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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ABTB2-NDUFB1 (FusionGDB2 ID:HG25841TG4707)

Fusion Gene Summary for ABTB2-NDUFB1

check button Fusion gene summary
Fusion gene informationFusion gene name: ABTB2-NDUFB1
Fusion gene ID: hg25841tg4707
HgeneTgene
Gene symbol

ABTB2

NDUFB1

Gene ID

25841

4707

Gene nameankyrin repeat and BTB domain containing 2NADH:ubiquinone oxidoreductase subunit B1
SynonymsABTB2A|BTBD22CI-MNLL|CI-SGDH|MNLL
Cytomap('ABTB2')('NDUFB1')

11p13

14q32.12

Type of geneprotein-codingprotein-coding
Descriptionankyrin repeat and BTB/POZ domain-containing protein 2ankyrin repeat and BTB (POZ) domain containing 2NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 1, 7kDaNADH-ubiquinone oxidoreductase MNLL subunitcomplex I MNLL subunitcomplex I-MNLL
Modification date2020031320200313
UniProtAcc

Q8N961

O75438

Ensembl transtripts involved in fusion geneENST00000298992, ENST00000435224, 
ENST00000530814, 
Fusion gene scores* DoF score13 X 10 X 3=3906 X 5 X 4=120
# samples 166
** MAII scorelog2(16/390*10)=-1.28540221886225
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(6/120*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ABTB2 [Title/Abstract] AND NDUFB1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointABTB2(34378248)-NDUFB1(92582573), # samples:1
ABTB2(34378248)-NDUFB1(92583986), # samples:1
Anticipated loss of major functional domain due to fusion event.ABTB2-NDUFB1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ABTB2-NDUFB1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ABTB2-NDUFB1 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across ABTB2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across NDUFB1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-AN-A0XU-01AABTB2chr11

34378248

-NDUFB1chr14

92582573

-
ChimerDB4BRCATCGA-AN-A0XU-01AABTB2chr11

34378248

-NDUFB1chr14

92583986

-


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Fusion Gene ORF analysis for ABTB2-NDUFB1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000298992ENST00000329559ABTB2chr11

34378248

-NDUFB1chr14

92583986

-
5CDS-5UTRENST00000298992ENST00000553514ABTB2chr11

34378248

-NDUFB1chr14

92583986

-
5CDS-5UTRENST00000298992ENST00000555441ABTB2chr11

34378248

-NDUFB1chr14

92583986

-
5CDS-5UTRENST00000298992ENST00000605997ABTB2chr11

34378248

-NDUFB1chr14

92583986

-
5CDS-5UTRENST00000435224ENST00000329559ABTB2chr11

34378248

-NDUFB1chr14

92583986

-
5CDS-5UTRENST00000435224ENST00000553514ABTB2chr11

34378248

-NDUFB1chr14

92583986

-
5CDS-5UTRENST00000435224ENST00000555441ABTB2chr11

34378248

-NDUFB1chr14

92583986

-
5CDS-5UTRENST00000435224ENST00000605997ABTB2chr11

34378248

-NDUFB1chr14

92583986

-
5CDS-intronENST00000298992ENST00000556555ABTB2chr11

34378248

-NDUFB1chr14

92582573

-
5CDS-intronENST00000298992ENST00000556555ABTB2chr11

34378248

-NDUFB1chr14

92583986

-
5CDS-intronENST00000435224ENST00000556555ABTB2chr11

34378248

-NDUFB1chr14

92582573

-
5CDS-intronENST00000435224ENST00000556555ABTB2chr11

34378248

-NDUFB1chr14

92583986

-
Frame-shiftENST00000298992ENST00000329559ABTB2chr11

34378248

-NDUFB1chr14

92582573

-
Frame-shiftENST00000298992ENST00000555441ABTB2chr11

34378248

-NDUFB1chr14

92582573

-
Frame-shiftENST00000435224ENST00000329559ABTB2chr11

34378248

-NDUFB1chr14

92582573

-
Frame-shiftENST00000435224ENST00000555441ABTB2chr11

34378248

-NDUFB1chr14

92582573

-
In-frameENST00000298992ENST00000553514ABTB2chr11

34378248

-NDUFB1chr14

92582573

-
In-frameENST00000298992ENST00000605997ABTB2chr11

34378248

-NDUFB1chr14

92582573

-
In-frameENST00000435224ENST00000553514ABTB2chr11

34378248

-NDUFB1chr14

92582573

-
In-frameENST00000435224ENST00000605997ABTB2chr11

34378248

-NDUFB1chr14

92582573

-
intron-3CDSENST00000530814ENST00000329559ABTB2chr11

34378248

-NDUFB1chr14

92582573

-
intron-3CDSENST00000530814ENST00000553514ABTB2chr11

34378248

-NDUFB1chr14

92582573

-
intron-3CDSENST00000530814ENST00000555441ABTB2chr11

34378248

-NDUFB1chr14

92582573

-
intron-3CDSENST00000530814ENST00000605997ABTB2chr11

34378248

-NDUFB1chr14

92582573

-
intron-5UTRENST00000530814ENST00000329559ABTB2chr11

34378248

-NDUFB1chr14

92583986

-
intron-5UTRENST00000530814ENST00000553514ABTB2chr11

34378248

-NDUFB1chr14

92583986

-
intron-5UTRENST00000530814ENST00000555441ABTB2chr11

34378248

-NDUFB1chr14

92583986

-
intron-5UTRENST00000530814ENST00000605997ABTB2chr11

34378248

-NDUFB1chr14

92583986

-
intron-intronENST00000530814ENST00000556555ABTB2chr11

34378248

-NDUFB1chr14

92582573

-
intron-intronENST00000530814ENST00000556555ABTB2chr11

34378248

-NDUFB1chr14

92583986

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000298992ABTB2chr1134378248-ENST00000553514NDUFB1chr1492582573-66355520625201
ENST00000298992ABTB2chr1134378248-ENST00000605997NDUFB1chr1492582573-66055520625201
ENST00000435224ABTB2chr1134378248-ENST00000553514NDUFB1chr1492582573-14161308591378439
ENST00000435224ABTB2chr1134378248-ENST00000605997NDUFB1chr1492582573-14131308591378439

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000298992ENST00000553514ABTB2chr1134378248-NDUFB1chr1492582573-0.0249414030.9750587
ENST00000298992ENST00000605997ABTB2chr1134378248-NDUFB1chr1492582573-0.0243736950.97562635
ENST00000435224ENST00000553514ABTB2chr1134378248-NDUFB1chr1492582573-0.075183360.9248166
ENST00000435224ENST00000605997ABTB2chr1134378248-NDUFB1chr1492582573-0.073985160.92601484

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Fusion Genomic Features for ABTB2-NDUFB1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for ABTB2-NDUFB1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr11:34378248/chr14:92582573)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ABTB2

Q8N961

NDUFB1

O75438

FUNCTION: May be involved in the initiation of hepatocyte growth. {ECO:0000250}.FUNCTION: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. {ECO:0000269|PubMed:27626371}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneABTB2chr11:34378248chr14:92582573ENST00000298992-117845_914108840.0DomainBTB
HgeneABTB2chr11:34378248chr14:92582573ENST00000435224-117845_9142941026.0DomainBTB
HgeneABTB2chr11:34378248chr14:92582573ENST00000298992-117521_550108840.0RepeatNote=ANK 1
HgeneABTB2chr11:34378248chr14:92582573ENST00000298992-117567_596108840.0RepeatNote=ANK 2
HgeneABTB2chr11:34378248chr14:92582573ENST00000298992-117606_635108840.0RepeatNote=ANK 3
HgeneABTB2chr11:34378248chr14:92582573ENST00000298992-117649_678108840.0RepeatNote=ANK 4
HgeneABTB2chr11:34378248chr14:92582573ENST00000435224-117521_5502941026.0RepeatNote=ANK 1
HgeneABTB2chr11:34378248chr14:92582573ENST00000435224-117567_5962941026.0RepeatNote=ANK 2
HgeneABTB2chr11:34378248chr14:92582573ENST00000435224-117606_6352941026.0RepeatNote=ANK 3
HgeneABTB2chr11:34378248chr14:92582573ENST00000435224-117649_6782941026.0RepeatNote=ANK 4
TgeneNDUFB1chr11:34378248chr14:92582573ENST000003295591311_2793106.0TransmembraneHelical
TgeneNDUFB1chr11:34378248chr14:92582573ENST000005535142411_274659.0TransmembraneHelical
TgeneNDUFB1chr11:34378248chr14:92582573ENST000005554411311_274659.0TransmembraneHelical
TgeneNDUFB1chr11:34378248chr14:92582573ENST000006059971311_274659.0TransmembraneHelical


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Fusion Gene Sequence for ABTB2-NDUFB1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>579_579_1_ABTB2-NDUFB1_ABTB2_chr11_34378248_ENST00000298992_NDUFB1_chr14_92582573_ENST00000553514_length(transcript)=663nt_BP=555nt
AAGGCGCTGGCGGCCGGCGGCTGCCCCAGTTCTCCGCCGAGGCGGTGAGGCGCCTGGCCGGGCTGCTCCGCAGGGCACTGATCCGCGTGG
CCCGCGAGGCGCAGCGCCTGAGCGTGCTGCACGCCAAGTGCACCCGCTTTGAGGTGCAGAGCGCCGTGCGCCTGGTGCACAGCTGGGCGC
TGGCCGAGAGCTGCGCGCTGGCAGCCGTCAAGGCGCTGTCCCTGTACAGCATGAGCGCCGGCGACGGGCTGCGCCGGGGCAAGTCCGCGC
GCTGCGGCCTCACCTTCTCAGTGGGTCGCTTTTTCCGCTGGATGGTGGACACCCGAATCTCCGTGCGCATCCACGAGTACGCAGCCATCT
CCCTCACCGCCTGCATGGAGAACCTGGTGGAGGAGATCCGGGCCAGGGTGATGGCCAGCCACAGCCCTGATGGCGGAGGGGCCGGAGGCG
GGGAGGTGTCTGCTGAGGCCCTGGAGATGGTCATCAACAACGACGCCGAGCTCTGGGGCGTCTTGCAGCCCTATGAGCATCTCATCTGCG
GCAAGAACGCCAATGGGAATTGCAACCCAGTGAAGAAGTTACCTGGAAGTAAAGACTGGCTAGATTATCGAATGTTCACATTTTAAAGTT

>579_579_1_ABTB2-NDUFB1_ABTB2_chr11_34378248_ENST00000298992_NDUFB1_chr14_92582573_ENST00000553514_length(amino acids)=201AA_BP=178
MPQFSAEAVRRLAGLLRRALIRVAREAQRLSVLHAKCTRFEVQSAVRLVHSWALAESCALAAVKALSLYSMSAGDGLRRGKSARCGLTFS
VGRFFRWMVDTRISVRIHEYAAISLTACMENLVEEIRARVMASHSPDGGGAGGGEVSAEALEMVINNDAELWGVLQPYEHLICGKNANGN

--------------------------------------------------------------
>579_579_2_ABTB2-NDUFB1_ABTB2_chr11_34378248_ENST00000298992_NDUFB1_chr14_92582573_ENST00000605997_length(transcript)=660nt_BP=555nt
AAGGCGCTGGCGGCCGGCGGCTGCCCCAGTTCTCCGCCGAGGCGGTGAGGCGCCTGGCCGGGCTGCTCCGCAGGGCACTGATCCGCGTGG
CCCGCGAGGCGCAGCGCCTGAGCGTGCTGCACGCCAAGTGCACCCGCTTTGAGGTGCAGAGCGCCGTGCGCCTGGTGCACAGCTGGGCGC
TGGCCGAGAGCTGCGCGCTGGCAGCCGTCAAGGCGCTGTCCCTGTACAGCATGAGCGCCGGCGACGGGCTGCGCCGGGGCAAGTCCGCGC
GCTGCGGCCTCACCTTCTCAGTGGGTCGCTTTTTCCGCTGGATGGTGGACACCCGAATCTCCGTGCGCATCCACGAGTACGCAGCCATCT
CCCTCACCGCCTGCATGGAGAACCTGGTGGAGGAGATCCGGGCCAGGGTGATGGCCAGCCACAGCCCTGATGGCGGAGGGGCCGGAGGCG
GGGAGGTGTCTGCTGAGGCCCTGGAGATGGTCATCAACAACGACGCCGAGCTCTGGGGCGTCTTGCAGCCCTATGAGCATCTCATCTGCG
GCAAGAACGCCAATGGGAATTGCAACCCAGTGAAGAAGTTACCTGGAAGTAAAGACTGGCTAGATTATCGAATGTTCACATTTTAAAGTT

>579_579_2_ABTB2-NDUFB1_ABTB2_chr11_34378248_ENST00000298992_NDUFB1_chr14_92582573_ENST00000605997_length(amino acids)=201AA_BP=178
MPQFSAEAVRRLAGLLRRALIRVAREAQRLSVLHAKCTRFEVQSAVRLVHSWALAESCALAAVKALSLYSMSAGDGLRRGKSARCGLTFS
VGRFFRWMVDTRISVRIHEYAAISLTACMENLVEEIRARVMASHSPDGGGAGGGEVSAEALEMVINNDAELWGVLQPYEHLICGKNANGN

--------------------------------------------------------------
>579_579_3_ABTB2-NDUFB1_ABTB2_chr11_34378248_ENST00000435224_NDUFB1_chr14_92582573_ENST00000553514_length(transcript)=1416nt_BP=1308nt
AGAAGTTTGCAGAGCGCTTTCTCGCCGGCTGGTCCCGGACTCGCGCTGCGCCCTGCGCCCTGCGCCGCCGCCTCCTCCTTCTGCCGCCGC
CGCCCTGTTCTCCCGGGATTCCTTCTCTGTGGAGGACTGACTCTCTGCTTGTGGGAATTAGAGGTGGACAAGGGGGAGTGCCGGGGGGTA
GCGACGGGGTTCTTTCCAGTGGCAGCTGCGAGTCGGGACGCCGGGAGCGTGGGGCTCCTGCTGGCCACGGATCTCGGCCACCTTCCCGCG
GCCTCCGGGCAGGCAATGCGGCCGCCGAGCCCCGCGACGCAGAGAGGAAGGAGGGTGGCCCGGAGGGCCTAGAGCTTGTTTCTGCCCACT
TGGGAAAGAGGGCATGGAGTTGTGAGTGCCCCTCGCTCGGCGACGCCGCCCTCGGCAGGCTCCCCATGGCCGGGACGTACAGCTCGACTC
TGAAGACGCTGGAGGACTTGACCTTGGACTCCGGGTATGGGGCCGGGGACTCGTGCCGCTCGCTCAGCCTCTCGTCCTCCAAGTCCAACT
CGCAGGCGCTCAACTCTTCGGCGCAGCAGCACCGCGGGGCGGCCTGGTGGTGCTACTCCGGCTCCATGAACAGCCGCCACAACAGCTGGG
ACACGGTGAACACGGTGCTGCCCGAGGACCCCGAAGTGGCCGACCTCTTCTCGCGCTGTCCGCGGCTCCCCGAGCTGGAGGAGTTCCCCT
GGACCGAAGGAGACGTGGCCCGGGTGCTCCGCAAAGGCGCTGGCGGCCGGCGGCTGCCCCAGTTCTCCGCCGAGGCGGTGAGGCGCCTGG
CCGGGCTGCTCCGCAGGGCACTGATCCGCGTGGCCCGCGAGGCGCAGCGCCTGAGCGTGCTGCACGCCAAGTGCACCCGCTTTGAGGTGC
AGAGCGCCGTGCGCCTGGTGCACAGCTGGGCGCTGGCCGAGAGCTGCGCGCTGGCAGCCGTCAAGGCGCTGTCCCTGTACAGCATGAGCG
CCGGCGACGGGCTGCGCCGGGGCAAGTCCGCGCGCTGCGGCCTCACCTTCTCAGTGGGTCGCTTTTTCCGCTGGATGGTGGACACCCGAA
TCTCCGTGCGCATCCACGAGTACGCAGCCATCTCCCTCACCGCCTGCATGGAGAACCTGGTGGAGGAGATCCGGGCCAGGGTGATGGCCA
GCCACAGCCCTGATGGCGGAGGGGCCGGAGGCGGGGAGGTGTCTGCTGAGGCCCTGGAGATGGTCATCAACAACGACGCCGAGCTCTGGG
GCGTCTTGCAGCCCTATGAGCATCTCATCTGCGGCAAGAACGCCAATGGGAATTGCAACCCAGTGAAGAAGTTACCTGGAAGTAAAGACT

>579_579_3_ABTB2-NDUFB1_ABTB2_chr11_34378248_ENST00000435224_NDUFB1_chr14_92582573_ENST00000553514_length(amino acids)=439AA_BP=416
MRRRLLLLPPPPCSPGIPSLWRTDSLLVGIRGGQGGVPGGSDGVLSSGSCESGRRERGAPAGHGSRPPSRGLRAGNAAAEPRDAERKEGG
PEGLELVSAHLGKRAWSCECPSLGDAALGRLPMAGTYSSTLKTLEDLTLDSGYGAGDSCRSLSLSSSKSNSQALNSSAQQHRGAAWWCYS
GSMNSRHNSWDTVNTVLPEDPEVADLFSRCPRLPELEEFPWTEGDVARVLRKGAGGRRLPQFSAEAVRRLAGLLRRALIRVAREAQRLSV
LHAKCTRFEVQSAVRLVHSWALAESCALAAVKALSLYSMSAGDGLRRGKSARCGLTFSVGRFFRWMVDTRISVRIHEYAAISLTACMENL

--------------------------------------------------------------
>579_579_4_ABTB2-NDUFB1_ABTB2_chr11_34378248_ENST00000435224_NDUFB1_chr14_92582573_ENST00000605997_length(transcript)=1413nt_BP=1308nt
AGAAGTTTGCAGAGCGCTTTCTCGCCGGCTGGTCCCGGACTCGCGCTGCGCCCTGCGCCCTGCGCCGCCGCCTCCTCCTTCTGCCGCCGC
CGCCCTGTTCTCCCGGGATTCCTTCTCTGTGGAGGACTGACTCTCTGCTTGTGGGAATTAGAGGTGGACAAGGGGGAGTGCCGGGGGGTA
GCGACGGGGTTCTTTCCAGTGGCAGCTGCGAGTCGGGACGCCGGGAGCGTGGGGCTCCTGCTGGCCACGGATCTCGGCCACCTTCCCGCG
GCCTCCGGGCAGGCAATGCGGCCGCCGAGCCCCGCGACGCAGAGAGGAAGGAGGGTGGCCCGGAGGGCCTAGAGCTTGTTTCTGCCCACT
TGGGAAAGAGGGCATGGAGTTGTGAGTGCCCCTCGCTCGGCGACGCCGCCCTCGGCAGGCTCCCCATGGCCGGGACGTACAGCTCGACTC
TGAAGACGCTGGAGGACTTGACCTTGGACTCCGGGTATGGGGCCGGGGACTCGTGCCGCTCGCTCAGCCTCTCGTCCTCCAAGTCCAACT
CGCAGGCGCTCAACTCTTCGGCGCAGCAGCACCGCGGGGCGGCCTGGTGGTGCTACTCCGGCTCCATGAACAGCCGCCACAACAGCTGGG
ACACGGTGAACACGGTGCTGCCCGAGGACCCCGAAGTGGCCGACCTCTTCTCGCGCTGTCCGCGGCTCCCCGAGCTGGAGGAGTTCCCCT
GGACCGAAGGAGACGTGGCCCGGGTGCTCCGCAAAGGCGCTGGCGGCCGGCGGCTGCCCCAGTTCTCCGCCGAGGCGGTGAGGCGCCTGG
CCGGGCTGCTCCGCAGGGCACTGATCCGCGTGGCCCGCGAGGCGCAGCGCCTGAGCGTGCTGCACGCCAAGTGCACCCGCTTTGAGGTGC
AGAGCGCCGTGCGCCTGGTGCACAGCTGGGCGCTGGCCGAGAGCTGCGCGCTGGCAGCCGTCAAGGCGCTGTCCCTGTACAGCATGAGCG
CCGGCGACGGGCTGCGCCGGGGCAAGTCCGCGCGCTGCGGCCTCACCTTCTCAGTGGGTCGCTTTTTCCGCTGGATGGTGGACACCCGAA
TCTCCGTGCGCATCCACGAGTACGCAGCCATCTCCCTCACCGCCTGCATGGAGAACCTGGTGGAGGAGATCCGGGCCAGGGTGATGGCCA
GCCACAGCCCTGATGGCGGAGGGGCCGGAGGCGGGGAGGTGTCTGCTGAGGCCCTGGAGATGGTCATCAACAACGACGCCGAGCTCTGGG
GCGTCTTGCAGCCCTATGAGCATCTCATCTGCGGCAAGAACGCCAATGGGAATTGCAACCCAGTGAAGAAGTTACCTGGAAGTAAAGACT

>579_579_4_ABTB2-NDUFB1_ABTB2_chr11_34378248_ENST00000435224_NDUFB1_chr14_92582573_ENST00000605997_length(amino acids)=439AA_BP=416
MRRRLLLLPPPPCSPGIPSLWRTDSLLVGIRGGQGGVPGGSDGVLSSGSCESGRRERGAPAGHGSRPPSRGLRAGNAAAEPRDAERKEGG
PEGLELVSAHLGKRAWSCECPSLGDAALGRLPMAGTYSSTLKTLEDLTLDSGYGAGDSCRSLSLSSSKSNSQALNSSAQQHRGAAWWCYS
GSMNSRHNSWDTVNTVLPEDPEVADLFSRCPRLPELEEFPWTEGDVARVLRKGAGGRRLPQFSAEAVRRLAGLLRRALIRVAREAQRLSV
LHAKCTRFEVQSAVRLVHSWALAESCALAAVKALSLYSMSAGDGLRRGKSARCGLTFSVGRFFRWMVDTRISVRIHEYAAISLTACMENL

--------------------------------------------------------------

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Fusion Gene PPI Analysis for ABTB2-NDUFB1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ABTB2-NDUFB1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneNDUFB1O75438DB00157NADHSmall moleculeApproved|Nutraceutical

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Related Diseases for ABTB2-NDUFB1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource