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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:NAALADL2-AMACR (FusionGDB2 ID:HG254827TG23600)

Fusion Gene Summary for NAALADL2-AMACR

Fusion gene summary

Fusion gene information	Fusion gene name: NAALADL2-AMACR
	Fusion gene ID: hg254827tg23600
		Hgene	Tgene
	Gene symbol	NAALADL2	AMACR
	Gene ID	254827	23600
	Gene name	N-acetylated alpha-linked acidic dipeptidase like 2	alpha-methylacyl-CoA racemase
	Synonyms	-	AMACRD\|CBAS4\|P504S\|RACE\|RM
	Cytomap	('NAALADL2')('AMACR') 3q26.31	5p13.2
	Type of gene	protein-coding	protein-coding
	Description	inactive N-acetylated-alpha-linked acidic dipeptidase-like protein 2N-acetylated alpha-linked acidic dipeptidase 2NAALADase L2glutamate carboxypeptidase II-type non-peptidase homologue	alpha-methylacyl-CoA racemase2-methylacyl-CoA racemase
	Modification date	20200313	20200313
	UniProtAcc	Q58DX5	Q9UHK6
	Ensembl transtripts involved in fusion gene	ENST00000473253, ENST00000454872,
Fusion gene scores	* DoF score	28 X 19 X 9=4788	28 X 3 X 4=336
	# samples	29	23
	** MAII score	log2(29/4788*10)=-4.04529834692857 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(23/336*10)=-0.546827371834385 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: NAALADL2 [Title/Abstract] AND AMACR [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	NAALADL2(175042114)-AMACR(34006004), # samples:1
Anticipated loss of major functional domain due to fusion event.	NAALADL2-AMACR seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. NAALADL2-AMACR seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. NAALADL2-AMACR seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. NAALADL2-AMACR seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	AMACR	GO:0008206	bile acid metabolic process	10655068

Fusion gene breakpoints across NAALADL2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across AMACR (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	PRAD	TCGA-YL-A8SC	NAALADL2	chr3	175042114	+	AMACR	chr5	34006004	-

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Fusion Gene ORF analysis for NAALADL2-AMACR

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
3UTR-3CDS	ENST00000473253	ENST00000335606	NAALADL2	chr3	175042114	+	AMACR	chr5	34006004	-
3UTR-3CDS	ENST00000473253	ENST00000382072	NAALADL2	chr3	175042114	+	AMACR	chr5	34006004	-
3UTR-5UTR	ENST00000473253	ENST00000382068	NAALADL2	chr3	175042114	+	AMACR	chr5	34006004	-
3UTR-5UTR	ENST00000473253	ENST00000382085	NAALADL2	chr3	175042114	+	AMACR	chr5	34006004	-
3UTR-5UTR	ENST00000473253	ENST00000426255	NAALADL2	chr3	175042114	+	AMACR	chr5	34006004	-
3UTR-5UTR	ENST00000473253	ENST00000441713	NAALADL2	chr3	175042114	+	AMACR	chr5	34006004	-
3UTR-5UTR	ENST00000473253	ENST00000502637	NAALADL2	chr3	175042114	+	AMACR	chr5	34006004	-
3UTR-5UTR	ENST00000473253	ENST00000512079	NAALADL2	chr3	175042114	+	AMACR	chr5	34006004	-
3UTR-5UTR	ENST00000473253	ENST00000514195	NAALADL2	chr3	175042114	+	AMACR	chr5	34006004	-
5CDS-5UTR	ENST00000454872	ENST00000382068	NAALADL2	chr3	175042114	+	AMACR	chr5	34006004	-
5CDS-5UTR	ENST00000454872	ENST00000382085	NAALADL2	chr3	175042114	+	AMACR	chr5	34006004	-
5CDS-5UTR	ENST00000454872	ENST00000426255	NAALADL2	chr3	175042114	+	AMACR	chr5	34006004	-
5CDS-5UTR	ENST00000454872	ENST00000441713	NAALADL2	chr3	175042114	+	AMACR	chr5	34006004	-
5CDS-5UTR	ENST00000454872	ENST00000502637	NAALADL2	chr3	175042114	+	AMACR	chr5	34006004	-
5CDS-5UTR	ENST00000454872	ENST00000512079	NAALADL2	chr3	175042114	+	AMACR	chr5	34006004	-
5CDS-5UTR	ENST00000454872	ENST00000514195	NAALADL2	chr3	175042114	+	AMACR	chr5	34006004	-
In-frame	ENST00000454872	ENST00000335606	NAALADL2	chr3	175042114	+	AMACR	chr5	34006004	-
In-frame	ENST00000454872	ENST00000382072	NAALADL2	chr3	175042114	+	AMACR	chr5	34006004	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000454872

NAALADL2

chr3

175042114

ENST00000335606

AMACR

chr5

34006004

5035

1218

128

2119

663

ENST00000454872

NAALADL2

chr3

175042114

ENST00000382072

AMACR

chr5

34006004

3878

1218

128

1567

479

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000454872	ENST00000335606	NAALADL2	chr3	175042114	+	AMACR	chr5	34006004	-	0.000190484	0.99980956
ENST00000454872	ENST00000382072	NAALADL2	chr3	175042114	+	AMACR	chr5	34006004	-	0.000300507	0.9996995

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Fusion Genomic Features for NAALADL2-AMACR

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

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Fusion Protein Features for NAALADL2-AMACR

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:175042114/chr5:34006004)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
NAALADL2 Q58DX5	AMACR Q9UHK6
FUNCTION: May be catalytically inactive.	FUNCTION: Catalyzes the interconversion of (R)- and (S)-stereoisomers of alpha-methyl-branched-chain fatty acyl-CoA esters (PubMed:7649182, PubMed:10655068, PubMed:11060359). Acts only on coenzyme A thioesters, not on free fatty acids, and accepts as substrates a wide range of alpha-methylacyl-CoAs, including pristanoyl-CoA, trihydroxycoprostanoyl-CoA (an intermediate in bile acid synthesis), and arylpropionic acids like the anti-inflammatory drug ibuprofen (2-(4-isobutylphenyl)propionic acid) but neither 3-methyl-branched nor linear-chain acyl-CoAs (PubMed:7649182, PubMed:10655068, PubMed:11060359). {ECO:0000269\|PubMed:10655068, ECO:0000269\|PubMed:11060359, ECO:0000269\|PubMed:7649182}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

NAALADL2

chr3:175042114

chr5:34006004

ENST00000454872

1_121

363

796.0

Topological domain

Cytoplasmic

Hgene

NAALADL2

chr3:175042114

chr5:34006004

ENST00000454872

122_142

363

796.0

Transmembrane

Helical%3B Signal-anchor for type II membrane protein

Tgene

AMACR

chr3:175042114

chr5:34006004

ENST00000335606

380_382

383.0

Motif

Microbody targeting signal

Tgene

AMACR

chr3:175042114

chr5:34006004

ENST00000382072

380_382

199.0

Motif

Microbody targeting signal

Tgene

AMACR

chr3:175042114

chr5:34006004

ENST00000382085

380_382

395.0

Motif

Microbody targeting signal

Tgene

AMACR

chr3:175042114

chr5:34006004

ENST00000441713

380_382

230.0

Motif

Microbody targeting signal

Tgene

AMACR

chr3:175042114

chr5:34006004

ENST00000335606

121_126

383.0

Region

Substrate binding

Tgene

AMACR

chr3:175042114

chr5:34006004

ENST00000382072

121_126

199.0

Region

Substrate binding

Tgene

AMACR

chr3:175042114

chr5:34006004

ENST00000382085

121_126

395.0

Region

Substrate binding

Tgene

AMACR

chr3:175042114

chr5:34006004

ENST00000441713

121_126

230.0

Region

Substrate binding

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

NAALADL2

chr3:175042114

chr5:34006004

ENST00000454872

143_795

363

796.0

Topological domain

Extracellular

Tgene

AMACR

chr3:175042114

chr5:34006004

ENST00000335606

55_58

383.0

Region

Substrate binding

Tgene

AMACR

chr3:175042114

chr5:34006004

ENST00000382072

55_58

199.0

Region

Substrate binding

Tgene

AMACR

chr3:175042114

chr5:34006004

ENST00000382085

55_58

395.0

Region

Substrate binding

Tgene

AMACR

chr3:175042114

chr5:34006004

ENST00000441713

55_58

230.0

Region

Substrate binding

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Fusion Gene Sequence for NAALADL2-AMACR

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>57023_57023_1_NAALADL2-AMACR_NAALADL2_chr3_175042114_ENST00000454872_AMACR_chr5_34006004_ENST00000335606_length(transcript)=5035nt_BP=1218nt
TTATTCACAGAAGAAAGCAGGTAGTATACTGTTACAATACTACAGTAGAAAGTCAGAAGGTCACAAAGCTTGCAGGGTAAGTGACACAAC
TTGAAACTGCTTGGCCCTCTTTAAAAAGAAATAATAAAATGGGAGAGAATGAAGCAAGTTTACCTAACACGTCTTTGCAAGGTAAAAAGA
TGGCCTATCAGAAGGTCCATGCAGATCAAAGAGCTCCAGGACACTCACAGTACTTAGACAATGATGACCTTCAAGCCACTGCCCTTGACT
TAGAGTGGGACATGGAGAAGGAACTAGAGGAGTCTGGTTTTGACCAATTCCAGCTAGACGGTGCTGAGAATCAGAACCTAGGGCATTCAG
AGACTATAGACCTCAATCTTGATTCCATTCAACCAGCAACTTCACCCAAAGGAAGGTTCCAGAGACTTCAAGAAGAATCTGACTACATTA
CCCATTATACACGATCTGCACCAAAGAGCAATCGCTGCAACTTTTGCCACGTCTTAAAAATACTTTGCACAGCCACCATTTTATTTATTT
TTGGGATTTTGATAGGTTATTATGTACATACAAATTGCCCTTCAGATGCTCCATCTTCAGGAACAGTTGATCCTCAGTTATATCAAGAGA
TTCTCAAGACAATCCAGGCAGAAGATATTAAGAAGTCTTTCAGAAATTTGGTACAACTATATAAAAATGAAGATGACATGGAAATTTCAA
AGAAGATTAAGACTCAGTGGACCTCTTTGGGCCTAGAAGATGTACAGTTTGTAAATTACTCTGTGCTGCTTGATCTGCCAGGCCCTTCTC
CCAGCACTGTGACTCTGAGCAGCAGTGGTCAATGCTTTCATCCTAATGGCCAGCCTTGCAGTGAAGAAGCCAGAAAAGATAGCAGCCAAG
ACCTGCTCTATTCATATGCAGCCTATTCTGCCAAAGGAACTCTCAAGGCTGAAGTCATCGATGTGAGTTATGGAATGGCAGATGATTTAA
AAAGGATTAGGAAAATAAAAAACGTAACAAATCAGATCGCACTCCTGAAATTAGGAAAATTGCCACTGCTTTATAAGCTTTCCTCATTGG
AAAAGGCTGGATTTGGAGGTGTTCTTCTGTATATCGATCCTTGTGATTTGCCAAAGACTGTGAATCCTAGCCATGATACCTTCATGGTGT
CACTGAATCCAGGAGGAGACCCTTCTACGCCTGGTTACCCAAGTGTCGGTGTCATGGAGAAACTCCAGCTGGGCCCAGAGATTCTGCAGC
GGGAAAATCCAAGGCTTATTTATGCCAGGCTGAGTGGATTTGGCCAGTCAGGAAGCTTCTGCCGGTTAGCTGGCCACGATATCAACTATT
TGGCTTTGTCAGGTGTTCTCTCAAAAATTGGCAGAAGTGGTGAGAATCCGTATGCCCCGCTGAATCTCCTGGCTGACTTTGCTGGTGGTG
GCCTTATGTGTGCACTGGGCATTATAATGGCTCTTTTTGACCGCACACGCACTGGCAAGGGTCAGGTCATTGATGCAAATATGGTGGAAG
GAACAGCATATTTAAGTTCTTTTCTGTGGAAAACTCAGAAATTGAGTCTGTGGGAAGCACCTCGAGGACAGAACATGTTGGATGGTGGAG
CACCTTTCTATACGACTTACAGGACAGCAGATGGGGAATTCATGGCTGTTGGAGCAATAGAACCCCAGTTCTACGAGCTGCTGATCAAAG
GACTTGGACTAAAGTCTGATGAACTTCCCAATCAGATGAGCATGGATGATTGGCCAGAAATGAAGAAGAAGTTTGCAGATGTATTTGCAG
AGAAGACGAAGGCAGAGTGGTGTCAAATCTTTGACGGCACAGATGCCTGTGTGACTCCGGTTCTGACTTTTGAGGAGGTTGTTCATCATG
ATCACAACAAGGAACGGGGCTCGTTTATCACCAGTGAGGAGCAGGACGTGAGCCCCCGCCCTGCACCTCTGCTGTTAAACACCCCAGCCA
TCCCTTCTTTCAAAAGGGATCCTTTCATAGGAGAACACACTGAGGAGATACTTGAAGAATTTGGATTCAGCCGCGAAGAGATTTATCAGC
TTAACTCAGATAAAATCATTGAAAGTAATAAGGTAAAAGCTAGTCTCTAACTTCCAGGCCCACGGCTCAAGTGAATTTGAATACTGCATT
TACAGTGTAGAGTAACACATAACATTGTATGCATGGAAACATGGAGGAACAGTATTACAGTGTCCTACCACTCTAATCAAGAAAAGAATT
ACAGACTCTGATTCTACAGTGATGATTGAATTCTAAAAATGGTTATCATTAGGGCTTTTGATTTATAAAACTTTGGGTACTTATACTAAA
TTATGGTAGTTATTCTGCCTTCCAGTTTGCTTGATATATTTGTTGATATTAAGATTCTTGACTTATATTTTGAATGGGTTCTAGTGAAAA
AGGAATGATATATTCTTGAAGACATCGATATACATTTATTTACACTCTTGATTCTACAATGTAGAAAATGAGGAAATGCCACAAATTGTA
TGGTGATAAAAGTCACGTGAAACAGAGTGATTGGTTGCATCCAGGCCTTTTGTCTTGGTGTTCATGATCTCCCTCTAAGCACATTCCAAA
CTTTAGCAACAGTTATCACACTTTGTAATTTGCAAAGAAAAGTTTCACCTGTATTGAATCAGAATGCCTTCAACTGAAAAAAACATATCC
AAAATAATGAGGAAATGTGTTGGCTCACTACGTAGAGTCCAGAGGGACAGTCAGTTTTAGGGTTGCCTGTATCCAGTAACTCGGGGCCTG
TTTCCCCGTGGGTCTCTGGGCTGTCAGCTTTCCTTTCTCCATGTGTTTGATTTCTCCTCAGGCTGGTAGCAAGTTCTGGATCTTATACCC
AACACACAGCAACATCCAGAAATAAAGATCTCAGGACCCCCCAGCAAGTCGTTTTGTGTCTCCTTGGACTGAGTTAAGTTACAAGCCTTT
CTTATACCTGTCTTTGACAAAGAAGACGGGATTGTCTTTACATAAAACCAGCCTGCTCCTGGAGCTTCCCTGGACTCAACTTCCTAAAGG
CATGTGAGGAAGGGGTAGATTCCACAATCTAATCCGGGTGCCATCAGAGTAGAGGGAGTAGAGAATGGATGTTGGGTAGGCCATCAATAA
GGTCCATTCTGCGCAGTATCTCAACTGCCGTTCAACAATCGCAAGAGGAAGGTGGAGCAGGTTTCTTCATCTTACAGTTGAGAAAACAGA
GACTCAGAAGGGCTTCTTAGTTCATGTTTCCCTTAGCGCCTCAGTGATTTTTTCATGGTGGCTTAGGCCAAAAGAAATATCTAACCATTC
AATTTATAAATAATTAGGTCCCCAACGAATTAAATATTATGTCCTACCAACTTATTAGCTGCTTGAAAAATATAATACACATAAATAAAA
AAATATATTTTTCATTTCTATTTCATTGTTAATCACAACTACTTACTAAGGAGATGTATGCACCTATTGGACACTGTGCAACTTCTCACC
TGGAATGAGATTGGACACTGCTGCCCTCATTTTCTGCTCCATGTTGGTGTCCATATAGTACTTGATTTTTTATCAGATGGCCTGGAAAAC
CCAGTCTCACAAAAATATGAAATTATCAGAAGGATTATAGTGCAATCTTATGTTGAAAGAATGAACTACCTCACTAGTAGTTCACGTGAT
GTCTGACAGATGTTGAGTTTCATTGTGTTTGTGTGTTCAAATTTTTAAATATTCTGAGATACTCTTGTGAGGTCACTCTAATGCCCTGGG
TGCCTTGGCACAGTTTTAGAAATACCAGTTGAAAATATTTGCTCAGGAATATGCAACTAGGAAGGGGCAGAATCAGAATTTAAGCTTTCA
TATTCTAGCCTTCAGTCTTGTTCTTCAACCATTTTTAGGAACTTTCCCATAAGGTTATGTTTTCCAGCCCAGGCATGGAGGATCACTTGA
GGCCAAGAGTTCGAGACCAGCCTGGGGAACTTGGCTGGACCTCCGTTTCTACGAAATAAAAATAAAAAAATTATCCAGGTATGGTGGTGT
GTGCCTGTAGTCCTATCTACTCAAGGGTGGGGCAGGAGGATCACTTGAGCCCAGGAATTTGAGGCCACAGTGAATTAGGATTGCACCACT
GCACTCTAGCCCAGGCAACAGAACAAGAACCTGTCTCTAAATAAATAAATAAAAATAATAATAATAAAAAAGATGTTTTCCCTACAACTC
AGACTTTTCATTTGAACTCGGTCCAGCAAGGAAAATATAACCCACTCGAAGTCTTTAAAACAGAGGAAATTTAATATAAAGAATTCCACT
GGTGACGAAAGAGCAGAGAAGCCCAGAAGATAGTGAGGCAACCCTGATAGGAACATAACTAGGAAGCCAAGACCACTCCTATGGTTGCAG
GGGTGATGGGAAAGCTGGTGTACTTGGACCCAGAAGCCAAAGTTGCTGCACCCACCTTGGAGACATAGACACTGGCAGTAATACCTCAGG
GAGAAGAAAGAAATCTAGGGAAATATCCTGGCTTCTTTCCTTCTCTCTCTCCCCTAGTCTTCCTACCAGTGTCTCCCATTAGCCAAATCT
ACCTAGAAGCCAGAAAACAAGGGAACCCTGGAAATGTAGCCCCATAAGATAAAGAGCACCAAAGGAAATAGATCTGAGCAGACAGGCAGC
ACAAAATGCAGTGTGTATGGTTTATTCACTCAGTAATTCCTTTAGCAAATGTTTATTGAGGATCTACTAGGTGCCAGGTATCATGATACT
TGCTGGGGATACCATAATGAACAAAACAGACCTGTTCTCCGCTCTTGAGGAAATCAAAGACAAACACAGGATATGGAATAAACCCAGAAT
TATCTCATTGTAAAATGTGTTAAGTACCACGAGGAGAAATATCAGGGCGATCTGACACAGCTAATGATTTGAAGAAGGGTGTGACCTGCC

>57023_57023_1_NAALADL2-AMACR_NAALADL2_chr3_175042114_ENST00000454872_AMACR_chr5_34006004_ENST00000335606_length(amino acids)=663AA_BP=361
MGENEASLPNTSLQGKKMAYQKVHADQRAPGHSQYLDNDDLQATALDLEWDMEKELEESGFDQFQLDGAENQNLGHSETIDLNLDSIQPA
TSPKGRFQRLQEESDYITHYTRSAPKSNRCNFCHVLKILCTATILFIFGILIGYYVHTNCPSDAPSSGTVDPQLYQEILKTIQAEDIKKS
FRNLVQLYKNEDDMEISKKIKTQWTSLGLEDVQFVNYSVLLDLPGPSPSTVTLSSSGQCFHPNGQPCSEEARKDSSQDLLYSYAAYSAKG
TLKAEVIDVSYGMADDLKRIRKIKNVTNQIALLKLGKLPLLYKLSSLEKAGFGGVLLYIDPCDLPKTVNPSHDTFMVSLNPGGDPSTPGY
PSVGVMEKLQLGPEILQRENPRLIYARLSGFGQSGSFCRLAGHDINYLALSGVLSKIGRSGENPYAPLNLLADFAGGGLMCALGIIMALF
DRTRTGKGQVIDANMVEGTAYLSSFLWKTQKLSLWEAPRGQNMLDGGAPFYTTYRTADGEFMAVGAIEPQFYELLIKGLGLKSDELPNQM
SMDDWPEMKKKFADVFAEKTKAEWCQIFDGTDACVTPVLTFEEVVHHDHNKERGSFITSEEQDVSPRPAPLLLNTPAIPSFKRDPFIGEH

--------------------------------------------------------------
>57023_57023_2_NAALADL2-AMACR_NAALADL2_chr3_175042114_ENST00000454872_AMACR_chr5_34006004_ENST00000382072_length(transcript)=3878nt_BP=1218nt
TTATTCACAGAAGAAAGCAGGTAGTATACTGTTACAATACTACAGTAGAAAGTCAGAAGGTCACAAAGCTTGCAGGGTAAGTGACACAAC
TTGAAACTGCTTGGCCCTCTTTAAAAAGAAATAATAAAATGGGAGAGAATGAAGCAAGTTTACCTAACACGTCTTTGCAAGGTAAAAAGA
TGGCCTATCAGAAGGTCCATGCAGATCAAAGAGCTCCAGGACACTCACAGTACTTAGACAATGATGACCTTCAAGCCACTGCCCTTGACT
TAGAGTGGGACATGGAGAAGGAACTAGAGGAGTCTGGTTTTGACCAATTCCAGCTAGACGGTGCTGAGAATCAGAACCTAGGGCATTCAG
AGACTATAGACCTCAATCTTGATTCCATTCAACCAGCAACTTCACCCAAAGGAAGGTTCCAGAGACTTCAAGAAGAATCTGACTACATTA
CCCATTATACACGATCTGCACCAAAGAGCAATCGCTGCAACTTTTGCCACGTCTTAAAAATACTTTGCACAGCCACCATTTTATTTATTT
TTGGGATTTTGATAGGTTATTATGTACATACAAATTGCCCTTCAGATGCTCCATCTTCAGGAACAGTTGATCCTCAGTTATATCAAGAGA
TTCTCAAGACAATCCAGGCAGAAGATATTAAGAAGTCTTTCAGAAATTTGGTACAACTATATAAAAATGAAGATGACATGGAAATTTCAA
AGAAGATTAAGACTCAGTGGACCTCTTTGGGCCTAGAAGATGTACAGTTTGTAAATTACTCTGTGCTGCTTGATCTGCCAGGCCCTTCTC
CCAGCACTGTGACTCTGAGCAGCAGTGGTCAATGCTTTCATCCTAATGGCCAGCCTTGCAGTGAAGAAGCCAGAAAAGATAGCAGCCAAG
ACCTGCTCTATTCATATGCAGCCTATTCTGCCAAAGGAACTCTCAAGGCTGAAGTCATCGATGTGAGTTATGGAATGGCAGATGATTTAA
AAAGGATTAGGAAAATAAAAAACGTAACAAATCAGATCGCACTCCTGAAATTAGGAAAATTGCCACTGCTTTATAAGCTTTCCTCATTGG
AAAAGGCTGGATTTGGAGGTGTTCTTCTGTATATCGATCCTTGTGATTTGCCAAAGACTGTGAATCCTAGCCATGATACCTTCATGGTGT
CACTGAATCCAGGAGGAGACCCTTCTACGCCTGGTTACCCAAGTGTCGGTGTCATGGAGAAACTCCAGCTGGGCCCAGAGATTCTGCAGC
GGGAAAATCCAAGGCTTATTTATGCCAGGCTGAGTGGATTTGGCCAGTCAGGAAGCTTCTGCCGGTTAGCTGGCCACGATATCAACTATT
TGGCTTTGTCAGGTGGAAGGAACAGCATATTTAAGTTCTTTTCTGTGGAAAACTCAGAAATTGAGTCTGTGGGAAGCACCTCGAGGACAG
AACATGTTGGATGGTGGAGCACCTTTCTATACGACTTACAGGACAGCAGATGGGGAATTCATGGCTGTTGGAGCAATAGAACCCCAGTTC
TACGAGCTGCTGATCAAAGGACTTGGACTAAAGTCTGATGAACTTCCCAATCAGATGAGCATGGATGATTGGCCAGAAATGAAGAAGAAG
TTTGCAGATGTATTTGCAGAGAAGACGAAGGCAGAGTGGTGTCAAATCTTTGACGGCACAGATGCCTGTGTGACTCCGGTTCTGACTTTT
GAGGAGGTTGTTCATCATGATCACAACAAGGAACGGGGCTCGTTTATCACCAGTGAGGAGCAGGACGTGAGCCCCCGCCCTGCACCTCTG
CTGTTAAACACCCCAGCCATCCCTTCTTTCAAAAGGGATCCTTTCATAGGAGAACACACTGAGGAGATACTTGAAGAATTTGGATTCAGC
CGCGAAGAGATTTATCAGCTTAACTCAGATAAAATCATTGAAAGTAATAAGGTAAAAGCTAGTCTCTAACTTCCAGGCCCACGGCTCAAG
TGAATTTGAATACTGCATTTACAGTGTAGAGTAACACATAACATTGTATGCATGGAAACATGGAGGAACAGTATTACAGTGTCCTACCAC
TCTAATCAAGAAAAGAATTACAGACTCTGATTCTACAGTGATGATTGAATTCTAAAAATGGTTATCATTAGGGCTTTTGATTTATAAAAC
TTTGGGTACTTATACTAAATTATGGTAGTTATTCTGCCTTCCAGTTTGCTTGATATATTTGTTGATATTAAGATTCTTGACTTATATTTT
GAATGGGTTCTAGTGAAAAAGGAATGATATATTCTTGAAGACATCGATATACATTTATTTACACTCTTGATTCTACAATGTAGAAAATGA
GGAAATGCCACAAATTGTATGGTGATAAAAGTCACGTGAAACAGAGTGATTGGTTGCATCCAGGCCTTTTGTCTTGGTGTTCATGATCTC
CCTCTAAGCACATTCCAAACTTTAGCAACAGTTATCACACTTTGTAATTTGCAAAGAAAAGTTTCACCTGTATTGAATCAGAATGCCTTC
AACTGAAAAAAACATATCCAAAATAATGAGGAAATGTGTTGGCTCACTACGTAGAGTCCAGAGGGACAGTCAGTTTTAGGGTTGCCTGTA
TCCAGTAACTCGGGGCCTGTTTCCCCGTGGGTCTCTGGGCTGTCAGCTTTCCTTTCTCCATGTGTTTGATTTCTCCTCAGGCTGGTAGCA
AGTTCTGGATCTTATACCCAACACACAGCAACATCCAGAAATAAAGATCTCAGGACCCCCCAGCAAGTCGTTTTGTGTCTCCTTGGACTG
AGTTAAGTTACAAGCCTTTCTTATACCTGTCTTTGACAAAGAAGACGGGATTGTCTTTACATAAAACCAGCCTGCTCCTGGAGCTTCCCT
GGACTCAACTTCCTAAAGGCATGTGAGGAAGGGGTAGATTCCACAATCTAATCCGGGTGCCATCAGAGTAGAGGGAGTAGAGAATGGATG
TTGGGTAGGCCATCAATAAGGTCCATTCTGCGCAGTATCTCAACTGCCGTTCAACAATCGCAAGAGGAAGGTGGAGCAGGTTTCTTCATC
TTACAGTTGAGAAAACAGAGACTCAGAAGGGCTTCTTAGTTCATGTTTCCCTTAGCGCCTCAGTGATTTTTTCATGGTGGCTTAGGCCAA
AAGAAATATCTAACCATTCAATTTATAAATAATTAGGTCCCCAACGAATTAAATATTATGTCCTACCAACTTATTAGCTGCTTGAAAAAT
ATAATACACATAAATAAAAAAATATATTTTTCATTTCTATTTCATTGTTAATCACAACTACTTACTAAGGAGATGTATGCACCTATTGGA
CACTGTGCAACTTCTCACCTGGAATGAGATTGGACACTGCTGCCCTCATTTTCTGCTCCATGTTGGTGTCCATATAGTACTTGATTTTTT
ATCAGATGGCCTGGAAAACCCAGTCTCACAAAAATATGAAATTATCAGAAGGATTATAGTGCAATCTTATGTTGAAAGAATGAACTACCT
CACTAGTAGTTCACGTGATGTCTGACAGATGTTGAGTTTCATTGTGTTTGTGTGTTCAAATTTTTAAATATTCTGAGATACTCTTGTGAG
GTCACTCTAATGCCCTGGGTGCCTTGGCACAGTTTTAGAAATACCAGTTGAAAATATTTGCTCAGGAATATGCAACTAGGAAGGGGCAGA
ATCAGAATTTAAGCTTTCATATTCTAGCCTTCAGTCTTGTTCTTCAACCATTTTTAGGAACTTTCCCATAAGGTTATGTTTTCCAGCCCA
GGCATGGAGGATCACTTGAGGCCAAGAGTTCGAGACCAGCCTGGGGAACTTGGCTGGACCTCCGTTTCTACGAAATAAAAATAAAAAAAT

>57023_57023_2_NAALADL2-AMACR_NAALADL2_chr3_175042114_ENST00000454872_AMACR_chr5_34006004_ENST00000382072_length(amino acids)=479AA_BP=361
MGENEASLPNTSLQGKKMAYQKVHADQRAPGHSQYLDNDDLQATALDLEWDMEKELEESGFDQFQLDGAENQNLGHSETIDLNLDSIQPA
TSPKGRFQRLQEESDYITHYTRSAPKSNRCNFCHVLKILCTATILFIFGILIGYYVHTNCPSDAPSSGTVDPQLYQEILKTIQAEDIKKS
FRNLVQLYKNEDDMEISKKIKTQWTSLGLEDVQFVNYSVLLDLPGPSPSTVTLSSSGQCFHPNGQPCSEEARKDSSQDLLYSYAAYSAKG
TLKAEVIDVSYGMADDLKRIRKIKNVTNQIALLKLGKLPLLYKLSSLEKAGFGGVLLYIDPCDLPKTVNPSHDTFMVSLNPGGDPSTPGY
PSVGVMEKLQLGPEILQRENPRLIYARLSGFGQSGSFCRLAGHDINYLALSGGRNSIFKFFSVENSEIESVGSTSRTEHVGWWSTFLYDL

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Fusion Gene PPI Analysis for NAALADL2-AMACR

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for NAALADL2-AMACR

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for NAALADL2-AMACR

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Tgene		C0033578	Prostatic Neoplasms	3	CTD_human
Tgene		C0376358	Malignant neoplasm of prostate	3	CTD_human
Tgene		C1858328	Bile acid synthesis defect, congenital, 4	3	CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
Tgene		C3280428	Alpha-Methylacyl-CoA Racemase Deficiency	3	CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
Tgene		C0023893	Liver Cirrhosis, Experimental	2	CTD_human
Tgene		C0001430	Adenoma	1	CTD_human
Tgene		C0009402	Colorectal Carcinoma	1	CTD_human
Tgene		C0009404	Colorectal Neoplasms	1	CTD_human
Tgene		C0011195	Dejerine-Sottas Disease (disorder)	1	CTD_human
Tgene		C0019816	Hereditary, Type VII, Motor and Sensory Neuropathy	1	CTD_human
Tgene		C0023895	Liver diseases	1	CTD_human
Tgene		C0027888	Hereditary Motor and Sensory Neuropathies	1	CTD_human
Tgene		C0036341	Schizophrenia	1	PSYGENET
Tgene		C0086565	Liver Dysfunction	1	CTD_human
Tgene		C0205646	Adenoma, Basal Cell	1	CTD_human
Tgene		C0205647	Follicular adenoma	1	CTD_human
Tgene		C0205648	Adenoma, Microcystic	1	CTD_human
Tgene		C0205649	Adenoma, Monomorphic	1	CTD_human
Tgene		C0205650	Papillary adenoma	1	CTD_human
Tgene		C0205651	Adenoma, Trabecular	1	CTD_human

Fusion Gene Studies in Kim Lab

Fusion gene:NAALADL2-AMACR (FusionGDB2 ID:HG254827TG23600)

Fusion Gene Summary for NAALADL2-AMACR

Fusion Gene ORF analysis for NAALADL2-AMACR

Fusion Genomic Features for NAALADL2-AMACR

Fusion Protein Features for NAALADL2-AMACR

Fusion Gene Sequence for NAALADL2-AMACR

Fusion Gene PPI Analysis for NAALADL2-AMACR

Related Drugs for NAALADL2-AMACR

Related Diseases for NAALADL2-AMACR

Fusion Gene Studies
in Kim Lab