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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:FUT8-CCDC85C (FusionGDB2 ID:HG2530TG317762)

Fusion Gene Summary for FUT8-CCDC85C

check button Fusion gene summary
Fusion gene informationFusion gene name: FUT8-CCDC85C
Fusion gene ID: hg2530tg317762
HgeneTgene
Gene symbol

FUT8

CCDC85C

Gene ID

2530

317762

Gene namefucosyltransferase 8coiled-coil domain containing 85C
SynonymsCDGF|CDGF1-
Cytomap('FUT8')('CCDC85C')

14q23.3

14q32.2

Type of geneprotein-codingprotein-coding
Descriptionalpha-(1,6)-fucosyltransferaseGDP-L-Fuc:N-acetyl-beta-D-glucosaminide alpha1,6-fucosyltransferaseGDP-fucose--glycoprotein fucosyltransferasealpha1-6FucTfucosyltransferase 8 (alpha (1,6) fucosyltransferase)glycoprotein 6-alpha-L-fucosyltransferasecoiled-coil domain-containing protein 85C
Modification date2020032220200313
UniProtAcc

Q9BYC5

A6NKD9

Ensembl transtripts involved in fusion geneENST00000358307, ENST00000360689, 
ENST00000394585, ENST00000557164, 
ENST00000394586, ENST00000417683, 
ENST00000554765, 
Fusion gene scores* DoF score15 X 10 X 7=10503 X 5 X 2=30
# samples 185
** MAII scorelog2(18/1050*10)=-2.54432051622381
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(5/30*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: FUT8 [Title/Abstract] AND CCDC85C [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointFUT8(65922436)-CCDC85C(100002425), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneFUT8

GO:0018279

protein N-linked glycosylation via asparagine

17172260

HgeneFUT8

GO:0046368

GDP-L-fucose metabolic process

17172260



check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4OVTCGA-13-0916-01AFUT8chr14

65922436

-CCDC85Cchr14

100002425

-
ChimerDB4OVTCGA-13-0916-01AFUT8chr14

65922436

+CCDC85Cchr14

100002425

-


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Fusion Gene ORF analysis for FUT8-CCDC85C

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000358307ENST00000380243FUT8chr14

65922436

+CCDC85Cchr14

100002425

-
5UTR-3CDSENST00000360689ENST00000380243FUT8chr14

65922436

+CCDC85Cchr14

100002425

-
5UTR-3CDSENST00000394585ENST00000380243FUT8chr14

65922436

+CCDC85Cchr14

100002425

-
5UTR-3CDSENST00000557164ENST00000380243FUT8chr14

65922436

+CCDC85Cchr14

100002425

-
5UTR-intronENST00000358307ENST00000555822FUT8chr14

65922436

+CCDC85Cchr14

100002425

-
5UTR-intronENST00000358307ENST00000557769FUT8chr14

65922436

+CCDC85Cchr14

100002425

-
5UTR-intronENST00000360689ENST00000555822FUT8chr14

65922436

+CCDC85Cchr14

100002425

-
5UTR-intronENST00000360689ENST00000557769FUT8chr14

65922436

+CCDC85Cchr14

100002425

-
5UTR-intronENST00000394585ENST00000555822FUT8chr14

65922436

+CCDC85Cchr14

100002425

-
5UTR-intronENST00000394585ENST00000557769FUT8chr14

65922436

+CCDC85Cchr14

100002425

-
5UTR-intronENST00000557164ENST00000555822FUT8chr14

65922436

+CCDC85Cchr14

100002425

-
5UTR-intronENST00000557164ENST00000557769FUT8chr14

65922436

+CCDC85Cchr14

100002425

-
intron-3CDSENST00000394586ENST00000380243FUT8chr14

65922436

+CCDC85Cchr14

100002425

-
intron-3CDSENST00000417683ENST00000380243FUT8chr14

65922436

+CCDC85Cchr14

100002425

-
intron-3CDSENST00000554765ENST00000380243FUT8chr14

65922436

+CCDC85Cchr14

100002425

-
intron-intronENST00000394586ENST00000555822FUT8chr14

65922436

+CCDC85Cchr14

100002425

-
intron-intronENST00000394586ENST00000557769FUT8chr14

65922436

+CCDC85Cchr14

100002425

-
intron-intronENST00000417683ENST00000555822FUT8chr14

65922436

+CCDC85Cchr14

100002425

-
intron-intronENST00000417683ENST00000557769FUT8chr14

65922436

+CCDC85Cchr14

100002425

-
intron-intronENST00000554765ENST00000555822FUT8chr14

65922436

+CCDC85Cchr14

100002425

-
intron-intronENST00000554765ENST00000557769FUT8chr14

65922436

+CCDC85Cchr14

100002425

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for FUT8-CCDC85C


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)


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Fusion Protein Features for FUT8-CCDC85C


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:65922436/:100002425)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FUT8

Q9BYC5

CCDC85C

A6NKD9

FUNCTION: Catalyzes the addition of fucose in alpha 1-6 linkage to the first GlcNAc residue, next to the peptide chains in N-glycans. {ECO:0000269|PubMed:17172260, ECO:0000269|PubMed:29304374, ECO:0000269|PubMed:9133635}.FUNCTION: May play a role in cell-cell adhesion and epithelium development through its interaction with proteins of the beta-catenin family (Probable). May play an important role in cortical development, especially in the maintenance of radial glia (By similarity). {ECO:0000250|UniProtKB:E9Q6B2, ECO:0000305|PubMed:25009281}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for FUT8-CCDC85C


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for FUT8-CCDC85C


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for FUT8-CCDC85C


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for FUT8-CCDC85C


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneFUT8C4693905CONGENITAL DISORDER OF GLYCOSYLATION WITH DEFECTIVE FUCOSYLATION3GENOMICS_ENGLAND;UNIPROT
HgeneFUT8C0036341Schizophrenia2PSYGENET
HgeneFUT8C0036572Seizures1GENOMICS_ENGLAND
HgeneFUT8C0809983Schizophrenia and related disorders1PSYGENET
HgeneFUT8C3714756Intellectual Disability1GENOMICS_ENGLAND