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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:GABPB1-CSNK1G3 (FusionGDB2 ID:HG2553TG1456)

Fusion Gene Summary for GABPB1-CSNK1G3

check button Fusion gene summary
Fusion gene informationFusion gene name: GABPB1-CSNK1G3
Fusion gene ID: hg2553tg1456
HgeneTgene
Gene symbol

GABPB1

CSNK1G3

Gene ID

2553

1456

Gene nameGA binding protein transcription factor subunit beta 1casein kinase 1 gamma 3
SynonymsBABPB2|E4TF1|E4TF1-47|E4TF1-53|E4TF1B|GABPB|GABPB-1|GABPB2|NRF2B1|NRF2B2CKI-gamma 3|CSNK1G3L
Cytomap('GABPB1')('CSNK1G3')

15q21.2

5q23.2

Type of geneprotein-codingprotein-coding
DescriptionGA-binding protein subunit beta-1GA binding protein transcription factor beta subunit 1 transcript variant gamma-2GABP subunit beta-2nuclear respiratory factor 2transcription factor E4TF1-47transcription factor E4TF1-53casein kinase I isoform gamma-3casein kinase I
Modification date2020031320200313
UniProtAcc.

Q9Y6M4

Ensembl transtripts involved in fusion geneENST00000220429, ENST00000359031, 
ENST00000380877, ENST00000396464, 
ENST00000429662, ENST00000543881, 
ENST00000560825, 
Fusion gene scores* DoF score8 X 5 X 6=2407 X 7 X 5=245
# samples 99
** MAII scorelog2(9/240*10)=-1.41503749927884
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(9/245*10)=-1.4447848426729
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: GABPB1 [Title/Abstract] AND CSNK1G3 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointGABPB1(50647182)-CSNK1G3(122881111), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneGABPB1

GO:0045944

positive regulation of transcription by RNA polymerase II

9857059

TgeneCSNK1G3

GO:0018105

peptidyl-serine phosphorylation

25500533



check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4PRADTCGA-G9-6348-01AGABPB1chr15

50647182

-CSNK1G3chr5

122881111

+


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Fusion Gene ORF analysis for GABPB1-CSNK1G3

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3UTRENST00000220429ENST00000508708GABPB1chr15

50647182

-CSNK1G3chr5

122881111

+
5UTR-3UTRENST00000359031ENST00000508708GABPB1chr15

50647182

-CSNK1G3chr5

122881111

+
5UTR-3UTRENST00000380877ENST00000508708GABPB1chr15

50647182

-CSNK1G3chr5

122881111

+
5UTR-3UTRENST00000396464ENST00000508708GABPB1chr15

50647182

-CSNK1G3chr5

122881111

+
5UTR-3UTRENST00000429662ENST00000508708GABPB1chr15

50647182

-CSNK1G3chr5

122881111

+
5UTR-3UTRENST00000543881ENST00000508708GABPB1chr15

50647182

-CSNK1G3chr5

122881111

+
5UTR-3UTRENST00000560825ENST00000508708GABPB1chr15

50647182

-CSNK1G3chr5

122881111

+
5UTR-5UTRENST00000220429ENST00000345990GABPB1chr15

50647182

-CSNK1G3chr5

122881111

+
5UTR-5UTRENST00000220429ENST00000395411GABPB1chr15

50647182

-CSNK1G3chr5

122881111

+
5UTR-5UTRENST00000220429ENST00000395412GABPB1chr15

50647182

-CSNK1G3chr5

122881111

+
5UTR-5UTRENST00000359031ENST00000345990GABPB1chr15

50647182

-CSNK1G3chr5

122881111

+
5UTR-5UTRENST00000359031ENST00000395411GABPB1chr15

50647182

-CSNK1G3chr5

122881111

+
5UTR-5UTRENST00000359031ENST00000395412GABPB1chr15

50647182

-CSNK1G3chr5

122881111

+
5UTR-5UTRENST00000380877ENST00000345990GABPB1chr15

50647182

-CSNK1G3chr5

122881111

+
5UTR-5UTRENST00000380877ENST00000395411GABPB1chr15

50647182

-CSNK1G3chr5

122881111

+
5UTR-5UTRENST00000380877ENST00000395412GABPB1chr15

50647182

-CSNK1G3chr5

122881111

+
5UTR-5UTRENST00000396464ENST00000345990GABPB1chr15

50647182

-CSNK1G3chr5

122881111

+
5UTR-5UTRENST00000396464ENST00000395411GABPB1chr15

50647182

-CSNK1G3chr5

122881111

+
5UTR-5UTRENST00000396464ENST00000395412GABPB1chr15

50647182

-CSNK1G3chr5

122881111

+
5UTR-5UTRENST00000429662ENST00000345990GABPB1chr15

50647182

-CSNK1G3chr5

122881111

+
5UTR-5UTRENST00000429662ENST00000395411GABPB1chr15

50647182

-CSNK1G3chr5

122881111

+
5UTR-5UTRENST00000429662ENST00000395412GABPB1chr15

50647182

-CSNK1G3chr5

122881111

+
5UTR-5UTRENST00000543881ENST00000345990GABPB1chr15

50647182

-CSNK1G3chr5

122881111

+
5UTR-5UTRENST00000543881ENST00000395411GABPB1chr15

50647182

-CSNK1G3chr5

122881111

+
5UTR-5UTRENST00000543881ENST00000395412GABPB1chr15

50647182

-CSNK1G3chr5

122881111

+
5UTR-5UTRENST00000560825ENST00000345990GABPB1chr15

50647182

-CSNK1G3chr5

122881111

+
5UTR-5UTRENST00000560825ENST00000395411GABPB1chr15

50647182

-CSNK1G3chr5

122881111

+
5UTR-5UTRENST00000560825ENST00000395412GABPB1chr15

50647182

-CSNK1G3chr5

122881111

+
5UTR-intronENST00000220429ENST00000360683GABPB1chr15

50647182

-CSNK1G3chr5

122881111

+
5UTR-intronENST00000220429ENST00000361991GABPB1chr15

50647182

-CSNK1G3chr5

122881111

+
5UTR-intronENST00000220429ENST00000510842GABPB1chr15

50647182

-CSNK1G3chr5

122881111

+
5UTR-intronENST00000220429ENST00000511130GABPB1chr15

50647182

-CSNK1G3chr5

122881111

+
5UTR-intronENST00000220429ENST00000512718GABPB1chr15

50647182

-CSNK1G3chr5

122881111

+
5UTR-intronENST00000220429ENST00000521364GABPB1chr15

50647182

-CSNK1G3chr5

122881111

+
5UTR-intronENST00000359031ENST00000360683GABPB1chr15

50647182

-CSNK1G3chr5

122881111

+
5UTR-intronENST00000359031ENST00000361991GABPB1chr15

50647182

-CSNK1G3chr5

122881111

+
5UTR-intronENST00000359031ENST00000510842GABPB1chr15

50647182

-CSNK1G3chr5

122881111

+
5UTR-intronENST00000359031ENST00000511130GABPB1chr15

50647182

-CSNK1G3chr5

122881111

+
5UTR-intronENST00000359031ENST00000512718GABPB1chr15

50647182

-CSNK1G3chr5

122881111

+
5UTR-intronENST00000359031ENST00000521364GABPB1chr15

50647182

-CSNK1G3chr5

122881111

+
5UTR-intronENST00000380877ENST00000360683GABPB1chr15

50647182

-CSNK1G3chr5

122881111

+
5UTR-intronENST00000380877ENST00000361991GABPB1chr15

50647182

-CSNK1G3chr5

122881111

+
5UTR-intronENST00000380877ENST00000510842GABPB1chr15

50647182

-CSNK1G3chr5

122881111

+
5UTR-intronENST00000380877ENST00000511130GABPB1chr15

50647182

-CSNK1G3chr5

122881111

+
5UTR-intronENST00000380877ENST00000512718GABPB1chr15

50647182

-CSNK1G3chr5

122881111

+
5UTR-intronENST00000380877ENST00000521364GABPB1chr15

50647182

-CSNK1G3chr5

122881111

+
5UTR-intronENST00000396464ENST00000360683GABPB1chr15

50647182

-CSNK1G3chr5

122881111

+
5UTR-intronENST00000396464ENST00000361991GABPB1chr15

50647182

-CSNK1G3chr5

122881111

+
5UTR-intronENST00000396464ENST00000510842GABPB1chr15

50647182

-CSNK1G3chr5

122881111

+
5UTR-intronENST00000396464ENST00000511130GABPB1chr15

50647182

-CSNK1G3chr5

122881111

+
5UTR-intronENST00000396464ENST00000512718GABPB1chr15

50647182

-CSNK1G3chr5

122881111

+
5UTR-intronENST00000396464ENST00000521364GABPB1chr15

50647182

-CSNK1G3chr5

122881111

+
5UTR-intronENST00000429662ENST00000360683GABPB1chr15

50647182

-CSNK1G3chr5

122881111

+
5UTR-intronENST00000429662ENST00000361991GABPB1chr15

50647182

-CSNK1G3chr5

122881111

+
5UTR-intronENST00000429662ENST00000510842GABPB1chr15

50647182

-CSNK1G3chr5

122881111

+
5UTR-intronENST00000429662ENST00000511130GABPB1chr15

50647182

-CSNK1G3chr5

122881111

+
5UTR-intronENST00000429662ENST00000512718GABPB1chr15

50647182

-CSNK1G3chr5

122881111

+
5UTR-intronENST00000429662ENST00000521364GABPB1chr15

50647182

-CSNK1G3chr5

122881111

+
5UTR-intronENST00000543881ENST00000360683GABPB1chr15

50647182

-CSNK1G3chr5

122881111

+
5UTR-intronENST00000543881ENST00000361991GABPB1chr15

50647182

-CSNK1G3chr5

122881111

+
5UTR-intronENST00000543881ENST00000510842GABPB1chr15

50647182

-CSNK1G3chr5

122881111

+
5UTR-intronENST00000543881ENST00000511130GABPB1chr15

50647182

-CSNK1G3chr5

122881111

+
5UTR-intronENST00000543881ENST00000512718GABPB1chr15

50647182

-CSNK1G3chr5

122881111

+
5UTR-intronENST00000543881ENST00000521364GABPB1chr15

50647182

-CSNK1G3chr5

122881111

+
5UTR-intronENST00000560825ENST00000360683GABPB1chr15

50647182

-CSNK1G3chr5

122881111

+
5UTR-intronENST00000560825ENST00000361991GABPB1chr15

50647182

-CSNK1G3chr5

122881111

+
5UTR-intronENST00000560825ENST00000510842GABPB1chr15

50647182

-CSNK1G3chr5

122881111

+
5UTR-intronENST00000560825ENST00000511130GABPB1chr15

50647182

-CSNK1G3chr5

122881111

+
5UTR-intronENST00000560825ENST00000512718GABPB1chr15

50647182

-CSNK1G3chr5

122881111

+
5UTR-intronENST00000560825ENST00000521364GABPB1chr15

50647182

-CSNK1G3chr5

122881111

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for GABPB1-CSNK1G3


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
GABPB1chr1550647181-CSNK1G3chr5122881108+0.000656910.9993431
GABPB1chr1550647181-CSNK1G3chr5122881108+0.000656910.9993431


check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for GABPB1-CSNK1G3


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:50647182/:122881111)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.CSNK1G3

Q9Y6M4

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Serine/threonine-protein kinase. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Regulates fast synaptic transmission mediated by glutamate (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for GABPB1-CSNK1G3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for GABPB1-CSNK1G3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for GABPB1-CSNK1G3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for GABPB1-CSNK1G3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource