Fusion Gene Studies
in Kim Lab

FusionBase FusionGDB FusionGDB2 FusionPDB FusionNeoAntigen FusionAI FusionNW FGviewer Publication Contact
FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:MSRB3-CNOT2 (FusionGDB2 ID:HG253827TG4848)

Fusion Gene Summary for MSRB3-CNOT2

check button Fusion gene summary
Fusion gene informationFusion gene name: MSRB3-CNOT2
Fusion gene ID: hg253827tg4848
HgeneTgene
Gene symbol

MSRB3

CNOT2

Gene ID

253827

4848

Gene namemethionine sulfoxide reductase B3CCR4-NOT transcription complex subunit 2
SynonymsDFNB74CDC36|HSPC131|IDNADFS|NOT2|NOT2H
Cytomap('MSRB3')('CNOT2')

12q14.3

12q15

Type of geneprotein-codingprotein-coding
Descriptionmethionine-R-sulfoxide reductase B3methionine-R-sulfoxide reductase B3, mitochondrialCCR4-NOT transcription complex subunit 2CCR4-associated factor 2negative regulator of transcription 2
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000538725, ENST00000355192, 
ENST00000540804, ENST00000308259, 
ENST00000535664, 
Fusion gene scores* DoF score7 X 5 X 4=14027 X 20 X 10=5400
# samples 729
** MAII scorelog2(7/140*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(29/5400*10)=-4.21883460192326
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MSRB3 [Title/Abstract] AND CNOT2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointMSRB3(65672645)-CNOT2(70729218), # samples:2
Anticipated loss of major functional domain due to fusion event.MSRB3-CNOT2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
MSRB3-CNOT2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
MSRB3-CNOT2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
MSRB3-CNOT2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneMSRB3

GO:0030091

protein repair

14699060

TgeneCNOT2

GO:0000122

negative regulation of transcription by RNA polymerase II

14707134|16712523


check buttonFusion gene breakpoints across MSRB3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across CNOT2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SARCTCGA-DX-AB2H-01AMSRB3chr12

65672645

-CNOT2chr12

70729218

+
ChimerDB4SARCTCGA-DX-AB2H-01AMSRB3chr12

65672645

+CNOT2chr12

70729218

+


Top

Fusion Gene ORF analysis for MSRB3-CNOT2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000538725ENST00000229195MSRB3chr12

65672645

+CNOT2chr12

70729218

+
3UTR-3CDSENST00000538725ENST00000418359MSRB3chr12

65672645

+CNOT2chr12

70729218

+
3UTR-3UTRENST00000538725ENST00000548230MSRB3chr12

65672645

+CNOT2chr12

70729218

+
3UTR-5UTRENST00000538725ENST00000551483MSRB3chr12

65672645

+CNOT2chr12

70729218

+
5CDS-3UTRENST00000355192ENST00000548230MSRB3chr12

65672645

+CNOT2chr12

70729218

+
5CDS-3UTRENST00000540804ENST00000548230MSRB3chr12

65672645

+CNOT2chr12

70729218

+
5CDS-5UTRENST00000355192ENST00000551483MSRB3chr12

65672645

+CNOT2chr12

70729218

+
5CDS-5UTRENST00000540804ENST00000551483MSRB3chr12

65672645

+CNOT2chr12

70729218

+
5UTR-3CDSENST00000308259ENST00000229195MSRB3chr12

65672645

+CNOT2chr12

70729218

+
5UTR-3CDSENST00000308259ENST00000418359MSRB3chr12

65672645

+CNOT2chr12

70729218

+
5UTR-3CDSENST00000535664ENST00000229195MSRB3chr12

65672645

+CNOT2chr12

70729218

+
5UTR-3CDSENST00000535664ENST00000418359MSRB3chr12

65672645

+CNOT2chr12

70729218

+
5UTR-3UTRENST00000308259ENST00000548230MSRB3chr12

65672645

+CNOT2chr12

70729218

+
5UTR-3UTRENST00000535664ENST00000548230MSRB3chr12

65672645

+CNOT2chr12

70729218

+
5UTR-5UTRENST00000308259ENST00000551483MSRB3chr12

65672645

+CNOT2chr12

70729218

+
5UTR-5UTRENST00000535664ENST00000551483MSRB3chr12

65672645

+CNOT2chr12

70729218

+
In-frameENST00000355192ENST00000229195MSRB3chr12

65672645

+CNOT2chr12

70729218

+
In-frameENST00000355192ENST00000418359MSRB3chr12

65672645

+CNOT2chr12

70729218

+
In-frameENST00000540804ENST00000229195MSRB3chr12

65672645

+CNOT2chr12

70729218

+
In-frameENST00000540804ENST00000418359MSRB3chr12

65672645

+CNOT2chr12

70729218

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000355192MSRB3chr1265672645+ENST00000229195CNOT2chr1270729218+22752231111196361
ENST00000355192MSRB3chr1265672645+ENST00000418359CNOT2chr1270729218+22752231111196361
ENST00000540804MSRB3chr1265672645+ENST00000229195CNOT2chr1270729218+2186134221107361
ENST00000540804MSRB3chr1265672645+ENST00000418359CNOT2chr1270729218+2186134221107361

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000355192ENST00000229195MSRB3chr1265672645+CNOT2chr1270729218+0.0003352960.99966466
ENST00000355192ENST00000418359MSRB3chr1265672645+CNOT2chr1270729218+0.0003352960.99966466
ENST00000540804ENST00000229195MSRB3chr1265672645+CNOT2chr1270729218+0.0003215730.9996785
ENST00000540804ENST00000418359MSRB3chr1265672645+CNOT2chr1270729218+0.0003215730.9996785

Top

Fusion Genomic Features for MSRB3-CNOT2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

Top

Fusion Protein Features for MSRB3-CNOT2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:65672645/chr12:70729218)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneCNOT2chr12:65672645chr12:70729218ENST00000229195616437_540216541.0RegionNote=Repressor domain
TgeneCNOT2chr12:65672645chr12:70729218ENST00000418359717437_540216541.0RegionNote=Repressor domain
TgeneCNOT2chr12:65672645chr12:70729218ENST0000055148307437_5400192.0RegionNote=Repressor domain

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMSRB3chr12:65672645chr12:70729218ENST00000308259+1747_1690186.0DomainMsrB
HgeneMSRB3chr12:65672645chr12:70729218ENST00000355192+1647_16932193.0DomainMsrB
HgeneMSRB3chr12:65672645chr12:70729218ENST00000535664+1847_1690186.0DomainMsrB
HgeneMSRB3chr12:65672645chr12:70729218ENST00000308259+17189_1920186.0MotifEndoplasmic reticulum retention signal
HgeneMSRB3chr12:65672645chr12:70729218ENST00000355192+16189_19232193.0MotifEndoplasmic reticulum retention signal
HgeneMSRB3chr12:65672645chr12:70729218ENST00000535664+18189_1920186.0MotifEndoplasmic reticulum retention signal


Top

Fusion Gene Sequence for MSRB3-CNOT2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>55425_55425_1_MSRB3-CNOT2_MSRB3_chr12_65672645_ENST00000355192_CNOT2_chr12_70729218_ENST00000229195_length(transcript)=2275nt_BP=223nt
ATATTTGGACTCGGCTGCCCGTGCCCAGGAATTTCCCGTCATGCCTCCCGCCGCCCCGTCCGTCGCCCGGAGCCGGGGAGGGAGGGAGCG
AGGTTCGGACACCGGCGGCGGCTGCCTGGCCTTTCCATGAGCCCGCGGCGGACCCTCCCGCGCCCCCTCTCGCTCTGCCTCTCCCTCTGC
CTCTGCCTCTGCCTGGCCGCGGCTCTGGGAAGTGCGCAGTCCGACGGAAGTGAAAATGTGACAGGATTGGACCTTTCAGATTTCCCAGCA
TTAGCAGACCGAAACAGGAGGGAAGGAAGTGGTAACCCAACTCCATTAATAAACCCCTTGGCTGGAAGAGCTCCTTATGTTGGAATGGTA
ACAAAACCAGCAAATGAACAATCCCAGGACTTCTCAATACACAATGAAGATTTTCCAGCATTACCAGGCTCCAGCTATAAAGATCCAACA
TCAAGTAATGATGACAGTAAATCTAATTTGAATACATCTGGCAAGACAACTTCAAGTACAGATGGACCCAAATTCCCTGGAGATAAAAGT
TCAACAACACAAAATAATAACCAGCAGAAAAAAGGGATCCAGGTGTTACCTGATGGTCGGGTTACTAACATTCCTCAAGGGATGGTGACG
GACCAATTTGGAATGATTGGCCTGTTAACATTTATCAGGGCAGCAGAGACAGACCCAGGAATGGTACATCTTGCATTAGGAAGTGACTTA
ACAACATTAGGCCTCAATCTGAACTCTCCTGAAAATCTCTACCCCAAATTTGCGTCACCCTGGGCATCTTCACCTTGTCGACCTCAAGAC
ATAGACTTCCATGTTCCATCTGAGTACTTAACGAACATTCACATTAGGGATAAGCTGGCTGCAATAAAACTTGGCCGATATGGTGAAGAC
CTTCTCTTCTATCTCTATTACATGAATGGAGGAGACGTATTACAACTTTTAGCTGCAGTGGAGCTTTTTAACCGTGATTGGAGATACCAC
AAAGAAGAACGAGTATGGATTACCAGGGCACCAGGCATGGAGCCAACAATGAAAACCAATACCTATGAGAGGGGAACATATTACTTCTTT
GACTGTCTTAACTGGAGGAAAGTAGCTAAGGAGTTCCATCTGGAATATGACAAATTAGAAGAACGGCCTCACCTGCCATCCACCTTCAAC
TACAACCCTGCTCAGCAAGCCTTCTAAAAAAAAAAAAAAAAAAAAAAAAAGACTTCCCTTTTCTTGGGGTATGGCTGTCTCAGCACAATA
CTCAACATAACTGCAGAACTGATGTGGCTCAGGCACCCTGGTTTTAATTCCTTGAGGATCTGGCAATTGGCTTACGCAAAAGGTCACCAT
TTGAGGTCCTGCCTTACTAATTATGTGCTGCCCAACAACTAAATTTGTAATTTGTTTTTCTCTAGTTTGAGCAGGGTCTGAATTTTTTCA
TTTATTTCCTTTTTTGCCAGCAGACAGACTTGAGTCTGTAAAGACAAGCAAATACACTGACAGAAGTTTACCATAGTTTCTAAAATGTAA
AAAAGAAAACCCCCAAAAGACTCAAGAAAATTAGACCACAAATTTTGCATTGTTCATTGTAGCACTATTGGTAATAAAATAACAAATGTT
TGTGCATTTTTATGTGAAGATCCTTCTCGTATTTCATTTGGAAAGATGAGCAAGAGGTCTGCTTCCTTCATTTTACTTCCCCTTCTGTTT
TTGAAAGGCAGTTTCGCCAAGCTTAATGCAAGAATATCTGACTGTTTAGAAGAAAGATATTGCCACAATCTCTGGATGGTTTTCCAGGGT
TGTGTTATTACTGAGCTTCATCTTTCCAGAATGAGCAAAACACTGTCCAGTCTTTGTTACGATTTTGTAATAAATGTGTACATTTTTTTT
AAATTTTTGGACATCACATGAATAAAGGTATGTATGTACGAATGTGTATATATTATATATATGACATCTATTTTGGAAAATGTTTGCCCT
GCTGTACCTCATTTTTAGGAGGTGTGCATGGATGCAATATATGAAAATGGGACATTCTGGAACTGCTGGTCAGGGGACTTTGTCGCCCTG
TGCACTAAAAGGGCCAGATTTTCAGCAGCCAAGGACATCCATACCCAAGTGAATGTGATGGGACTTAAAAGAAGTGAACTGAGACAATTC
ACTCTGGCTGTTTGAACAGCAGCGTTTCATAGGAAGAGAAAAAAAGATCAATCTTGTATTTTCTGACCACATAAAGGCTTCTTCTCTTTG

>55425_55425_1_MSRB3-CNOT2_MSRB3_chr12_65672645_ENST00000355192_CNOT2_chr12_70729218_ENST00000229195_length(amino acids)=361AA_BP=37
MPGLSMSPRRTLPRPLSLCLSLCLCLCLAAALGSAQSDGSENVTGLDLSDFPALADRNRREGSGNPTPLINPLAGRAPYVGMVTKPANEQ
SQDFSIHNEDFPALPGSSYKDPTSSNDDSKSNLNTSGKTTSSTDGPKFPGDKSSTTQNNNQQKKGIQVLPDGRVTNIPQGMVTDQFGMIG
LLTFIRAAETDPGMVHLALGSDLTTLGLNLNSPENLYPKFASPWASSPCRPQDIDFHVPSEYLTNIHIRDKLAAIKLGRYGEDLLFYLYY
MNGGDVLQLLAAVELFNRDWRYHKEERVWITRAPGMEPTMKTNTYERGTYYFFDCLNWRKVAKEFHLEYDKLEERPHLPSTFNYNPAQQA

--------------------------------------------------------------
>55425_55425_2_MSRB3-CNOT2_MSRB3_chr12_65672645_ENST00000355192_CNOT2_chr12_70729218_ENST00000418359_length(transcript)=2275nt_BP=223nt
ATATTTGGACTCGGCTGCCCGTGCCCAGGAATTTCCCGTCATGCCTCCCGCCGCCCCGTCCGTCGCCCGGAGCCGGGGAGGGAGGGAGCG
AGGTTCGGACACCGGCGGCGGCTGCCTGGCCTTTCCATGAGCCCGCGGCGGACCCTCCCGCGCCCCCTCTCGCTCTGCCTCTCCCTCTGC
CTCTGCCTCTGCCTGGCCGCGGCTCTGGGAAGTGCGCAGTCCGACGGAAGTGAAAATGTGACAGGATTGGACCTTTCAGATTTCCCAGCA
TTAGCAGACCGAAACAGGAGGGAAGGAAGTGGTAACCCAACTCCATTAATAAACCCCTTGGCTGGAAGAGCTCCTTATGTTGGAATGGTA
ACAAAACCAGCAAATGAACAATCCCAGGACTTCTCAATACACAATGAAGATTTTCCAGCATTACCAGGCTCCAGCTATAAAGATCCAACA
TCAAGTAATGATGACAGTAAATCTAATTTGAATACATCTGGCAAGACAACTTCAAGTACAGATGGACCCAAATTCCCTGGAGATAAAAGT
TCAACAACACAAAATAATAACCAGCAGAAAAAAGGGATCCAGGTGTTACCTGATGGTCGGGTTACTAACATTCCTCAAGGGATGGTGACG
GACCAATTTGGAATGATTGGCCTGTTAACATTTATCAGGGCAGCAGAGACAGACCCAGGAATGGTACATCTTGCATTAGGAAGTGACTTA
ACAACATTAGGCCTCAATCTGAACTCTCCTGAAAATCTCTACCCCAAATTTGCGTCACCCTGGGCATCTTCACCTTGTCGACCTCAAGAC
ATAGACTTCCATGTTCCATCTGAGTACTTAACGAACATTCACATTAGGGATAAGCTGGCTGCAATAAAACTTGGCCGATATGGTGAAGAC
CTTCTCTTCTATCTCTATTACATGAATGGAGGAGACGTATTACAACTTTTAGCTGCAGTGGAGCTTTTTAACCGTGATTGGAGATACCAC
AAAGAAGAACGAGTATGGATTACCAGGGCACCAGGCATGGAGCCAACAATGAAAACCAATACCTATGAGAGGGGAACATATTACTTCTTT
GACTGTCTTAACTGGAGGAAAGTAGCTAAGGAGTTCCATCTGGAATATGACAAATTAGAAGAACGGCCTCACCTGCCATCCACCTTCAAC
TACAACCCTGCTCAGCAAGCCTTCTAAAAAAAAAAAAAAAAAAAAAAAAAGACTTCCCTTTTCTTGGGGTATGGCTGTCTCAGCACAATA
CTCAACATAACTGCAGAACTGATGTGGCTCAGGCACCCTGGTTTTAATTCCTTGAGGATCTGGCAATTGGCTTACGCAAAAGGTCACCAT
TTGAGGTCCTGCCTTACTAATTATGTGCTGCCCAACAACTAAATTTGTAATTTGTTTTTCTCTAGTTTGAGCAGGGTCTGAATTTTTTCA
TTTATTTCCTTTTTTGCCAGCAGACAGACTTGAGTCTGTAAAGACAAGCAAATACACTGACAGAAGTTTACCATAGTTTCTAAAATGTAA
AAAAGAAAACCCCCAAAAGACTCAAGAAAATTAGACCACAAATTTTGCATTGTTCATTGTAGCACTATTGGTAATAAAATAACAAATGTT
TGTGCATTTTTATGTGAAGATCCTTCTCGTATTTCATTTGGAAAGATGAGCAAGAGGTCTGCTTCCTTCATTTTACTTCCCCTTCTGTTT
TTGAAAGGCAGTTTCGCCAAGCTTAATGCAAGAATATCTGACTGTTTAGAAGAAAGATATTGCCACAATCTCTGGATGGTTTTCCAGGGT
TGTGTTATTACTGAGCTTCATCTTTCCAGAATGAGCAAAACACTGTCCAGTCTTTGTTACGATTTTGTAATAAATGTGTACATTTTTTTT
AAATTTTTGGACATCACATGAATAAAGGTATGTATGTACGAATGTGTATATATTATATATATGACATCTATTTTGGAAAATGTTTGCCCT
GCTGTACCTCATTTTTAGGAGGTGTGCATGGATGCAATATATGAAAATGGGACATTCTGGAACTGCTGGTCAGGGGACTTTGTCGCCCTG
TGCACTAAAAGGGCCAGATTTTCAGCAGCCAAGGACATCCATACCCAAGTGAATGTGATGGGACTTAAAAGAAGTGAACTGAGACAATTC
ACTCTGGCTGTTTGAACAGCAGCGTTTCATAGGAAGAGAAAAAAAGATCAATCTTGTATTTTCTGACCACATAAAGGCTTCTTCTCTTTG

>55425_55425_2_MSRB3-CNOT2_MSRB3_chr12_65672645_ENST00000355192_CNOT2_chr12_70729218_ENST00000418359_length(amino acids)=361AA_BP=37
MPGLSMSPRRTLPRPLSLCLSLCLCLCLAAALGSAQSDGSENVTGLDLSDFPALADRNRREGSGNPTPLINPLAGRAPYVGMVTKPANEQ
SQDFSIHNEDFPALPGSSYKDPTSSNDDSKSNLNTSGKTTSSTDGPKFPGDKSSTTQNNNQQKKGIQVLPDGRVTNIPQGMVTDQFGMIG
LLTFIRAAETDPGMVHLALGSDLTTLGLNLNSPENLYPKFASPWASSPCRPQDIDFHVPSEYLTNIHIRDKLAAIKLGRYGEDLLFYLYY
MNGGDVLQLLAAVELFNRDWRYHKEERVWITRAPGMEPTMKTNTYERGTYYFFDCLNWRKVAKEFHLEYDKLEERPHLPSTFNYNPAQQA

--------------------------------------------------------------
>55425_55425_3_MSRB3-CNOT2_MSRB3_chr12_65672645_ENST00000540804_CNOT2_chr12_70729218_ENST00000229195_length(transcript)=2186nt_BP=134nt
GAGGTTCGGACACCGGCGGCGGCTGCCTGGCCTTTCCATGAGCCCGCGGCGGACCCTCCCGCGCCCCCTCTCGCTCTGCCTCTCCCTCTG
CCTCTGCCTCTGCCTGGCCGCGGCTCTGGGAAGTGCGCAGTCCGACGGAAGTGAAAATGTGACAGGATTGGACCTTTCAGATTTCCCAGC
ATTAGCAGACCGAAACAGGAGGGAAGGAAGTGGTAACCCAACTCCATTAATAAACCCCTTGGCTGGAAGAGCTCCTTATGTTGGAATGGT
AACAAAACCAGCAAATGAACAATCCCAGGACTTCTCAATACACAATGAAGATTTTCCAGCATTACCAGGCTCCAGCTATAAAGATCCAAC
ATCAAGTAATGATGACAGTAAATCTAATTTGAATACATCTGGCAAGACAACTTCAAGTACAGATGGACCCAAATTCCCTGGAGATAAAAG
TTCAACAACACAAAATAATAACCAGCAGAAAAAAGGGATCCAGGTGTTACCTGATGGTCGGGTTACTAACATTCCTCAAGGGATGGTGAC
GGACCAATTTGGAATGATTGGCCTGTTAACATTTATCAGGGCAGCAGAGACAGACCCAGGAATGGTACATCTTGCATTAGGAAGTGACTT
AACAACATTAGGCCTCAATCTGAACTCTCCTGAAAATCTCTACCCCAAATTTGCGTCACCCTGGGCATCTTCACCTTGTCGACCTCAAGA
CATAGACTTCCATGTTCCATCTGAGTACTTAACGAACATTCACATTAGGGATAAGCTGGCTGCAATAAAACTTGGCCGATATGGTGAAGA
CCTTCTCTTCTATCTCTATTACATGAATGGAGGAGACGTATTACAACTTTTAGCTGCAGTGGAGCTTTTTAACCGTGATTGGAGATACCA
CAAAGAAGAACGAGTATGGATTACCAGGGCACCAGGCATGGAGCCAACAATGAAAACCAATACCTATGAGAGGGGAACATATTACTTCTT
TGACTGTCTTAACTGGAGGAAAGTAGCTAAGGAGTTCCATCTGGAATATGACAAATTAGAAGAACGGCCTCACCTGCCATCCACCTTCAA
CTACAACCCTGCTCAGCAAGCCTTCTAAAAAAAAAAAAAAAAAAAAAAAAAGACTTCCCTTTTCTTGGGGTATGGCTGTCTCAGCACAAT
ACTCAACATAACTGCAGAACTGATGTGGCTCAGGCACCCTGGTTTTAATTCCTTGAGGATCTGGCAATTGGCTTACGCAAAAGGTCACCA
TTTGAGGTCCTGCCTTACTAATTATGTGCTGCCCAACAACTAAATTTGTAATTTGTTTTTCTCTAGTTTGAGCAGGGTCTGAATTTTTTC
ATTTATTTCCTTTTTTGCCAGCAGACAGACTTGAGTCTGTAAAGACAAGCAAATACACTGACAGAAGTTTACCATAGTTTCTAAAATGTA
AAAAAGAAAACCCCCAAAAGACTCAAGAAAATTAGACCACAAATTTTGCATTGTTCATTGTAGCACTATTGGTAATAAAATAACAAATGT
TTGTGCATTTTTATGTGAAGATCCTTCTCGTATTTCATTTGGAAAGATGAGCAAGAGGTCTGCTTCCTTCATTTTACTTCCCCTTCTGTT
TTTGAAAGGCAGTTTCGCCAAGCTTAATGCAAGAATATCTGACTGTTTAGAAGAAAGATATTGCCACAATCTCTGGATGGTTTTCCAGGG
TTGTGTTATTACTGAGCTTCATCTTTCCAGAATGAGCAAAACACTGTCCAGTCTTTGTTACGATTTTGTAATAAATGTGTACATTTTTTT
TAAATTTTTGGACATCACATGAATAAAGGTATGTATGTACGAATGTGTATATATTATATATATGACATCTATTTTGGAAAATGTTTGCCC
TGCTGTACCTCATTTTTAGGAGGTGTGCATGGATGCAATATATGAAAATGGGACATTCTGGAACTGCTGGTCAGGGGACTTTGTCGCCCT
GTGCACTAAAAGGGCCAGATTTTCAGCAGCCAAGGACATCCATACCCAAGTGAATGTGATGGGACTTAAAAGAAGTGAACTGAGACAATT
CACTCTGGCTGTTTGAACAGCAGCGTTTCATAGGAAGAGAAAAAAAGATCAATCTTGTATTTTCTGACCACATAAAGGCTTCTTCTCTTT

