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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:KIF26A-C14orf2 (FusionGDB2 ID:HG26153TG9556)

Fusion Gene Summary for KIF26A-C14orf2

check button Fusion gene summary
Fusion gene informationFusion gene name: KIF26A-C14orf2
Fusion gene ID: hg26153tg9556
HgeneTgene
Gene symbol

KIF26A

C14orf2

Gene ID

26153

9556

Gene namekinesin family member 26AATP synthase membrane subunit 6.8PL
Synonyms-6.8PL|C14orf2|MLQ|MP68|PLPM
Cytomap('KIF26A')('C14orf2')

14q32.33

14q32.33

Type of geneprotein-codingprotein-coding
Descriptionkinesin-like protein KIF26AKIF26A variant proteinATP synthase subunit ATP5MPL, mitochondrial6.8 kDa mitochondrial proteolipid6.8 kDa mitochondrial proteolipid protein6.8-kDa proteolipid with N-terminal sequence Met-Leu-Gln (MLQ)
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000423312, ENST00000315264, 
Fusion gene scores* DoF score4 X 2 X 4=323 X 2 X 2=12
# samples 44
** MAII scorelog2(4/32*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(4/12*10)=1.73696559416621
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: KIF26A [Title/Abstract] AND C14orf2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointKIF26A(104605625)-C14orf2(104379031), # samples:3
Anticipated loss of major functional domain due to fusion event.KIF26A-C14orf2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
KIF26A-C14orf2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
KIF26A-C14orf2 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
KIF26A-C14orf2 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across KIF26A (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across C14orf2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-RD-A8N9-01AKIF26Achr14

104605625

-C14orf2chr14

104379031

-
ChimerDB4STADTCGA-RD-A8N9-01AKIF26Achr14

104605625

+C14orf2chr14

104379031

-


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Fusion Gene ORF analysis for KIF26A-C14orf2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000423312ENST00000414262KIF26Achr14

104605625

+C14orf2chr14

104379031

-
5CDS-3UTRENST00000423312ENST00000553430KIF26Achr14

104605625

+C14orf2chr14

104379031

-
5CDS-3UTRENST00000423312ENST00000555030KIF26Achr14

104605625

+C14orf2chr14

104379031

-
5CDS-3UTRENST00000423312ENST00000557040KIF26Achr14

104605625

+C14orf2chr14

104379031

-
5CDS-5UTRENST00000423312ENST00000553449KIF26Achr14

104605625

+C14orf2chr14

104379031

-
5CDS-intronENST00000423312ENST00000554713KIF26Achr14

104605625

+C14orf2chr14

104379031

-
5UTR-3CDSENST00000315264ENST00000286953KIF26Achr14

104605625

+C14orf2chr14

104379031

-
5UTR-3CDSENST00000315264ENST00000554880KIF26Achr14

104605625

+C14orf2chr14

104379031

-
5UTR-3UTRENST00000315264ENST00000414262KIF26Achr14

104605625

+C14orf2chr14

104379031

-
5UTR-3UTRENST00000315264ENST00000553430KIF26Achr14

104605625

+C14orf2chr14

104379031

-
5UTR-3UTRENST00000315264ENST00000555030KIF26Achr14

104605625

+C14orf2chr14

104379031

-
5UTR-3UTRENST00000315264ENST00000557040KIF26Achr14

104605625

+C14orf2chr14

104379031

-
5UTR-5UTRENST00000315264ENST00000553449KIF26Achr14

104605625

+C14orf2chr14

104379031

-
5UTR-intronENST00000315264ENST00000554713KIF26Achr14

104605625

+C14orf2chr14

104379031

-
Frame-shiftENST00000423312ENST00000554880KIF26Achr14

104605625

+C14orf2chr14

104379031

-
In-frameENST00000423312ENST00000286953KIF26Achr14

104605625

+C14orf2chr14

104379031

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000423312KIF26Achr14104605625+ENST00000286953C14orf2chr14104379031-69528828444138

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000423312ENST00000286953KIF26Achr14104605625+C14orf2chr14104379031-0.429041240.57095873

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Fusion Genomic Features for KIF26A-C14orf2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for KIF26A-C14orf2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr14:104605625/chr14:104379031)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneC14orf2chr14:104605625chr14:104379031ENST000005534300320_38078.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneKIF26Achr14:104605625chr14:104379031ENST00000423312+2151784_1812961883.0Coiled coilOntology_term=ECO:0000255
HgeneKIF26Achr14:104605625chr14:104379031ENST00000423312+215371_725961883.0DomainKinesin motor
HgeneKIF26Achr14:104605625chr14:104379031ENST00000423312+215469_476961883.0Nucleotide bindingATP
TgeneC14orf2chr14:104605625chr14:104379031ENST000002869532420_384959.0TransmembraneHelical
TgeneC14orf2chr14:104605625chr14:104379031ENST000004142623520_386676.0TransmembraneHelical
TgeneC14orf2chr14:104605625chr14:104379031ENST000005548802420_384959.0TransmembraneHelical
TgeneC14orf2chr14:104605625chr14:104379031ENST000005570403520_384959.0TransmembraneHelical


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Fusion Gene Sequence for KIF26A-C14orf2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>42659_42659_1_KIF26A-C14orf2_KIF26A_chr14_104605625_ENST00000423312_C14orf2_chr14_104379031_ENST00000286953_length(transcript)=695nt_BP=288nt
ATGGTCGGCCGCGGCGTCCCTCTGTGCGCTGCGCAGCCCGCGGTGGCCGAGGGCGGCCCGGCCCGCGAGCCGCCGCCGCTGCTGGAGGTG
TCCCCCCGAAAGAGGCTACCCGCCGGGCCCGACCAGGACCCATGCGGCAGCCGCCCTGCTCCCGAAGGCGCCGGGGCCGGCCCAGAGCAG
GGCCACTCGGCCGGCGGAGGCGGCTGGTGCCGCCACTGCCACACGAAGCTGGTGGAGCTCAAGCGACAGGCGTGGAAGCTGGTCAGCGGG
CCCGGGACCACCCTCCGGCTTCAGCGCCTGCTCCTGGTCATCACTAACCAGATTTACTTGGAGTACATGTGAAAGAAAACGTCAGTCTGC
CTGTAAATTTCAGCAAGCCGTGTTAGATGGGGAGCGTGGAACGTCACTGTACACTTGTATAAGTACCGTTTACTTCATGGCATGAATAAA
TGGATCTGTGAGATGCACTGCTACCTGGTACTGCTTTCAGTGTGTTCCCCCTCAGCCCCTCCGGCGTGTCAGGCATACTCTGAGTAGATA
ATTTGTCATGCAGCGCATGCAATCAGAATCTCACTGAGCCACCCATCATTGTGAAATAATTACCTCAGTTGTACAGGACTTGGTGATCAG

>42659_42659_1_KIF26A-C14orf2_KIF26A_chr14_104605625_ENST00000423312_C14orf2_chr14_104379031_ENST00000286953_length(amino acids)=138AA_BP=72
MRSPRWPRAARPASRRRCWRCPPERGYPPGPTRTHAAAALLPKAPGPAQSRATRPAEAAGAATATRSWWSSSDRRGSWSAGPGPPSGFSA

--------------------------------------------------------------

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Fusion Gene PPI Analysis for KIF26A-C14orf2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for KIF26A-C14orf2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for KIF26A-C14orf2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource