATGATCTTTATTCTGTCATTGGG GTATGGGATAGAAGCCCTTGCTTATTTTTAATCTGATGAATCTGTATAGAGCCCATCGTTGAGTTACCAAGACAATACCTGCTACAGTAT TTTGGGGAGCAAACTAAAGACCAGAACTTAAATTTTCACTTTAGACATTGGATGAATAGTATGAAGACAGTTTTTCAGTTGATTTGGATA AAACTATTTTAGTGCATTGACAAGTGTAACTTCAACTTCATATAGAACCATTTTTCTTTCTGCTTTTATTGAAACTGAGTATTTTTCTTT GGCTAATGTGGATTTTTTATGGGGATATCTGTTAATTTTCAGGTTTTGAAAGACATTAACCTCGGAAGTTGTTTTTAAGAATTATTCTCA TAATTCTTATTCTCATAATTTCTGTAATCCACCTCAAGCTTCATAGTTATTTGGCATTGAAATAACACCCAGAGCATGATAGAAATGTTG TTACTCTTCCTCTCTCAAGGAGAAAGTAATTTTCCTGCAATACTTAATAATTGGCACCGTTGCTTTCTAAAGACTCCATGGTGCATTCAA GAGTATCCAACTTCAAGGGAATCTCCGCATTTCAATGAAAGGAGGAAGAGTGTGCTGATAAACCTACCAGCACCTATTGAGCAATGTCTA TTATAGTAATTTTGCATACATTTTTATTTAAGGGAAAAAATATAGGTATTGTGAAATATTTTGCTAATCTTATAGAAAAGGAAAAAATCC CGTTATTTAAAGGGAAAAGTAAATTTAACAGTTGCCTTTTTTCTTAATGTCAGGGCAGATCTTATTTTACAGTACAGTGGGGGAAATAGA AACATGTGAAAGGCAAAAGGCAGGCTCCTAAATTAATGTCAGTGAAGTTCAGGGTGGGCAAATGAGTGTGTGTGAGGTATAGGAAATGCT GATGACTTCTTTAATGCTTGAAGTCCGTTCACAGGTATCTAGCCCTAGAATGCCTAGAACAGGAAGAGGCAGCTGGTGTTCTGCAAAACT TGGACAGGGGCAAAGTTGCTGAAAAAGTTTTGGTTTAACCCGAAGATAAGTGGAAAAGAGCTTGTCCATGAACCCAGGTTCTCACTCTGT TTACAGAAGTGTGTTGAGTACAGTTGGTGAAGGAAGAGGTAACAAAAAATGCTAAATATTTTATCCATGAAAATGACTTCCAGAAAAGGA AGAATATGAACCCCAGACCGAAGGGGAAAAGATAGTTAATAGTATTATCTAACCTGGTTGGTATTTGTAATGAATGGTGATTTTAATTAG TCATTAGCCATAATGATGTTTATTTACAGTATAACTCCTGAATGCTACTTAAATAAACCAGGATTCAAACTGCAAGCCAGCCAGGCCGTT CATTATTTAAAACGTTTTAATCGGGGCTTCCGGGTAGAAGGTGGAGCGGCAGGGTGTAATTGGGTTGATGGGTGGGACCTGTCTTGACCA TCGGAGTTTTATAATCGAGGGCCAGGAGGGCCCGGGTTGCTCTCCTGGTTATGTATGTACTTGTACATAACCACCTAAAGAATGGTGAAA >31814_31814_5_FUS-NBR1_FUS_chr16_31196500_ENST00000568685_NBR1_chr17_41355698_ENST00000341165_length(amino acids)=355AA_BP=263 MPVRACADMASNDYTQQATQSYGAYPTQPGQGYSQQSSQPYGQQSYSGYSQSTDTSGYGQSSYSSYGQSQNTGYGTQSTPQGYGSTGGYG SSQSSQSSYGQQSSYPGYGQQPAPSSTSGSYGSSSQSSSYGQPQSGSYSQQPSYGGQQQSYGQQQSYNPPQGYGQQNQYNSSSGGGGGGG GGGNYGQDQSSMSSGGGSGGGYGNQDQSGGGGSGGYGQQDRGGRGRGGSGGGGGGGGGGYNRSSGGYEPRGRGGGRGGRGGMGHHHGSSI -------------------------------------------------------------- >31814_31814_6_FUS-NBR1_FUS_chr16_31196500_ENST00000568685_NBR1_chr17_41355698_ENST00000422280_length(transcript)=2721nt_BP=828nt AGGCGTCGGTACTCAGCGGTGTTGGAACTTCGTTGCTTGCTTGCCTGTGCGCGCGTGCGCGGACATGGCCTCAAACGATTATACCCAACA AGCAACCCAAAGCTATGGGGCCTACCCCACCCAGCCCGGGCAGGGCTATTCCCAGCAGAGCAGTCAGCCCTACGGACAGCAGAGTTACAG TGGTTATAGCCAGTCCACGGACACTTCAGGCTATGGCCAGAGCAGCTATTCTTCTTATGGCCAGAGCCAGAACACAGGCTATGGAACTCA GTCAACTCCCCAGGGATATGGCTCGACTGGCGGCTATGGCAGTAGCCAGAGCTCCCAATCGTCTTACGGGCAGCAGTCCTCCTACCCTGG CTATGGCCAGCAGCCAGCTCCCAGCAGCACCTCGGGAAGTTACGGTAGCAGTTCTCAGAGCAGCAGCTATGGGCAGCCCCAGAGTGGGAG CTACAGCCAGCAGCCTAGCTATGGTGGACAGCAGCAAAGCTATGGACAGCAGCAAAGCTATAATCCCCCTCAGGGCTATGGACAGCAGAA CCAGTACAACAGCAGCAGTGGTGGTGGAGGTGGAGGTGGAGGTGGAGGTAACTATGGCCAAGATCAATCCTCCATGAGTAGTGGTGGTGG CAGTGGTGGCGGTTATGGCAATCAAGACCAGAGTGGTGGAGGTGGCAGCGGTGGCTATGGACAGCAGGACCGTGGAGGCCGCGGCAGGGG TGGCAGTGGTGGCGGCGGCGGCGGCGGCGGTGGTGGTTACAACCGCAGCAGTGGTGGCTATGAACCCAGAGGTCGTGGAGGTGGCCGTGG AGGCAGAGGTGGCATGGGGCACCATCATGGGAGCAGCATTGCTGGAGGACTGGTGAAGGGGGCTTTGTCTGTTGCTGCCTCTGCATACAA GGCCCTGTTTGCTGGGCCACCAGTCACTGCACAGCCAATAATTTCTGAAGATCAGACAGCAGCCCTGATGGCCCATCTCTTTGAAATGGG ATTCTGTGACAGGCAGCTGAACCTACGGCTGCTGAAGAAACACAATTACAATATCCTGCAGGTTGTGACAGAACTTCTTCAGTTAAACAA CAACGACTGGTACAGCCAACGCTATTGAGGAGTGACCTTGTATTAAATAACTGCCTGCTGCTCAGAGATGATCTTTATTCTGTCATTGGG GTATGGGATAGAAGCCCTTGCTTATTTTTAATCTGATGAATCTGTATAGAGCCCATCGTTGAGTTACCAAGACAATACCTGCTACAGTAT TTTGGGGAGCAAACTAAAGACCAGAACTTAAATTTTCACTTTAGACATTGGATGAATAGTATGAAGACAGTTTTTCAGTTGATTTGGATA AAACTATTTTAGTGCATTGACAAGTGTAACTTCAACTTCATATAGAACCATTTTTCTTTCTGCTTTTATTGAAACTGAGTATTTTTCTTT GGCTAATGTGGATTTTTTATGGGGATATCTGTTAATTTTCAGGTTTTGAAAGACATTAACCTCGGAAGTTGTTTTTAAGAATTATTCTCA TAATTCTTATTCTCATAATTTCTGTAATCCACCTCAAGCTTCATAGTTATTTGGCATTGAAATAACACCCAGAGCATGATAGAAATGTTG TTACTCTTCCTCTCTCAAGGAGAAAGTAATTTTCCTGCAATACTTAATAATTGGCACCGTTGCTTTCTAAAGACTCCATGGTGCATTCAA GAGTATCCAACTTCAAGGGAATCTCCGCATTTCAATGAAAGGAGGAAGAGTGTGCTGATAAACCTACCAGCACCTATTGAGCAATGTCTA TTATAGTAATTTTGCATACATTTTTATTTAAGGGAAAAAATATAGGTATTGTGAAATATTTTGCTAATCTTATAGAAAAGGAAAAAATCC CGTTATTTAAAGGGAAAAGTAAATTTAACAGTTGCCTTTTTTCTTAATGTCAGGGCAGATCTTATTTTACAGTACAGTGGGGGAAATAGA AACATGTGAAAGGCAAAAGGCAGGCTCCTAAATTAATGTCAGTGAAGTTCAGGGTGGGCAAATGAGTGTGTGTGAGGTATAGGAAATGCT GATGACTTCTTTAATGCTTGAAGTCCGTTCACAGGTATCTAGCCCTAGAATGCCTAGAACAGGAAGAGGCAGCTGGTGTTCTGCAAAACT