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in Kim Lab

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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ANAPC15-TEX40 (FusionGDB2 ID:HG25906TG25858)

Fusion Gene Summary for ANAPC15-TEX40

check button Fusion gene summary
Fusion gene informationFusion gene name: ANAPC15-TEX40
Fusion gene ID: hg25906tg25858
HgeneTgene
Gene symbol

ANAPC15

TEX40

Gene ID

25906

25858

Gene nameanaphase promoting complex subunit 15catsper channel auxiliary subunit zeta
SynonymsAPC15|C11orf51|HSPC020C11orf20|TEX40
Cytomap('ANAPC15')('TEX40')

11q13.4

11q13.1

Type of geneprotein-codingprotein-coding
Descriptionanaphase-promoting complex subunit 15cation channel sperm-associated protein subunit zetacatSper-zetacatSperzetatestis expressed 40testis-expressed protein 40testis-expressed sequence 40 protein
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000543015, ENST00000227618, 
ENST00000502597, ENST00000535234, 
ENST00000535503, ENST00000538393, 
ENST00000538919, ENST00000542531, 
ENST00000543050, ENST00000543587, 
ENST00000545680, ENST00000545944, 
Fusion gene scores* DoF score2 X 1 X 2=45 X 3 X 3=45
# samples 24
** MAII scorelog2(2/4*10)=2.32192809488736log2(4/45*10)=-0.169925001442312
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ANAPC15 [Title/Abstract] AND TEX40 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointANAPC15(71821134)-TEX40(64072015), # samples:1
Anticipated loss of major functional domain due to fusion event.ANAPC15-TEX40 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ANAPC15-TEX40 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ANAPC15-TEX40 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
ANAPC15-TEX40 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across ANAPC15 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across TEX40 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-BH-A18H-01AANAPC15chr11

71821134

-TEX40chr11

64072015

+


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Fusion Gene ORF analysis for ANAPC15-TEX40

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000543015ENST00000328404ANAPC15chr11

71821134

-TEX40chr11

64072015

+
5UTR-3CDSENST00000543015ENST00000539943ANAPC15chr11

71821134

-TEX40chr11

64072015

+
Frame-shiftENST00000227618ENST00000539943ANAPC15chr11

71821134

-TEX40chr11

64072015

+
Frame-shiftENST00000502597ENST00000539943ANAPC15chr11

71821134

-TEX40chr11

64072015

+
Frame-shiftENST00000535234ENST00000539943ANAPC15chr11

71821134

-TEX40chr11

64072015

+
Frame-shiftENST00000535503ENST00000328404ANAPC15chr11

71821134

-TEX40chr11

64072015

+
Frame-shiftENST00000535503ENST00000539943ANAPC15chr11

71821134

-TEX40chr11

64072015

+
Frame-shiftENST00000538393ENST00000328404ANAPC15chr11

71821134

-TEX40chr11

64072015

+
Frame-shiftENST00000538393ENST00000539943ANAPC15chr11

71821134

-TEX40chr11

64072015

+
Frame-shiftENST00000538919ENST00000539943ANAPC15chr11

71821134

-TEX40chr11

64072015

+
Frame-shiftENST00000542531ENST00000539943ANAPC15chr11

71821134

-TEX40chr11

64072015

+
Frame-shiftENST00000543050ENST00000328404ANAPC15chr11

71821134

-TEX40chr11

64072015

+
Frame-shiftENST00000543050ENST00000539943ANAPC15chr11

71821134

-TEX40chr11

64072015

+
Frame-shiftENST00000543587ENST00000328404ANAPC15chr11

71821134

-TEX40chr11

64072015

+
Frame-shiftENST00000543587ENST00000539943ANAPC15chr11

71821134

-TEX40chr11

64072015

+
Frame-shiftENST00000545680ENST00000539943ANAPC15chr11

71821134

-TEX40chr11

64072015

+
Frame-shiftENST00000545944ENST00000328404ANAPC15chr11

71821134

-TEX40chr11

64072015

+
In-frameENST00000227618ENST00000328404ANAPC15chr11

71821134

-TEX40chr11

64072015

+
In-frameENST00000502597ENST00000328404ANAPC15chr11

71821134

-TEX40chr11

64072015

+
In-frameENST00000535234ENST00000328404ANAPC15chr11

71821134

-TEX40chr11

64072015

+
In-frameENST00000538919ENST00000328404ANAPC15chr11

71821134

-TEX40chr11

64072015

+
In-frameENST00000542531ENST00000328404ANAPC15chr11

71821134

-TEX40chr11

64072015

+
In-frameENST00000545680ENST00000328404ANAPC15chr11

71821134

-TEX40chr11

64072015

+
In-frameENST00000545944ENST00000539943ANAPC15chr11

71821134

-TEX40chr11

64072015

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000502597ANAPC15chr1171821134-ENST00000328404TEX40chr1164072015+477253726485
ENST00000545680ANAPC15chr1171821134-ENST00000328404TEX40chr1164072015+742518200529109
ENST00000227618ANAPC15chr1171821134-ENST00000328404TEX40chr1164072015+768544226555109
ENST00000542531ANAPC15chr1171821134-ENST00000328404TEX40chr1164072015+696472154483109
ENST00000535234ANAPC15chr1171821134-ENST00000328404TEX40chr1164072015+732508190519109
ENST00000545944ANAPC15chr1171821134-ENST00000539943TEX40chr1164072015+59336547376109
ENST00000538919ANAPC15chr1171821134-ENST00000328404TEX40chr1164072015+946722404733109

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000502597ENST00000328404ANAPC15chr1171821134-TEX40chr1164072015+0.50121440.49878556
ENST00000545680ENST00000328404ANAPC15chr1171821134-TEX40chr1164072015+0.0064465020.9935535
ENST00000227618ENST00000328404ANAPC15chr1171821134-TEX40chr1164072015+0.0073170510.992683
ENST00000542531ENST00000328404ANAPC15chr1171821134-TEX40chr1164072015+0.0090640490.990936
ENST00000535234ENST00000328404ANAPC15chr1171821134-TEX40chr1164072015+0.0080994640.99190056
ENST00000545944ENST00000539943ANAPC15chr1171821134-TEX40chr1164072015+0.0032983610.99670166
ENST00000538919ENST00000328404ANAPC15chr1171821134-TEX40chr1164072015+0.0189083220.98109174

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Fusion Genomic Features for ANAPC15-TEX40


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
ANAPC15chr1171821133-TEX40chr1164072014+5.83E-070.9999994
ANAPC15chr1171821133-TEX40chr1164072014+5.83E-070.9999994

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for ANAPC15-TEX40


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr11:71821134/chr11:64072015)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneANAPC15chr11:71821134chr11:64072015ENST00000227618-5663_117106122.0Compositional biasNote=Asp-rich
HgeneANAPC15chr11:71821134chr11:64072015ENST00000535234-5663_117106122.0Compositional biasNote=Asp-rich
HgeneANAPC15chr11:71821134chr11:64072015ENST00000535503-5663_117106122.0Compositional biasNote=Asp-rich
HgeneANAPC15chr11:71821134chr11:64072015ENST00000538393-5663_117106122.0Compositional biasNote=Asp-rich
HgeneANAPC15chr11:71821134chr11:64072015ENST00000538919-5663_117106122.0Compositional biasNote=Asp-rich
HgeneANAPC15chr11:71821134chr11:64072015ENST00000542531-5663_117106122.0Compositional biasNote=Asp-rich
HgeneANAPC15chr11:71821134chr11:64072015ENST00000543587-5663_117106126.0Compositional biasNote=Asp-rich
HgeneANAPC15chr11:71821134chr11:64072015ENST00000545680-5663_117106126.0Compositional biasNote=Asp-rich
HgeneANAPC15chr11:71821134chr11:64072015ENST00000545944-4563_117106122.0Compositional biasNote=Asp-rich


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Fusion Gene Sequence for ANAPC15-TEX40


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>4275_4275_1_ANAPC15-TEX40_ANAPC15_chr11_71821134_ENST00000227618_TEX40_chr11_64072015_ENST00000328404_length(transcript)=768nt_BP=544nt
GGGCGGGAGCGGGGAAAACAAAAGGAGACGAAGGACGCATGCGTTTGGTGAGTCCCGGATTCTGGTGGGTTCTTCCGCTCAGGCTGGGTG
AAGCGCTTCCGGGTCGCCGCCGGCAGCAGCCTCCCGGCGCGATGAAGACACTGAGGCTCAGAGAGGTTAAGTGACTCAGCCAAGGTCAAA
CAGCTAGTAAGTGGTGGAGCCAGGACTCAAAGCCAGTCTAGGAGCCATGTCCACTTTGTTCCCCTCACTCTTCCCTCGTGTGACTGAGAC
TCTGTGGTTTAATCTGGATCGACCCTGTGTGGAAGAGACAGAGCTGCAGCAGCAGGAACAGCAGCATCAGGCCTGGCTCCAAAGCATCGC
GGAGAAAGACAACAACCTGGTTCCTATTGGCAAGCCAGCCTCAGAGCACTATGATGACGAGGAAGAAGAGGATGATGAAGATGATGAGGA
TAGTGAAGAGGACTCAGAGGATGATGAGGATATGCAGGACATGGACGAGATGAATGACTACAATGAGTCACCGGATGATGGAGAGGTCAA
TGAGGCTACCAGTTAGGGATCGGCAGGGACCACTTCCTGACTAAGGAGCTGCAGCGATACATCGAAGGGCTCAAGAAGCGCCGGAGCAAG
AGGCTGTACGTGAATTAAAAACGCCACCTTGGGCTCGAGCAGCGACCCGAACCAGCCCCGTGCCAGCCCGGTCCCCAGACCCAAGCCTGA

>4275_4275_1_ANAPC15-TEX40_ANAPC15_chr11_71821134_ENST00000227618_TEX40_chr11_64072015_ENST00000328404_length(amino acids)=109AA_BP=
MSTLFPSLFPRVTETLWFNLDRPCVEETELQQQEQQHQAWLQSIAEKDNNLVPIGKPASEHYDDEEEEDDEDDEDSEEDSEDDEDMQDMD

--------------------------------------------------------------
>4275_4275_2_ANAPC15-TEX40_ANAPC15_chr11_71821134_ENST00000502597_TEX40_chr11_64072015_ENST00000328404_length(transcript)=477nt_BP=253nt
GCTCAGGCTGGGTGAAGCGCTTCCGGGTCGCCGCCGGCAGCAGCCTCCCGGCGCGCTCCAAAGCATCGCGGAGAAAGACAACAACCTGGT
TCCTATTGGCAAGCCAGCCTCAGAGCACTATGATGACGAGGAAGAAGAGGATGATGAAGATGATGAGGATAGTGAAGAGGACTCAGAGGA
TGATGAGGATATGCAGGACATGGACGAGATGAATGACTACAATGAGTCACCGGATGATGGAGAGGTCAATGAGGCTACCAGTTAGGGATC
GGCAGGGACCACTTCCTGACTAAGGAGCTGCAGCGATACATCGAAGGGCTCAAGAAGCGCCGGAGCAAGAGGCTGTACGTGAATTAAAAA
CGCCACCTTGGGCTCGAGCAGCGACCCGAACCAGCCCCGTGCCAGCCCGGTCCCCAGACCCAAGCCTGACCCCATCCGAGTGGAATTTGA

>4275_4275_2_ANAPC15-TEX40_ANAPC15_chr11_71821134_ENST00000502597_TEX40_chr11_64072015_ENST00000328404_length(amino acids)=85AA_BP=

--------------------------------------------------------------
>4275_4275_3_ANAPC15-TEX40_ANAPC15_chr11_71821134_ENST00000535234_TEX40_chr11_64072015_ENST00000328404_length(transcript)=732nt_BP=508nt
GAGCGGGGAAAACAAAAGGAGACGAAGGACGCATGCGTTTGGTGAGTCCCGGATTCTGGTGGGTTCTTCCGCTCAGGCTGGGTGAAGCGC
TTCCGGGTCGCCGCCGGCAGCAGCCTCCCGGCGCGATGAAGACACTGAGGCTCAGAGAGGTTAAGTGACTCAGCCAAGGTCAAACAGCTA
TCTAGGAGCCATGTCCACTTTGTTCCCCTCACTCTTCCCTCGTGTGACTGAGACTCTGTGGTTTAATCTGGATCGACCCTGTGTGGAAGA
GACAGAGCTGCAGCAGCAGGAACAGCAGCATCAGGCCTGGCTCCAAAGCATCGCGGAGAAAGACAACAACCTGGTTCCTATTGGCAAGCC
AGCCTCAGAGCACTATGATGACGAGGAAGAAGAGGATGATGAAGATGATGAGGATAGTGAAGAGGACTCAGAGGATGATGAGGATATGCA
GGACATGGACGAGATGAATGACTACAATGAGTCACCGGATGATGGAGAGGTCAATGAGGCTACCAGTTAGGGATCGGCAGGGACCACTTC
CTGACTAAGGAGCTGCAGCGATACATCGAAGGGCTCAAGAAGCGCCGGAGCAAGAGGCTGTACGTGAATTAAAAACGCCACCTTGGGCTC
GAGCAGCGACCCGAACCAGCCCCGTGCCAGCCCGGTCCCCAGACCCAAGCCTGACCCCATCCGAGTGGAATTTGAGTCCTAAAGAAATAA

>4275_4275_3_ANAPC15-TEX40_ANAPC15_chr11_71821134_ENST00000535234_TEX40_chr11_64072015_ENST00000328404_length(amino acids)=109AA_BP=
MSTLFPSLFPRVTETLWFNLDRPCVEETELQQQEQQHQAWLQSIAEKDNNLVPIGKPASEHYDDEEEEDDEDDEDSEEDSEDDEDMQDMD

--------------------------------------------------------------
>4275_4275_4_ANAPC15-TEX40_ANAPC15_chr11_71821134_ENST00000538919_TEX40_chr11_64072015_ENST00000328404_length(transcript)=946nt_BP=722nt
ACTTCTTGGACATGAGGGTGTTTACCGTCGTGCCTAATTACGCGGGTTGGGAATCTGAGATACAGGGAAGGGCAGCGGCTGGCCCTGGGT
CGGTCAGATAAATTAAGACAAAAGCAGGACCAGGCATCGATTATTTTCTCCTGCTCATCCCTTTCACGGAGGAATTCTAAGCCCCGACAC
ACTGTATGACCTAAAGCCAGTCTCTGCCTGTCGCTGGGCCTCAGTTCGCCTGTCCTAAGTTTAATTCAGATTATCTGGCACTCCTGGTCG
GCTCCCTCAGCCGCTCAAAGCTGATTGTACCCTTATAATATGAAGACACTGAGGCTCAGAGAGGTTAAGTGACTCAGCCAAGGTCAAACA
GCTAGTAAGTGGTGGAGCCAGGACTCAAAGCCAGTCTAGGAGCCATGTCCACTTTGTTCCCCTCACTCTTCCCTCGTGTGACTGAGACTC
TGTGGTTTAATCTGGATCGACCCTGTGTGGAAGAGACAGAGCTGCAGCAGCAGGAACAGCAGCATCAGGCCTGGCTCCAAAGCATCGCGG
AGAAAGACAACAACCTGGTTCCTATTGGCAAGCCAGCCTCAGAGCACTATGATGACGAGGAAGAAGAGGATGATGAAGATGATGAGGATA
GTGAAGAGGACTCAGAGGATGATGAGGATATGCAGGACATGGACGAGATGAATGACTACAATGAGTCACCGGATGATGGAGAGGTCAATG
AGGCTACCAGTTAGGGATCGGCAGGGACCACTTCCTGACTAAGGAGCTGCAGCGATACATCGAAGGGCTCAAGAAGCGCCGGAGCAAGAG
GCTGTACGTGAATTAAAAACGCCACCTTGGGCTCGAGCAGCGACCCGAACCAGCCCCGTGCCAGCCCGGTCCCCAGACCCAAGCCTGACC

>4275_4275_4_ANAPC15-TEX40_ANAPC15_chr11_71821134_ENST00000538919_TEX40_chr11_64072015_ENST00000328404_length(amino acids)=109AA_BP=
MSTLFPSLFPRVTETLWFNLDRPCVEETELQQQEQQHQAWLQSIAEKDNNLVPIGKPASEHYDDEEEEDDEDDEDSEEDSEDDEDMQDMD

--------------------------------------------------------------
>4275_4275_5_ANAPC15-TEX40_ANAPC15_chr11_71821134_ENST00000542531_TEX40_chr11_64072015_ENST00000328404_length(transcript)=696nt_BP=472nt
GCGACGGTGGGTTGGGCTTTCGGAGCCGAGATCGCTGGTCTGTCAGTACTTCTTGGACATGAGGATGAAGACACTGAGGCTCAGAGAGGT
TAAGTGACTCAGCCAAGGTCAAACAGCTAGTAAGTGGTGGAGCCAGGACTCAAAGCCAGGAGCCATGTCCACTTTGTTCCCCTCACTCTT
CCCTCGTGTGACTGAGACTCTGTGGTTTAATCTGGATCGACCCTGTGTGGAAGAGACAGAGCTGCAGCAGCAGGAACAGCAGCATCAGGC
CTGGCTCCAAAGCATCGCGGAGAAAGACAACAACCTGGTTCCTATTGGCAAGCCAGCCTCAGAGCACTATGATGACGAGGAAGAAGAGGA
TGATGAAGATGATGAGGATAGTGAAGAGGACTCAGAGGATGATGAGGATATGCAGGACATGGACGAGATGAATGACTACAATGAGTCACC
GGATGATGGAGAGGTCAATGAGGCTACCAGTTAGGGATCGGCAGGGACCACTTCCTGACTAAGGAGCTGCAGCGATACATCGAAGGGCTC
AAGAAGCGCCGGAGCAAGAGGCTGTACGTGAATTAAAAACGCCACCTTGGGCTCGAGCAGCGACCCGAACCAGCCCCGTGCCAGCCCGGT

>4275_4275_5_ANAPC15-TEX40_ANAPC15_chr11_71821134_ENST00000542531_TEX40_chr11_64072015_ENST00000328404_length(amino acids)=109AA_BP=
MSTLFPSLFPRVTETLWFNLDRPCVEETELQQQEQQHQAWLQSIAEKDNNLVPIGKPASEHYDDEEEEDDEDDEDSEEDSEDDEDMQDMD

--------------------------------------------------------------
>4275_4275_6_ANAPC15-TEX40_ANAPC15_chr11_71821134_ENST00000545680_TEX40_chr11_64072015_ENST00000328404_length(transcript)=742nt_BP=518nt
GACGAAGGACGCATGCGTTTGGTGAGTCCCGGATTCTGGTGGGTTCTTCCGCTCAGGCTGGGTGAAGCGCTTCCGGGTCGCCGCCGGCAG
CAGCCTCCCGGCGCGATGAAGACACTGAGGCTCAGAGAGGTTAAGTGACTCAGCCAAGGTCAAACAGCTAGTAAGTGGTGGAGCCAGGAC
TCAAAGCCAGTCTAGGAGCCATGTCCACTTTGTTCCCCTCACTCTTCCCTCGTGTGACTGAGACTCTGTGGTTTAATCTGGATCGACCCT
GTGTGGAAGAGACAGAGCTGCAGCAGCAGGAACAGCAGCATCAGGCCTGGCTCCAAAGCATCGCGGAGAAAGACAACAACCTGGTTCCTA
TTGGCAAGCCAGCCTCAGAGCACTATGATGACGAGGAAGAAGAGGATGATGAAGATGATGAGGATAGTGAAGAGGACTCAGAGGATGATG
AGGATATGCAGGACATGGACGAGATGAATGACTACAATGAGTCACCGGATGATGGAGAGGTCAATGAGGCTACCAGTTAGGGATCGGCAG
GGACCACTTCCTGACTAAGGAGCTGCAGCGATACATCGAAGGGCTCAAGAAGCGCCGGAGCAAGAGGCTGTACGTGAATTAAAAACGCCA
CCTTGGGCTCGAGCAGCGACCCGAACCAGCCCCGTGCCAGCCCGGTCCCCAGACCCAAGCCTGACCCCATCCGAGTGGAATTTGAGTCCT

>4275_4275_6_ANAPC15-TEX40_ANAPC15_chr11_71821134_ENST00000545680_TEX40_chr11_64072015_ENST00000328404_length(amino acids)=109AA_BP=
MSTLFPSLFPRVTETLWFNLDRPCVEETELQQQEQQHQAWLQSIAEKDNNLVPIGKPASEHYDDEEEEDDEDDEDSEEDSEDDEDMQDMD

--------------------------------------------------------------
>4275_4275_7_ANAPC15-TEX40_ANAPC15_chr11_71821134_ENST00000545944_TEX40_chr11_64072015_ENST00000539943_length(transcript)=593nt_BP=365nt
GCTTCCGGGTCGCCGCCGGCAGCAGCCTCCCGGCGCGTCTAGGAGCCATGTCCACTTTGTTCCCCTCACTCTTCCCTCGTGTGACTGAGA
CTCTGTGGTTTAATCTGGATCGACCCTGTGTGGAAGAGACAGAGCTGCAGCAGCAGGAACAGCAGCATCAGGCCTGGCTCCAAAGCATCG
CGGAGAAAGACAACAACCTGGTTCCTATTGGCAAGCCAGCCTCAGAGCACTATGATGACGAGGAAGAAGAGGATGATGAAGATGATGAGG
ATAGTGAAGAGGACTCAGAGGATGATGAGGATATGCAGGACATGGACGAGATGAATGACTACAATGAGTCACCGGATGATGGAGAGGTCA
ATGAGGCTACCAGTTAGGGATCGGCAGGGACCACTTCCTGACTAAGGAGCTGCAGCGATACATCGAAGGGCTCAAGAAGCGCCGGAGCAA
GAGGCTGTACGTGAATTAAAAACGCCACCTTGGGCTCGAGCAGCGACCCGAACCAGCCCCGTGCCAGCCCGGTCCCCAGACCCAAGCCTG

>4275_4275_7_ANAPC15-TEX40_ANAPC15_chr11_71821134_ENST00000545944_TEX40_chr11_64072015_ENST00000539943_length(amino acids)=109AA_BP=
MSTLFPSLFPRVTETLWFNLDRPCVEETELQQQEQQHQAWLQSIAEKDNNLVPIGKPASEHYDDEEEEDDEDDEDSEEDSEDDEDMQDMD

--------------------------------------------------------------

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Fusion Gene PPI Analysis for ANAPC15-TEX40


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ANAPC15-TEX40


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ANAPC15-TEX40


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource