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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:CNTNAP2-SPOCK3 (FusionGDB2 ID:HG26047TG50859)

Fusion Gene Summary for CNTNAP2-SPOCK3

check button Fusion gene summary
Fusion gene informationFusion gene name: CNTNAP2-SPOCK3
Fusion gene ID: hg26047tg50859
HgeneTgene
Gene symbol

CNTNAP2

SPOCK3

Gene ID

26047

50859

Gene namecontactin associated protein 2SPARC (osteonectin), cwcv and kazal like domains proteoglycan 3
SynonymsAUTS15|CASPR2|CDFE|NRXN4|PTHSL1HSAJ1454|TES-3|TICN3
Cytomap('CNTNAP2')('SPOCK3')

7q35-q36.1

4q32.3

Type of geneprotein-codingprotein-coding
Descriptioncontactin-associated protein-like 2cell recognition molecule Caspr2contactin associated protein like 2homolog of Drosophila neurexin IVtestican-3SPARC/osteonectin, cwcv and kazal like domains proteoglycan 3sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000361727, ENST00000463592, 
ENST00000538075, 
Fusion gene scores* DoF score19 X 23 X 2=8745 X 5 X 5=125
# samples 246
** MAII scorelog2(24/874*10)=-1.86459887389208
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(6/125*10)=-1.05889368905357
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CNTNAP2 [Title/Abstract] AND SPOCK3 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCNTNAP2(147336399)-SPOCK3(167675882), # samples:1
Anticipated loss of major functional domain due to fusion event.CNTNAP2-SPOCK3 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
CNTNAP2-SPOCK3 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
CNTNAP2-SPOCK3 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
CNTNAP2-SPOCK3 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across CNTNAP2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across SPOCK3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand


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Fusion Gene ORF analysis for CNTNAP2-SPOCK3

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000361727ENST00000357154CNTNAP2chr7147336399+SPOCK3chr4167675882-0.0001661860.9998338
ENST00000361727ENST00000357545CNTNAP2chr7147336399+SPOCK3chr4167675882-0.0001668330.9998331
ENST00000361727ENST00000504953CNTNAP2chr7147336399+SPOCK3chr4167675882-0.0001668330.9998331
ENST00000361727ENST00000511531CNTNAP2chr7147336399+SPOCK3chr4167675882-0.0001666470.99983335
ENST00000361727ENST00000506886CNTNAP2chr7147336399+SPOCK3chr4167675882-0.0001666470.99983335

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Fusion Genomic Features for CNTNAP2-SPOCK3


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for CNTNAP2-SPOCK3


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr7:147336399/chr4:167675882)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCNTNAP2chr7:147336399chr4:167675882ENST00000361727+1324216_3686991332.0DomainLaminin G-like 1
HgeneCNTNAP2chr7:147336399chr4:167675882ENST00000361727+1324401_5526991332.0DomainLaminin G-like 2
HgeneCNTNAP2chr7:147336399chr4:167675882ENST00000361727+1324554_5916991332.0DomainEGF-like 1
TgeneSPOCK3chr7:147336399chr4:167675882ENST00000357154712394_436239437.0Compositional biasNote=Asp-rich
TgeneSPOCK3chr7:147336399chr4:167675882ENST00000357545611394_436236434.0Compositional biasNote=Asp-rich
TgeneSPOCK3chr7:147336399chr4:167675882ENST00000421836712394_436188386.0Compositional biasNote=Asp-rich
TgeneSPOCK3chr7:147336399chr4:167675882ENST00000502330712394_436239437.0Compositional biasNote=Asp-rich
TgeneSPOCK3chr7:147336399chr4:167675882ENST00000504953611394_436236434.0Compositional biasNote=Asp-rich
TgeneSPOCK3chr7:147336399chr4:167675882ENST00000506886712394_436239437.0Compositional biasNote=Asp-rich
TgeneSPOCK3chr7:147336399chr4:167675882ENST00000510741510394_436196394.0Compositional biasNote=Asp-rich
TgeneSPOCK3chr7:147336399chr4:167675882ENST00000511269510394_436236434.0Compositional biasNote=Asp-rich
TgeneSPOCK3chr7:147336399chr4:167675882ENST00000511531712394_436239437.0Compositional biasNote=Asp-rich
TgeneSPOCK3chr7:147336399chr4:167675882ENST0000051264868394_436236314.0Compositional biasNote=Asp-rich
TgeneSPOCK3chr7:147336399chr4:167675882ENST0000051268138394_436141339.0Compositional biasNote=Asp-rich
TgeneSPOCK3chr7:147336399chr4:167675882ENST0000053494938394_436143341.0Compositional biasNote=Asp-rich
TgeneSPOCK3chr7:147336399chr4:167675882ENST00000541354510394_436119317.0Compositional biasNote=Asp-rich
TgeneSPOCK3chr7:147336399chr4:167675882ENST0000054163727394_436141339.0Compositional biasNote=Asp-rich
TgeneSPOCK3chr7:147336399chr4:167675882ENST00000357154712314_380239437.0DomainThyroglobulin type-1
TgeneSPOCK3chr7:147336399chr4:167675882ENST00000357545611314_380236434.0DomainThyroglobulin type-1
TgeneSPOCK3chr7:147336399chr4:167675882ENST00000421836712314_380188386.0DomainThyroglobulin type-1
TgeneSPOCK3chr7:147336399chr4:167675882ENST00000502330712314_380239437.0DomainThyroglobulin type-1
TgeneSPOCK3chr7:147336399chr4:167675882ENST00000504953611314_380236434.0DomainThyroglobulin type-1
TgeneSPOCK3chr7:147336399chr4:167675882ENST00000506886712314_380239437.0DomainThyroglobulin type-1
TgeneSPOCK3chr7:147336399chr4:167675882ENST00000510741510314_380196394.0DomainThyroglobulin type-1
TgeneSPOCK3chr7:147336399chr4:167675882ENST00000511269510314_380236434.0DomainThyroglobulin type-1
TgeneSPOCK3chr7:147336399chr4:167675882ENST00000511531712314_380239437.0DomainThyroglobulin type-1
TgeneSPOCK3chr7:147336399chr4:167675882ENST0000051264868314_380236314.0DomainThyroglobulin type-1
TgeneSPOCK3chr7:147336399chr4:167675882ENST0000051268138314_380141339.0DomainThyroglobulin type-1
TgeneSPOCK3chr7:147336399chr4:167675882ENST0000053494938314_380143341.0DomainThyroglobulin type-1
TgeneSPOCK3chr7:147336399chr4:167675882ENST00000541354510133_185119317.0DomainKazal-like
TgeneSPOCK3chr7:147336399chr4:167675882ENST00000541354510314_380119317.0DomainThyroglobulin type-1
TgeneSPOCK3chr7:147336399chr4:167675882ENST0000054163727314_380141339.0DomainThyroglobulin type-1

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCNTNAP2chr7:147336399chr4:167675882ENST00000361727+13241055_12146991332.0DomainLaminin G-like 4
HgeneCNTNAP2chr7:147336399chr4:167675882ENST00000361727+1324592_7986991332.0DomainFibrinogen C-terminal
HgeneCNTNAP2chr7:147336399chr4:167675882ENST00000361727+1324799_9636991332.0DomainLaminin G-like 3
HgeneCNTNAP2chr7:147336399chr4:167675882ENST00000361727+1324963_10026991332.0DomainEGF-like 2
HgeneCNTNAP2chr7:147336399chr4:167675882ENST00000361727+13241284_13316991332.0Topological domainCytoplasmic
HgeneCNTNAP2chr7:147336399chr4:167675882ENST00000361727+132428_12626991332.0Topological domainExtracellular
HgeneCNTNAP2chr7:147336399chr4:167675882ENST00000361727+13241263_12836991332.0TransmembraneHelical
TgeneSPOCK3chr7:147336399chr4:167675882ENST00000357154712133_185239437.0DomainKazal-like
TgeneSPOCK3chr7:147336399chr4:167675882ENST00000357545611133_185236434.0DomainKazal-like
TgeneSPOCK3chr7:147336399chr4:167675882ENST00000421836712133_185188386.0DomainKazal-like
TgeneSPOCK3chr7:147336399chr4:167675882ENST00000502330712133_185239437.0DomainKazal-like
TgeneSPOCK3chr7:147336399chr4:167675882ENST00000504953611133_185236434.0DomainKazal-like
TgeneSPOCK3chr7:147336399chr4:167675882ENST00000506886712133_185239437.0DomainKazal-like
TgeneSPOCK3chr7:147336399chr4:167675882ENST00000510741510133_185196394.0DomainKazal-like
TgeneSPOCK3chr7:147336399chr4:167675882ENST00000511269510133_185236434.0DomainKazal-like
TgeneSPOCK3chr7:147336399chr4:167675882ENST00000511531712133_185239437.0DomainKazal-like
TgeneSPOCK3chr7:147336399chr4:167675882ENST0000051264868133_185236314.0DomainKazal-like
TgeneSPOCK3chr7:147336399chr4:167675882ENST0000051268138133_185141339.0DomainKazal-like
TgeneSPOCK3chr7:147336399chr4:167675882ENST0000053494938133_185143341.0DomainKazal-like
TgeneSPOCK3chr7:147336399chr4:167675882ENST0000054163727133_185141339.0DomainKazal-like


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Fusion Gene Sequence for CNTNAP2-SPOCK3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>17917_17917_1_CNTNAP2-SPOCK3_CNTNAP2_chr7_147336399_ENST00000361727_SPOCK3_chr4_167675882_ENST00000357154_length(transcript)=4744nt_BP=2614nt
ACAAGCTCTCCATGTGAGCTGACAGGCGAGTGGAAACCCCTCGAGTCACGCTGCCCGGCGGCGGAGGGAGCGCTCGCCCGCAGTGGCAAC
AGCTGCACCACCGTCCCCGTCGCTCTGCCTTCCTCTTCTGCAGCCTCTGCTCTTCTGATTACCTCCCTCCCCCGTCCTTTGGTGATTTTT
TTTTTTCAAGAAGGAGAGGGCGGGGTAGGTGTCCGTTCCCTCCCCTCTTCCCCCTCCTTTGCCTTCTTGGTTTGAATTTCCTCCCCCGGC
GTTGCACTGGCACACAGTGCAAGAGGCAATACCCGCACGGAGGGAGAACGAAGGCTGAGACTCCCCTGCCGCTCCAAGCCCGGAAGAACT
GGAGCCTGGAGGGGGGTGAGGGGAGAAGAGGAAGCGGGAGGGGCTTGGCTTCCTCGCGTATTTGAGGACAGCCCATCTCCCTTCAAGAAC
CCTACGGAGAGTCGGACTGCATCTCCGCAGCGAGCTCTTGGAGCGCCGCCGGCCGGGAGGCGAAGGATGCAGGCGGCTCCGCGCGCCGGC
TGCGGGGCAGCGCTCCTGCTGTGGATTGTCAGCAGCTGCCTCTGCAGAGCCTGGACGGCTCCCTCCACGTCCCAAAAATGTGATGAGCCA
CTTGTCTCTGGACTCCCCCATGTGGCTTTCAGCAGCTCCTCCTCCATCTCTGGTAGCTATTCTCCCGGCTATGCCAAGATAAACAAGAGA
GGAGGTGCTGGGGGATGGTCTCCATCAGACAGCGACCATTATCAATGGCTTCAGGTTGACTTTGGCAATCGGAAGCAGATCAGTGCCATT
GCAACCCAAGGAAGGTATAGCAGCTCAGATTGGGTGACCCAATACCGGATGCTCTACAGCGACACAGGGAGAAACTGGAAACCCTATCAT
CAAGATGGGAATATCTGGGCATTTCCCGGAAACATTAACTCTGACGGTGTGGTCCGGCACGAATTACAGCATCCGATTATTGCCCGCTAT
GTGCGCATAGTGCCTCTGGATTGGAATGGAGAAGGTCGCATTGGACTCAGAATTGAAGTTTATGGCTGTTCTTACTGGGCTGATGTTATC
AACTTTGATGGCCATGTTGTATTACCATATAGATTCAGAAACAAGAAGATGAAAACACTGAAAGATGTCATTGCCTTGAACTTTAAGACG
TCTGAAAGTGAAGGAGTAATCCTGCACGGAGAAGGACAGCAAGGAGATTACATTACCTTGGAACTGAAAAAAGCCAAGCTGGTCCTCAGT
TTAAACTTAGGAAGCAACCAGCTTGGCCCCATATATGGCCACACATCAGTGATGACAGGAAGTTTGCTGGATGACCACCACTGGCACTCT
GTGGTCATTGAGCGCCAGGGGCGGAGCATTAACCTCACTCTGGACAGGAGCATGCAGCACTTCCGTACCAATGGAGAGTTTGACTACCTG
GACTTGGACTATGAGATAACCTTTGGAGGCATCCCTTTCTCTGGCAAGCCCAGCTCCAGCAGTAGAAAGAATTTCAAAGGCTGCATGGAA
AGCATCAACTACAATGGCGTCAACATTACTGATCTTGCCAGAAGGAAGAAATTAGAGCCCTCAAATGTGGGAAATTTGAGCTTTTCTTGT
GTGGAACCCTATACGGTGCCTGTCTTTTTCAACGCTACAAGTTACCTGGAGGTGCCCGGACGGCTTAACCAGGACCTGTTCTCAGTCAGT
TTCCAGTTTAGGACATGGAACCCCAATGGTCTCCTGGTCTTCAGTCACTTTGCGGATAATTTGGGCAATGTGGAGATTGACCTCACTGAA
AGCAAAGTGGGTGTTCACATCAACATCACACAGACCAAGATGAGCCAAATCGATATTTCCTCAGGTTCTGGGTTGAATGATGGACAGTGG
CACGAGGTTCGCTTCCTAGCCAAGGAAAATTTTGCTATTCTCACCATCGATGGAGATGAAGCATCAGCAGTTCGAACTAATAGTCCCCTT
CAAGTTAAAACTGGCGAGAAGTACTTTTTTGGAGGTTTTCTGAACCAGATGAATAACTCAAGTCACTCTGTCCTTCAGCCTTCATTCCAA
GGATGCATGCAGCTCATTCAAGTGGACGATCAACTTGTAAATTTATACGAAGTGGCACAAAGGAAGCCGGGAAGTTTCGCGAATGTCAGC
ATTGACATGTGTGCGATCATAGACAGATGTGTGCCCAATCACTGTGAGCATGGTGGAAAGTGCTCGCAAACATGGGACAGCTTCAAATGC
ACTTGTGATGAGACAGGATACAGTGGGGCCACCTGCCACAACTCTATCTACGAGCCTTCCTGTGAAGCCTACAAACACCTAGGACAGACA
TCAAATTATTACTGGATAGATCCTGATGGCAGCGGACCTCTGGGGCCTCTGAAAGTTTACTGCAACATGACAGAGGACAAAGTGTGGACC
ATAGTGTCTCATGACTTGCAGATGCAGACGCCTGTGGTCGGCTACAACCCAGAAAAATACTCAGTGACACAGCTCGTTTACAGCGCCTCC
ATGGACCAGATAAGTGCCATCACTGACAGTGCCGAGTACTGCGAGCAGTATGTCTCCTATTTCTGCAAGATGTCAAGATTGTTGAACACC
CCAGGATTCGATACCAGCATCTTGCCAATTTGCAAGGACTCACTTGGCTGGATGTTTAACAGACTTGATACAAACTATGACCTGCTATTG
GACCAGTCAGAGCTCAGAAGCATTTACCTTGATAAGAATGAACAGTGTACCAAGGCATTCTTCAATTCTTGTGACACATACAAGGACAGT
TTAATATCTAATAATGAGTGGTGCTACTGCTTCCAGAGACAGCAAGACCCACCTTGCCAGACTGAGCTCAGCAATATTCAGAAGCGGCAA
GGGGTAAAGAAGCTCCTAGGACAGTATATCCCCCTGTGTGATGAAGATGGTTACTACAAGCCAACACAATGTCATGGCAGTGTTGGACAG
TGCTGGTGTGTTGACAGATATGGAAATGAAGTCATGGGATCCAGAATAAATGGTGTTGCAGATTGTGCTATAGATTTTGAGATCTCCGGA
GATTTTGCTAGTGGCGATTTTCATGAATGGACTGATGATGAGGATGATGAAGACGATATTATGAATGATGAAGATGAAATTGAAGATGAT
GATGAAGATGAAGGGGATGATGATGATGGTGGTGATGACCATGATGTATACATTTGATTGATGACAGTTGAAATCAATAAATTCTACATT
TCTAATATTTACAAAAATGATAGCCTATTTAAAATTATCTTCTTCCCCAATAACAAAATGATTCTAAACCTCACATATATTTTGTATAAT
TATTTGAAAAATTGCAGCTAAAGTTATAGAACTTTATGTTTAAATAAGAATCATTTGCTTTGAGTTTTTATATTCCTTACACAAAAAGAA
AATACATATGCAGTCTAGTCAGACAAAATAAAGTTTTGAAGTGCTACTATAATAAGTTTTTCACGAGAACAAACTTTGTAAATCTTCCAT
AAGCAAAATGACAGCTAGTGCTTGGGATCGTACATGTTAATTTTCTGAAAGATAATTCTAAGTGAAATTTAAAATAAATAAATTTTTAAT
GACCTGGGTCTTAAGGATTTAGGAAAAATATGCATGCTTTAATTGCATTTCCAAAGTAGCATCTTGCTAGACCTAGTTGAGTCAGGATAA
CAGAGAGATACCACATGGCAAGAAAAACAAAGTGACAATTGTAGAGTCCTCAATTGTGTTTACATTAATAGTGGTGTTTTTACCTATGAA
ATTATTCTGGATCTAATAGGACATTTTACAAAATGGCAAGTATGGAAAACCATGGATTCTGAAAGTTAAAAATTTAGTTGTTCTCCCCAA
TGTGTATTTTAATTTGGATGGCAGTCTCATGCAGATTTTTTAAAAGATTCTTTAATAACATGATTTGTTTGCCTTTCTAGATTTCTTTAT
CTTTCTGACCAGCAACTTAGGGAGCAGAATTTAAATTAGGAAGACAAAGGGAAAGATTCATTTAAACCATATTTTTACAAAGTTTGTCAT
TTGCCCCAAGGTCAAATTTTAAATTCTTAATTTTCATTTTATTTCCCATTTTAGGTAAAAGTTTGCATTTAATCTTAGAATTATGTTATT
TTTGTTAGTAGTGTGGAAACTTAGAGAACTTATTGTATGGTGCCTTGCAAAAATAGAGATAGAAAGATTTTAGCATGCATACCAATATAG
TATATTACGCAATATATAAGCACACCTAATTAACAGATTAATATCAGTAAAGGTATTGCTGCTGGAATGAAGAAAATGGGATACGTTTGT
TTCTTTTTTTCTATTGTTACATAATTGCCATGTGGACTTGTTTATGATTATTGTGTAGAGTAGCATTTAAGATTTAACTGTAGCAAAAAT
TACTTTAACCGCTGTATTTAAGTTAGCATGTTAATTAATTGTGTAGACATTTTGGCACACCATCACTTTTAACTATATCATACCAATGGT
TTTGTGCCCATAATAAAAATGGAAAAACCTGTTGAATGTTACGTATTGGTATCTTTAATTTCAACAGTGGGTAAACTGGTTTCCCAGTAT
ACAATTCATTGAAAGCAAAATTGATTAATTATTTCCATTTAATTTATACACACTCAATACAAAATTTAATGTTGACTTTACGTAATAAAG

>17917_17917_1_CNTNAP2-SPOCK3_CNTNAP2_chr7_147336399_ENST00000361727_SPOCK3_chr4_167675882_ENST00000357154_length(amino acids)=976AA_BP=779
MAHSARGNTRTEGERRLRLPCRSKPGRTGAWRGVRGEEEAGGAWLPRVFEDSPSPFKNPTESRTASPQRALGAPPAGRRRMQAAPRAGCG
AALLLWIVSSCLCRAWTAPSTSQKCDEPLVSGLPHVAFSSSSSISGSYSPGYAKINKRGGAGGWSPSDSDHYQWLQVDFGNRKQISAIAT
QGRYSSSDWVTQYRMLYSDTGRNWKPYHQDGNIWAFPGNINSDGVVRHELQHPIIARYVRIVPLDWNGEGRIGLRIEVYGCSYWADVINF
DGHVVLPYRFRNKKMKTLKDVIALNFKTSESEGVILHGEGQQGDYITLELKKAKLVLSLNLGSNQLGPIYGHTSVMTGSLLDDHHWHSVV
IERQGRSINLTLDRSMQHFRTNGEFDYLDLDYEITFGGIPFSGKPSSSSRKNFKGCMESINYNGVNITDLARRKKLEPSNVGNLSFSCVE
PYTVPVFFNATSYLEVPGRLNQDLFSVSFQFRTWNPNGLLVFSHFADNLGNVEIDLTESKVGVHINITQTKMSQIDISSGSGLNDGQWHE
VRFLAKENFAILTIDGDEASAVRTNSPLQVKTGEKYFFGGFLNQMNNSSHSVLQPSFQGCMQLIQVDDQLVNLYEVAQRKPGSFANVSID
MCAIIDRCVPNHCEHGGKCSQTWDSFKCTCDETGYSGATCHNSIYEPSCEAYKHLGQTSNYYWIDPDGSGPLGPLKVYCNMTEDKVWTIV
SHDLQMQTPVVGYNPEKYSVTQLVYSASMDQISAITDSAEYCEQYVSYFCKMSRLLNTPGFDTSILPICKDSLGWMFNRLDTNYDLLLDQ
SELRSIYLDKNEQCTKAFFNSCDTYKDSLISNNEWCYCFQRQQDPPCQTELSNIQKRQGVKKLLGQYIPLCDEDGYYKPTQCHGSVGQCW

--------------------------------------------------------------
>17917_17917_2_CNTNAP2-SPOCK3_CNTNAP2_chr7_147336399_ENST00000361727_SPOCK3_chr4_167675882_ENST00000357545_length(transcript)=4741nt_BP=2614nt
ACAAGCTCTCCATGTGAGCTGACAGGCGAGTGGAAACCCCTCGAGTCACGCTGCCCGGCGGCGGAGGGAGCGCTCGCCCGCAGTGGCAAC
AGCTGCACCACCGTCCCCGTCGCTCTGCCTTCCTCTTCTGCAGCCTCTGCTCTTCTGATTACCTCCCTCCCCCGTCCTTTGGTGATTTTT
TTTTTTCAAGAAGGAGAGGGCGGGGTAGGTGTCCGTTCCCTCCCCTCTTCCCCCTCCTTTGCCTTCTTGGTTTGAATTTCCTCCCCCGGC
GTTGCACTGGCACACAGTGCAAGAGGCAATACCCGCACGGAGGGAGAACGAAGGCTGAGACTCCCCTGCCGCTCCAAGCCCGGAAGAACT
GGAGCCTGGAGGGGGGTGAGGGGAGAAGAGGAAGCGGGAGGGGCTTGGCTTCCTCGCGTATTTGAGGACAGCCCATCTCCCTTCAAGAAC
CCTACGGAGAGTCGGACTGCATCTCCGCAGCGAGCTCTTGGAGCGCCGCCGGCCGGGAGGCGAAGGATGCAGGCGGCTCCGCGCGCCGGC
TGCGGGGCAGCGCTCCTGCTGTGGATTGTCAGCAGCTGCCTCTGCAGAGCCTGGACGGCTCCCTCCACGTCCCAAAAATGTGATGAGCCA
CTTGTCTCTGGACTCCCCCATGTGGCTTTCAGCAGCTCCTCCTCCATCTCTGGTAGCTATTCTCCCGGCTATGCCAAGATAAACAAGAGA
GGAGGTGCTGGGGGATGGTCTCCATCAGACAGCGACCATTATCAATGGCTTCAGGTTGACTTTGGCAATCGGAAGCAGATCAGTGCCATT
GCAACCCAAGGAAGGTATAGCAGCTCAGATTGGGTGACCCAATACCGGATGCTCTACAGCGACACAGGGAGAAACTGGAAACCCTATCAT
CAAGATGGGAATATCTGGGCATTTCCCGGAAACATTAACTCTGACGGTGTGGTCCGGCACGAATTACAGCATCCGATTATTGCCCGCTAT
GTGCGCATAGTGCCTCTGGATTGGAATGGAGAAGGTCGCATTGGACTCAGAATTGAAGTTTATGGCTGTTCTTACTGGGCTGATGTTATC
AACTTTGATGGCCATGTTGTATTACCATATAGATTCAGAAACAAGAAGATGAAAACACTGAAAGATGTCATTGCCTTGAACTTTAAGACG
TCTGAAAGTGAAGGAGTAATCCTGCACGGAGAAGGACAGCAAGGAGATTACATTACCTTGGAACTGAAAAAAGCCAAGCTGGTCCTCAGT
TTAAACTTAGGAAGCAACCAGCTTGGCCCCATATATGGCCACACATCAGTGATGACAGGAAGTTTGCTGGATGACCACCACTGGCACTCT
GTGGTCATTGAGCGCCAGGGGCGGAGCATTAACCTCACTCTGGACAGGAGCATGCAGCACTTCCGTACCAATGGAGAGTTTGACTACCTG
GACTTGGACTATGAGATAACCTTTGGAGGCATCCCTTTCTCTGGCAAGCCCAGCTCCAGCAGTAGAAAGAATTTCAAAGGCTGCATGGAA
AGCATCAACTACAATGGCGTCAACATTACTGATCTTGCCAGAAGGAAGAAATTAGAGCCCTCAAATGTGGGAAATTTGAGCTTTTCTTGT
GTGGAACCCTATACGGTGCCTGTCTTTTTCAACGCTACAAGTTACCTGGAGGTGCCCGGACGGCTTAACCAGGACCTGTTCTCAGTCAGT
TTCCAGTTTAGGACATGGAACCCCAATGGTCTCCTGGTCTTCAGTCACTTTGCGGATAATTTGGGCAATGTGGAGATTGACCTCACTGAA
AGCAAAGTGGGTGTTCACATCAACATCACACAGACCAAGATGAGCCAAATCGATATTTCCTCAGGTTCTGGGTTGAATGATGGACAGTGG
CACGAGGTTCGCTTCCTAGCCAAGGAAAATTTTGCTATTCTCACCATCGATGGAGATGAAGCATCAGCAGTTCGAACTAATAGTCCCCTT
CAAGTTAAAACTGGCGAGAAGTACTTTTTTGGAGGTTTTCTGAACCAGATGAATAACTCAAGTCACTCTGTCCTTCAGCCTTCATTCCAA
GGATGCATGCAGCTCATTCAAGTGGACGATCAACTTGTAAATTTATACGAAGTGGCACAAAGGAAGCCGGGAAGTTTCGCGAATGTCAGC
ATTGACATGTGTGCGATCATAGACAGATGTGTGCCCAATCACTGTGAGCATGGTGGAAAGTGCTCGCAAACATGGGACAGCTTCAAATGC
ACTTGTGATGAGACAGGATACAGTGGGGCCACCTGCCACAACTCTATCTACGAGCCTTCCTGTGAAGCCTACAAACACCTAGGACAGACA
TCAAATTATTACTGGATAGATCCTGATGGCAGCGGACCTCTGGGGCCTCTGAAAGTTTACTGCAACATGACAGAGGACAAAGTGTGGACC
ATAGTGTCTCATGACTTGCAGATGCAGACGCCTGTGGTCGGCTACAACCCAGAAAAATACTCAGTGACACAGCTCGTTTACAGCGCCTCC
ATGGACCAGATAAGTGCCATCACTGACAGTGCCGAGTACTGCGAGCAGTATGTCTCCTATTTCTGCAAGATGTCAAGATTGTTGAACACC
CCAGGATTCGATACCAGCATCTTGCCAATTTGCAAGGACTCACTTGGCTGGATGTTTAACAGACTTGATACAAACTATGACCTGCTATTG
GACCAGTCAGAGCTCAGAAGCATTTACCTTGATAAGAATGAACAGTGTACCAAGGCATTCTTCAATTCTTGTGACACATACAAGGACAGT
TTAATATCTAATAATGAGTGGTGCTACTGCTTCCAGAGACAGCAAGACCCACCTTGCCAGACTGAGCTCAGCAATATTCAGAAGCGGCAA
GGGGTAAAGAAGCTCCTAGGACAGTATATCCCCCTGTGTGATGAAGATGGTTACTACAAGCCAACACAATGTCATGGCAGTGTTGGACAG
TGCTGGTGTGTTGACAGATATGGAAATGAAGTCATGGGATCCAGAATAAATGGTGTTGCAGATTGTGCTATAGATTTTGAGATCTCCGGA
GATTTTGCTAGTGGCGATTTTCATGAATGGACTGATGATGAGGATGATGAAGACGATATTATGAATGATGAAGATGAAATTGAAGATGAT
GATGAAGATGAAGGGGATGATGATGATGGTGGTGATGACCATGATGTATACATTTGATTGATGACAGTTGAAATCAATAAATTCTACATT
TCTAATATTTACAAAAATGATAGCCTATTTAAAATTATCTTCTTCCCCAATAACAAAATGATTCTAAACCTCACATATATTTTGTATAAT
TATTTGAAAAATTGCAGCTAAAGTTATAGAACTTTATGTTTAAATAAGAATCATTTGCTTTGAGTTTTTATATTCCTTACACAAAAAGAA
AATACATATGCAGTCTAGTCAGACAAAATAAAGTTTTGAAGTGCTACTATAATAAGTTTTTCACGAGAACAAACTTTGTAAATCTTCCAT
AAGCAAAATGACAGCTAGTGCTTGGGATCGTACATGTTAATTTTCTGAAAGATAATTCTAAGTGAAATTTAAAATAAATAAATTTTTAAT
GACCTGGGTCTTAAGGATTTAGGAAAAATATGCATGCTTTAATTGCATTTCCAAAGTAGCATCTTGCTAGACCTAGTTGAGTCAGGATAA
CAGAGAGATACCACATGGCAAGAAAAACAAAGTGACAATTGTAGAGTCCTCAATTGTGTTTACATTAATAGTGGTGTTTTTACCTATGAA
ATTATTCTGGATCTAATAGGACATTTTACAAAATGGCAAGTATGGAAAACCATGGATTCTGAAAGTTAAAAATTTAGTTGTTCTCCCCAA
TGTGTATTTTAATTTGGATGGCAGTCTCATGCAGATTTTTTAAAAGATTCTTTAATAACATGATTTGTTTGCCTTTCTAGATTTCTTTAT
CTTTCTGACCAGCAACTTAGGGAGCAGAATTTAAATTAGGAAGACAAAGGGAAAGATTCATTTAAACCATATTTTTACAAAGTTTGTCAT
TTGCCCCAAGGTCAAATTTTAAATTCTTAATTTTCATTTTATTTCCCATTTTAGGTAAAAGTTTGCATTTAATCTTAGAATTATGTTATT
TTTGTTAGTAGTGTGGAAACTTAGAGAACTTATTGTATGGTGCCTTGCAAAAATAGAGATAGAAAGATTTTAGCATGCATACCAATATAG
TATATTACGCAATATATAAGCACACCTAATTAACAGATTAATATCAGTAAAGGTATTGCTGCTGGAATGAAGAAAATGGGATACGTTTGT
TTCTTTTTTTCTATTGTTACATAATTGCCATGTGGACTTGTTTATGATTATTGTGTAGAGTAGCATTTAAGATTTAACTGTAGCAAAAAT
TACTTTAACCGCTGTATTTAAGTTAGCATGTTAATTAATTGTGTAGACATTTTGGCACACCATCACTTTTAACTATATCATACCAATGGT
TTTGTGCCCATAATAAAAATGGAAAAACCTGTTGAATGTTACGTATTGGTATCTTTAATTTCAACAGTGGGTAAACTGGTTTCCCAGTAT
ACAATTCATTGAAAGCAAAATTGATTAATTATTTCCATTTAATTTATACACACTCAATACAAAATTTAATGTTGACTTTACGTAATAAAG

>17917_17917_2_CNTNAP2-SPOCK3_CNTNAP2_chr7_147336399_ENST00000361727_SPOCK3_chr4_167675882_ENST00000357545_length(amino acids)=976AA_BP=779
MAHSARGNTRTEGERRLRLPCRSKPGRTGAWRGVRGEEEAGGAWLPRVFEDSPSPFKNPTESRTASPQRALGAPPAGRRRMQAAPRAGCG
AALLLWIVSSCLCRAWTAPSTSQKCDEPLVSGLPHVAFSSSSSISGSYSPGYAKINKRGGAGGWSPSDSDHYQWLQVDFGNRKQISAIAT
QGRYSSSDWVTQYRMLYSDTGRNWKPYHQDGNIWAFPGNINSDGVVRHELQHPIIARYVRIVPLDWNGEGRIGLRIEVYGCSYWADVINF
DGHVVLPYRFRNKKMKTLKDVIALNFKTSESEGVILHGEGQQGDYITLELKKAKLVLSLNLGSNQLGPIYGHTSVMTGSLLDDHHWHSVV
IERQGRSINLTLDRSMQHFRTNGEFDYLDLDYEITFGGIPFSGKPSSSSRKNFKGCMESINYNGVNITDLARRKKLEPSNVGNLSFSCVE
PYTVPVFFNATSYLEVPGRLNQDLFSVSFQFRTWNPNGLLVFSHFADNLGNVEIDLTESKVGVHINITQTKMSQIDISSGSGLNDGQWHE
VRFLAKENFAILTIDGDEASAVRTNSPLQVKTGEKYFFGGFLNQMNNSSHSVLQPSFQGCMQLIQVDDQLVNLYEVAQRKPGSFANVSID
MCAIIDRCVPNHCEHGGKCSQTWDSFKCTCDETGYSGATCHNSIYEPSCEAYKHLGQTSNYYWIDPDGSGPLGPLKVYCNMTEDKVWTIV
SHDLQMQTPVVGYNPEKYSVTQLVYSASMDQISAITDSAEYCEQYVSYFCKMSRLLNTPGFDTSILPICKDSLGWMFNRLDTNYDLLLDQ
SELRSIYLDKNEQCTKAFFNSCDTYKDSLISNNEWCYCFQRQQDPPCQTELSNIQKRQGVKKLLGQYIPLCDEDGYYKPTQCHGSVGQCW

--------------------------------------------------------------
>17917_17917_3_CNTNAP2-SPOCK3_CNTNAP2_chr7_147336399_ENST00000361727_SPOCK3_chr4_167675882_ENST00000504953_length(transcript)=4741nt_BP=2614nt
ACAAGCTCTCCATGTGAGCTGACAGGCGAGTGGAAACCCCTCGAGTCACGCTGCCCGGCGGCGGAGGGAGCGCTCGCCCGCAGTGGCAAC
AGCTGCACCACCGTCCCCGTCGCTCTGCCTTCCTCTTCTGCAGCCTCTGCTCTTCTGATTACCTCCCTCCCCCGTCCTTTGGTGATTTTT
TTTTTTCAAGAAGGAGAGGGCGGGGTAGGTGTCCGTTCCCTCCCCTCTTCCCCCTCCTTTGCCTTCTTGGTTTGAATTTCCTCCCCCGGC
GTTGCACTGGCACACAGTGCAAGAGGCAATACCCGCACGGAGGGAGAACGAAGGCTGAGACTCCCCTGCCGCTCCAAGCCCGGAAGAACT
GGAGCCTGGAGGGGGGTGAGGGGAGAAGAGGAAGCGGGAGGGGCTTGGCTTCCTCGCGTATTTGAGGACAGCCCATCTCCCTTCAAGAAC
CCTACGGAGAGTCGGACTGCATCTCCGCAGCGAGCTCTTGGAGCGCCGCCGGCCGGGAGGCGAAGGATGCAGGCGGCTCCGCGCGCCGGC
TGCGGGGCAGCGCTCCTGCTGTGGATTGTCAGCAGCTGCCTCTGCAGAGCCTGGACGGCTCCCTCCACGTCCCAAAAATGTGATGAGCCA
CTTGTCTCTGGACTCCCCCATGTGGCTTTCAGCAGCTCCTCCTCCATCTCTGGTAGCTATTCTCCCGGCTATGCCAAGATAAACAAGAGA
GGAGGTGCTGGGGGATGGTCTCCATCAGACAGCGACCATTATCAATGGCTTCAGGTTGACTTTGGCAATCGGAAGCAGATCAGTGCCATT
GCAACCCAAGGAAGGTATAGCAGCTCAGATTGGGTGACCCAATACCGGATGCTCTACAGCGACACAGGGAGAAACTGGAAACCCTATCAT
CAAGATGGGAATATCTGGGCATTTCCCGGAAACATTAACTCTGACGGTGTGGTCCGGCACGAATTACAGCATCCGATTATTGCCCGCTAT
GTGCGCATAGTGCCTCTGGATTGGAATGGAGAAGGTCGCATTGGACTCAGAATTGAAGTTTATGGCTGTTCTTACTGGGCTGATGTTATC
AACTTTGATGGCCATGTTGTATTACCATATAGATTCAGAAACAAGAAGATGAAAACACTGAAAGATGTCATTGCCTTGAACTTTAAGACG
TCTGAAAGTGAAGGAGTAATCCTGCACGGAGAAGGACAGCAAGGAGATTACATTACCTTGGAACTGAAAAAAGCCAAGCTGGTCCTCAGT
TTAAACTTAGGAAGCAACCAGCTTGGCCCCATATATGGCCACACATCAGTGATGACAGGAAGTTTGCTGGATGACCACCACTGGCACTCT
GTGGTCATTGAGCGCCAGGGGCGGAGCATTAACCTCACTCTGGACAGGAGCATGCAGCACTTCCGTACCAATGGAGAGTTTGACTACCTG
GACTTGGACTATGAGATAACCTTTGGAGGCATCCCTTTCTCTGGCAAGCCCAGCTCCAGCAGTAGAAAGAATTTCAAAGGCTGCATGGAA
AGCATCAACTACAATGGCGTCAACATTACTGATCTTGCCAGAAGGAAGAAATTAGAGCCCTCAAATGTGGGAAATTTGAGCTTTTCTTGT
GTGGAACCCTATACGGTGCCTGTCTTTTTCAACGCTACAAGTTACCTGGAGGTGCCCGGACGGCTTAACCAGGACCTGTTCTCAGTCAGT
TTCCAGTTTAGGACATGGAACCCCAATGGTCTCCTGGTCTTCAGTCACTTTGCGGATAATTTGGGCAATGTGGAGATTGACCTCACTGAA
AGCAAAGTGGGTGTTCACATCAACATCACACAGACCAAGATGAGCCAAATCGATATTTCCTCAGGTTCTGGGTTGAATGATGGACAGTGG
CACGAGGTTCGCTTCCTAGCCAAGGAAAATTTTGCTATTCTCACCATCGATGGAGATGAAGCATCAGCAGTTCGAACTAATAGTCCCCTT
CAAGTTAAAACTGGCGAGAAGTACTTTTTTGGAGGTTTTCTGAACCAGATGAATAACTCAAGTCACTCTGTCCTTCAGCCTTCATTCCAA
GGATGCATGCAGCTCATTCAAGTGGACGATCAACTTGTAAATTTATACGAAGTGGCACAAAGGAAGCCGGGAAGTTTCGCGAATGTCAGC
ATTGACATGTGTGCGATCATAGACAGATGTGTGCCCAATCACTGTGAGCATGGTGGAAAGTGCTCGCAAACATGGGACAGCTTCAAATGC
ACTTGTGATGAGACAGGATACAGTGGGGCCACCTGCCACAACTCTATCTACGAGCCTTCCTGTGAAGCCTACAAACACCTAGGACAGACA
TCAAATTATTACTGGATAGATCCTGATGGCAGCGGACCTCTGGGGCCTCTGAAAGTTTACTGCAACATGACAGAGGACAAAGTGTGGACC
ATAGTGTCTCATGACTTGCAGATGCAGACGCCTGTGGTCGGCTACAACCCAGAAAAATACTCAGTGACACAGCTCGTTTACAGCGCCTCC
ATGGACCAGATAAGTGCCATCACTGACAGTGCCGAGTACTGCGAGCAGTATGTCTCCTATTTCTGCAAGATGTCAAGATTGTTGAACACC
CCAGGATTCGATACCAGCATCTTGCCAATTTGCAAGGACTCACTTGGCTGGATGTTTAACAGACTTGATACAAACTATGACCTGCTATTG
GACCAGTCAGAGCTCAGAAGCATTTACCTTGATAAGAATGAACAGTGTACCAAGGCATTCTTCAATTCTTGTGACACATACAAGGACAGT
TTAATATCTAATAATGAGTGGTGCTACTGCTTCCAGAGACAGCAAGACCCACCTTGCCAGACTGAGCTCAGCAATATTCAGAAGCGGCAA
GGGGTAAAGAAGCTCCTAGGACAGTATATCCCCCTGTGTGATGAAGATGGTTACTACAAGCCAACACAATGTCATGGCAGTGTTGGACAG
TGCTGGTGTGTTGACAGATATGGAAATGAAGTCATGGGATCCAGAATAAATGGTGTTGCAGATTGTGCTATAGATTTTGAGATCTCCGGA
GATTTTGCTAGTGGCGATTTTCATGAATGGACTGATGATGAGGATGATGAAGACGATATTATGAATGATGAAGATGAAATTGAAGATGAT
GATGAAGATGAAGGGGATGATGATGATGGTGGTGATGACCATGATGTATACATTTGATTGATGACAGTTGAAATCAATAAATTCTACATT
TCTAATATTTACAAAAATGATAGCCTATTTAAAATTATCTTCTTCCCCAATAACAAAATGATTCTAAACCTCACATATATTTTGTATAAT
TATTTGAAAAATTGCAGCTAAAGTTATAGAACTTTATGTTTAAATAAGAATCATTTGCTTTGAGTTTTTATATTCCTTACACAAAAAGAA
AATACATATGCAGTCTAGTCAGACAAAATAAAGTTTTGAAGTGCTACTATAATAAGTTTTTCACGAGAACAAACTTTGTAAATCTTCCAT
AAGCAAAATGACAGCTAGTGCTTGGGATCGTACATGTTAATTTTCTGAAAGATAATTCTAAGTGAAATTTAAAATAAATAAATTTTTAAT
GACCTGGGTCTTAAGGATTTAGGAAAAATATGCATGCTTTAATTGCATTTCCAAAGTAGCATCTTGCTAGACCTAGTTGAGTCAGGATAA
CAGAGAGATACCACATGGCAAGAAAAACAAAGTGACAATTGTAGAGTCCTCAATTGTGTTTACATTAATAGTGGTGTTTTTACCTATGAA
ATTATTCTGGATCTAATAGGACATTTTACAAAATGGCAAGTATGGAAAACCATGGATTCTGAAAGTTAAAAATTTAGTTGTTCTCCCCAA
TGTGTATTTTAATTTGGATGGCAGTCTCATGCAGATTTTTTAAAAGATTCTTTAATAACATGATTTGTTTGCCTTTCTAGATTTCTTTAT
CTTTCTGACCAGCAACTTAGGGAGCAGAATTTAAATTAGGAAGACAAAGGGAAAGATTCATTTAAACCATATTTTTACAAAGTTTGTCAT
TTGCCCCAAGGTCAAATTTTAAATTCTTAATTTTCATTTTATTTCCCATTTTAGGTAAAAGTTTGCATTTAATCTTAGAATTATGTTATT
TTTGTTAGTAGTGTGGAAACTTAGAGAACTTATTGTATGGTGCCTTGCAAAAATAGAGATAGAAAGATTTTAGCATGCATACCAATATAG
TATATTACGCAATATATAAGCACACCTAATTAACAGATTAATATCAGTAAAGGTATTGCTGCTGGAATGAAGAAAATGGGATACGTTTGT
TTCTTTTTTTCTATTGTTACATAATTGCCATGTGGACTTGTTTATGATTATTGTGTAGAGTAGCATTTAAGATTTAACTGTAGCAAAAAT
TACTTTAACCGCTGTATTTAAGTTAGCATGTTAATTAATTGTGTAGACATTTTGGCACACCATCACTTTTAACTATATCATACCAATGGT
TTTGTGCCCATAATAAAAATGGAAAAACCTGTTGAATGTTACGTATTGGTATCTTTAATTTCAACAGTGGGTAAACTGGTTTCCCAGTAT
ACAATTCATTGAAAGCAAAATTGATTAATTATTTCCATTTAATTTATACACACTCAATACAAAATTTAATGTTGACTTTACGTAATAAAG

>17917_17917_3_CNTNAP2-SPOCK3_CNTNAP2_chr7_147336399_ENST00000361727_SPOCK3_chr4_167675882_ENST00000504953_length(amino acids)=976AA_BP=779
MAHSARGNTRTEGERRLRLPCRSKPGRTGAWRGVRGEEEAGGAWLPRVFEDSPSPFKNPTESRTASPQRALGAPPAGRRRMQAAPRAGCG
AALLLWIVSSCLCRAWTAPSTSQKCDEPLVSGLPHVAFSSSSSISGSYSPGYAKINKRGGAGGWSPSDSDHYQWLQVDFGNRKQISAIAT
QGRYSSSDWVTQYRMLYSDTGRNWKPYHQDGNIWAFPGNINSDGVVRHELQHPIIARYVRIVPLDWNGEGRIGLRIEVYGCSYWADVINF
DGHVVLPYRFRNKKMKTLKDVIALNFKTSESEGVILHGEGQQGDYITLELKKAKLVLSLNLGSNQLGPIYGHTSVMTGSLLDDHHWHSVV
IERQGRSINLTLDRSMQHFRTNGEFDYLDLDYEITFGGIPFSGKPSSSSRKNFKGCMESINYNGVNITDLARRKKLEPSNVGNLSFSCVE
PYTVPVFFNATSYLEVPGRLNQDLFSVSFQFRTWNPNGLLVFSHFADNLGNVEIDLTESKVGVHINITQTKMSQIDISSGSGLNDGQWHE
VRFLAKENFAILTIDGDEASAVRTNSPLQVKTGEKYFFGGFLNQMNNSSHSVLQPSFQGCMQLIQVDDQLVNLYEVAQRKPGSFANVSID
MCAIIDRCVPNHCEHGGKCSQTWDSFKCTCDETGYSGATCHNSIYEPSCEAYKHLGQTSNYYWIDPDGSGPLGPLKVYCNMTEDKVWTIV
SHDLQMQTPVVGYNPEKYSVTQLVYSASMDQISAITDSAEYCEQYVSYFCKMSRLLNTPGFDTSILPICKDSLGWMFNRLDTNYDLLLDQ
SELRSIYLDKNEQCTKAFFNSCDTYKDSLISNNEWCYCFQRQQDPPCQTELSNIQKRQGVKKLLGQYIPLCDEDGYYKPTQCHGSVGQCW

--------------------------------------------------------------
>17917_17917_4_CNTNAP2-SPOCK3_CNTNAP2_chr7_147336399_ENST00000361727_SPOCK3_chr4_167675882_ENST00000506886_length(transcript)=4740nt_BP=2614nt
ACAAGCTCTCCATGTGAGCTGACAGGCGAGTGGAAACCCCTCGAGTCACGCTGCCCGGCGGCGGAGGGAGCGCTCGCCCGCAGTGGCAAC
AGCTGCACCACCGTCCCCGTCGCTCTGCCTTCCTCTTCTGCAGCCTCTGCTCTTCTGATTACCTCCCTCCCCCGTCCTTTGGTGATTTTT
TTTTTTCAAGAAGGAGAGGGCGGGGTAGGTGTCCGTTCCCTCCCCTCTTCCCCCTCCTTTGCCTTCTTGGTTTGAATTTCCTCCCCCGGC
GTTGCACTGGCACACAGTGCAAGAGGCAATACCCGCACGGAGGGAGAACGAAGGCTGAGACTCCCCTGCCGCTCCAAGCCCGGAAGAACT
GGAGCCTGGAGGGGGGTGAGGGGAGAAGAGGAAGCGGGAGGGGCTTGGCTTCCTCGCGTATTTGAGGACAGCCCATCTCCCTTCAAGAAC
CCTACGGAGAGTCGGACTGCATCTCCGCAGCGAGCTCTTGGAGCGCCGCCGGCCGGGAGGCGAAGGATGCAGGCGGCTCCGCGCGCCGGC
TGCGGGGCAGCGCTCCTGCTGTGGATTGTCAGCAGCTGCCTCTGCAGAGCCTGGACGGCTCCCTCCACGTCCCAAAAATGTGATGAGCCA
CTTGTCTCTGGACTCCCCCATGTGGCTTTCAGCAGCTCCTCCTCCATCTCTGGTAGCTATTCTCCCGGCTATGCCAAGATAAACAAGAGA
GGAGGTGCTGGGGGATGGTCTCCATCAGACAGCGACCATTATCAATGGCTTCAGGTTGACTTTGGCAATCGGAAGCAGATCAGTGCCATT
GCAACCCAAGGAAGGTATAGCAGCTCAGATTGGGTGACCCAATACCGGATGCTCTACAGCGACACAGGGAGAAACTGGAAACCCTATCAT
CAAGATGGGAATATCTGGGCATTTCCCGGAAACATTAACTCTGACGGTGTGGTCCGGCACGAATTACAGCATCCGATTATTGCCCGCTAT
GTGCGCATAGTGCCTCTGGATTGGAATGGAGAAGGTCGCATTGGACTCAGAATTGAAGTTTATGGCTGTTCTTACTGGGCTGATGTTATC
AACTTTGATGGCCATGTTGTATTACCATATAGATTCAGAAACAAGAAGATGAAAACACTGAAAGATGTCATTGCCTTGAACTTTAAGACG
TCTGAAAGTGAAGGAGTAATCCTGCACGGAGAAGGACAGCAAGGAGATTACATTACCTTGGAACTGAAAAAAGCCAAGCTGGTCCTCAGT
TTAAACTTAGGAAGCAACCAGCTTGGCCCCATATATGGCCACACATCAGTGATGACAGGAAGTTTGCTGGATGACCACCACTGGCACTCT
GTGGTCATTGAGCGCCAGGGGCGGAGCATTAACCTCACTCTGGACAGGAGCATGCAGCACTTCCGTACCAATGGAGAGTTTGACTACCTG
GACTTGGACTATGAGATAACCTTTGGAGGCATCCCTTTCTCTGGCAAGCCCAGCTCCAGCAGTAGAAAGAATTTCAAAGGCTGCATGGAA
AGCATCAACTACAATGGCGTCAACATTACTGATCTTGCCAGAAGGAAGAAATTAGAGCCCTCAAATGTGGGAAATTTGAGCTTTTCTTGT
GTGGAACCCTATACGGTGCCTGTCTTTTTCAACGCTACAAGTTACCTGGAGGTGCCCGGACGGCTTAACCAGGACCTGTTCTCAGTCAGT
TTCCAGTTTAGGACATGGAACCCCAATGGTCTCCTGGTCTTCAGTCACTTTGCGGATAATTTGGGCAATGTGGAGATTGACCTCACTGAA
AGCAAAGTGGGTGTTCACATCAACATCACACAGACCAAGATGAGCCAAATCGATATTTCCTCAGGTTCTGGGTTGAATGATGGACAGTGG
CACGAGGTTCGCTTCCTAGCCAAGGAAAATTTTGCTATTCTCACCATCGATGGAGATGAAGCATCAGCAGTTCGAACTAATAGTCCCCTT
CAAGTTAAAACTGGCGAGAAGTACTTTTTTGGAGGTTTTCTGAACCAGATGAATAACTCAAGTCACTCTGTCCTTCAGCCTTCATTCCAA
GGATGCATGCAGCTCATTCAAGTGGACGATCAACTTGTAAATTTATACGAAGTGGCACAAAGGAAGCCGGGAAGTTTCGCGAATGTCAGC
ATTGACATGTGTGCGATCATAGACAGATGTGTGCCCAATCACTGTGAGCATGGTGGAAAGTGCTCGCAAACATGGGACAGCTTCAAATGC
ACTTGTGATGAGACAGGATACAGTGGGGCCACCTGCCACAACTCTATCTACGAGCCTTCCTGTGAAGCCTACAAACACCTAGGACAGACA
TCAAATTATTACTGGATAGATCCTGATGGCAGCGGACCTCTGGGGCCTCTGAAAGTTTACTGCAACATGACAGAGGACAAAGTGTGGACC
ATAGTGTCTCATGACTTGCAGATGCAGACGCCTGTGGTCGGCTACAACCCAGAAAAATACTCAGTGACACAGCTCGTTTACAGCGCCTCC
ATGGACCAGATAAGTGCCATCACTGACAGTGCCGAGTACTGCGAGCAGTATGTCTCCTATTTCTGCAAGATGTCAAGATTGTTGAACACC
CCAGGATTCGATACCAGCATCTTGCCAATTTGCAAGGACTCACTTGGCTGGATGTTTAACAGACTTGATACAAACTATGACCTGCTATTG
GACCAGTCAGAGCTCAGAAGCATTTACCTTGATAAGAATGAACAGTGTACCAAGGCATTCTTCAATTCTTGTGACACATACAAGGACAGT
TTAATATCTAATAATGAGTGGTGCTACTGCTTCCAGAGACAGCAAGACCCACCTTGCCAGACTGAGCTCAGCAATATTCAGAAGCGGCAA
GGGGTAAAGAAGCTCCTAGGACAGTATATCCCCCTGTGTGATGAAGATGGTTACTACAAGCCAACACAATGTCATGGCAGTGTTGGACAG
TGCTGGTGTGTTGACAGATATGGAAATGAAGTCATGGGATCCAGAATAAATGGTGTTGCAGATTGTGCTATAGATTTTGAGATCTCCGGA
GATTTTGCTAGTGGCGATTTTCATGAATGGACTGATGATGAGGATGATGAAGACGATATTATGAATGATGAAGATGAAATTGAAGATGAT
GATGAAGATGAAGGGGATGATGATGATGGTGGTGATGACCATGATGTATACATTTGATTGATGACAGTTGAAATCAATAAATTCTACATT
TCTAATATTTACAAAAATGATAGCCTATTTAAAATTATCTTCTTCCCCAATAACAAAATGATTCTAAACCTCACATATATTTTGTATAAT
TATTTGAAAAATTGCAGCTAAAGTTATAGAACTTTATGTTTAAATAAGAATCATTTGCTTTGAGTTTTTATATTCCTTACACAAAAAGAA
AATACATATGCAGTCTAGTCAGACAAAATAAAGTTTTGAAGTGCTACTATAATAAGTTTTTCACGAGAACAAACTTTGTAAATCTTCCAT
AAGCAAAATGACAGCTAGTGCTTGGGATCGTACATGTTAATTTTCTGAAAGATAATTCTAAGTGAAATTTAAAATAAATAAATTTTTAAT
GACCTGGGTCTTAAGGATTTAGGAAAAATATGCATGCTTTAATTGCATTTCCAAAGTAGCATCTTGCTAGACCTAGTTGAGTCAGGATAA
CAGAGAGATACCACATGGCAAGAAAAACAAAGTGACAATTGTAGAGTCCTCAATTGTGTTTACATTAATAGTGGTGTTTTTACCTATGAA
ATTATTCTGGATCTAATAGGACATTTTACAAAATGGCAAGTATGGAAAACCATGGATTCTGAAAGTTAAAAATTTAGTTGTTCTCCCCAA
TGTGTATTTTAATTTGGATGGCAGTCTCATGCAGATTTTTTAAAAGATTCTTTAATAACATGATTTGTTTGCCTTTCTAGATTTCTTTAT
CTTTCTGACCAGCAACTTAGGGAGCAGAATTTAAATTAGGAAGACAAAGGGAAAGATTCATTTAAACCATATTTTTACAAAGTTTGTCAT
TTGCCCCAAGGTCAAATTTTAAATTCTTAATTTTCATTTTATTTCCCATTTTAGGTAAAAGTTTGCATTTAATCTTAGAATTATGTTATT
TTTGTTAGTAGTGTGGAAACTTAGAGAACTTATTGTATGGTGCCTTGCAAAAATAGAGATAGAAAGATTTTAGCATGCATACCAATATAG
TATATTACGCAATATATAAGCACACCTAATTAACAGATTAATATCAGTAAAGGTATTGCTGCTGGAATGAAGAAAATGGGATACGTTTGT
TTCTTTTTTTCTATTGTTACATAATTGCCATGTGGACTTGTTTATGATTATTGTGTAGAGTAGCATTTAAGATTTAACTGTAGCAAAAAT
TACTTTAACCGCTGTATTTAAGTTAGCATGTTAATTAATTGTGTAGACATTTTGGCACACCATCACTTTTAACTATATCATACCAATGGT
TTTGTGCCCATAATAAAAATGGAAAAACCTGTTGAATGTTACGTATTGGTATCTTTAATTTCAACAGTGGGTAAACTGGTTTCCCAGTAT
ACAATTCATTGAAAGCAAAATTGATTAATTATTTCCATTTAATTTATACACACTCAATACAAAATTTAATGTTGACTTTACGTAATAAAG

>17917_17917_4_CNTNAP2-SPOCK3_CNTNAP2_chr7_147336399_ENST00000361727_SPOCK3_chr4_167675882_ENST00000506886_length(amino acids)=976AA_BP=779
MAHSARGNTRTEGERRLRLPCRSKPGRTGAWRGVRGEEEAGGAWLPRVFEDSPSPFKNPTESRTASPQRALGAPPAGRRRMQAAPRAGCG
AALLLWIVSSCLCRAWTAPSTSQKCDEPLVSGLPHVAFSSSSSISGSYSPGYAKINKRGGAGGWSPSDSDHYQWLQVDFGNRKQISAIAT
QGRYSSSDWVTQYRMLYSDTGRNWKPYHQDGNIWAFPGNINSDGVVRHELQHPIIARYVRIVPLDWNGEGRIGLRIEVYGCSYWADVINF
DGHVVLPYRFRNKKMKTLKDVIALNFKTSESEGVILHGEGQQGDYITLELKKAKLVLSLNLGSNQLGPIYGHTSVMTGSLLDDHHWHSVV
IERQGRSINLTLDRSMQHFRTNGEFDYLDLDYEITFGGIPFSGKPSSSSRKNFKGCMESINYNGVNITDLARRKKLEPSNVGNLSFSCVE
PYTVPVFFNATSYLEVPGRLNQDLFSVSFQFRTWNPNGLLVFSHFADNLGNVEIDLTESKVGVHINITQTKMSQIDISSGSGLNDGQWHE
VRFLAKENFAILTIDGDEASAVRTNSPLQVKTGEKYFFGGFLNQMNNSSHSVLQPSFQGCMQLIQVDDQLVNLYEVAQRKPGSFANVSID
MCAIIDRCVPNHCEHGGKCSQTWDSFKCTCDETGYSGATCHNSIYEPSCEAYKHLGQTSNYYWIDPDGSGPLGPLKVYCNMTEDKVWTIV
SHDLQMQTPVVGYNPEKYSVTQLVYSASMDQISAITDSAEYCEQYVSYFCKMSRLLNTPGFDTSILPICKDSLGWMFNRLDTNYDLLLDQ
SELRSIYLDKNEQCTKAFFNSCDTYKDSLISNNEWCYCFQRQQDPPCQTELSNIQKRQGVKKLLGQYIPLCDEDGYYKPTQCHGSVGQCW

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>17917_17917_5_CNTNAP2-SPOCK3_CNTNAP2_chr7_147336399_ENST00000361727_SPOCK3_chr4_167675882_ENST00000511531_length(transcript)=4740nt_BP=2614nt
ACAAGCTCTCCATGTGAGCTGACAGGCGAGTGGAAACCCCTCGAGTCACGCTGCCCGGCGGCGGAGGGAGCGCTCGCCCGCAGTGGCAAC
AGCTGCACCACCGTCCCCGTCGCTCTGCCTTCCTCTTCTGCAGCCTCTGCTCTTCTGATTACCTCCCTCCCCCGTCCTTTGGTGATTTTT
TTTTTTCAAGAAGGAGAGGGCGGGGTAGGTGTCCGTTCCCTCCCCTCTTCCCCCTCCTTTGCCTTCTTGGTTTGAATTTCCTCCCCCGGC
GTTGCACTGGCACACAGTGCAAGAGGCAATACCCGCACGGAGGGAGAACGAAGGCTGAGACTCCCCTGCCGCTCCAAGCCCGGAAGAACT
GGAGCCTGGAGGGGGGTGAGGGGAGAAGAGGAAGCGGGAGGGGCTTGGCTTCCTCGCGTATTTGAGGACAGCCCATCTCCCTTCAAGAAC
CCTACGGAGAGTCGGACTGCATCTCCGCAGCGAGCTCTTGGAGCGCCGCCGGCCGGGAGGCGAAGGATGCAGGCGGCTCCGCGCGCCGGC
TGCGGGGCAGCGCTCCTGCTGTGGATTGTCAGCAGCTGCCTCTGCAGAGCCTGGACGGCTCCCTCCACGTCCCAAAAATGTGATGAGCCA
CTTGTCTCTGGACTCCCCCATGTGGCTTTCAGCAGCTCCTCCTCCATCTCTGGTAGCTATTCTCCCGGCTATGCCAAGATAAACAAGAGA
GGAGGTGCTGGGGGATGGTCTCCATCAGACAGCGACCATTATCAATGGCTTCAGGTTGACTTTGGCAATCGGAAGCAGATCAGTGCCATT
GCAACCCAAGGAAGGTATAGCAGCTCAGATTGGGTGACCCAATACCGGATGCTCTACAGCGACACAGGGAGAAACTGGAAACCCTATCAT
CAAGATGGGAATATCTGGGCATTTCCCGGAAACATTAACTCTGACGGTGTGGTCCGGCACGAATTACAGCATCCGATTATTGCCCGCTAT
GTGCGCATAGTGCCTCTGGATTGGAATGGAGAAGGTCGCATTGGACTCAGAATTGAAGTTTATGGCTGTTCTTACTGGGCTGATGTTATC
AACTTTGATGGCCATGTTGTATTACCATATAGATTCAGAAACAAGAAGATGAAAACACTGAAAGATGTCATTGCCTTGAACTTTAAGACG
TCTGAAAGTGAAGGAGTAATCCTGCACGGAGAAGGACAGCAAGGAGATTACATTACCTTGGAACTGAAAAAAGCCAAGCTGGTCCTCAGT
TTAAACTTAGGAAGCAACCAGCTTGGCCCCATATATGGCCACACATCAGTGATGACAGGAAGTTTGCTGGATGACCACCACTGGCACTCT
GTGGTCATTGAGCGCCAGGGGCGGAGCATTAACCTCACTCTGGACAGGAGCATGCAGCACTTCCGTACCAATGGAGAGTTTGACTACCTG
GACTTGGACTATGAGATAACCTTTGGAGGCATCCCTTTCTCTGGCAAGCCCAGCTCCAGCAGTAGAAAGAATTTCAAAGGCTGCATGGAA
AGCATCAACTACAATGGCGTCAACATTACTGATCTTGCCAGAAGGAAGAAATTAGAGCCCTCAAATGTGGGAAATTTGAGCTTTTCTTGT
GTGGAACCCTATACGGTGCCTGTCTTTTTCAACGCTACAAGTTACCTGGAGGTGCCCGGACGGCTTAACCAGGACCTGTTCTCAGTCAGT
TTCCAGTTTAGGACATGGAACCCCAATGGTCTCCTGGTCTTCAGTCACTTTGCGGATAATTTGGGCAATGTGGAGATTGACCTCACTGAA
AGCAAAGTGGGTGTTCACATCAACATCACACAGACCAAGATGAGCCAAATCGATATTTCCTCAGGTTCTGGGTTGAATGATGGACAGTGG
CACGAGGTTCGCTTCCTAGCCAAGGAAAATTTTGCTATTCTCACCATCGATGGAGATGAAGCATCAGCAGTTCGAACTAATAGTCCCCTT
CAAGTTAAAACTGGCGAGAAGTACTTTTTTGGAGGTTTTCTGAACCAGATGAATAACTCAAGTCACTCTGTCCTTCAGCCTTCATTCCAA
GGATGCATGCAGCTCATTCAAGTGGACGATCAACTTGTAAATTTATACGAAGTGGCACAAAGGAAGCCGGGAAGTTTCGCGAATGTCAGC
ATTGACATGTGTGCGATCATAGACAGATGTGTGCCCAATCACTGTGAGCATGGTGGAAAGTGCTCGCAAACATGGGACAGCTTCAAATGC
ACTTGTGATGAGACAGGATACAGTGGGGCCACCTGCCACAACTCTATCTACGAGCCTTCCTGTGAAGCCTACAAACACCTAGGACAGACA
TCAAATTATTACTGGATAGATCCTGATGGCAGCGGACCTCTGGGGCCTCTGAAAGTTTACTGCAACATGACAGAGGACAAAGTGTGGACC
ATAGTGTCTCATGACTTGCAGATGCAGACGCCTGTGGTCGGCTACAACCCAGAAAAATACTCAGTGACACAGCTCGTTTACAGCGCCTCC
ATGGACCAGATAAGTGCCATCACTGACAGTGCCGAGTACTGCGAGCAGTATGTCTCCTATTTCTGCAAGATGTCAAGATTGTTGAACACC
CCAGGATTCGATACCAGCATCTTGCCAATTTGCAAGGACTCACTTGGCTGGATGTTTAACAGACTTGATACAAACTATGACCTGCTATTG
GACCAGTCAGAGCTCAGAAGCATTTACCTTGATAAGAATGAACAGTGTACCAAGGCATTCTTCAATTCTTGTGACACATACAAGGACAGT
TTAATATCTAATAATGAGTGGTGCTACTGCTTCCAGAGACAGCAAGACCCACCTTGCCAGACTGAGCTCAGCAATATTCAGAAGCGGCAA
GGGGTAAAGAAGCTCCTAGGACAGTATATCCCCCTGTGTGATGAAGATGGTTACTACAAGCCAACACAATGTCATGGCAGTGTTGGACAG
TGCTGGTGTGTTGACAGATATGGAAATGAAGTCATGGGATCCAGAATAAATGGTGTTGCAGATTGTGCTATAGATTTTGAGATCTCCGGA
GATTTTGCTAGTGGCGATTTTCATGAATGGACTGATGATGAGGATGATGAAGACGATATTATGAATGATGAAGATGAAATTGAAGATGAT
GATGAAGATGAAGGGGATGATGATGATGGTGGTGATGACCATGATGTATACATTTGATTGATGACAGTTGAAATCAATAAATTCTACATT
TCTAATATTTACAAAAATGATAGCCTATTTAAAATTATCTTCTTCCCCAATAACAAAATGATTCTAAACCTCACATATATTTTGTATAAT
TATTTGAAAAATTGCAGCTAAAGTTATAGAACTTTATGTTTAAATAAGAATCATTTGCTTTGAGTTTTTATATTCCTTACACAAAAAGAA
AATACATATGCAGTCTAGTCAGACAAAATAAAGTTTTGAAGTGCTACTATAATAAGTTTTTCACGAGAACAAACTTTGTAAATCTTCCAT
AAGCAAAATGACAGCTAGTGCTTGGGATCGTACATGTTAATTTTCTGAAAGATAATTCTAAGTGAAATTTAAAATAAATAAATTTTTAAT
GACCTGGGTCTTAAGGATTTAGGAAAAATATGCATGCTTTAATTGCATTTCCAAAGTAGCATCTTGCTAGACCTAGTTGAGTCAGGATAA
CAGAGAGATACCACATGGCAAGAAAAACAAAGTGACAATTGTAGAGTCCTCAATTGTGTTTACATTAATAGTGGTGTTTTTACCTATGAA
ATTATTCTGGATCTAATAGGACATTTTACAAAATGGCAAGTATGGAAAACCATGGATTCTGAAAGTTAAAAATTTAGTTGTTCTCCCCAA
TGTGTATTTTAATTTGGATGGCAGTCTCATGCAGATTTTTTAAAAGATTCTTTAATAACATGATTTGTTTGCCTTTCTAGATTTCTTTAT
CTTTCTGACCAGCAACTTAGGGAGCAGAATTTAAATTAGGAAGACAAAGGGAAAGATTCATTTAAACCATATTTTTACAAAGTTTGTCAT
TTGCCCCAAGGTCAAATTTTAAATTCTTAATTTTCATTTTATTTCCCATTTTAGGTAAAAGTTTGCATTTAATCTTAGAATTATGTTATT
TTTGTTAGTAGTGTGGAAACTTAGAGAACTTATTGTATGGTGCCTTGCAAAAATAGAGATAGAAAGATTTTAGCATGCATACCAATATAG
TATATTACGCAATATATAAGCACACCTAATTAACAGATTAATATCAGTAAAGGTATTGCTGCTGGAATGAAGAAAATGGGATACGTTTGT
TTCTTTTTTTCTATTGTTACATAATTGCCATGTGGACTTGTTTATGATTATTGTGTAGAGTAGCATTTAAGATTTAACTGTAGCAAAAAT
TACTTTAACCGCTGTATTTAAGTTAGCATGTTAATTAATTGTGTAGACATTTTGGCACACCATCACTTTTAACTATATCATACCAATGGT
TTTGTGCCCATAATAAAAATGGAAAAACCTGTTGAATGTTACGTATTGGTATCTTTAATTTCAACAGTGGGTAAACTGGTTTCCCAGTAT
ACAATTCATTGAAAGCAAAATTGATTAATTATTTCCATTTAATTTATACACACTCAATACAAAATTTAATGTTGACTTTACGTAATAAAG

>17917_17917_5_CNTNAP2-SPOCK3_CNTNAP2_chr7_147336399_ENST00000361727_SPOCK3_chr4_167675882_ENST00000511531_length(amino acids)=976AA_BP=779
MAHSARGNTRTEGERRLRLPCRSKPGRTGAWRGVRGEEEAGGAWLPRVFEDSPSPFKNPTESRTASPQRALGAPPAGRRRMQAAPRAGCG
AALLLWIVSSCLCRAWTAPSTSQKCDEPLVSGLPHVAFSSSSSISGSYSPGYAKINKRGGAGGWSPSDSDHYQWLQVDFGNRKQISAIAT
QGRYSSSDWVTQYRMLYSDTGRNWKPYHQDGNIWAFPGNINSDGVVRHELQHPIIARYVRIVPLDWNGEGRIGLRIEVYGCSYWADVINF
DGHVVLPYRFRNKKMKTLKDVIALNFKTSESEGVILHGEGQQGDYITLELKKAKLVLSLNLGSNQLGPIYGHTSVMTGSLLDDHHWHSVV
IERQGRSINLTLDRSMQHFRTNGEFDYLDLDYEITFGGIPFSGKPSSSSRKNFKGCMESINYNGVNITDLARRKKLEPSNVGNLSFSCVE
PYTVPVFFNATSYLEVPGRLNQDLFSVSFQFRTWNPNGLLVFSHFADNLGNVEIDLTESKVGVHINITQTKMSQIDISSGSGLNDGQWHE
VRFLAKENFAILTIDGDEASAVRTNSPLQVKTGEKYFFGGFLNQMNNSSHSVLQPSFQGCMQLIQVDDQLVNLYEVAQRKPGSFANVSID
MCAIIDRCVPNHCEHGGKCSQTWDSFKCTCDETGYSGATCHNSIYEPSCEAYKHLGQTSNYYWIDPDGSGPLGPLKVYCNMTEDKVWTIV
SHDLQMQTPVVGYNPEKYSVTQLVYSASMDQISAITDSAEYCEQYVSYFCKMSRLLNTPGFDTSILPICKDSLGWMFNRLDTNYDLLLDQ
SELRSIYLDKNEQCTKAFFNSCDTYKDSLISNNEWCYCFQRQQDPPCQTELSNIQKRQGVKKLLGQYIPLCDEDGYYKPTQCHGSVGQCW

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Top

Fusion Gene PPI Analysis for CNTNAP2-SPOCK3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for CNTNAP2-SPOCK3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for CNTNAP2-SPOCK3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneCNTNAP2C0004352Autistic Disorder4CTD_human
HgeneCNTNAP2C1510586Autism Spectrum Disorders4CTD_human
HgeneCNTNAP2C0023012Language Delay3CTD_human
HgeneCNTNAP2C0023014Language Development Disorders3CTD_human
HgeneCNTNAP2C0241210Speech Delay3CTD_human
HgeneCNTNAP2C0454655Semantic-Pragmatic Disorder3CTD_human
HgeneCNTNAP2C0751257Auditory Processing Disorder, Central3CTD_human
HgeneCNTNAP2C0014544Epilepsy2CTD_human
HgeneCNTNAP2C0086237Epilepsy, Cryptogenic2CTD_human
HgeneCNTNAP2C0236018Aura2CTD_human
HgeneCNTNAP2C0751111Awakening Epilepsy2CTD_human
HgeneCNTNAP2C2750246Pitt-Hopkins-Like Syndrome 12CTD_human;GENOMICS_ENGLAND;ORPHANET
HgeneCNTNAP2C0001973Alcoholic Intoxication, Chronic1PSYGENET
HgeneCNTNAP2C0005586Bipolar Disorder1PSYGENET
HgeneCNTNAP2C0030567Parkinson Disease1CTD_human
HgeneCNTNAP2C0036341Schizophrenia1CTD_human
HgeneCNTNAP2C0038131Stammering1CTD_human
HgeneCNTNAP2C0038506Stuttering1CTD_human
HgeneCNTNAP2C0041696Unipolar Depression1PSYGENET
HgeneCNTNAP2C0149925Small cell carcinoma of lung1CTD_human
HgeneCNTNAP2C0454542Stuttering, Acquired1CTD_human
HgeneCNTNAP2C0751217Hyperkinesia, Generalized1CTD_human
HgeneCNTNAP2C0751527Stuttering, Adult1CTD_human
HgeneCNTNAP2C0751528Stuttering, Childhood1CTD_human
HgeneCNTNAP2C0751529Stuttering, Developmental1CTD_human
HgeneCNTNAP2C1269683Major Depressive Disorder1PSYGENET
HgeneCNTNAP2C1970431PITT-HOPKINS SYNDROME1CTD_human
HgeneCNTNAP2C3489627Stuttering, Familial Persistent 11CTD_human
HgeneCNTNAP2C3887506Hyperkinesia1CTD_human
HgeneCNTNAP2C4552043Cortical dysplasia with focal epilepsy syndrome1CTD_human;GENOMICS_ENGLAND;ORPHANET