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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:FUS-ATF1 (FusionGDB2 ID:HG2521TG466)

Fusion Gene Summary for FUS-ATF1

check button Fusion gene summary
Fusion gene informationFusion gene name: FUS-ATF1
Fusion gene ID: hg2521tg466
HgeneTgene
Gene symbol

FUS

ATF1

Gene ID

2521

466

Gene nameFUS RNA binding proteinactivating transcription factor 1
SynonymsALS6|ETM4|FUS1|HNRNPP2|POMP75|TLSEWS-ATF1|FUS/ATF-1|TREB36
Cytomap('FUS')('ATF1')

16p11.2

12q13.12

Type of geneprotein-codingprotein-coding
DescriptionRNA-binding protein FUS75 kDa DNA-pairing proteinfus-like proteinfused in sarcomafusion gene in myxoid liposarcomaheterogeneous nuclear ribonucleoprotein P2oncogene FUSoncogene TLStranslocated in liposarcoma proteincyclic AMP-dependent transcription factor ATF-1cAMP-dependent transcription factor ATF-1
Modification date2020032920200315
UniProtAcc

P35637

P18846

Ensembl transtripts involved in fusion geneENST00000254108, ENST00000380244, 
ENST00000568685, ENST00000474990, 
ENST00000254108, ENST00000380244, 
ENST00000568685, ENST00000474990, 
Fusion gene scores* DoF score37 X 37 X 16=2190410 X 16 X 7=1120
# samples 4416
** MAII scorelog2(44/21904*10)=-5.63754701773324
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(16/1120*10)=-2.8073549220576
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: FUS [Title/Abstract] AND ATF1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointFUS(31195717)-ATF1(51207791), # samples:2
Anticipated loss of major functional domain due to fusion event.FUS-ATF1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
FUS-ATF1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
FUS-ATF1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
FUS-ATF1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneFUS

GO:0006355

regulation of transcription, DNA-templated

26124092

HgeneFUS

GO:0006357

regulation of transcription by RNA polymerase II

25453086

HgeneFUS

GO:0008380

RNA splicing

26124092

HgeneFUS

GO:0043484

regulation of RNA splicing

25453086|27731383

HgeneFUS

GO:0048255

mRNA stabilization

27378374

HgeneFUS

GO:0051260

protein homooligomerization

25453086

HgeneFUS

GO:1905168

positive regulation of double-strand break repair via homologous recombination

10567410

TgeneATF1

GO:0045944

positive regulation of transcription by RNA polymerase II

1655749


check buttonFusion gene breakpoints across FUS (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across ATF1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4refractory anemia;angiomatoid malignant fibrous histiocytomaAJ295163FUSchr16

31195717

ATF1chr12

51207791
ChimerKB3..FUSchr16

31195323

+ATF1chr12

51157788

+
ChimerKB3..FUSchr16

31195705

+ATF1chr12

51207792

+
ChimerKB3..FUSchr16

31195705

+ATF1chr5

37835929

-
ChimerKB3..FUSchr16

31195717

+ATF1chr12

51207791

+


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Fusion Gene ORF analysis for FUS-ATF1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000254108ENST00000539132FUSchr16

31195717

ATF1chr12

51207791

5CDS-5UTRENST00000254108ENST00000539132FUSchr16

31195705

+ATF1chr12

51207792

+
5CDS-5UTRENST00000254108ENST00000539132FUSchr16

31195717

+ATF1chr12

51207791

+
5CDS-5UTRENST00000380244ENST00000539132FUSchr16

31195717

ATF1chr12

51207791

5CDS-5UTRENST00000380244ENST00000539132FUSchr16

31195705

+ATF1chr12

51207792

+
5CDS-5UTRENST00000380244ENST00000539132FUSchr16

31195717

+ATF1chr12

51207791

+
5CDS-5UTRENST00000568685ENST00000539132FUSchr16

31195717

ATF1chr12

51207791

5CDS-5UTRENST00000568685ENST00000539132FUSchr16

31195705

+ATF1chr12

51207792

+
5CDS-5UTRENST00000568685ENST00000539132FUSchr16

31195717

+ATF1chr12

51207791

+
5CDS-intronENST00000254108ENST00000262053FUSchr16

31195323

+ATF1chr12

51157788

+
5CDS-intronENST00000254108ENST00000262053FUSchr16

31195705

+ATF1chr5

37835929

-
5CDS-intronENST00000254108ENST00000539132FUSchr16

31195323

+ATF1chr12

51157788

+
5CDS-intronENST00000254108ENST00000539132FUSchr16

31195705

+ATF1chr5

37835929

-
5CDS-intronENST00000380244ENST00000262053FUSchr16

31195323

+ATF1chr12

51157788

+
5CDS-intronENST00000380244ENST00000262053FUSchr16

31195705

+ATF1chr5

37835929

-
5CDS-intronENST00000380244ENST00000539132FUSchr16

31195323

+ATF1chr12

51157788

+
5CDS-intronENST00000380244ENST00000539132FUSchr16

31195705

+ATF1chr5

37835929

-
5CDS-intronENST00000568685ENST00000262053FUSchr16

31195323

+ATF1chr12

51157788

+
5CDS-intronENST00000568685ENST00000262053FUSchr16

31195705

+ATF1chr5

37835929

-
5CDS-intronENST00000568685ENST00000539132FUSchr16

31195323

+ATF1chr12

51157788

+
5CDS-intronENST00000568685ENST00000539132FUSchr16

31195705

+ATF1chr5

37835929

-
In-frameENST00000254108ENST00000262053FUSchr16

31195717

ATF1chr12

51207791

In-frameENST00000254108ENST00000262053FUSchr16

31195705

+ATF1chr12

51207792

+
In-frameENST00000254108ENST00000262053FUSchr16

31195717

+ATF1chr12

51207791

+
In-frameENST00000380244ENST00000262053FUSchr16

31195717

ATF1chr12

51207791

In-frameENST00000380244ENST00000262053FUSchr16

31195705

+ATF1chr12

51207792

+
In-frameENST00000380244ENST00000262053FUSchr16

31195717

+ATF1chr12

51207791

+
In-frameENST00000568685ENST00000262053FUSchr16

31195717

ATF1chr12

51207791

In-frameENST00000568685ENST00000262053FUSchr16

31195705

+ATF1chr12

51207792

+
In-frameENST00000568685ENST00000262053FUSchr16

31195717

+ATF1chr12

51207791

+
intron-3CDSENST00000474990ENST00000262053FUSchr16

31195717

ATF1chr12

51207791

intron-3CDSENST00000474990ENST00000262053FUSchr16

31195705

+ATF1chr12

51207792

+
intron-3CDSENST00000474990ENST00000262053FUSchr16

31195717

+ATF1chr12

51207791

+
intron-5UTRENST00000474990ENST00000539132FUSchr16

31195717

ATF1chr12

51207791

intron-5UTRENST00000474990ENST00000539132FUSchr16

31195705

+ATF1chr12

51207792

+
intron-5UTRENST00000474990ENST00000539132FUSchr16

31195717

+ATF1chr12

51207791

+
intron-intronENST00000474990ENST00000262053FUSchr16

31195323

+ATF1chr12

51157788

+
intron-intronENST00000474990ENST00000262053FUSchr16

31195705

+ATF1chr5

37835929

-
intron-intronENST00000474990ENST00000539132FUSchr16

31195323

+ATF1chr12

51157788

+
intron-intronENST00000474990ENST00000539132FUSchr16

31195705

+ATF1chr5

37835929

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000254108FUSchr1631195705+ENST00000262053ATF1chr1251207792+228345273939288
ENST00000380244FUSchr1631195705+ENST00000262053ATF1chr1251207792+225142044907287
ENST00000568685FUSchr1631195705+ENST00000262053ATF1chr1251207792+224241132898288
ENST00000254108FUSchr1631195717+ENST00000262053ATF1chr1251207791+2459628271115362
ENST00000380244FUSchr1631195717+ENST00000262053ATF1chr1251207791+2427596521083343
ENST00000568685FUSchr1631195717+ENST00000262053ATF1chr1251207791+2418587401074344
ENST00000254108FUSchr1631195717ENST00000262053ATF1chr12512077912459628271115362
ENST00000380244FUSchr1631195717ENST00000262053ATF1chr12512077912427596521083343
ENST00000568685FUSchr1631195717ENST00000262053ATF1chr12512077912418587401074344

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000254108ENST00000262053FUSchr1631195717ATF1chr12512077910.0005676120.9994324
ENST00000380244ENST00000262053FUSchr1631195717ATF1chr12512077910.0001216270.9998784
ENST00000568685ENST00000262053FUSchr1631195717ATF1chr12512077910.000547540.9994524

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Fusion Genomic Features for FUS-ATF1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
FUSchr1631195717+ATF1chr1251207792+0.0141049970.98589504
FUSchr1631195717+ATF1chr1251207792+0.0141049970.98589504

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for FUS-ATF1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr16:31195717/chr12:51207791)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FUS

P35637

ATF1

P18846

FUNCTION: DNA/RNA-binding protein that plays a role in various cellular processes such as transcription regulation, RNA splicing, RNA transport, DNA repair and damage response (PubMed:27731383). Binds to nascent pre-mRNAs and acts as a molecular mediator between RNA polymerase II and U1 small nuclear ribonucleoprotein thereby coupling transcription and splicing (PubMed:26124092). Binds also its own pre-mRNA and autoregulates its expression; this autoregulation mechanism is mediated by non-sense-mediated decay (PubMed:24204307). Plays a role in DNA repair mechanisms by promoting D-loop formation and homologous recombination during DNA double-strand break repair (PubMed:10567410). In neuronal cells, plays crucial roles in dendritic spine formation and stability, RNA transport, mRNA stability and synaptic homeostasis (By similarity). {ECO:0000250|UniProtKB:P56959, ECO:0000269|PubMed:10567410, ECO:0000269|PubMed:24204307, ECO:0000269|PubMed:26124092, ECO:0000269|PubMed:27731383}.FUNCTION: This protein binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Binds to the Tax-responsive element (TRE) of HTLV-I. Mediates PKA-induced stimulation of CRE-reporter genes. Represses the expression of FTH1 and other antioxidant detoxification genes. Triggers cell proliferation and transformation. {ECO:0000269|PubMed:18794154, ECO:0000269|PubMed:20980392}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneFUSchr16:31195717chr12:51207791ENST00000254108+5151_165174527.0Compositional biasNote=Gln/Gly/Ser/Tyr-rich
HgeneFUSchr16:31195717chr12:51207791ENST00000380244+5151_165173526.0Compositional biasNote=Gln/Gly/Ser/Tyr-rich
TgeneATF1chr16:31195717chr12:51207791ENST0000026205337213_271109272.0DomainbZIP
TgeneATF1chr16:31195717chr12:51207791ENST0000026205337215_239109272.0RegionBasic motif
TgeneATF1chr16:31195717chr12:51207791ENST0000026205337241_262109272.0RegionLeucine-zipper

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneFUSchr16:31195717chr12:51207791ENST00000254108+515166_267174527.0Compositional biasNote=Gly-rich
HgeneFUSchr16:31195717chr12:51207791ENST00000254108+515371_526174527.0Compositional biasNote=Arg/Gly-rich
HgeneFUSchr16:31195717chr12:51207791ENST00000380244+515166_267173526.0Compositional biasNote=Gly-rich
HgeneFUSchr16:31195717chr12:51207791ENST00000380244+515371_526173526.0Compositional biasNote=Arg/Gly-rich
HgeneFUSchr16:31195717chr12:51207791ENST00000254108+515285_371174527.0DomainRRM
HgeneFUSchr16:31195717chr12:51207791ENST00000380244+515285_371173526.0DomainRRM
HgeneFUSchr16:31195717chr12:51207791ENST00000254108+515422_453174527.0Zinc fingerRanBP2-type
HgeneFUSchr16:31195717chr12:51207791ENST00000380244+515422_453173526.0Zinc fingerRanBP2-type
TgeneATF1chr16:31195717chr12:51207791ENST000002620533731_90109272.0DomainKID


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Fusion Gene Sequence for FUS-ATF1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>31790_31790_1_FUS-ATF1_FUS_chr16_31195705_ENST00000254108_ATF1_chr12_51207792_ENST00000262053_length(transcript)=2283nt_BP=452nt
ACTTAAGCTTCGACGCAGGAGGCGGGGCTGCTCAGTCCTCCAGGCGTCGGTACTCAGCGGTGTTGGAACTTCGTTGCTTGCTTGCCTGTG
CGCGCGTGCGCGGACATGGCCTCAAACGATTATACCCAACAAGCAACCCAAAGCTATGGGGCCTACCCCACCCAGCCCGGGCAGGGCTAT
TCCCAGCAGAGCAGTCAGCCCTACGGACAGCAGAGTTACAGTGGTTATAGCCAGTCCACGGACACTTCAGGCTATGGCCAGAGCAGCTAT
TCTTCTTATGGCCAGAGCCAGAACACAGGCTATGGAACTCAGTCAACTCCCCAGGGATATGGCTCGACTGGCGGCTATGGCAGTAGCCAG
AGCTCCCAATCGTCTTACGGGCAGCAGTCCTCCTACCCTGGCTATGGCCAGCAGCCAGCTCCCAGCAGCACCTCGGGAAGGTGGAGGTGG
AGTTGCCATTGCCCCAAATGGAGCCTTACAGTTGGCAAGTCCAGGCACAGATGGAGTACAGGGACTTCAGACATTAACCATGACAAATTC
AGGCAGTACTCAGCAAGGTACAACTATTCTTCAGTATGCACAGACCTCTGATGGACAGCAGATACTTGTGCCCAGCAATCAGGTGGTCGT
ACAAACTGCATCAGGAGATATGCAAACATATCAGATCCGAACTACACCTTCAGCTACTTCTCTGCCACAAACTGTGGTGATGACATCTCC
TGTGACTCTCACCTCTCAGACAACTAAGACAGATGACCCCCAATTGAAAAGAGAAATAAGGTTAATGAAAAACAGAGAAGCTGCTCGAGA
ATGTCGCAGAAAGAAGAAAGAATATGTGAAATGCCTGGAAAACCGAGTTGCAGTCCTGGAAAATCAAAATAAAACTCTAATAGAAGAGTT
AAAAACTTTGAAGGATCTTTATTCCAATAAAAGTGTTTGATTCCTAAGAAAGAAAATATTTTTGTGGACATGCATAAAAATTAAATGGAT
TTCCTAGTGGAGTTTTATAAATTAAAAGGTCAAAACTGAAGCTTTTTATTTAGGCTTTTCCAAATCAAGGATAAATATCTTACGCACGAT
ATCTAGTGACAGAGGAGAAAGTGGAAAATGACCTCAAGGAAGCTACGGGCACAACTGGAAGCTTTGTAGAAATTAAACATATTCAAGGAG
CAAGAAATGAACTTTCAGCAGTCTAAATTTTCTAAATAACCAATAGTTGCCAATCTAAAATGGCAGAGAAGATGAAATTTGATAAACTGA
ATTTTTTTTAAAAATCCATTTACCCTACAGGTTTGCATTTGTTTGCTGAAATTTACCTTTTTTTAGTTATATATATGTGTGTGTGTGTGT
GTAATTTCTGCCAATAAATTCTAAATTACAAAGGTAAGAGAAAACCTAGTACATTACTAAATATATAAAGTATATGTTCTGATTATGTAT
ACTTGTTCTAGTGTCAAGTCTTTTTAAGTGGGTTTTTAAAAGTTTGTTATTGGACTTGAATGGATTTTTGAGACTAGGTTAATTATTTTT
GAGGTCTTATCCTAAAAGGCATCTAAGGTACATGAATGGAGTATGGTGATTTTATAACATTTTTTATCAGAATGGAAAAAGAACTGTTTA
AAAGTTTGATACTTTTAAATAGTTGGTTTTTTTGCTTACTCTGGTAATGATTTTCTACAAATACATAATAAATTGTTTTTTTGAGTCTAT
ATTCTGTATGCAGTTGAATATCCATTACTTATTCTGCTGTGCTTTAATAGAATGGAATGTTTACAGGCCCTTAAAATATTATTTTTAAAA
AACCTTCTGAAGATACATACCAAAGTTTTTCCAAGAAGATTTTATAATCAATTTAATAATGTAAGGTTTATCAGATTCTATAATAGTATA
GTTATTAAGGCAATTTTATGTTAGAGACTATTTTGTAATGTAGTGAGTGGTACCTTTATAAGAAAAGTGACTGCCAATATATTTTTATAG
CTGATCTTTATAAATTCTAATGTTGAGTTTTTAATGATTATTTTAAATGTTTATATAGTTTAGTAAAATTTGCATCTCAAAGTATCATTT
TTATATTATGGGACGTTTTCAGATTGGCTAATATTTGCATTGTAAATTTTGTATGCAGTTTATCTAAAATTCAAAAATACTGTCAGTACA
CCAGCGTTTAACATCTATATTCCAATTTGTATACAGTTTAAAATTGTACTGCAAAACTATTGTGTGCTCTTACACAGTATGCATCATATT

>31790_31790_1_FUS-ATF1_FUS_chr16_31195705_ENST00000254108_ATF1_chr12_51207792_ENST00000262053_length(amino acids)=288AA_BP=126
MLACLCARARTWPQTIIPNKQPKAMGPTPPSPGRAIPSRAVSPTDSRVTVVIASPRTLQAMARAAILLMARARTQAMELSQLPRDMARLA
AMAVARAPNRLTGSSPPTLAMASSQLPAAPREGGGGVAIAPNGALQLASPGTDGVQGLQTLTMTNSGSTQQGTTILQYAQTSDGQQILVP
SNQVVVQTASGDMQTYQIRTTPSATSLPQTVVMTSPVTLTSQTTKTDDPQLKREIRLMKNREAARECRRKKKEYVKCLENRVAVLENQNK

--------------------------------------------------------------
>31790_31790_2_FUS-ATF1_FUS_chr16_31195705_ENST00000380244_ATF1_chr12_51207792_ENST00000262053_length(transcript)=2251nt_BP=420nt
GCTCAGTCCTCCAGGCGTCGGTACTCAGCGGTGTTGGAACTTCGTTGCTTGCTTGCCTGTGCGCGCGTGCGCGGACATGGCCTCAAACGA
TTATACCCAACAAGCAACCCAAAGCTATGGGGCCTACCCCACCCAGCCCGGGCAGGGCTATTCCCAGCAGAGCAGTCAGCCCTACGGACA
GCAGAGTTACAGTGGTTATAGCCAGTCCACGGACACTTCAGGCTATGGCCAGAGCAGCTATTCTTCTTATGGCCAGAGCCAGAACAGCTA
TGGAACTCAGTCAACTCCCCAGGGATATGGCTCGACTGGCGGCTATGGCAGTAGCCAGAGCTCCCAATCGTCTTACGGGCAGCAGTCCTC
CTACCCTGGCTATGGCCAGCAGCCAGCTCCCAGCAGCACCTCGGGAAGGTGGAGGTGGAGTTGCCATTGCCCCAAATGGAGCCTTACAGT
TGGCAAGTCCAGGCACAGATGGAGTACAGGGACTTCAGACATTAACCATGACAAATTCAGGCAGTACTCAGCAAGGTACAACTATTCTTC
AGTATGCACAGACCTCTGATGGACAGCAGATACTTGTGCCCAGCAATCAGGTGGTCGTACAAACTGCATCAGGAGATATGCAAACATATC
AGATCCGAACTACACCTTCAGCTACTTCTCTGCCACAAACTGTGGTGATGACATCTCCTGTGACTCTCACCTCTCAGACAACTAAGACAG
ATGACCCCCAATTGAAAAGAGAAATAAGGTTAATGAAAAACAGAGAAGCTGCTCGAGAATGTCGCAGAAAGAAGAAAGAATATGTGAAAT
GCCTGGAAAACCGAGTTGCAGTCCTGGAAAATCAAAATAAAACTCTAATAGAAGAGTTAAAAACTTTGAAGGATCTTTATTCCAATAAAA
GTGTTTGATTCCTAAGAAAGAAAATATTTTTGTGGACATGCATAAAAATTAAATGGATTTCCTAGTGGAGTTTTATAAATTAAAAGGTCA
AAACTGAAGCTTTTTATTTAGGCTTTTCCAAATCAAGGATAAATATCTTACGCACGATATCTAGTGACAGAGGAGAAAGTGGAAAATGAC
CTCAAGGAAGCTACGGGCACAACTGGAAGCTTTGTAGAAATTAAACATATTCAAGGAGCAAGAAATGAACTTTCAGCAGTCTAAATTTTC
TAAATAACCAATAGTTGCCAATCTAAAATGGCAGAGAAGATGAAATTTGATAAACTGAATTTTTTTTAAAAATCCATTTACCCTACAGGT
TTGCATTTGTTTGCTGAAATTTACCTTTTTTTAGTTATATATATGTGTGTGTGTGTGTGTAATTTCTGCCAATAAATTCTAAATTACAAA
GGTAAGAGAAAACCTAGTACATTACTAAATATATAAAGTATATGTTCTGATTATGTATACTTGTTCTAGTGTCAAGTCTTTTTAAGTGGG
TTTTTAAAAGTTTGTTATTGGACTTGAATGGATTTTTGAGACTAGGTTAATTATTTTTGAGGTCTTATCCTAAAAGGCATCTAAGGTACA
TGAATGGAGTATGGTGATTTTATAACATTTTTTATCAGAATGGAAAAAGAACTGTTTAAAAGTTTGATACTTTTAAATAGTTGGTTTTTT
TGCTTACTCTGGTAATGATTTTCTACAAATACATAATAAATTGTTTTTTTGAGTCTATATTCTGTATGCAGTTGAATATCCATTACTTAT
TCTGCTGTGCTTTAATAGAATGGAATGTTTACAGGCCCTTAAAATATTATTTTTAAAAAACCTTCTGAAGATACATACCAAAGTTTTTCC
AAGAAGATTTTATAATCAATTTAATAATGTAAGGTTTATCAGATTCTATAATAGTATAGTTATTAAGGCAATTTTATGTTAGAGACTATT
TTGTAATGTAGTGAGTGGTACCTTTATAAGAAAAGTGACTGCCAATATATTTTTATAGCTGATCTTTATAAATTCTAATGTTGAGTTTTT
AATGATTATTTTAAATGTTTATATAGTTTAGTAAAATTTGCATCTCAAAGTATCATTTTTATATTATGGGACGTTTTCAGATTGGCTAAT
ATTTGCATTGTAAATTTTGTATGCAGTTTATCTAAAATTCAAAAATACTGTCAGTACACCAGCGTTTAACATCTATATTCCAATTTGTAT
ACAGTTTAAAATTGTACTGCAAAACTATTGTGTGCTCTTACACAGTATGCATCATATTGTTGTCTGTGAAATTAAAGGACATTTGATAGT

>31790_31790_2_FUS-ATF1_FUS_chr16_31195705_ENST00000380244_ATF1_chr12_51207792_ENST00000262053_length(amino acids)=287AA_BP=125
MLACLCARARTWPQTIIPNKQPKAMGPTPPSPGRAIPSRAVSPTDSRVTVVIASPRTLQAMARAAILLMARARTAMELSQLPRDMARLAA
MAVARAPNRLTGSSPPTLAMASSQLPAAPREGGGGVAIAPNGALQLASPGTDGVQGLQTLTMTNSGSTQQGTTILQYAQTSDGQQILVPS
NQVVVQTASGDMQTYQIRTTPSATSLPQTVVMTSPVTLTSQTTKTDDPQLKREIRLMKNREAARECRRKKKEYVKCLENRVAVLENQNKT

--------------------------------------------------------------
>31790_31790_3_FUS-ATF1_FUS_chr16_31195705_ENST00000568685_ATF1_chr12_51207792_ENST00000262053_length(transcript)=2242nt_BP=411nt
AGGCGTCGGTACTCAGCGGTGTTGGAACTTCGTTGCTTGCTTGCCTGTGCGCGCGTGCGCGGACATGGCCTCAAACGATTATACCCAACA
AGCAACCCAAAGCTATGGGGCCTACCCCACCCAGCCCGGGCAGGGCTATTCCCAGCAGAGCAGTCAGCCCTACGGACAGCAGAGTTACAG
TGGTTATAGCCAGTCCACGGACACTTCAGGCTATGGCCAGAGCAGCTATTCTTCTTATGGCCAGAGCCAGAACACAGGCTATGGAACTCA
GTCAACTCCCCAGGGATATGGCTCGACTGGCGGCTATGGCAGTAGCCAGAGCTCCCAATCGTCTTACGGGCAGCAGTCCTCCTACCCTGG
CTATGGCCAGCAGCCAGCTCCCAGCAGCACCTCGGGAAGGTGGAGGTGGAGTTGCCATTGCCCCAAATGGAGCCTTACAGTTGGCAAGTC
CAGGCACAGATGGAGTACAGGGACTTCAGACATTAACCATGACAAATTCAGGCAGTACTCAGCAAGGTACAACTATTCTTCAGTATGCAC
AGACCTCTGATGGACAGCAGATACTTGTGCCCAGCAATCAGGTGGTCGTACAAACTGCATCAGGAGATATGCAAACATATCAGATCCGAA
CTACACCTTCAGCTACTTCTCTGCCACAAACTGTGGTGATGACATCTCCTGTGACTCTCACCTCTCAGACAACTAAGACAGATGACCCCC
AATTGAAAAGAGAAATAAGGTTAATGAAAAACAGAGAAGCTGCTCGAGAATGTCGCAGAAAGAAGAAAGAATATGTGAAATGCCTGGAAA
ACCGAGTTGCAGTCCTGGAAAATCAAAATAAAACTCTAATAGAAGAGTTAAAAACTTTGAAGGATCTTTATTCCAATAAAAGTGTTTGAT
TCCTAAGAAAGAAAATATTTTTGTGGACATGCATAAAAATTAAATGGATTTCCTAGTGGAGTTTTATAAATTAAAAGGTCAAAACTGAAG
CTTTTTATTTAGGCTTTTCCAAATCAAGGATAAATATCTTACGCACGATATCTAGTGACAGAGGAGAAAGTGGAAAATGACCTCAAGGAA
GCTACGGGCACAACTGGAAGCTTTGTAGAAATTAAACATATTCAAGGAGCAAGAAATGAACTTTCAGCAGTCTAAATTTTCTAAATAACC
AATAGTTGCCAATCTAAAATGGCAGAGAAGATGAAATTTGATAAACTGAATTTTTTTTAAAAATCCATTTACCCTACAGGTTTGCATTTG
TTTGCTGAAATTTACCTTTTTTTAGTTATATATATGTGTGTGTGTGTGTGTAATTTCTGCCAATAAATTCTAAATTACAAAGGTAAGAGA
AAACCTAGTACATTACTAAATATATAAAGTATATGTTCTGATTATGTATACTTGTTCTAGTGTCAAGTCTTTTTAAGTGGGTTTTTAAAA
GTTTGTTATTGGACTTGAATGGATTTTTGAGACTAGGTTAATTATTTTTGAGGTCTTATCCTAAAAGGCATCTAAGGTACATGAATGGAG
TATGGTGATTTTATAACATTTTTTATCAGAATGGAAAAAGAACTGTTTAAAAGTTTGATACTTTTAAATAGTTGGTTTTTTTGCTTACTC
TGGTAATGATTTTCTACAAATACATAATAAATTGTTTTTTTGAGTCTATATTCTGTATGCAGTTGAATATCCATTACTTATTCTGCTGTG
CTTTAATAGAATGGAATGTTTACAGGCCCTTAAAATATTATTTTTAAAAAACCTTCTGAAGATACATACCAAAGTTTTTCCAAGAAGATT
TTATAATCAATTTAATAATGTAAGGTTTATCAGATTCTATAATAGTATAGTTATTAAGGCAATTTTATGTTAGAGACTATTTTGTAATGT
AGTGAGTGGTACCTTTATAAGAAAAGTGACTGCCAATATATTTTTATAGCTGATCTTTATAAATTCTAATGTTGAGTTTTTAATGATTAT
TTTAAATGTTTATATAGTTTAGTAAAATTTGCATCTCAAAGTATCATTTTTATATTATGGGACGTTTTCAGATTGGCTAATATTTGCATT
GTAAATTTTGTATGCAGTTTATCTAAAATTCAAAAATACTGTCAGTACACCAGCGTTTAACATCTATATTCCAATTTGTATACAGTTTAA

>31790_31790_3_FUS-ATF1_FUS_chr16_31195705_ENST00000568685_ATF1_chr12_51207792_ENST00000262053_length(amino acids)=288AA_BP=126
MLACLCARARTWPQTIIPNKQPKAMGPTPPSPGRAIPSRAVSPTDSRVTVVIASPRTLQAMARAAILLMARARTQAMELSQLPRDMARLA
AMAVARAPNRLTGSSPPTLAMASSQLPAAPREGGGGVAIAPNGALQLASPGTDGVQGLQTLTMTNSGSTQQGTTILQYAQTSDGQQILVP
SNQVVVQTASGDMQTYQIRTTPSATSLPQTVVMTSPVTLTSQTTKTDDPQLKREIRLMKNREAARECRRKKKEYVKCLENRVAVLENQNK

--------------------------------------------------------------
>31790_31790_4_FUS-ATF1_FUS_chr16_31195717_ENST00000254108_ATF1_chr12_51207791_ENST00000262053_length(transcript)=2459nt_BP=628nt
ACTTAAGCTTCGACGCAGGAGGCGGGGCTGCTCAGTCCTCCAGGCGTCGGTACTCAGCGGTGTTGGAACTTCGTTGCTTGCTTGCCTGTG
CGCGCGTGCGCGGACATGGCCTCAAACGATTATACCCAACAAGCAACCCAAAGCTATGGGGCCTACCCCACCCAGCCCGGGCAGGGCTAT
TCCCAGCAGAGCAGTCAGCCCTACGGACAGCAGAGTTACAGTGGTTATAGCCAGTCCACGGACACTTCAGGCTATGGCCAGAGCAGCTAT
TCTTCTTATGGCCAGAGCCAGAACACAGGCTATGGAACTCAGTCAACTCCCCAGGGATATGGCTCGACTGGCGGCTATGGCAGTAGCCAG
AGCTCCCAATCGTCTTACGGGCAGCAGTCCTCCTACCCTGGCTATGGCCAGCAGCCAGCTCCCAGCAGCACCTCGGGAAGTTACGGTAGC
AGTTCTCAGAGCAGCAGCTATGGGCAGCCCCAGAGTGGGAGCTACAGCCAGCAGCCTAGCTATGGTGGACAGCAGCAAAGCTATGGACAG
CAGCAAAGCTATAATCCCCCTCAGGGCTATGGACAGCAGAACCAGTACAACAGCAGCAGTGGTGGTGGAGGTGGAGGTGGAGGTGGAGTT
GCCATTGCCCCAAATGGAGCCTTACAGTTGGCAAGTCCAGGCACAGATGGAGTACAGGGACTTCAGACATTAACCATGACAAATTCAGGC
AGTACTCAGCAAGGTACAACTATTCTTCAGTATGCACAGACCTCTGATGGACAGCAGATACTTGTGCCCAGCAATCAGGTGGTCGTACAA
ACTGCATCAGGAGATATGCAAACATATCAGATCCGAACTACACCTTCAGCTACTTCTCTGCCACAAACTGTGGTGATGACATCTCCTGTG
ACTCTCACCTCTCAGACAACTAAGACAGATGACCCCCAATTGAAAAGAGAAATAAGGTTAATGAAAAACAGAGAAGCTGCTCGAGAATGT
CGCAGAAAGAAGAAAGAATATGTGAAATGCCTGGAAAACCGAGTTGCAGTCCTGGAAAATCAAAATAAAACTCTAATAGAAGAGTTAAAA
ACTTTGAAGGATCTTTATTCCAATAAAAGTGTTTGATTCCTAAGAAAGAAAATATTTTTGTGGACATGCATAAAAATTAAATGGATTTCC
TAGTGGAGTTTTATAAATTAAAAGGTCAAAACTGAAGCTTTTTATTTAGGCTTTTCCAAATCAAGGATAAATATCTTACGCACGATATCT
AGTGACAGAGGAGAAAGTGGAAAATGACCTCAAGGAAGCTACGGGCACAACTGGAAGCTTTGTAGAAATTAAACATATTCAAGGAGCAAG
AAATGAACTTTCAGCAGTCTAAATTTTCTAAATAACCAATAGTTGCCAATCTAAAATGGCAGAGAAGATGAAATTTGATAAACTGAATTT
TTTTTAAAAATCCATTTACCCTACAGGTTTGCATTTGTTTGCTGAAATTTACCTTTTTTTAGTTATATATATGTGTGTGTGTGTGTGTAA
TTTCTGCCAATAAATTCTAAATTACAAAGGTAAGAGAAAACCTAGTACATTACTAAATATATAAAGTATATGTTCTGATTATGTATACTT
GTTCTAGTGTCAAGTCTTTTTAAGTGGGTTTTTAAAAGTTTGTTATTGGACTTGAATGGATTTTTGAGACTAGGTTAATTATTTTTGAGG
TCTTATCCTAAAAGGCATCTAAGGTACATGAATGGAGTATGGTGATTTTATAACATTTTTTATCAGAATGGAAAAAGAACTGTTTAAAAG
TTTGATACTTTTAAATAGTTGGTTTTTTTGCTTACTCTGGTAATGATTTTCTACAAATACATAATAAATTGTTTTTTTGAGTCTATATTC
TGTATGCAGTTGAATATCCATTACTTATTCTGCTGTGCTTTAATAGAATGGAATGTTTACAGGCCCTTAAAATATTATTTTTAAAAAACC
TTCTGAAGATACATACCAAAGTTTTTCCAAGAAGATTTTATAATCAATTTAATAATGTAAGGTTTATCAGATTCTATAATAGTATAGTTA
TTAAGGCAATTTTATGTTAGAGACTATTTTGTAATGTAGTGAGTGGTACCTTTATAAGAAAAGTGACTGCCAATATATTTTTATAGCTGA
TCTTTATAAATTCTAATGTTGAGTTTTTAATGATTATTTTAAATGTTTATATAGTTTAGTAAAATTTGCATCTCAAAGTATCATTTTTAT
ATTATGGGACGTTTTCAGATTGGCTAATATTTGCATTGTAAATTTTGTATGCAGTTTATCTAAAATTCAAAAATACTGTCAGTACACCAG
CGTTTAACATCTATATTCCAATTTGTATACAGTTTAAAATTGTACTGCAAAACTATTGTGTGCTCTTACACAGTATGCATCATATTGTTG

>31790_31790_4_FUS-ATF1_FUS_chr16_31195717_ENST00000254108_ATF1_chr12_51207791_ENST00000262053_length(amino acids)=362AA_BP=200
MLSPPGVGTQRCWNFVACLPVRACADMASNDYTQQATQSYGAYPTQPGQGYSQQSSQPYGQQSYSGYSQSTDTSGYGQSSYSSYGQSQNT
GYGTQSTPQGYGSTGGYGSSQSSQSSYGQQSSYPGYGQQPAPSSTSGSYGSSSQSSSYGQPQSGSYSQQPSYGGQQQSYGQQQSYNPPQG
YGQQNQYNSSSGGGGGGGGGVAIAPNGALQLASPGTDGVQGLQTLTMTNSGSTQQGTTILQYAQTSDGQQILVPSNQVVVQTASGDMQTY
QIRTTPSATSLPQTVVMTSPVTLTSQTTKTDDPQLKREIRLMKNREAARECRRKKKEYVKCLENRVAVLENQNKTLIEELKTLKDLYSNK

--------------------------------------------------------------
>31790_31790_5_FUS-ATF1_FUS_chr16_31195717_ENST00000380244_ATF1_chr12_51207791_ENST00000262053_length(transcript)=2427nt_BP=596nt
GCTCAGTCCTCCAGGCGTCGGTACTCAGCGGTGTTGGAACTTCGTTGCTTGCTTGCCTGTGCGCGCGTGCGCGGACATGGCCTCAAACGA
TTATACCCAACAAGCAACCCAAAGCTATGGGGCCTACCCCACCCAGCCCGGGCAGGGCTATTCCCAGCAGAGCAGTCAGCCCTACGGACA
GCAGAGTTACAGTGGTTATAGCCAGTCCACGGACACTTCAGGCTATGGCCAGAGCAGCTATTCTTCTTATGGCCAGAGCCAGAACAGCTA
TGGAACTCAGTCAACTCCCCAGGGATATGGCTCGACTGGCGGCTATGGCAGTAGCCAGAGCTCCCAATCGTCTTACGGGCAGCAGTCCTC
CTACCCTGGCTATGGCCAGCAGCCAGCTCCCAGCAGCACCTCGGGAAGTTACGGTAGCAGTTCTCAGAGCAGCAGCTATGGGCAGCCCCA
GAGTGGGAGCTACAGCCAGCAGCCTAGCTATGGTGGACAGCAGCAAAGCTATGGACAGCAGCAAAGCTATAATCCCCCTCAGGGCTATGG
ACAGCAGAACCAGTACAACAGCAGCAGTGGTGGTGGAGGTGGAGGTGGAGGTGGAGTTGCCATTGCCCCAAATGGAGCCTTACAGTTGGC
AAGTCCAGGCACAGATGGAGTACAGGGACTTCAGACATTAACCATGACAAATTCAGGCAGTACTCAGCAAGGTACAACTATTCTTCAGTA
TGCACAGACCTCTGATGGACAGCAGATACTTGTGCCCAGCAATCAGGTGGTCGTACAAACTGCATCAGGAGATATGCAAACATATCAGAT
CCGAACTACACCTTCAGCTACTTCTCTGCCACAAACTGTGGTGATGACATCTCCTGTGACTCTCACCTCTCAGACAACTAAGACAGATGA
CCCCCAATTGAAAAGAGAAATAAGGTTAATGAAAAACAGAGAAGCTGCTCGAGAATGTCGCAGAAAGAAGAAAGAATATGTGAAATGCCT
GGAAAACCGAGTTGCAGTCCTGGAAAATCAAAATAAAACTCTAATAGAAGAGTTAAAAACTTTGAAGGATCTTTATTCCAATAAAAGTGT
TTGATTCCTAAGAAAGAAAATATTTTTGTGGACATGCATAAAAATTAAATGGATTTCCTAGTGGAGTTTTATAAATTAAAAGGTCAAAAC
TGAAGCTTTTTATTTAGGCTTTTCCAAATCAAGGATAAATATCTTACGCACGATATCTAGTGACAGAGGAGAAAGTGGAAAATGACCTCA
AGGAAGCTACGGGCACAACTGGAAGCTTTGTAGAAATTAAACATATTCAAGGAGCAAGAAATGAACTTTCAGCAGTCTAAATTTTCTAAA
TAACCAATAGTTGCCAATCTAAAATGGCAGAGAAGATGAAATTTGATAAACTGAATTTTTTTTAAAAATCCATTTACCCTACAGGTTTGC
ATTTGTTTGCTGAAATTTACCTTTTTTTAGTTATATATATGTGTGTGTGTGTGTGTAATTTCTGCCAATAAATTCTAAATTACAAAGGTA
AGAGAAAACCTAGTACATTACTAAATATATAAAGTATATGTTCTGATTATGTATACTTGTTCTAGTGTCAAGTCTTTTTAAGTGGGTTTT
TAAAAGTTTGTTATTGGACTTGAATGGATTTTTGAGACTAGGTTAATTATTTTTGAGGTCTTATCCTAAAAGGCATCTAAGGTACATGAA
TGGAGTATGGTGATTTTATAACATTTTTTATCAGAATGGAAAAAGAACTGTTTAAAAGTTTGATACTTTTAAATAGTTGGTTTTTTTGCT
TACTCTGGTAATGATTTTCTACAAATACATAATAAATTGTTTTTTTGAGTCTATATTCTGTATGCAGTTGAATATCCATTACTTATTCTG
CTGTGCTTTAATAGAATGGAATGTTTACAGGCCCTTAAAATATTATTTTTAAAAAACCTTCTGAAGATACATACCAAAGTTTTTCCAAGA
AGATTTTATAATCAATTTAATAATGTAAGGTTTATCAGATTCTATAATAGTATAGTTATTAAGGCAATTTTATGTTAGAGACTATTTTGT
AATGTAGTGAGTGGTACCTTTATAAGAAAAGTGACTGCCAATATATTTTTATAGCTGATCTTTATAAATTCTAATGTTGAGTTTTTAATG
ATTATTTTAAATGTTTATATAGTTTAGTAAAATTTGCATCTCAAAGTATCATTTTTATATTATGGGACGTTTTCAGATTGGCTAATATTT
GCATTGTAAATTTTGTATGCAGTTTATCTAAAATTCAAAAATACTGTCAGTACACCAGCGTTTAACATCTATATTCCAATTTGTATACAG

>31790_31790_5_FUS-ATF1_FUS_chr16_31195717_ENST00000380244_ATF1_chr12_51207791_ENST00000262053_length(amino acids)=343AA_BP=181
MPVRACADMASNDYTQQATQSYGAYPTQPGQGYSQQSSQPYGQQSYSGYSQSTDTSGYGQSSYSSYGQSQNSYGTQSTPQGYGSTGGYGS
SQSSQSSYGQQSSYPGYGQQPAPSSTSGSYGSSSQSSSYGQPQSGSYSQQPSYGGQQQSYGQQQSYNPPQGYGQQNQYNSSSGGGGGGGG
GVAIAPNGALQLASPGTDGVQGLQTLTMTNSGSTQQGTTILQYAQTSDGQQILVPSNQVVVQTASGDMQTYQIRTTPSATSLPQTVVMTS

--------------------------------------------------------------
>31790_31790_6_FUS-ATF1_FUS_chr16_31195717_ENST00000568685_ATF1_chr12_51207791_ENST00000262053_length(transcript)=2418nt_BP=587nt
AGGCGTCGGTACTCAGCGGTGTTGGAACTTCGTTGCTTGCTTGCCTGTGCGCGCGTGCGCGGACATGGCCTCAAACGATTATACCCAACA
AGCAACCCAAAGCTATGGGGCCTACCCCACCCAGCCCGGGCAGGGCTATTCCCAGCAGAGCAGTCAGCCCTACGGACAGCAGAGTTACAG
TGGTTATAGCCAGTCCACGGACACTTCAGGCTATGGCCAGAGCAGCTATTCTTCTTATGGCCAGAGCCAGAACACAGGCTATGGAACTCA
GTCAACTCCCCAGGGATATGGCTCGACTGGCGGCTATGGCAGTAGCCAGAGCTCCCAATCGTCTTACGGGCAGCAGTCCTCCTACCCTGG
CTATGGCCAGCAGCCAGCTCCCAGCAGCACCTCGGGAAGTTACGGTAGCAGTTCTCAGAGCAGCAGCTATGGGCAGCCCCAGAGTGGGAG
CTACAGCCAGCAGCCTAGCTATGGTGGACAGCAGCAAAGCTATGGACAGCAGCAAAGCTATAATCCCCCTCAGGGCTATGGACAGCAGAA
CCAGTACAACAGCAGCAGTGGTGGTGGAGGTGGAGGTGGAGGTGGAGTTGCCATTGCCCCAAATGGAGCCTTACAGTTGGCAAGTCCAGG
CACAGATGGAGTACAGGGACTTCAGACATTAACCATGACAAATTCAGGCAGTACTCAGCAAGGTACAACTATTCTTCAGTATGCACAGAC
CTCTGATGGACAGCAGATACTTGTGCCCAGCAATCAGGTGGTCGTACAAACTGCATCAGGAGATATGCAAACATATCAGATCCGAACTAC
ACCTTCAGCTACTTCTCTGCCACAAACTGTGGTGATGACATCTCCTGTGACTCTCACCTCTCAGACAACTAAGACAGATGACCCCCAATT
GAAAAGAGAAATAAGGTTAATGAAAAACAGAGAAGCTGCTCGAGAATGTCGCAGAAAGAAGAAAGAATATGTGAAATGCCTGGAAAACCG
AGTTGCAGTCCTGGAAAATCAAAATAAAACTCTAATAGAAGAGTTAAAAACTTTGAAGGATCTTTATTCCAATAAAAGTGTTTGATTCCT
AAGAAAGAAAATATTTTTGTGGACATGCATAAAAATTAAATGGATTTCCTAGTGGAGTTTTATAAATTAAAAGGTCAAAACTGAAGCTTT
TTATTTAGGCTTTTCCAAATCAAGGATAAATATCTTACGCACGATATCTAGTGACAGAGGAGAAAGTGGAAAATGACCTCAAGGAAGCTA
CGGGCACAACTGGAAGCTTTGTAGAAATTAAACATATTCAAGGAGCAAGAAATGAACTTTCAGCAGTCTAAATTTTCTAAATAACCAATA
GTTGCCAATCTAAAATGGCAGAGAAGATGAAATTTGATAAACTGAATTTTTTTTAAAAATCCATTTACCCTACAGGTTTGCATTTGTTTG
CTGAAATTTACCTTTTTTTAGTTATATATATGTGTGTGTGTGTGTGTAATTTCTGCCAATAAATTCTAAATTACAAAGGTAAGAGAAAAC
CTAGTACATTACTAAATATATAAAGTATATGTTCTGATTATGTATACTTGTTCTAGTGTCAAGTCTTTTTAAGTGGGTTTTTAAAAGTTT
GTTATTGGACTTGAATGGATTTTTGAGACTAGGTTAATTATTTTTGAGGTCTTATCCTAAAAGGCATCTAAGGTACATGAATGGAGTATG
GTGATTTTATAACATTTTTTATCAGAATGGAAAAAGAACTGTTTAAAAGTTTGATACTTTTAAATAGTTGGTTTTTTTGCTTACTCTGGT
AATGATTTTCTACAAATACATAATAAATTGTTTTTTTGAGTCTATATTCTGTATGCAGTTGAATATCCATTACTTATTCTGCTGTGCTTT
AATAGAATGGAATGTTTACAGGCCCTTAAAATATTATTTTTAAAAAACCTTCTGAAGATACATACCAAAGTTTTTCCAAGAAGATTTTAT
AATCAATTTAATAATGTAAGGTTTATCAGATTCTATAATAGTATAGTTATTAAGGCAATTTTATGTTAGAGACTATTTTGTAATGTAGTG
AGTGGTACCTTTATAAGAAAAGTGACTGCCAATATATTTTTATAGCTGATCTTTATAAATTCTAATGTTGAGTTTTTAATGATTATTTTA
AATGTTTATATAGTTTAGTAAAATTTGCATCTCAAAGTATCATTTTTATATTATGGGACGTTTTCAGATTGGCTAATATTTGCATTGTAA
ATTTTGTATGCAGTTTATCTAAAATTCAAAAATACTGTCAGTACACCAGCGTTTAACATCTATATTCCAATTTGTATACAGTTTAAAATT

>31790_31790_6_FUS-ATF1_FUS_chr16_31195717_ENST00000568685_ATF1_chr12_51207791_ENST00000262053_length(amino acids)=344AA_BP=182
MPVRACADMASNDYTQQATQSYGAYPTQPGQGYSQQSSQPYGQQSYSGYSQSTDTSGYGQSSYSSYGQSQNTGYGTQSTPQGYGSTGGYG
SSQSSQSSYGQQSSYPGYGQQPAPSSTSGSYGSSSQSSSYGQPQSGSYSQQPSYGGQQQSYGQQQSYNPPQGYGQQNQYNSSSGGGGGGG
GGVAIAPNGALQLASPGTDGVQGLQTLTMTNSGSTQQGTTILQYAQTSDGQQILVPSNQVVVQTASGDMQTYQIRTTPSATSLPQTVVMT

--------------------------------------------------------------

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Fusion Gene PPI Analysis for FUS-ATF1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for FUS-ATF1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for FUS-ATF1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneFUSC1842675AMYOTROPHIC LATERAL SCLEROSIS 6 (disorder)5UNIPROT
HgeneFUSC3468114Juvenile amyotrophic lateral sclerosis5ORPHANET
HgeneFUSC0002736Amyotrophic Lateral Sclerosis2CTD_human;ORPHANET
HgeneFUSC0206634Liposarcoma, Myxoid2CTD_human;ORPHANET
HgeneFUSC0393554Amyotrophic Lateral Sclerosis With Dementia1CTD_human
HgeneFUSC0497327Dementia1GENOMICS_ENGLAND
HgeneFUSC0543859Amyotrophic Lateral Sclerosis, Guam Form1CTD_human
HgeneFUSC3539195TREMOR, HEREDITARY ESSENTIAL, 41CTD_human;UNIPROT
HgeneFUSC3888102Frontotemporal Dementia With Motor Neuron Disease1ORPHANET
TgeneC0032460Polycystic Ovary Syndrome1CTD_human
TgeneC0206651Clear Cell Sarcoma of Soft Tissue1ORPHANET
TgeneC1136382Sclerocystic Ovaries1CTD_human