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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:FRMD3-BRD4 (FusionGDB2 ID:HG257019TG23476)

Fusion Gene Summary for FRMD3-BRD4

check button Fusion gene summary
Fusion gene informationFusion gene name: FRMD3-BRD4
Fusion gene ID: hg257019tg23476
HgeneTgene
Gene symbol

FRMD3

BRD4

Gene ID

257019

23476

Gene nameFERM domain containing 3bromodomain containing 4
Synonyms4.1O|EPB41L4O|EPB41LO|P410CAP|HUNK1|HUNKI|MCAP
Cytomap('FRMD3')('BRD4')

9q21.32

19p13.12

Type of geneprotein-codingprotein-coding
DescriptionFERM domain-containing protein 3band 4.1-like protein 4band 4.1-like protein 4Oovary type protein 4.1protein 4.1Obromodomain-containing protein 4chromosome-associated proteinmitotic chromosome-associated protein
Modification date2020031320200329
UniProtAcc.

O60885

Ensembl transtripts involved in fusion geneENST00000304195, ENST00000376438, 
ENST00000328788, ENST00000376434, 
ENST00000465485, 
Fusion gene scores* DoF score5 X 5 X 5=12515 X 19 X 13=3705
# samples 528
** MAII scorelog2(5/125*10)=-1.32192809488736
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(28/3705*10)=-3.72597481024823
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: FRMD3 [Title/Abstract] AND BRD4 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointFRMD3(85987828)-BRD4(15365073), # samples:2
Anticipated loss of major functional domain due to fusion event.FRMD3-BRD4 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
FRMD3-BRD4 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
FRMD3-BRD4 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
FRMD3-BRD4 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneBRD4

GO:0032968

positive regulation of transcription elongation from RNA polymerase II promoter

19103749|23086925

TgeneBRD4

GO:0043123

positive regulation of I-kappaB kinase/NF-kappaB signaling

19103749

TgeneBRD4

GO:0045944

positive regulation of transcription by RNA polymerase II

23086925|23317504|24360279

TgeneBRD4

GO:0050727

regulation of inflammatory response

19103749

TgeneBRD4

GO:1901407

regulation of phosphorylation of RNA polymerase II C-terminal domain

23086925


check buttonFusion gene breakpoints across FRMD3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across BRD4 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-E2-A14N-01AFRMD3chr9

85987828

-BRD4chr19

15365073

-


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Fusion Gene ORF analysis for FRMD3-BRD4

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000304195ENST00000602230FRMD3chr9

85987828

-BRD4chr19

15365073

-
5CDS-intronENST00000376438ENST00000602230FRMD3chr9

85987828

-BRD4chr19

15365073

-
In-frameENST00000304195ENST00000263377FRMD3chr9

85987828

-BRD4chr19

15365073

-
In-frameENST00000304195ENST00000360016FRMD3chr9

85987828

-BRD4chr19

15365073

-
In-frameENST00000304195ENST00000371835FRMD3chr9

85987828

-BRD4chr19

15365073

-
In-frameENST00000376438ENST00000263377FRMD3chr9

85987828

-BRD4chr19

15365073

-
In-frameENST00000376438ENST00000360016FRMD3chr9

85987828

-BRD4chr19

15365073

-
In-frameENST00000376438ENST00000371835FRMD3chr9

85987828

-BRD4chr19

15365073

-
intron-3CDSENST00000328788ENST00000263377FRMD3chr9

85987828

-BRD4chr19

15365073

-
intron-3CDSENST00000328788ENST00000360016FRMD3chr9

85987828

-BRD4chr19

15365073

-
intron-3CDSENST00000328788ENST00000371835FRMD3chr9

85987828

-BRD4chr19

15365073

-
intron-3CDSENST00000376434ENST00000263377FRMD3chr9

85987828

-BRD4chr19

15365073

-
intron-3CDSENST00000376434ENST00000360016FRMD3chr9

85987828

-BRD4chr19

15365073

-
intron-3CDSENST00000376434ENST00000371835FRMD3chr9

85987828

-BRD4chr19

15365073

-
intron-3CDSENST00000465485ENST00000263377FRMD3chr9

85987828

-BRD4chr19

15365073

-
intron-3CDSENST00000465485ENST00000360016FRMD3chr9

85987828

-BRD4chr19

15365073

-
intron-3CDSENST00000465485ENST00000371835FRMD3chr9

85987828

-BRD4chr19

15365073

-
intron-intronENST00000328788ENST00000602230FRMD3chr9

85987828

-BRD4chr19

15365073

-
intron-intronENST00000376434ENST00000602230FRMD3chr9

85987828

-BRD4chr19

15365073

-
intron-intronENST00000465485ENST00000602230FRMD3chr9

85987828

-BRD4chr19

15365073

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000376438FRMD3chr985987828-ENST00000263377BRD4chr1915365073-41936102072651814
ENST00000376438FRMD3chr985987828-ENST00000371835BRD4chr1915365073-29556106020201
ENST00000376438FRMD3chr985987828-ENST00000360016BRD4chr1915365073-1513610207947246
ENST00000304195FRMD3chr985987828-ENST00000263377BRD4chr1915365073-4085502992543814
ENST00000304195FRMD3chr985987828-ENST00000371835BRD4chr1915365073-284750299623174
ENST00000304195FRMD3chr985987828-ENST00000360016BRD4chr1915365073-140550299839246

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000376438ENST00000263377FRMD3chr985987828-BRD4chr1915365073-0.025797810.9742022
ENST00000376438ENST00000371835FRMD3chr985987828-BRD4chr1915365073-0.089503210.9104968
ENST00000376438ENST00000360016FRMD3chr985987828-BRD4chr1915365073-0.0624647030.9375353
ENST00000304195ENST00000263377FRMD3chr985987828-BRD4chr1915365073-0.0262924470.9737075
ENST00000304195ENST00000371835FRMD3chr985987828-BRD4chr1915365073-0.13784940.8621506
ENST00000304195ENST00000360016FRMD3chr985987828-BRD4chr1915365073-0.085097160.91490287

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Fusion Genomic Features for FRMD3-BRD4


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for FRMD3-BRD4


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr9:85987828/chr19:15365073)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.BRD4

O60885

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Chromatin reader protein that recognizes and binds acetylated histones and plays a key role in transmission of epigenetic memory across cell divisions and transcription regulation. Remains associated with acetylated chromatin throughout the entire cell cycle and provides epigenetic memory for postmitotic G1 gene transcription by preserving acetylated chromatin status and maintaining high-order chromatin structure (PubMed:23589332, PubMed:23317504, PubMed:22334664). During interphase, plays a key role in regulating the transcription of signal-inducible genes by associating with the P-TEFb complex and recruiting it to promoters. Also recruits P-TEFb complex to distal enhancers, so called anti-pause enhancers in collaboration with JMJD6. BRD4 and JMJD6 are required to form the transcriptionally active P-TEFb complex by displacing negative regulators such as HEXIM1 and 7SKsnRNA complex from P-TEFb, thereby transforming it into an active form that can then phosphorylate the C-terminal domain (CTD) of RNA polymerase II (PubMed:23589332, PubMed:19596240, PubMed:16109377, PubMed:16109376, PubMed:24360279). Promotes phosphorylation of 'Ser-2' of the C-terminal domain (CTD) of RNA polymerase II (PubMed:23086925). According to a report, directly acts as an atypical protein kinase and mediates phosphorylation of 'Ser-2' of the C-terminal domain (CTD) of RNA polymerase II; these data however need additional evidences in vivo (PubMed:22509028). In addition to acetylated histones, also recognizes and binds acetylated RELA, leading to further recruitment of the P-TEFb complex and subsequent activation of NF-kappa-B (PubMed:19103749). Also acts as a regulator of p53/TP53-mediated transcription: following phosphorylation by CK2, recruited to p53/TP53 specific target promoters (PubMed:23317504). {ECO:0000269|PubMed:16109376, ECO:0000269|PubMed:16109377, ECO:0000269|PubMed:19103749, ECO:0000269|PubMed:19596240, ECO:0000269|PubMed:22334664, ECO:0000269|PubMed:22509028, ECO:0000269|PubMed:23086925, ECO:0000269|PubMed:23317504, ECO:0000269|PubMed:23589332, ECO:0000269|PubMed:24360279}.; FUNCTION: [Isoform B]: Acts as a chromatin insulator in the DNA damage response pathway. Inhibits DNA damage response signaling by recruiting the condensin-2 complex to acetylated histones, leading to chromatin structure remodeling, insulating the region from DNA damage response by limiting spreading of histone H2AX/H2A.x phosphorylation. {ECO:0000269|PubMed:23728299}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneBRD4chr9:85987828chr19:15365073ENST000002633779201011_10146821363.0Compositional biasNote=Poly-Pro
TgeneBRD4chr9:85987828chr19:15365073ENST000002633779201028_10336821363.0Compositional biasNote=Poly-Pro
TgeneBRD4chr9:85987828chr19:15365073ENST000002633779201283_13006821363.0Compositional biasNote=Poly-Gln
TgeneBRD4chr9:85987828chr19:15365073ENST000002633779201301_13086821363.0Compositional biasNote=Poly-Ala
TgeneBRD4chr9:85987828chr19:15365073ENST000002633779201335_13386821363.0Compositional biasNote=Poly-Arg
TgeneBRD4chr9:85987828chr19:15365073ENST00000263377920692_7176821363.0Compositional biasNote=Ser-rich
TgeneBRD4chr9:85987828chr19:15365073ENST00000263377920703_7146821363.0Compositional biasNote=Poly-Ser
TgeneBRD4chr9:85987828chr19:15365073ENST00000263377920738_7436821363.0Compositional biasNote=Poly-His
TgeneBRD4chr9:85987828chr19:15365073ENST00000263377920757_7616821363.0Compositional biasNote=Poly-Pro
TgeneBRD4chr9:85987828chr19:15365073ENST00000263377920764_7706821363.0Compositional biasNote=Poly-Pro
TgeneBRD4chr9:85987828chr19:15365073ENST00000263377920771_7756821363.0Compositional biasNote=Poly-Gln
TgeneBRD4chr9:85987828chr19:15365073ENST00000263377920776_7836821363.0Compositional biasNote=Poly-Pro
TgeneBRD4chr9:85987828chr19:15365073ENST00000263377920954_9646821363.0Compositional biasNote=Poly-Pro
TgeneBRD4chr9:85987828chr19:15365073ENST00000263377920974_9866821363.0Compositional biasNote=Poly-Pro
TgeneBRD4chr9:85987828chr19:15365073ENST000003600169121011_1014682795.0Compositional biasNote=Poly-Pro
TgeneBRD4chr9:85987828chr19:15365073ENST000003600169121028_1033682795.0Compositional biasNote=Poly-Pro
TgeneBRD4chr9:85987828chr19:15365073ENST000003600169121283_1300682795.0Compositional biasNote=Poly-Gln
TgeneBRD4chr9:85987828chr19:15365073ENST000003600169121301_1308682795.0Compositional biasNote=Poly-Ala
TgeneBRD4chr9:85987828chr19:15365073ENST000003600169121335_1338682795.0Compositional biasNote=Poly-Arg
TgeneBRD4chr9:85987828chr19:15365073ENST00000360016912692_717682795.0Compositional biasNote=Ser-rich
TgeneBRD4chr9:85987828chr19:15365073ENST00000360016912703_714682795.0Compositional biasNote=Poly-Ser
TgeneBRD4chr9:85987828chr19:15365073ENST00000360016912738_743682795.0Compositional biasNote=Poly-His
TgeneBRD4chr9:85987828chr19:15365073ENST00000360016912757_761682795.0Compositional biasNote=Poly-Pro
TgeneBRD4chr9:85987828chr19:15365073ENST00000360016912764_770682795.0Compositional biasNote=Poly-Pro
TgeneBRD4chr9:85987828chr19:15365073ENST00000360016912771_775682795.0Compositional biasNote=Poly-Gln
TgeneBRD4chr9:85987828chr19:15365073ENST00000360016912776_783682795.0Compositional biasNote=Poly-Pro
TgeneBRD4chr9:85987828chr19:15365073ENST00000360016912954_964682795.0Compositional biasNote=Poly-Pro
TgeneBRD4chr9:85987828chr19:15365073ENST00000360016912974_986682795.0Compositional biasNote=Poly-Pro
TgeneBRD4chr9:85987828chr19:15365073ENST000003718359121011_1014682723.0Compositional biasNote=Poly-Pro
TgeneBRD4chr9:85987828chr19:15365073ENST000003718359121028_1033682723.0Compositional biasNote=Poly-Pro
TgeneBRD4chr9:85987828chr19:15365073ENST000003718359121283_1300682723.0Compositional biasNote=Poly-Gln
TgeneBRD4chr9:85987828chr19:15365073ENST000003718359121301_1308682723.0Compositional biasNote=Poly-Ala
TgeneBRD4chr9:85987828chr19:15365073ENST000003718359121335_1338682723.0Compositional biasNote=Poly-Arg
TgeneBRD4chr9:85987828chr19:15365073ENST00000371835912692_717682723.0Compositional biasNote=Ser-rich
TgeneBRD4chr9:85987828chr19:15365073ENST00000371835912703_714682723.0Compositional biasNote=Poly-Ser
TgeneBRD4chr9:85987828chr19:15365073ENST00000371835912738_743682723.0Compositional biasNote=Poly-His
TgeneBRD4chr9:85987828chr19:15365073ENST00000371835912757_761682723.0Compositional biasNote=Poly-Pro
TgeneBRD4chr9:85987828chr19:15365073ENST00000371835912764_770682723.0Compositional biasNote=Poly-Pro
TgeneBRD4chr9:85987828chr19:15365073ENST00000371835912771_775682723.0Compositional biasNote=Poly-Gln
TgeneBRD4chr9:85987828chr19:15365073ENST00000371835912776_783682723.0Compositional biasNote=Poly-Pro
TgeneBRD4chr9:85987828chr19:15365073ENST00000371835912954_964682723.0Compositional biasNote=Poly-Pro
TgeneBRD4chr9:85987828chr19:15365073ENST00000371835912974_986682723.0Compositional biasNote=Poly-Pro
TgeneBRD4chr9:85987828chr19:15365073ENST000002633779201047_13626821363.0RegionNote=C-terminal (CTD) region
TgeneBRD4chr9:85987828chr19:15365073ENST000003600169121047_1362682795.0RegionNote=C-terminal (CTD) region
TgeneBRD4chr9:85987828chr19:15365073ENST000003718359121047_1362682723.0RegionNote=C-terminal (CTD) region

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneFRMD3chr9:85987828chr19:15365073ENST00000304195-31432_31298598.0DomainFERM
HgeneFRMD3chr9:85987828chr19:15365073ENST00000328788-1332_3120214.0DomainFERM
HgeneFRMD3chr9:85987828chr19:15365073ENST00000376434-11032_3120363.0DomainFERM
HgeneFRMD3chr9:85987828chr19:15365073ENST00000376438-31532_31298557.0DomainFERM
HgeneFRMD3chr9:85987828chr19:15365073ENST00000304195-314531_55198598.0TransmembraneHelical
HgeneFRMD3chr9:85987828chr19:15365073ENST00000328788-13531_5510214.0TransmembraneHelical
HgeneFRMD3chr9:85987828chr19:15365073ENST00000376434-110531_5510363.0TransmembraneHelical
HgeneFRMD3chr9:85987828chr19:15365073ENST00000376438-315531_55198557.0TransmembraneHelical
TgeneBRD4chr9:85987828chr19:15365073ENST00000263377920535_5946821363.0Compositional biasNote=Lys-rich
TgeneBRD4chr9:85987828chr19:15365073ENST00000360016912535_594682795.0Compositional biasNote=Lys-rich
TgeneBRD4chr9:85987828chr19:15365073ENST00000371835912535_594682723.0Compositional biasNote=Lys-rich
TgeneBRD4chr9:85987828chr19:15365073ENST00000263377920368_4406821363.0DomainBromo 2
TgeneBRD4chr9:85987828chr19:15365073ENST00000263377920600_6826821363.0DomainNET
TgeneBRD4chr9:85987828chr19:15365073ENST0000026337792075_1476821363.0DomainBromo 1
TgeneBRD4chr9:85987828chr19:15365073ENST00000360016912368_440682795.0DomainBromo 2
TgeneBRD4chr9:85987828chr19:15365073ENST00000360016912600_682682795.0DomainNET
TgeneBRD4chr9:85987828chr19:15365073ENST0000036001691275_147682795.0DomainBromo 1
TgeneBRD4chr9:85987828chr19:15365073ENST00000371835912368_440682723.0DomainBromo 2
TgeneBRD4chr9:85987828chr19:15365073ENST00000371835912600_682682723.0DomainNET
TgeneBRD4chr9:85987828chr19:15365073ENST0000037183591275_147682723.0DomainBromo 1
TgeneBRD4chr9:85987828chr19:15365073ENST00000263377920484_5036821363.0RegionNote=NPS region
TgeneBRD4chr9:85987828chr19:15365073ENST00000263377920524_5796821363.0RegionNote=BID region
TgeneBRD4chr9:85987828chr19:15365073ENST00000360016912484_503682795.0RegionNote=NPS region
TgeneBRD4chr9:85987828chr19:15365073ENST00000360016912524_579682795.0RegionNote=BID region
TgeneBRD4chr9:85987828chr19:15365073ENST00000371835912484_503682723.0RegionNote=NPS region
TgeneBRD4chr9:85987828chr19:15365073ENST00000371835912524_579682723.0RegionNote=BID region


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Fusion Gene Sequence for FRMD3-BRD4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>31316_31316_1_FRMD3-BRD4_FRMD3_chr9_85987828_ENST00000304195_BRD4_chr19_15365073_ENST00000263377_length(transcript)=4085nt_BP=502nt
GAGGCGGAGGCGAGCGAACAGAGGGAGGGACCCGCCCGCCGCGCCCCGGCCGCTGGGCATGTGTGTCCGCAGGCGCCCGACGCTGCCGAT
GTCCCGGGGCTGAGCCGCGCCCAGGTGTCCCGGACAGTGCGTGCGAGCGTGTGTGTCCGCGCAGGCGAGCACCGCGCCGGCCCTGAGCCT
CCCGCTCGCTCCCCACGGCCGCGGTGCATGTTCGCCTCCTGCCACTGTGTGCCGAGAGGCAGGAGGACCATGAAAATGATCCACTTTCGG
AGCTCCAGCGTCAAATCGCTCAGCCAGGAGATGAGATGCACCATCCGGCTGCTGGACGACTCGGAGATCTCCTGCCACATCCAGAGGGAA
ACCAAAGGGCAGTTTCTCATTGACCACATCTGCAACTACTACAGCCTGCTGGAGAAGGACTACTTTGGCATTCGCTATGTGGACCCAGAG
AAGCAAAGGCACTGGCTTGAACCTAACAAGTCCATCTTCAAGCAAATGAAAACTGAGAAAGTTGATGTGATTGCCGGCTCCTCCAAGATG
AAGGGCTTCTCGTCCTCAGAGTCGGAGAGCTCCAGTGAGTCCAGCTCCTCTGACAGCGAAGACTCCGAAACAGAGATGGCTCCGAAGTCA
AAAAAGAAGGGGCACCCCGGGAGGGAGCAGAAGAAGCACCATCATCACCACCATCAGCAGATGCAGCAGGCCCCGGCTCCTGTGCCCCAG
CAGCCGCCCCCGCCTCCCCAGCAGCCCCCACCGCCTCCACCTCCGCAGCAGCAACAGCAGCCGCCACCCCCGCCTCCCCCACCCTCCATG
CCGCAGCAGGCAGCCCCGGCGATGAAGTCCTCGCCCCCACCCTTCATTGCCACCCAGGTGCCCGTCCTGGAGCCCCAGCTCCCAGGCAGC
GTCTTTGACCCCATCGGCCACTTCACCCAGCCCATCCTGCACCTGCCGCAGCCTGAGCTGCCCCCTCACCTGCCCCAGCCGCCTGAGCAC
AGCACTCCACCCCATCTCAACCAGCACGCAGTGGTCTCTCCTCCAGCTTTGCACAACGCACTACCCCAGCAGCCATCACGGCCCAGCAAC
CGAGCCGCTGCCCTGCCTCCCAAGCCCGCCCGGCCCCCAGCCGTGTCACCAGCCTTGACCCAAACACCCCTGCTCCCACAGCCCCCCATG
GCCCAACCCCCCCAAGTGCTGCTGGAGGATGAAGAGCCACCTGCCCCACCCCTCACCTCCATGCAGATGCAGCTGTACCTGCAGCAGCTG
CAGAAGGTGCAGCCCCCTACGCCGCTACTCCCTTCCGTGAAGGTGCAGTCCCAGCCCCCACCCCCCCTGCCGCCCCCACCCCACCCCTCT
GTGCAGCAGCAGCTGCAGCAGCAGCCGCCACCACCCCCACCACCCCAGCCCCAGCCTCCACCCCAGCAGCAGCATCAGCCCCCTCCACGG
CCCGTGCACTTGCAGCCCATGCAGTTTTCCACCCACATCCAACAGCCCCCGCCACCCCAGGGCCAGCAGCCCCCCCATCCGCCCCCAGGC
CAGCAGCCACCCCCGCCGCAGCCTGCCAAGCCTCAGCAAGTCATCCAGCACCACCATTCACCCCGGCACCACAAGTCGGACCCCTACTCA
ACCGGTCACCTCCGCGAAGCCCCCTCCCCGCTTATGATACATTCCCCCCAGATGTCACAGTTCCAGAGCCTGACCCACCAGTCTCCACCC
CAGCAAAACGTCCAGCCTAAGAAACAGGAGCTGCGTGCTGCCTCCGTGGTCCAGCCCCAGCCCCTCGTGGTGGTGAAGGAGGAGAAGATC
CACTCACCCATCATCCGCAGCGAGCCCTTCAGCCCCTCGCTGCGGCCGGAGCCCCCCAAGCACCCGGAGAGCATCAAGGCCCCCGTCCAC
CTGCCCCAGCGGCCGGAAATGAAGCCTGTGGATGTCGGGAGGCCTGTGATCCGGCCCCCAGAGCAGAACGCACCGCCACCAGGGGCCCCT
GACAAGGACAAACAGAAACAGGAGCCGAAGACTCCAGTTGCGCCCAAAAAGGACCTGAAAATCAAGAACATGGGCTCCTGGGCCAGCCTA
GTGCAGAAGCATCCGACCACCCCCTCCTCCACAGCCAAGTCATCCAGCGACAGCTTCGAGCAGTTCCGCCGCGCCGCTCGGGAGAAAGAG
GAGCGTGAGAAGGCCCTGAAGGCTCAGGCCGAGCACGCTGAGAAGGAGAAGGAGCGGCTGCGGCAGGAGCGCATGAGGAGCCGAGAGGAC
GAGGATGCGCTGGAGCAGGCCCGGCGGGCCCATGAGGAGGCACGTCGGCGCCAGGAGCAGCAGCAGCAGCAGCGCCAGGAGCAACAGCAG
CAGCAGCAACAGCAAGCAGCTGCGGTGGCTGCCGCCGCCACCCCACAGGCCCAGAGCTCCCAGCCCCAGTCCATGCTGGACCAGCAGAGG
GAGTTGGCCCGGAAGCGGGAGCAGGAGCGAAGACGCCGGGAAGCCATGGCAGCTACCATTGACATGAATTTCCAGAGTGATCTATTGTCA
ATATTTGAAGAAAATCTTTTCTGAGCGCACCTAGGTGGCTTCTGACTTTGATTTTCTGGCAAAACATTGACTTTCCATAGTGTTAGGGGC
GGTGGTGGAGGTGGGATCAGCGGCCAGGGGATGCCTCAGGGCCTGGCCCTCCTGCATGCTATGCCCGGGGCAGGCCTGACGGGCAGCTGA
GGATTGCAGAGCCTGTCTGCCTTACGGCCAGTCGGACAGACGTCCCGCCACCCACCACCCCTCACAGGACGTCCGCTCAGCACACGCCTT
GTTACGAGCAAGTGCCGGCTGGACCCAAGCCCTGCATCCCCACATGCGGGGCAGAGGCCCTTCTCTCCGCCAAATGTCTACACAGTATAC
ACAGGACATCGTTGCTGCCGCCGTGACTGGTTTTCTGTCCCCAAGAACGTGACGTTCGTGATGTCCTGCCCGCCGGGAGTCTTTCCCCAC
ACCCCAGCCATCGCCGCCCGCTCCCAGGAGGCCAGGGCAGGCCTGCGTGGGCTGGAGGCGGGCGAGGCCGGCCCACCCCCTCGCTGGCAC
TGACTTTGCCTTGAACAGACCCCCCGACCCTCCCCCACAAGCCTTTAATTGAGAGCCGCTCTCTGTAAGTGTTTGCTTGTGCAAAAGGGA
ATAGTGCCGTGGAGGTGTGTGTGTCCATGGCATCCGGAGCGAGGCGACTGTCCTGCGTGGGTAGCCCTCGGCCGGGGAGTGAGGCCACCA
ACCAAAGTCAGTTCCTTCCCACCTGTGTTTCTGTTTCGTTTTTTTTTTTCTTTTTTTTCTATATATATTTTTTGTTGAATTCTATTTTAT
TTTTAATTCTCTCTTCTCCTCCAGACACAATGGCACTGCTTATCTCCGAAATGGTGTGATCGTCTCCTCATTGAGCAGCGGCTGCCACCG
CGCTGTGGGTAGTGTGTGACCGTGGCTGTACTGTATAGTGAACATAGTTGGCATATCTTTGTTTGAAGTTTGTTGGTGACTCCACCAAAC
TGGTGTGAAAAAAGAAAAAAGCTCAAAAAAATCCACAAAAAGACAAAACACACAAAAAAAATCCTGCCTATATTTTACTCAGTTTCAAAC
TTTATTAGTCTATTTTTAATTATAAAACCAGAAAGCTACAATTTCTTTTCTTTCCCCTCCACCCCCCCCCCCCCCACCCATTTGTTGGCT
TTTTTGTTTTTTAATGTCAGATCTGTTGAGTTGGTTTTTTTGGTTTTGGTTTTTGTTTTTGTTTTTGTTTTTTACTGAGAAAGGAAGGGC
CAAGGGATGAGGTGGGAACCGGGCCCTGGGGGCGCCACAGACTAAGGCAGAGACTCCCCTACCTGGCGCCCAGCCCCAACCAGCTGGCCG
CTCCTGCCCATGCTTTTTTTTTTTTTTTTTTTTAATTTTTATAATTGGAGCCCCTGGTGAGGTTACGCGTGCCATGAGAACCCACTCTAC
ACCACGACGCTGGTGCCTCAGTGTTGGCCAAACTCTGGAGTCACTGACTGGTTTGACTTTCATACGGTGAATATGCATTTGGTCTGTACT

>31316_31316_1_FRMD3-BRD4_FRMD3_chr9_85987828_ENST00000304195_BRD4_chr19_15365073_ENST00000263377_length(amino acids)=814AA_BP=424
MSRAQVSRTVRASVCVRAGEHRAGPEPPARSPRPRCMFASCHCVPRGRRTMKMIHFRSSSVKSLSQEMRCTIRLLDDSEISCHIQRETKG
QFLIDHICNYYSLLEKDYFGIRYVDPEKQRHWLEPNKSIFKQMKTEKVDVIAGSSKMKGFSSSESESSSESSSSDSEDSETEMAPKSKKK
GHPGREQKKHHHHHHQQMQQAPAPVPQQPPPPPQQPPPPPPPQQQQQPPPPPPPPSMPQQAAPAMKSSPPPFIATQVPVLEPQLPGSVFD
PIGHFTQPILHLPQPELPPHLPQPPEHSTPPHLNQHAVVSPPALHNALPQQPSRPSNRAAALPPKPARPPAVSPALTQTPLLPQPPMAQP
PQVLLEDEEPPAPPLTSMQMQLYLQQLQKVQPPTPLLPSVKVQSQPPPPLPPPPHPSVQQQLQQQPPPPPPPQPQPPPQQQHQPPPRPVH
LQPMQFSTHIQQPPPPQGQQPPHPPPGQQPPPPQPAKPQQVIQHHHSPRHHKSDPYSTGHLREAPSPLMIHSPQMSQFQSLTHQSPPQQN
VQPKKQELRAASVVQPQPLVVVKEEKIHSPIIRSEPFSPSLRPEPPKHPESIKAPVHLPQRPEMKPVDVGRPVIRPPEQNAPPPGAPDKD
KQKQEPKTPVAPKKDLKIKNMGSWASLVQKHPTTPSSTAKSSSDSFEQFRRAAREKEEREKALKAQAEHAEKEKERLRQERMRSREDEDA
LEQARRAHEEARRRQEQQQQQRQEQQQQQQQQAAAVAAAATPQAQSSQPQSMLDQQRELARKREQERRRREAMAATIDMNFQSDLLSIFE

--------------------------------------------------------------
>31316_31316_2_FRMD3-BRD4_FRMD3_chr9_85987828_ENST00000304195_BRD4_chr19_15365073_ENST00000360016_length(transcript)=1405nt_BP=502nt
GAGGCGGAGGCGAGCGAACAGAGGGAGGGACCCGCCCGCCGCGCCCCGGCCGCTGGGCATGTGTGTCCGCAGGCGCCCGACGCTGCCGAT
GTCCCGGGGCTGAGCCGCGCCCAGGTGTCCCGGACAGTGCGTGCGAGCGTGTGTGTCCGCGCAGGCGAGCACCGCGCCGGCCCTGAGCCT
CCCGCTCGCTCCCCACGGCCGCGGTGCATGTTCGCCTCCTGCCACTGTGTGCCGAGAGGCAGGAGGACCATGAAAATGATCCACTTTCGG
AGCTCCAGCGTCAAATCGCTCAGCCAGGAGATGAGATGCACCATCCGGCTGCTGGACGACTCGGAGATCTCCTGCCACATCCAGAGGGAA
ACCAAAGGGCAGTTTCTCATTGACCACATCTGCAACTACTACAGCCTGCTGGAGAAGGACTACTTTGGCATTCGCTATGTGGACCCAGAG
AAGCAAAGGCACTGGCTTGAACCTAACAAGTCCATCTTCAAGCAAATGAAAACTGAGAAAGTTGATGTGATTGCCGGCTCCTCCAAGATG
AAGGGCTTCTCGTCCTCAGAGTCGGAGAGCTCCAGTGAGTCCAGCTCCTCTGACAGCGAAGACTCCGAAACAGCTTTCTGCACCAGTGGA
GACTTCGTGTCCCCAGGGCCTTCCCCGTATCACAGTCACGTGCAGTGCGGCCGCTTCAGGGAGATGCTTCGCTGGTTTCTGGTGGATGTG
GAGCAGACTGCAGCTGGCCAGCCGCATCGCCAGTCTGCTGCTGGCCCTGCCATCACCTGGGCCCCAGCCATTGCCTACCCCTCCCCAGAG
TGTGCTCGTTGCTGTGTTGGCTGCTCCTGAATCTGCCCTAACTCCACACGCACCTGGACTTGCGTGTCCCTCCTGCAGTTCTAACTAACA
GTCCCTTCTTTTCAAGCCCCGTGGGTCTGCACGTTGGACCCTGGGTTCCCCATTAGAGCCCACCTTCTGAGCAGCAGCCTCAGTGGGAGG
TGGAGGCAGGTAGTGATGCTGGGTGCCAGGTGGGAGTGGAGAGGGGACTGCTCTCCTCCAAGTGTGCACTTTCCTCATTATTCTCAGGGG
CGCAGATGCTCAGGCTGGCGCAGGGGAGAGGCTAGGGAGGGAGCCATGGTGCCCAGAAGGCCTGGCGACCAGCCCCTGCTGAGAGATGGA
GCTAACATCCTGTGTTTACGGCCAACGGGGTTGCCGCTAGGCTGGTGCAGCTGTCAGTGAGCTGGCGTGCTGCAGACCACCTGAGAGCTG
GCCCTAGGGTCTCAGGCAGACTGGGGAGTGGGGATCCACAGTGGGAAACCTGTGTTTTGGCAGTAGACTCCTGCATGTTCTCCCACGGGC

>31316_31316_2_FRMD3-BRD4_FRMD3_chr9_85987828_ENST00000304195_BRD4_chr19_15365073_ENST00000360016_length(amino acids)=246AA_BP=135
MSRAQVSRTVRASVCVRAGEHRAGPEPPARSPRPRCMFASCHCVPRGRRTMKMIHFRSSSVKSLSQEMRCTIRLLDDSEISCHIQRETKG
QFLIDHICNYYSLLEKDYFGIRYVDPEKQRHWLEPNKSIFKQMKTEKVDVIAGSSKMKGFSSSESESSSESSSSDSEDSETAFCTSGDFV

--------------------------------------------------------------
>31316_31316_3_FRMD3-BRD4_FRMD3_chr9_85987828_ENST00000304195_BRD4_chr19_15365073_ENST00000371835_length(transcript)=2847nt_BP=502nt
GAGGCGGAGGCGAGCGAACAGAGGGAGGGACCCGCCCGCCGCGCCCCGGCCGCTGGGCATGTGTGTCCGCAGGCGCCCGACGCTGCCGAT
GTCCCGGGGCTGAGCCGCGCCCAGGTGTCCCGGACAGTGCGTGCGAGCGTGTGTGTCCGCGCAGGCGAGCACCGCGCCGGCCCTGAGCCT
CCCGCTCGCTCCCCACGGCCGCGGTGCATGTTCGCCTCCTGCCACTGTGTGCCGAGAGGCAGGAGGACCATGAAAATGATCCACTTTCGG
AGCTCCAGCGTCAAATCGCTCAGCCAGGAGATGAGATGCACCATCCGGCTGCTGGACGACTCGGAGATCTCCTGCCACATCCAGAGGGAA
ACCAAAGGGCAGTTTCTCATTGACCACATCTGCAACTACTACAGCCTGCTGGAGAAGGACTACTTTGGCATTCGCTATGTGGACCCAGAG
AAGCAAAGGCACTGGCTTGAACCTAACAAGTCCATCTTCAAGCAAATGAAAACTGAGAAAGTTGATGTGATTGCCGGCTCCTCCAAGATG
AAGGGCTTCTCGTCCTCAGAGTCGGAGAGCTCCAGTGAGTCCAGCTCCTCTGACAGCGAAGACTCCGAAACAGGTCCTGCCTAATCATTG
GACACGGACTCTTAATAAAACGGTCTTCAGTTCCAGATTCCTTCCCAGCAAGCTATAGCTTAAGTCCATTTTCTTCCGTGAAAGGGACAG
GACTCCATCAAGTTATGGAATTCCTCAGAGCCCTGGGCCTGTCCCCCGGGGTGGATTAGTCATGTCCAGCAGCACACGCCTAGTCCCGCC
TTCGGGAAGGCTGCCTGCCTGGCCAGCCGCCCAGGCCTCTCTGTGTAAAGACTGCCTGGCTGTCCTGCCCAGCCTTCCTGGTTCTCTGGG
GTCCTCTGGGTGGGTGGCATCTCCTGGAGGGTGATGACAATCCCCAACACATGCATTCATGTGGTGCTACTCTGTGTGCAAAGCCAGACC
CCAAGTATGTTTTCTCTCTTTGTCCCATCCCTCTTTTTCTGGGACTTTGGACCCTAACTACTTCCCTCCTGAACCTTGCAGTGACATCAG
TCCAGGAGAGCTCTCGTTCAGTGTGCGGAAGAACACTCTGACCTCTAGAGCTGTCCTAGATAAGGAGTGGGAGCTTTAGAGGCAAGGCCT
CTAGACCCTGGAAGGCTCAGTGAGGCTCTTCCCACAGCATGCTTCTCACTGGTGCCCTGTAAGGCTCGAGCCACCGCTGACTCTGAGCCT
TTTGGAGTCTTTCCTCCTTCGTCTCCATTGTTCCCGTGCATTTCCAAAAGCTTAAGTTGCCTGGTGGGCATTTCCCCAGTTTCTTTGGCC
TCCGTCTTCTCAAGTCACATAGGGAAAGTACCTCCTGGAACCAGGCTGCAGTATGCAGGACCTGCCAGGCAGGCACTGGTGAAGGGCCTT
GGGCCTATCATCCCCCCAACCCCACCTCACCCCACCCGCCTCCTCTAGTGGGGTGAGTCTGGGCTGGTGGACCAGAGAGGGTGTCACAGA
CCCTCAGGGACTGCCCCATGGACACCTCTGACTGGTGTTAACAGTGTGAACATTTTCCCCGTCTTCAGTCCCTTAGAATGACGACAGCCC
CTGGGGTTGGGGCAGGCGAGTGTGGCCACATCATCCAAGCCCTCCCAGAGACACAAATAGGCTTTTTTGCTCTAAAAATAAATACCAGCC
CTTTTTTGGTCACAAATCCAGCATCTCAGCAGAAAACTGCCTGACATGAAAAGTCCCCTGAGGAACTGCATCTGCGTTTCAGGGGCTTTT
CATTTTTTCTCCTTTTTTAAAGTGTAGATTGTGGGTGCTTCCTAGAGGCCTGCCTTCTTCTGGAACTGGAAGTGGGCTATCACCATGGGC
AAGCCCTTGGGTGCAGGCTCCCCACCTGCCTGGGAACTCTGGCAGCTCTCCTCAGCTCCTTGGGCTTGAGCAGCTGCAACTGCCCCAGAT
TTGCTGTGGAAGCAGGGGCTAGCCCTGGCCTCACCAGGGCCTCCCGGGGCCCTGCATTGATGCTCAGGAGTTCCTGGGCTGCTCTTGATC
CTTTCTGGGCATCCAGCTTCCAGTTAAGCTCTGTTTGCCAAACAAACTATTCTCAGCTGCCCTTTGGCCTGCGCCTGATGTGTTCCTGTT
GCAGTCCCGCCTGCCTGAGACAGGAGCAGGCAGGAGAGCCTTCATGCCCAGATTCCCACAGGACAATTGGGGAGCTGCTGGCATTGTCTT
TCTGGGAAGATTCTGCTTTCTTGGACCAAATGGCAGCCTGATTACCAGTGTCGGGCCTGCATGCTGCCCCCGACACACGCACGCACGCGC
ACACACGTGTGCACATGGGCCATAGCCACAAGCCAGCTCTCCTCCAGGGTCCTTTCAACCTCGCTGTCCAGGGACCCTGTCCTTCTTGCC
CGTGGGGCTTCCATCTGGCAGAGAACGTTCAGGGCTTGTTGAACTTGAAAGCTCATTAGACTTAAGCTGTCACCTGTGCTTGGTGCCCCA
GGAACAGCCAGAGAGGACAGTGCCCACTCACTTCTTGTTGGCAGCCTCCTGTGCAGGAAGTGCCAGCCGGGCCTCGACGCACCAGCTGGC
TGTGGGTCCTGAGGAGGGGCGGGAGGCGGCCGCTCAGTGCAGATGGGGACTCCTCTCCTCTGCCCTGACCTTACCCTCCATTACCTCCTT
CACTGGAGTGGGGCTGGGGGGTGGGTGGAATCAGTGTTTTAATCGGATTTTTAAAAAACATTTTATTTCTTTGTACAATTACCATCCTAT

>31316_31316_3_FRMD3-BRD4_FRMD3_chr9_85987828_ENST00000304195_BRD4_chr19_15365073_ENST00000371835_length(amino acids)=174AA_BP=135
MSRAQVSRTVRASVCVRAGEHRAGPEPPARSPRPRCMFASCHCVPRGRRTMKMIHFRSSSVKSLSQEMRCTIRLLDDSEISCHIQRETKG

--------------------------------------------------------------
>31316_31316_4_FRMD3-BRD4_FRMD3_chr9_85987828_ENST00000376438_BRD4_chr19_15365073_ENST00000263377_length(transcript)=4193nt_BP=610nt
CGCGAGCCCGCCGGGGGTCTCAGGCTCTGGGCGTCCTCGGCGAGCGAGCCCGGGCAGAGGGAGGCGCACGAGCGCGCGCGACAGAAGGAG
GCGGGGAAAGGAGGGGGCGAGGCGGAGGCGAGCGAACAGAGGGAGGGACCCGCCCGCCGCGCCCCGGCCGCTGGGCATGTGTGTCCGCAG
GCGCCCGACGCTGCCGATGTCCCGGGGCTGAGCCGCGCCCAGGTGTCCCGGACAGTGCGTGCGAGCGTGTGTGTCCGCGCAGGCGAGCAC
CGCGCCGGCCCTGAGCCTCCCGCTCGCTCCCCACGGCCGCGGTGCATGTTCGCCTCCTGCCACTGTGTGCCGAGAGGCAGGAGGACCATG
AAAATGATCCACTTTCGGAGCTCCAGCGTCAAATCGCTCAGCCAGGAGATGAGATGCACCATCCGGCTGCTGGACGACTCGGAGATCTCC
TGCCACATCCAGAGGGAAACCAAAGGGCAGTTTCTCATTGACCACATCTGCAACTACTACAGCCTGCTGGAGAAGGACTACTTTGGCATT
CGCTATGTGGACCCAGAGAAGCAAAGGCACTGGCTTGAACCTAACAAGTCCATCTTCAAGCAAATGAAAACTGAGAAAGTTGATGTGATT
GCCGGCTCCTCCAAGATGAAGGGCTTCTCGTCCTCAGAGTCGGAGAGCTCCAGTGAGTCCAGCTCCTCTGACAGCGAAGACTCCGAAACA
GAGATGGCTCCGAAGTCAAAAAAGAAGGGGCACCCCGGGAGGGAGCAGAAGAAGCACCATCATCACCACCATCAGCAGATGCAGCAGGCC
CCGGCTCCTGTGCCCCAGCAGCCGCCCCCGCCTCCCCAGCAGCCCCCACCGCCTCCACCTCCGCAGCAGCAACAGCAGCCGCCACCCCCG
CCTCCCCCACCCTCCATGCCGCAGCAGGCAGCCCCGGCGATGAAGTCCTCGCCCCCACCCTTCATTGCCACCCAGGTGCCCGTCCTGGAG
CCCCAGCTCCCAGGCAGCGTCTTTGACCCCATCGGCCACTTCACCCAGCCCATCCTGCACCTGCCGCAGCCTGAGCTGCCCCCTCACCTG
CCCCAGCCGCCTGAGCACAGCACTCCACCCCATCTCAACCAGCACGCAGTGGTCTCTCCTCCAGCTTTGCACAACGCACTACCCCAGCAG
CCATCACGGCCCAGCAACCGAGCCGCTGCCCTGCCTCCCAAGCCCGCCCGGCCCCCAGCCGTGTCACCAGCCTTGACCCAAACACCCCTG
CTCCCACAGCCCCCCATGGCCCAACCCCCCCAAGTGCTGCTGGAGGATGAAGAGCCACCTGCCCCACCCCTCACCTCCATGCAGATGCAG
CTGTACCTGCAGCAGCTGCAGAAGGTGCAGCCCCCTACGCCGCTACTCCCTTCCGTGAAGGTGCAGTCCCAGCCCCCACCCCCCCTGCCG
CCCCCACCCCACCCCTCTGTGCAGCAGCAGCTGCAGCAGCAGCCGCCACCACCCCCACCACCCCAGCCCCAGCCTCCACCCCAGCAGCAG
CATCAGCCCCCTCCACGGCCCGTGCACTTGCAGCCCATGCAGTTTTCCACCCACATCCAACAGCCCCCGCCACCCCAGGGCCAGCAGCCC
CCCCATCCGCCCCCAGGCCAGCAGCCACCCCCGCCGCAGCCTGCCAAGCCTCAGCAAGTCATCCAGCACCACCATTCACCCCGGCACCAC
AAGTCGGACCCCTACTCAACCGGTCACCTCCGCGAAGCCCCCTCCCCGCTTATGATACATTCCCCCCAGATGTCACAGTTCCAGAGCCTG
ACCCACCAGTCTCCACCCCAGCAAAACGTCCAGCCTAAGAAACAGGAGCTGCGTGCTGCCTCCGTGGTCCAGCCCCAGCCCCTCGTGGTG
GTGAAGGAGGAGAAGATCCACTCACCCATCATCCGCAGCGAGCCCTTCAGCCCCTCGCTGCGGCCGGAGCCCCCCAAGCACCCGGAGAGC
ATCAAGGCCCCCGTCCACCTGCCCCAGCGGCCGGAAATGAAGCCTGTGGATGTCGGGAGGCCTGTGATCCGGCCCCCAGAGCAGAACGCA
CCGCCACCAGGGGCCCCTGACAAGGACAAACAGAAACAGGAGCCGAAGACTCCAGTTGCGCCCAAAAAGGACCTGAAAATCAAGAACATG
GGCTCCTGGGCCAGCCTAGTGCAGAAGCATCCGACCACCCCCTCCTCCACAGCCAAGTCATCCAGCGACAGCTTCGAGCAGTTCCGCCGC
GCCGCTCGGGAGAAAGAGGAGCGTGAGAAGGCCCTGAAGGCTCAGGCCGAGCACGCTGAGAAGGAGAAGGAGCGGCTGCGGCAGGAGCGC
ATGAGGAGCCGAGAGGACGAGGATGCGCTGGAGCAGGCCCGGCGGGCCCATGAGGAGGCACGTCGGCGCCAGGAGCAGCAGCAGCAGCAG
CGCCAGGAGCAACAGCAGCAGCAGCAACAGCAAGCAGCTGCGGTGGCTGCCGCCGCCACCCCACAGGCCCAGAGCTCCCAGCCCCAGTCC
ATGCTGGACCAGCAGAGGGAGTTGGCCCGGAAGCGGGAGCAGGAGCGAAGACGCCGGGAAGCCATGGCAGCTACCATTGACATGAATTTC
CAGAGTGATCTATTGTCAATATTTGAAGAAAATCTTTTCTGAGCGCACCTAGGTGGCTTCTGACTTTGATTTTCTGGCAAAACATTGACT
TTCCATAGTGTTAGGGGCGGTGGTGGAGGTGGGATCAGCGGCCAGGGGATGCCTCAGGGCCTGGCCCTCCTGCATGCTATGCCCGGGGCA
GGCCTGACGGGCAGCTGAGGATTGCAGAGCCTGTCTGCCTTACGGCCAGTCGGACAGACGTCCCGCCACCCACCACCCCTCACAGGACGT
CCGCTCAGCACACGCCTTGTTACGAGCAAGTGCCGGCTGGACCCAAGCCCTGCATCCCCACATGCGGGGCAGAGGCCCTTCTCTCCGCCA
AATGTCTACACAGTATACACAGGACATCGTTGCTGCCGCCGTGACTGGTTTTCTGTCCCCAAGAACGTGACGTTCGTGATGTCCTGCCCG
CCGGGAGTCTTTCCCCACACCCCAGCCATCGCCGCCCGCTCCCAGGAGGCCAGGGCAGGCCTGCGTGGGCTGGAGGCGGGCGAGGCCGGC
CCACCCCCTCGCTGGCACTGACTTTGCCTTGAACAGACCCCCCGACCCTCCCCCACAAGCCTTTAATTGAGAGCCGCTCTCTGTAAGTGT
TTGCTTGTGCAAAAGGGAATAGTGCCGTGGAGGTGTGTGTGTCCATGGCATCCGGAGCGAGGCGACTGTCCTGCGTGGGTAGCCCTCGGC
CGGGGAGTGAGGCCACCAACCAAAGTCAGTTCCTTCCCACCTGTGTTTCTGTTTCGTTTTTTTTTTTCTTTTTTTTCTATATATATTTTT
TGTTGAATTCTATTTTATTTTTAATTCTCTCTTCTCCTCCAGACACAATGGCACTGCTTATCTCCGAAATGGTGTGATCGTCTCCTCATT
GAGCAGCGGCTGCCACCGCGCTGTGGGTAGTGTGTGACCGTGGCTGTACTGTATAGTGAACATAGTTGGCATATCTTTGTTTGAAGTTTG
TTGGTGACTCCACCAAACTGGTGTGAAAAAAGAAAAAAGCTCAAAAAAATCCACAAAAAGACAAAACACACAAAAAAAATCCTGCCTATA
TTTTACTCAGTTTCAAACTTTATTAGTCTATTTTTAATTATAAAACCAGAAAGCTACAATTTCTTTTCTTTCCCCTCCACCCCCCCCCCC
CCCACCCATTTGTTGGCTTTTTTGTTTTTTAATGTCAGATCTGTTGAGTTGGTTTTTTTGGTTTTGGTTTTTGTTTTTGTTTTTGTTTTT
TACTGAGAAAGGAAGGGCCAAGGGATGAGGTGGGAACCGGGCCCTGGGGGCGCCACAGACTAAGGCAGAGACTCCCCTACCTGGCGCCCA
GCCCCAACCAGCTGGCCGCTCCTGCCCATGCTTTTTTTTTTTTTTTTTTTTAATTTTTATAATTGGAGCCCCTGGTGAGGTTACGCGTGC
CATGAGAACCCACTCTACACCACGACGCTGGTGCCTCAGTGTTGGCCAAACTCTGGAGTCACTGACTGGTTTGACTTTCATACGGTGAAT

>31316_31316_4_FRMD3-BRD4_FRMD3_chr9_85987828_ENST00000376438_BRD4_chr19_15365073_ENST00000263377_length(amino acids)=814AA_BP=424
MSRAQVSRTVRASVCVRAGEHRAGPEPPARSPRPRCMFASCHCVPRGRRTMKMIHFRSSSVKSLSQEMRCTIRLLDDSEISCHIQRETKG
QFLIDHICNYYSLLEKDYFGIRYVDPEKQRHWLEPNKSIFKQMKTEKVDVIAGSSKMKGFSSSESESSSESSSSDSEDSETEMAPKSKKK
GHPGREQKKHHHHHHQQMQQAPAPVPQQPPPPPQQPPPPPPPQQQQQPPPPPPPPSMPQQAAPAMKSSPPPFIATQVPVLEPQLPGSVFD
PIGHFTQPILHLPQPELPPHLPQPPEHSTPPHLNQHAVVSPPALHNALPQQPSRPSNRAAALPPKPARPPAVSPALTQTPLLPQPPMAQP
PQVLLEDEEPPAPPLTSMQMQLYLQQLQKVQPPTPLLPSVKVQSQPPPPLPPPPHPSVQQQLQQQPPPPPPPQPQPPPQQQHQPPPRPVH
LQPMQFSTHIQQPPPPQGQQPPHPPPGQQPPPPQPAKPQQVIQHHHSPRHHKSDPYSTGHLREAPSPLMIHSPQMSQFQSLTHQSPPQQN
VQPKKQELRAASVVQPQPLVVVKEEKIHSPIIRSEPFSPSLRPEPPKHPESIKAPVHLPQRPEMKPVDVGRPVIRPPEQNAPPPGAPDKD
KQKQEPKTPVAPKKDLKIKNMGSWASLVQKHPTTPSSTAKSSSDSFEQFRRAAREKEEREKALKAQAEHAEKEKERLRQERMRSREDEDA
LEQARRAHEEARRRQEQQQQQRQEQQQQQQQQAAAVAAAATPQAQSSQPQSMLDQQRELARKREQERRRREAMAATIDMNFQSDLLSIFE

--------------------------------------------------------------
>31316_31316_5_FRMD3-BRD4_FRMD3_chr9_85987828_ENST00000376438_BRD4_chr19_15365073_ENST00000360016_length(transcript)=1513nt_BP=610nt
CGCGAGCCCGCCGGGGGTCTCAGGCTCTGGGCGTCCTCGGCGAGCGAGCCCGGGCAGAGGGAGGCGCACGAGCGCGCGCGACAGAAGGAG
GCGGGGAAAGGAGGGGGCGAGGCGGAGGCGAGCGAACAGAGGGAGGGACCCGCCCGCCGCGCCCCGGCCGCTGGGCATGTGTGTCCGCAG
GCGCCCGACGCTGCCGATGTCCCGGGGCTGAGCCGCGCCCAGGTGTCCCGGACAGTGCGTGCGAGCGTGTGTGTCCGCGCAGGCGAGCAC
CGCGCCGGCCCTGAGCCTCCCGCTCGCTCCCCACGGCCGCGGTGCATGTTCGCCTCCTGCCACTGTGTGCCGAGAGGCAGGAGGACCATG
AAAATGATCCACTTTCGGAGCTCCAGCGTCAAATCGCTCAGCCAGGAGATGAGATGCACCATCCGGCTGCTGGACGACTCGGAGATCTCC
TGCCACATCCAGAGGGAAACCAAAGGGCAGTTTCTCATTGACCACATCTGCAACTACTACAGCCTGCTGGAGAAGGACTACTTTGGCATT
CGCTATGTGGACCCAGAGAAGCAAAGGCACTGGCTTGAACCTAACAAGTCCATCTTCAAGCAAATGAAAACTGAGAAAGTTGATGTGATT
GCCGGCTCCTCCAAGATGAAGGGCTTCTCGTCCTCAGAGTCGGAGAGCTCCAGTGAGTCCAGCTCCTCTGACAGCGAAGACTCCGAAACA
GCTTTCTGCACCAGTGGAGACTTCGTGTCCCCAGGGCCTTCCCCGTATCACAGTCACGTGCAGTGCGGCCGCTTCAGGGAGATGCTTCGC
TGGTTTCTGGTGGATGTGGAGCAGACTGCAGCTGGCCAGCCGCATCGCCAGTCTGCTGCTGGCCCTGCCATCACCTGGGCCCCAGCCATT
GCCTACCCCTCCCCAGAGTGTGCTCGTTGCTGTGTTGGCTGCTCCTGAATCTGCCCTAACTCCACACGCACCTGGACTTGCGTGTCCCTC
CTGCAGTTCTAACTAACAGTCCCTTCTTTTCAAGCCCCGTGGGTCTGCACGTTGGACCCTGGGTTCCCCATTAGAGCCCACCTTCTGAGC
AGCAGCCTCAGTGGGAGGTGGAGGCAGGTAGTGATGCTGGGTGCCAGGTGGGAGTGGAGAGGGGACTGCTCTCCTCCAAGTGTGCACTTT
CCTCATTATTCTCAGGGGCGCAGATGCTCAGGCTGGCGCAGGGGAGAGGCTAGGGAGGGAGCCATGGTGCCCAGAAGGCCTGGCGACCAG
CCCCTGCTGAGAGATGGAGCTAACATCCTGTGTTTACGGCCAACGGGGTTGCCGCTAGGCTGGTGCAGCTGTCAGTGAGCTGGCGTGCTG
CAGACCACCTGAGAGCTGGCCCTAGGGTCTCAGGCAGACTGGGGAGTGGGGATCCACAGTGGGAAACCTGTGTTTTGGCAGTAGACTCCT

>31316_31316_5_FRMD3-BRD4_FRMD3_chr9_85987828_ENST00000376438_BRD4_chr19_15365073_ENST00000360016_length(amino acids)=246AA_BP=135
MSRAQVSRTVRASVCVRAGEHRAGPEPPARSPRPRCMFASCHCVPRGRRTMKMIHFRSSSVKSLSQEMRCTIRLLDDSEISCHIQRETKG
QFLIDHICNYYSLLEKDYFGIRYVDPEKQRHWLEPNKSIFKQMKTEKVDVIAGSSKMKGFSSSESESSSESSSSDSEDSETAFCTSGDFV

--------------------------------------------------------------
>31316_31316_6_FRMD3-BRD4_FRMD3_chr9_85987828_ENST00000376438_BRD4_chr19_15365073_ENST00000371835_length(transcript)=2955nt_BP=610nt
CGCGAGCCCGCCGGGGGTCTCAGGCTCTGGGCGTCCTCGGCGAGCGAGCCCGGGCAGAGGGAGGCGCACGAGCGCGCGCGACAGAAGGAG
GCGGGGAAAGGAGGGGGCGAGGCGGAGGCGAGCGAACAGAGGGAGGGACCCGCCCGCCGCGCCCCGGCCGCTGGGCATGTGTGTCCGCAG
GCGCCCGACGCTGCCGATGTCCCGGGGCTGAGCCGCGCCCAGGTGTCCCGGACAGTGCGTGCGAGCGTGTGTGTCCGCGCAGGCGAGCAC
CGCGCCGGCCCTGAGCCTCCCGCTCGCTCCCCACGGCCGCGGTGCATGTTCGCCTCCTGCCACTGTGTGCCGAGAGGCAGGAGGACCATG
AAAATGATCCACTTTCGGAGCTCCAGCGTCAAATCGCTCAGCCAGGAGATGAGATGCACCATCCGGCTGCTGGACGACTCGGAGATCTCC
TGCCACATCCAGAGGGAAACCAAAGGGCAGTTTCTCATTGACCACATCTGCAACTACTACAGCCTGCTGGAGAAGGACTACTTTGGCATT
CGCTATGTGGACCCAGAGAAGCAAAGGCACTGGCTTGAACCTAACAAGTCCATCTTCAAGCAAATGAAAACTGAGAAAGTTGATGTGATT
GCCGGCTCCTCCAAGATGAAGGGCTTCTCGTCCTCAGAGTCGGAGAGCTCCAGTGAGTCCAGCTCCTCTGACAGCGAAGACTCCGAAACA
GGTCCTGCCTAATCATTGGACACGGACTCTTAATAAAACGGTCTTCAGTTCCAGATTCCTTCCCAGCAAGCTATAGCTTAAGTCCATTTT
CTTCCGTGAAAGGGACAGGACTCCATCAAGTTATGGAATTCCTCAGAGCCCTGGGCCTGTCCCCCGGGGTGGATTAGTCATGTCCAGCAG
CACACGCCTAGTCCCGCCTTCGGGAAGGCTGCCTGCCTGGCCAGCCGCCCAGGCCTCTCTGTGTAAAGACTGCCTGGCTGTCCTGCCCAG
CCTTCCTGGTTCTCTGGGGTCCTCTGGGTGGGTGGCATCTCCTGGAGGGTGATGACAATCCCCAACACATGCATTCATGTGGTGCTACTC
TGTGTGCAAAGCCAGACCCCAAGTATGTTTTCTCTCTTTGTCCCATCCCTCTTTTTCTGGGACTTTGGACCCTAACTACTTCCCTCCTGA
ACCTTGCAGTGACATCAGTCCAGGAGAGCTCTCGTTCAGTGTGCGGAAGAACACTCTGACCTCTAGAGCTGTCCTAGATAAGGAGTGGGA
GCTTTAGAGGCAAGGCCTCTAGACCCTGGAAGGCTCAGTGAGGCTCTTCCCACAGCATGCTTCTCACTGGTGCCCTGTAAGGCTCGAGCC
ACCGCTGACTCTGAGCCTTTTGGAGTCTTTCCTCCTTCGTCTCCATTGTTCCCGTGCATTTCCAAAAGCTTAAGTTGCCTGGTGGGCATT
TCCCCAGTTTCTTTGGCCTCCGTCTTCTCAAGTCACATAGGGAAAGTACCTCCTGGAACCAGGCTGCAGTATGCAGGACCTGCCAGGCAG
GCACTGGTGAAGGGCCTTGGGCCTATCATCCCCCCAACCCCACCTCACCCCACCCGCCTCCTCTAGTGGGGTGAGTCTGGGCTGGTGGAC
CAGAGAGGGTGTCACAGACCCTCAGGGACTGCCCCATGGACACCTCTGACTGGTGTTAACAGTGTGAACATTTTCCCCGTCTTCAGTCCC
TTAGAATGACGACAGCCCCTGGGGTTGGGGCAGGCGAGTGTGGCCACATCATCCAAGCCCTCCCAGAGACACAAATAGGCTTTTTTGCTC
TAAAAATAAATACCAGCCCTTTTTTGGTCACAAATCCAGCATCTCAGCAGAAAACTGCCTGACATGAAAAGTCCCCTGAGGAACTGCATC
TGCGTTTCAGGGGCTTTTCATTTTTTCTCCTTTTTTAAAGTGTAGATTGTGGGTGCTTCCTAGAGGCCTGCCTTCTTCTGGAACTGGAAG
TGGGCTATCACCATGGGCAAGCCCTTGGGTGCAGGCTCCCCACCTGCCTGGGAACTCTGGCAGCTCTCCTCAGCTCCTTGGGCTTGAGCA
GCTGCAACTGCCCCAGATTTGCTGTGGAAGCAGGGGCTAGCCCTGGCCTCACCAGGGCCTCCCGGGGCCCTGCATTGATGCTCAGGAGTT
CCTGGGCTGCTCTTGATCCTTTCTGGGCATCCAGCTTCCAGTTAAGCTCTGTTTGCCAAACAAACTATTCTCAGCTGCCCTTTGGCCTGC
GCCTGATGTGTTCCTGTTGCAGTCCCGCCTGCCTGAGACAGGAGCAGGCAGGAGAGCCTTCATGCCCAGATTCCCACAGGACAATTGGGG
AGCTGCTGGCATTGTCTTTCTGGGAAGATTCTGCTTTCTTGGACCAAATGGCAGCCTGATTACCAGTGTCGGGCCTGCATGCTGCCCCCG
ACACACGCACGCACGCGCACACACGTGTGCACATGGGCCATAGCCACAAGCCAGCTCTCCTCCAGGGTCCTTTCAACCTCGCTGTCCAGG
GACCCTGTCCTTCTTGCCCGTGGGGCTTCCATCTGGCAGAGAACGTTCAGGGCTTGTTGAACTTGAAAGCTCATTAGACTTAAGCTGTCA
CCTGTGCTTGGTGCCCCAGGAACAGCCAGAGAGGACAGTGCCCACTCACTTCTTGTTGGCAGCCTCCTGTGCAGGAAGTGCCAGCCGGGC
CTCGACGCACCAGCTGGCTGTGGGTCCTGAGGAGGGGCGGGAGGCGGCCGCTCAGTGCAGATGGGGACTCCTCTCCTCTGCCCTGACCTT
ACCCTCCATTACCTCCTTCACTGGAGTGGGGCTGGGGGGTGGGTGGAATCAGTGTTTTAATCGGATTTTTAAAAAACATTTTATTTCTTT

>31316_31316_6_FRMD3-BRD4_FRMD3_chr9_85987828_ENST00000376438_BRD4_chr19_15365073_ENST00000371835_length(amino acids)=201AA_BP=
MLEDGLVRFKPVPLLLWVHIANAKVVLLQQAVVVADVVNEKLPFGFPLDVAGDLRVVQQPDGASHLLAERFDAGAPKVDHFHGPPASRHT
VAGGEHAPRPWGASGRLRAGAVLACADTHARTHCPGHLGAAQPRDIGSVGRLRTHMPSGRGAAGGSLPLFARLRLAPSFPRLLLSRALVR

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Fusion Gene PPI Analysis for FRMD3-BRD4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for FRMD3-BRD4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for FRMD3-BRD4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneFRMD3C0263454Chloracne1CTD_human
TgeneC0017636Glioblastoma2CTD_human
TgeneC0334588Giant Cell Glioblastoma2CTD_human
TgeneC1621958Glioblastoma Multiforme2CTD_human
TgeneC0002170Alopecia1CTD_human
TgeneC0007102Malignant tumor of colon1CTD_human
TgeneC0009375Colonic Neoplasms1CTD_human
TgeneC0018798Congenital Heart Defects1GENOMICS_ENGLAND
TgeneC0019193Hepatitis, Toxic1CTD_human
TgeneC0020507Hyperplasia1CTD_human
TgeneC0020542Pulmonary Hypertension1CTD_human
TgeneC0025149Medulloblastoma1CTD_human
TgeneC0025958Microcephaly1GENOMICS_ENGLAND
TgeneC0029463Osteosarcoma1CTD_human
TgeneC0033578Prostatic Neoplasms1CTD_human
TgeneC0040136Thyroid Neoplasm1CTD_human
TgeneC0085413Polycystic Kidney, Autosomal Dominant1CTD_human
TgeneC0086873Pseudopelade1CTD_human
TgeneC0151468Thyroid Gland Follicular Adenoma1CTD_human
TgeneC0162311Androgenetic Alopecia1CTD_human
TgeneC0205833Medullomyoblastoma1CTD_human
TgeneC0263477Female pattern alopecia (disorder)1CTD_human
TgeneC0270972Cornelia De Lange Syndrome1CTD_human
TgeneC0278510Childhood Medulloblastoma1CTD_human
TgeneC0278876Adult Medulloblastoma1CTD_human
TgeneC0376358Malignant neoplasm of prostate1CTD_human
TgeneC0549473Thyroid carcinoma1CTD_human
TgeneC0751291Desmoplastic Medulloblastoma1CTD_human
TgeneC0860207Drug-Induced Liver Disease1CTD_human
TgeneC0887850Polycystic Kidney, Type 1 Autosomal Dominant Disease1CTD_human
TgeneC1262760Hepatitis, Drug-Induced1CTD_human
TgeneC1275668Melanotic medulloblastoma1CTD_human
TgeneC1707291NUT midline carcinoma1ORPHANET
TgeneC1802395Congenital muscular hypertrophy-cerebral syndrome1CTD_human
TgeneC1853099Cornelia de Lange Syndrome 31CTD_human
TgeneC2751306Polycystic kidney disease, type 21CTD_human
TgeneC3658290Drug-Induced Acute Liver Injury1CTD_human
TgeneC3714756Intellectual Disability1GENOMICS_ENGLAND
TgeneC4025871Abnormality of the face1GENOMICS_ENGLAND
TgeneC4083212Alopecia, Male Pattern1CTD_human
TgeneC4277682Chemical and Drug Induced Liver Injury1CTD_human
TgeneC4279912Chemically-Induced Liver Toxicity1CTD_human
TgeneC4551851Cornelia de Lange Syndrome 11CTD_human