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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:C2CD3-TENM4 (FusionGDB2 ID:HG26005TG26011)

Fusion Gene Summary for C2CD3-TENM4

Fusion gene summary

Fusion gene information	Fusion gene name: C2CD3-TENM4
	Fusion gene ID: hg26005tg26011
		Hgene	Tgene
	Gene symbol	C2CD3	TENM4
	Gene ID	26005	26011
	Gene name	C2 domain containing 3 centriole elongation regulator	teneurin transmembrane protein 4
	Synonyms	OFD14	Doc4\|ETM5\|ODZ4\|TEN4\|TNM4\|Ten-M4\|ten-4
	Cytomap	('C2CD3','C2CD3')('ODZ4','TENM4') 11q13.4	11q14.1
	Type of gene	protein-coding	protein-coding
	Description	C2 domain-containing protein 3C2 calcium dependent domain containing 3	teneurin-4odz, odd Oz/ten-m homolog 4protein Odd Oz/ten-m homolog 4tenascin-M4
	Modification date	20200329	20200313
	UniProtAcc	Q4AC94	.
	Ensembl transtripts involved in fusion gene	ENST00000334126, ENST00000542452, ENST00000313663, ENST00000539061,
Fusion gene scores	* DoF score	15 X 15 X 9=2025	17 X 17 X 9=2601
	# samples	18	18
	** MAII score	log2(18/2025*10)=-3.49185309632968 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(18/2601*10)=-3.85299758761332 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: C2CD3 [Title/Abstract] AND TENM4 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	C2CD3(73739332)-ODZ4(78383374), # samples:1 C2CD3(73739332)-TENM4(78383374), # samples:1
Anticipated loss of major functional domain due to fusion event.	C2CD3-TENM4 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. C2CD3-TENM4 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. C2CD3-TENM4 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. C2CD3-TENM4 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	C2CD3	GO:0061511	centriole elongation	24997988
Hgene	C2CD3	GO:0071539	protein localization to centrosome	24997988

Fusion gene breakpoints across C2CD3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across TENM4 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	BRCA	TCGA-A7-A4SB-01A	C2CD3	chr11	73739332	-	ODZ4	chr11	78383374	-
ChimerDB4	BRCA	TCGA-A7-A4SB-01A	C2CD3	chr11	73739332	-	TENM4	chr11	78383374	-

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Fusion Gene ORF analysis for C2CD3-TENM4

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000334126	ENST00000533038	C2CD3	chr11	73739332	-	TENM4	chr11	78383374	-
5UTR-3CDS	ENST00000542452	ENST00000278550	C2CD3	chr11	73739332	-	TENM4	chr11	78383374	-
5UTR-intron	ENST00000542452	ENST00000533038	C2CD3	chr11	73739332	-	TENM4	chr11	78383374	-
In-frame	ENST00000334126	ENST00000278550	C2CD3	chr11	73739332	-	TENM4	chr11	78383374	-
intron-3CDS	ENST00000313663	ENST00000278550	C2CD3	chr11	73739332	-	TENM4	chr11	78383374	-
intron-3CDS	ENST00000539061	ENST00000278550	C2CD3	chr11	73739332	-	TENM4	chr11	78383374	-
intron-intron	ENST00000313663	ENST00000533038	C2CD3	chr11	73739332	-	TENM4	chr11	78383374	-
intron-intron	ENST00000539061	ENST00000533038	C2CD3	chr11	73739332	-	TENM4	chr11	78383374	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000334126

C2CD3

chr11

73739332

ENST00000278550

TENM4

chr11

78383374

15189

7148

227

9961

3244

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000334126	ENST00000278550	C2CD3	chr11	73739332	-	TENM4	chr11	78383374	-	0.001383083	0.99861693

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Fusion Genomic Features for C2CD3-TENM4

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

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Fusion Protein Features for C2CD3-TENM4

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr11:73739332/chr11:78383374)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
C2CD3 Q4AC94	.
FUNCTION: Component of the centrioles that acts as a positive regulator of centriole elongation (PubMed:24997988). Promotes assembly of centriolar distal appendage, a structure at the distal end of the mother centriole that acts as an anchor of the cilium, and is required for recruitment of centriolar distal appendages proteins CEP83, SCLT1, CEP89, FBF1 and CEP164. Not required for centriolar satellite integrity or RAB8 activation. Required for primary cilium formation (PubMed:23769972). Required for sonic hedgehog/SHH signaling and for proteolytic processing of GLI3. {ECO:0000269\|PubMed:23769972, ECO:0000269\|PubMed:24997988}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

C2CD3

chr11:73739332

chr11:78383374

ENST00000334126

1171_1339

2307

2354.0

Domain

C2 4

Hgene

C2CD3

chr11:73739332

chr11:78383374

ENST00000334126

1403_1533

2307

2354.0

Domain

C2 5

Hgene

C2CD3

chr11:73739332

chr11:78383374

ENST00000334126

1617_1745

2307

2354.0

Domain

C2 6

Hgene

C2CD3

chr11:73739332

chr11:78383374

ENST00000334126

521_678

2307

2354.0

Domain

C2 1

Hgene

C2CD3

chr11:73739332

chr11:78383374

ENST00000334126

787_919

2307

2354.0

Domain

C2 2

Hgene

C2CD3

chr11:73739332

chr11:78383374

ENST00000334126

985_1147

2307

2354.0

Domain

C2 3

Tgene

TENM4

chr11:73739332

chr11:78383374

ENST00000278550

1887_1906

1832

2770.0

Repeat

Note=YD 5

Tgene

TENM4

chr11:73739332

chr11:78383374

ENST00000278550

1928_1946

1832

2770.0

Repeat

Note=YD 6

Tgene

TENM4

chr11:73739332

chr11:78383374

ENST00000278550

1947_1967

1832

2770.0

Repeat

Note=YD 7

Tgene

TENM4

chr11:73739332

chr11:78383374

ENST00000278550

1974_1991

1832

2770.0

Repeat

Note=YD 8

Tgene

TENM4

chr11:73739332

chr11:78383374

ENST00000278550

1992_2013

1832

2770.0

Repeat

Note=YD 9

Tgene

TENM4

chr11:73739332

chr11:78383374

ENST00000278550

2014_2031

1832

2770.0

Repeat

Note=YD 10

Tgene

TENM4

chr11:73739332

chr11:78383374

ENST00000278550

2034_2054

1832

2770.0

Repeat

Note=YD 11

Tgene

TENM4

chr11:73739332

chr11:78383374

ENST00000278550

2057_2077

1832

2770.0

Repeat

Note=YD 12

Tgene

TENM4

chr11:73739332

chr11:78383374

ENST00000278550

2085_2104

1832

2770.0

Repeat

Note=YD 13

Tgene

TENM4

chr11:73739332

chr11:78383374

ENST00000278550

2110_2127

1832

2770.0

Repeat

Note=YD 14

Tgene

TENM4

chr11:73739332

chr11:78383374

ENST00000278550

2128_2154

1832

2770.0

Repeat

Note=YD 15

Tgene

TENM4

chr11:73739332

chr11:78383374

ENST00000278550

2156_2169

1832

2770.0

Repeat

Note=YD 16

Tgene

TENM4

chr11:73739332

chr11:78383374

ENST00000278550

2170_2193

1832

2770.0

Repeat

Note=YD 17

Tgene

TENM4

chr11:73739332

chr11:78383374

ENST00000278550

2196_2216

1832

2770.0

Repeat

Note=YD 18

Tgene

TENM4

chr11:73739332

chr11:78383374

ENST00000278550

2217_2237

1832

2770.0

Repeat

Note=YD 19

Tgene

TENM4

chr11:73739332

chr11:78383374

ENST00000278550

2239_2259

1832

2770.0

Repeat

Note=YD 20

Tgene

TENM4

chr11:73739332

chr11:78383374

ENST00000278550

2271_2291

1832

2770.0

Repeat

Note=YD 21

Tgene

TENM4

chr11:73739332

chr11:78383374

ENST00000278550

2293_2313

1832

2770.0

Repeat

Note=YD 22

Tgene

TENM4

chr11:73739332

chr11:78383374

ENST00000278550

2339_2380

1832

2770.0

Repeat

Note=YD 23

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

C2CD3

chr11:73739332

chr11:78383374

ENST00000313663

1171_1339

1964.0

Domain

C2 4

Hgene

C2CD3

chr11:73739332

chr11:78383374

ENST00000313663

1403_1533

1964.0

Domain

C2 5

Hgene

C2CD3

chr11:73739332

chr11:78383374

ENST00000313663

1617_1745

1964.0

Domain

C2 6

Hgene

C2CD3

chr11:73739332

chr11:78383374

ENST00000313663

521_678

1964.0

Domain

C2 1

Hgene

C2CD3

chr11:73739332

chr11:78383374

ENST00000313663

787_919

1964.0

Domain

C2 2

Hgene

C2CD3

chr11:73739332

chr11:78383374

ENST00000313663

985_1147

1964.0

Domain

C2 3

Tgene

TENM4

chr11:73739332

chr11:78383374

ENST00000278550

179_182

1832

2770.0

Compositional bias

Note=Poly-Pro

Tgene

TENM4

chr11:73739332

chr11:78383374

ENST00000278550

1_341

1832

2770.0

Domain

Teneurin N-terminal

Tgene

TENM4

chr11:73739332

chr11:78383374

ENST00000278550

562_593

1832

2770.0

Domain

EGF-like 1

Tgene

TENM4

chr11:73739332

chr11:78383374

ENST00000278550

594_624

1832

2770.0

Domain

EGF-like 2

Tgene

TENM4

chr11:73739332

chr11:78383374

ENST00000278550

626_658

1832

2770.0

Domain

EGF-like 3

Tgene

TENM4

chr11:73739332

chr11:78383374

ENST00000278550

659_690

1832

2770.0

Domain

EGF-like 4

Tgene

TENM4

chr11:73739332

chr11:78383374

ENST00000278550

692_725

1832

2770.0

Domain

EGF-like 5

Tgene

TENM4

chr11:73739332

chr11:78383374

ENST00000278550

726_757

1832

2770.0

Domain

EGF-like 6

Tgene

TENM4

chr11:73739332

chr11:78383374

ENST00000278550

758_787

1832

2770.0

Domain

EGF-like 7

Tgene

TENM4

chr11:73739332

chr11:78383374

ENST00000278550

788_831

1832

2770.0

Domain

EGF-like 8

Tgene

TENM4

chr11:73739332

chr11:78383374

ENST00000278550

1216_1259

1832

2770.0

Repeat

Note=NHL 1

Tgene

TENM4

chr11:73739332

chr11:78383374

ENST00000278550

1264_1308

1832

2770.0

Repeat

Note=NHL 2

Tgene

TENM4

chr11:73739332

chr11:78383374

ENST00000278550

1334_1378

1832

2770.0

Repeat

Note=NHL 3

Tgene

TENM4

chr11:73739332

chr11:78383374

ENST00000278550

1393_1444

1832

2770.0

Repeat

Note=NHL 4

Tgene

TENM4

chr11:73739332

chr11:78383374

ENST00000278550

1523_1566

1832

2770.0

Repeat

Note=NHL 5

Tgene

TENM4

chr11:73739332

chr11:78383374

ENST00000278550

1576_1595

1832

2770.0

Repeat

Note=YD 1

Tgene

TENM4

chr11:73739332

chr11:78383374

ENST00000278550

1612_1632

1832

2770.0

Repeat

Note=YD 2

Tgene

TENM4

chr11:73739332

chr11:78383374

ENST00000278550

1675_1694

1832

2770.0

Repeat

Note=YD 3

Tgene

TENM4

chr11:73739332

chr11:78383374

ENST00000278550

1695_1717

1832

2770.0

Repeat

Note=YD 4

Tgene

TENM4

chr11:73739332

chr11:78383374

ENST00000278550

1_345

1832

2770.0

Topological domain

Cytoplasmic

Tgene

TENM4

chr11:73739332

chr11:78383374

ENST00000278550

367_2769

1832

2770.0

Topological domain

Extracellular

Tgene

TENM4

chr11:73739332

chr11:78383374

ENST00000278550

346_366

1832

2770.0

Transmembrane

Helical

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Fusion Gene Sequence for C2CD3-TENM4

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>11611_11611_1_C2CD3-TENM4_C2CD3_chr11_73739332_ENST00000334126_TENM4_chr11_78383374_ENST00000278550_length(transcript)=15189nt_BP=7148nt
AAAGCGTCCTGGGTATTGTAGTGTATTGGAGGGAAGGCGTCTTGGCGCCTTCTCTTCGCACCGTTTTCCGGAGACTGTTAGAGGAAGAGT
CGCTTTTTCCTGCCTCCCAGGCTGCCCAGCGGCGCCGGTTGCCGGGGAACGCAGGCGCCGTGGGGAGGGATGGCGGGAGGATACTGCTTA
GGTGCTGGAGACGGAGTTGAGCTGGTGAAGAAGAGCTCGGGCTCATCATGAAACAACGAAAAGGCCAAGGGTCTGGGGGCAGCCGTGGGC
GCAAAAAAAGAGGTTTAAGTGACATTTCTCCATCTACAAGCCTGCCACCTCTGGTTGAAGGCCAGCTACGCTGTTTTCTAAAACTTACTG
TTAATAGAGTCATATGGAAGATTGCAAAGCCTCCCACTTGTGTACTTGTCCGAGTGAGATGGTGGGGAGAAACATCAGATGGAACCCTCT
TTTGTCCCAGGGATGCATTGCAGACTGAACCAAAAGCTGTGAGAACAACTACACGTTACGCTATTCGTTGTGGTCCAAAACAGTTTACCT
CTTATCTAACAGATATGGCTGTGCTGGTGCTGGAAGTAATCACCAAACTTGATGGTCTTCCAATTGGTAGAGTTCAGATCAATGGACTAG
CTCAACTTTCTCCAACCCATCAAATCAATGGATTTTTTACCATTGTTTCATCAACGTCTAAGAAACTTGGAGAACTCCAGGTCTCACTTG
CCCTGGAACCTCTGTCAGAAACTTACGACAGCTACCATCCACTTCCTACCACTGACATGACAGAAAATGTGCTTTTATCTAAGCAGGGAT
TCAGAGAGAATACTGAACCCAGCAGTACCCAGTTTCAGGTTCCATCAAGGCCTCGCGACATACATACCATCAAAATTGATGGAAAAGAGT
TAGCAGCCAACAGCAGTAGATCAACCACTCCGAGGGGAAAAGACCATGTATGCTTTGCAGAGAACCCTGATACAATAAAGGATTCTTCCT
TTGGACTACAGCACAGTCTTAATTCAGGACAGAGTTTAGAGTCTGTAACTCTGAAAGGCAGAGCTCCACGGAAGCAGATGTCCCTTCTGA
ACAGTTCTGAATTCCAGCCTCAAATTAGAACAGTTGCCAAGAGTCACAGTGACTCATGCATTCTTTCTTCAAACAACCTCCCTACCAAGG
ATCTTCTTTCAGCTCTGTTAGAACAAGGCAATAAACTGCGTAATGCCATGGTGATTTCTGCAATGAAATCAAGCCCAGAGACCAGCATGT
TGTTGGACCAAGTTCATCCTCCTATTAATGAAGATTCTCTTAGAGCATCAACACAGATCAGAGCCTTTTCTAGGAATCGGTTTAAAGACC
ACATTGAAGATCACCTCCTCCCTTCAACTGAGAATACATTTTGGAGACATGACACAAAAGCTGATACCAGAGCTATACAGCTGCTATTAG
GCAGTGCTGAATTATCCCAAGGCAATTTCTGGGATGGGCTAGGCTCTCCTCCAGATTCCCCATCTCCTGGGAGTGATGTGTATTGCATCA
GTGAGCTGAATGACCCTCAGTATGACCAGAGTCTTCTGGAGAATTTATTTTATACAGCACCTAAATCTGATACCAGCATCAGTGATTTCC
TCAGTGAAGAGGATGATATCGTCCCTTCTAAAAAAATAAGCCAGTCAACAGCTCTTGCCAGATCATCTAAGGTTCTGGAGTCAAGTGATC
ATAAGCTGAAGAAGAGGTCAGCAGGCAAGAGAAATAGAAATTTGGTTGAACAACAGATGCTCTCAGAAACTCCAGAAGATGCCCAAACGA
TGACACTAAGTGTGGATAGACTGGCCCTTTTGGGTAGAACACATTCAGTCAGAATCATCATCGAAACCATGGGAGTTCCTCCAGATAGTC
CTCAGATGACCCCTGGCAAAAAAAGCTATGCTGGTCCACCACCTAAGGTGACTACAGCAAAAAAGCGCACTTTCTTTGTAGAATATCACT
TTCCTGTGGGCTTTTCGGAAAGCGGATTGGGAAAGACAGCTTTGATCACTGAGGTTGTTCGACTCGCCTCCAGTAAAATTACAGATGGAA
AGGTGAAGTTCCAGCAGCGATTTGTGTTTCCAGTACAGTTTGGTGGCCCAATGATAGAGCACTGGTGGAATTCCAACCTCACTTTCCAAA
TTTATGTAAAGAAAACTCCACAGAAAAAGCCAGAAGTCATTGGATCTGTGTCACTTTCTTTGCGAGCTGTCATTCAATCAGAGCTGCTTT
CTTTCAGTGATCAGCTTCCAGTGCAACAAGAAAATGGTCAGTCTCCATTTGGCCCCCTCAAGGTAACCATGGAGCTTATTACAGATAACA
AAGATTTCACTGGTATCAATACTAAGTTAAGTGGCAACACCCATTATACCCCACTTTGTGCTCCTACAAGTCCAAATAAGGCACTACCAG
AACTTAACCAAGATATGACCTGTACCAAAAATCCACAAAACTTAAACCAAATTCATGAGGAAACTGCAAAGAAAGCACAGAACTTGGTGC
TCCCCAACCGAAAGTCACCAAGCCCTGTAGCACCACATCCTTCAACCTTCGTAGCTACGCCAGCCTCCCATAATTTAGTCAATCAGACAA
ATGGGACAACAAAAGAGAGTGCTTTGCTGTTGCATGTGCTGTTGATGGTGCCAGATGGGAAAGATTTTATTAGTGGAGAATCTGAGAAAC
AATCACCATGCAATGTTTATTTAAATTGTAAACTCTTCAGCACAGAGGAAGTCACCAGATCTGTCATCGCATGGGGCACAACACAACCGG
TCTTTAACTTTTCTCAGGTGATTCCTGTCTCTCTGTCTTCCAAATACCTGGAAAGGCTTAAGAACAATGTGATGGTAATTGAAACTTGGA
ATAAGGTGCGGAGCCCAGGACAGGACAAGCTGCTCGGGCTGGTGAAACTTCCCCTCCACCAGTTTTACATGTCATTCAAAGATGCTAAGA
TTTCTCGCCTGCTGCTGGATGCCCAGTACCCAGTTGTTGCTGTCGACAGCTACATGCCTGTGATTGATGTGTTTTCAGGCCACCAAAATG
GGAGTCTTCGAGTCTTTTTAGCTATGGGTTCTTCAAATCAAATAATGGCACTACAAAGATTAAAGAATGAAGAAGGAACACTCCCTCCCT
TCAGCCCTAGGCCAGCCCATTTCCTGGACCAGCCAACTGCAGCATCTGTTGCTATGGCAGAGGACCGAGGAAATGGACTGATGGAGCACT
GCTTTGAGATCCATATAGAGATGGTTAAAGGGCTAGCCCCTCTTCAGGCAACAGTCTGGGGAGAAGCAGATTGTTATGTCCAGTACTACT
TTCCAGTTCAACACTCTCAATCCAGTGTGCTGAAAGGACCTGAGTTCCTTGAAAATGGAATTACTCTGAAGCCCTTCAGAACTGCAACCA
CACTCTGTGTTCCAGATCCCATCTTTAATAGTGAACACCATCACTCTCTCCTGTTGCCAGCTGAGGTTCCAGTGCAAAGGCTCCTACTAA
GTGCTTTCTCTGCACAGGGCCTCGTGCCTGGAGGTGGAGTCCAGTTTGAAATCTGGTGCAGATACTATTATCCTAATGTGAGAGACCAGA
AGGTCGCCAAAGGAACCTTGCCATTATCAAGGATCTGTGCTATGGTAACCACCCAGCATCGTGAGGATGTGGGAATACAGACCTTTAATC
TCCCTTTAACCCCCAGGATTGAGAACAGGAAAGAATTGAGGAACCAGTCATCAGGTTTACTGGATGTGGGCCTAAGGTACAGGCGTAGTC
CAAGAACAGCAGAGGGAGTTCTTGCTGCCCGAACTGTTTCCATCTCAGTCCAGATTATCAGAGCCTGTGGTCTGCAAGCAGCAGCCAAGG
CTTTGGCTGAACGGGAACCCGCTCTACAGTTTAGTGCCACAGTCGGGGTCAATGCCTCTGTCACCACTCATCTCTCCTTCCTGCCCCAGG
GAGAACAGCGCCGAACCCACCCTGTGGCCTGTTCTTTCTGCCCTGAGTTCTCCCATCACGTTGAGTTCACATGTAACTTGGTGACTCAGC
ACTGTAGTGGAGAGGCCTGTTTCCTAGCAGAGTTGTTGGAGTTTGCAGAAGTTATTTTTGCTGTCTATCATGAAAATACCAAGTCAGCAA
GTGATATAATCAGTATTGAGTCATGCAAAGAGTATCTGCTTGGAGTAGTAAAAGTTCCAACAAAAGAGCTGCTGATCAAGAGATCTGGGA
TCACAGGATGGTATCCTATCATTTTACCAGAAGACGGGGGCCTACCTCATGGCCTGGAGCTCATGCAGAAGATCGTGGGTGGTCTGGAGC
TTTCGATTTCCTTCACGCATCGTGGAGATAGAGAACGGGTGTTGGAAGCTGCTGAGCATTTGGGCTGGAGCTTTGAGAACAGCCTGAAAG
ATTTTGTCAGAATGGATGAAGGGGAGCCAGCCACTGTCACCATCTCCACCCCAAGGCTGTGGCTGCCCATCCATTGTGTGCTGCTTGCTG
GCCACAACCACATTCATAAGAATACATATTGCTACCTTCGCTACAAGTTCTATGATCATGAAGCCTTTTGGACCCCTCTCAAGAAGCCTA
AGGAATCTGTAAACAAAAAGCAGATTATGGTCACTTTCAAGGCATCCAAAAGAGCAGAAGTCACCAGGGGCCCATCACTGCTTTGGTACT
TCAGGGAGGAGAGGCTAGAGATCCAAGTGTGGCGAGCTTATGGCAATGACAGTGTGGAGAGACCCCATCAGACAGACAGCTGGATTGGCT
CAGCCTATGTGGACCTGGCCAGACTTGGGGAGAGGTCAGCGAGGACGCTAACTGTCAGTGGTGTGTATCCTCTGTTTGGACGAAATGCTT
CCAACCTCTCAGGAGCTGCCTTGCGAGTTCATGTGGTTCTTTCCTCTCTTTCCTCACACCTTGAGCCCACTCATGAGCTGGACTCCATGG
ACTGCAGCAGCCACAGTGAGTCTGAGCAGCTCCCCAGAAGGAATGATGAGGTCCAGCTCTCTCCACCAGAAGTCATCTCCTGCCACCAGA
AGTCTCCTGCCTCCACCCAGGTCCCCTGCAGCAGCACCACAGCTGAAGTCCGCCTGACGCAGGAGGGCCCTGCTGATTTGGATGGAACGT
TTGCAGTCAGCATCCTAGTAGAAAGAGCAATGCACTTGAGCTTGAAAGGGAGCCCCTTGACAGAGCGGAAAGTATCGATACCCAGTTGTT
GTGTATCCTTTGCAACAGCCGATGAGTCATCTCCTGTATACACCCAAGTGGTTGAAAACACAGATTCCCCCATCTGGAATTTTCAACAGC
AGTCAAGGCTATCAAAAGAGCTGCTTCTGGACCCACAACAAACCCTGGTCTTCAAAGTTTGGCATAAAGGAGATGAGGAGAGGGTGATTG
GCTTTGCCTCGGTGGACCTCTCCCCACTTCTCTCTGGCTTCCAGTTTGTCTGTGGCTGGTACAACATCACAGACTTCAGTGGAGAGTGCC
AGGGGCAGATAAAAGTTGCTGTCTCCCCTTTGGAGAGTTTGATACACTTCAAAGAAGAAAGGCAAGCAAGGCGTGGAGTGGAGACCTCAA
AATCACTGATCCCAATATACAGTCCCTTTTCCTTCCCTGCCTCTGATACGTATGCTGCATTCTCCAGCCACATGGCAAGGCAGACCCTAG
ACCAACTTGCTCATGCCTCCTCAAAGGAGCTTGATTTCTCCTCTCCTGGGAGAAGTGATACCACAAGAAGCCAAGCATCACGCCATGAAG
AGCATGTGCAGAACATTCGCCGGTTTCATGAATCCCTGCATCTTCAGGGAGAGGCACCCTTGCCATGTGATGACAAACTGACCACATCAC
CTTTGTCCTCCCAAACCTCCATTCTGACTTCTCTCAGGAAGAATCTGAGTGAGCTTGATCAGATTCAGAGGTACTTCCGCCAGAAGCTCA
CCAAGCCTTTCCTACCCCTCAGCCCTCAGACTCAAACGGCCATCTCACAGCACCAGGAGAGCTGTAGGGACCATCTTGGGCCAGGTGCCA
GCAGCCTAGACCCTGGGAGCCAGTGTATCCTGGAGAAATCCAGTAACCTGGTGTTGCAAGTCAGCTCCTTAATCACAGATCTGCAGACTA
TCACCAGGGATTCGCAAGCAGCTTTGAGTTCTCACCGAGCCAGGAGTAGAAGCAACAAGGCCACCACCCTCCCAGATGCTCAGGACACAG
AAGCACTGCAAGAACGATGCACAATGCCAGATGAGCCATTGGTAAGAGCTCCAGATAAAGGCACAGATTCCCCATCACCCCCTCCTCTCG
AAGAGACTTCAAATGGAGGAAGAATGCTCCATGAGTCCCTGAGGCATGCAGTACCCATTACAAGGATGCAGAGCAGTGAAGACACTGAGG
CAGGCCCAGCCTACAGTGATGAGGACTATGAAGAAGACATCATTGAGCCCAGGACCTTAAATGAGATCACCACGGTGACAGACAAAACTA
GCCCTTGGTCTAGTGTCATATCAGACACAAGTGAGGTCATCAGCCCTCAGCCTGACGAGGTGCAGAGGGAAGGCCCCTCTTGTCCTTCTC
CAGGGCCTTTCTGCAGAGAGGAGCTTATGGTCAAAAGTAGCTTTCTCTCCAGCCCAGAAAGGGCTGTCAACCCCCACCTGCCTAGGCAGG
GTTCTCCTAGCCAAAGTCTTGTTGCTTGTGAGTGTGAGGCCTCTAAGGCCAGGGTTGGTGGCGAGTCTGCCTCAGCCAACCCTCAGCCCA
TCCCATGCCCAACACTCTCAGGAGCTCAACAGAGCAGCACGTTTGTTGGATGGAGCTCACCACAGACAGATCAGAACAAGGAGCCCAAGT
CAGAGGCCCCAGCTGAGAATGAAGCTGCCACCAGTGAGCTCGGTGACTCTGCTGATAGCTTCAAGAAGTTGCCGCTAAATCTAGCCTCCC
AGAGCAGAAGGGAAAACCATAAGGGACCACCCATCGACTCCTCTGACATCAGGCAGAGGCAGGTGACAACTGGATCAGAGACGTCCACAA
AGCAGAGCCTCCTGCTCCCAGGGCCCATTGTGGTGCCCAACTTCTTTTTGCCTCCCCAGCAGTTGGAGGCTTCCCTGCGGATGCTTTCAC
TCTCAGCAACTTTGCCACCAGCAGCCACAACAGATCAGGTTCACAACCGAAATCTCCTATCTCTGGACTTTGATCGCGTAACACGCACAG
AGAAGATCTATGATGACCACCGCAAGTTCACCCTTCGGATTCTGTACGACCAGGCGGGGCGGCCCAGCCTCTGGTCACCCAGCAGCAGGC
TGAATGGTGTCAACGTGACATACTCCCCTGGGGGTTACATTGCTGGCATCCAGAGGGGCATCATGTCTGAAAGAATGGAATACGACCAGG
CGGGCCGCATCACATCCAGGATCTTCGCTGATGGGAAGACATGGAGCTACACATACTTAGAGAAGTCCATGGTGCTGCTACTACACAGCC
AGAGGCAGTATATCTTTGAGTTCGACAAGAATGACCGCCTCTCTTCTGTGACGATGCCCAACGTGGCGCGGCAGACACTAGAGACCATCC
GCTCAGTGGGCTACTACAGAAACATCTATCAGCCCCCTGAGGGCAATGCCTCAGTCATACAGGACTTCACTGAGGATGGGCACCTCCTTC
ACACCTTCTACCTGGGCACTGGCCGCAGGGTGATATACAAGTATGGCAAACTGTCAAAGCTGGCAGAGACGCTCTATGACACCACCAAGG
TCAGTTTCACCTATGACGAGACGGCAGGCATGCTGAAGACCATCAACCTACAGAATGAGGGCTTCACCTGCACCATCCGCTACCGTCAGA
TTGGGCCCCTGATTGACCGACAGATCTTCCGCTTCACTGAGGAAGGCATGGTCAACGCCCGTTTTGACTACAACTATGACAACAGCTTCC
GGGTGACCAGCATGCAGGCTGTGATCAACGAGACCCCACTGCCCATTGATCTCTATCGCTATGATGATGTGTCAGGCAAGACAGAGCAGT
TTGGGAAGTTTGGTGTCATTTACTATGACATTAACCAGATCATCACCACAGCTGTCATGACCCACACCAAGCATTTTGATGCATATGGCA
GGATGAAGGAAGTGCAGTATGAGATCTTCCGCTCGCTCATGTACTGGATGACCGTCCAGTATGATAACATGGGGCGAGTAGTGAAGAAGG
AGCTGAAGGTAGGACCCTACGCCAATACCACTCGCTACTCCTATGAGTATGATGCTGACGGCCAGCTGCAGACAGTCTCCATCAATGACA
AGCCACTCTGGCGCTACAGCTACGACCTCAATGGGAACCTGCACTTACTGAGCCCTGGGAACAGTGCACGGCTCACACCACTACGGTATG
ACATCCGCGACCGCATCACTCGGCTGGGTGACGTGCAATACAAGATGGATGAGGATGGCTTCCTGAGGCAGCGGGGCGGTGATATCTTTG
AGTACAACTCAGCTGGCCTGCTCATCAAGGCCTACAACCGGGCTGGCAGCTGGAGTGTCAGGTACCGCTACGATGGCCTGGGGCGGCGCG
TGTCCAGCAAGAGCAGCCACAGCCACCACCTGCAGTTCTTCTATGCAGACCTGACCAACCCCACCAAGGTCACCCACCTGTACAACCACT
CCAGCTCTGAGATCACCTCCCTCTACTACGACTTGCAAGGACACCTCTTTGCCATGGAGCTGAGCAGTGGTGATGAGTTTTACATAGCTT
GTGACAACATCGGGACCCCTCTTGCTGTCTTTAGTGGAACAGGTTTGATGATCAAGCAAATCCTGTACACAGCCTATGGGGAGATCTACA
TGGATACCAACCCCAACTTTCAGATCATCATAGGCTACCATGGTGGCCTCTATGATCCACTCACCAAGCTTGTCCACATGGGCCGGCGAG
ATTATGATGTGCTGGCCGGACGCTGGACTAGCCCAGACCACGAGCTGTGGAAGCACCTTAGTAGCAGCAACGTCATGCCTTTTAATCTCT
ATATGTTCAAAAACAACAACCCCATCAGCAACTCCCAGGACATCAAGTGCTTCATGACAGATGTTAACAGCTGGCTGCTCACCTTTGGAT
TCCAGCTACACAACGTGATCCCTGGTTATCCCAAACCAGACATGGATGCCATGGAACCCTCCTACGAGCTCATCCACACACAGATGAAAA
CGCAGGAGTGGGACAACAGCAAGTCTATCCTCGGGGTACAGTGTGAAGTACAGAAGCAGCTCAAGGCCTTTGTCACCTTAGAACGGTTTG
ACCAGCTCTATGGCTCCACAATCACCAGCTGCCAGCAGGCTCCAAAGACCAAGAAGTTTGCATCCAGCGGCTCAGTCTTTGGCAAGGGGG
TCAAGTTTGCCTTGAAGGATGGCCGAGTGACCACAGACATCATCAGTGTGGCCAATGAGGATGGGCGAAGGGTTGCTGCCATCTTGAACC
ATGCCCACTACCTAGAGAACCTGCACTTCACCATTGATGGGGTGGATACCCATTACTTTGTGAAACCAGGACCTTCAGAAGGTGACCTGG
CCATCCTGGGCCTCAGTGGGGGGCGGCGAACCCTGGAGAATGGGGTCAACGTCACTGTGTCCCAGATCAACACAGTACTTAATGGCAGGA
CTAGACGCTACACAGACATCCAGCTCCAGTACGGGGCACTGTGCTTGAACACACGCTACGGGACAACGTTGGATGAGGAGAAGGCACGGG
TCCTGGAGCTGGCCCGGCAGAGAGCCGTGCGCCAAGCGTGGGCCCGCGAGCAGCAGAGACTGCGGGAAGGGGAGGAAGGCCTGCGGGCCT
GGACAGAGGGGGAGAAGCAGCAGGTGCTGAGCACAGGGCGGGTGCAAGGCTACGACGGCTTTTTCGTGATCTCTGTCGAGCAGTACCCAG
AACTGTCAGACAGCGCCAACAACATCCACTTCATGAGACAGAGCGAGATGGGCCGGAGGTGACAGAGAGGACCAAGGACTTCTTGCCAAA
GACAGCTACTCTTTTGTGGCCGCATACCTGACTGTGTTGTACTTTTAAAAAAATGATTTTTTAACAAGTGCAGAAACAAAAAGATACTGG
TTGCATTGTAACTCATGCAACATCCTTTTTTTTAGAAAAGAAAAACACAGATTTGGCCTTCGCACATTTTTTGCAAAGAACAGAAGGTAT
TTTTTTCTGTAGTGTGATCACAATGAAAACTTTATTGTCTTTTGTTCCCTTTTTCCTTGAGGATTTTTCCCTTGTCGTTTGGGGTATGTA
TCTCCTCTCTGAGATGCATCTCCTGGGGTGTGTCCTCGTCTGTCCCTAGGTACCCAGTGTGATGTGGGACATGAATGTCTGTGCTAACTT
GTCTCATGTGCAACCCTTTCTTCTTCGACTGGGGTCGGGCAGGAGTAAAGGGAGTGATGGGCCAGTACAACACCCCTTCCAAGGGGGCCT
GGGAGGAGGGTCTGTAGGACCTGAGGCTCCTTGGCAGGGCTCCTGCAGAAGAGTGGTGGATTTCTTCTCACCTTGTTCTCTGCCTCCAGA
GGATCATAGATGGCTTCATCTTGCTCCAGGGAATTTCATGGTGTTGTTCAGCACCTTTTTTAAGCTGCCCCAAACTCCTGTTCAAGCTTT
CTATTTTGATGCTGAATGAAACCCCCTACCACTTTTGCAAATCCTGTGTAGTTGTCGGTGCCACCCCCATGCTGGGATAGAGAAAGTGTC
TCCCAGGTCCTTTCCCCCAGACCAGTGACATAACATCCTGGGCTCAGAGTCCCATCCTCCCGGGAGGGAAAGCACCCAGGATGCCTGTGA
TTGGTTGGTCCTCCATGATGTTCCTGTTCATCTCCTCCTTTCTCCCAAAGCCAGATGTGAGAACGAGCACTGCACAGCAAGCCTTCAATG
TGGGCACCATGTCCACAGAACAGAAGGCCACCCATGGCAAAGGCATGGCAGTGGTGGCGAGGGCACCAGCCTGCCTTCCGAGGCAAAGCC
CTCTCTCTATGACTTTGAGTATCTTCCCTCCACCACTCAGCCGCCACCACTGAGACGTAGGAATGTGGAGGGAGGTGCTTGGTGGCCTTT
GATTCTGGAAAAATGCTTAACAAAAAAAGCCAGCCAAAGAGAGGAAGGCATAAGCTAAGCATCCTTCTAACCAGTTCCCAAAGTCCCATC
TGCCTCCATGTACCAGCTGATCGCAGAGCTGGACTGGGGCAGGCTGGGCTTCCAGGAAATTCCTGAAGTTCTGAAACAGCTTCCCCTCTA
GAGAAGCCCACCCAATGTGTTTTTTAGTGACAGGAAGAAAGGAGGGAAGAGCTGATGTGGTGTGGCCTGCCCATATCATACAACCCCACC
AGGAGCAGGGCAGTTCCCAAGGTGGGTGCCCGTAGATCTGGGAGGCCAGGCTGGCATGATTCCTGTGAAGAACTGTGCCTGTGTCGTCAG
GGAGAGGCCTGAGCCCTCTCAGAAGCAGGGACAGCCCACACCTGAAGAGCACGCCCAAGCTGAGGCAGCAGCCAGCAGGCTGGGGGAGCA
GTGAGGGCAGGGGGAGTCACAGCCAGAGCTGGGAGCCCCTTGTTCAAGGATTCCATTCCTGGTTCATCCGCCTAATTACCATTGTCATTA
CCACTCACAGGAGGCTCTGGGAGATGGGAGGGGAAGCCAAATGCTTCCTTTTAAGCTGGGCTTCTTAGAAAATGGAACTTTTATGGGTTA
CATTTACATTAAGTGTGGAAAATGAATTCTGAGTCTGAGCTATTCCCCGTGGAAACCTTGTTGGACTGATAAGCTCATGGCACCTCTATA
GCCTTACTCACATAGTCTTCAGAATATTACACAAGTTAATGAAACTGAGAAGGTCTGACTGCATGAGGATCGGAGCAGCATGTAGTCTGG
GTTCTGCCTGGCAGAGGGAGGCAACCAAAACTTCTTGGGGAGAGGAGATTTCGCCTTAACGTCATCCCACTGGGATTAGAGGATGTGTTT
CGCTAAGTGCTCTTCCTGTTTCCAAAAAAAAAGCCACCCTGCTGCAGCAGTGCGCTTTGGCCTGCTTGTCCACTGGTTGCCCATTGCCCC
TGGATCCAGAGCTCTACTGAGTCAGATACAGTGCTCTGCAGGCCTGCTGTGGGAGGCATGAGCTGGAGATGGGGGCTCCCATCTGGCAGG
ATCATTCTTGGATGAGATGGAAAACAGTTTGGCCTGAAGAACACAAGTTTTGTCCTCCAGAAGGGACTTACGCCTCTCAAAATGTACTCT
TCATACCAAGGGCCCTTGGGCAAAGTGCTCCTGCCCAGTTGATCAGTCCCATCCTGGCTGCCTGACATCAGTGAAGACCTGCTGGGGATG
TCTGCTCAGAGGTCAGGAACGGCATGCGGTCCACAGGAACCAGCTCCCTACGCTTCCCCCACGCCCTGTCCCTCCTCCACAGCCCCCTCC
CCAAAGGAATAGGGTGGACTTTTAGGGATCAAAAACAGAATTATTGGGTGTTTCATTTATTTTTTTCTTTCTTTCTTTTTTTTTTCATAG
AGATGGGGTCTCACTATGTTGCCCAGGCTGTTCTCAAACTCCTGGCCTCAGGCGATCCACCTTGGCCTCCTGAAGTGCTGGGGTTACAGG
TGTGAGCCACTGCGCCTGGACTGAGTGTTTGTTTCTTTAAAGGATCTTATATTTTTCCTGTGCTACATACCACCACAGCAGCCCAGCTTC
TGTGGGGAGAGAAGTTGAAGGATCCCGAAGCTTTAGAAAAAGGATCTCAGCTGTGGCACAGGCAGTGTTATGCGCCTCACTGCCACATTG
GTGCTGTTGTATTGAAGGTGGTGCTTCTGGCCTTGGCCCTTTTGAGTTGGTTTCCATTTGGGCTGCAGGTGACTCAGTGACTCCCTCCTC
AAGCTGTCCTCCTGCTAAGACCAGCAGTCACAAACCCATGGCAAGGGTGAGTGTGAAGGCCTAACCCTGTGCCTATGTAATAGGCTCCAA
GCATCGACTCCCATCCTGAGAGGACCGGCCCTTTTGACACTCACCAACCAAATCTGTTCATTCGATAGAGTGACCAGGCCTCCCTCACCT
GCCCAGGTGTATGATCCTACAGTTCCTGCCTTCTCTCCTACCCCGCACAGCTGCCAACTGGTCCTACATCCTCAGCCCCTCTGCCACCAC
CTTAAATAGGACTTTACTGATTCCCCAACTTTGTTTTTTTGTAGGATGAGATTTCCTTTTTATCCCACCCCCCCACACCCCAAACAGACA
TTGCTGGAGGGCAGACTGGAGGAAGGGGAAGGCATGCAGGTAAATTACTGCCTTGTCAGCCTCTGACCCTCATCTCTCAGAATTGTTGGC
TGAGAATTAACCCAAGGACCACACCAGTGCCTGATTTCTACTTAGGGAGAGAGGATTGGAAACGATCCCTAAGAAACTGACTGAGGGTGA
GAATGGCCAGGAGGTGTGTGTCCAAATAACCAGGAGGGGGCACAGAAGATGATGGCAAGGCAGACTGGGCAGTGTTTTGTAGACACAGAA
CAAAGAATCAGAATTTGAAAAAAGAAGAAAAACAAATCTTCGCAGCTGCAACTTTAAAGTATCACCTTTATAGATGGCAGGGATTTCCAT
TATGCAAATGGAATCTAAGATTTCAATGTGAAATCTTAGAATGCAGTTTTACCACTTGCAGTCTTGTATTTGTGGTGGCCATGTGGTGAG
GGCGGTGATGCTGAGCTTTCTGCCCAGGAGGAATGAGCTTTCAAGCTCTCAGCAGGGTGTCAGGCTTGGGGATTTGAGCATCCACTGCTC
AAAGTCCAGGCTATTCTCCAGTCCTCACGGCAGCCACTAAGCCCAGGAGCCAGACCTGGCCCGGGGACACATCTCCTGAGGGATCCCAGA
AAGAACCCAGTCTTTCCTTTCCCTTGGGGTCCTTGTTAGAATGAAAACCTCTCTATTTAAGGCACATCATTCCCAGCTAGGTTTATACAC
TTGTCTATATTTTACTGGAGGAAAGGGAATTAAAAAAGAACTCTGCAGTTCAAGGCCCTTTCATTTAACCTTCCAAAAACAGCAAACTCA
TTTTAAAGACTCATTGCTGAGGTGATAGAGAGAAACCTTATCCTCTCCAACCTTCACATTCACAAAAACCATCCTTGTGTACTTGACTGC
CCTAGACAGTGGTGACTCTTAGGTTTCATTACGAATGTGGAATATCAGAGTGTGGGAAGGCCCAGGCGAGGGCCAATGTTGTGTTTCTTA
CCCCCTCTGGAATGCCAAAGGCAAGGTACTAGGTGACCTCCTGGTCCCCAAGAAAATGTGATTTATTCTGAGGGCGAACAGCCAAGGGAG
GACTAGTCTGGAGCACGCTCGGCCGTCCTGGCAGGAGCTGAGCCTCAGGTGTCTGGCGGTGCCCCAGCAGCCCTGGATTCACCCAACACC
AGAATCCCACTTTTCTAAATCCACCTGTTGTTCTGAGCACCTCTGAACCCGCAGCTTCGGCAAAAGGAGTCTGTACCAAGCTGCTTCTGG
ATGACCAACACTGGAGACTCTGGCCTTACCATGTGGAAATCATTTTCCTGAAGTCTGGAACTAATTTTGAGAAGTTTTTTTCTCAACACT
TTTGTGTTTCTAACACTGTATCTTGACTGTGTAAATACCAACAAGGCTGTAAATAAATGCAGATGTAGATACCTTCTAGAAAAAAAAAAG
CATAAAAACAAAACCAGAAGTGATCCCGTGTAGCCTTCGTTGACAAATAAAGACTATTTTGTGTTTACAGGTGTCTGGTGGCCTTTGCTT
GGAGATAAAGGCTTCCTCTTGCCTGTCCCAGCCCCCGAGCCATCCTGGGTTTGCACTTCCCTGCTGGCTGCTATCAGGATGACCTGGGAG
AGGACTCAGTCCTAGGCCCCAGGGTCCCTCTAAATCCCTCCAGGCTGCAGCTCTGTCAAGAGGGATGTCCAGAGGGTCTCTAAGACCCTG
AAGCTTGACTTTGCAATTGCATGACAGGAATAAATATCACAGCTCCTCTGACATCACTAGTGCAGCGTGGCTCCCCATCCCACTGCTGCC
CTCGTTCAGGGACAGGCTGAAGGGGCCAACGAACCCAACCCTCCCAGAGGAGGGAGCCTTGCTCCACCACTGGGCACACAGAGTCATCCA

>11611_11611_1_C2CD3-TENM4_C2CD3_chr11_73739332_ENST00000334126_TENM4_chr11_78383374_ENST00000278550_length(amino acids)=3244AA_BP=2306
MKQRKGQGSGGSRGRKKRGLSDISPSTSLPPLVEGQLRCFLKLTVNRVIWKIAKPPTCVLVRVRWWGETSDGTLFCPRDALQTEPKAVRT
TTRYAIRCGPKQFTSYLTDMAVLVLEVITKLDGLPIGRVQINGLAQLSPTHQINGFFTIVSSTSKKLGELQVSLALEPLSETYDSYHPLP
TTDMTENVLLSKQGFRENTEPSSTQFQVPSRPRDIHTIKIDGKELAANSSRSTTPRGKDHVCFAENPDTIKDSSFGLQHSLNSGQSLESV
TLKGRAPRKQMSLLNSSEFQPQIRTVAKSHSDSCILSSNNLPTKDLLSALLEQGNKLRNAMVISAMKSSPETSMLLDQVHPPINEDSLRA
STQIRAFSRNRFKDHIEDHLLPSTENTFWRHDTKADTRAIQLLLGSAELSQGNFWDGLGSPPDSPSPGSDVYCISELNDPQYDQSLLENL
FYTAPKSDTSISDFLSEEDDIVPSKKISQSTALARSSKVLESSDHKLKKRSAGKRNRNLVEQQMLSETPEDAQTMTLSVDRLALLGRTHS
VRIIIETMGVPPDSPQMTPGKKSYAGPPPKVTTAKKRTFFVEYHFPVGFSESGLGKTALITEVVRLASSKITDGKVKFQQRFVFPVQFGG
PMIEHWWNSNLTFQIYVKKTPQKKPEVIGSVSLSLRAVIQSELLSFSDQLPVQQENGQSPFGPLKVTMELITDNKDFTGINTKLSGNTHY
TPLCAPTSPNKALPELNQDMTCTKNPQNLNQIHEETAKKAQNLVLPNRKSPSPVAPHPSTFVATPASHNLVNQTNGTTKESALLLHVLLM
VPDGKDFISGESEKQSPCNVYLNCKLFSTEEVTRSVIAWGTTQPVFNFSQVIPVSLSSKYLERLKNNVMVIETWNKVRSPGQDKLLGLVK
LPLHQFYMSFKDAKISRLLLDAQYPVVAVDSYMPVIDVFSGHQNGSLRVFLAMGSSNQIMALQRLKNEEGTLPPFSPRPAHFLDQPTAAS
VAMAEDRGNGLMEHCFEIHIEMVKGLAPLQATVWGEADCYVQYYFPVQHSQSSVLKGPEFLENGITLKPFRTATTLCVPDPIFNSEHHHS
LLLPAEVPVQRLLLSAFSAQGLVPGGGVQFEIWCRYYYPNVRDQKVAKGTLPLSRICAMVTTQHREDVGIQTFNLPLTPRIENRKELRNQ
SSGLLDVGLRYRRSPRTAEGVLAARTVSISVQIIRACGLQAAAKALAEREPALQFSATVGVNASVTTHLSFLPQGEQRRTHPVACSFCPE
FSHHVEFTCNLVTQHCSGEACFLAELLEFAEVIFAVYHENTKSASDIISIESCKEYLLGVVKVPTKELLIKRSGITGWYPIILPEDGGLP
HGLELMQKIVGGLELSISFTHRGDRERVLEAAEHLGWSFENSLKDFVRMDEGEPATVTISTPRLWLPIHCVLLAGHNHIHKNTYCYLRYK
FYDHEAFWTPLKKPKESVNKKQIMVTFKASKRAEVTRGPSLLWYFREERLEIQVWRAYGNDSVERPHQTDSWIGSAYVDLARLGERSART
LTVSGVYPLFGRNASNLSGAALRVHVVLSSLSSHLEPTHELDSMDCSSHSESEQLPRRNDEVQLSPPEVISCHQKSPASTQVPCSSTTAE
VRLTQEGPADLDGTFAVSILVERAMHLSLKGSPLTERKVSIPSCCVSFATADESSPVYTQVVENTDSPIWNFQQQSRLSKELLLDPQQTL
VFKVWHKGDEERVIGFASVDLSPLLSGFQFVCGWYNITDFSGECQGQIKVAVSPLESLIHFKEERQARRGVETSKSLIPIYSPFSFPASD
TYAAFSSHMARQTLDQLAHASSKELDFSSPGRSDTTRSQASRHEEHVQNIRRFHESLHLQGEAPLPCDDKLTTSPLSSQTSILTSLRKNL
SELDQIQRYFRQKLTKPFLPLSPQTQTAISQHQESCRDHLGPGASSLDPGSQCILEKSSNLVLQVSSLITDLQTITRDSQAALSSHRARS
RSNKATTLPDAQDTEALQERCTMPDEPLVRAPDKGTDSPSPPPLEETSNGGRMLHESLRHAVPITRMQSSEDTEAGPAYSDEDYEEDIIE
PRTLNEITTVTDKTSPWSSVISDTSEVISPQPDEVQREGPSCPSPGPFCREELMVKSSFLSSPERAVNPHLPRQGSPSQSLVACECEASK
ARVGGESASANPQPIPCPTLSGAQQSSTFVGWSSPQTDQNKEPKSEAPAENEAATSELGDSADSFKKLPLNLASQSRRENHKGPPIDSSD
IRQRQVTTGSETSTKQSLLLPGPIVVPNFFLPPQQLEASLRMLSLSATLPPAATTDQVHNRNLLSLDFDRVTRTEKIYDDHRKFTLRILY
DQAGRPSLWSPSSRLNGVNVTYSPGGYIAGIQRGIMSERMEYDQAGRITSRIFADGKTWSYTYLEKSMVLLLHSQRQYIFEFDKNDRLSS
VTMPNVARQTLETIRSVGYYRNIYQPPEGNASVIQDFTEDGHLLHTFYLGTGRRVIYKYGKLSKLAETLYDTTKVSFTYDETAGMLKTIN
LQNEGFTCTIRYRQIGPLIDRQIFRFTEEGMVNARFDYNYDNSFRVTSMQAVINETPLPIDLYRYDDVSGKTEQFGKFGVIYYDINQIIT
TAVMTHTKHFDAYGRMKEVQYEIFRSLMYWMTVQYDNMGRVVKKELKVGPYANTTRYSYEYDADGQLQTVSINDKPLWRYSYDLNGNLHL
LSPGNSARLTPLRYDIRDRITRLGDVQYKMDEDGFLRQRGGDIFEYNSAGLLIKAYNRAGSWSVRYRYDGLGRRVSSKSSHSHHLQFFYA
DLTNPTKVTHLYNHSSSEITSLYYDLQGHLFAMELSSGDEFYIACDNIGTPLAVFSGTGLMIKQILYTAYGEIYMDTNPNFQIIIGYHGG
LYDPLTKLVHMGRRDYDVLAGRWTSPDHELWKHLSSSNVMPFNLYMFKNNNPISNSQDIKCFMTDVNSWLLTFGFQLHNVIPGYPKPDMD
AMEPSYELIHTQMKTQEWDNSKSILGVQCEVQKQLKAFVTLERFDQLYGSTITSCQQAPKTKKFASSGSVFGKGVKFALKDGRVTTDIIS
VANEDGRRVAAILNHAHYLENLHFTIDGVDTHYFVKPGPSEGDLAILGLSGGRRTLENGVNVTVSQINTVLNGRTRRYTDIQLQYGALCL
NTRYGTTLDEEKARVLELARQRAVRQAWAREQQRLREGEEGLRAWTEGEKQQVLSTGRVQGYDGFFVISVEQYPELSDSANNIHFMRQSE

--------------------------------------------------------------

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Fusion Gene PPI Analysis for C2CD3-TENM4

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for C2CD3-TENM4

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for C2CD3-TENM4

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Hgene	C2CD3	C0036069	Saldino-Noonan Syndrome	3	GENOMICS_ENGLAND
Hgene	C2CD3	C1510460	Orofaciodigital Syndrome I	3	CTD_human;GENOMICS_ENGLAND
Hgene	C2CD3	C4014780	OROFACIODIGITAL SYNDROME XIV	3	CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
Hgene	C2CD3	C0026363	Mohr Syndrome	1	CTD_human
Hgene	C2CD3	C0029294	Orofaciodigital Syndromes	1	CTD_human
Hgene	C2CD3	C0238198	Gastrointestinal Stromal Tumors	1	CTD_human
Hgene	C2CD3	C3179349	Gastrointestinal Stromal Sarcoma	1	CTD_human
Tgene		C0005586	Bipolar Disorder	1	CTD_human
Tgene		C0005587	Depression, Bipolar	1	CTD_human
Tgene		C0024713	Manic Disorder	1	CTD_human
Tgene		C0033975	Psychotic Disorders	1	PSYGENET
Tgene		C0036341	Schizophrenia	1	PSYGENET
Tgene		C0338831	Manic	1	CTD_human
Tgene		C0349204	Nonorganic psychosis	1	PSYGENET
Tgene		C4225223	TREMOR, HEREDITARY ESSENTIAL, 5	1	CTD_human;UNIPROT

Fusion Gene Studies in Kim Lab

Fusion gene:C2CD3-TENM4 (FusionGDB2 ID:HG26005TG26011)

Fusion Gene Summary for C2CD3-TENM4

Fusion Gene ORF analysis for C2CD3-TENM4

Fusion Genomic Features for C2CD3-TENM4

Fusion Protein Features for C2CD3-TENM4

Fusion Gene Sequence for C2CD3-TENM4

Fusion Gene PPI Analysis for C2CD3-TENM4

Related Drugs for C2CD3-TENM4

Related Diseases for C2CD3-TENM4

Fusion Gene Studies
in Kim Lab