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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:CLIC4-ARFGAP3 (FusionGDB2 ID:HG25932TG26286)

Fusion Gene Summary for CLIC4-ARFGAP3

check button Fusion gene summary
Fusion gene informationFusion gene name: CLIC4-ARFGAP3
Fusion gene ID: hg25932tg26286
HgeneTgene
Gene symbol

CLIC4

ARFGAP3

Gene ID

25932

26286

Gene namechloride intracellular channel 4ADP ribosylation factor GTPase activating protein 3
SynonymsCLIC4L|H1|MTCLIC|huH1|p64H1ARFGAP1
Cytomap('CLIC4')('ARFGAP3')

1p36.11

22q13.2

Type of geneprotein-codingprotein-coding
Descriptionchloride intracellular channel protein 4chloride intracellular channel 4 likeepididymis secretory sperm binding proteinintracellular chloride ion channel protein p64H1ADP-ribosylation factor GTPase-activating protein 3ADP-ribosylation factor GTPase activating protein 1ARF GAP 3
Modification date2020031320200313
UniProtAcc

Q9Y696

.
Ensembl transtripts involved in fusion geneENST00000497755, ENST00000374379, 
Fusion gene scores* DoF score14 X 6 X 9=7569 X 9 X 5=405
# samples 1715
** MAII scorelog2(17/756*10)=-2.15285148808337
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(15/405*10)=-1.43295940727611
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CLIC4 [Title/Abstract] AND ARFGAP3 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCLIC4(25072116)-ARFGAP3(43243638), # samples:3
Anticipated loss of major functional domain due to fusion event.CLIC4-ARFGAP3 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
CLIC4-ARFGAP3 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
CLIC4-ARFGAP3 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
CLIC4-ARFGAP3 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCLIC4

GO:0030336

negative regulation of cell migration

12163372


check buttonFusion gene breakpoints across CLIC4 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across ARFGAP3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LIHCTCGA-PD-A5DF-01ACLIC4chr1

25072116

-ARFGAP3chr22

43243638

-
ChimerDB4LIHCTCGA-PD-A5DF-01ACLIC4chr1

25072116

+ARFGAP3chr22

43243638

-


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Fusion Gene ORF analysis for CLIC4-ARFGAP3

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000497755ENST00000263245CLIC4chr1

25072116

+ARFGAP3chr22

43243638

-
3UTR-3CDSENST00000497755ENST00000429508CLIC4chr1

25072116

+ARFGAP3chr22

43243638

-
3UTR-3CDSENST00000497755ENST00000437119CLIC4chr1

25072116

+ARFGAP3chr22

43243638

-
In-frameENST00000374379ENST00000263245CLIC4chr1

25072116

+ARFGAP3chr22

43243638

-
In-frameENST00000374379ENST00000429508CLIC4chr1

25072116

+ARFGAP3chr22

43243638

-
In-frameENST00000374379ENST00000437119CLIC4chr1

25072116

+ARFGAP3chr22

43243638

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000374379CLIC4chr125072116+ENST00000263245ARFGAP3chr2243243638-28372691971750517
ENST00000374379CLIC4chr125072116+ENST00000429508ARFGAP3chr2243243638-17542691971534445
ENST00000374379CLIC4chr125072116+ENST00000437119ARFGAP3chr2243243638-17932691971618473

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000374379ENST00000263245CLIC4chr125072116+ARFGAP3chr2243243638-0.0011008610.9988991
ENST00000374379ENST00000429508CLIC4chr125072116+ARFGAP3chr2243243638-0.0027038940.99729615
ENST00000374379ENST00000437119CLIC4chr125072116+ARFGAP3chr2243243638-0.0021087360.99789125

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Fusion Genomic Features for CLIC4-ARFGAP3


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for CLIC4-ARFGAP3


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:25072116/chr22:43243638)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CLIC4

Q9Y696

.
FUNCTION: Can insert into membranes and form poorly selective ion channels that may also transport chloride ions. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions. Promotes cell-surface expression of HRH3. Has alternate cellular functions like a potential role in angiogenesis or in maintaining apical-basolateral membrane polarity during mitosis and cytokinesis. Could also promote endothelial cell proliferation and regulate endothelial morphogenesis (tubulogenesis). {ECO:0000269|PubMed:12163372, ECO:0000269|PubMed:14569596, ECO:0000269|PubMed:16176272, ECO:0000269|PubMed:16239224, ECO:0000269|PubMed:18302930, ECO:0000269|PubMed:19247789}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneARFGAP3chr1:25072116chr22:43243638ENST00000263245016243_26323517.0Coiled coilOntology_term=ECO:0000255
TgeneARFGAP3chr1:25072116chr22:43243638ENST00000437119015243_26323473.0Coiled coilOntology_term=ECO:0000255
TgeneARFGAP3chr1:25072116chr22:43243638ENST00000263245016348_37723517.0Compositional biasNote=Ser-rich
TgeneARFGAP3chr1:25072116chr22:43243638ENST00000437119015348_37723473.0Compositional biasNote=Ser-rich
TgeneARFGAP3chr1:25072116chr22:43243638ENST0000026324501625_4823517.0Zinc fingerC4-type
TgeneARFGAP3chr1:25072116chr22:43243638ENST0000043711901525_4823473.0Zinc fingerC4-type

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCLIC4chr1:25072116chr22:43243638ENST00000374379+16104_24424254.0DomainNote=GST C-terminal
HgeneCLIC4chr1:25072116chr22:43243638ENST00000374379+162_10124254.0RegionRequired for insertion into the membrane
HgeneCLIC4chr1:25072116chr22:43243638ENST00000374379+1637_5724254.0TransmembraneHelical%3B Note%3DAfter insertion into the membrane
TgeneARFGAP3chr1:25072116chr22:43243638ENST0000026324501610_12623517.0DomainArf-GAP
TgeneARFGAP3chr1:25072116chr22:43243638ENST0000043711901510_12623473.0DomainArf-GAP


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Fusion Gene Sequence for CLIC4-ARFGAP3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>17117_17117_1_CLIC4-ARFGAP3_CLIC4_chr1_25072116_ENST00000374379_ARFGAP3_chr22_43243638_ENST00000263245_length(transcript)=2837nt_BP=269nt
AAGCGGCTCGGGCTGCGGCTGGCTCAGAGTGGCGCGGGGGGCGTGGGGCGGTGCTGAGGAGCTGAAGCCGTGGCCAGCTCGACGCCGGAC
AGTCCAGCGAGCAGCACGGCGGGAACCGGCAGCCGGAGCAGTCCCGGAGCAGAAGCAGCAGCAGCAGCAGCAGCCCTCGCCGTTCGCGGA
GCGCAGCCGAGCCGGCCATGGCGTTGTCGATGCCGCTGAATGGGCTGAAGGAGGAGGACAAAGAGCCCCTCATCGAGCTCTTCGTCAAGG
TGTGTTTTGATTGTGGTGCCAAAAATCCCAGCTGGGCAAGCATAACCTATGGAGTGTTCCTTTGCATTGATTGCTCAGGGTCCCACCGGT
CACTTGGTGTTCACTTGAGTTTTATTCGATCTACAGAGTTGGATTCCAACTGGTCATGGTTTCAGTTGCGATGCATGCAAGTCGGAGGAA
ACGCTAGTGCATCTTCCTTTTTTCATCAACATGGGTGTTCCACCAATGACACCAATGCCAAGTACAACAGTCGTGCTGCTCAGCTCTATA
GGGAGAAAATCAAATCGCTCGCCTCTCAAGCAACACGGAAGCATGGCACTGATCTGTGGCTTGATAGTTGTGTGGTTCCACCTTTGTCCC
CTCCACCAAAGGAGGAAGATTTTTTTGCCTCTCACGTTTCTCCTGAGGTGAGTGACACAGCGTGGGCATCAGCAATAGCAGAACCATCTT
CTTTAACATCAAGGCCTGTGGAAACCACTTTGGAAAATAATGAAGGTGGACAAGAGCAAGGACCAAGTGTGGAAGGTCTTAATGTACCAA
CAAAGGCTACTTTAGAGGTATCCTCTATCATAAAAAAGAAACCAAATCAAGCTAAAAAAGGCCTTGGGGCCAAAAAAGGAAGTTTGGGAG
CTCAGAAACTGGCAAACACATGCTTTAATGAAATTGAAAAACAAGCTCAAGCTGCGGATAAAATGAAGGAGCAGGAAGACCTGGCCAAGG
TGGTATCTAAAGAAGAATCAATTGTTTCATCATTACGATTAGCCTATAAGGATCTTGAAATTCAAATGAAGAAAGACGAAAAGATGAACA
TTAGTGGCAAAAAAAATGTTGACTCAGACAGACTCGGCATGGGATTTGGAAATTGCAGAAGTGTTATTTCACATTCAGTGACTTCAGATA
TGCAGACCATAGAGCAGGAATCACCCATTATGGCAAAACCAAGAAAAAAGTATAATGATGACAGTGACGATTCATATTTTACTTCCAGCT
CAAGTTACTTTGACGAGCCAGTGGAGTTAAGGAGCAGTTCTTTCTCTAGCTGGGATGACAGTTCAGATTCCTATTGGAAAAAAGAGACCA
GCAAAGATACTGAAACAGTTCTGAAAACCACAGGCTATTCAGACAGACCTACTGCTCGCCGCAAGCCAGATTATGAGCCAGTTGAAAATA
CAGATGAGGCCCAGAAGAAGTTTGGCAATGTCAAGGCCATTTCATCAGATATGTATTTTGGAAGACAATCCCAGGCTGATTATGAGACCA
GGGCCCGCCTAGAGAGGCTGTCGGCAAGTTCCTCCATAAGCTCGGCTGATCTGTTCGAGGAGCCGAGGAAGCAGCCAGCAGGGAACTACA
GCCTGTCCAGTGTGCTGCCCAACGCCCCCGACATGGCGCAGTTCAAGCAGGGAGTGAGATCGGTTGCTGGAAAACTCTCCGTCTTTGCTA
ATGGAGTCGTGACTTCAATTCAGGATCGCTACGGTTCTTAATACTGAAGTCATGATGTGTATTTCCTGGAGAAATTCCTCTTTAAATGAA
CAAGTAACCACATCTCAGGCGGCAGTGAAGTCCAGATAGTTTTGCAGATTGTTTTGCTACTTTTTCATATGGTATATGTTTCTGATTTTT
AATATTTCTTTTGAGAAATTCTGAGTTCTGATGTAGGAGCTTTCCTGTGATTTCTGTTTCACGTTCCTTCCTGTCACACCCTCCTTTGGC
GTCTCTGTGTATATCCTTGCTTTATTTTCTTGGAACCTTTGATTTCAACACTGAGGGCCTGGAGACCTCGGCTCCTCCTGCTCCTGAACC
AGGAGGCTTCATGTGGGGGAGGAGGAGAGGTCTCCATGTGACACATGGGCTCAGGGCTGCCAGAATCAGCGGATGCTGGATGGGCCTGCA
GAAACAACACTCACCACACACACTTCCTTCAAAAGACCAAAAGTGACTGGTGTCTCGTGTGACAGATTGCTTCATTTATGTTTCTACATA
GTAAGGTGACTGCCAAATAATATTTGAAGTCATCTGTCTCTTTGTAAATTATTTTATATGACCTATAAATTTAAAAATGTTTTTCAGTGA
GTGCTTTTAACAAACTTAAGCTTCTGCCCTGCCAAGGGAATTAATGTTATCTTGTGAAAGGTGTTGCTGTTTGAATTGATGAGAAATGGA
AGATGAGAACTCCCTAAGAGTTCTCATAATAAATCATCTCATCACAAATCAATACGGTATACAGAGTTAAAGTGGAATGAGGTAAGAAGA
TACAGCTACAGAAAATAGTTGCGTGTATGGGAGAACAGTCATTGTAATTGGGTAGTTTTGTTAATAAATATTTTTAAATCTTGCTTTTCA
GAAATTACCGAATGTGTATAAACAAATAAAGAAAAATAATTTAGCTGTGTTTTAGACAGCATTAGAATATATTGTTCAGCACAGTAAAAT
ATATTTGAAATTTGATAAGCCAAAAATGTGGTTTTGAATGAATATTTTGTGAATCTTTCTTAAAAGCTCAAATTTGTAGACTTCTAAATA

>17117_17117_1_CLIC4-ARFGAP3_CLIC4_chr1_25072116_ENST00000374379_ARFGAP3_chr22_43243638_ENST00000263245_length(amino acids)=517AA_BP=24
MALSMPLNGLKEEDKEPLIELFVKVCFDCGAKNPSWASITYGVFLCIDCSGSHRSLGVHLSFIRSTELDSNWSWFQLRCMQVGGNASASS
FFHQHGCSTNDTNAKYNSRAAQLYREKIKSLASQATRKHGTDLWLDSCVVPPLSPPPKEEDFFASHVSPEVSDTAWASAIAEPSSLTSRP
VETTLENNEGGQEQGPSVEGLNVPTKATLEVSSIIKKKPNQAKKGLGAKKGSLGAQKLANTCFNEIEKQAQAADKMKEQEDLAKVVSKEE
SIVSSLRLAYKDLEIQMKKDEKMNISGKKNVDSDRLGMGFGNCRSVISHSVTSDMQTIEQESPIMAKPRKKYNDDSDDSYFTSSSSYFDE
PVELRSSSFSSWDDSSDSYWKKETSKDTETVLKTTGYSDRPTARRKPDYEPVENTDEAQKKFGNVKAISSDMYFGRQSQADYETRARLER

--------------------------------------------------------------
>17117_17117_2_CLIC4-ARFGAP3_CLIC4_chr1_25072116_ENST00000374379_ARFGAP3_chr22_43243638_ENST00000429508_length(transcript)=1754nt_BP=269nt
AAGCGGCTCGGGCTGCGGCTGGCTCAGAGTGGCGCGGGGGGCGTGGGGCGGTGCTGAGGAGCTGAAGCCGTGGCCAGCTCGACGCCGGAC
AGTCCAGCGAGCAGCACGGCGGGAACCGGCAGCCGGAGCAGTCCCGGAGCAGAAGCAGCAGCAGCAGCAGCAGCCCTCGCCGTTCGCGGA
GCGCAGCCGAGCCGGCCATGGCGTTGTCGATGCCGCTGAATGGGCTGAAGGAGGAGGACAAAGAGCCCCTCATCGAGCTCTTCGTCAAGG
TGTGTTTTGATTGTGGTGCCAAAAATCCCAGCTGGGCAAGCATAACCTATGGAGTGTTCCTTTGCATTGATTGCTCAGGGTCCCACCGGT
CACTTGGTGTTCACTTGAGTTTTATTCGATCTACAGAGTTGGATTCCAACTGGTCATGGTTTCAGTTGCGATGCATGCAAGTCGGAGGAA
ACGCTAGTGCAGTGAGTGACACAGCGTGGGCATCAGCAATAGCAGAACCATCTTCTTTAACATCAAGGCCTGTGGAAACCACTTTGGAAA
ATAATGAAGGTGGACAAGAGCAAGGACCAAGTGTGGAAGGTCTTAATGTACCAACAAAGGCTACTTTAGAGGTATCCTCTATCATAAAAA
AGAAACCAAATCAAGCTAAAAAAGGCCTTGGGGCCAAAAAAGGAAGTTTGGGAGCTCAGAAACTGGCAAACACATGCTTTAATGAAATTG
AAAAACAAGCTCAAGCTGCGGATAAAATGAAGGAGCAGGAAGACCTGGCCAAGGTGGTATCTAAAGAAGAATCAATTGTTTCATCATTAC
GATTAGCCTATAAGGATCTTGAAATTCAAATGAAGAAAGACGAAAAGATGAACATTAGTGGCAAAAAAAATGTTGACTCAGACAGACTCG
GCATGGGATTTGGAAATTGCAGAAGTGTTATTTCACATTCAGTGACTTCAGATATGCAGACCATAGAGCAGGAATCACCCATTATGGCAA
AACCAAGAAAAAAGTATAATGATGACAGTGACGATTCATATTTTACTTCCAGCTCAAGTTACTTTGACGAGCCAGTGGAGTTAAGGAGCA
GTTCTTTCTCTAGCTGGGATGACAGTTCAGATTCCTATTGGAAAAAAGAGACCAGCAAAGATACTGAAACAGTTCTGAAAACCACAGGCT
ATTCAGACAGACCTACTGCTCGCCGCAAGCCAGATTATGAGCCAGTTGAAAATACAGATGAGGCCCAGAAGAAGTTTGGCAATGTCAAGG
CCATTTCATCAGATATGTATTTTGGAAGACAATCCCAGGCTGATTATGAGACCAGGGCCCGCCTAGAGAGGCTGTCGGCAAGTTCCTCCA
TAAGCTCGGCTGATCTGTTCGAGGAGCCGAGGAAGCAGCCAGCAGGGAACTACAGCCTGTCCAGTGTGCTGCCCAACGCCCCCGACATGG
CGCAGTTCAAGCAGGGAGTGAGATCGGTTGCTGGAAAACTCTCCGTCTTTGCTAATGGAGTCGTGACTTCAATTCAGGATCGCTACGGTT
CTTAATACTGAAGTCATGATGTGTATTTCCTGGAGAAATTCCTCTTTAAATGAACAAGTAACCACATCTCAGGCGGCAGTGAAGTCCAGA
TAGTTTTGCAGATTGTTTTGCTACTTTTTCATATGGTATATGTTTCTGATTTTTAATATTTCTTTTGAGAAATTCTGAGTTCTGATGTAG

>17117_17117_2_CLIC4-ARFGAP3_CLIC4_chr1_25072116_ENST00000374379_ARFGAP3_chr22_43243638_ENST00000429508_length(amino acids)=445AA_BP=24
MALSMPLNGLKEEDKEPLIELFVKVCFDCGAKNPSWASITYGVFLCIDCSGSHRSLGVHLSFIRSTELDSNWSWFQLRCMQVGGNASAVS
DTAWASAIAEPSSLTSRPVETTLENNEGGQEQGPSVEGLNVPTKATLEVSSIIKKKPNQAKKGLGAKKGSLGAQKLANTCFNEIEKQAQA
ADKMKEQEDLAKVVSKEESIVSSLRLAYKDLEIQMKKDEKMNISGKKNVDSDRLGMGFGNCRSVISHSVTSDMQTIEQESPIMAKPRKKY
NDDSDDSYFTSSSSYFDEPVELRSSSFSSWDDSSDSYWKKETSKDTETVLKTTGYSDRPTARRKPDYEPVENTDEAQKKFGNVKAISSDM

--------------------------------------------------------------
>17117_17117_3_CLIC4-ARFGAP3_CLIC4_chr1_25072116_ENST00000374379_ARFGAP3_chr22_43243638_ENST00000437119_length(transcript)=1793nt_BP=269nt
AAGCGGCTCGGGCTGCGGCTGGCTCAGAGTGGCGCGGGGGGCGTGGGGCGGTGCTGAGGAGCTGAAGCCGTGGCCAGCTCGACGCCGGAC
AGTCCAGCGAGCAGCACGGCGGGAACCGGCAGCCGGAGCAGTCCCGGAGCAGAAGCAGCAGCAGCAGCAGCAGCCCTCGCCGTTCGCGGA
GCGCAGCCGAGCCGGCCATGGCGTTGTCGATGCCGCTGAATGGGCTGAAGGAGGAGGACAAAGAGCCCCTCATCGAGCTCTTCGTCAAGG
TGTGTTTTGATTGTGGTGCCAAAAATCCCAGCTGGGCAAGCATAACCTATGGAGTGTTCCTTTGCATTGATTGCTCAGGGTCCCACCGGT
CACTTGGTGTTCACTTGAGTTTTATTCGATCTACAGAGTTGGATTCCAACTGGTCATGGTTTCAGTTGCGATGCATGCAAGTCGGAGGAA
ACGCTAGTGCACTGTGGCTTGATAGTTGTGTGGTTCCACCTTTGTCCCCTCCACCAAAGGAGGAAGATTTTTTTGCCTCTCACGTTTCTC
CTGAGGTGAGTGACACAGCGTGGGCATCAGCAATAGCAGAACCATCTTCTTTAACATCAAGGCCTGTGGAAACCACTTTGGAAAATAATG
AAGGTGGACAAGAGCAAGGACCAAGTGTGGAAGGTCTTAATGTACCAACAAAGGCTACTTTAGAGGTATCCTCTATCATAAAAAAGAAAC
CAAATCAAGCTAAAAAAGGCCTTGGGGCCAAAAAAGGAAGTTTGGGAGCTCAGAAACTGGCAAACACATGCTTTAATGAAATTGAAAAAC
AAGCTCAAGCTGCGGATAAAATGAAGGAGCAGGAAGACCTGGCCAAGGTGGTATCTAAAGAAGAATCAATTGTTTCATCATTACGATTAG
CCTATAAGGATCTTGAAATTCAAATGAAGAAAGACGAAAAGATGAACATTAGTGGCAAAAAAAATGTTGACTCAGACAGACTCGGCATGG
GATTTGGAAATTGCAGAAGTGTTATTTCACATTCAGTGACTTCAGATATGCAGACCATAGAGCAGGAATCACCCATTATGGCAAAACCAA
GAAAAAAGTATAATGATGACAGTGACGATTCATATTTTACTTCCAGCTCAAGTTACTTTGACGAGCCAGTGGAGTTAAGGAGCAGTTCTT
TCTCTAGCTGGGATGACAGTTCAGATTCCTATTGGAAAAAAGAGACCAGCAAAGATACTGAAACAGTTCTGAAAACCACAGGCTATTCAG
ACAGACCTACTGCTCGCCGCAAGCCAGATTATGAGCCAGTTGAAAATACAGATGAGGCCCAGAAGAAGTTTGGCAATGTCAAGGCCATTT
CATCAGATATGTATTTTGGAAGACAATCCCAGGCTGATTATGAGACCAGGGCCCGCCTAGAGAGGCTGTCGGCAAGTTCCTCCATAAGCT
CGGCTGATCTGTTCGAGGAGCCGAGGAAGCAGCCAGCAGGGAACTACAGCCTGTCCAGTGTGCTGCCCAACGCCCCCGACATGGCGCAGT
TCAAGCAGGGAGTGAGATCGGTTGCTGGAAAACTCTCCGTCTTTGCTAATGGAGTCGTGACTTCAATTCAGGATCGCTACGGTTCTTAAT
ACTGAAGTCATGATGTGTATTTCCTGGAGAAATTCCTCTTTAAATGAACAAGTAACCACATCTCAGGCGGCAGTGAAGTCCAGATAGTTT

>17117_17117_3_CLIC4-ARFGAP3_CLIC4_chr1_25072116_ENST00000374379_ARFGAP3_chr22_43243638_ENST00000437119_length(amino acids)=473AA_BP=24
MALSMPLNGLKEEDKEPLIELFVKVCFDCGAKNPSWASITYGVFLCIDCSGSHRSLGVHLSFIRSTELDSNWSWFQLRCMQVGGNASALW
LDSCVVPPLSPPPKEEDFFASHVSPEVSDTAWASAIAEPSSLTSRPVETTLENNEGGQEQGPSVEGLNVPTKATLEVSSIIKKKPNQAKK
GLGAKKGSLGAQKLANTCFNEIEKQAQAADKMKEQEDLAKVVSKEESIVSSLRLAYKDLEIQMKKDEKMNISGKKNVDSDRLGMGFGNCR
SVISHSVTSDMQTIEQESPIMAKPRKKYNDDSDDSYFTSSSSYFDEPVELRSSSFSSWDDSSDSYWKKETSKDTETVLKTTGYSDRPTAR
RKPDYEPVENTDEAQKKFGNVKAISSDMYFGRQSQADYETRARLERLSASSSISSADLFEEPRKQPAGNYSLSSVLPNAPDMAQFKQGVR

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Fusion Gene PPI Analysis for CLIC4-ARFGAP3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for CLIC4-ARFGAP3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for CLIC4-ARFGAP3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneCLIC4C0029408Degenerative polyarthritis1CTD_human
HgeneCLIC4C0033578Prostatic Neoplasms1CTD_human
HgeneCLIC4C0043094Weight Gain1CTD_human
HgeneCLIC4C0086743Osteoarthrosis Deformans1CTD_human
HgeneCLIC4C0376358Malignant neoplasm of prostate1CTD_human