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in Kim Lab

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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:AMD1-MBOAT2 (FusionGDB2 ID:HG262TG129642)

Fusion Gene Summary for AMD1-MBOAT2

check button Fusion gene summary
Fusion gene informationFusion gene name: AMD1-MBOAT2
Fusion gene ID: hg262tg129642
HgeneTgene
Gene symbol

AMD1

MBOAT2

Gene ID

262

129642

Gene nameadenosylmethionine decarboxylase 1membrane bound O-acyltransferase domain containing 2
SynonymsADOMETDC|AMD|SAMDCLPAAT|LPCAT4|LPEAT|LPLAT 2|OACT2
Cytomap('AMD1')('MBOAT2')

6q21

2p25.1

Type of geneprotein-codingprotein-coding
DescriptionS-adenosylmethionine decarboxylase proenzymeS-adenosylmethionine decarboxylase 1lysophospholipid acyltransferase 21-acylglycerophosphate O-acyltransferase1-acylglycerophosphoethanolamine O-acyltransferaseO-acyltransferase (membrane bound) domain containing 2lyso-PA acyltransferaselyso-PE acyltransferaselysophosphatidic acid acy
Modification date2020031320200320
UniProtAcc.

Q6ZWT7

Ensembl transtripts involved in fusion geneENST00000368876, ENST00000368877, 
ENST00000368885, ENST00000368882, 
ENST00000451850, 
Fusion gene scores* DoF score15 X 13 X 4=78014 X 12 X 9=1512
# samples 1515
** MAII scorelog2(15/780*10)=-2.37851162325373
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(15/1512*10)=-3.33342373372519
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: AMD1 [Title/Abstract] AND MBOAT2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointAMD1(111210186)-MBOAT2(9004364), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across AMD1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across MBOAT2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4PRADTCGA-EJ-A7NK-01AAMD1chr6

111210186

+MBOAT2chr2

9004364

-
ChimerDB4PRADTCGA-EJ-A7NKAMD1chr6

111210186

+MBOAT2chr2

9004364

-


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Fusion Gene ORF analysis for AMD1-MBOAT2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000368876ENST00000486484AMD1chr6

111210186

+MBOAT2chr2

9004364

-
5CDS-5UTRENST00000368877ENST00000486484AMD1chr6

111210186

+MBOAT2chr2

9004364

-
5CDS-5UTRENST00000368885ENST00000486484AMD1chr6

111210186

+MBOAT2chr2

9004364

-
In-frameENST00000368876ENST00000305997AMD1chr6

111210186

+MBOAT2chr2

9004364

-
In-frameENST00000368877ENST00000305997AMD1chr6

111210186

+MBOAT2chr2

9004364

-
In-frameENST00000368885ENST00000305997AMD1chr6

111210186

+MBOAT2chr2

9004364

-
intron-3CDSENST00000368882ENST00000305997AMD1chr6

111210186

+MBOAT2chr2

9004364

-
intron-3CDSENST00000451850ENST00000305997AMD1chr6

111210186

+MBOAT2chr2

9004364

-
intron-5UTRENST00000368882ENST00000486484AMD1chr6

111210186

+MBOAT2chr2

9004364

-
intron-5UTRENST00000451850ENST00000486484AMD1chr6

111210186

+MBOAT2chr2

9004364

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000368885AMD1chr6111210186+ENST00000305997MBOAT2chr29004364-72256602941235313
ENST00000368877AMD1chr6111210186+ENST00000305997MBOAT2chr29004364-71235582791133284
ENST00000368876AMD1chr6111210186+ENST00000305997MBOAT2chr29004364-682726267837256

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000368885ENST00000305997AMD1chr6111210186+MBOAT2chr29004364-0.0101809970.989819
ENST00000368877ENST00000305997AMD1chr6111210186+MBOAT2chr29004364-0.008852980.991147
ENST00000368876ENST00000305997AMD1chr6111210186+MBOAT2chr29004364-0.0120634150.98793656

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Fusion Genomic Features for AMD1-MBOAT2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for AMD1-MBOAT2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr6:111210186/chr2:9004364)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.MBOAT2

Q6ZWT7

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Acyltransferase which catalyzes the transfert of an acyl group from an acyl-CoA to a lysophospholipid leading to the production of a phospholipid and participates in the reacylation step of the phospholipid remodeling pathway also known as the Lands cycle (PubMed:18772128). Catalyzes preferentially the acylation of lysophosphatidylethanolamine (1-acyl-sn-glycero-3-phosphoethanolamine or LPE) and lysophosphatidic acid (LPA) and to a lesser extend lysophosphatidylcholine (LPC) and lysophosphatidylserine (LPS) (PubMed:18772128). Prefers oleoyl-CoA as the acyl donor (PubMed:18772128). May be involved in chondrocyte differentiation (By similarity). {ECO:0000250|UniProtKB:Q8R3I2, ECO:0000269|PubMed:18772128}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneMBOAT2chr6:111210186chr2:9004364ENST00000305997813366_386329521.0TransmembraneHelical
TgeneMBOAT2chr6:111210186chr2:9004364ENST00000305997813416_436329521.0TransmembraneHelical
TgeneMBOAT2chr6:111210186chr2:9004364ENST00000305997813444_464329521.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneMBOAT2chr6:111210186chr2:9004364ENST00000305997813184_204329521.0TransmembraneHelical
TgeneMBOAT2chr6:111210186chr2:9004364ENST0000030599781322_42329521.0TransmembraneHelical
TgeneMBOAT2chr6:111210186chr2:9004364ENST00000305997813237_257329521.0TransmembraneHelical
TgeneMBOAT2chr6:111210186chr2:9004364ENST00000305997813264_284329521.0TransmembraneHelical
TgeneMBOAT2chr6:111210186chr2:9004364ENST0000030599781361_81329521.0TransmembraneHelical
TgeneMBOAT2chr6:111210186chr2:9004364ENST0000030599781388_108329521.0TransmembraneHelical


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Fusion Gene Sequence for AMD1-MBOAT2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>4197_4197_1_AMD1-MBOAT2_AMD1_chr6_111210186_ENST00000368876_MBOAT2_chr2_9004364_ENST00000305997_length(transcript)=6827nt_BP=262nt
GGGCCCCAGGTGGGGGTCGGGGGCGCCTGCGCGGGTTGCCTCCGGCAGATCTGAGTGGGACATACTTTTGAAGGATGTGCAATGTTCAAT
CATAAGTGTGACAAAAACTGACAAGCAGGAAGCTTATGTACTCAGTGAGAGTAGCATGTTTGTCTCCAAGAGACGTTTCATTTTGAAGAC
ATGTGGTACCACCCTCTTGCTGAAAGCACTGGTTCCCCTGTTGAAGCTTGCTAGGGATTACAGTGGGTTTGACTCAATTCAAATGTCAAC
AAGTTTCAAGATGTTTCTTGATAATTGGAATATTCAGACAGCTCTTTGGCTCAAAAGGGTGTGTTATGAACGAACCTCCTTCAGTCCAAC
TATCCAGACGTTCATTCTCTCTGCCATTTGGCACGGGGTATACCCAGGATATTATCTAACGTTTCTAACAGGGGTGTTAATGACATTAGC
AGCAAGAGCTATGAGAAATAACTTTAGACATTATTTCATTGAACCTTCCCAACTGAAATTATTTTATGATGTTATAACATGGATAGTAAC
TCAAGTAGCAATAAGTTACACAGTTGTGCCATTTGTGCTTCTTTCTATAAAACCATCACTCACGTTTTACAGCTCCTGGTATTATTGCCT
GCACATTCTTGGTATCTTAGTATTATTGTTGTTGCCAGTGAAAAAAACTCAAAGAAGAAAGAATACACATGAAAACATTCAGCTCTCACA
ATCCAAAAAGTTTGATGAAGGAGAAAATTCTTTGGGACAGAACAGTTTTTCTACAACAAACAATGTTTGCAATCAGAATCAAGAAATAGC
CTCGAGACATTCATCACTAAAGCAGTGATCGGGAAGGCTCTGAGGGCTGTTTTTTTTTTTTGATGTTAACAGAAACCAATCTTAGCACCT
TTTCAAGGGGTTTGAGTTTGTTGGAAAAGCAGTTAACTGGGGGGAAATGGACAGTTATAGATAAGGAATTTCCTGTACACCAGATTGGAA
ATGGAGTGAAACAAGCCCTCCCATGCCATGTCTCCGTGGGCCACGCCTTATGTAAGAATATTTCCATATTTCAGTGGGCACTCCCAACCT
CAGCACTTGTCCGTAGGGTCACACGCGTGCCCTGTTGCTGAATGTATGTTGCGTATCCCAAGGCACTGAAGAGGTGGAAAAATAATCGTG
TCAATCTGGATGATAGAGAGAAATTAACTTTTCCAAATGAATGTCTTGCCTTAAACCCTCTATTTCCTAAAATATTGTTCCTAAATGGTA
TTTTCAAGTGTAATATTGTGAGAACGCTACTGCAGTAGTTGATGTTGTGTGCTGTAAAGGATTTTAGGAGGAATTTGAAACAGGATATTT
AAGAGTGTGGATATTTTTAAAATGCAATAAACATCTCAGTATTTGAAGGGTTTTCTTAAAGTATGTCAAATGACTACAATCCATAGTGAA
ACTGTAAACAGTAATGGACGCCAAATTATAGGTAGCTGATTTTGCTGGAGAGTTTAATTACCTTGTGCAGTCAAAGAGCGCTTCCAGAAG
GAATCTCTTAAAACATAATGAGAGGTTTGGTAATGTGATATTTTAAGCTTATTCTTTTTCTTAAAAGAGAGAGGTGACGAAGGAAGGCAG
GAATGAAGAAGCACTGCGTGGCCTCCGGTGGAATGCACGGGGCACAGCCGCGACTCTGCAGGCAGCTTCCCCCCCATGCCAGGGCTCTGC
GCCGTCATGTGAGACTTAAAAAAAAAGTTGAATGACTTCGTGATACTTTGGACTTCTAAATTAAATTTATCAGGCATAAATTATGTAGAA
TTAGAGGCTTTGAAAATAATACTGGTAGGTTGCTCAAAGGTTTTGAAAGAGAAATCGCTAGGTAGGTTACTATCTGGCTAATCCATTTCT
TATCCTTGACAATTTAATTCATATTTGGGAAACTTTTAGGGAAATGAAAAATAAAAGTCACTGAGTCTGGGTGACATTTTTTAAGAATAA
TATAAATTCAGTTTCAAACTCTTCTCACATTAAAATTTTGCTGTGAACTCTTACTAAAATGAGTTTTAGGTTCTGTAAGTGGAAAAATGT
GCTTTTATTTTATGGGCCATTTTTACCACAACTAATCTTGCCTTGGATTACTAAGCATCTCCTGCGATCCCACAGAGGACTGTGGTGGCC
ACAGGAGCTGAAAGCAGAAGAGTGGGATTTGATGCCAGGCAGTGGAGTGGCCTCAGCCCCAGATTGTACCTCCTGCCCTGTAGGAGGGGA
GGGGGCAAAGCCTTCTGACTTCACCTTTGTTTGACCTATGTATGGAACTTACTTTTACTTTTTGCCTTAAATTTTTAATGAAATGCAAAT
TTTCTGTGATGGGGTTCTCTCTCTCTTTTTTTCGGGGGGTGGAGTCACTAATAAATTTGCAAATGAAGTTAAAGACAAGGCAACCATCTG
GCTTATGCTATATAATACTTCATTTAAAGAAGAAAGGAAAAGCAAATGCACTTGCAGCTTTTGAGGTCTCAGCAAAAATGGGCATGTGTC
TTTTTTGAAGTTTAGAAATATCCTAATCTATTTTTATTTATCTAAAAGTAAGTGTTTTCCGGCTGATAAGGCTAACCCTACCCAGGAAAG
GATTGATAACTAAATAAATTTCCTCTGTTTTCCCATGCATTGAAATTATGTTGGCTGAGCATGGTGGCTCACACCTGTAATCCTAGCACT
TTGGGAGGCCGAGGTGGGCGGATCACTTGAGGTCAGGAGTTGGAGACCAGCCTGGCCAACGTGGTGAATCCCCGTCTCTACTGAAAACAC
AAAAATTAGACGGGCATGGTGGCGCACACCTGTAATCCCAGCTACTTGGGAGGCTGAGGCAGGAGAATTGCTTGAACCTGGGAGGTGGAG
GTTGCAGTGAGCTAAAATTGTGCCACTGCACTCCAGCCTGGGTGACAGAGGAAGACTCCGTCTCACAAAAAAAAAAAAAGAAAAAAGAAA
TTATGCCAGCTGTTTAATGTGAGAGAATAGAAAGAATGTTCATGGAATGTACCTGCCCTGTAAAATGTTTGATCATTTTCATTAATGTTG
CAGAGAATCCGACTGCTATTAAGAGAAAGTGAACAAATTAAGAATTTAAAAGACAGGTTCAGGCATGTCATAAGTGAAAACAAGAAGGCT
TAATACAAACTTGTTGGGTTTTGTTCGTGTGTGTGTGTGTGTGTGTGTGTGTGTTTTTTTTTGGTTCAGCCTATCTAGCCACCTACAAAT
AATCACATTTCTGTTACCTGAATTTATTTCTCAGCCTGTAAACCTTAGTCACTGTTACCTGTTTCTTGCTCAGTGAATATGATCTTGGCA
CTGTCATCTAGAAAGCAAGATATTTGATTGGTTTTCTGGTTCCTTCGAAGATAATAATTCCATATCCAGTTTGACTGATTTTCATACCCC
TGAATCAACTAGTTATTTTCATGAAATGGTTTTTGGATATCTCTCCTCTAGTTTGGAGAAGTAATAATCACAAAGATTAATATTTTGCTT
CTAGTACTTACAGTAGAAGAATTTTAAACTGGTACGTCTACTCCTGTTAAATAGAAAGGGGATTCGTTGTATTATGTGCTTGCTTTTTTT
TAATCAATAGAATAAGATTCAATGCATATTTATGTTTTATATTTTCCACTATTCAGGTATCATGAAATCACTCTAGAGATGATCAATCAA
CATCATATTTATACTTTTGGTTAATTATATACTACTCAGGGAAAAAATGAACAAAAATAACTACTCATCCTTCAATTTCATTTTCTTGAA
ACAGTAAGAGTATAATTTGGTATGCCTCAGCTGTCACCATTTTATAAGTGGCTCATTCTGTTCTTAAAGTAAGTATTTTTATTGGAACTC
AGGGTAATTGGGGGAATTTATTTAGCTTCTAAAATATCCGGCAGGATAGAGAAGATTTATTTGGCTTCAAAAATGTCTGGTGACCACTTC
TCTTATTAGCCACTACTGCCCATTTGCTTCAAAAATATATTTATTGGTCTCCACCATGTGTGACACACACAGGATTTCCAAACATACCAC
TTTTGAGAAAAATGTGCAGTAAAAAGGAGGTTTCTAGAAAGTGACAGTAACTCACATTTAAGCACTAGCTGACCTAGGAGGAGACCTGGA
TCTTCATTCTGGTTCTGCCTTTCATGAGACTTAAGACTTGGAGGAGCCACCTGTCCTGTAGACCCCAAGTTCCTCAGCCATAAGCAAACG
GGTTAATCCTAAGAGTTCAGGACCAGTTGGGTGTCGTGAACGGAGCCATTAGCAAGGTCTGTAGGATTCAAGGACTTGGGCACATTCACA
GTCCACACTATTGTCATGGTCATTGACTTACTACTTGAGCTCAAAGCCCTGACATTTCAAAAGGTTGTCATGATAACAGTGAAACCTCTG
AATCCCTTAAATCAGAAGGCATGGCAACATACTTTTTCTACTGGCAATAGCTCTTACAATGAGTGTTTCATAATGAAATAGTCTCTGCTG
AAGAAAACATGTTTTCCTTTTGCTCTCTCTGCTTTGTTGGTTTCTGTGCTGTGTGGAATTGGAGAAGATATATGCTCTGAAATATTTTAT
ACAGATTACTGACTACTGGACAGGGTTTACCACTATATAACATCTCAAAGTTATTCAAGGATATTTAAAGCATATTTAGTTTAGTTACAC
CTTATTTTAAACCGCAGAAAACAATAGCTTTAAAATTTTTGCCATTAAAATAATTATAAATTTATACTTTTACTCAAGGACTAGATCACA
GTTTTAGGACAAAAATCTCTCCTATTTAAAGTTCATACCTTGTAAGTATTTAGTTTGTATATTCATGAACAAATCTGGACATTTATACTT
TTTTTGTTTCCTTATCAACTGTTCACAATTATTAGTTAATTGGTCTTAACAGTTCTACATTATAATTGAAAGAAAAATTACTTGAGAAAA
TAATTGTTTCAGAATAGTGCCTACTATATCTGTGTCAGCTAAAAATTTGTCCAGAGTTTTAGATATAAGCTAGTATTTTGTGGAGTTTTA
TCCAGGCGTTAATAGTTCTTCCTGGCTGAAATTTAATATAGGTGCAGAATCCTAAATAACACTGTGAGATGTAATCTTAACTGCCCTCAA
TACCTTATAAAACTGCTGCATTTAACCCAGTGTGCATTTAATGAGTGGCTGGTCGTTGATACACTCATCTTAGATGCTGAAATTTCTGTT
TTCTCCAGCCCTTGTAAAAGTGGGTTTCTTGATGAACGCGTGCTCCCAATGCTGAAGCAAAAGATTTGCATTTAAGGAGAGAAATACACC
CTGAAATTTGAGTTTGAAAGATTAGAACATAGAGGGTCTCTACAGTGTTTTTCTGCAACACCAAGTAGTCAAATCTATTTATAGAAACTC
TGATTACAACAGAAATTTTAAAATGAAATTTTCCACATCGGTATTTTGTAGGAAAGCTCTTATAATCAATGCTTAAGCTGCTTTTTGAGG
CTTTTCTTGTACAGAGGTTGCAGCCAATTACATTTTAATTGGTAGGCTGCTGAATAATGTTTTTGTATGTTTTAAAATAATATTTATTTT
AATAGGTTTTTTAACATTATGCAAATCCCAATAAAGAACTGACACGTTCCATAGGCCATTGACTGGGAAATTTTGTGAAACACAGCCTAA
ATACACAGTTTTTACACCAACTAATTTGTCTTGCCTTTAAAACTGATTATAACTCTTCTTTAAGTACAACTTTTATAAAGAAAAAATACA
ACACTAAGACTGTATGTTCTGTAAATTATAGTGTGATGACCCATGCAGAACCGCTGTCTGAAGCTTACTCAGCGATTCATAGCCATCTCC
AGCCATGTTTTATCAAATCACACACTAAAAATAAATGGAAATGCTACAGTGAAAAACCAAAAGTTACAGAGCAACATAAGTAAAATGACT
AGGCAGTTTCTTAGTAACATGTTTGAAATGGGAAAGGTGACTGACTGCCTTTCACCAGAGTCTTAGCTGTTTCACGTTCACTATTTTAGG
TTAATTTTCTTGGGAAATCAATTTGAATATTCCCCCCTGTCCTTTTGCATTAAAGGACGAAAATATATGTTGAGAGTTTGACAGACTTTT
TAAATATGCCTCTTTCCCAATTTTATGTATTTTTGGTTCTGCGCACACAGATTTATCAATGAAGTACATTTGCCTCTGGCTTTATCACAA
GGAAAAAGGAATCAAACATTGAACACAAATGTGTTCCAAACCAGTCTTGTCCATCTTGTCACTTTTATGTGACTGCTCCTCTGAACCAGA
AGGGGCACGATAGAAGGCCATAGGAATGAAAGTAAATCATTCAGGTGAAGTGAGAAATTCTTCCATATACAGAGTGAAAATGTGTGATTT
CATTCCTGCCTTCCTTTAAACGTTGTCTTGATCTCTGCCTAGTAGTAGTTGAGCCCTCAGTCGCCCAAACATGAGGAGAGACCCAACTCC
AGCAGCCAGAATTTAGTATTTACATTTGCCTTCCCAAGTTGAGAATAGAATGTGGTGTTCTGTGCTTTCTGTTTTTATTATTCCAAAATA
TTTTTTTAAAGAAGTGTTATTTTTCAACAGATTCATAAATTAGTTCCTGATGTACGGTAAATTAAAACTCCCACTGTGTCAGTCAAACTG
AGATGTGCTCATTTCATAACCACTCATTTCTAGTCTGTCAGAGCTGCACTGGTGGCTTATTGCTGGTTTTTAAAGGTGTTTTTAACTTAC

>4197_4197_1_AMD1-MBOAT2_AMD1_chr6_111210186_ENST00000368876_MBOAT2_chr2_9004364_ENST00000305997_length(amino acids)=256AA_BP=64
MKDVQCSIISVTKTDKQEAYVLSESSMFVSKRRFILKTCGTTLLLKALVPLLKLARDYSGFDSIQMSTSFKMFLDNWNIQTALWLKRVCY
ERTSFSPTIQTFILSAIWHGVYPGYYLTFLTGVLMTLAARAMRNNFRHYFIEPSQLKLFYDVITWIVTQVAISYTVVPFVLLSIKPSLTF

--------------------------------------------------------------
>4197_4197_2_AMD1-MBOAT2_AMD1_chr6_111210186_ENST00000368877_MBOAT2_chr2_9004364_ENST00000305997_length(transcript)=7123nt_BP=558nt
GCTTACACAGTATGGCCGGCGACATTAGCTAGCGCTCGCTCTACTCTCTCTAACGGGAAAGCAGCGGAATACAAGAGACTGAACTGTATC
TGCCTCTATTTCCAAAAGACTCACGTTCAACTTTCGCTCACACAAAGCCGGGAAAATTTTATTAGTCCTTTTTTTAAAAAAAGTTAATAT
AAAATTATAGCAAAAAAAAAAAGGAACCTGAACTTTAGTAACACAGCTGGAACAATCCGCAGCGGCGGCGGCAGCGGCGGGAGAAGAGGT
TTAATTTAGTTGATTTTCTGTGGTTGTTGGTTGTTCGCTAGTCTCACGGTGATGGAAGCTGCACATTTTTTCGAAGGGACCGAGAAGCTG
CTGGAGGTTTGGTTCTCCCGGCAGCAGCCCGACGCAAACCAAGGATCTGGGGATCTTCGCACTATCCCAAGTGAGAGTAGCATGTTTGTC
TCCAAGAGACGTTTCATTTTGAAGACATGTGGTACCACCCTCTTGCTGAAAGCACTGGTTCCCCTGTTGAAGCTTGCTAGGGATTACAGT
GGGTTTGACTCAATTCAAATGTCAACAAGTTTCAAGATGTTTCTTGATAATTGGAATATTCAGACAGCTCTTTGGCTCAAAAGGGTGTGT
TATGAACGAACCTCCTTCAGTCCAACTATCCAGACGTTCATTCTCTCTGCCATTTGGCACGGGGTATACCCAGGATATTATCTAACGTTT
CTAACAGGGGTGTTAATGACATTAGCAGCAAGAGCTATGAGAAATAACTTTAGACATTATTTCATTGAACCTTCCCAACTGAAATTATTT
TATGATGTTATAACATGGATAGTAACTCAAGTAGCAATAAGTTACACAGTTGTGCCATTTGTGCTTCTTTCTATAAAACCATCACTCACG
TTTTACAGCTCCTGGTATTATTGCCTGCACATTCTTGGTATCTTAGTATTATTGTTGTTGCCAGTGAAAAAAACTCAAAGAAGAAAGAAT
ACACATGAAAACATTCAGCTCTCACAATCCAAAAAGTTTGATGAAGGAGAAAATTCTTTGGGACAGAACAGTTTTTCTACAACAAACAAT
GTTTGCAATCAGAATCAAGAAATAGCCTCGAGACATTCATCACTAAAGCAGTGATCGGGAAGGCTCTGAGGGCTGTTTTTTTTTTTTGAT
GTTAACAGAAACCAATCTTAGCACCTTTTCAAGGGGTTTGAGTTTGTTGGAAAAGCAGTTAACTGGGGGGAAATGGACAGTTATAGATAA
GGAATTTCCTGTACACCAGATTGGAAATGGAGTGAAACAAGCCCTCCCATGCCATGTCTCCGTGGGCCACGCCTTATGTAAGAATATTTC
CATATTTCAGTGGGCACTCCCAACCTCAGCACTTGTCCGTAGGGTCACACGCGTGCCCTGTTGCTGAATGTATGTTGCGTATCCCAAGGC
ACTGAAGAGGTGGAAAAATAATCGTGTCAATCTGGATGATAGAGAGAAATTAACTTTTCCAAATGAATGTCTTGCCTTAAACCCTCTATT
TCCTAAAATATTGTTCCTAAATGGTATTTTCAAGTGTAATATTGTGAGAACGCTACTGCAGTAGTTGATGTTGTGTGCTGTAAAGGATTT
TAGGAGGAATTTGAAACAGGATATTTAAGAGTGTGGATATTTTTAAAATGCAATAAACATCTCAGTATTTGAAGGGTTTTCTTAAAGTAT
GTCAAATGACTACAATCCATAGTGAAACTGTAAACAGTAATGGACGCCAAATTATAGGTAGCTGATTTTGCTGGAGAGTTTAATTACCTT
GTGCAGTCAAAGAGCGCTTCCAGAAGGAATCTCTTAAAACATAATGAGAGGTTTGGTAATGTGATATTTTAAGCTTATTCTTTTTCTTAA
AAGAGAGAGGTGACGAAGGAAGGCAGGAATGAAGAAGCACTGCGTGGCCTCCGGTGGAATGCACGGGGCACAGCCGCGACTCTGCAGGCA
GCTTCCCCCCCATGCCAGGGCTCTGCGCCGTCATGTGAGACTTAAAAAAAAAGTTGAATGACTTCGTGATACTTTGGACTTCTAAATTAA
ATTTATCAGGCATAAATTATGTAGAATTAGAGGCTTTGAAAATAATACTGGTAGGTTGCTCAAAGGTTTTGAAAGAGAAATCGCTAGGTA
GGTTACTATCTGGCTAATCCATTTCTTATCCTTGACAATTTAATTCATATTTGGGAAACTTTTAGGGAAATGAAAAATAAAAGTCACTGA
GTCTGGGTGACATTTTTTAAGAATAATATAAATTCAGTTTCAAACTCTTCTCACATTAAAATTTTGCTGTGAACTCTTACTAAAATGAGT
TTTAGGTTCTGTAAGTGGAAAAATGTGCTTTTATTTTATGGGCCATTTTTACCACAACTAATCTTGCCTTGGATTACTAAGCATCTCCTG
CGATCCCACAGAGGACTGTGGTGGCCACAGGAGCTGAAAGCAGAAGAGTGGGATTTGATGCCAGGCAGTGGAGTGGCCTCAGCCCCAGAT
TGTACCTCCTGCCCTGTAGGAGGGGAGGGGGCAAAGCCTTCTGACTTCACCTTTGTTTGACCTATGTATGGAACTTACTTTTACTTTTTG
CCTTAAATTTTTAATGAAATGCAAATTTTCTGTGATGGGGTTCTCTCTCTCTTTTTTTCGGGGGGTGGAGTCACTAATAAATTTGCAAAT
GAAGTTAAAGACAAGGCAACCATCTGGCTTATGCTATATAATACTTCATTTAAAGAAGAAAGGAAAAGCAAATGCACTTGCAGCTTTTGA
GGTCTCAGCAAAAATGGGCATGTGTCTTTTTTGAAGTTTAGAAATATCCTAATCTATTTTTATTTATCTAAAAGTAAGTGTTTTCCGGCT
GATAAGGCTAACCCTACCCAGGAAAGGATTGATAACTAAATAAATTTCCTCTGTTTTCCCATGCATTGAAATTATGTTGGCTGAGCATGG
TGGCTCACACCTGTAATCCTAGCACTTTGGGAGGCCGAGGTGGGCGGATCACTTGAGGTCAGGAGTTGGAGACCAGCCTGGCCAACGTGG
TGAATCCCCGTCTCTACTGAAAACACAAAAATTAGACGGGCATGGTGGCGCACACCTGTAATCCCAGCTACTTGGGAGGCTGAGGCAGGA
GAATTGCTTGAACCTGGGAGGTGGAGGTTGCAGTGAGCTAAAATTGTGCCACTGCACTCCAGCCTGGGTGACAGAGGAAGACTCCGTCTC
ACAAAAAAAAAAAAAGAAAAAAGAAATTATGCCAGCTGTTTAATGTGAGAGAATAGAAAGAATGTTCATGGAATGTACCTGCCCTGTAAA
ATGTTTGATCATTTTCATTAATGTTGCAGAGAATCCGACTGCTATTAAGAGAAAGTGAACAAATTAAGAATTTAAAAGACAGGTTCAGGC
ATGTCATAAGTGAAAACAAGAAGGCTTAATACAAACTTGTTGGGTTTTGTTCGTGTGTGTGTGTGTGTGTGTGTGTGTGTTTTTTTTTGG
TTCAGCCTATCTAGCCACCTACAAATAATCACATTTCTGTTACCTGAATTTATTTCTCAGCCTGTAAACCTTAGTCACTGTTACCTGTTT
CTTGCTCAGTGAATATGATCTTGGCACTGTCATCTAGAAAGCAAGATATTTGATTGGTTTTCTGGTTCCTTCGAAGATAATAATTCCATA
TCCAGTTTGACTGATTTTCATACCCCTGAATCAACTAGTTATTTTCATGAAATGGTTTTTGGATATCTCTCCTCTAGTTTGGAGAAGTAA
TAATCACAAAGATTAATATTTTGCTTCTAGTACTTACAGTAGAAGAATTTTAAACTGGTACGTCTACTCCTGTTAAATAGAAAGGGGATT
CGTTGTATTATGTGCTTGCTTTTTTTTAATCAATAGAATAAGATTCAATGCATATTTATGTTTTATATTTTCCACTATTCAGGTATCATG
AAATCACTCTAGAGATGATCAATCAACATCATATTTATACTTTTGGTTAATTATATACTACTCAGGGAAAAAATGAACAAAAATAACTAC
TCATCCTTCAATTTCATTTTCTTGAAACAGTAAGAGTATAATTTGGTATGCCTCAGCTGTCACCATTTTATAAGTGGCTCATTCTGTTCT
TAAAGTAAGTATTTTTATTGGAACTCAGGGTAATTGGGGGAATTTATTTAGCTTCTAAAATATCCGGCAGGATAGAGAAGATTTATTTGG
CTTCAAAAATGTCTGGTGACCACTTCTCTTATTAGCCACTACTGCCCATTTGCTTCAAAAATATATTTATTGGTCTCCACCATGTGTGAC
ACACACAGGATTTCCAAACATACCACTTTTGAGAAAAATGTGCAGTAAAAAGGAGGTTTCTAGAAAGTGACAGTAACTCACATTTAAGCA
CTAGCTGACCTAGGAGGAGACCTGGATCTTCATTCTGGTTCTGCCTTTCATGAGACTTAAGACTTGGAGGAGCCACCTGTCCTGTAGACC
CCAAGTTCCTCAGCCATAAGCAAACGGGTTAATCCTAAGAGTTCAGGACCAGTTGGGTGTCGTGAACGGAGCCATTAGCAAGGTCTGTAG
GATTCAAGGACTTGGGCACATTCACAGTCCACACTATTGTCATGGTCATTGACTTACTACTTGAGCTCAAAGCCCTGACATTTCAAAAGG
TTGTCATGATAACAGTGAAACCTCTGAATCCCTTAAATCAGAAGGCATGGCAACATACTTTTTCTACTGGCAATAGCTCTTACAATGAGT
GTTTCATAATGAAATAGTCTCTGCTGAAGAAAACATGTTTTCCTTTTGCTCTCTCTGCTTTGTTGGTTTCTGTGCTGTGTGGAATTGGAG
AAGATATATGCTCTGAAATATTTTATACAGATTACTGACTACTGGACAGGGTTTACCACTATATAACATCTCAAAGTTATTCAAGGATAT
TTAAAGCATATTTAGTTTAGTTACACCTTATTTTAAACCGCAGAAAACAATAGCTTTAAAATTTTTGCCATTAAAATAATTATAAATTTA
TACTTTTACTCAAGGACTAGATCACAGTTTTAGGACAAAAATCTCTCCTATTTAAAGTTCATACCTTGTAAGTATTTAGTTTGTATATTC
ATGAACAAATCTGGACATTTATACTTTTTTTGTTTCCTTATCAACTGTTCACAATTATTAGTTAATTGGTCTTAACAGTTCTACATTATA
ATTGAAAGAAAAATTACTTGAGAAAATAATTGTTTCAGAATAGTGCCTACTATATCTGTGTCAGCTAAAAATTTGTCCAGAGTTTTAGAT
ATAAGCTAGTATTTTGTGGAGTTTTATCCAGGCGTTAATAGTTCTTCCTGGCTGAAATTTAATATAGGTGCAGAATCCTAAATAACACTG
TGAGATGTAATCTTAACTGCCCTCAATACCTTATAAAACTGCTGCATTTAACCCAGTGTGCATTTAATGAGTGGCTGGTCGTTGATACAC
TCATCTTAGATGCTGAAATTTCTGTTTTCTCCAGCCCTTGTAAAAGTGGGTTTCTTGATGAACGCGTGCTCCCAATGCTGAAGCAAAAGA
TTTGCATTTAAGGAGAGAAATACACCCTGAAATTTGAGTTTGAAAGATTAGAACATAGAGGGTCTCTACAGTGTTTTTCTGCAACACCAA
GTAGTCAAATCTATTTATAGAAACTCTGATTACAACAGAAATTTTAAAATGAAATTTTCCACATCGGTATTTTGTAGGAAAGCTCTTATA
ATCAATGCTTAAGCTGCTTTTTGAGGCTTTTCTTGTACAGAGGTTGCAGCCAATTACATTTTAATTGGTAGGCTGCTGAATAATGTTTTT
GTATGTTTTAAAATAATATTTATTTTAATAGGTTTTTTAACATTATGCAAATCCCAATAAAGAACTGACACGTTCCATAGGCCATTGACT
GGGAAATTTTGTGAAACACAGCCTAAATACACAGTTTTTACACCAACTAATTTGTCTTGCCTTTAAAACTGATTATAACTCTTCTTTAAG
TACAACTTTTATAAAGAAAAAATACAACACTAAGACTGTATGTTCTGTAAATTATAGTGTGATGACCCATGCAGAACCGCTGTCTGAAGC
TTACTCAGCGATTCATAGCCATCTCCAGCCATGTTTTATCAAATCACACACTAAAAATAAATGGAAATGCTACAGTGAAAAACCAAAAGT
TACAGAGCAACATAAGTAAAATGACTAGGCAGTTTCTTAGTAACATGTTTGAAATGGGAAAGGTGACTGACTGCCTTTCACCAGAGTCTT
AGCTGTTTCACGTTCACTATTTTAGGTTAATTTTCTTGGGAAATCAATTTGAATATTCCCCCCTGTCCTTTTGCATTAAAGGACGAAAAT
ATATGTTGAGAGTTTGACAGACTTTTTAAATATGCCTCTTTCCCAATTTTATGTATTTTTGGTTCTGCGCACACAGATTTATCAATGAAG
TACATTTGCCTCTGGCTTTATCACAAGGAAAAAGGAATCAAACATTGAACACAAATGTGTTCCAAACCAGTCTTGTCCATCTTGTCACTT
TTATGTGACTGCTCCTCTGAACCAGAAGGGGCACGATAGAAGGCCATAGGAATGAAAGTAAATCATTCAGGTGAAGTGAGAAATTCTTCC
ATATACAGAGTGAAAATGTGTGATTTCATTCCTGCCTTCCTTTAAACGTTGTCTTGATCTCTGCCTAGTAGTAGTTGAGCCCTCAGTCGC
CCAAACATGAGGAGAGACCCAACTCCAGCAGCCAGAATTTAGTATTTACATTTGCCTTCCCAAGTTGAGAATAGAATGTGGTGTTCTGTG
CTTTCTGTTTTTATTATTCCAAAATATTTTTTTAAAGAAGTGTTATTTTTCAACAGATTCATAAATTAGTTCCTGATGTACGGTAAATTA
AAACTCCCACTGTGTCAGTCAAACTGAGATGTGCTCATTTCATAACCACTCATTTCTAGTCTGTCAGAGCTGCACTGGTGGCTTATTGCT
GGTTTTTAAAGGTGTTTTTAACTTACATGTAACATGTTTAGGACATGTTTTTTTTTTCTAATTTGTGTGTCTTTACAACTGATTAAACAG

