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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ANKRD18A-ZNF521 (FusionGDB2 ID:HG253650TG25925)

Fusion Gene Summary for ANKRD18A-ZNF521

check button Fusion gene summary
Fusion gene informationFusion gene name: ANKRD18A-ZNF521
Fusion gene ID: hg253650tg25925
HgeneTgene
Gene symbol

ANKRD18A

ZNF521

Gene ID

253650

25925

Gene nameankyrin repeat domain 18Azinc finger protein 521
Synonyms-EHZF|Evi3
Cytomap('ANKRD18A')('ZNF521')

9p13.1

18q11.2

Type of geneprotein-codingprotein-coding
Descriptionankyrin repeat domain-containing protein 18Azinc finger protein 521LYST-interacting protein 3early hematopoietic zinc finger protein
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000313339, ENST00000566717, 
ENST00000607974, ENST00000357072, 
ENST00000399703, ENST00000475234, 
Fusion gene scores* DoF score3 X 3 X 3=2713 X 10 X 9=1170
# samples 315
** MAII scorelog2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(15/1170*10)=-2.96347412397489
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ANKRD18A [Title/Abstract] AND ZNF521 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointANKRD18A(38572003)-ZNF521(22672045), # samples:1
Anticipated loss of major functional domain due to fusion event.ANKRD18A-ZNF521 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ANKRD18A-ZNF521 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ANKRD18A-ZNF521 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ANKRD18A-ZNF521 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ANKRD18A-ZNF521 seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF.
ANKRD18A-ZNF521 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
ANKRD18A-ZNF521 seems lost the major protein functional domain in Tgene partner, which is a transcription factor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across ANKRD18A (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across ZNF521 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SARCTCGA-DX-AB2T-01AANKRD18Achr9

38572003

-ZNF521chr18

22672045

-


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Fusion Gene ORF analysis for ANKRD18A-ZNF521

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000313339ENST00000579111ANKRD18Achr9

38572003

-ZNF521chr18

22672045

-
5CDS-intronENST00000566717ENST00000579111ANKRD18Achr9

38572003

-ZNF521chr18

22672045

-
5CDS-intronENST00000607974ENST00000579111ANKRD18Achr9

38572003

-ZNF521chr18

22672045

-
5UTR-3CDSENST00000357072ENST00000361524ANKRD18Achr9

38572003

-ZNF521chr18

22672045

-
5UTR-3CDSENST00000357072ENST00000538137ANKRD18Achr9

38572003

-ZNF521chr18

22672045

-
5UTR-3CDSENST00000357072ENST00000584787ANKRD18Achr9

38572003

-ZNF521chr18

22672045

-
5UTR-intronENST00000357072ENST00000579111ANKRD18Achr9

38572003

-ZNF521chr18

22672045

-
Frame-shiftENST00000313339ENST00000361524ANKRD18Achr9

38572003

-ZNF521chr18

22672045

-
Frame-shiftENST00000313339ENST00000538137ANKRD18Achr9

38572003

-ZNF521chr18

22672045

-
Frame-shiftENST00000313339ENST00000584787ANKRD18Achr9

38572003

-ZNF521chr18

22672045

-
Frame-shiftENST00000566717ENST00000361524ANKRD18Achr9

38572003

-ZNF521chr18

22672045

-
Frame-shiftENST00000566717ENST00000538137ANKRD18Achr9

38572003

-ZNF521chr18

22672045

-
Frame-shiftENST00000566717ENST00000584787ANKRD18Achr9

38572003

-ZNF521chr18

22672045

-
In-frameENST00000607974ENST00000361524ANKRD18Achr9

38572003

-ZNF521chr18

22672045

-
In-frameENST00000607974ENST00000538137ANKRD18Achr9

38572003

-ZNF521chr18

22672045

-
In-frameENST00000607974ENST00000584787ANKRD18Achr9

38572003

-ZNF521chr18

22672045

-
intron-3CDSENST00000399703ENST00000361524ANKRD18Achr9

38572003

-ZNF521chr18

22672045

-
intron-3CDSENST00000399703ENST00000538137ANKRD18Achr9

38572003

-ZNF521chr18

22672045

-
intron-3CDSENST00000399703ENST00000584787ANKRD18Achr9

38572003

-ZNF521chr18

22672045

-
intron-3CDSENST00000475234ENST00000361524ANKRD18Achr9

38572003

-ZNF521chr18

22672045

-
intron-3CDSENST00000475234ENST00000538137ANKRD18Achr9

38572003

-ZNF521chr18

22672045

-
intron-3CDSENST00000475234ENST00000584787ANKRD18Achr9

38572003

-ZNF521chr18

22672045

-
intron-intronENST00000399703ENST00000579111ANKRD18Achr9

38572003

-ZNF521chr18

22672045

-
intron-intronENST00000475234ENST00000579111ANKRD18Achr9

38572003

-ZNF521chr18

22672045

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000607974ANKRD18Achr938572003-ENST00000361524ZNF521chr1822672045-14914270704234
ENST00000607974ANKRD18Achr938572003-ENST00000584787ZNF521chr1822672045-9924270704234
ENST00000607974ANKRD18Achr938572003-ENST00000538137ZNF521chr1822672045-8244270704234

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000607974ENST00000361524ANKRD18Achr938572003-ZNF521chr1822672045-0.0044465940.99555343
ENST00000607974ENST00000584787ANKRD18Achr938572003-ZNF521chr1822672045-0.0050707410.9949293
ENST00000607974ENST00000538137ANKRD18Achr938572003-ZNF521chr1822672045-0.0050894140.99491066

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Fusion Genomic Features for ANKRD18A-ZNF521


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for ANKRD18A-ZNF521


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr9:38572003/chr18:22672045)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneZNF521chr9:38572003chr18:22672045ENST00000361524481225_124712191312.0Zinc fingerC2H2-type 28
TgeneZNF521chr9:38572003chr18:22672045ENST00000361524481256_127912191312.0Zinc fingerC2H2-type 29
TgeneZNF521chr9:38572003chr18:22672045ENST00000361524481286_130912191312.0Zinc fingerC2H2-type 30
TgeneZNF521chr9:38572003chr18:22672045ENST00000538137481225_124712191312.0Zinc fingerC2H2-type 28
TgeneZNF521chr9:38572003chr18:22672045ENST00000538137481256_127912191312.0Zinc fingerC2H2-type 29
TgeneZNF521chr9:38572003chr18:22672045ENST00000538137481286_130912191312.0Zinc fingerC2H2-type 30

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneANKRD18Achr9:38572003chr18:22672045ENST00000399703-116278_3100993.0Coiled coilOntology_term=ECO:0000255
HgeneANKRD18Achr9:38572003chr18:22672045ENST00000399703-116378_6180993.0Coiled coilOntology_term=ECO:0000255
HgeneANKRD18Achr9:38572003chr18:22672045ENST00000399703-116683_7130993.0Coiled coilOntology_term=ECO:0000255
HgeneANKRD18Achr9:38572003chr18:22672045ENST00000399703-116743_8990993.0Coiled coilOntology_term=ECO:0000255
HgeneANKRD18Achr9:38572003chr18:22672045ENST00000399703-116100_1290993.0RepeatNote=ANK 2
HgeneANKRD18Achr9:38572003chr18:22672045ENST00000399703-116133_1620993.0RepeatNote=ANK 3
HgeneANKRD18Achr9:38572003chr18:22672045ENST00000399703-116166_1950993.0RepeatNote=ANK 4
HgeneANKRD18Achr9:38572003chr18:22672045ENST00000399703-116199_2280993.0RepeatNote=ANK 5
HgeneANKRD18Achr9:38572003chr18:22672045ENST00000399703-11667_960993.0RepeatNote=ANK 1
TgeneZNF521chr9:38572003chr18:22672045ENST00000361524481020_104212191312.0Zinc fingerC2H2-type 24
TgeneZNF521chr9:38572003chr18:22672045ENST00000361524481065_108312191312.0Zinc fingerC2H2-type 25%3B degenerate
TgeneZNF521chr9:38572003chr18:22672045ENST00000361524481138_116112191312.0Zinc fingerC2H2-type 26
TgeneZNF521chr9:38572003chr18:22672045ENST0000036152448118_14012191312.0Zinc fingerC2H2-type 2
TgeneZNF521chr9:38572003chr18:22672045ENST00000361524481195_121712191312.0Zinc fingerC2H2-type 27
TgeneZNF521chr9:38572003chr18:22672045ENST0000036152448146_16812191312.0Zinc fingerC2H2-type 3
TgeneZNF521chr9:38572003chr18:22672045ENST0000036152448174_19612191312.0Zinc fingerC2H2-type 4
TgeneZNF521chr9:38572003chr18:22672045ENST0000036152448202_22412191312.0Zinc fingerC2H2-type 5
TgeneZNF521chr9:38572003chr18:22672045ENST0000036152448246_26912191312.0Zinc fingerC2H2-type 6
TgeneZNF521chr9:38572003chr18:22672045ENST0000036152448281_30412191312.0Zinc fingerC2H2-type 7
TgeneZNF521chr9:38572003chr18:22672045ENST0000036152448310_33212191312.0Zinc fingerC2H2-type 8
TgeneZNF521chr9:38572003chr18:22672045ENST0000036152448405_42912191312.0Zinc fingerC2H2-type 9%3B degenerate
TgeneZNF521chr9:38572003chr18:22672045ENST0000036152448437_46012191312.0Zinc fingerC2H2-type 10
TgeneZNF521chr9:38572003chr18:22672045ENST0000036152448477_50012191312.0Zinc fingerC2H2-type 11
TgeneZNF521chr9:38572003chr18:22672045ENST000003615244847_6712191312.0Zinc fingerC2H2-type 1%3B degenerate
TgeneZNF521chr9:38572003chr18:22672045ENST0000036152448513_53612191312.0Zinc fingerC2H2-type 12
TgeneZNF521chr9:38572003chr18:22672045ENST0000036152448560_58512191312.0Zinc fingerC2H2-type 13%3B atypical
TgeneZNF521chr9:38572003chr18:22672045ENST0000036152448634_65612191312.0Zinc fingerC2H2-type 14
TgeneZNF521chr9:38572003chr18:22672045ENST0000036152448664_68612191312.0Zinc fingerC2H2-type 15
TgeneZNF521chr9:38572003chr18:22672045ENST0000036152448694_71712191312.0Zinc fingerC2H2-type 16
TgeneZNF521chr9:38572003chr18:22672045ENST0000036152448722_74512191312.0Zinc fingerC2H2-type 17
TgeneZNF521chr9:38572003chr18:22672045ENST0000036152448752_77512191312.0Zinc fingerC2H2-type 18
TgeneZNF521chr9:38572003chr18:22672045ENST0000036152448783_80512191312.0Zinc fingerC2H2-type 19
TgeneZNF521chr9:38572003chr18:22672045ENST0000036152448809_83212191312.0Zinc fingerC2H2-type 20
TgeneZNF521chr9:38572003chr18:22672045ENST0000036152448886_90812191312.0Zinc fingerC2H2-type 21%3B degenerate
TgeneZNF521chr9:38572003chr18:22672045ENST0000036152448930_95212191312.0Zinc fingerC2H2-type 22
TgeneZNF521chr9:38572003chr18:22672045ENST0000036152448959_98112191312.0Zinc fingerC2H2-type 23
TgeneZNF521chr9:38572003chr18:22672045ENST00000538137481020_104212191312.0Zinc fingerC2H2-type 24
TgeneZNF521chr9:38572003chr18:22672045ENST00000538137481065_108312191312.0Zinc fingerC2H2-type 25%3B degenerate
TgeneZNF521chr9:38572003chr18:22672045ENST00000538137481138_116112191312.0Zinc fingerC2H2-type 26
TgeneZNF521chr9:38572003chr18:22672045ENST0000053813748118_14012191312.0Zinc fingerC2H2-type 2
TgeneZNF521chr9:38572003chr18:22672045ENST00000538137481195_121712191312.0Zinc fingerC2H2-type 27
TgeneZNF521chr9:38572003chr18:22672045ENST0000053813748146_16812191312.0Zinc fingerC2H2-type 3
TgeneZNF521chr9:38572003chr18:22672045ENST0000053813748174_19612191312.0Zinc fingerC2H2-type 4
TgeneZNF521chr9:38572003chr18:22672045ENST0000053813748202_22412191312.0Zinc fingerC2H2-type 5
TgeneZNF521chr9:38572003chr18:22672045ENST0000053813748246_26912191312.0Zinc fingerC2H2-type 6
TgeneZNF521chr9:38572003chr18:22672045ENST0000053813748281_30412191312.0Zinc fingerC2H2-type 7
TgeneZNF521chr9:38572003chr18:22672045ENST0000053813748310_33212191312.0Zinc fingerC2H2-type 8
TgeneZNF521chr9:38572003chr18:22672045ENST0000053813748405_42912191312.0Zinc fingerC2H2-type 9%3B degenerate
TgeneZNF521chr9:38572003chr18:22672045ENST0000053813748437_46012191312.0Zinc fingerC2H2-type 10
TgeneZNF521chr9:38572003chr18:22672045ENST0000053813748477_50012191312.0Zinc fingerC2H2-type 11
TgeneZNF521chr9:38572003chr18:22672045ENST000005381374847_6712191312.0Zinc fingerC2H2-type 1%3B degenerate
TgeneZNF521chr9:38572003chr18:22672045ENST0000053813748513_53612191312.0Zinc fingerC2H2-type 12
TgeneZNF521chr9:38572003chr18:22672045ENST0000053813748560_58512191312.0Zinc fingerC2H2-type 13%3B atypical
TgeneZNF521chr9:38572003chr18:22672045ENST0000053813748634_65612191312.0Zinc fingerC2H2-type 14
TgeneZNF521chr9:38572003chr18:22672045ENST0000053813748664_68612191312.0Zinc fingerC2H2-type 15
TgeneZNF521chr9:38572003chr18:22672045ENST0000053813748694_71712191312.0Zinc fingerC2H2-type 16
TgeneZNF521chr9:38572003chr18:22672045ENST0000053813748722_74512191312.0Zinc fingerC2H2-type 17
TgeneZNF521chr9:38572003chr18:22672045ENST0000053813748752_77512191312.0Zinc fingerC2H2-type 18
TgeneZNF521chr9:38572003chr18:22672045ENST0000053813748783_80512191312.0Zinc fingerC2H2-type 19
TgeneZNF521chr9:38572003chr18:22672045ENST0000053813748809_83212191312.0Zinc fingerC2H2-type 20
TgeneZNF521chr9:38572003chr18:22672045ENST0000053813748886_90812191312.0Zinc fingerC2H2-type 21%3B degenerate
TgeneZNF521chr9:38572003chr18:22672045ENST0000053813748930_95212191312.0Zinc fingerC2H2-type 22
TgeneZNF521chr9:38572003chr18:22672045ENST0000053813748959_98112191312.0Zinc fingerC2H2-type 23


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Fusion Gene Sequence for ANKRD18A-ZNF521


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>4619_4619_1_ANKRD18A-ZNF521_ANKRD18A_chr9_38572003_ENST00000607974_ZNF521_chr18_22672045_ENST00000361524_length(transcript)=1491nt_BP=427nt
ATGAAAACTGCTTATGAAGAGGTTACAACTGAATTAGAAGAATTTAAGGAAGCCTTTGCAGGAGCAGTGAAAGCTAACAATTCCATGTCA
AAAAAATTAATGAAATCGGATAAGAAAATAGCAGTGATCAGCACCAAGCTCTTTACGGAGAAACAGCGGATGAAATATTTTCTCAGCACT
CTTCCTACAAGGCCAGAACCAGAGTTACCTTGTGTTGAAAATCTTAATAGTATAGAACTCAACAGAAAATATATTCCCAAAACGGCCATA
AGAATTCCTACTTCAAACCCACAGACTTCAAATAACTGCAAGAACTTCTTGACTGAGATGGAGCTGGACCGTGTAGAACAAATAATTACA
GGAACAAAGAAAAGTTTTGCTATGTTGAGCACTTGCTCCCGTCTACTTTCTTTTGTAGAATCCACTGATGAAGGACTGAACCATGAATGC
AAACTCTGCAGCCAGACCTTTGACTCTCCTGCCAAACTCCAGTGCCACCTGATAGAGCACAGCTTCGAAGGGATGGGAGGCACCTTCAAG
TGTCCAGTCTGCTTTACAGTATTTGTTCAAGCAAACAAGTTGCAGCAGCATATTTTCTCTGCCCATGGACAAGAAGACAAGATCTATGAC
TGTACACAATGTCCACAGAAGTTTTTCTTCCAAACAGAGCTGCAGAATCATACAATGACCCAACACAGCAGTTAGTGCAAGTACAGTCTC
TCAAGGAGAATTGATTTTGTGGCACAAAAAGGGAACATGTTTTACTCTTTGCACGAAACTTTCATTGTTAATGTATATTATTCAGAAACA
TTGTATTGTACCATAAAACTTGTATTATCAAACTGTTGGATGTTCATGTGTTTGAACTTTTGCGCACCGGATAGACCCCTTGTATATAAA
GTGTTGCACATGTATTATGTCGTCTGATACTAAAATGGTCTTATAAAGACAAGTGGACTTGGGCCCTATTCAGGCAAGATTAAAAAAAAA
AAAAGACTATGACCAAAATGGCTTAAGATAAAGTATTTTTAAGGAAGAAAGATTAAAAACAACTGTTATACATGAGACTATGGTTGGACT
TCCTTTTCTTTACACTTAAGCCTAGAATTTCTCTTTAGGTATATCAGCGCTTAAATCCAAGACTATTTTTTATTGCTGAAGATTCTTGCA
AACCATGAAGAGATGTTCTCACAGAACAGAACCCCACAGCTGGATAAGGCCCGTATATATATATTTGTAAGCCTTGCAATGTGACAGGTA
GCATCACTATATATGCAATAGTTGTTATGTAGACTGTCAAAGAATTTTTTTTTCCCTGGATACATTTGAAGCTTTGAGTGTTCAAGGTTT
TCCTTAATGATTTCACGCAGCCAAATTCTTGAATCAGTTGAACTAACCTGTATGTTACTGTTATTAATGTTTACTCTGCAGTCTGAACCT

>4619_4619_1_ANKRD18A-ZNF521_ANKRD18A_chr9_38572003_ENST00000607974_ZNF521_chr18_22672045_ENST00000361524_length(amino acids)=234AA_BP=141
MKTAYEEVTTELEEFKEAFAGAVKANNSMSKKLMKSDKKIAVISTKLFTEKQRMKYFLSTLPTRPEPELPCVENLNSIELNRKYIPKTAI
RIPTSNPQTSNNCKNFLTEMELDRVEQIITGTKKSFAMLSTCSRLLSFVESTDEGLNHECKLCSQTFDSPAKLQCHLIEHSFEGMGGTFK

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>4619_4619_2_ANKRD18A-ZNF521_ANKRD18A_chr9_38572003_ENST00000607974_ZNF521_chr18_22672045_ENST00000538137_length(transcript)=824nt_BP=427nt
ATGAAAACTGCTTATGAAGAGGTTACAACTGAATTAGAAGAATTTAAGGAAGCCTTTGCAGGAGCAGTGAAAGCTAACAATTCCATGTCA
AAAAAATTAATGAAATCGGATAAGAAAATAGCAGTGATCAGCACCAAGCTCTTTACGGAGAAACAGCGGATGAAATATTTTCTCAGCACT
CTTCCTACAAGGCCAGAACCAGAGTTACCTTGTGTTGAAAATCTTAATAGTATAGAACTCAACAGAAAATATATTCCCAAAACGGCCATA
AGAATTCCTACTTCAAACCCACAGACTTCAAATAACTGCAAGAACTTCTTGACTGAGATGGAGCTGGACCGTGTAGAACAAATAATTACA
GGAACAAAGAAAAGTTTTGCTATGTTGAGCACTTGCTCCCGTCTACTTTCTTTTGTAGAATCCACTGATGAAGGACTGAACCATGAATGC
AAACTCTGCAGCCAGACCTTTGACTCTCCTGCCAAACTCCAGTGCCACCTGATAGAGCACAGCTTCGAAGGGATGGGAGGCACCTTCAAG
TGTCCAGTCTGCTTTACAGTATTTGTTCAAGCAAACAAGTTGCAGCAGCATATTTTCTCTGCCCATGGACAAGAAGACAAGATCTATGAC
TGTACACAATGTCCACAGAAGTTTTTCTTCCAAACAGAGCTGCAGAATCATACAATGACCCAACACAGCAGTTAGTGCAAGTACAGTCTC
TCAAGGAGAATTGATTTTGTGGCACAAAAAGGGAACATGTTTTACTCTTTGCACGAAACTTTCATTGTTAATGTATATTATTCAGAAACA

>4619_4619_2_ANKRD18A-ZNF521_ANKRD18A_chr9_38572003_ENST00000607974_ZNF521_chr18_22672045_ENST00000538137_length(amino acids)=234AA_BP=141
MKTAYEEVTTELEEFKEAFAGAVKANNSMSKKLMKSDKKIAVISTKLFTEKQRMKYFLSTLPTRPEPELPCVENLNSIELNRKYIPKTAI
RIPTSNPQTSNNCKNFLTEMELDRVEQIITGTKKSFAMLSTCSRLLSFVESTDEGLNHECKLCSQTFDSPAKLQCHLIEHSFEGMGGTFK

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>4619_4619_3_ANKRD18A-ZNF521_ANKRD18A_chr9_38572003_ENST00000607974_ZNF521_chr18_22672045_ENST00000584787_length(transcript)=992nt_BP=427nt
ATGAAAACTGCTTATGAAGAGGTTACAACTGAATTAGAAGAATTTAAGGAAGCCTTTGCAGGAGCAGTGAAAGCTAACAATTCCATGTCA
AAAAAATTAATGAAATCGGATAAGAAAATAGCAGTGATCAGCACCAAGCTCTTTACGGAGAAACAGCGGATGAAATATTTTCTCAGCACT
CTTCCTACAAGGCCAGAACCAGAGTTACCTTGTGTTGAAAATCTTAATAGTATAGAACTCAACAGAAAATATATTCCCAAAACGGCCATA
AGAATTCCTACTTCAAACCCACAGACTTCAAATAACTGCAAGAACTTCTTGACTGAGATGGAGCTGGACCGTGTAGAACAAATAATTACA
GGAACAAAGAAAAGTTTTGCTATGTTGAGCACTTGCTCCCGTCTACTTTCTTTTGTAGAATCCACTGATGAAGGACTGAACCATGAATGC
AAACTCTGCAGCCAGACCTTTGACTCTCCTGCCAAACTCCAGTGCCACCTGATAGAGCACAGCTTCGAAGGGATGGGAGGCACCTTCAAG
TGTCCAGTCTGCTTTACAGTATTTGTTCAAGCAAACAAGTTGCAGCAGCATATTTTCTCTGCCCATGGACAAGAAGACAAGATCTATGAC
TGTACACAATGTCCACAGAAGTTTTTCTTCCAAACAGAGCTGCAGAATCATACAATGACCCAACACAGCAGTTAGTGCAAGTACAGTCTC
TCAAGGAGAATTGATTTTGTGGCACAAAAAGGGAACATGTTTTACTCTTTGCACGAAACTTTCATTGTTAATGTATATTATTCAGAAACA
TTGTATTGTACCATAAAACTTGTATTATCAAACTGTTGGATGTTCATGTGTTTGAACTTTTGCGCACCGGATAGACCCCTTGTATATAAA
GTGTTGCACATGTATTATGTCGTCTGATACTAAAATGGTCTTATAAAGACAAGTGGACTTGGGCCCTATTCAGGCAAGATTAAAAAAAAA

>4619_4619_3_ANKRD18A-ZNF521_ANKRD18A_chr9_38572003_ENST00000607974_ZNF521_chr18_22672045_ENST00000584787_length(amino acids)=234AA_BP=141
MKTAYEEVTTELEEFKEAFAGAVKANNSMSKKLMKSDKKIAVISTKLFTEKQRMKYFLSTLPTRPEPELPCVENLNSIELNRKYIPKTAI
RIPTSNPQTSNNCKNFLTEMELDRVEQIITGTKKSFAMLSTCSRLLSFVESTDEGLNHECKLCSQTFDSPAKLQCHLIEHSFEGMGGTFK

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Fusion Gene PPI Analysis for ANKRD18A-ZNF521


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ANKRD18A-ZNF521


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ANKRD18A-ZNF521


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneANKRD18AC0024121Lung Neoplasms1CTD_human
HgeneANKRD18AC0242379Malignant neoplasm of lung1CTD_human