>55425_55425_3_MSRB3-CNOT2_MSRB3_chr12_65672645_ENST00000540804_CNOT2_chr12_70729218_ENST00000229195_length(amino acids)=361AA_BP=37
MPGLSMSPRRTLPRPLSLCLSLCLCLCLAAALGSAQSDGSENVTGLDLSDFPALADRNRREGSGNPTPLINPLAGRAPYVGMVTKPANEQ
SQDFSIHNEDFPALPGSSYKDPTSSNDDSKSNLNTSGKTTSSTDGPKFPGDKSSTTQNNNQQKKGIQVLPDGRVTNIPQGMVTDQFGMIG
LLTFIRAAETDPGMVHLALGSDLTTLGLNLNSPENLYPKFASPWASSPCRPQDIDFHVPSEYLTNIHIRDKLAAIKLGRYGEDLLFYLYY
MNGGDVLQLLAAVELFNRDWRYHKEERVWITRAPGMEPTMKTNTYERGTYYFFDCLNWRKVAKEFHLEYDKLEERPHLPSTFNYNPAQQA

--------------------------------------------------------------
>55425_55425_4_MSRB3-CNOT2_MSRB3_chr12_65672645_ENST00000540804_CNOT2_chr12_70729218_ENST00000418359_length(transcript)=2186nt_BP=134nt
GAGGTTCGGACACCGGCGGCGGCTGCCTGGCCTTTCCATGAGCCCGCGGCGGACCCTCCCGCGCCCCCTCTCGCTCTGCCTCTCCCTCTG
CCTCTGCCTCTGCCTGGCCGCGGCTCTGGGAAGTGCGCAGTCCGACGGAAGTGAAAATGTGACAGGATTGGACCTTTCAGATTTCCCAGC
ATTAGCAGACCGAAACAGGAGGGAAGGAAGTGGTAACCCAACTCCATTAATAAACCCCTTGGCTGGAAGAGCTCCTTATGTTGGAATGGT
AACAAAACCAGCAAATGAACAATCCCAGGACTTCTCAATACACAATGAAGATTTTCCAGCATTACCAGGCTCCAGCTATAAAGATCCAAC
ATCAAGTAATGATGACAGTAAATCTAATTTGAATACATCTGGCAAGACAACTTCAAGTACAGATGGACCCAAATTCCCTGGAGATAAAAG
TTCAACAACACAAAATAATAACCAGCAGAAAAAAGGGATCCAGGTGTTACCTGATGGTCGGGTTACTAACATTCCTCAAGGGATGGTGAC
GGACCAATTTGGAATGATTGGCCTGTTAACATTTATCAGGGCAGCAGAGACAGACCCAGGAATGGTACATCTTGCATTAGGAAGTGACTT
AACAACATTAGGCCTCAATCTGAACTCTCCTGAAAATCTCTACCCCAAATTTGCGTCACCCTGGGCATCTTCACCTTGTCGACCTCAAGA
CATAGACTTCCATGTTCCATCTGAGTACTTAACGAACATTCACATTAGGGATAAGCTGGCTGCAATAAAACTTGGCCGATATGGTGAAGA
CCTTCTCTTCTATCTCTATTACATGAATGGAGGAGACGTATTACAACTTTTAGCTGCAGTGGAGCTTTTTAACCGTGATTGGAGATACCA
CAAAGAAGAACGAGTATGGATTACCAGGGCACCAGGCATGGAGCCAACAATGAAAACCAATACCTATGAGAGGGGAACATATTACTTCTT
TGACTGTCTTAACTGGAGGAAAGTAGCTAAGGAGTTCCATCTGGAATATGACAAATTAGAAGAACGGCCTCACCTGCCATCCACCTTCAA
CTACAACCCTGCTCAGCAAGCCTTCTAAAAAAAAAAAAAAAAAAAAAAAAAGACTTCCCTTTTCTTGGGGTATGGCTGTCTCAGCACAAT
ACTCAACATAACTGCAGAACTGATGTGGCTCAGGCACCCTGGTTTTAATTCCTTGAGGATCTGGCAATTGGCTTACGCAAAAGGTCACCA
TTTGAGGTCCTGCCTTACTAATTATGTGCTGCCCAACAACTAAATTTGTAATTTGTTTTTCTCTAGTTTGAGCAGGGTCTGAATTTTTTC
ATTTATTTCCTTTTTTGCCAGCAGACAGACTTGAGTCTGTAAAGACAAGCAAATACACTGACAGAAGTTTACCATAGTTTCTAAAATGTA
AAAAAGAAAACCCCCAAAAGACTCAAGAAAATTAGACCACAAATTTTGCATTGTTCATTGTAGCACTATTGGTAATAAAATAACAAATGT
TTGTGCATTTTTATGTGAAGATCCTTCTCGTATTTCATTTGGAAAGATGAGCAAGAGGTCTGCTTCCTTCATTTTACTTCCCCTTCTGTT
TTTGAAAGGCAGTTTCGCCAAGCTTAATGCAAGAATATCTGACTGTTTAGAAGAAAGATATTGCCACAATCTCTGGATGGTTTTCCAGGG
TTGTGTTATTACTGAGCTTCATCTTTCCAGAATGAGCAAAACACTGTCCAGTCTTTGTTACGATTTTGTAATAAATGTGTACATTTTTTT
TAAATTTTTGGACATCACATGAATAAAGGTATGTATGTACGAATGTGTATATATTATATATATGACATCTATTTTGGAAAATGTTTGCCC
TGCTGTACCTCATTTTTAGGAGGTGTGCATGGATGCAATATATGAAAATGGGACATTCTGGAACTGCTGGTCAGGGGACTTTGTCGCCCT
GTGCACTAAAAGGGCCAGATTTTCAGCAGCCAAGGACATCCATACCCAAGTGAATGTGATGGGACTTAAAAGAAGTGAACTGAGACAATT
CACTCTGGCTGTTTGAACAGCAGCGTTTCATAGGAAGAGAAAAAAAGATCAATCTTGTATTTTCTGACCACATAAAGGCTTCTTCTCTTT

>55425_55425_4_MSRB3-CNOT2_MSRB3_chr12_65672645_ENST00000540804_CNOT2_chr12_70729218_ENST00000418359_length(amino acids)=361AA_BP=37
MPGLSMSPRRTLPRPLSLCLSLCLCLCLAAALGSAQSDGSENVTGLDLSDFPALADRNRREGSGNPTPLINPLAGRAPYVGMVTKPANEQ
SQDFSIHNEDFPALPGSSYKDPTSSNDDSKSNLNTSGKTTSSTDGPKFPGDKSSTTQNNNQQKKGIQVLPDGRVTNIPQGMVTDQFGMIG
LLTFIRAAETDPGMVHLALGSDLTTLGLNLNSPENLYPKFASPWASSPCRPQDIDFHVPSEYLTNIHIRDKLAAIKLGRYGEDLLFYLYY
MNGGDVLQLLAAVELFNRDWRYHKEERVWITRAPGMEPTMKTNTYERGTYYFFDCLNWRKVAKEFHLEYDKLEERPHLPSTFNYNPAQQA

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for MSRB3-CNOT2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for MSRB3-CNOT2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for MSRB3-CNOT2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneMSRB3C3711374Nonsyndromic Deafness3CLINGEN
HgeneMSRB3C1384666hearing impairment2CTD_human;GENOMICS_ENGLAND
HgeneMSRB3C2239351DEAFNESS, AUTOSOMAL RECESSIVE 742CTD_human;GENOMICS_ENGLAND;UNIPROT