Fusion Gene Studies
in Kim Lab

FusionBase FusionGDB FusionGDB2 FusionPDB FusionNeoAntigen FusionAI FusionNW FGviewer Publication Contact
FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:ABI3BP-ESYT2 (FusionGDB2 ID:HG25890TG57488)

Fusion Gene Summary for ABI3BP-ESYT2

check button Fusion gene summary
Fusion gene informationFusion gene name: ABI3BP-ESYT2
Fusion gene ID: hg25890tg57488
HgeneTgene
Gene symbol

ABI3BP

ESYT2

Gene ID

25890

57488

Gene nameABI family member 3 binding proteinextended synaptotagmin 2
SynonymsNESHBP|TARSHCHR2SYT|E-Syt2|FAM62B
Cytomap('ABI3BP')('ESYT2')

3q12.2

7q36.3

Type of geneprotein-codingprotein-coding
Descriptiontarget of Nesh-SH3ABI family, member 3 (NESH) binding proteinABI gene family member 3-binding proteinABI gene family, member 3 (NESH) binding proteinnesh-binding proteinextended synaptotagmin-2chr2 synaptotagminextended synaptotagmin like protein 2extended synaptotagmin protein 2family with sequence similarity 62 (C2 domain containing), member B
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000383691, ENST00000471714, 
ENST00000495063, ENST00000284322, 
ENST00000532144, 
Fusion gene scores* DoF score4 X 4 X 4=6412 X 12 X 6=864
# samples 413
** MAII scorelog2(4/64*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(13/864*10)=-2.73251968913501
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ABI3BP [Title/Abstract] AND ESYT2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointABI3BP(100553528)-ESYT2(158527162), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID


check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-BR-A4J5-01AABI3BPchr3

100553528

-ESYT2chr7

158527162

-


Top

Fusion Gene ORF analysis for ABI3BP-ESYT2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000383691ENST00000435514ABI3BPchr3

100553528

-ESYT2chr7

158527162

-
5CDS-intronENST00000383691ENST00000497111ABI3BPchr3

100553528

-ESYT2chr7

158527162

-
5CDS-intronENST00000471714ENST00000435514ABI3BPchr3

100553528

-ESYT2chr7

158527162

-
5CDS-intronENST00000471714ENST00000497111ABI3BPchr3

100553528

-ESYT2chr7

158527162

-
5CDS-intronENST00000495063ENST00000435514ABI3BPchr3

100553528

-ESYT2chr7

158527162

-
5CDS-intronENST00000495063ENST00000497111ABI3BPchr3

100553528

-ESYT2chr7

158527162

-
Frame-shiftENST00000383691ENST00000251527ABI3BPchr3

100553528

-ESYT2chr7

158527162

-
Frame-shiftENST00000471714ENST00000251527ABI3BPchr3

100553528

-ESYT2chr7

158527162

-
Frame-shiftENST00000495063ENST00000251527ABI3BPchr3

100553528

-ESYT2chr7

158527162

-
intron-3CDSENST00000284322ENST00000251527ABI3BPchr3

100553528

-ESYT2chr7

158527162

-
intron-3CDSENST00000532144ENST00000251527ABI3BPchr3

100553528

-ESYT2chr7

158527162

-
intron-intronENST00000284322ENST00000435514ABI3BPchr3

100553528

-ESYT2chr7

158527162

-
intron-intronENST00000284322ENST00000497111ABI3BPchr3

100553528

-ESYT2chr7

158527162

-
intron-intronENST00000532144ENST00000435514ABI3BPchr3

100553528

-ESYT2chr7

158527162

-
intron-intronENST00000532144ENST00000497111ABI3BPchr3

100553528

-ESYT2chr7

158527162

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

Top

Fusion Genomic Features for ABI3BP-ESYT2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)


Top

Fusion Protein Features for ABI3BP-ESYT2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:100553528/:158527162)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

Fusion Gene Sequence for ABI3BP-ESYT2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

Top

Fusion Gene PPI Analysis for ABI3BP-ESYT2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for ABI3BP-ESYT2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for ABI3BP-ESYT2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneABI3BPC0014175Endometriosis1CTD_human
HgeneABI3BPC0041696Unipolar Depression1PSYGENET
HgeneABI3BPC0269102Endometrioma1CTD_human
HgeneABI3BPC1269683Major Depressive Disorder1PSYGENET