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in Kim Lab

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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:CHRDL2-COPB1 (FusionGDB2 ID:HG25884TG1315)

Fusion Gene Summary for CHRDL2-COPB1

check button Fusion gene summary
Fusion gene informationFusion gene name: CHRDL2-COPB1
Fusion gene ID: hg25884tg1315
HgeneTgene
Gene symbol

CHRDL2

COPB1

Gene ID

25884

1315

Gene namechordin like 2COPI coat complex subunit beta 1
SynonymsBNF1|CHL2COPB
Cytomap('CHRDL2')('COPB1')

11q13.4

11p15.2

Type of geneprotein-codingprotein-coding
Descriptionchordin-like protein 2breast tumor novel factor 1chordin-related protein 2coatomer subunit betabeta coat proteinbeta-copcoatomer protein complex subunit beta 1
Modification date2020031320200327
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000263671, ENST00000376332, 
ENST00000534159, 
Fusion gene scores* DoF score2 X 2 X 2=87 X 8 X 2=112
# samples 28
** MAII scorelog2(2/8*10)=1.32192809488736log2(8/112*10)=-0.485426827170242
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CHRDL2 [Title/Abstract] AND COPB1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCHRDL2(74429765)-COPB1(14491109), # samples:2
Anticipated loss of major functional domain due to fusion event.CHRDL2-COPB1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
CHRDL2-COPB1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across CHRDL2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across COPB1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-E2-A1IU-01ACHRDL2chr11

74429765

-COPB1chr11

14491109

-


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Fusion Gene ORF analysis for CHRDL2-COPB1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000263671ENST00000526191CHRDL2chr11

74429765

-COPB1chr11

14491109

-
5CDS-intronENST00000376332ENST00000526191CHRDL2chr11

74429765

-COPB1chr11

14491109

-
5UTR-3CDSENST00000534159ENST00000249923CHRDL2chr11

74429765

-COPB1chr11

14491109

-
5UTR-3CDSENST00000534159ENST00000439561CHRDL2chr11

74429765

-COPB1chr11

14491109

-
5UTR-intronENST00000534159ENST00000526191CHRDL2chr11

74429765

-COPB1chr11

14491109

-
In-frameENST00000263671ENST00000249923CHRDL2chr11

74429765

-COPB1chr11

14491109

-
In-frameENST00000263671ENST00000439561CHRDL2chr11

74429765

-COPB1chr11

14491109

-
In-frameENST00000376332ENST00000249923CHRDL2chr11

74429765

-COPB1chr11

14491109

-
In-frameENST00000376332ENST00000439561CHRDL2chr11

74429765

-COPB1chr11

14491109

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000263671CHRDL2chr1174429765-ENST00000249923COPB1chr1114491109-192548281606532
ENST00000263671CHRDL2chr1174429765-ENST00000439561COPB1chr1114491109-188148281606532
ENST00000376332CHRDL2chr1174429765-ENST00000249923COPB1chr1114491109-21356921491816555
ENST00000376332CHRDL2chr1174429765-ENST00000439561COPB1chr1114491109-20916921491816555

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000263671ENST00000249923CHRDL2chr1174429765-COPB1chr1114491109-0.0003555080.9996445
ENST00000263671ENST00000439561CHRDL2chr1174429765-COPB1chr1114491109-0.000428530.9995715
ENST00000376332ENST00000249923CHRDL2chr1174429765-COPB1chr1114491109-0.0005543170.9994456
ENST00000376332ENST00000439561CHRDL2chr1174429765-COPB1chr1114491109-0.0006635810.9993364

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Fusion Genomic Features for CHRDL2-COPB1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for CHRDL2-COPB1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr11:74429765/chr11:14491109)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCHRDL2chr11:74429765chr11:14491109ENST00000263671-212109_17565452.0DomainVWFC 2
HgeneCHRDL2chr11:74429765chr11:14491109ENST00000263671-212250_31565452.0DomainVWFC 3
HgeneCHRDL2chr11:74429765chr11:14491109ENST00000263671-21231_9665452.0DomainVWFC 1
HgeneCHRDL2chr11:74429765chr11:14491109ENST00000376332-211109_17565430.0DomainVWFC 2
HgeneCHRDL2chr11:74429765chr11:14491109ENST00000376332-211250_31565430.0DomainVWFC 3
HgeneCHRDL2chr11:74429765chr11:14491109ENST00000376332-21131_9665430.0DomainVWFC 1
TgeneCOPB1chr11:74429765chr11:14491109ENST000002499231322132_168579954.0RepeatNote=HEAT 2
TgeneCOPB1chr11:74429765chr11:14491109ENST000002499231322240_276579954.0RepeatNote=HEAT 3
TgeneCOPB1chr11:74429765chr11:14491109ENST000002499231322277_314579954.0RepeatNote=HEAT 4
TgeneCOPB1chr11:74429765chr11:14491109ENST000002499231322316_353579954.0RepeatNote=HEAT 5
TgeneCOPB1chr11:74429765chr11:14491109ENST000002499231322396_433579954.0RepeatNote=HEAT 6
TgeneCOPB1chr11:74429765chr11:14491109ENST00000249923132296_131579954.0RepeatNote=HEAT 1
TgeneCOPB1chr11:74429765chr11:14491109ENST000004395611322132_168579954.0RepeatNote=HEAT 2
TgeneCOPB1chr11:74429765chr11:14491109ENST000004395611322240_276579954.0RepeatNote=HEAT 3
TgeneCOPB1chr11:74429765chr11:14491109ENST000004395611322277_314579954.0RepeatNote=HEAT 4
TgeneCOPB1chr11:74429765chr11:14491109ENST000004395611322316_353579954.0RepeatNote=HEAT 5
TgeneCOPB1chr11:74429765chr11:14491109ENST000004395611322396_433579954.0RepeatNote=HEAT 6
TgeneCOPB1chr11:74429765chr11:14491109ENST00000439561132296_131579954.0RepeatNote=HEAT 1


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Fusion Gene Sequence for CHRDL2-COPB1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>16641_16641_1_CHRDL2-COPB1_CHRDL2_chr11_74429765_ENST00000263671_COPB1_chr11_14491109_ENST00000249923_length(transcript)=1925nt_BP=482nt
CCCTTTCTTTGATCGCCTCTCCCTTCTGCTGGACCTTCCTTCGTCTCTCCATCTCTCCCTCCTTTCCCCGCGTTCTCTTTCCACCTTTCT
CTTCTTCCCACCTTAGACCTCCCTTCCTGCCCTCCTTTCCTGCCCACCGCTGCTTCCTGGCCCTTCTCCGACCCCGCTCTAGCAGCAGAC
CTCCTGGGGTCTGTGGGTTGATCTGTGGCCCCTGTGCCTCCGTGTCCTTTTCGTCTCCCTTCCTCCCGACTCCGCTCCCGGACCAGCGGC
CTGACCCTGGGGAAAGGATGGTTCCCGAGGTGAGGGTCCTCTCCTCCTTGCTGGGACTCGCGCTGCTCTGGTTCCCCCTGGACTCCCACG
CTCGAGCCCGCCCAGACATGTTCTGCCTTTTCCATGGGAAGAGATACTCCCCCGGCGAGAGCTGGCACCCCTACTTGGAGCCACAAGGCC
TGATGTACTGCCTGCGCTGTACCTGCTCAGAGTCTTTTGTTGCTGAGGCTATGTTGCTCATGGCTACTATCCTGCATTTGGGAAAATCCT
CTCTTCCTAAGAAGCCAATTACTGATGATGATGTGGATCGAATTTCCCTGTGCCTCAAGGTCTTGTCTGAATGTTCACCTTTAATGAATG
ACATTTTCAATAAGGAATGCAGACAGTCCCTTTCTCACATGTTATCTGCTAAACTAGAAGAAGAGAAATTATCCCAAAAGAAAGAATCTG
AAAAGAGGAATGTGACAGTACAGCCTGATGACCCCATTTCCTTCATGCAACTAACTGCTAAGAATGAAATGAACTGCAAGGAAGATCAGT
TTCAGCTGAGTTTACTGGCAGCAATGGGTAACACACAGAGGAAAGAGGCAGCAGATCCCCTAGCATCTAAACTTAACAAGGTCACCCAAT
TGACAGGTTTCTCAGATCCTGTATATGCAGAAGCTTACGTTCATGTCAACCAATATGATATTGTCCTGGATGTACTTGTTGTGAACCAAA
CCAGTGATACTTTGCAGAATTGCACATTAGAACTAGCTACACTAGGGGATCTGAAACTTGTGGAAAAGCCGTCTCCTTTGACTCTTGCTC
CTCATGACTTCGCAAATATTAAAGCTAACGTCAAAGTAGCATCAACAGAAAATGGAATAATTTTTGGTAATATAGTTTATGATGTCTCTG
GAGCAGCAAGTGACAGAAATTGTGTGGTTCTCAGTGATATTCACATCGACATCATGGACTATATCCAGCCTGCAACTTGCACTGATGCAG
AATTCCGTCAGATGTGGGCCGAATTTGAATGGGAAAACAAAGTGACAGTTAACACCAACATGGTTGATTTAAATGACTACTTACAGCACA
TATTAAAGTCAACCAATATGAAATGCCTGACTCCAGAAAAGGCCCTTTCTGGTTACTGTGGCTTTATGGCAGCCAACCTTTATGCTCGTT
CCATATTTGGTGAAGATGCACTTGCAAATGTCAGCATTGAGAAGCCAATTCACCAGGGACCAGATGCTGCTGTTACCGGCCATATAAGAA
TTCGTGCAAAGAGCCAGGGAATGGCCTTAAGTCTTGGAGATAAAATCAACTTGTCACAGAAGAAAACTAGTATATAAAAATAAACAAAAA
GTCCTTGAAGCTTTACAGTTAATTTAGGTATGGGCTTACTGGACTCCAACATCTTTTGTACTCTTTCATGCTTATATAGAATCTGAGTTC
ATGCTGAATACTTTTCAGCCAATAATTTATAGCCTTTCCCTTAAATCAAGATTGAGTTTAAAATTATAGTTTGTCTTTTGTCTTAACAGT
TCTGAATGCTGTCCTCAAAGTATATAATGTTTCATGTACCAAGACCCTTTTCACAGTACAATAAACAGATCTATTCATAAATTTTTGTTA

>16641_16641_1_CHRDL2-COPB1_CHRDL2_chr11_74429765_ENST00000263671_COPB1_chr11_14491109_ENST00000249923_length(amino acids)=532AA_BP=156
MIASPFCWTFLRLSISPSFPRVLFPPFSSSHLRPPFLPSFPAHRCFLALLRPRSSSRPPGVCGLICGPCASVSFSSPFLPTPLPDQRPDP
GERMVPEVRVLSSLLGLALLWFPLDSHARARPDMFCLFHGKRYSPGESWHPYLEPQGLMYCLRCTCSESFVAEAMLLMATILHLGKSSLP
KKPITDDDVDRISLCLKVLSECSPLMNDIFNKECRQSLSHMLSAKLEEEKLSQKKESEKRNVTVQPDDPISFMQLTAKNEMNCKEDQFQL
SLLAAMGNTQRKEAADPLASKLNKVTQLTGFSDPVYAEAYVHVNQYDIVLDVLVVNQTSDTLQNCTLELATLGDLKLVEKPSPLTLAPHD
FANIKANVKVASTENGIIFGNIVYDVSGAASDRNCVVLSDIHIDIMDYIQPATCTDAEFRQMWAEFEWENKVTVNTNMVDLNDYLQHILK

--------------------------------------------------------------
>16641_16641_2_CHRDL2-COPB1_CHRDL2_chr11_74429765_ENST00000263671_COPB1_chr11_14491109_ENST00000439561_length(transcript)=1881nt_BP=482nt
CCCTTTCTTTGATCGCCTCTCCCTTCTGCTGGACCTTCCTTCGTCTCTCCATCTCTCCCTCCTTTCCCCGCGTTCTCTTTCCACCTTTCT
CTTCTTCCCACCTTAGACCTCCCTTCCTGCCCTCCTTTCCTGCCCACCGCTGCTTCCTGGCCCTTCTCCGACCCCGCTCTAGCAGCAGAC
CTCCTGGGGTCTGTGGGTTGATCTGTGGCCCCTGTGCCTCCGTGTCCTTTTCGTCTCCCTTCCTCCCGACTCCGCTCCCGGACCAGCGGC
CTGACCCTGGGGAAAGGATGGTTCCCGAGGTGAGGGTCCTCTCCTCCTTGCTGGGACTCGCGCTGCTCTGGTTCCCCCTGGACTCCCACG
CTCGAGCCCGCCCAGACATGTTCTGCCTTTTCCATGGGAAGAGATACTCCCCCGGCGAGAGCTGGCACCCCTACTTGGAGCCACAAGGCC
TGATGTACTGCCTGCGCTGTACCTGCTCAGAGTCTTTTGTTGCTGAGGCTATGTTGCTCATGGCTACTATCCTGCATTTGGGAAAATCCT
CTCTTCCTAAGAAGCCAATTACTGATGATGATGTGGATCGAATTTCCCTGTGCCTCAAGGTCTTGTCTGAATGTTCACCTTTAATGAATG
ACATTTTCAATAAGGAATGCAGACAGTCCCTTTCTCACATGTTATCTGCTAAACTAGAAGAAGAGAAATTATCCCAAAAGAAAGAATCTG
AAAAGAGGAATGTGACAGTACAGCCTGATGACCCCATTTCCTTCATGCAACTAACTGCTAAGAATGAAATGAACTGCAAGGAAGATCAGT
TTCAGCTGAGTTTACTGGCAGCAATGGGTAACACACAGAGGAAAGAGGCAGCAGATCCCCTAGCATCTAAACTTAACAAGGTCACCCAAT
TGACAGGTTTCTCAGATCCTGTATATGCAGAAGCTTACGTTCATGTCAACCAATATGATATTGTCCTGGATGTACTTGTTGTGAACCAAA
CCAGTGATACTTTGCAGAATTGCACATTAGAACTAGCTACACTAGGGGATCTGAAACTTGTGGAAAAGCCGTCTCCTTTGACTCTTGCTC
CTCATGACTTCGCAAATATTAAAGCTAACGTCAAAGTAGCATCAACAGAAAATGGAATAATTTTTGGTAATATAGTTTATGATGTCTCTG
GAGCAGCAAGTGACAGAAATTGTGTGGTTCTCAGTGATATTCACATCGACATCATGGACTATATCCAGCCTGCAACTTGCACTGATGCAG
AATTCCGTCAGATGTGGGCCGAATTTGAATGGGAAAACAAAGTGACAGTTAACACCAACATGGTTGATTTAAATGACTACTTACAGCACA
TATTAAAGTCAACCAATATGAAATGCCTGACTCCAGAAAAGGCCCTTTCTGGTTACTGTGGCTTTATGGCAGCCAACCTTTATGCTCGTT
CCATATTTGGTGAAGATGCACTTGCAAATGTCAGCATTGAGAAGCCAATTCACCAGGGACCAGATGCTGCTGTTACCGGCCATATAAGAA
TTCGTGCAAAGAGCCAGGGAATGGCCTTAAGTCTTGGAGATAAAATCAACTTGTCACAGAAGAAAACTAGTATATAAAAATAAACAAAAA
GTCCTTGAAGCTTTACAGTTAATTTAGGTATGGGCTTACTGGACTCCAACATCTTTTGTACTCTTTCATGCTTATATAGAATCTGAGTTC
ATGCTGAATACTTTTCAGCCAATAATTTATAGCCTTTCCCTTAAATCAAGATTGAGTTTAAAATTATAGTTTGTCTTTTGTCTTAACAGT

>16641_16641_2_CHRDL2-COPB1_CHRDL2_chr11_74429765_ENST00000263671_COPB1_chr11_14491109_ENST00000439561_length(amino acids)=532AA_BP=156
MIASPFCWTFLRLSISPSFPRVLFPPFSSSHLRPPFLPSFPAHRCFLALLRPRSSSRPPGVCGLICGPCASVSFSSPFLPTPLPDQRPDP
GERMVPEVRVLSSLLGLALLWFPLDSHARARPDMFCLFHGKRYSPGESWHPYLEPQGLMYCLRCTCSESFVAEAMLLMATILHLGKSSLP
KKPITDDDVDRISLCLKVLSECSPLMNDIFNKECRQSLSHMLSAKLEEEKLSQKKESEKRNVTVQPDDPISFMQLTAKNEMNCKEDQFQL
SLLAAMGNTQRKEAADPLASKLNKVTQLTGFSDPVYAEAYVHVNQYDIVLDVLVVNQTSDTLQNCTLELATLGDLKLVEKPSPLTLAPHD
FANIKANVKVASTENGIIFGNIVYDVSGAASDRNCVVLSDIHIDIMDYIQPATCTDAEFRQMWAEFEWENKVTVNTNMVDLNDYLQHILK

--------------------------------------------------------------
>16641_16641_3_CHRDL2-COPB1_CHRDL2_chr11_74429765_ENST00000376332_COPB1_chr11_14491109_ENST00000249923_length(transcript)=2135nt_BP=692nt
GCCGCCGCGCCGCCGCCGCTGCTGGGACCGCCGCCCCGCCGGGCCCCAGGCCCCCGCGGCCCGACCCCGAGCCCACCGAGCAGGGGGCGC
CGGCCGCCTCTAGCCCGCGCGCCCGCAACACCCGCTGGTCCCGCGCGCCTCGCCCGGCGCTGCGCGCTCGGCAGACGCCGGTCCTCTCCC
TGCTTTCTCCTCCTCTCCCTCTCACCTTCCCCCTTTCTTTGATCGCCTCTCCCTTCTGCTGGACCTTCCTTCGTCTCTCCATCTCTCCCT
CCTTTCCCCGCGTTCTCTTTCCACCTTTCTCTTCTTCCCACCTTAGACCTCCCTTCCTGCCCTCCTTTCCTGCCCACCGCTGCTTCCTGG
CCCTTCTCCGACCCCGCTCTAGCAGCAGACCTCCTGGGGTCTGTGGGTTGATCTGTGGCCCCTGTGCCTCCGTGTCCTTTTCGTCTCCCT
TCCTCCCGACTCCGCTCCCGGACCAGCGGCCTGACCCTGGGGAAAGGATGGTTCCCGAGGTGAGGGTCCTCTCCTCCTTGCTGGGACTCG
CGCTGCTCTGGTTCCCCCTGGACTCCCACGCTCGAGCCCGCCCAGACATGTTCTGCCTTTTCCATGGGAAGAGATACTCCCCCGGCGAGA
GCTGGCACCCCTACTTGGAGCCACAAGGCCTGATGTACTGCCTGCGCTGTACCTGCTCAGAGTCTTTTGTTGCTGAGGCTATGTTGCTCA
TGGCTACTATCCTGCATTTGGGAAAATCCTCTCTTCCTAAGAAGCCAATTACTGATGATGATGTGGATCGAATTTCCCTGTGCCTCAAGG
TCTTGTCTGAATGTTCACCTTTAATGAATGACATTTTCAATAAGGAATGCAGACAGTCCCTTTCTCACATGTTATCTGCTAAACTAGAAG
AAGAGAAATTATCCCAAAAGAAAGAATCTGAAAAGAGGAATGTGACAGTACAGCCTGATGACCCCATTTCCTTCATGCAACTAACTGCTA
AGAATGAAATGAACTGCAAGGAAGATCAGTTTCAGCTGAGTTTACTGGCAGCAATGGGTAACACACAGAGGAAAGAGGCAGCAGATCCCC
TAGCATCTAAACTTAACAAGGTCACCCAATTGACAGGTTTCTCAGATCCTGTATATGCAGAAGCTTACGTTCATGTCAACCAATATGATA
TTGTCCTGGATGTACTTGTTGTGAACCAAACCAGTGATACTTTGCAGAATTGCACATTAGAACTAGCTACACTAGGGGATCTGAAACTTG
TGGAAAAGCCGTCTCCTTTGACTCTTGCTCCTCATGACTTCGCAAATATTAAAGCTAACGTCAAAGTAGCATCAACAGAAAATGGAATAA
TTTTTGGTAATATAGTTTATGATGTCTCTGGAGCAGCAAGTGACAGAAATTGTGTGGTTCTCAGTGATATTCACATCGACATCATGGACT
ATATCCAGCCTGCAACTTGCACTGATGCAGAATTCCGTCAGATGTGGGCCGAATTTGAATGGGAAAACAAAGTGACAGTTAACACCAACA
TGGTTGATTTAAATGACTACTTACAGCACATATTAAAGTCAACCAATATGAAATGCCTGACTCCAGAAAAGGCCCTTTCTGGTTACTGTG
GCTTTATGGCAGCCAACCTTTATGCTCGTTCCATATTTGGTGAAGATGCACTTGCAAATGTCAGCATTGAGAAGCCAATTCACCAGGGAC
CAGATGCTGCTGTTACCGGCCATATAAGAATTCGTGCAAAGAGCCAGGGAATGGCCTTAAGTCTTGGAGATAAAATCAACTTGTCACAGA
AGAAAACTAGTATATAAAAATAAACAAAAAGTCCTTGAAGCTTTACAGTTAATTTAGGTATGGGCTTACTGGACTCCAACATCTTTTGTA
CTCTTTCATGCTTATATAGAATCTGAGTTCATGCTGAATACTTTTCAGCCAATAATTTATAGCCTTTCCCTTAAATCAAGATTGAGTTTA
AAATTATAGTTTGTCTTTTGTCTTAACAGTTCTGAATGCTGTCCTCAAAGTATATAATGTTTCATGTACCAAGACCCTTTTCACAGTACA

>16641_16641_3_CHRDL2-COPB1_CHRDL2_chr11_74429765_ENST00000376332_COPB1_chr11_14491109_ENST00000249923_length(amino acids)=555AA_BP=179
MRARQTPVLSLLSPPLPLTFPLSLIASPFCWTFLRLSISPSFPRVLFPPFSSSHLRPPFLPSFPAHRCFLALLRPRSSSRPPGVCGLICG
PCASVSFSSPFLPTPLPDQRPDPGERMVPEVRVLSSLLGLALLWFPLDSHARARPDMFCLFHGKRYSPGESWHPYLEPQGLMYCLRCTCS
ESFVAEAMLLMATILHLGKSSLPKKPITDDDVDRISLCLKVLSECSPLMNDIFNKECRQSLSHMLSAKLEEEKLSQKKESEKRNVTVQPD
DPISFMQLTAKNEMNCKEDQFQLSLLAAMGNTQRKEAADPLASKLNKVTQLTGFSDPVYAEAYVHVNQYDIVLDVLVVNQTSDTLQNCTL
ELATLGDLKLVEKPSPLTLAPHDFANIKANVKVASTENGIIFGNIVYDVSGAASDRNCVVLSDIHIDIMDYIQPATCTDAEFRQMWAEFE
WENKVTVNTNMVDLNDYLQHILKSTNMKCLTPEKALSGYCGFMAANLYARSIFGEDALANVSIEKPIHQGPDAAVTGHIRIRAKSQGMAL

--------------------------------------------------------------
>16641_16641_4_CHRDL2-COPB1_CHRDL2_chr11_74429765_ENST00000376332_COPB1_chr11_14491109_ENST00000439561_length(transcript)=2091nt_BP=692nt
GCCGCCGCGCCGCCGCCGCTGCTGGGACCGCCGCCCCGCCGGGCCCCAGGCCCCCGCGGCCCGACCCCGAGCCCACCGAGCAGGGGGCGC
CGGCCGCCTCTAGCCCGCGCGCCCGCAACACCCGCTGGTCCCGCGCGCCTCGCCCGGCGCTGCGCGCTCGGCAGACGCCGGTCCTCTCCC
TGCTTTCTCCTCCTCTCCCTCTCACCTTCCCCCTTTCTTTGATCGCCTCTCCCTTCTGCTGGACCTTCCTTCGTCTCTCCATCTCTCCCT
CCTTTCCCCGCGTTCTCTTTCCACCTTTCTCTTCTTCCCACCTTAGACCTCCCTTCCTGCCCTCCTTTCCTGCCCACCGCTGCTTCCTGG
CCCTTCTCCGACCCCGCTCTAGCAGCAGACCTCCTGGGGTCTGTGGGTTGATCTGTGGCCCCTGTGCCTCCGTGTCCTTTTCGTCTCCCT
TCCTCCCGACTCCGCTCCCGGACCAGCGGCCTGACCCTGGGGAAAGGATGGTTCCCGAGGTGAGGGTCCTCTCCTCCTTGCTGGGACTCG
CGCTGCTCTGGTTCCCCCTGGACTCCCACGCTCGAGCCCGCCCAGACATGTTCTGCCTTTTCCATGGGAAGAGATACTCCCCCGGCGAGA
GCTGGCACCCCTACTTGGAGCCACAAGGCCTGATGTACTGCCTGCGCTGTACCTGCTCAGAGTCTTTTGTTGCTGAGGCTATGTTGCTCA
TGGCTACTATCCTGCATTTGGGAAAATCCTCTCTTCCTAAGAAGCCAATTACTGATGATGATGTGGATCGAATTTCCCTGTGCCTCAAGG
TCTTGTCTGAATGTTCACCTTTAATGAATGACATTTTCAATAAGGAATGCAGACAGTCCCTTTCTCACATGTTATCTGCTAAACTAGAAG
AAGAGAAATTATCCCAAAAGAAAGAATCTGAAAAGAGGAATGTGACAGTACAGCCTGATGACCCCATTTCCTTCATGCAACTAACTGCTA
AGAATGAAATGAACTGCAAGGAAGATCAGTTTCAGCTGAGTTTACTGGCAGCAATGGGTAACACACAGAGGAAAGAGGCAGCAGATCCCC
TAGCATCTAAACTTAACAAGGTCACCCAATTGACAGGTTTCTCAGATCCTGTATATGCAGAAGCTTACGTTCATGTCAACCAATATGATA
TTGTCCTGGATGTACTTGTTGTGAACCAAACCAGTGATACTTTGCAGAATTGCACATTAGAACTAGCTACACTAGGGGATCTGAAACTTG
TGGAAAAGCCGTCTCCTTTGACTCTTGCTCCTCATGACTTCGCAAATATTAAAGCTAACGTCAAAGTAGCATCAACAGAAAATGGAATAA
TTTTTGGTAATATAGTTTATGATGTCTCTGGAGCAGCAAGTGACAGAAATTGTGTGGTTCTCAGTGATATTCACATCGACATCATGGACT
ATATCCAGCCTGCAACTTGCACTGATGCAGAATTCCGTCAGATGTGGGCCGAATTTGAATGGGAAAACAAAGTGACAGTTAACACCAACA
TGGTTGATTTAAATGACTACTTACAGCACATATTAAAGTCAACCAATATGAAATGCCTGACTCCAGAAAAGGCCCTTTCTGGTTACTGTG
GCTTTATGGCAGCCAACCTTTATGCTCGTTCCATATTTGGTGAAGATGCACTTGCAAATGTCAGCATTGAGAAGCCAATTCACCAGGGAC
CAGATGCTGCTGTTACCGGCCATATAAGAATTCGTGCAAAGAGCCAGGGAATGGCCTTAAGTCTTGGAGATAAAATCAACTTGTCACAGA
AGAAAACTAGTATATAAAAATAAACAAAAAGTCCTTGAAGCTTTACAGTTAATTTAGGTATGGGCTTACTGGACTCCAACATCTTTTGTA
CTCTTTCATGCTTATATAGAATCTGAGTTCATGCTGAATACTTTTCAGCCAATAATTTATAGCCTTTCCCTTAAATCAAGATTGAGTTTA
AAATTATAGTTTGTCTTTTGTCTTAACAGTTCTGAATGCTGTCCTCAAAGTATATAATGTTTCATGTACCAAGACCCTTTTCACAGTACA

>16641_16641_4_CHRDL2-COPB1_CHRDL2_chr11_74429765_ENST00000376332_COPB1_chr11_14491109_ENST00000439561_length(amino acids)=555AA_BP=179
MRARQTPVLSLLSPPLPLTFPLSLIASPFCWTFLRLSISPSFPRVLFPPFSSSHLRPPFLPSFPAHRCFLALLRPRSSSRPPGVCGLICG
PCASVSFSSPFLPTPLPDQRPDPGERMVPEVRVLSSLLGLALLWFPLDSHARARPDMFCLFHGKRYSPGESWHPYLEPQGLMYCLRCTCS
ESFVAEAMLLMATILHLGKSSLPKKPITDDDVDRISLCLKVLSECSPLMNDIFNKECRQSLSHMLSAKLEEEKLSQKKESEKRNVTVQPD
DPISFMQLTAKNEMNCKEDQFQLSLLAAMGNTQRKEAADPLASKLNKVTQLTGFSDPVYAEAYVHVNQYDIVLDVLVVNQTSDTLQNCTL
ELATLGDLKLVEKPSPLTLAPHDFANIKANVKVASTENGIIFGNIVYDVSGAASDRNCVVLSDIHIDIMDYIQPATCTDAEFRQMWAEFE
WENKVTVNTNMVDLNDYLQHILKSTNMKCLTPEKALSGYCGFMAANLYARSIFGEDALANVSIEKPIHQGPDAAVTGHIRIRAKSQGMAL

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Fusion Gene PPI Analysis for CHRDL2-COPB1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for CHRDL2-COPB1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for CHRDL2-COPB1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource