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 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:GABRB3-FAF1 (FusionGDB2 ID:HG2562TG11124) |
Fusion Gene Summary for GABRB3-FAF1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: GABRB3-FAF1 | Fusion gene ID: hg2562tg11124 | Hgene | Tgene | Gene symbol | GABRB3 | FAF1 | Gene ID | 2562 | 11124 |
| Gene name | gamma-aminobutyric acid type A receptor subunit beta3 | Fas associated factor 1 | |
| Synonyms | ECA5|EIEE43 | CGI-03|HFAF1s|UBXD12|UBXN3A|hFAF1 | |
| Cytomap | ('GABRB3')('FAF1') 15q12 | 1p32.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | gamma-aminobutyric acid receptor subunit beta-3GABA-alpha receptor beta-2 subunitGABAA receptor beta-3 subunitgamma-aminobutyric acid (GABA) A receptor, beta 3gamma-aminobutyric acid A receptor beta 3gamma-aminobutyric acid type A receptor beta3 subu | FAS-associated factor 1Fas (TNFRSF6) associated factor 1TNFRSF6-associated factor 1UBX domain protein 3AUBX domain-containing protein 12UBX domain-containing protein 3A | |
| Modification date | 20200320 | 20200313 | |
| UniProtAcc | P28472 | . | |
| Ensembl transtripts involved in fusion gene | ENST00000299267, ENST00000311550, ENST00000541819, ENST00000557641, ENST00000400188, ENST00000545868, | ||
| Fusion gene scores | * DoF score | 9 X 9 X 2=162 | 28 X 23 X 14=9016 |
| # samples | 9 | 31 | |
| ** MAII score | log2(9/162*10)=-0.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(31/9016*10)=-4.86214739489798 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: GABRB3 [Title/Abstract] AND FAF1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | GABRB3(27017548)-FAF1(51323670), # samples:1 | ||
| Anticipated loss of major functional domain due to fusion event. | GABRB3-FAF1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. GABRB3-FAF1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. GABRB3-FAF1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. GABRB3-FAF1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | GABRB3 | GO:0071420 | cellular response to histamine | 18281286 |
| Hgene | GABRB3 | GO:1902476 | chloride transmembrane transport | 9039914 |
| Hgene | GABRB3 | GO:1904862 | inhibitory synapse assembly | 25489750 |
| Tgene | FAF1 | GO:0010942 | positive regulation of cell death | 15596450 |
| Fusion gene breakpoints across GABRB3 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene breakpoints across FAF1 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene information * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
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Fusion Gene ORF analysis for GABRB3-FAF1 |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000311550 | ENST00000396153 | GABRB3 | chr15 | 27017548 | - | FAF1 | chr1 | 51323670 | - | 0.00036881 | 0.99963117 |
| ENST00000311550 | ENST00000371778 | GABRB3 | chr15 | 27017548 | - | FAF1 | chr1 | 51323670 | - | 0.000781183 | 0.9992188 |
| ENST00000541819 | ENST00000396153 | GABRB3 | chr15 | 27017548 | - | FAF1 | chr1 | 51323670 | - | 0.000427758 | 0.9995722 |
| ENST00000541819 | ENST00000371778 | GABRB3 | chr15 | 27017548 | - | FAF1 | chr1 | 51323670 | - | 0.000899266 | 0.9991008 |
| ENST00000299267 | ENST00000396153 | GABRB3 | chr15 | 27017548 | - | FAF1 | chr1 | 51323670 | - | 0.000216905 | 0.9997831 |
| ENST00000299267 | ENST00000371778 | GABRB3 | chr15 | 27017548 | - | FAF1 | chr1 | 51323670 | - | 0.000527843 | 0.9994722 |
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Fusion Genomic Features for GABRB3-FAF1 |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
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Fusion Protein Features for GABRB3-FAF1 |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr15:27017548/chr1:51323670) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| GABRB3 | . |
| FUNCTION: Ligand-gated chloride channel which is a component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the brain (PubMed:18514161, PubMed:22303015, PubMed:26950270, PubMed:22243422, PubMed:24909990). Plays an important role in the formation of functional inhibitory GABAergic synapses in addition to mediating synaptic inhibition as a GABA-gated ion channel (PubMed:25489750). The gamma2 subunit is necessary but not sufficient for a rapid formation of active synaptic contacts and the synaptogenic effect of this subunit is influenced by the type of alpha and beta subunits present in the receptor pentamer (By similarity). The alpha1/beta3/gamma2 receptor exhibits synaptogenic activity (PubMed:25489750). The alpha2/beta3/gamma2 receptor shows very little or no synaptogenic activity (By similarity). Functions also as histamine receptor and mediates cellular responses to histamine (PubMed:18281286). Plays an important role in somatosensation and in the production of antinociception (By similarity). {ECO:0000250|UniProtKB:P63080, ECO:0000269|PubMed:18281286, ECO:0000269|PubMed:18514161, ECO:0000269|PubMed:22243422, ECO:0000269|PubMed:22303015, ECO:0000269|PubMed:24909990, ECO:0000269|PubMed:25489750, ECO:0000269|PubMed:26950270}. | FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | FAF1 | chr15:27017548 | chr1:51323670 | ENST00000371778 | 1 | 20 | 569_646 | 15 | 651.0 | Domain | UBX | |
| Tgene | FAF1 | chr15:27017548 | chr1:51323670 | ENST00000396153 | 0 | 19 | 569_646 | 15 | 651.0 | Domain | UBX |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | GABRB3 | chr15:27017548 | chr1:51323670 | ENST00000299267 | - | 3 | 9 | 120_122 | 80 | 474.0 | Region | Note=Agonist binding |
| Hgene | GABRB3 | chr15:27017548 | chr1:51323670 | ENST00000299267 | - | 3 | 9 | 180_182 | 80 | 474.0 | Region | Note=Agonist binding |
| Hgene | GABRB3 | chr15:27017548 | chr1:51323670 | ENST00000299267 | - | 3 | 9 | 290_311 | 80 | 474.0 | Region | Note=Allosteric effector binding |
| Hgene | GABRB3 | chr15:27017548 | chr1:51323670 | ENST00000311550 | - | 3 | 9 | 120_122 | 80 | 474.0 | Region | Note=Agonist binding |
| Hgene | GABRB3 | chr15:27017548 | chr1:51323670 | ENST00000311550 | - | 3 | 9 | 180_182 | 80 | 474.0 | Region | Note=Agonist binding |
| Hgene | GABRB3 | chr15:27017548 | chr1:51323670 | ENST00000311550 | - | 3 | 9 | 290_311 | 80 | 474.0 | Region | Note=Allosteric effector binding |
| Hgene | GABRB3 | chr15:27017548 | chr1:51323670 | ENST00000400188 | - | 1 | 7 | 120_122 | 0 | 403.0 | Region | Note=Agonist binding |
| Hgene | GABRB3 | chr15:27017548 | chr1:51323670 | ENST00000400188 | - | 1 | 7 | 180_182 | 0 | 403.0 | Region | Note=Agonist binding |
| Hgene | GABRB3 | chr15:27017548 | chr1:51323670 | ENST00000400188 | - | 1 | 7 | 290_311 | 0 | 403.0 | Region | Note=Allosteric effector binding |
| Hgene | GABRB3 | chr15:27017548 | chr1:51323670 | ENST00000545868 | - | 1 | 7 | 120_122 | 0 | 389.0 | Region | Note=Agonist binding |
| Hgene | GABRB3 | chr15:27017548 | chr1:51323670 | ENST00000545868 | - | 1 | 7 | 180_182 | 0 | 389.0 | Region | Note=Agonist binding |
| Hgene | GABRB3 | chr15:27017548 | chr1:51323670 | ENST00000545868 | - | 1 | 7 | 290_311 | 0 | 389.0 | Region | Note=Allosteric effector binding |
| Hgene | GABRB3 | chr15:27017548 | chr1:51323670 | ENST00000299267 | - | 3 | 9 | 268_270 | 80 | 474.0 | Topological domain | Cytoplasmic |
| Hgene | GABRB3 | chr15:27017548 | chr1:51323670 | ENST00000299267 | - | 3 | 9 | 26_245 | 80 | 474.0 | Topological domain | Extracellular |
| Hgene | GABRB3 | chr15:27017548 | chr1:51323670 | ENST00000299267 | - | 3 | 9 | 294_304 | 80 | 474.0 | Topological domain | Extracellular |
| Hgene | GABRB3 | chr15:27017548 | chr1:51323670 | ENST00000299267 | - | 3 | 9 | 328_450 | 80 | 474.0 | Topological domain | Cytoplasmic |
| Hgene | GABRB3 | chr15:27017548 | chr1:51323670 | ENST00000311550 | - | 3 | 9 | 268_270 | 80 | 474.0 | Topological domain | Cytoplasmic |
| Hgene | GABRB3 | chr15:27017548 | chr1:51323670 | ENST00000311550 | - | 3 | 9 | 26_245 | 80 | 474.0 | Topological domain | Extracellular |
| Hgene | GABRB3 | chr15:27017548 | chr1:51323670 | ENST00000311550 | - | 3 | 9 | 294_304 | 80 | 474.0 | Topological domain | Extracellular |
| Hgene | GABRB3 | chr15:27017548 | chr1:51323670 | ENST00000311550 | - | 3 | 9 | 328_450 | 80 | 474.0 | Topological domain | Cytoplasmic |
| Hgene | GABRB3 | chr15:27017548 | chr1:51323670 | ENST00000400188 | - | 1 | 7 | 268_270 | 0 | 403.0 | Topological domain | Cytoplasmic |
| Hgene | GABRB3 | chr15:27017548 | chr1:51323670 | ENST00000400188 | - | 1 | 7 | 26_245 | 0 | 403.0 | Topological domain | Extracellular |
| Hgene | GABRB3 | chr15:27017548 | chr1:51323670 | ENST00000400188 | - | 1 | 7 | 294_304 | 0 | 403.0 | Topological domain | Extracellular |
| Hgene | GABRB3 | chr15:27017548 | chr1:51323670 | ENST00000400188 | - | 1 | 7 | 328_450 | 0 | 403.0 | Topological domain | Cytoplasmic |
| Hgene | GABRB3 | chr15:27017548 | chr1:51323670 | ENST00000545868 | - | 1 | 7 | 268_270 | 0 | 389.0 | Topological domain | Cytoplasmic |
| Hgene | GABRB3 | chr15:27017548 | chr1:51323670 | ENST00000545868 | - | 1 | 7 | 26_245 | 0 | 389.0 | Topological domain | Extracellular |
| Hgene | GABRB3 | chr15:27017548 | chr1:51323670 | ENST00000545868 | - | 1 | 7 | 294_304 | 0 | 389.0 | Topological domain | Extracellular |
| Hgene | GABRB3 | chr15:27017548 | chr1:51323670 | ENST00000545868 | - | 1 | 7 | 328_450 | 0 | 389.0 | Topological domain | Cytoplasmic |
| Hgene | GABRB3 | chr15:27017548 | chr1:51323670 | ENST00000299267 | - | 3 | 9 | 246_267 | 80 | 474.0 | Transmembrane | Note=Helical |
| Hgene | GABRB3 | chr15:27017548 | chr1:51323670 | ENST00000299267 | - | 3 | 9 | 271_293 | 80 | 474.0 | Transmembrane | Note=Helical |
| Hgene | GABRB3 | chr15:27017548 | chr1:51323670 | ENST00000299267 | - | 3 | 9 | 305_327 | 80 | 474.0 | Transmembrane | Note=Helical |
| Hgene | GABRB3 | chr15:27017548 | chr1:51323670 | ENST00000299267 | - | 3 | 9 | 451_472 | 80 | 474.0 | Transmembrane | Note=Helical |
| Hgene | GABRB3 | chr15:27017548 | chr1:51323670 | ENST00000311550 | - | 3 | 9 | 246_267 | 80 | 474.0 | Transmembrane | Note=Helical |
| Hgene | GABRB3 | chr15:27017548 | chr1:51323670 | ENST00000311550 | - | 3 | 9 | 271_293 | 80 | 474.0 | Transmembrane | Note=Helical |
| Hgene | GABRB3 | chr15:27017548 | chr1:51323670 | ENST00000311550 | - | 3 | 9 | 305_327 | 80 | 474.0 | Transmembrane | Note=Helical |
| Hgene | GABRB3 | chr15:27017548 | chr1:51323670 | ENST00000311550 | - | 3 | 9 | 451_472 | 80 | 474.0 | Transmembrane | Note=Helical |
| Hgene | GABRB3 | chr15:27017548 | chr1:51323670 | ENST00000400188 | - | 1 | 7 | 246_267 | 0 | 403.0 | Transmembrane | Note=Helical |
| Hgene | GABRB3 | chr15:27017548 | chr1:51323670 | ENST00000400188 | - | 1 | 7 | 271_293 | 0 | 403.0 | Transmembrane | Note=Helical |
| Hgene | GABRB3 | chr15:27017548 | chr1:51323670 | ENST00000400188 | - | 1 | 7 | 305_327 | 0 | 403.0 | Transmembrane | Note=Helical |
| Hgene | GABRB3 | chr15:27017548 | chr1:51323670 | ENST00000400188 | - | 1 | 7 | 451_472 | 0 | 403.0 | Transmembrane | Note=Helical |
| Hgene | GABRB3 | chr15:27017548 | chr1:51323670 | ENST00000545868 | - | 1 | 7 | 246_267 | 0 | 389.0 | Transmembrane | Note=Helical |
| Hgene | GABRB3 | chr15:27017548 | chr1:51323670 | ENST00000545868 | - | 1 | 7 | 271_293 | 0 | 389.0 | Transmembrane | Note=Helical |
| Hgene | GABRB3 | chr15:27017548 | chr1:51323670 | ENST00000545868 | - | 1 | 7 | 305_327 | 0 | 389.0 | Transmembrane | Note=Helical |
| Hgene | GABRB3 | chr15:27017548 | chr1:51323670 | ENST00000545868 | - | 1 | 7 | 451_472 | 0 | 389.0 | Transmembrane | Note=Helical |
| Tgene | FAF1 | chr15:27017548 | chr1:51323670 | ENST00000371778 | 1 | 20 | 1_57 | 15 | 651.0 | Domain | UBA | |
| Tgene | FAF1 | chr15:27017548 | chr1:51323670 | ENST00000396153 | 0 | 19 | 1_57 | 15 | 651.0 | Domain | UBA |
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Fusion Gene Sequence for GABRB3-FAF1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >32119_32119_1_GABRB3-FAF1_GABRB3_chr15_27017548_ENST00000299267_FAF1_chr1_51323670_ENST00000371778_length(transcript)=2615nt_BP=304nt TTTGGCTGCTCGGAGAGTAGGGGGGAGAGCGGATCCCAGCAGGTTAGGCCGGAGGAACAGCGCCATGTGCTCCGGGCTCCTGGAGCTCCT GCTGCCCATCTGGCTCTCCTGGACCCTGGGGACCCGAGGCTCTGAGCCCCGCAGTGTGAACGATCCCGGGAACATGTCCTTTGTGAAGGA GACGGTGGACAAGCTGTTGAAAGGCTACGACATTCGCCTAAGACCCGACTTCGGGGGTCCCCCGGTCTGCGTGGGGATGAACATCGACAT CGCCAGCATCGACATGGTTTCCGAAGTCAACATGGCATGTACTGGCATTGAAAACATTGACGAAGCTATTACATTGCTTGAACAAAATAA TTGGGACTTAGTGGCAGCTATCAATGGTGTAATACCACAGGAAAATGGCATTCTACAAAGTGAATATGGAGGTGAGACCATACCAGGACC TGCATTTAATCCAGCAAGTCATCCAGCTTCAGCTCCTACTTCCTCTTCTTCTTCAGCGTTTCGACCTGTAATGCCATCCAGGCAGATTGT AGAAAGGCAACCTCGGATGCTGGACTTCAGGGTTGAATACAGAGACAGAAATGTTGATGTGGTACTTGAAGACACCTGTACTGTTGGAGA GATTAAACAGATTCTAGAAAATGAACTTCAGATACCTGTGTCCAAAATGCTGTTAAAAGGCTGGAAGACGGGAGATGTGGAAGACAGTAC GGTCCTAAAATCTCTACACTTGCCAAAAAACAACAGTCTTTATGTCCTTACACCAGATTTGCCACCACCTTCATCATCTAGTCATGCTGG TGCCCTGCAGGAGTCATTAAATCAAAACTTCATGCTGATCATCACCCACCGAGAAGTCCAGCGGGAGTACAACCTGAACTTCTCAGGAAG CAGTACTATTCAAGAGGTAAAGAGAAATGTGTATGACCTTACAAGTATCCCCGTTCGCCACCAATTATGGGAGGGCTGGCCAACTTCTGC TACAGACGACTCAATGTGTCTTGCTGAATCAGGGCTCTCTTATCCCTGCCATCGACTTACAGTGGGAAGAAGATCTTCACCTGCACAGAC CCGGGAACAGTCGGAAGAACAAATCACCGATGTTCATATGGTTAGTGATAGCGATGGAGATGACTTTGAAGATGCTACAGAATTTGGGGT GGATGATGGAGAAGTATTTGGCATGGCGTCATCTGCCTTGAGAAAATCTCCAATGATGCCAGAAAACGCAGAAAATGAAGGAGATGCCTT ATTACAATTTACAGCAGAGTTTTCTTCAAGATATGGTGATTGCCATCCTGTATTTTTTATTGGCTCATTAGAAGCTGCTTTTCAAGAGGC CTTCTATGTGAAAGCCCGAGATAGAAAGCTTCTTGCTATCTACCTCCACCATGATGAAAGTGTGTTAACCAACGTGTTCTGCTCACAAAT GCTTTGTGCTGAATCCATTGTTTCTTATCTGAGTCAAAATTTTATAACCTGGGCTTGGGATCTGACAAAGGACTCCAACAGAGCAAGATT TCTCACTATGTGCAATAGACACTTTGGCAGTGTTGTGGCACAAACCATTCGGACTCAAAAAACGGATCAGTTTCCGCTTTTCCTGATTAT TATGGGAAAGCGATCATCTAATGAAGTGTTGAATGTGATACAAGGGAACACAACAGTAGATGAGTTAATGATGAGACTCATGGCTGCAAT GGAGATCTTCACAGCCCAACAACAGGAAGATATAAAGGACGAGGATGAACGTGAAGCCAGAGAAAATGTGAAGAGAGAGCAAGATGAGGC CTATCGCCTTTCACTTGAGGCTGACAGAGCAAAGAGGGAAGCTCACGAGAGAGAGATGGCAGAACAGTTTCGTTTGGAGCAGATTCGCAA AGAACAAGAAGAGGAACGTGAGGCCATCCGGCTGTCCTTAGAGCAAGCCCTGCCTCCTGAGCCAAAGGAAGAAAATGCTGAGCCTGTGAG CAAACTGCGGATCCGGACCCCCAGTGGCGAGTTCTTGGAGCGGCGTTTCCTGGCCAGCAACAAGCTCCAGATTGTCTTTGATTTTGTAGC TTCCAAAGGATTTCCATGGGATGAGTACAAGTTACTGAGCACCTTTCCTAGGAGAGACGTAACTCAACTGGACCCAAATAAATCATTATT GGAGGTAAAGTTGTTCCCTCAAGAAACCCTTTTCCTTGAAGCAAAAGAGTAAACACGGCCCAGCGGTGGAACCAGCCATTCCTTGACAAG CCAGCAGCCTGCGTCAGGAGAAGGGCTCCTCGCCAACCCACCCACACGCTCGTCTCACTCAATTCAATGTCACACTTCTGCCTCTTGCAA AATTGCTGGAAAAAGTAATAATAAATATAGCTACTTAAGATTTCCCATCCATGAGTATATATTCCCAACCCTTATTACAGAGAATTACAA CTCTGCCACCCTCCCCTACCCCCTGCACTTCACCCTCCTTCAATGACGAATGCATTGTTCAAGTGTGAGTGATCACTAAATAGAATTTTT ACCTCTCCAGTGCCCATCTTTTCCCCACAGTGTCTAGGACAGTTCTGTCTGTTCTGTGACACCAGGATGCTGTATATTTGATATATGTCT >32119_32119_1_GABRB3-FAF1_GABRB3_chr15_27017548_ENST00000299267_FAF1_chr1_51323670_ENST00000371778_length(amino acids)=736AA_BP=101 LAARRVGGRADPSRLGRRNSAMCSGLLELLLPIWLSWTLGTRGSEPRSVNDPGNMSFVKETVDKLLKGYDIRLRPDFGGPPVCVGMNIDI ASIDMVSEVNMACTGIENIDEAITLLEQNNWDLVAAINGVIPQENGILQSEYGGETIPGPAFNPASHPASAPTSSSSSAFRPVMPSRQIV ERQPRMLDFRVEYRDRNVDVVLEDTCTVGEIKQILENELQIPVSKMLLKGWKTGDVEDSTVLKSLHLPKNNSLYVLTPDLPPPSSSSHAG ALQESLNQNFMLIITHREVQREYNLNFSGSSTIQEVKRNVYDLTSIPVRHQLWEGWPTSATDDSMCLAESGLSYPCHRLTVGRRSSPAQT REQSEEQITDVHMVSDSDGDDFEDATEFGVDDGEVFGMASSALRKSPMMPENAENEGDALLQFTAEFSSRYGDCHPVFFIGSLEAAFQEA FYVKARDRKLLAIYLHHDESVLTNVFCSQMLCAESIVSYLSQNFITWAWDLTKDSNRARFLTMCNRHFGSVVAQTIRTQKTDQFPLFLII MGKRSSNEVLNVIQGNTTVDELMMRLMAAMEIFTAQQQEDIKDEDEREARENVKREQDEAYRLSLEADRAKREAHEREMAEQFRLEQIRK EQEEEREAIRLSLEQALPPEPKEENAEPVSKLRIRTPSGEFLERRFLASNKLQIVFDFVASKGFPWDEYKLLSTFPRRDVTQLDPNKSLL -------------------------------------------------------------- >32119_32119_2_GABRB3-FAF1_GABRB3_chr15_27017548_ENST00000299267_FAF1_chr1_51323670_ENST00000396153_length(transcript)=4174nt_BP=304nt TTTGGCTGCTCGGAGAGTAGGGGGGAGAGCGGATCCCAGCAGGTTAGGCCGGAGGAACAGCGCCATGTGCTCCGGGCTCCTGGAGCTCCT GCTGCCCATCTGGCTCTCCTGGACCCTGGGGACCCGAGGCTCTGAGCCCCGCAGTGTGAACGATCCCGGGAACATGTCCTTTGTGAAGGA GACGGTGGACAAGCTGTTGAAAGGCTACGACATTCGCCTAAGACCCGACTTCGGGGGTCCCCCGGTCTGCGTGGGGATGAACATCGACAT CGCCAGCATCGACATGGTTTCCGAAGTCAACATGGCATGTACTGGCATTGAAAACATTGACGAAGCTATTACATTGCTTGAACAAAATAA TTGGGACTTAGTGGCAGCTATCAATGGTGTAATACCACAGGAAAATGGCATTCTACAAAGTGAATATGGAGGTGAGACCATACCAGGACC TGCATTTAATCCAGCAAGTCATCCAGCTTCAGCTCCTACTTCCTCTTCTTCTTCAGCGTTTCGACCTGTAATGCCATCCAGGCAGATTGT AGAAAGGCAACCTCGGATGCTGGACTTCAGGGTTGAATACAGAGACAGAAATGTTGATGTGGTACTTGAAGACACCTGTACTGTTGGAGA GATTAAACAGATTCTAGAAAATGAACTTCAGATACCTGTGTCCAAAATGCTGTTAAAAGGCTGGAAGACGGGAGATGTGGAAGACAGTAC GGTCCTAAAATCTCTACACTTGCCAAAAAACAACAGTCTTTATGTCCTTACACCAGATTTGCCACCACCTTCATCATCTAGTCATGCTGG TGCCCTGCAGGAGTCATTAAATCAAAACTTCATGCTGATCATCACCCACCGAGAAGTCCAGCGGGAGTACAACCTGAACTTCTCAGGAAG CAGTACTATTCAAGAGGTAAAGAGAAATGTGTATGACCTTACAAGTATCCCCGTTCGCCACCAATTATGGGAGGGCTGGCCAACTTCTGC TACAGACGACTCAATGTGTCTTGCTGAATCAGGGCTCTCTTATCCCTGCCATCGACTTACAGTGGGAAGAAGATCTTCACCTGCACAGAC CCGGGAACAGTCGGAAGAACAAATCACCGATGTTCATATGGTTAGTGATAGCGATGGAGATGACTTTGAAGATGCTACAGAATTTGGGGT GGATGATGGAGAAGTATTTGGCATGGCGTCATCTGCCTTGAGAAAATCTCCAATGATGCCAGAAAACGCAGAAAATGAAGGAGATGCCTT ATTACAATTTACAGCAGAGTTTTCTTCAAGATATGGTGATTGCCATCCTGTATTTTTTATTGGCTCATTAGAAGCTGCTTTTCAAGAGGC CTTCTATGTGAAAGCCCGAGATAGAAAGCTTCTTGCTATCTACCTCCACCATGATGAAAGTGTGTTAACCAACGTGTTCTGCTCACAAAT GCTTTGTGCTGAATCCATTGTTTCTTATCTGAGTCAAAATTTTATAACCTGGGCTTGGGATCTGACAAAGGACTCCAACAGAGCAAGATT TCTCACTATGTGCAATAGACACTTTGGCAGTGTTGTGGCACAAACCATTCGGACTCAAAAAACGGATCAGTTTCCGCTTTTCCTGATTAT TATGGGAAAGCGATCATCTAATGAAGTGTTGAATGTGATACAAGGGAACACAACAGTAGATGAGTTAATGATGAGACTCATGGCTGCAAT GGAGATCTTCACAGCCCAACAACAGGAAGATATAAAGGACGAGGATGAACGTGAAGCCAGAGAAAATGTGAAGAGAGAGCAAGATGAGGC CTATCGCCTTTCACTTGAGGCTGACAGAGCAAAGAGGGAAGCTCACGAGAGAGAGATGGCAGAACAGTTTCGTTTGGAGCAGATTCGCAA AGAACAAGAAGAGGAACGTGAGGCCATCCGGCTGTCCTTAGAGCAAGCCCTGCCTCCTGAGCCAAAGGAAGAAAATGCTGAGCCTGTGAG CAAACTGCGGATCCGGACCCCCAGTGGCGAGTTCTTGGAGCGGCGTTTCCTGGCCAGCAACAAGCTCCAGATTGTCTTTGATTTTGTAGC TTCCAAAGGATTTCCATGGGATGAGTACAAGTTACTGAGCACCTTTCCTAGGAGAGACGTAACTCAACTGGACCCAAATAAATCATTATT GGAGGTAAAGTTGTTCCCTCAAGAAACCCTTTTCCTTGAAGCAAAAGAGTAAACACGGCCCAGCGGTGGAACCAGCCATTCCTTGACAAG CCAGCAGCCTGCGTCAGGAGAAGGGCTCCTCGCCAACCCACCCACACGCTCGTCTCACTCAATTCAATGTCACACTTCTGCCTCTTGCAA AATTGCTGGAAAAAGTAATAATAAATATAGCTACTTAAGATTTCCCATCCATGAGTATATATTCCCAACCCTTATTACAGAGAATTACAA CTCTGCCACCCTCCCCTACCCCCTGCACTTCACCCTCCTTCAATGACGAATGCATTGTTCAAGTGTGAGTGATCACTAAATAGAATTTTT ACCTCTCCAGTGCCCATCTTTTCCCCACAGTGTCTAGGACAGTTCTGTCTGTTCTGTGACACCAGGATGCTGTATATTTGATATATGTCT TTTTATTTTCATGACTGAATTTCTACTTCATCACCTAATTTTAAGGGGCAGAGGGAAAAAAAGTCAAATGAGACATTGTCGGCATGGAGA TTAAACATTGTAGGAAAAAAGTATACCATTTTTGTTAGAACTTTCTGATGGCTTTACTAAGATGTCAGGTTTTGTTTGAGGACTGAATTT GACATATATGCAAGATATTTATTTACTGCTGCTGCCTTGGGTCTCCAGGTTCTACCTAGGAGGTATTTGCTGTTCCATTGCAGCATAGGG AAACTGTTCAAGCACACAATGTGAATGTTGAGATCATGTGCAGAGAGGCCAGTACCAAAACTTCAGTATCTGGCCCAATGGCAAGAGGCT ACTGTTAGGTTTGCATTTGGGCAGTTAGAACCTCACAGATACCAGCTCCCAAGTTGCTAGTCCATCAGTGTAAACTGAACACAATTCTCT CTTGCTTTCTCTCTCTCTACTCCCTCACACATTTGGACCTTGTCACTTGGTGTTTAAGCACCTTGCCTATCAACAAAATCTGATGAGCAG CCCCATGGACTCTCCTGTAATAAGGAACTTGCTCTACTATTTTATTCTTTTAATGTTTTAGTATTTGATATTGGACTCAAATGAAAGGGA TCTCATTCTGTGGCTGAAAAATCAGACTTCATATGTTGAAGAGAGCAAACTTGGGGACTCAACTCAGAAGACATGTGTTGCCTGAAACCT GCATATAATAATTTTTGATTTGATTTAGTAAGTGTGGATTTTTCTTAATCTACAGATTTGGGGTTTGGGGTTTAGATCATGAGAACACCG TTTATACCTTCACAGCCAATGATTTATTTTTAGTCTTGAAATATTTCTCCATATCTGTTTTTGTGTCACCTGTGGGTTTTATCCTAGGGG TTGGGATCCTGATTTTAACATTTTGTACTTGTCCAAAAAAGAGTTCAAATGCTGGGTTTGTTCCCCCAGCCTCGGCCAAGGGGTTCTCAG AAGATTCTAACCAAAGCTGGAGATAGGTCTGCTCATTTTCCTTCTGCCCAGAAGTGGATGTTGGCCAGGAAAATTACACCTTGTGTCTTC TCTGATGCTCCAACCAGGGACCTCTCCAGATTACTATCTAGCACAGACTAGTGCTACATCTGCCTAGGTATGGGCTTTCTCTGGCAGCAG GGGTCTCTCTAGGGAGGCTGAGAGACCCATGGGTCTCCCTTCAGGGGAAGTGTTCAGGGGAGTTCAAACTGAACACTTCTCTCCAGCTCT ATTCCTATCTTCCTAATCTAATGGCTCTACAAGATAGTCATTTCCAGTGCTACAGATGCACCAGGGCACCACCTCTTTTTTTTTCTAGGT AGACCTTGTTCTGTAGCTGCTGTGAAGAAGCTGCAGCCCTGAACTCAGGTCATACTCAGGAACAGCAGCAGGGGTGTGGGTGGGGTTTGA GGGAAGGTACTCTGAATTCACCTTCATGTTTAACCTGTTCCATCTGACTTGGGTTTCTTCATTATATTGTTCCCTCCCACTCACCTTCAC >32119_32119_2_GABRB3-FAF1_GABRB3_chr15_27017548_ENST00000299267_FAF1_chr1_51323670_ENST00000396153_length(amino acids)=736AA_BP=101 LAARRVGGRADPSRLGRRNSAMCSGLLELLLPIWLSWTLGTRGSEPRSVNDPGNMSFVKETVDKLLKGYDIRLRPDFGGPPVCVGMNIDI ASIDMVSEVNMACTGIENIDEAITLLEQNNWDLVAAINGVIPQENGILQSEYGGETIPGPAFNPASHPASAPTSSSSSAFRPVMPSRQIV ERQPRMLDFRVEYRDRNVDVVLEDTCTVGEIKQILENELQIPVSKMLLKGWKTGDVEDSTVLKSLHLPKNNSLYVLTPDLPPPSSSSHAG ALQESLNQNFMLIITHREVQREYNLNFSGSSTIQEVKRNVYDLTSIPVRHQLWEGWPTSATDDSMCLAESGLSYPCHRLTVGRRSSPAQT REQSEEQITDVHMVSDSDGDDFEDATEFGVDDGEVFGMASSALRKSPMMPENAENEGDALLQFTAEFSSRYGDCHPVFFIGSLEAAFQEA FYVKARDRKLLAIYLHHDESVLTNVFCSQMLCAESIVSYLSQNFITWAWDLTKDSNRARFLTMCNRHFGSVVAQTIRTQKTDQFPLFLII MGKRSSNEVLNVIQGNTTVDELMMRLMAAMEIFTAQQQEDIKDEDEREARENVKREQDEAYRLSLEADRAKREAHEREMAEQFRLEQIRK EQEEEREAIRLSLEQALPPEPKEENAEPVSKLRIRTPSGEFLERRFLASNKLQIVFDFVASKGFPWDEYKLLSTFPRRDVTQLDPNKSLL -------------------------------------------------------------- >32119_32119_3_GABRB3-FAF1_GABRB3_chr15_27017548_ENST00000311550_FAF1_chr1_51323670_ENST00000371778_length(transcript)=2663nt_BP=352nt TCCGGGCCAGCGCGGCGGCGGCGGCGGCGGCGGCAGCAGCAGGAGCAGCCCCGGCTGCGGGTCGCGACGGCGGCGGGGCGCCCCCTCCCC CGTGCCGGGGCGCGGCGGAGGGATGTGGGGCCTTGCGGGAGGAAGGCTTTTCGGCATCTTCTCGGCCCCGGTGCTGGTGGCTGTGGTGTG CTGCGCCCAGAGTGTGAACGATCCCGGGAACATGTCCTTTGTGAAGGAGACGGTGGACAAGCTGTTGAAAGGCTACGACATTCGCCTAAG ACCCGACTTCGGGGGTCCCCCGGTCTGCGTGGGGATGAACATCGACATCGCCAGCATCGACATGGTTTCCGAAGTCAACATGGCATGTAC TGGCATTGAAAACATTGACGAAGCTATTACATTGCTTGAACAAAATAATTGGGACTTAGTGGCAGCTATCAATGGTGTAATACCACAGGA AAATGGCATTCTACAAAGTGAATATGGAGGTGAGACCATACCAGGACCTGCATTTAATCCAGCAAGTCATCCAGCTTCAGCTCCTACTTC CTCTTCTTCTTCAGCGTTTCGACCTGTAATGCCATCCAGGCAGATTGTAGAAAGGCAACCTCGGATGCTGGACTTCAGGGTTGAATACAG AGACAGAAATGTTGATGTGGTACTTGAAGACACCTGTACTGTTGGAGAGATTAAACAGATTCTAGAAAATGAACTTCAGATACCTGTGTC CAAAATGCTGTTAAAAGGCTGGAAGACGGGAGATGTGGAAGACAGTACGGTCCTAAAATCTCTACACTTGCCAAAAAACAACAGTCTTTA TGTCCTTACACCAGATTTGCCACCACCTTCATCATCTAGTCATGCTGGTGCCCTGCAGGAGTCATTAAATCAAAACTTCATGCTGATCAT CACCCACCGAGAAGTCCAGCGGGAGTACAACCTGAACTTCTCAGGAAGCAGTACTATTCAAGAGGTAAAGAGAAATGTGTATGACCTTAC AAGTATCCCCGTTCGCCACCAATTATGGGAGGGCTGGCCAACTTCTGCTACAGACGACTCAATGTGTCTTGCTGAATCAGGGCTCTCTTA TCCCTGCCATCGACTTACAGTGGGAAGAAGATCTTCACCTGCACAGACCCGGGAACAGTCGGAAGAACAAATCACCGATGTTCATATGGT TAGTGATAGCGATGGAGATGACTTTGAAGATGCTACAGAATTTGGGGTGGATGATGGAGAAGTATTTGGCATGGCGTCATCTGCCTTGAG AAAATCTCCAATGATGCCAGAAAACGCAGAAAATGAAGGAGATGCCTTATTACAATTTACAGCAGAGTTTTCTTCAAGATATGGTGATTG CCATCCTGTATTTTTTATTGGCTCATTAGAAGCTGCTTTTCAAGAGGCCTTCTATGTGAAAGCCCGAGATAGAAAGCTTCTTGCTATCTA CCTCCACCATGATGAAAGTGTGTTAACCAACGTGTTCTGCTCACAAATGCTTTGTGCTGAATCCATTGTTTCTTATCTGAGTCAAAATTT TATAACCTGGGCTTGGGATCTGACAAAGGACTCCAACAGAGCAAGATTTCTCACTATGTGCAATAGACACTTTGGCAGTGTTGTGGCACA AACCATTCGGACTCAAAAAACGGATCAGTTTCCGCTTTTCCTGATTATTATGGGAAAGCGATCATCTAATGAAGTGTTGAATGTGATACA AGGGAACACAACAGTAGATGAGTTAATGATGAGACTCATGGCTGCAATGGAGATCTTCACAGCCCAACAACAGGAAGATATAAAGGACGA GGATGAACGTGAAGCCAGAGAAAATGTGAAGAGAGAGCAAGATGAGGCCTATCGCCTTTCACTTGAGGCTGACAGAGCAAAGAGGGAAGC TCACGAGAGAGAGATGGCAGAACAGTTTCGTTTGGAGCAGATTCGCAAAGAACAAGAAGAGGAACGTGAGGCCATCCGGCTGTCCTTAGA GCAAGCCCTGCCTCCTGAGCCAAAGGAAGAAAATGCTGAGCCTGTGAGCAAACTGCGGATCCGGACCCCCAGTGGCGAGTTCTTGGAGCG GCGTTTCCTGGCCAGCAACAAGCTCCAGATTGTCTTTGATTTTGTAGCTTCCAAAGGATTTCCATGGGATGAGTACAAGTTACTGAGCAC CTTTCCTAGGAGAGACGTAACTCAACTGGACCCAAATAAATCATTATTGGAGGTAAAGTTGTTCCCTCAAGAAACCCTTTTCCTTGAAGC AAAAGAGTAAACACGGCCCAGCGGTGGAACCAGCCATTCCTTGACAAGCCAGCAGCCTGCGTCAGGAGAAGGGCTCCTCGCCAACCCACC CACACGCTCGTCTCACTCAATTCAATGTCACACTTCTGCCTCTTGCAAAATTGCTGGAAAAAGTAATAATAAATATAGCTACTTAAGATT TCCCATCCATGAGTATATATTCCCAACCCTTATTACAGAGAATTACAACTCTGCCACCCTCCCCTACCCCCTGCACTTCACCCTCCTTCA ATGACGAATGCATTGTTCAAGTGTGAGTGATCACTAAATAGAATTTTTACCTCTCCAGTGCCCATCTTTTCCCCACAGTGTCTAGGACAG >32119_32119_3_GABRB3-FAF1_GABRB3_chr15_27017548_ENST00000311550_FAF1_chr1_51323670_ENST00000371778_length(amino acids)=715AA_BP=80 MWGLAGGRLFGIFSAPVLVAVVCCAQSVNDPGNMSFVKETVDKLLKGYDIRLRPDFGGPPVCVGMNIDIASIDMVSEVNMACTGIENIDE AITLLEQNNWDLVAAINGVIPQENGILQSEYGGETIPGPAFNPASHPASAPTSSSSSAFRPVMPSRQIVERQPRMLDFRVEYRDRNVDVV LEDTCTVGEIKQILENELQIPVSKMLLKGWKTGDVEDSTVLKSLHLPKNNSLYVLTPDLPPPSSSSHAGALQESLNQNFMLIITHREVQR EYNLNFSGSSTIQEVKRNVYDLTSIPVRHQLWEGWPTSATDDSMCLAESGLSYPCHRLTVGRRSSPAQTREQSEEQITDVHMVSDSDGDD FEDATEFGVDDGEVFGMASSALRKSPMMPENAENEGDALLQFTAEFSSRYGDCHPVFFIGSLEAAFQEAFYVKARDRKLLAIYLHHDESV LTNVFCSQMLCAESIVSYLSQNFITWAWDLTKDSNRARFLTMCNRHFGSVVAQTIRTQKTDQFPLFLIIMGKRSSNEVLNVIQGNTTVDE LMMRLMAAMEIFTAQQQEDIKDEDEREARENVKREQDEAYRLSLEADRAKREAHEREMAEQFRLEQIRKEQEEEREAIRLSLEQALPPEP -------------------------------------------------------------- >32119_32119_4_GABRB3-FAF1_GABRB3_chr15_27017548_ENST00000311550_FAF1_chr1_51323670_ENST00000396153_length(transcript)=4222nt_BP=352nt TCCGGGCCAGCGCGGCGGCGGCGGCGGCGGCGGCAGCAGCAGGAGCAGCCCCGGCTGCGGGTCGCGACGGCGGCGGGGCGCCCCCTCCCC CGTGCCGGGGCGCGGCGGAGGGATGTGGGGCCTTGCGGGAGGAAGGCTTTTCGGCATCTTCTCGGCCCCGGTGCTGGTGGCTGTGGTGTG CTGCGCCCAGAGTGTGAACGATCCCGGGAACATGTCCTTTGTGAAGGAGACGGTGGACAAGCTGTTGAAAGGCTACGACATTCGCCTAAG ACCCGACTTCGGGGGTCCCCCGGTCTGCGTGGGGATGAACATCGACATCGCCAGCATCGACATGGTTTCCGAAGTCAACATGGCATGTAC TGGCATTGAAAACATTGACGAAGCTATTACATTGCTTGAACAAAATAATTGGGACTTAGTGGCAGCTATCAATGGTGTAATACCACAGGA AAATGGCATTCTACAAAGTGAATATGGAGGTGAGACCATACCAGGACCTGCATTTAATCCAGCAAGTCATCCAGCTTCAGCTCCTACTTC CTCTTCTTCTTCAGCGTTTCGACCTGTAATGCCATCCAGGCAGATTGTAGAAAGGCAACCTCGGATGCTGGACTTCAGGGTTGAATACAG AGACAGAAATGTTGATGTGGTACTTGAAGACACCTGTACTGTTGGAGAGATTAAACAGATTCTAGAAAATGAACTTCAGATACCTGTGTC CAAAATGCTGTTAAAAGGCTGGAAGACGGGAGATGTGGAAGACAGTACGGTCCTAAAATCTCTACACTTGCCAAAAAACAACAGTCTTTA TGTCCTTACACCAGATTTGCCACCACCTTCATCATCTAGTCATGCTGGTGCCCTGCAGGAGTCATTAAATCAAAACTTCATGCTGATCAT CACCCACCGAGAAGTCCAGCGGGAGTACAACCTGAACTTCTCAGGAAGCAGTACTATTCAAGAGGTAAAGAGAAATGTGTATGACCTTAC AAGTATCCCCGTTCGCCACCAATTATGGGAGGGCTGGCCAACTTCTGCTACAGACGACTCAATGTGTCTTGCTGAATCAGGGCTCTCTTA TCCCTGCCATCGACTTACAGTGGGAAGAAGATCTTCACCTGCACAGACCCGGGAACAGTCGGAAGAACAAATCACCGATGTTCATATGGT TAGTGATAGCGATGGAGATGACTTTGAAGATGCTACAGAATTTGGGGTGGATGATGGAGAAGTATTTGGCATGGCGTCATCTGCCTTGAG AAAATCTCCAATGATGCCAGAAAACGCAGAAAATGAAGGAGATGCCTTATTACAATTTACAGCAGAGTTTTCTTCAAGATATGGTGATTG CCATCCTGTATTTTTTATTGGCTCATTAGAAGCTGCTTTTCAAGAGGCCTTCTATGTGAAAGCCCGAGATAGAAAGCTTCTTGCTATCTA CCTCCACCATGATGAAAGTGTGTTAACCAACGTGTTCTGCTCACAAATGCTTTGTGCTGAATCCATTGTTTCTTATCTGAGTCAAAATTT TATAACCTGGGCTTGGGATCTGACAAAGGACTCCAACAGAGCAAGATTTCTCACTATGTGCAATAGACACTTTGGCAGTGTTGTGGCACA AACCATTCGGACTCAAAAAACGGATCAGTTTCCGCTTTTCCTGATTATTATGGGAAAGCGATCATCTAATGAAGTGTTGAATGTGATACA AGGGAACACAACAGTAGATGAGTTAATGATGAGACTCATGGCTGCAATGGAGATCTTCACAGCCCAACAACAGGAAGATATAAAGGACGA GGATGAACGTGAAGCCAGAGAAAATGTGAAGAGAGAGCAAGATGAGGCCTATCGCCTTTCACTTGAGGCTGACAGAGCAAAGAGGGAAGC TCACGAGAGAGAGATGGCAGAACAGTTTCGTTTGGAGCAGATTCGCAAAGAACAAGAAGAGGAACGTGAGGCCATCCGGCTGTCCTTAGA GCAAGCCCTGCCTCCTGAGCCAAAGGAAGAAAATGCTGAGCCTGTGAGCAAACTGCGGATCCGGACCCCCAGTGGCGAGTTCTTGGAGCG GCGTTTCCTGGCCAGCAACAAGCTCCAGATTGTCTTTGATTTTGTAGCTTCCAAAGGATTTCCATGGGATGAGTACAAGTTACTGAGCAC CTTTCCTAGGAGAGACGTAACTCAACTGGACCCAAATAAATCATTATTGGAGGTAAAGTTGTTCCCTCAAGAAACCCTTTTCCTTGAAGC AAAAGAGTAAACACGGCCCAGCGGTGGAACCAGCCATTCCTTGACAAGCCAGCAGCCTGCGTCAGGAGAAGGGCTCCTCGCCAACCCACC CACACGCTCGTCTCACTCAATTCAATGTCACACTTCTGCCTCTTGCAAAATTGCTGGAAAAAGTAATAATAAATATAGCTACTTAAGATT TCCCATCCATGAGTATATATTCCCAACCCTTATTACAGAGAATTACAACTCTGCCACCCTCCCCTACCCCCTGCACTTCACCCTCCTTCA ATGACGAATGCATTGTTCAAGTGTGAGTGATCACTAAATAGAATTTTTACCTCTCCAGTGCCCATCTTTTCCCCACAGTGTCTAGGACAG TTCTGTCTGTTCTGTGACACCAGGATGCTGTATATTTGATATATGTCTTTTTATTTTCATGACTGAATTTCTACTTCATCACCTAATTTT AAGGGGCAGAGGGAAAAAAAGTCAAATGAGACATTGTCGGCATGGAGATTAAACATTGTAGGAAAAAAGTATACCATTTTTGTTAGAACT TTCTGATGGCTTTACTAAGATGTCAGGTTTTGTTTGAGGACTGAATTTGACATATATGCAAGATATTTATTTACTGCTGCTGCCTTGGGT CTCCAGGTTCTACCTAGGAGGTATTTGCTGTTCCATTGCAGCATAGGGAAACTGTTCAAGCACACAATGTGAATGTTGAGATCATGTGCA GAGAGGCCAGTACCAAAACTTCAGTATCTGGCCCAATGGCAAGAGGCTACTGTTAGGTTTGCATTTGGGCAGTTAGAACCTCACAGATAC CAGCTCCCAAGTTGCTAGTCCATCAGTGTAAACTGAACACAATTCTCTCTTGCTTTCTCTCTCTCTACTCCCTCACACATTTGGACCTTG TCACTTGGTGTTTAAGCACCTTGCCTATCAACAAAATCTGATGAGCAGCCCCATGGACTCTCCTGTAATAAGGAACTTGCTCTACTATTT TATTCTTTTAATGTTTTAGTATTTGATATTGGACTCAAATGAAAGGGATCTCATTCTGTGGCTGAAAAATCAGACTTCATATGTTGAAGA GAGCAAACTTGGGGACTCAACTCAGAAGACATGTGTTGCCTGAAACCTGCATATAATAATTTTTGATTTGATTTAGTAAGTGTGGATTTT TCTTAATCTACAGATTTGGGGTTTGGGGTTTAGATCATGAGAACACCGTTTATACCTTCACAGCCAATGATTTATTTTTAGTCTTGAAAT ATTTCTCCATATCTGTTTTTGTGTCACCTGTGGGTTTTATCCTAGGGGTTGGGATCCTGATTTTAACATTTTGTACTTGTCCAAAAAAGA GTTCAAATGCTGGGTTTGTTCCCCCAGCCTCGGCCAAGGGGTTCTCAGAAGATTCTAACCAAAGCTGGAGATAGGTCTGCTCATTTTCCT TCTGCCCAGAAGTGGATGTTGGCCAGGAAAATTACACCTTGTGTCTTCTCTGATGCTCCAACCAGGGACCTCTCCAGATTACTATCTAGC ACAGACTAGTGCTACATCTGCCTAGGTATGGGCTTTCTCTGGCAGCAGGGGTCTCTCTAGGGAGGCTGAGAGACCCATGGGTCTCCCTTC AGGGGAAGTGTTCAGGGGAGTTCAAACTGAACACTTCTCTCCAGCTCTATTCCTATCTTCCTAATCTAATGGCTCTACAAGATAGTCATT TCCAGTGCTACAGATGCACCAGGGCACCACCTCTTTTTTTTTCTAGGTAGACCTTGTTCTGTAGCTGCTGTGAAGAAGCTGCAGCCCTGA ACTCAGGTCATACTCAGGAACAGCAGCAGGGGTGTGGGTGGGGTTTGAGGGAAGGTACTCTGAATTCACCTTCATGTTTAACCTGTTCCA >32119_32119_4_GABRB3-FAF1_GABRB3_chr15_27017548_ENST00000311550_FAF1_chr1_51323670_ENST00000396153_length(amino acids)=715AA_BP=80 MWGLAGGRLFGIFSAPVLVAVVCCAQSVNDPGNMSFVKETVDKLLKGYDIRLRPDFGGPPVCVGMNIDIASIDMVSEVNMACTGIENIDE AITLLEQNNWDLVAAINGVIPQENGILQSEYGGETIPGPAFNPASHPASAPTSSSSSAFRPVMPSRQIVERQPRMLDFRVEYRDRNVDVV LEDTCTVGEIKQILENELQIPVSKMLLKGWKTGDVEDSTVLKSLHLPKNNSLYVLTPDLPPPSSSSHAGALQESLNQNFMLIITHREVQR EYNLNFSGSSTIQEVKRNVYDLTSIPVRHQLWEGWPTSATDDSMCLAESGLSYPCHRLTVGRRSSPAQTREQSEEQITDVHMVSDSDGDD FEDATEFGVDDGEVFGMASSALRKSPMMPENAENEGDALLQFTAEFSSRYGDCHPVFFIGSLEAAFQEAFYVKARDRKLLAIYLHHDESV LTNVFCSQMLCAESIVSYLSQNFITWAWDLTKDSNRARFLTMCNRHFGSVVAQTIRTQKTDQFPLFLIIMGKRSSNEVLNVIQGNTTVDE LMMRLMAAMEIFTAQQQEDIKDEDEREARENVKREQDEAYRLSLEADRAKREAHEREMAEQFRLEQIRKEQEEEREAIRLSLEQALPPEP -------------------------------------------------------------- >32119_32119_5_GABRB3-FAF1_GABRB3_chr15_27017548_ENST00000541819_FAF1_chr1_51323670_ENST00000371778_length(transcript)=2822nt_BP=511nt ACAGAGTCCTTCCTGTTTCCAGTCTAGAGGCTCCAGGGAGGTGAGACGACCACTCCCACCAGCAGCAGGCCCTGTGCTGGCTGTGTCGCA GGTGCAGAGTGAGATGCAGCAGCTCAGGAGGCTCTGGGTCCTGGCAGCTCAACCCTTCTGCCACCTACCAGAGAGGTGTCGCCTGTTCTT TGAAATCGGGGGCATTTCATTGGCGATGCCCCAGTGCCTTCTCTGGATTTGCCTGGCTGTGTGGGAGGCACGAGGAGACCTCCCATTCAT TGCTGAGAATGATGCCGTCCTCACGGTGAACTGGAACGCAGTCAAAGAACACAGAACATTTTATGCCATTTATGAAACCAGTGTGAACGA TCCCGGGAACATGTCCTTTGTGAAGGAGACGGTGGACAAGCTGTTGAAAGGCTACGACATTCGCCTAAGACCCGACTTCGGGGGTCCCCC GGTCTGCGTGGGGATGAACATCGACATCGCCAGCATCGACATGGTTTCCGAAGTCAACATGGCATGTACTGGCATTGAAAACATTGACGA AGCTATTACATTGCTTGAACAAAATAATTGGGACTTAGTGGCAGCTATCAATGGTGTAATACCACAGGAAAATGGCATTCTACAAAGTGA ATATGGAGGTGAGACCATACCAGGACCTGCATTTAATCCAGCAAGTCATCCAGCTTCAGCTCCTACTTCCTCTTCTTCTTCAGCGTTTCG ACCTGTAATGCCATCCAGGCAGATTGTAGAAAGGCAACCTCGGATGCTGGACTTCAGGGTTGAATACAGAGACAGAAATGTTGATGTGGT ACTTGAAGACACCTGTACTGTTGGAGAGATTAAACAGATTCTAGAAAATGAACTTCAGATACCTGTGTCCAAAATGCTGTTAAAAGGCTG GAAGACGGGAGATGTGGAAGACAGTACGGTCCTAAAATCTCTACACTTGCCAAAAAACAACAGTCTTTATGTCCTTACACCAGATTTGCC ACCACCTTCATCATCTAGTCATGCTGGTGCCCTGCAGGAGTCATTAAATCAAAACTTCATGCTGATCATCACCCACCGAGAAGTCCAGCG GGAGTACAACCTGAACTTCTCAGGAAGCAGTACTATTCAAGAGGTAAAGAGAAATGTGTATGACCTTACAAGTATCCCCGTTCGCCACCA ATTATGGGAGGGCTGGCCAACTTCTGCTACAGACGACTCAATGTGTCTTGCTGAATCAGGGCTCTCTTATCCCTGCCATCGACTTACAGT GGGAAGAAGATCTTCACCTGCACAGACCCGGGAACAGTCGGAAGAACAAATCACCGATGTTCATATGGTTAGTGATAGCGATGGAGATGA CTTTGAAGATGCTACAGAATTTGGGGTGGATGATGGAGAAGTATTTGGCATGGCGTCATCTGCCTTGAGAAAATCTCCAATGATGCCAGA AAACGCAGAAAATGAAGGAGATGCCTTATTACAATTTACAGCAGAGTTTTCTTCAAGATATGGTGATTGCCATCCTGTATTTTTTATTGG CTCATTAGAAGCTGCTTTTCAAGAGGCCTTCTATGTGAAAGCCCGAGATAGAAAGCTTCTTGCTATCTACCTCCACCATGATGAAAGTGT GTTAACCAACGTGTTCTGCTCACAAATGCTTTGTGCTGAATCCATTGTTTCTTATCTGAGTCAAAATTTTATAACCTGGGCTTGGGATCT GACAAAGGACTCCAACAGAGCAAGATTTCTCACTATGTGCAATAGACACTTTGGCAGTGTTGTGGCACAAACCATTCGGACTCAAAAAAC GGATCAGTTTCCGCTTTTCCTGATTATTATGGGAAAGCGATCATCTAATGAAGTGTTGAATGTGATACAAGGGAACACAACAGTAGATGA GTTAATGATGAGACTCATGGCTGCAATGGAGATCTTCACAGCCCAACAACAGGAAGATATAAAGGACGAGGATGAACGTGAAGCCAGAGA AAATGTGAAGAGAGAGCAAGATGAGGCCTATCGCCTTTCACTTGAGGCTGACAGAGCAAAGAGGGAAGCTCACGAGAGAGAGATGGCAGA ACAGTTTCGTTTGGAGCAGATTCGCAAAGAACAAGAAGAGGAACGTGAGGCCATCCGGCTGTCCTTAGAGCAAGCCCTGCCTCCTGAGCC AAAGGAAGAAAATGCTGAGCCTGTGAGCAAACTGCGGATCCGGACCCCCAGTGGCGAGTTCTTGGAGCGGCGTTTCCTGGCCAGCAACAA GCTCCAGATTGTCTTTGATTTTGTAGCTTCCAAAGGATTTCCATGGGATGAGTACAAGTTACTGAGCACCTTTCCTAGGAGAGACGTAAC TCAACTGGACCCAAATAAATCATTATTGGAGGTAAAGTTGTTCCCTCAAGAAACCCTTTTCCTTGAAGCAAAAGAGTAAACACGGCCCAG CGGTGGAACCAGCCATTCCTTGACAAGCCAGCAGCCTGCGTCAGGAGAAGGGCTCCTCGCCAACCCACCCACACGCTCGTCTCACTCAAT TCAATGTCACACTTCTGCCTCTTGCAAAATTGCTGGAAAAAGTAATAATAAATATAGCTACTTAAGATTTCCCATCCATGAGTATATATT CCCAACCCTTATTACAGAGAATTACAACTCTGCCACCCTCCCCTACCCCCTGCACTTCACCCTCCTTCAATGACGAATGCATTGTTCAAG TGTGAGTGATCACTAAATAGAATTTTTACCTCTCCAGTGCCCATCTTTTCCCCACAGTGTCTAGGACAGTTCTGTCTGTTCTGTGACACC >32119_32119_5_GABRB3-FAF1_GABRB3_chr15_27017548_ENST00000541819_FAF1_chr1_51323670_ENST00000371778_length(amino acids)=780AA_BP=145 MAVSQVQSEMQQLRRLWVLAAQPFCHLPERCRLFFEIGGISLAMPQCLLWICLAVWEARGDLPFIAENDAVLTVNWNAVKEHRTFYAIYE TSVNDPGNMSFVKETVDKLLKGYDIRLRPDFGGPPVCVGMNIDIASIDMVSEVNMACTGIENIDEAITLLEQNNWDLVAAINGVIPQENG ILQSEYGGETIPGPAFNPASHPASAPTSSSSSAFRPVMPSRQIVERQPRMLDFRVEYRDRNVDVVLEDTCTVGEIKQILENELQIPVSKM LLKGWKTGDVEDSTVLKSLHLPKNNSLYVLTPDLPPPSSSSHAGALQESLNQNFMLIITHREVQREYNLNFSGSSTIQEVKRNVYDLTSI PVRHQLWEGWPTSATDDSMCLAESGLSYPCHRLTVGRRSSPAQTREQSEEQITDVHMVSDSDGDDFEDATEFGVDDGEVFGMASSALRKS PMMPENAENEGDALLQFTAEFSSRYGDCHPVFFIGSLEAAFQEAFYVKARDRKLLAIYLHHDESVLTNVFCSQMLCAESIVSYLSQNFIT WAWDLTKDSNRARFLTMCNRHFGSVVAQTIRTQKTDQFPLFLIIMGKRSSNEVLNVIQGNTTVDELMMRLMAAMEIFTAQQQEDIKDEDE REARENVKREQDEAYRLSLEADRAKREAHEREMAEQFRLEQIRKEQEEEREAIRLSLEQALPPEPKEENAEPVSKLRIRTPSGEFLERRF -------------------------------------------------------------- >32119_32119_6_GABRB3-FAF1_GABRB3_chr15_27017548_ENST00000541819_FAF1_chr1_51323670_ENST00000396153_length(transcript)=4381nt_BP=511nt ACAGAGTCCTTCCTGTTTCCAGTCTAGAGGCTCCAGGGAGGTGAGACGACCACTCCCACCAGCAGCAGGCCCTGTGCTGGCTGTGTCGCA GGTGCAGAGTGAGATGCAGCAGCTCAGGAGGCTCTGGGTCCTGGCAGCTCAACCCTTCTGCCACCTACCAGAGAGGTGTCGCCTGTTCTT TGAAATCGGGGGCATTTCATTGGCGATGCCCCAGTGCCTTCTCTGGATTTGCCTGGCTGTGTGGGAGGCACGAGGAGACCTCCCATTCAT TGCTGAGAATGATGCCGTCCTCACGGTGAACTGGAACGCAGTCAAAGAACACAGAACATTTTATGCCATTTATGAAACCAGTGTGAACGA TCCCGGGAACATGTCCTTTGTGAAGGAGACGGTGGACAAGCTGTTGAAAGGCTACGACATTCGCCTAAGACCCGACTTCGGGGGTCCCCC GGTCTGCGTGGGGATGAACATCGACATCGCCAGCATCGACATGGTTTCCGAAGTCAACATGGCATGTACTGGCATTGAAAACATTGACGA AGCTATTACATTGCTTGAACAAAATAATTGGGACTTAGTGGCAGCTATCAATGGTGTAATACCACAGGAAAATGGCATTCTACAAAGTGA ATATGGAGGTGAGACCATACCAGGACCTGCATTTAATCCAGCAAGTCATCCAGCTTCAGCTCCTACTTCCTCTTCTTCTTCAGCGTTTCG ACCTGTAATGCCATCCAGGCAGATTGTAGAAAGGCAACCTCGGATGCTGGACTTCAGGGTTGAATACAGAGACAGAAATGTTGATGTGGT ACTTGAAGACACCTGTACTGTTGGAGAGATTAAACAGATTCTAGAAAATGAACTTCAGATACCTGTGTCCAAAATGCTGTTAAAAGGCTG GAAGACGGGAGATGTGGAAGACAGTACGGTCCTAAAATCTCTACACTTGCCAAAAAACAACAGTCTTTATGTCCTTACACCAGATTTGCC ACCACCTTCATCATCTAGTCATGCTGGTGCCCTGCAGGAGTCATTAAATCAAAACTTCATGCTGATCATCACCCACCGAGAAGTCCAGCG GGAGTACAACCTGAACTTCTCAGGAAGCAGTACTATTCAAGAGGTAAAGAGAAATGTGTATGACCTTACAAGTATCCCCGTTCGCCACCA ATTATGGGAGGGCTGGCCAACTTCTGCTACAGACGACTCAATGTGTCTTGCTGAATCAGGGCTCTCTTATCCCTGCCATCGACTTACAGT GGGAAGAAGATCTTCACCTGCACAGACCCGGGAACAGTCGGAAGAACAAATCACCGATGTTCATATGGTTAGTGATAGCGATGGAGATGA CTTTGAAGATGCTACAGAATTTGGGGTGGATGATGGAGAAGTATTTGGCATGGCGTCATCTGCCTTGAGAAAATCTCCAATGATGCCAGA AAACGCAGAAAATGAAGGAGATGCCTTATTACAATTTACAGCAGAGTTTTCTTCAAGATATGGTGATTGCCATCCTGTATTTTTTATTGG CTCATTAGAAGCTGCTTTTCAAGAGGCCTTCTATGTGAAAGCCCGAGATAGAAAGCTTCTTGCTATCTACCTCCACCATGATGAAAGTGT GTTAACCAACGTGTTCTGCTCACAAATGCTTTGTGCTGAATCCATTGTTTCTTATCTGAGTCAAAATTTTATAACCTGGGCTTGGGATCT GACAAAGGACTCCAACAGAGCAAGATTTCTCACTATGTGCAATAGACACTTTGGCAGTGTTGTGGCACAAACCATTCGGACTCAAAAAAC GGATCAGTTTCCGCTTTTCCTGATTATTATGGGAAAGCGATCATCTAATGAAGTGTTGAATGTGATACAAGGGAACACAACAGTAGATGA GTTAATGATGAGACTCATGGCTGCAATGGAGATCTTCACAGCCCAACAACAGGAAGATATAAAGGACGAGGATGAACGTGAAGCCAGAGA AAATGTGAAGAGAGAGCAAGATGAGGCCTATCGCCTTTCACTTGAGGCTGACAGAGCAAAGAGGGAAGCTCACGAGAGAGAGATGGCAGA ACAGTTTCGTTTGGAGCAGATTCGCAAAGAACAAGAAGAGGAACGTGAGGCCATCCGGCTGTCCTTAGAGCAAGCCCTGCCTCCTGAGCC AAAGGAAGAAAATGCTGAGCCTGTGAGCAAACTGCGGATCCGGACCCCCAGTGGCGAGTTCTTGGAGCGGCGTTTCCTGGCCAGCAACAA GCTCCAGATTGTCTTTGATTTTGTAGCTTCCAAAGGATTTCCATGGGATGAGTACAAGTTACTGAGCACCTTTCCTAGGAGAGACGTAAC TCAACTGGACCCAAATAAATCATTATTGGAGGTAAAGTTGTTCCCTCAAGAAACCCTTTTCCTTGAAGCAAAAGAGTAAACACGGCCCAG CGGTGGAACCAGCCATTCCTTGACAAGCCAGCAGCCTGCGTCAGGAGAAGGGCTCCTCGCCAACCCACCCACACGCTCGTCTCACTCAAT TCAATGTCACACTTCTGCCTCTTGCAAAATTGCTGGAAAAAGTAATAATAAATATAGCTACTTAAGATTTCCCATCCATGAGTATATATT CCCAACCCTTATTACAGAGAATTACAACTCTGCCACCCTCCCCTACCCCCTGCACTTCACCCTCCTTCAATGACGAATGCATTGTTCAAG TGTGAGTGATCACTAAATAGAATTTTTACCTCTCCAGTGCCCATCTTTTCCCCACAGTGTCTAGGACAGTTCTGTCTGTTCTGTGACACC AGGATGCTGTATATTTGATATATGTCTTTTTATTTTCATGACTGAATTTCTACTTCATCACCTAATTTTAAGGGGCAGAGGGAAAAAAAG TCAAATGAGACATTGTCGGCATGGAGATTAAACATTGTAGGAAAAAAGTATACCATTTTTGTTAGAACTTTCTGATGGCTTTACTAAGAT GTCAGGTTTTGTTTGAGGACTGAATTTGACATATATGCAAGATATTTATTTACTGCTGCTGCCTTGGGTCTCCAGGTTCTACCTAGGAGG TATTTGCTGTTCCATTGCAGCATAGGGAAACTGTTCAAGCACACAATGTGAATGTTGAGATCATGTGCAGAGAGGCCAGTACCAAAACTT CAGTATCTGGCCCAATGGCAAGAGGCTACTGTTAGGTTTGCATTTGGGCAGTTAGAACCTCACAGATACCAGCTCCCAAGTTGCTAGTCC ATCAGTGTAAACTGAACACAATTCTCTCTTGCTTTCTCTCTCTCTACTCCCTCACACATTTGGACCTTGTCACTTGGTGTTTAAGCACCT TGCCTATCAACAAAATCTGATGAGCAGCCCCATGGACTCTCCTGTAATAAGGAACTTGCTCTACTATTTTATTCTTTTAATGTTTTAGTA TTTGATATTGGACTCAAATGAAAGGGATCTCATTCTGTGGCTGAAAAATCAGACTTCATATGTTGAAGAGAGCAAACTTGGGGACTCAAC TCAGAAGACATGTGTTGCCTGAAACCTGCATATAATAATTTTTGATTTGATTTAGTAAGTGTGGATTTTTCTTAATCTACAGATTTGGGG TTTGGGGTTTAGATCATGAGAACACCGTTTATACCTTCACAGCCAATGATTTATTTTTAGTCTTGAAATATTTCTCCATATCTGTTTTTG TGTCACCTGTGGGTTTTATCCTAGGGGTTGGGATCCTGATTTTAACATTTTGTACTTGTCCAAAAAAGAGTTCAAATGCTGGGTTTGTTC CCCCAGCCTCGGCCAAGGGGTTCTCAGAAGATTCTAACCAAAGCTGGAGATAGGTCTGCTCATTTTCCTTCTGCCCAGAAGTGGATGTTG GCCAGGAAAATTACACCTTGTGTCTTCTCTGATGCTCCAACCAGGGACCTCTCCAGATTACTATCTAGCACAGACTAGTGCTACATCTGC CTAGGTATGGGCTTTCTCTGGCAGCAGGGGTCTCTCTAGGGAGGCTGAGAGACCCATGGGTCTCCCTTCAGGGGAAGTGTTCAGGGGAGT TCAAACTGAACACTTCTCTCCAGCTCTATTCCTATCTTCCTAATCTAATGGCTCTACAAGATAGTCATTTCCAGTGCTACAGATGCACCA GGGCACCACCTCTTTTTTTTTCTAGGTAGACCTTGTTCTGTAGCTGCTGTGAAGAAGCTGCAGCCCTGAACTCAGGTCATACTCAGGAAC AGCAGCAGGGGTGTGGGTGGGGTTTGAGGGAAGGTACTCTGAATTCACCTTCATGTTTAACCTGTTCCATCTGACTTGGGTTTCTTCATT >32119_32119_6_GABRB3-FAF1_GABRB3_chr15_27017548_ENST00000541819_FAF1_chr1_51323670_ENST00000396153_length(amino acids)=780AA_BP=145 MAVSQVQSEMQQLRRLWVLAAQPFCHLPERCRLFFEIGGISLAMPQCLLWICLAVWEARGDLPFIAENDAVLTVNWNAVKEHRTFYAIYE TSVNDPGNMSFVKETVDKLLKGYDIRLRPDFGGPPVCVGMNIDIASIDMVSEVNMACTGIENIDEAITLLEQNNWDLVAAINGVIPQENG ILQSEYGGETIPGPAFNPASHPASAPTSSSSSAFRPVMPSRQIVERQPRMLDFRVEYRDRNVDVVLEDTCTVGEIKQILENELQIPVSKM LLKGWKTGDVEDSTVLKSLHLPKNNSLYVLTPDLPPPSSSSHAGALQESLNQNFMLIITHREVQREYNLNFSGSSTIQEVKRNVYDLTSI PVRHQLWEGWPTSATDDSMCLAESGLSYPCHRLTVGRRSSPAQTREQSEEQITDVHMVSDSDGDDFEDATEFGVDDGEVFGMASSALRKS PMMPENAENEGDALLQFTAEFSSRYGDCHPVFFIGSLEAAFQEAFYVKARDRKLLAIYLHHDESVLTNVFCSQMLCAESIVSYLSQNFIT WAWDLTKDSNRARFLTMCNRHFGSVVAQTIRTQKTDQFPLFLIIMGKRSSNEVLNVIQGNTTVDELMMRLMAAMEIFTAQQQEDIKDEDE REARENVKREQDEAYRLSLEADRAKREAHEREMAEQFRLEQIRKEQEEEREAIRLSLEQALPPEPKEENAEPVSKLRIRTPSGEFLERRF -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for GABRB3-FAF1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for GABRB3-FAF1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Hgene | GABRB3 | P28472 | DB00898 | Ethanol | Small molecule | Approved | |
| Hgene | GABRB3 | P28472 | DB06716 | Fospropofol | Potentiator | Small molecule | Approved|Illicit|Investigational |
| Hgene | GABRB3 | P28472 | DB00602 | Ivermectin | Agonist | Small molecule | Approved|Investigational|Vet_approved |
| Hgene | GABRB3 | P28472 | DB00818 | Propofol | Potentiator | Small molecule | Approved|Investigational|Vet_approved |
| Hgene | GABRB3 | P28472 | DB00592 | Piperazine | Agonist | Small molecule | Approved|Vet_approved |
| Hgene | GABRB3 | P28472 | DB00431 | Lindane | Small molecule | Approved|Withdrawn |
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Related Diseases for GABRB3-FAF1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | GABRB3 | C4310712 | EPILEPTIC ENCEPHALOPATHY, EARLY INFANTILE, 43 | 6 | CTD_human;UNIPROT |
| Hgene | GABRB3 | C0011570 | Mental Depression | 5 | PSYGENET |
| Hgene | GABRB3 | C0011581 | Depressive disorder | 5 | PSYGENET |
| Hgene | GABRB3 | C0001973 | Alcoholic Intoxication, Chronic | 4 | PSYGENET |
| Hgene | GABRB3 | C2677087 | EPILEPSY, CHILDHOOD ABSENCE, SUSCEPTIBILITY TO, 5 | 3 | GENOMICS_ENGLAND;UNIPROT |
| Hgene | GABRB3 | C0004352 | Autistic Disorder | 2 | CTD_human |
| Hgene | GABRB3 | C0005586 | Bipolar Disorder | 2 | PSYGENET |
| Hgene | GABRB3 | C0014544 | Epilepsy | 2 | CTD_human |
| Hgene | GABRB3 | C0036341 | Schizophrenia | 2 | PSYGENET |
| Hgene | GABRB3 | C0086237 | Epilepsy, Cryptogenic | 2 | CTD_human |
| Hgene | GABRB3 | C0236018 | Aura | 2 | CTD_human |
| Hgene | GABRB3 | C0238111 | Lennox-Gastaut syndrome | 2 | ORPHANET |
| Hgene | GABRB3 | C0751111 | Awakening Epilepsy | 2 | CTD_human |
| Hgene | GABRB3 | C0001890 | Akinetic Petit Mal | 1 | CTD_human |
| Hgene | GABRB3 | C0014553 | Absence Epilepsy | 1 | CTD_human |
| Hgene | GABRB3 | C0021603 | Sleep Initiation and Maintenance Disorders | 1 | CTD_human |
| Hgene | GABRB3 | C0033139 | Primary Insomnia | 1 | CTD_human |
| Hgene | GABRB3 | C0162635 | Angelman Syndrome | 1 | CTD_human |
| Hgene | GABRB3 | C0270541 | Rebound Insomnia | 1 | CTD_human |
| Hgene | GABRB3 | C0349255 | Nonorganic Insomnia | 1 | CTD_human |
| Hgene | GABRB3 | C0376634 | Craniofacial Abnormalities | 1 | CTD_human |
| Hgene | GABRB3 | C0393759 | Transient Insomnia | 1 | CTD_human |
| Hgene | GABRB3 | C0541798 | Early Awakening | 1 | CTD_human |
| Hgene | GABRB3 | C0751124 | Epilepsy, Absence, Atypical | 1 | CTD_human |
| Hgene | GABRB3 | C0751249 | Chronic Insomnia | 1 | CTD_human |
| Hgene | GABRB3 | C0751250 | Psychophysiological Insomnia | 1 | CTD_human |
| Hgene | GABRB3 | C0751251 | Secondary Insomnia | 1 | CTD_human |
| Hgene | GABRB3 | C0751252 | Sleep Initiation Dysfunction | 1 | CTD_human |
| Hgene | GABRB3 | C0917801 | Sleeplessness | 1 | CTD_human |
| Hgene | GABRB3 | C1510586 | Autism Spectrum Disorders | 1 | CTD_human |
| Hgene | GABRB3 | C1535926 | Neurodevelopmental Disorders | 1 | CTD_human |
| Hgene | GABRB3 | C1838604 | EPILEPSY, CHILDHOOD ABSENCE, 1 | 1 | ORPHANET |
| Hgene | GABRB3 | C3711376 | Isodicentric Chromosome 15 Syndrome | 1 | CTD_human |
| Hgene | GABRB3 | C4281785 | Childhood Absence Epilepsy | 1 | CTD_human |
| Hgene | GABRB3 | C4317339 | Juvenile Absence Epilepsy | 1 | CTD_human |
| Hgene | GABRB3 | C4552765 | Epilepsy, Minor | 1 | CTD_human |
| Hgene | GABRB3 | C4553705 | Absence Seizure Disorder | 1 | CTD_human |
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