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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:C2CD3-TENM4 (FusionGDB2 ID:HG26005TG26011)

Fusion Gene Summary for C2CD3-TENM4

check button Fusion gene summary
Fusion gene informationFusion gene name: C2CD3-TENM4
Fusion gene ID: hg26005tg26011
HgeneTgene
Gene symbol

C2CD3

TENM4

Gene ID

26005

26011

Gene nameC2 domain containing 3 centriole elongation regulatorteneurin transmembrane protein 4
SynonymsOFD14Doc4|ETM5|ODZ4|TEN4|TNM4|Ten-M4|ten-4
Cytomap('C2CD3','C2CD3')('ODZ4','TENM4')

11q13.4

11q14.1

Type of geneprotein-codingprotein-coding
DescriptionC2 domain-containing protein 3C2 calcium dependent domain containing 3teneurin-4odz, odd Oz/ten-m homolog 4protein Odd Oz/ten-m homolog 4tenascin-M4
Modification date2020032920200313
UniProtAcc

Q4AC94

.
Ensembl transtripts involved in fusion geneENST00000334126, ENST00000542452, 
ENST00000313663, ENST00000539061, 
Fusion gene scores* DoF score15 X 15 X 9=202517 X 17 X 9=2601
# samples 1818
** MAII scorelog2(18/2025*10)=-3.49185309632968
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(18/2601*10)=-3.85299758761332
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: C2CD3 [Title/Abstract] AND TENM4 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointC2CD3(73739332)-ODZ4(78383374), # samples:1
C2CD3(73739332)-TENM4(78383374), # samples:1
Anticipated loss of major functional domain due to fusion event.C2CD3-TENM4 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
C2CD3-TENM4 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
C2CD3-TENM4 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
C2CD3-TENM4 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneC2CD3

GO:0061511

centriole elongation

24997988

HgeneC2CD3

GO:0071539

protein localization to centrosome

24997988


check buttonFusion gene breakpoints across C2CD3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across TENM4 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-A7-A4SB-01AC2CD3chr11

73739332

-ODZ4chr11

78383374

-
ChimerDB4BRCATCGA-A7-A4SB-01AC2CD3chr11

73739332

-TENM4chr11

78383374

-


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Fusion Gene ORF analysis for C2CD3-TENM4

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000334126ENST00000533038C2CD3chr11

73739332

-TENM4chr11

78383374

-
5UTR-3CDSENST00000542452ENST00000278550C2CD3chr11

73739332

-TENM4chr11

78383374

-
5UTR-intronENST00000542452ENST00000533038C2CD3chr11

73739332

-TENM4chr11

78383374

-
In-frameENST00000334126ENST00000278550C2CD3chr11

73739332

-TENM4chr11

78383374

-
intron-3CDSENST00000313663ENST00000278550C2CD3chr11

73739332

-TENM4chr11

78383374

-
intron-3CDSENST00000539061ENST00000278550C2CD3chr11

73739332

-TENM4chr11

78383374

-
intron-intronENST00000313663ENST00000533038C2CD3chr11

73739332

-TENM4chr11

78383374

-
intron-intronENST00000539061ENST00000533038C2CD3chr11

73739332

-TENM4chr11

78383374

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000334126C2CD3chr1173739332-ENST00000278550TENM4chr1178383374-15189714822799613244

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000334126ENST00000278550C2CD3chr1173739332-TENM4chr1178383374-0.0013830830.99861693

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Fusion Genomic Features for C2CD3-TENM4


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for C2CD3-TENM4


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr11:73739332/chr11:78383374)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
C2CD3

Q4AC94

.
FUNCTION: Component of the centrioles that acts as a positive regulator of centriole elongation (PubMed:24997988). Promotes assembly of centriolar distal appendage, a structure at the distal end of the mother centriole that acts as an anchor of the cilium, and is required for recruitment of centriolar distal appendages proteins CEP83, SCLT1, CEP89, FBF1 and CEP164. Not required for centriolar satellite integrity or RAB8 activation. Required for primary cilium formation (PubMed:23769972). Required for sonic hedgehog/SHH signaling and for proteolytic processing of GLI3. {ECO:0000269|PubMed:23769972, ECO:0000269|PubMed:24997988}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneC2CD3chr11:73739332chr11:78383374ENST00000334126-32331171_133923072354.0DomainC2 4
HgeneC2CD3chr11:73739332chr11:78383374ENST00000334126-32331403_153323072354.0DomainC2 5
HgeneC2CD3chr11:73739332chr11:78383374ENST00000334126-32331617_174523072354.0DomainC2 6
HgeneC2CD3chr11:73739332chr11:78383374ENST00000334126-3233521_67823072354.0DomainC2 1
HgeneC2CD3chr11:73739332chr11:78383374ENST00000334126-3233787_91923072354.0DomainC2 2
HgeneC2CD3chr11:73739332chr11:78383374ENST00000334126-3233985_114723072354.0DomainC2 3
TgeneTENM4chr11:73739332chr11:78383374ENST0000027855029341887_190618322770.0RepeatNote=YD 5
TgeneTENM4chr11:73739332chr11:78383374ENST0000027855029341928_194618322770.0RepeatNote=YD 6
TgeneTENM4chr11:73739332chr11:78383374ENST0000027855029341947_196718322770.0RepeatNote=YD 7
TgeneTENM4chr11:73739332chr11:78383374ENST0000027855029341974_199118322770.0RepeatNote=YD 8
TgeneTENM4chr11:73739332chr11:78383374ENST0000027855029341992_201318322770.0RepeatNote=YD 9
TgeneTENM4chr11:73739332chr11:78383374ENST0000027855029342014_203118322770.0RepeatNote=YD 10
TgeneTENM4chr11:73739332chr11:78383374ENST0000027855029342034_205418322770.0RepeatNote=YD 11
TgeneTENM4chr11:73739332chr11:78383374ENST0000027855029342057_207718322770.0RepeatNote=YD 12
TgeneTENM4chr11:73739332chr11:78383374ENST0000027855029342085_210418322770.0RepeatNote=YD 13
TgeneTENM4chr11:73739332chr11:78383374ENST0000027855029342110_212718322770.0RepeatNote=YD 14
TgeneTENM4chr11:73739332chr11:78383374ENST0000027855029342128_215418322770.0RepeatNote=YD 15
TgeneTENM4chr11:73739332chr11:78383374ENST0000027855029342156_216918322770.0RepeatNote=YD 16
TgeneTENM4chr11:73739332chr11:78383374ENST0000027855029342170_219318322770.0RepeatNote=YD 17
TgeneTENM4chr11:73739332chr11:78383374ENST0000027855029342196_221618322770.0RepeatNote=YD 18
TgeneTENM4chr11:73739332chr11:78383374ENST0000027855029342217_223718322770.0RepeatNote=YD 19
TgeneTENM4chr11:73739332chr11:78383374ENST0000027855029342239_225918322770.0RepeatNote=YD 20
TgeneTENM4chr11:73739332chr11:78383374ENST0000027855029342271_229118322770.0RepeatNote=YD 21
TgeneTENM4chr11:73739332chr11:78383374ENST0000027855029342293_231318322770.0RepeatNote=YD 22
TgeneTENM4chr11:73739332chr11:78383374ENST0000027855029342339_238018322770.0RepeatNote=YD 23

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneC2CD3chr11:73739332chr11:78383374ENST00000313663-1311171_133901964.0DomainC2 4
HgeneC2CD3chr11:73739332chr11:78383374ENST00000313663-1311403_153301964.0DomainC2 5
HgeneC2CD3chr11:73739332chr11:78383374ENST00000313663-1311617_174501964.0DomainC2 6
HgeneC2CD3chr11:73739332chr11:78383374ENST00000313663-131521_67801964.0DomainC2 1
HgeneC2CD3chr11:73739332chr11:78383374ENST00000313663-131787_91901964.0DomainC2 2
HgeneC2CD3chr11:73739332chr11:78383374ENST00000313663-131985_114701964.0DomainC2 3
TgeneTENM4chr11:73739332chr11:78383374ENST000002785502934179_18218322770.0Compositional biasNote=Poly-Pro
TgeneTENM4chr11:73739332chr11:78383374ENST0000027855029341_34118322770.0DomainTeneurin N-terminal
TgeneTENM4chr11:73739332chr11:78383374ENST000002785502934562_59318322770.0DomainEGF-like 1
TgeneTENM4chr11:73739332chr11:78383374ENST000002785502934594_62418322770.0DomainEGF-like 2
TgeneTENM4chr11:73739332chr11:78383374ENST000002785502934626_65818322770.0DomainEGF-like 3
TgeneTENM4chr11:73739332chr11:78383374ENST000002785502934659_69018322770.0DomainEGF-like 4
TgeneTENM4chr11:73739332chr11:78383374ENST000002785502934692_72518322770.0DomainEGF-like 5
TgeneTENM4chr11:73739332chr11:78383374ENST000002785502934726_75718322770.0DomainEGF-like 6
TgeneTENM4chr11:73739332chr11:78383374ENST000002785502934758_78718322770.0DomainEGF-like 7
TgeneTENM4chr11:73739332chr11:78383374ENST000002785502934788_83118322770.0DomainEGF-like 8
TgeneTENM4chr11:73739332chr11:78383374ENST0000027855029341216_125918322770.0RepeatNote=NHL 1
TgeneTENM4chr11:73739332chr11:78383374ENST0000027855029341264_130818322770.0RepeatNote=NHL 2
TgeneTENM4chr11:73739332chr11:78383374ENST0000027855029341334_137818322770.0RepeatNote=NHL 3
TgeneTENM4chr11:73739332chr11:78383374ENST0000027855029341393_144418322770.0RepeatNote=NHL 4
TgeneTENM4chr11:73739332chr11:78383374ENST0000027855029341523_156618322770.0RepeatNote=NHL 5
TgeneTENM4chr11:73739332chr11:78383374ENST0000027855029341576_159518322770.0RepeatNote=YD 1
TgeneTENM4chr11:73739332chr11:78383374ENST0000027855029341612_163218322770.0RepeatNote=YD 2
TgeneTENM4chr11:73739332chr11:78383374ENST0000027855029341675_169418322770.0RepeatNote=YD 3
TgeneTENM4chr11:73739332chr11:78383374ENST0000027855029341695_171718322770.0RepeatNote=YD 4
TgeneTENM4chr11:73739332chr11:78383374ENST0000027855029341_34518322770.0Topological domainCytoplasmic
TgeneTENM4chr11:73739332chr11:78383374ENST000002785502934367_276918322770.0Topological domainExtracellular
TgeneTENM4chr11:73739332chr11:78383374ENST000002785502934346_36618322770.0TransmembraneHelical


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Fusion Gene Sequence for C2CD3-TENM4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>11611_11611_1_C2CD3-TENM4_C2CD3_chr11_73739332_ENST00000334126_TENM4_chr11_78383374_ENST00000278550_length(transcript)=15189nt_BP=7148nt
AAAGCGTCCTGGGTATTGTAGTGTATTGGAGGGAAGGCGTCTTGGCGCCTTCTCTTCGCACCGTTTTCCGGAGACTGTTAGAGGAAGAGT
CGCTTTTTCCTGCCTCCCAGGCTGCCCAGCGGCGCCGGTTGCCGGGGAACGCAGGCGCCGTGGGGAGGGATGGCGGGAGGATACTGCTTA
GGTGCTGGAGACGGAGTTGAGCTGGTGAAGAAGAGCTCGGGCTCATCATGAAACAACGAAAAGGCCAAGGGTCTGGGGGCAGCCGTGGGC
GCAAAAAAAGAGGTTTAAGTGACATTTCTCCATCTACAAGCCTGCCACCTCTGGTTGAAGGCCAGCTACGCTGTTTTCTAAAACTTACTG
TTAATAGAGTCATATGGAAGATTGCAAAGCCTCCCACTTGTGTACTTGTCCGAGTGAGATGGTGGGGAGAAACATCAGATGGAACCCTCT
TTTGTCCCAGGGATGCATTGCAGACTGAACCAAAAGCTGTGAGAACAACTACACGTTACGCTATTCGTTGTGGTCCAAAACAGTTTACCT
CTTATCTAACAGATATGGCTGTGCTGGTGCTGGAAGTAATCACCAAACTTGATGGTCTTCCAATTGGTAGAGTTCAGATCAATGGACTAG
CTCAACTTTCTCCAACCCATCAAATCAATGGATTTTTTACCATTGTTTCATCAACGTCTAAGAAACTTGGAGAACTCCAGGTCTCACTTG
CCCTGGAACCTCTGTCAGAAACTTACGACAGCTACCATCCACTTCCTACCACTGACATGACAGAAAATGTGCTTTTATCTAAGCAGGGAT
TCAGAGAGAATACTGAACCCAGCAGTACCCAGTTTCAGGTTCCATCAAGGCCTCGCGACATACATACCATCAAAATTGATGGAAAAGAGT
TAGCAGCCAACAGCAGTAGATCAACCACTCCGAGGGGAAAAGACCATGTATGCTTTGCAGAGAACCCTGATACAATAAAGGATTCTTCCT
TTGGACTACAGCACAGTCTTAATTCAGGACAGAGTTTAGAGTCTGTAACTCTGAAAGGCAGAGCTCCACGGAAGCAGATGTCCCTTCTGA
ACAGTTCTGAATTCCAGCCTCAAATTAGAACAGTTGCCAAGAGTCACAGTGACTCATGCATTCTTTCTTCAAACAACCTCCCTACCAAGG
ATCTTCTTTCAGCTCTGTTAGAACAAGGCAATAAACTGCGTAATGCCATGGTGATTTCTGCAATGAAATCAAGCCCAGAGACCAGCATGT
TGTTGGACCAAGTTCATCCTCCTATTAATGAAGATTCTCTTAGAGCATCAACACAGATCAGAGCCTTTTCTAGGAATCGGTTTAAAGACC
ACATTGAAGATCACCTCCTCCCTTCAACTGAGAATACATTTTGGAGACATGACACAAAAGCTGATACCAGAGCTATACAGCTGCTATTAG
GCAGTGCTGAATTATCCCAAGGCAATTTCTGGGATGGGCTAGGCTCTCCTCCAGATTCCCCATCTCCTGGGAGTGATGTGTATTGCATCA
GTGAGCTGAATGACCCTCAGTATGACCAGAGTCTTCTGGAGAATTTATTTTATACAGCACCTAAATCTGATACCAGCATCAGTGATTTCC
TCAGTGAAGAGGATGATATCGTCCCTTCTAAAAAAATAAGCCAGTCAACAGCTCTTGCCAGATCATCTAAGGTTCTGGAGTCAAGTGATC
ATAAGCTGAAGAAGAGGTCAGCAGGCAAGAGAAATAGAAATTTGGTTGAACAACAGATGCTCTCAGAAACTCCAGAAGATGCCCAAACGA
TGACACTAAGTGTGGATAGACTGGCCCTTTTGGGTAGAACACATTCAGTCAGAATCATCATCGAAACCATGGGAGTTCCTCCAGATAGTC
CTCAGATGACCCCTGGCAAAAAAAGCTATGCTGGTCCACCACCTAAGGTGACTACAGCAAAAAAGCGCACTTTCTTTGTAGAATATCACT
TTCCTGTGGGCTTTTCGGAAAGCGGATTGGGAAAGACAGCTTTGATCACTGAGGTTGTTCGACTCGCCTCCAGTAAAATTACAGATGGAA
AGGTGAAGTTCCAGCAGCGATTTGTGTTTCCAGTACAGTTTGGTGGCCCAATGATAGAGCACTGGTGGAATTCCAACCTCACTTTCCAAA
TTTATGTAAAGAAAACTCCACAGAAAAAGCCAGAAGTCATTGGATCTGTGTCACTTTCTTTGCGAGCTGTCATTCAATCAGAGCTGCTTT
CTTTCAGTGATCAGCTTCCAGTGCAACAAGAAAATGGTCAGTCTCCATTTGGCCCCCTCAAGGTAACCATGGAGCTTATTACAGATAACA
AAGATTTCACTGGTATCAATACTAAGTTAAGTGGCAACACCCATTATACCCCACTTTGTGCTCCTACAAGTCCAAATAAGGCACTACCAG
AACTTAACCAAGATATGACCTGTACCAAAAATCCACAAAACTTAAACCAAATTCATGAGGAAACTGCAAAGAAAGCACAGAACTTGGTGC
TCCCCAACCGAAAGTCACCAAGCCCTGTAGCACCACATCCTTCAACCTTCGTAGCTACGCCAGCCTCCCATAATTTAGTCAATCAGACAA
ATGGGACAACAAAAGAGAGTGCTTTGCTGTTGCATGTGCTGTTGATGGTGCCAGATGGGAAAGATTTTATTAGTGGAGAATCTGAGAAAC
AATCACCATGCAATGTTTATTTAAATTGTAAACTCTTCAGCACAGAGGAAGTCACCAGATCTGTCATCGCATGGGGCACAACACAACCGG
TCTTTAACTTTTCTCAGGTGATTCCTGTCTCTCTGTCTTCCAAATACCTGGAAAGGCTTAAGAACAATGTGATGGTAATTGAAACTTGGA
ATAAGGTGCGGAGCCCAGGACAGGACAAGCTGCTCGGGCTGGTGAAACTTCCCCTCCACCAGTTTTACATGTCATTCAAAGATGCTAAGA
TTTCTCGCCTGCTGCTGGATGCCCAGTACCCAGTTGTTGCTGTCGACAGCTACATGCCTGTGATTGATGTGTTTTCAGGCCACCAAAATG
GGAGTCTTCGAGTCTTTTTAGCTATGGGTTCTTCAAATCAAATAATGGCACTACAAAGATTAAAGAATGAAGAAGGAACACTCCCTCCCT
TCAGCCCTAGGCCAGCCCATTTCCTGGACCAGCCAACTGCAGCATCTGTTGCTATGGCAGAGGACCGAGGAAATGGACTGATGGAGCACT
GCTTTGAGATCCATATAGAGATGGTTAAAGGGCTAGCCCCTCTTCAGGCAACAGTCTGGGGAGAAGCAGATTGTTATGTCCAGTACTACT
TTCCAGTTCAACACTCTCAATCCAGTGTGCTGAAAGGACCTGAGTTCCTTGAAAATGGAATTACTCTGAAGCCCTTCAGAACTGCAACCA
CACTCTGTGTTCCAGATCCCATCTTTAATAGTGAACACCATCACTCTCTCCTGTTGCCAGCTGAGGTTCCAGTGCAAAGGCTCCTACTAA
GTGCTTTCTCTGCACAGGGCCTCGTGCCTGGAGGTGGAGTCCAGTTTGAAATCTGGTGCAGATACTATTATCCTAATGTGAGAGACCAGA
AGGTCGCCAAAGGAACCTTGCCATTATCAAGGATCTGTGCTATGGTAACCACCCAGCATCGTGAGGATGTGGGAATACAGACCTTTAATC
TCCCTTTAACCCCCAGGATTGAGAACAGGAAAGAATTGAGGAACCAGTCATCAGGTTTACTGGATGTGGGCCTAAGGTACAGGCGTAGTC
CAAGAACAGCAGAGGGAGTTCTTGCTGCCCGAACTGTTTCCATCTCAGTCCAGATTATCAGAGCCTGTGGTCTGCAAGCAGCAGCCAAGG
CTTTGGCTGAACGGGAACCCGCTCTACAGTTTAGTGCCACAGTCGGGGTCAATGCCTCTGTCACCACTCATCTCTCCTTCCTGCCCCAGG
GAGAACAGCGCCGAACCCACCCTGTGGCCTGTTCTTTCTGCCCTGAGTTCTCCCATCACGTTGAGTTCACATGTAACTTGGTGACTCAGC
ACTGTAGTGGAGAGGCCTGTTTCCTAGCAGAGTTGTTGGAGTTTGCAGAAGTTATTTTTGCTGTCTATCATGAAAATACCAAGTCAGCAA
GTGATATAATCAGTATTGAGTCATGCAAAGAGTATCTGCTTGGAGTAGTAAAAGTTCCAACAAAAGAGCTGCTGATCAAGAGATCTGGGA
TCACAGGATGGTATCCTATCATTTTACCAGAAGACGGGGGCCTACCTCATGGCCTGGAGCTCATGCAGAAGATCGTGGGTGGTCTGGAGC
TTTCGATTTCCTTCACGCATCGTGGAGATAGAGAACGGGTGTTGGAAGCTGCTGAGCATTTGGGCTGGAGCTTTGAGAACAGCCTGAAAG
ATTTTGTCAGAATGGATGAAGGGGAGCCAGCCACTGTCACCATCTCCACCCCAAGGCTGTGGCTGCCCATCCATTGTGTGCTGCTTGCTG
GCCACAACCACATTCATAAGAATACATATTGCTACCTTCGCTACAAGTTCTATGATCATGAAGCCTTTTGGACCCCTCTCAAGAAGCCTA
AGGAATCTGTAAACAAAAAGCAGATTATGGTCACTTTCAAGGCATCCAAAAGAGCAGAAGTCACCAGGGGCCCATCACTGCTTTGGTACT
TCAGGGAGGAGAGGCTAGAGATCCAAGTGTGGCGAGCTTATGGCAATGACAGTGTGGAGAGACCCCATCAGACAGACAGCTGGATTGGCT
CAGCCTATGTGGACCTGGCCAGACTTGGGGAGAGGTCAGCGAGGACGCTAACTGTCAGTGGTGTGTATCCTCTGTTTGGACGAAATGCTT
CCAACCTCTCAGGAGCTGCCTTGCGAGTTCATGTGGTTCTTTCCTCTCTTTCCTCACACCTTGAGCCCACTCATGAGCTGGACTCCATGG
ACTGCAGCAGCCACAGTGAGTCTGAGCAGCTCCCCAGAAGGAATGATGAGGTCCAGCTCTCTCCACCAGAAGTCATCTCCTGCCACCAGA
AGTCTCCTGCCTCCACCCAGGTCCCCTGCAGCAGCACCACAGCTGAAGTCCGCCTGACGCAGGAGGGCCCTGCTGATTTGGATGGAACGT
TTGCAGTCAGCATCCTAGTAGAAAGAGCAATGCACTTGAGCTTGAAAGGGAGCCCCTTGACAGAGCGGAAAGTATCGATACCCAGTTGTT
GTGTATCCTTTGCAACAGCCGATGAGTCATCTCCTGTATACACCCAAGTGGTTGAAAACACAGATTCCCCCATCTGGAATTTTCAACAGC
AGTCAAGGCTATCAAAAGAGCTGCTTCTGGACCCACAACAAACCCTGGTCTTCAAAGTTTGGCATAAAGGAGATGAGGAGAGGGTGATTG
GCTTTGCCTCGGTGGACCTCTCCCCACTTCTCTCTGGCTTCCAGTTTGTCTGTGGCTGGTACAACATCACAGACTTCAGTGGAGAGTGCC
AGGGGCAGATAAAAGTTGCTGTCTCCCCTTTGGAGAGTTTGATACACTTCAAAGAAGAAAGGCAAGCAAGGCGTGGAGTGGAGACCTCAA
AATCACTGATCCCAATATACAGTCCCTTTTCCTTCCCTGCCTCTGATACGTATGCTGCATTCTCCAGCCACATGGCAAGGCAGACCCTAG
ACCAACTTGCTCATGCCTCCTCAAAGGAGCTTGATTTCTCCTCTCCTGGGAGAAGTGATACCACAAGAAGCCAAGCATCACGCCATGAAG
AGCATGTGCAGAACATTCGCCGGTTTCATGAATCCCTGCATCTTCAGGGAGAGGCACCCTTGCCATGTGATGACAAACTGACCACATCAC
CTTTGTCCTCCCAAACCTCCATTCTGACTTCTCTCAGGAAGAATCTGAGTGAGCTTGATCAGATTCAGAGGTACTTCCGCCAGAAGCTCA
CCAAGCCTTTCCTACCCCTCAGCCCTCAGACTCAAACGGCCATCTCACAGCACCAGGAGAGCTGTAGGGACCATCTTGGGCCAGGTGCCA
GCAGCCTAGACCCTGGGAGCCAGTGTATCCTGGAGAAATCCAGTAACCTGGTGTTGCAAGTCAGCTCCTTAATCACAGATCTGCAGACTA
TCACCAGGGATTCGCAAGCAGCTTTGAGTTCTCACCGAGCCAGGAGTAGAAGCAACAAGGCCACCACCCTCCCAGATGCTCAGGACACAG
AAGCACTGCAAGAACGATGCACAATGCCAGATGAGCCATTGGTAAGAGCTCCAGATAAAGGCACAGATTCCCCATCACCCCCTCCTCTCG
AAGAGACTTCAAATGGAGGAAGAATGCTCCATGAGTCCCTGAGGCATGCAGTACCCATTACAAGGATGCAGAGCAGTGAAGACACTGAGG
CAGGCCCAGCCTACAGTGATGAGGACTATGAAGAAGACATCATTGAGCCCAGGACCTTAAATGAGATCACCACGGTGACAGACAAAACTA
GCCCTTGGTCTAGTGTCATATCAGACACAAGTGAGGTCATCAGCCCTCAGCCTGACGAGGTGCAGAGGGAAGGCCCCTCTTGTCCTTCTC
CAGGGCCTTTCTGCAGAGAGGAGCTTATGGTCAAAAGTAGCTTTCTCTCCAGCCCAGAAAGGGCTGTCAACCCCCACCTGCCTAGGCAGG
GTTCTCCTAGCCAAAGTCTTGTTGCTTGTGAGTGTGAGGCCTCTAAGGCCAGGGTTGGTGGCGAGTCTGCCTCAGCCAACCCTCAGCCCA
TCCCATGCCCAACACTCTCAGGAGCTCAACAGAGCAGCACGTTTGTTGGATGGAGCTCACCACAGACAGATCAGAACAAGGAGCCCAAGT
CAGAGGCCCCAGCTGAGAATGAAGCTGCCACCAGTGAGCTCGGTGACTCTGCTGATAGCTTCAAGAAGTTGCCGCTAAATCTAGCCTCCC
AGAGCAGAAGGGAAAACCATAAGGGACCACCCATCGACTCCTCTGACATCAGGCAGAGGCAGGTGACAACTGGATCAGAGACGTCCACAA
AGCAGAGCCTCCTGCTCCCAGGGCCCATTGTGGTGCCCAACTTCTTTTTGCCTCCCCAGCAGTTGGAGGCTTCCCTGCGGATGCTTTCAC
TCTCAGCAACTTTGCCACCAGCAGCCACAACAGATCAGGTTCACAACCGAAATCTCCTATCTCTGGACTTTGATCGCGTAACACGCACAG
AGAAGATCTATGATGACCACCGCAAGTTCACCCTTCGGATTCTGTACGACCAGGCGGGGCGGCCCAGCCTCTGGTCACCCAGCAGCAGGC
TGAATGGTGTCAACGTGACATACTCCCCTGGGGGTTACATTGCTGGCATCCAGAGGGGCATCATGTCTGAAAGAATGGAATACGACCAGG
CGGGCCGCATCACATCCAGGATCTTCGCTGATGGGAAGACATGGAGCTACACATACTTAGAGAAGTCCATGGTGCTGCTACTACACAGCC
AGAGGCAGTATATCTTTGAGTTCGACAAGAATGACCGCCTCTCTTCTGTGACGATGCCCAACGTGGCGCGGCAGACACTAGAGACCATCC
GCTCAGTGGGCTACTACAGAAACATCTATCAGCCCCCTGAGGGCAATGCCTCAGTCATACAGGACTTCACTGAGGATGGGCACCTCCTTC
ACACCTTCTACCTGGGCACTGGCCGCAGGGTGATATACAAGTATGGCAAACTGTCAAAGCTGGCAGAGACGCTCTATGACACCACCAAGG
TCAGTTTCACCTATGACGAGACGGCAGGCATGCTGAAGACCATCAACCTACAGAATGAGGGCTTCACCTGCACCATCCGCTACCGTCAGA
TTGGGCCCCTGATTGACCGACAGATCTTCCGCTTCACTGAGGAAGGCATGGTCAACGCCCGTTTTGACTACAACTATGACAACAGCTTCC
GGGTGACCAGCATGCAGGCTGTGATCAACGAGACCCCACTGCCCATTGATCTCTATCGCTATGATGATGTGTCAGGCAAGACAGAGCAGT
TTGGGAAGTTTGGTGTCATTTACTATGACATTAACCAGATCATCACCACAGCTGTCATGACCCACACCAAGCATTTTGATGCATATGGCA
GGATGAAGGAAGTGCAGTATGAGATCTTCCGCTCGCTCATGTACTGGATGACCGTCCAGTATGATAACATGGGGCGAGTAGTGAAGAAGG
AGCTGAAGGTAGGACCCTACGCCAATACCACTCGCTACTCCTATGAGTATGATGCTGACGGCCAGCTGCAGACAGTCTCCATCAATGACA
AGCCACTCTGGCGCTACAGCTACGACCTCAATGGGAACCTGCACTTACTGAGCCCTGGGAACAGTGCACGGCTCACACCACTACGGTATG
ACATCCGCGACCGCATCACTCGGCTGGGTGACGTGCAATACAAGATGGATGAGGATGGCTTCCTGAGGCAGCGGGGCGGTGATATCTTTG
AGTACAACTCAGCTGGCCTGCTCATCAAGGCCTACAACCGGGCTGGCAGCTGGAGTGTCAGGTACCGCTACGATGGCCTGGGGCGGCGCG
TGTCCAGCAAGAGCAGCCACAGCCACCACCTGCAGTTCTTCTATGCAGACCTGACCAACCCCACCAAGGTCACCCACCTGTACAACCACT
CCAGCTCTGAGATCACCTCCCTCTACTACGACTTGCAAGGACACCTCTTTGCCATGGAGCTGAGCAGTGGTGATGAGTTTTACATAGCTT
GTGACAACATCGGGACCCCTCTTGCTGTCTTTAGTGGAACAGGTTTGATGATCAAGCAAATCCTGTACACAGCCTATGGGGAGATCTACA
TGGATACCAACCCCAACTTTCAGATCATCATAGGCTACCATGGTGGCCTCTATGATCCACTCACCAAGCTTGTCCACATGGGCCGGCGAG
ATTATGATGTGCTGGCCGGACGCTGGACTAGCCCAGACCACGAGCTGTGGAAGCACCTTAGTAGCAGCAACGTCATGCCTTTTAATCTCT
ATATGTTCAAAAACAACAACCCCATCAGCAACTCCCAGGACATCAAGTGCTTCATGACAGATGTTAACAGCTGGCTGCTCACCTTTGGAT
TCCAGCTACACAACGTGATCCCTGGTTATCCCAAACCAGACATGGATGCCATGGAACCCTCCTACGAGCTCATCCACACACAGATGAAAA
CGCAGGAGTGGGACAACAGCAAGTCTATCCTCGGGGTACAGTGTGAAGTACAGAAGCAGCTCAAGGCCTTTGTCACCTTAGAACGGTTTG
ACCAGCTCTATGGCTCCACAATCACCAGCTGCCAGCAGGCTCCAAAGACCAAGAAGTTTGCATCCAGCGGCTCAGTCTTTGGCAAGGGGG
TCAAGTTTGCCTTGAAGGATGGCCGAGTGACCACAGACATCATCAGTGTGGCCAATGAGGATGGGCGAAGGGTTGCTGCCATCTTGAACC
ATGCCCACTACCTAGAGAACCTGCACTTCACCATTGATGGGGTGGATACCCATTACTTTGTGAAACCAGGACCTTCAGAAGGTGACCTGG
CCATCCTGGGCCTCAGTGGGGGGCGGCGAACCCTGGAGAATGGGGTCAACGTCACTGTGTCCCAGATCAACACAGTACTTAATGGCAGGA
CTAGACGCTACACAGACATCCAGCTCCAGTACGGGGCACTGTGCTTGAACACACGCTACGGGACAACGTTGGATGAGGAGAAGGCACGGG
TCCTGGAGCTGGCCCGGCAGAGAGCCGTGCGCCAAGCGTGGGCCCGCGAGCAGCAGAGACTGCGGGAAGGGGAGGAAGGCCTGCGGGCCT
GGACAGAGGGGGAGAAGCAGCAGGTGCTGAGCACAGGGCGGGTGCAAGGCTACGACGGCTTTTTCGTGATCTCTGTCGAGCAGTACCCAG
AACTGTCAGACAGCGCCAACAACATCCACTTCATGAGACAGAGCGAGATGGGCCGGAGGTGACAGAGAGGACCAAGGACTTCTTGCCAAA
GACAGCTACTCTTTTGTGGCCGCATACCTGACTGTGTTGTACTTTTAAAAAAATGATTTTTTAACAAGTGCAGAAACAAAAAGATACTGG
TTGCATTGTAACTCATGCAACATCCTTTTTTTTAGAAAAGAAAAACACAGATTTGGCCTTCGCACATTTTTTGCAAAGAACAGAAGGTAT
TTTTTTCTGTAGTGTGATCACAATGAAAACTTTATTGTCTTTTGTTCCCTTTTTCCTTGAGGATTTTTCCCTTGTCGTTTGGGGTATGTA
TCTCCTCTCTGAGATGCATCTCCTGGGGTGTGTCCTCGTCTGTCCCTAGGTACCCAGTGTGATGTGGGACATGAATGTCTGTGCTAACTT
GTCTCATGTGCAACCCTTTCTTCTTCGACTGGGGTCGGGCAGGAGTAAAGGGAGTGATGGGCCAGTACAACACCCCTTCCAAGGGGGCCT
GGGAGGAGGGTCTGTAGGACCTGAGGCTCCTTGGCAGGGCTCCTGCAGAAGAGTGGTGGATTTCTTCTCACCTTGTTCTCTGCCTCCAGA
GGATCATAGATGGCTTCATCTTGCTCCAGGGAATTTCATGGTGTTGTTCAGCACCTTTTTTAAGCTGCCCCAAACTCCTGTTCAAGCTTT
CTATTTTGATGCTGAATGAAACCCCCTACCACTTTTGCAAATCCTGTGTAGTTGTCGGTGCCACCCCCATGCTGGGATAGAGAAAGTGTC
TCCCAGGTCCTTTCCCCCAGACCAGTGACATAACATCCTGGGCTCAGAGTCCCATCCTCCCGGGAGGGAAAGCACCCAGGATGCCTGTGA
TTGGTTGGTCCTCCATGATGTTCCTGTTCATCTCCTCCTTTCTCCCAAAGCCAGATGTGAGAACGAGCACTGCACAGCAAGCCTTCAATG
TGGGCACCATGTCCACAGAACAGAAGGCCACCCATGGCAAAGGCATGGCAGTGGTGGCGAGGGCACCAGCCTGCCTTCCGAGGCAAAGCC
CTCTCTCTATGACTTTGAGTATCTTCCCTCCACCACTCAGCCGCCACCACTGAGACGTAGGAATGTGGAGGGAGGTGCTTGGTGGCCTTT
GATTCTGGAAAAATGCTTAACAAAAAAAGCCAGCCAAAGAGAGGAAGGCATAAGCTAAGCATCCTTCTAACCAGTTCCCAAAGTCCCATC
TGCCTCCATGTACCAGCTGATCGCAGAGCTGGACTGGGGCAGGCTGGGCTTCCAGGAAATTCCTGAAGTTCTGAAACAGCTTCCCCTCTA
GAGAAGCCCACCCAATGTGTTTTTTAGTGACAGGAAGAAAGGAGGGAAGAGCTGATGTGGTGTGGCCTGCCCATATCATACAACCCCACC
AGGAGCAGGGCAGTTCCCAAGGTGGGTGCCCGTAGATCTGGGAGGCCAGGCTGGCATGATTCCTGTGAAGAACTGTGCCTGTGTCGTCAG
GGAGAGGCCTGAGCCCTCTCAGAAGCAGGGACAGCCCACACCTGAAGAGCACGCCCAAGCTGAGGCAGCAGCCAGCAGGCTGGGGGAGCA
GTGAGGGCAGGGGGAGTCACAGCCAGAGCTGGGAGCCCCTTGTTCAAGGATTCCATTCCTGGTTCATCCGCCTAATTACCATTGTCATTA
CCACTCACAGGAGGCTCTGGGAGATGGGAGGGGAAGCCAAATGCTTCCTTTTAAGCTGGGCTTCTTAGAAAATGGAACTTTTATGGGTTA
CATTTACATTAAGTGTGGAAAATGAATTCTGAGTCTGAGCTATTCCCCGTGGAAACCTTGTTGGACTGATAAGCTCATGGCACCTCTATA
GCCTTACTCACATAGTCTTCAGAATATTACACAAGTTAATGAAACTGAGAAGGTCTGACTGCATGAGGATCGGAGCAGCATGTAGTCTGG
GTTCTGCCTGGCAGAGGGAGGCAACCAAAACTTCTTGGGGAGAGGAGATTTCGCCTTAACGTCATCCCACTGGGATTAGAGGATGTGTTT
CGCTAAGTGCTCTTCCTGTTTCCAAAAAAAAAGCCACCCTGCTGCAGCAGTGCGCTTTGGCCTGCTTGTCCACTGGTTGCCCATTGCCCC
TGGATCCAGAGCTCTACTGAGTCAGATACAGTGCTCTGCAGGCCTGCTGTGGGAGGCATGAGCTGGAGATGGGGGCTCCCATCTGGCAGG
ATCATTCTTGGATGAGATGGAAAACAGTTTGGCCTGAAGAACACAAGTTTTGTCCTCCAGAAGGGACTTACGCCTCTCAAAATGTACTCT
TCATACCAAGGGCCCTTGGGCAAAGTGCTCCTGCCCAGTTGATCAGTCCCATCCTGGCTGCCTGACATCAGTGAAGACCTGCTGGGGATG
TCTGCTCAGAGGTCAGGAACGGCATGCGGTCCACAGGAACCAGCTCCCTACGCTTCCCCCACGCCCTGTCCCTCCTCCACAGCCCCCTCC
CCAAAGGAATAGGGTGGACTTTTAGGGATCAAAAACAGAATTATTGGGTGTTTCATTTATTTTTTTCTTTCTTTCTTTTTTTTTTCATAG
AGATGGGGTCTCACTATGTTGCCCAGGCTGTTCTCAAACTCCTGGCCTCAGGCGATCCACCTTGGCCTCCTGAAGTGCTGGGGTTACAGG
TGTGAGCCACTGCGCCTGGACTGAGTGTTTGTTTCTTTAAAGGATCTTATATTTTTCCTGTGCTACATACCACCACAGCAGCCCAGCTTC
TGTGGGGAGAGAAGTTGAAGGATCCCGAAGCTTTAGAAAAAGGATCTCAGCTGTGGCACAGGCAGTGTTATGCGCCTCACTGCCACATTG
GTGCTGTTGTATTGAAGGTGGTGCTTCTGGCCTTGGCCCTTTTGAGTTGGTTTCCATTTGGGCTGCAGGTGACTCAGTGACTCCCTCCTC
AAGCTGTCCTCCTGCTAAGACCAGCAGTCACAAACCCATGGCAAGGGTGAGTGTGAAGGCCTAACCCTGTGCCTATGTAATAGGCTCCAA
GCATCGACTCCCATCCTGAGAGGACCGGCCCTTTTGACACTCACCAACCAAATCTGTTCATTCGATAGAGTGACCAGGCCTCCCTCACCT
GCCCAGGTGTATGATCCTACAGTTCCTGCCTTCTCTCCTACCCCGCACAGCTGCCAACTGGTCCTACATCCTCAGCCCCTCTGCCACCAC
CTTAAATAGGACTTTACTGATTCCCCAACTTTGTTTTTTTGTAGGATGAGATTTCCTTTTTATCCCACCCCCCCACACCCCAAACAGACA
TTGCTGGAGGGCAGACTGGAGGAAGGGGAAGGCATGCAGGTAAATTACTGCCTTGTCAGCCTCTGACCCTCATCTCTCAGAATTGTTGGC
TGAGAATTAACCCAAGGACCACACCAGTGCCTGATTTCTACTTAGGGAGAGAGGATTGGAAACGATCCCTAAGAAACTGACTGAGGGTGA
GAATGGCCAGGAGGTGTGTGTCCAAATAACCAGGAGGGGGCACAGAAGATGATGGCAAGGCAGACTGGGCAGTGTTTTGTAGACACAGAA
CAAAGAATCAGAATTTGAAAAAAGAAGAAAAACAAATCTTCGCAGCTGCAACTTTAAAGTATCACCTTTATAGATGGCAGGGATTTCCAT
TATGCAAATGGAATCTAAGATTTCAATGTGAAATCTTAGAATGCAGTTTTACCACTTGCAGTCTTGTATTTGTGGTGGCCATGTGGTGAG
GGCGGTGATGCTGAGCTTTCTGCCCAGGAGGAATGAGCTTTCAAGCTCTCAGCAGGGTGTCAGGCTTGGGGATTTGAGCATCCACTGCTC
AAAGTCCAGGCTATTCTCCAGTCCTCACGGCAGCCACTAAGCCCAGGAGCCAGACCTGGCCCGGGGACACATCTCCTGAGGGATCCCAGA
AAGAACCCAGTCTTTCCTTTCCCTTGGGGTCCTTGTTAGAATGAAAACCTCTCTATTTAAGGCACATCATTCCCAGCTAGGTTTATACAC
TTGTCTATATTTTACTGGAGGAAAGGGAATTAAAAAAGAACTCTGCAGTTCAAGGCCCTTTCATTTAACCTTCCAAAAACAGCAAACTCA
TTTTAAAGACTCATTGCTGAGGTGATAGAGAGAAACCTTATCCTCTCCAACCTTCACATTCACAAAAACCATCCTTGTGTACTTGACTGC
CCTAGACAGTGGTGACTCTTAGGTTTCATTACGAATGTGGAATATCAGAGTGTGGGAAGGCCCAGGCGAGGGCCAATGTTGTGTTTCTTA
CCCCCTCTGGAATGCCAAAGGCAAGGTACTAGGTGACCTCCTGGTCCCCAAGAAAATGTGATTTATTCTGAGGGCGAACAGCCAAGGGAG
GACTAGTCTGGAGCACGCTCGGCCGTCCTGGCAGGAGCTGAGCCTCAGGTGTCTGGCGGTGCCCCAGCAGCCCTGGATTCACCCAACACC
AGAATCCCACTTTTCTAAATCCACCTGTTGTTCTGAGCACCTCTGAACCCGCAGCTTCGGCAAAAGGAGTCTGTACCAAGCTGCTTCTGG
ATGACCAACACTGGAGACTCTGGCCTTACCATGTGGAAATCATTTTCCTGAAGTCTGGAACTAATTTTGAGAAGTTTTTTTCTCAACACT
TTTGTGTTTCTAACACTGTATCTTGACTGTGTAAATACCAACAAGGCTGTAAATAAATGCAGATGTAGATACCTTCTAGAAAAAAAAAAG
CATAAAAACAAAACCAGAAGTGATCCCGTGTAGCCTTCGTTGACAAATAAAGACTATTTTGTGTTTACAGGTGTCTGGTGGCCTTTGCTT
GGAGATAAAGGCTTCCTCTTGCCTGTCCCAGCCCCCGAGCCATCCTGGGTTTGCACTTCCCTGCTGGCTGCTATCAGGATGACCTGGGAG
AGGACTCAGTCCTAGGCCCCAGGGTCCCTCTAAATCCCTCCAGGCTGCAGCTCTGTCAAGAGGGATGTCCAGAGGGTCTCTAAGACCCTG
AAGCTTGACTTTGCAATTGCATGACAGGAATAAATATCACAGCTCCTCTGACATCACTAGTGCAGCGTGGCTCCCCATCCCACTGCTGCC
CTCGTTCAGGGACAGGCTGAAGGGGCCAACGAACCCAACCCTCCCAGAGGAGGGAGCCTTGCTCCACCACTGGGCACACAGAGTCATCCA
CCATGCCACTGCCTTCCACAAGGGATGTGAGCCGTTGCACTTTAAAAATAAATGACTGTATATTCATCA

>11611_11611_1_C2CD3-TENM4_C2CD3_chr11_73739332_ENST00000334126_TENM4_chr11_78383374_ENST00000278550_length(amino acids)=3244AA_BP=2306
MKQRKGQGSGGSRGRKKRGLSDISPSTSLPPLVEGQLRCFLKLTVNRVIWKIAKPPTCVLVRVRWWGETSDGTLFCPRDALQTEPKAVRT
TTRYAIRCGPKQFTSYLTDMAVLVLEVITKLDGLPIGRVQINGLAQLSPTHQINGFFTIVSSTSKKLGELQVSLALEPLSETYDSYHPLP
TTDMTENVLLSKQGFRENTEPSSTQFQVPSRPRDIHTIKIDGKELAANSSRSTTPRGKDHVCFAENPDTIKDSSFGLQHSLNSGQSLESV
TLKGRAPRKQMSLLNSSEFQPQIRTVAKSHSDSCILSSNNLPTKDLLSALLEQGNKLRNAMVISAMKSSPETSMLLDQVHPPINEDSLRA
STQIRAFSRNRFKDHIEDHLLPSTENTFWRHDTKADTRAIQLLLGSAELSQGNFWDGLGSPPDSPSPGSDVYCISELNDPQYDQSLLENL
FYTAPKSDTSISDFLSEEDDIVPSKKISQSTALARSSKVLESSDHKLKKRSAGKRNRNLVEQQMLSETPEDAQTMTLSVDRLALLGRTHS
VRIIIETMGVPPDSPQMTPGKKSYAGPPPKVTTAKKRTFFVEYHFPVGFSESGLGKTALITEVVRLASSKITDGKVKFQQRFVFPVQFGG
PMIEHWWNSNLTFQIYVKKTPQKKPEVIGSVSLSLRAVIQSELLSFSDQLPVQQENGQSPFGPLKVTMELITDNKDFTGINTKLSGNTHY
TPLCAPTSPNKALPELNQDMTCTKNPQNLNQIHEETAKKAQNLVLPNRKSPSPVAPHPSTFVATPASHNLVNQTNGTTKESALLLHVLLM
VPDGKDFISGESEKQSPCNVYLNCKLFSTEEVTRSVIAWGTTQPVFNFSQVIPVSLSSKYLERLKNNVMVIETWNKVRSPGQDKLLGLVK
LPLHQFYMSFKDAKISRLLLDAQYPVVAVDSYMPVIDVFSGHQNGSLRVFLAMGSSNQIMALQRLKNEEGTLPPFSPRPAHFLDQPTAAS
VAMAEDRGNGLMEHCFEIHIEMVKGLAPLQATVWGEADCYVQYYFPVQHSQSSVLKGPEFLENGITLKPFRTATTLCVPDPIFNSEHHHS
LLLPAEVPVQRLLLSAFSAQGLVPGGGVQFEIWCRYYYPNVRDQKVAKGTLPLSRICAMVTTQHREDVGIQTFNLPLTPRIENRKELRNQ
SSGLLDVGLRYRRSPRTAEGVLAARTVSISVQIIRACGLQAAAKALAEREPALQFSATVGVNASVTTHLSFLPQGEQRRTHPVACSFCPE
FSHHVEFTCNLVTQHCSGEACFLAELLEFAEVIFAVYHENTKSASDIISIESCKEYLLGVVKVPTKELLIKRSGITGWYPIILPEDGGLP
HGLELMQKIVGGLELSISFTHRGDRERVLEAAEHLGWSFENSLKDFVRMDEGEPATVTISTPRLWLPIHCVLLAGHNHIHKNTYCYLRYK
FYDHEAFWTPLKKPKESVNKKQIMVTFKASKRAEVTRGPSLLWYFREERLEIQVWRAYGNDSVERPHQTDSWIGSAYVDLARLGERSART
LTVSGVYPLFGRNASNLSGAALRVHVVLSSLSSHLEPTHELDSMDCSSHSESEQLPRRNDEVQLSPPEVISCHQKSPASTQVPCSSTTAE
VRLTQEGPADLDGTFAVSILVERAMHLSLKGSPLTERKVSIPSCCVSFATADESSPVYTQVVENTDSPIWNFQQQSRLSKELLLDPQQTL
VFKVWHKGDEERVIGFASVDLSPLLSGFQFVCGWYNITDFSGECQGQIKVAVSPLESLIHFKEERQARRGVETSKSLIPIYSPFSFPASD
TYAAFSSHMARQTLDQLAHASSKELDFSSPGRSDTTRSQASRHEEHVQNIRRFHESLHLQGEAPLPCDDKLTTSPLSSQTSILTSLRKNL
SELDQIQRYFRQKLTKPFLPLSPQTQTAISQHQESCRDHLGPGASSLDPGSQCILEKSSNLVLQVSSLITDLQTITRDSQAALSSHRARS
RSNKATTLPDAQDTEALQERCTMPDEPLVRAPDKGTDSPSPPPLEETSNGGRMLHESLRHAVPITRMQSSEDTEAGPAYSDEDYEEDIIE
PRTLNEITTVTDKTSPWSSVISDTSEVISPQPDEVQREGPSCPSPGPFCREELMVKSSFLSSPERAVNPHLPRQGSPSQSLVACECEASK
ARVGGESASANPQPIPCPTLSGAQQSSTFVGWSSPQTDQNKEPKSEAPAENEAATSELGDSADSFKKLPLNLASQSRRENHKGPPIDSSD
IRQRQVTTGSETSTKQSLLLPGPIVVPNFFLPPQQLEASLRMLSLSATLPPAATTDQVHNRNLLSLDFDRVTRTEKIYDDHRKFTLRILY
DQAGRPSLWSPSSRLNGVNVTYSPGGYIAGIQRGIMSERMEYDQAGRITSRIFADGKTWSYTYLEKSMVLLLHSQRQYIFEFDKNDRLSS
VTMPNVARQTLETIRSVGYYRNIYQPPEGNASVIQDFTEDGHLLHTFYLGTGRRVIYKYGKLSKLAETLYDTTKVSFTYDETAGMLKTIN
LQNEGFTCTIRYRQIGPLIDRQIFRFTEEGMVNARFDYNYDNSFRVTSMQAVINETPLPIDLYRYDDVSGKTEQFGKFGVIYYDINQIIT
TAVMTHTKHFDAYGRMKEVQYEIFRSLMYWMTVQYDNMGRVVKKELKVGPYANTTRYSYEYDADGQLQTVSINDKPLWRYSYDLNGNLHL
LSPGNSARLTPLRYDIRDRITRLGDVQYKMDEDGFLRQRGGDIFEYNSAGLLIKAYNRAGSWSVRYRYDGLGRRVSSKSSHSHHLQFFYA
DLTNPTKVTHLYNHSSSEITSLYYDLQGHLFAMELSSGDEFYIACDNIGTPLAVFSGTGLMIKQILYTAYGEIYMDTNPNFQIIIGYHGG
LYDPLTKLVHMGRRDYDVLAGRWTSPDHELWKHLSSSNVMPFNLYMFKNNNPISNSQDIKCFMTDVNSWLLTFGFQLHNVIPGYPKPDMD
AMEPSYELIHTQMKTQEWDNSKSILGVQCEVQKQLKAFVTLERFDQLYGSTITSCQQAPKTKKFASSGSVFGKGVKFALKDGRVTTDIIS
VANEDGRRVAAILNHAHYLENLHFTIDGVDTHYFVKPGPSEGDLAILGLSGGRRTLENGVNVTVSQINTVLNGRTRRYTDIQLQYGALCL
NTRYGTTLDEEKARVLELARQRAVRQAWAREQQRLREGEEGLRAWTEGEKQQVLSTGRVQGYDGFFVISVEQYPELSDSANNIHFMRQSE
MGRR

--------------------------------------------------------------

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Fusion Gene PPI Analysis for C2CD3-TENM4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for C2CD3-TENM4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for C2CD3-TENM4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneC2CD3C0036069Saldino-Noonan Syndrome3GENOMICS_ENGLAND
HgeneC2CD3C1510460Orofaciodigital Syndrome I3CTD_human;GENOMICS_ENGLAND
HgeneC2CD3C4014780OROFACIODIGITAL SYNDROME XIV3CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
HgeneC2CD3C0026363Mohr Syndrome1CTD_human
HgeneC2CD3C0029294Orofaciodigital Syndromes1CTD_human
HgeneC2CD3C0238198Gastrointestinal Stromal Tumors1CTD_human
HgeneC2CD3C3179349Gastrointestinal Stromal Sarcoma1CTD_human
TgeneC0005586Bipolar Disorder1CTD_human
TgeneC0005587Depression, Bipolar1CTD_human
TgeneC0024713Manic Disorder1CTD_human
TgeneC0033975Psychotic Disorders1PSYGENET
TgeneC0036341Schizophrenia1PSYGENET
TgeneC0338831Manic1CTD_human
TgeneC0349204Nonorganic psychosis1PSYGENET
TgeneC4225223TREMOR, HEREDITARY ESSENTIAL, 51CTD_human;UNIPROT