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![]() | Fusion Gene Summary |
![]() | Fusion Gene ORF analysis |
![]() | Fusion Genomic Features |
![]() | Fusion Protein Features |
![]() | Fusion Gene Sequence |
![]() | Fusion Gene PPI analysis |
![]() | Related Drugs |
![]() | Related Diseases |
Fusion gene:ABCA12-SGPP2 (FusionGDB2 ID:HG26154TG130367) |
Fusion Gene Summary for ABCA12-SGPP2 |
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Fusion gene information | Fusion gene name: ABCA12-SGPP2 | Fusion gene ID: hg26154tg130367 | Hgene | Tgene | Gene symbol | ABCA12 | SGPP2 | Gene ID | 26154 | 130367 |
Gene name | ATP binding cassette subfamily A member 12 | sphingosine-1-phosphate phosphatase 2 | |
Synonyms | ARCI4A|ARCI4B|ICR2B|LI2 | SPP2|SPPase2 | |
Cytomap | ('ABCA12')('SGPP2') 2q35 | 2q36.1 | |
Type of gene | protein-coding | protein-coding | |
Description | ATP-binding cassette sub-family A member 12ATP-binding cassette transporter 12ATP-binding cassette, sub-family A (ABC1), member 12 | sphingosine-1-phosphate phosphatase 2sphingosine 1-phosphate phosphohydrolase 2sphingosine-1-phosphatase 2sphingosine-1-phosphate phosphotase 2 | |
Modification date | 20200313 | 20200313 | |
UniProtAcc | . | . | |
Ensembl transtripts involved in fusion gene | ENST00000272895, ENST00000389661, ENST00000412081, | ENST00000412081, ENST00000272895, ENST00000389661, | |
Fusion gene scores | * DoF score | 2 X 2 X 2=8 | 6 X 4 X 6=144 |
# samples | 2 | 8 | |
** MAII score | log2(2/8*10)=1.32192809488736 | log2(8/144*10)=-0.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: ABCA12 [Title/Abstract] AND SGPP2 [Title/Abstract] AND fusion [Title/Abstract] | ||
Most frequent breakpoint | ABCA12(215890397)-SGPP2(223339287), # samples:3 | ||
Anticipated loss of major functional domain due to fusion event. | ABCA12-SGPP2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. ABCA12-SGPP2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. ABCA12-SGPP2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. ABCA12-SGPP2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. SGPP2-ABCA12 seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF. SGPP2-ABCA12 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF. SGPP2-ABCA12 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF. SGPP2-ABCA12 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | ABCA12 | GO:0006869 | lipid transport | 16007253 |
Hgene | ABCA12 | GO:0010875 | positive regulation of cholesterol efflux | 23931754 |
Hgene | ABCA12 | GO:0072659 | protein localization to plasma membrane | 23931754 |
Tgene | SGPP2 | GO:0006670 | sphingosine metabolic process | 12411432 |
![]() * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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![]() * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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![]() * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChimerDB4 | ESCA | TCGA-VR-A8EU-01A | ABCA12 | chr2 | 215890397 | - | SGPP2 | chr2 | 223339287 | + |
ChimerDB4 | ESCA | TCGA-VR-A8EU | ABCA12 | chr2 | 215890397 | - | SGPP2 | chr2 | 223339287 | + |
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Fusion Gene ORF analysis for ABCA12-SGPP2 |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
In-frame | ENST00000272895 | ENST00000321276 | ABCA12 | chr2 | 215890397 | - | SGPP2 | chr2 | 223339287 | + |
In-frame | ENST00000389661 | ENST00000321276 | ABCA12 | chr2 | 215890397 | - | SGPP2 | chr2 | 223339287 | + |
intron-3CDS | ENST00000412081 | ENST00000321276 | ABCA12 | chr2 | 215890397 | - | SGPP2 | chr2 | 223339287 | + |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
ENST00000272895 | ABCA12 | chr2 | 215890397 | - | ENST00000321276 | SGPP2 | chr2 | 223339287 | + | 4538 | 1507 | 220 | 2487 | 755 |
ENST00000389661 | ABCA12 | chr2 | 215890397 | - | ENST00000321276 | SGPP2 | chr2 | 223339287 | + | 3523 | 492 | 159 | 1472 | 437 |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
ENST00000272895 | ENST00000321276 | ABCA12 | chr2 | 215890397 | - | SGPP2 | chr2 | 223339287 | + | 0.001642829 | 0.9983571 |
ENST00000389661 | ENST00000321276 | ABCA12 | chr2 | 215890397 | - | SGPP2 | chr2 | 223339287 | + | 0.000605226 | 0.9993948 |
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Fusion Genomic Features for ABCA12-SGPP2 |
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Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
ABCA12 | chr2 | 215890396 | - | SGPP2 | chr2 | 223339286 | + | 0.000373902 | 0.99962604 |
ABCA12 | chr2 | 215890396 | - | SGPP2 | chr2 | 223339286 | + | 0.000373902 | 0.99962604 |
ABCA12 | chr2 | 215890396 | - | SGPP2 | chr2 | 223339286 | + | 0.000373902 | 0.99962604 |
ABCA12 | chr2 | 215890396 | - | SGPP2 | chr2 | 223339286 | + | 0.000373902 | 0.99962604 |
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Fusion Protein Features for ABCA12-SGPP2 |
![]() Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:215890397/chr2:223339287) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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Hgene | Tgene |
. | . |
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. | FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | ABCA12 | chr2:215890397 | chr2:223339287 | ENST00000272895 | - | 11 | 53 | 23_43 | 429 | 2596.0 | Transmembrane | Helical |
Hgene | ABCA12 | chr2:215890397 | chr2:223339287 | ENST00000389661 | - | 3 | 45 | 23_43 | 111 | 2278.0 | Transmembrane | Helical |
Tgene | SGPP2 | chr2:215890397 | chr2:223339287 | ENST00000321276 | 0 | 5 | 136_144 | 73 | 400.0 | Region | Phosphatase sequence motif I | |
Tgene | SGPP2 | chr2:215890397 | chr2:223339287 | ENST00000321276 | 0 | 5 | 163_166 | 73 | 400.0 | Region | Phosphatase sequence motif II | |
Tgene | SGPP2 | chr2:215890397 | chr2:223339287 | ENST00000321276 | 0 | 5 | 206_217 | 73 | 400.0 | Region | Phosphatase sequence motif III | |
Tgene | SGPP2 | chr2:215890397 | chr2:223339287 | ENST00000321276 | 0 | 5 | 121_141 | 73 | 400.0 | Transmembrane | Helical | |
Tgene | SGPP2 | chr2:215890397 | chr2:223339287 | ENST00000321276 | 0 | 5 | 160_180 | 73 | 400.0 | Transmembrane | Helical | |
Tgene | SGPP2 | chr2:215890397 | chr2:223339287 | ENST00000321276 | 0 | 5 | 185_205 | 73 | 400.0 | Transmembrane | Helical | |
Tgene | SGPP2 | chr2:215890397 | chr2:223339287 | ENST00000321276 | 0 | 5 | 219_239 | 73 | 400.0 | Transmembrane | Helical | |
Tgene | SGPP2 | chr2:215890397 | chr2:223339287 | ENST00000321276 | 0 | 5 | 247_267 | 73 | 400.0 | Transmembrane | Helical | |
Tgene | SGPP2 | chr2:215890397 | chr2:223339287 | ENST00000321276 | 0 | 5 | 280_300 | 73 | 400.0 | Transmembrane | Helical | |
Tgene | SGPP2 | chr2:215890397 | chr2:223339287 | ENST00000321276 | 0 | 5 | 318_338 | 73 | 400.0 | Transmembrane | Helical | |
Tgene | SGPP2 | chr2:215890397 | chr2:223339287 | ENST00000321276 | 0 | 5 | 371_391 | 73 | 400.0 | Transmembrane | Helical | |
Tgene | SGPP2 | chr2:215890397 | chr2:223339287 | ENST00000321276 | 0 | 5 | 88_108 | 73 | 400.0 | Transmembrane | Helical |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | ABCA12 | chr2:215890397 | chr2:223339287 | ENST00000272895 | - | 11 | 53 | 1346_1577 | 429 | 2596.0 | Domain | ABC transporter 1 |
Hgene | ABCA12 | chr2:215890397 | chr2:223339287 | ENST00000272895 | - | 11 | 53 | 2254_2489 | 429 | 2596.0 | Domain | ABC transporter 2 |
Hgene | ABCA12 | chr2:215890397 | chr2:223339287 | ENST00000389661 | - | 3 | 45 | 1346_1577 | 111 | 2278.0 | Domain | ABC transporter 1 |
Hgene | ABCA12 | chr2:215890397 | chr2:223339287 | ENST00000389661 | - | 3 | 45 | 2254_2489 | 111 | 2278.0 | Domain | ABC transporter 2 |
Hgene | ABCA12 | chr2:215890397 | chr2:223339287 | ENST00000272895 | - | 11 | 53 | 1378_1385 | 429 | 2596.0 | Nucleotide binding | ATP 1 |
Hgene | ABCA12 | chr2:215890397 | chr2:223339287 | ENST00000272895 | - | 11 | 53 | 2290_2297 | 429 | 2596.0 | Nucleotide binding | ATP 2 |
Hgene | ABCA12 | chr2:215890397 | chr2:223339287 | ENST00000389661 | - | 3 | 45 | 1378_1385 | 111 | 2278.0 | Nucleotide binding | ATP 1 |
Hgene | ABCA12 | chr2:215890397 | chr2:223339287 | ENST00000389661 | - | 3 | 45 | 2290_2297 | 111 | 2278.0 | Nucleotide binding | ATP 2 |
Hgene | ABCA12 | chr2:215890397 | chr2:223339287 | ENST00000272895 | - | 11 | 53 | 1065_1085 | 429 | 2596.0 | Transmembrane | Helical |
Hgene | ABCA12 | chr2:215890397 | chr2:223339287 | ENST00000272895 | - | 11 | 53 | 1112_1132 | 429 | 2596.0 | Transmembrane | Helical |
Hgene | ABCA12 | chr2:215890397 | chr2:223339287 | ENST00000272895 | - | 11 | 53 | 1145_1165 | 429 | 2596.0 | Transmembrane | Helical |
Hgene | ABCA12 | chr2:215890397 | chr2:223339287 | ENST00000272895 | - | 11 | 53 | 1174_1194 | 429 | 2596.0 | Transmembrane | Helical |
Hgene | ABCA12 | chr2:215890397 | chr2:223339287 | ENST00000272895 | - | 11 | 53 | 1200_1220 | 429 | 2596.0 | Transmembrane | Helical |
Hgene | ABCA12 | chr2:215890397 | chr2:223339287 | ENST00000272895 | - | 11 | 53 | 1250_1270 | 429 | 2596.0 | Transmembrane | Helical |
Hgene | ABCA12 | chr2:215890397 | chr2:223339287 | ENST00000272895 | - | 11 | 53 | 1747_1767 | 429 | 2596.0 | Transmembrane | Helical |
Hgene | ABCA12 | chr2:215890397 | chr2:223339287 | ENST00000272895 | - | 11 | 53 | 1979_1999 | 429 | 2596.0 | Transmembrane | Helical |
Hgene | ABCA12 | chr2:215890397 | chr2:223339287 | ENST00000272895 | - | 11 | 53 | 2035_2055 | 429 | 2596.0 | Transmembrane | Helical |
Hgene | ABCA12 | chr2:215890397 | chr2:223339287 | ENST00000272895 | - | 11 | 53 | 2072_2092 | 429 | 2596.0 | Transmembrane | Helical |
Hgene | ABCA12 | chr2:215890397 | chr2:223339287 | ENST00000272895 | - | 11 | 53 | 2103_2123 | 429 | 2596.0 | Transmembrane | Helical |
Hgene | ABCA12 | chr2:215890397 | chr2:223339287 | ENST00000272895 | - | 11 | 53 | 2187_2207 | 429 | 2596.0 | Transmembrane | Helical |
Hgene | ABCA12 | chr2:215890397 | chr2:223339287 | ENST00000272895 | - | 11 | 53 | 2270_2290 | 429 | 2596.0 | Transmembrane | Helical |
Hgene | ABCA12 | chr2:215890397 | chr2:223339287 | ENST00000389661 | - | 3 | 45 | 1065_1085 | 111 | 2278.0 | Transmembrane | Helical |
Hgene | ABCA12 | chr2:215890397 | chr2:223339287 | ENST00000389661 | - | 3 | 45 | 1112_1132 | 111 | 2278.0 | Transmembrane | Helical |
Hgene | ABCA12 | chr2:215890397 | chr2:223339287 | ENST00000389661 | - | 3 | 45 | 1145_1165 | 111 | 2278.0 | Transmembrane | Helical |
Hgene | ABCA12 | chr2:215890397 | chr2:223339287 | ENST00000389661 | - | 3 | 45 | 1174_1194 | 111 | 2278.0 | Transmembrane | Helical |
Hgene | ABCA12 | chr2:215890397 | chr2:223339287 | ENST00000389661 | - | 3 | 45 | 1200_1220 | 111 | 2278.0 | Transmembrane | Helical |
Hgene | ABCA12 | chr2:215890397 | chr2:223339287 | ENST00000389661 | - | 3 | 45 | 1250_1270 | 111 | 2278.0 | Transmembrane | Helical |
Hgene | ABCA12 | chr2:215890397 | chr2:223339287 | ENST00000389661 | - | 3 | 45 | 1747_1767 | 111 | 2278.0 | Transmembrane | Helical |
Hgene | ABCA12 | chr2:215890397 | chr2:223339287 | ENST00000389661 | - | 3 | 45 | 1979_1999 | 111 | 2278.0 | Transmembrane | Helical |
Hgene | ABCA12 | chr2:215890397 | chr2:223339287 | ENST00000389661 | - | 3 | 45 | 2035_2055 | 111 | 2278.0 | Transmembrane | Helical |
Hgene | ABCA12 | chr2:215890397 | chr2:223339287 | ENST00000389661 | - | 3 | 45 | 2072_2092 | 111 | 2278.0 | Transmembrane | Helical |
Hgene | ABCA12 | chr2:215890397 | chr2:223339287 | ENST00000389661 | - | 3 | 45 | 2103_2123 | 111 | 2278.0 | Transmembrane | Helical |
Hgene | ABCA12 | chr2:215890397 | chr2:223339287 | ENST00000389661 | - | 3 | 45 | 2187_2207 | 111 | 2278.0 | Transmembrane | Helical |
Hgene | ABCA12 | chr2:215890397 | chr2:223339287 | ENST00000389661 | - | 3 | 45 | 2270_2290 | 111 | 2278.0 | Transmembrane | Helical |
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Fusion Gene Sequence for ABCA12-SGPP2 |
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>151_151_1_ABCA12-SGPP2_ABCA12_chr2_215890397_ENST00000272895_SGPP2_chr2_223339287_ENST00000321276_length(transcript)=4538nt_BP=1507nt GAAGAGTTGATTGAGAAGTGCCTCTTGGTTAAGGATTAACCACAGGGAAAAATCCAGCAGAAACAGAAGAACTGTGGGTTTCTTACCCCA GCCCTCAAGGAAGCTATGCCGTGAAAGGGGTACTGATACACTGACATACAGCAAGTTGGACGGGGCATCAGTTCTTCATTTGTGGAGTGG AGAAAAGAAGAGGAAATCTCTCATTTGGGGCATTTGAAGGATGGCTTCCCTGTTTCATCAGCTTCAGATCCTGGTCTGGAAAAATTGGCT AGGTGTAAAAAGGCAGCCGCTTTGGACACTTGTCTTGATCTTATGGCCAGTCATTATTTTCATAATTTTGGCTATTACTCGGACCAAATT TCCTCCAACTGCAAAACCAACTTGTTACCTCGCACCTCGAAACCTTCCTAGTACTGGATTCTTTCCATTCCTGCAGACCCTACTCTGTGA CACAGACTCTAAATGCAAAGACACACCCTATGGCCCACAAGATCTGCTTCGTAGGAAAGGAATTGATGATGCACTATTTAAAGACAGTGA GATTCTGAGAAAGTCATCCAACCTGGATAAGGACAGCAGTTTATCATTCCAGAGCACCCAAGTTCCAGAAAGAAGGCATGCATCACTAGC CACAGTATTTCCCAGTCCAAGTTCTGATTTGGAAATCCCCGGAACATATACTTTCAATGGCAGTCAAGTGCTCGCACGAATTCTTGGCTT GGAAAAGCTGTTAAAGCAAAATTCAACTTCAGAAGATATACGAAGAGAACTATGTGACAGCTATTCAGGATACATTGTGGATGATGCCTT CTCTTGGACCTTTCTAGGAAGAAATGTTTTTAACAAATTTTGCCTTTCTAACATGACCCTTTTAGAGTCTTCTCTCCAAGAACTAAACAA ACAGTTCTCCCAGCTATCCAGTGACCCCAACAATCAGAAGATAGTGTTTCAGGAAATAGTCAGAATGCTGTCTTTCTTCTCACAAGTGCA AGAGCAGAAAGCTGTGTGGCAGCTTCTGTCTAGTTTTCCAAATGTGTTTCAGAATGACACATCACTAAGCAATCTATTTGATGTTCTTCG AAAGGCAAACAGTGTGCTGCTGGTTGTGCAGAAGGTTTATCCACGTTTTGCAACTAACGAAGGTTTCAGAACCCTCCAGAAGTCTGTTAA ACATCTGCTGTACACTCTGGACTCCCCAGCTCAAGGTGACTCCGATAATATAACGCATGTGTGGAATGAGGATGATGGACAGACCTTATC TCCAAGCAGTCTGGCTGCACAGCTCCTAATTCTGGAAAACTTTGAAGATGCCCTCTTAAATATATCAGCAAATAGTCCTTATATTCCTTA CTTGGCATGTGTGAGAAATGTGACTGACAGTTTGGCCAGAGGTTCACCAGAAAATCTAAGACTCCTGCAGTCCACAATACGATTTAAAAA ATCTTTTCTTCGCAATGGTTCCTATGAAGATTACTTTCCTCCAGTTCCTGAAGTCCTAAAATCAAAAGCTTATGTACAGAAGTACGTCGT GAAGAATTATTTCTACTATTACCTATTCCAATTTTCAGCTGCTTTGGGCCAAGAAGTGTTCTACATCACGTTTCTTCCATTCACTCACTG GAATATTGACCCTTATTTATCCAGAAGATTGATCATCATATGGGTTTTGGTGATGTATATTGGCCAAGTGGCCAAGGATGTCTTGAAGTG GCCCCGTCCCTCCTCCCCTCCAGTTGTAAAACTGGAAAAGAGACTGATCGCTGAATATGGAATGCCATCCACCCACGCCATGGCGGCCAC TGCCATTGCCTTCACCCTCCTTATCTCTACTATGGACAGATACCAGTATCCATTTGTGTTGGGACTGGTGATGGCCGTGGTGTTTTCCAC CTTGGTGTGTCTCAGCAGGCTCTACACTGGGATGCATACGGTCCTGGATGTGCTGGGTGGCGTCCTGATCACCGCACTCCTCATCGTCCT CACCTACCCTGCCTGGACCTTCATCGACTGCCTGGACTCGGCCAGCCCCCTCTTCCCCGTGTGTGTCATAGTTGTGCCATTCTTCCTGTG TTACAATTACCCTGTTTCTGATTACTACAGCCCAACCCGGGCGGACACCACCACCATTCTGGCTGCCGGGGCTGGAGTGACCATAGGATT CTGGATCAACCATTTCTTCCAGCTTGTATCCAAGCCCGCTGAATCTCTCCCTGTTATTCAGAACATCCCACCACTCACCACCTACATGTT AGTTTTGGGTCTGACCAAATTTGCAGTGGGAATTGTGTTGATCCTCTTGGTTCGTCAGCTTGTACAAAATCTCTCACTGCAAGTATTATA CTCATGGTTCAAGGTGGTCACCAGGAACAAGGAGGCCAGGCGGAGACTGGAGATTGAAGTGCCTTACAAGTTTGTTACCTACACATCTGT TGGCATCTGCGCTACAACCTTTGTGCCGATGCTTCACAGGTTTCTGGGATTACCCTGAGTCTCAAACAGTTGGAAACTAGCCCACTGGAC ATGAAAGCCAAGACATAGGAAAGTTATTGGTAGGCAAATCTTGACAACTTATTTTTCTTTAACAACAACAAAAAGTCATACGGCTGTCTT GCTACTACCAGATAAATGATGCTGCTGTGTGAAAGGAAGAACTGTCTCATAGCGGTCATTGGTCGTCCGTGGTGGTTGGTTGTGCTACAG TTGAACCCAGGCTAAAGACCATAATCCGGATCTTTAAAGGCACACACCGCGCCCCCCCCCCCCCCGCCCGGCCCCTGCTCCTCTCGCTGT TGCACGGGCTTTGGATCTAGTCATGGGCTGGCAGGAATTGTGGCCTGGCTTAGGAATAGCTATGAGCCCCACTGGGTTCTGGAGAGCCAG TAGAGATGGGGTGATCTGGGAGGCTGGAGGTAGAGCCTTTCTTTTCCGTTACAACCTTGCCTAGCATGGAGTTATTTCTAAAATGGGAAC TTTGGTCTAGGAGAAGGGGTGGCACCATATGAAACGGCATTCCTTGGACAGGGTGACTTCCTTATCGTTTATTTGGTGATTTTTTGTTTT GTTTTGTTTGAGACAGGATCTTGCTCTGTTTCCCAGGCTGTATTACAGTGGCACAATCTCAGCTCACTGCAAACTCTGCCTCCCGGGCTC AAGCAATCCTCCTGCCTGAGCCAACTGAGTAGCTGGGACTGTAAGCATAGACCACCATGTGCCCAGCTAATTTTTGTAGAGACAGGGTTT CTCCATGTTGCCCAGGTACGTCTGAAACTCCTGGGCTTAAGTGATCCACCCACCTCAGCCTCCCAAAGTGCTGGGATTATAGGCATGAGC CACTGTGCCCGGCCTCCTCCTTGTTATGATCAAATTAGACTGTGCCTGGTTGGGTGGTAAGATCACTCTGAAAGAAAGCTCACTGTGAAG AGATGAAAGGTGGAGGCAGAGCTGTGAGGTCATGGGGAAAAGCCTGCTTTCCTTATAAGTCCTGCTGTTCATGTTGGAATAAGGATCTGC TCTTCCTTGTTTCCATGCATTTTGCAGGATTCCAGGTACCATTACCACACTCTTCTGACCCATGAAACCAACTGGCTGCTCACACATCAC CAAACAGGTTGGGGGTTAGCCTTCAGCACAGGTGGATACATCTGGGATTCACTGAGATTCCTGCCCTCTCCTGCTTCCTAGTGGTTTGGG ACAGGCCCTCTGCCCATCGTCAGCAGTTTTTTGCTTTCATACAAACCTGGAAGGCACTGGCATCTGCCTAGGAAAGTGGATCTGTGAAGA ACAGATGAACTCAATCCTTTCTGGAGTCTGACAAAGAAGGGATAGGCTTCCTTGACATTGCCTGTCCTGACAAGGCCTCCCTGACATTAC TCCTCCAATTTCACAGTTACCTTCTGTAAATCTATTTTCTCATCTACTGAATAGAATCAGGCGCCCTTTTTGTCTTCCCACCTCTTATCT CTTGGCAATTTTAAGGGGAATTAATGCAAGAACAACTTTAGTGTCTCTTGGGAAAACAAGCCAACCAAATACAAAACCCATTAAGCCTAC TAGGGTGAGTCCTCTTAACATGGGAAGGCGATGATTATGCAAACACCGGAGTTCCCTCCTCTTCAGTTCCTAAGAATAAAGAACAGGTAT CAAGAACTTTCTTTAAAGTTAGTGTAACTATAGTTAACAAAGTATCCATTGAAGTTTAGTGCCTGTAGGACTGAGCCAGTGCTTTATCAA CCCAACACATCATCACCATGTGCATACTCTAGAAAAAAAAATAGCTTCCTTAAAAGTTACAGAGGCTCTTAACGTGTTAAAACCGAAAAA TCACATTTTTCTTGATTTCAAATATGTTCTACGGCCTTACTGTTGGGATGATATTTAGTATGTAACTTAGCATTCCAATTTCTCAAGAAT TTTTAGGCCGGGTGCGGTGGCTCATGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGTGGGCGGACCACGAGGTCAGGAGATCGAGACCA >151_151_1_ABCA12-SGPP2_ABCA12_chr2_215890397_ENST00000272895_SGPP2_chr2_223339287_ENST00000321276_length(amino acids)=755AA_BP=429 MASLFHQLQILVWKNWLGVKRQPLWTLVLILWPVIIFIILAITRTKFPPTAKPTCYLAPRNLPSTGFFPFLQTLLCDTDSKCKDTPYGPQ DLLRRKGIDDALFKDSEILRKSSNLDKDSSLSFQSTQVPERRHASLATVFPSPSSDLEIPGTYTFNGSQVLARILGLEKLLKQNSTSEDI RRELCDSYSGYIVDDAFSWTFLGRNVFNKFCLSNMTLLESSLQELNKQFSQLSSDPNNQKIVFQEIVRMLSFFSQVQEQKAVWQLLSSFP NVFQNDTSLSNLFDVLRKANSVLLVVQKVYPRFATNEGFRTLQKSVKHLLYTLDSPAQGDSDNITHVWNEDDGQTLSPSSLAAQLLILEN FEDALLNISANSPYIPYLACVRNVTDSLARGSPENLRLLQSTIRFKKSFLRNGSYEDYFPPVPEVLKSKAYVQKYVVKNYFYYYLFQFSA ALGQEVFYITFLPFTHWNIDPYLSRRLIIIWVLVMYIGQVAKDVLKWPRPSSPPVVKLEKRLIAEYGMPSTHAMAATAIAFTLLISTMDR YQYPFVLGLVMAVVFSTLVCLSRLYTGMHTVLDVLGGVLITALLIVLTYPAWTFIDCLDSASPLFPVCVIVVPFFLCYNYPVSDYYSPTR ADTTTILAAGAGVTIGFWINHFFQLVSKPAESLPVIQNIPPLTTYMLVLGLTKFAVGIVLILLVRQLVQNLSLQVLYSWFKVVTRNKEAR -------------------------------------------------------------- >151_151_2_ABCA12-SGPP2_ABCA12_chr2_215890397_ENST00000389661_SGPP2_chr2_223339287_ENST00000321276_length(transcript)=3523nt_BP=492nt ATTTCCTATAAATATCACAAATATTTCCAACAAAAGAGCATAGATGTCTTTTATACAATTCTTTTGAGAATGATTCTGCAGATTTCTGCA TTTTCTCCTCATTAATTTGACCTGGGATGGTTTTCACTGAGGAAAAAAATCTTTAAGCAAACATGTTAAATGTTTACCTATATAAAAATT ATTACTTCAGGTGACTCCGATAATATAACGCATGTGTGGAATGAGGATGATGGACAGACCTTATCTCCAAGCAGTCTGGCTGCACAGCTC CTAATTCTGGAAAACTTTGAAGATGCCCTCTTAAATATATCAGCAAATAGTCCTTATATTCCTTACTTGGCATGTGTGAGAAATGTGACT GACAGTTTGGCCAGAGGTTCACCAGAAAATCTAAGACTCCTGCAGTCCACAATACGATTTAAAAAATCTTTTCTTCGCAATGGTTCCTAT GAAGATTACTTTCCTCCAGTTCCTGAAGTCCTAAAATCAAAAGCTTATGTACAGAAGTACGTCGTGAAGAATTATTTCTACTATTACCTA TTCCAATTTTCAGCTGCTTTGGGCCAAGAAGTGTTCTACATCACGTTTCTTCCATTCACTCACTGGAATATTGACCCTTATTTATCCAGA AGATTGATCATCATATGGGTTTTGGTGATGTATATTGGCCAAGTGGCCAAGGATGTCTTGAAGTGGCCCCGTCCCTCCTCCCCTCCAGTT GTAAAACTGGAAAAGAGACTGATCGCTGAATATGGAATGCCATCCACCCACGCCATGGCGGCCACTGCCATTGCCTTCACCCTCCTTATC TCTACTATGGACAGATACCAGTATCCATTTGTGTTGGGACTGGTGATGGCCGTGGTGTTTTCCACCTTGGTGTGTCTCAGCAGGCTCTAC ACTGGGATGCATACGGTCCTGGATGTGCTGGGTGGCGTCCTGATCACCGCACTCCTCATCGTCCTCACCTACCCTGCCTGGACCTTCATC GACTGCCTGGACTCGGCCAGCCCCCTCTTCCCCGTGTGTGTCATAGTTGTGCCATTCTTCCTGTGTTACAATTACCCTGTTTCTGATTAC TACAGCCCAACCCGGGCGGACACCACCACCATTCTGGCTGCCGGGGCTGGAGTGACCATAGGATTCTGGATCAACCATTTCTTCCAGCTT GTATCCAAGCCCGCTGAATCTCTCCCTGTTATTCAGAACATCCCACCACTCACCACCTACATGTTAGTTTTGGGTCTGACCAAATTTGCA GTGGGAATTGTGTTGATCCTCTTGGTTCGTCAGCTTGTACAAAATCTCTCACTGCAAGTATTATACTCATGGTTCAAGGTGGTCACCAGG AACAAGGAGGCCAGGCGGAGACTGGAGATTGAAGTGCCTTACAAGTTTGTTACCTACACATCTGTTGGCATCTGCGCTACAACCTTTGTG CCGATGCTTCACAGGTTTCTGGGATTACCCTGAGTCTCAAACAGTTGGAAACTAGCCCACTGGACATGAAAGCCAAGACATAGGAAAGTT ATTGGTAGGCAAATCTTGACAACTTATTTTTCTTTAACAACAACAAAAAGTCATACGGCTGTCTTGCTACTACCAGATAAATGATGCTGC TGTGTGAAAGGAAGAACTGTCTCATAGCGGTCATTGGTCGTCCGTGGTGGTTGGTTGTGCTACAGTTGAACCCAGGCTAAAGACCATAAT CCGGATCTTTAAAGGCACACACCGCGCCCCCCCCCCCCCCGCCCGGCCCCTGCTCCTCTCGCTGTTGCACGGGCTTTGGATCTAGTCATG GGCTGGCAGGAATTGTGGCCTGGCTTAGGAATAGCTATGAGCCCCACTGGGTTCTGGAGAGCCAGTAGAGATGGGGTGATCTGGGAGGCT GGAGGTAGAGCCTTTCTTTTCCGTTACAACCTTGCCTAGCATGGAGTTATTTCTAAAATGGGAACTTTGGTCTAGGAGAAGGGGTGGCAC CATATGAAACGGCATTCCTTGGACAGGGTGACTTCCTTATCGTTTATTTGGTGATTTTTTGTTTTGTTTTGTTTGAGACAGGATCTTGCT CTGTTTCCCAGGCTGTATTACAGTGGCACAATCTCAGCTCACTGCAAACTCTGCCTCCCGGGCTCAAGCAATCCTCCTGCCTGAGCCAAC TGAGTAGCTGGGACTGTAAGCATAGACCACCATGTGCCCAGCTAATTTTTGTAGAGACAGGGTTTCTCCATGTTGCCCAGGTACGTCTGA AACTCCTGGGCTTAAGTGATCCACCCACCTCAGCCTCCCAAAGTGCTGGGATTATAGGCATGAGCCACTGTGCCCGGCCTCCTCCTTGTT ATGATCAAATTAGACTGTGCCTGGTTGGGTGGTAAGATCACTCTGAAAGAAAGCTCACTGTGAAGAGATGAAAGGTGGAGGCAGAGCTGT GAGGTCATGGGGAAAAGCCTGCTTTCCTTATAAGTCCTGCTGTTCATGTTGGAATAAGGATCTGCTCTTCCTTGTTTCCATGCATTTTGC AGGATTCCAGGTACCATTACCACACTCTTCTGACCCATGAAACCAACTGGCTGCTCACACATCACCAAACAGGTTGGGGGTTAGCCTTCA GCACAGGTGGATACATCTGGGATTCACTGAGATTCCTGCCCTCTCCTGCTTCCTAGTGGTTTGGGACAGGCCCTCTGCCCATCGTCAGCA GTTTTTTGCTTTCATACAAACCTGGAAGGCACTGGCATCTGCCTAGGAAAGTGGATCTGTGAAGAACAGATGAACTCAATCCTTTCTGGA GTCTGACAAAGAAGGGATAGGCTTCCTTGACATTGCCTGTCCTGACAAGGCCTCCCTGACATTACTCCTCCAATTTCACAGTTACCTTCT GTAAATCTATTTTCTCATCTACTGAATAGAATCAGGCGCCCTTTTTGTCTTCCCACCTCTTATCTCTTGGCAATTTTAAGGGGAATTAAT GCAAGAACAACTTTAGTGTCTCTTGGGAAAACAAGCCAACCAAATACAAAACCCATTAAGCCTACTAGGGTGAGTCCTCTTAACATGGGA AGGCGATGATTATGCAAACACCGGAGTTCCCTCCTCTTCAGTTCCTAAGAATAAAGAACAGGTATCAAGAACTTTCTTTAAAGTTAGTGT AACTATAGTTAACAAAGTATCCATTGAAGTTTAGTGCCTGTAGGACTGAGCCAGTGCTTTATCAACCCAACACATCATCACCATGTGCAT ACTCTAGAAAAAAAAATAGCTTCCTTAAAAGTTACAGAGGCTCTTAACGTGTTAAAACCGAAAAATCACATTTTTCTTGATTTCAAATAT GTTCTACGGCCTTACTGTTGGGATGATATTTAGTATGTAACTTAGCATTCCAATTTCTCAAGAATTTTTAGGCCGGGTGCGGTGGCTCAT GCCTGTAATCCCAGCACTTTGGGAGGCCGAGGTGGGCGGACCACGAGGTCAGGAGATCGAGACCATCCTGGCTAACACGGTACCCCGTCT >151_151_2_ABCA12-SGPP2_ABCA12_chr2_215890397_ENST00000389661_SGPP2_chr2_223339287_ENST00000321276_length(amino acids)=437AA_BP=111 MFTYIKIITSGDSDNITHVWNEDDGQTLSPSSLAAQLLILENFEDALLNISANSPYIPYLACVRNVTDSLARGSPENLRLLQSTIRFKKS FLRNGSYEDYFPPVPEVLKSKAYVQKYVVKNYFYYYLFQFSAALGQEVFYITFLPFTHWNIDPYLSRRLIIIWVLVMYIGQVAKDVLKWP RPSSPPVVKLEKRLIAEYGMPSTHAMAATAIAFTLLISTMDRYQYPFVLGLVMAVVFSTLVCLSRLYTGMHTVLDVLGGVLITALLIVLT YPAWTFIDCLDSASPLFPVCVIVVPFFLCYNYPVSDYYSPTRADTTTILAAGAGVTIGFWINHFFQLVSKPAESLPVIQNIPPLTTYMLV -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for ABCA12-SGPP2 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for ABCA12-SGPP2 |
![]() (DrugBank Version 5.1.8 2021-05-08) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for ABCA12-SGPP2 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | ABCA12 | C0079154 | Congenital Nonbullous Ichthyosiform Erythroderma | 5 | CTD_human;GENOMICS_ENGLAND;ORPHANET |
Hgene | ABCA12 | C1832550 | Lamellar ichthyosis, type 2 | 5 | CTD_human;GENOMICS_ENGLAND;UNIPROT |
Hgene | ABCA12 | C0598226 | Harlequin type ichthyosis | 3 | CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT |
Hgene | ABCA12 | C0239849 | Harlequin Fetus | 2 | CTD_human;GENOMICS_ENGLAND;ORPHANET |
Hgene | ABCA12 | C0009402 | Colorectal Carcinoma | 1 | CTD_human |
Hgene | ABCA12 | C0009404 | Colorectal Neoplasms | 1 | CTD_human |
Hgene | ABCA12 | C0020758 | Congenital ichthyosis | 1 | CTD_human |
Hgene | ABCA12 | C3536797 | Ichthyosis Congenita II | 1 | CTD_human |
Hgene | ABCA12 | C3543867 | Collodion Fetus | 1 | CTD_human |
Hgene | ABCA12 | C4551630 | Ichthyosis Congenita I | 1 | CTD_human |