TGGACAGGGGCAAAGTTGCTGAAAAAGTTTTGGTTTAACCCGAAGATAAGTGGAAAAGAGCTTGTCCATGAACCCAGGTTCTCACTCTGT TTACAGAAGTGTGTTGAGTACAGTTGGTGAAGGAAGAGGTAACAAAAAATGCTAAATATTTTATCCATGAAAATGACTTCCAGAAAAGGA AGAATATGAACCCCAGACCGAAGGGGAAAAGATAGTTAATAGTATTATCTAACCTGGTTGGTATTTGTAATGAATGGTGATTTTAATTAG TCATTAGCCATAATGATGTTTATTTACAGTATAACTCCTGAATGCTACTTAAATAAACCAGGATTCAAACTGCAAGCCAGCCAGGCCGTT CATTATTTAAAACGTTTTAATCGGGGCTTCCGGGTAGAAGGTGGAGCGGCAGGGTGTAATTGGGTTGATGGGTGGGACCTGTCTTGACCA TCGGAGTTTTATAATCGAGGGCCAGGAGGGCCCGGGTTGCTCTCCTGGTTATGTATGTACTTGTACATAACCACCTAAAGAATGGTGAAA >31814_31814_6_FUS-NBR1_FUS_chr16_31196500_ENST00000568685_NBR1_chr17_41355698_ENST00000422280_length(amino acids)=355AA_BP=263 MPVRACADMASNDYTQQATQSYGAYPTQPGQGYSQQSSQPYGQQSYSGYSQSTDTSGYGQSSYSSYGQSQNTGYGTQSTPQGYGSTGGYG SSQSSQSSYGQQSSYPGYGQQPAPSSTSGSYGSSSQSSSYGQPQSGSYSQQPSYGGQQQSYGQQQSYNPPQGYGQQNQYNSSSGGGGGGG GGGNYGQDQSSMSSGGGSGGGYGNQDQSGGGGSGGYGQQDRGGRGRGGSGGGGGGGGGGYNRSSGGYEPRGRGGGRGGRGGMGHHHGSSI -------------------------------------------------------------- |
Top |
Fusion Gene PPI Analysis for FUS-NBR1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
Related Drugs for FUS-NBR1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
Related Diseases for FUS-NBR1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | FUS | C1842675 | AMYOTROPHIC LATERAL SCLEROSIS 6 (disorder) | 5 | UNIPROT |
| Hgene | FUS | C3468114 | Juvenile amyotrophic lateral sclerosis | 5 | ORPHANET |
| Hgene | FUS | C0002736 | Amyotrophic Lateral Sclerosis | 2 | CTD_human;ORPHANET |
| Hgene | FUS | C0206634 | Liposarcoma, Myxoid | 2 | CTD_human;ORPHANET |
| Hgene | FUS | C0393554 | Amyotrophic Lateral Sclerosis With Dementia | 1 | CTD_human |
| Hgene | FUS | C0497327 | Dementia | 1 | GENOMICS_ENGLAND |
| Hgene | FUS | C0543859 | Amyotrophic Lateral Sclerosis, Guam Form | 1 | CTD_human |
| Hgene | FUS | C3539195 | TREMOR, HEREDITARY ESSENTIAL, 4 | 1 | CTD_human;UNIPROT |
| Hgene | FUS | C3888102 | Frontotemporal Dementia With Motor Neuron Disease | 1 | ORPHANET |
Copyright 2021-Present -The University of Texas Health Science Center at Houston (UTHealth)
Web File Viewing | Emergency Information |Campus Carry|Site Policies