>4197_4197_2_AMD1-MBOAT2_AMD1_chr6_111210186_ENST00000368877_MBOAT2_chr2_9004364_ENST00000305997_length(amino acids)=284AA_BP=92
MIFCGCWLFASLTVMEAAHFFEGTEKLLEVWFSRQQPDANQGSGDLRTIPSESSMFVSKRRFILKTCGTTLLLKALVPLLKLARDYSGFD
SIQMSTSFKMFLDNWNIQTALWLKRVCYERTSFSPTIQTFILSAIWHGVYPGYYLTFLTGVLMTLAARAMRNNFRHYFIEPSQLKLFYDV
ITWIVTQVAISYTVVPFVLLSIKPSLTFYSSWYYCLHILGILVLLLLPVKKTQRRKNTHENIQLSQSKKFDEGENSLGQNSFSTTNNVCN

--------------------------------------------------------------
>4197_4197_3_AMD1-MBOAT2_AMD1_chr6_111210186_ENST00000368885_MBOAT2_chr2_9004364_ENST00000305997_length(transcript)=7225nt_BP=660nt
TCACGCAGCGCTCTCGCTTACACAGTATGGCCGGCGACATTAGCTAGCGCTCGCTCTACTCTCTCTAACGGGAAAGCAGCGGAATACAAG
AGACTGAACTGTATCTGCCTCTATTTCCAAAAGACTCACGTTCAACTTTCGCTCACACAAAGCCGGGAAAATTTTATTAGTCCTTTTTTT
AAAAAAAGTTAATATAAAATTATAGCAAAAAAAAAAAGGAACCTGAACTTTAGTAACACAGCTGGAACAATCCGCAGCGGCGGCGGCAGC
GGCGGGAGAAGAGGTTTAATTTAGTTGATTTTCTGTGGTTGTTGGTTGTTCGCTAGTCTCACGGTGATGGAAGCTGCACATTTTTTCGAA
GGGACCGAGAAGCTGCTGGAGGTTTGGTTCTCCCGGCAGCAGCCCGACGCAAACCAAGGATCTGGGGATCTTCGCACTATCCCAAGATCT
GAGTGGGACATACTTTTGAAGGATGTGCAATGTTCAATCATAAGTGTGACAAAAACTGACAAGCAGGAAGCTTATGTACTCAGTGAGAGT
AGCATGTTTGTCTCCAAGAGACGTTTCATTTTGAAGACATGTGGTACCACCCTCTTGCTGAAAGCACTGGTTCCCCTGTTGAAGCTTGCT
AGGGATTACAGTGGGTTTGACTCAATTCAAATGTCAACAAGTTTCAAGATGTTTCTTGATAATTGGAATATTCAGACAGCTCTTTGGCTC
AAAAGGGTGTGTTATGAACGAACCTCCTTCAGTCCAACTATCCAGACGTTCATTCTCTCTGCCATTTGGCACGGGGTATACCCAGGATAT
TATCTAACGTTTCTAACAGGGGTGTTAATGACATTAGCAGCAAGAGCTATGAGAAATAACTTTAGACATTATTTCATTGAACCTTCCCAA
CTGAAATTATTTTATGATGTTATAACATGGATAGTAACTCAAGTAGCAATAAGTTACACAGTTGTGCCATTTGTGCTTCTTTCTATAAAA
CCATCACTCACGTTTTACAGCTCCTGGTATTATTGCCTGCACATTCTTGGTATCTTAGTATTATTGTTGTTGCCAGTGAAAAAAACTCAA
AGAAGAAAGAATACACATGAAAACATTCAGCTCTCACAATCCAAAAAGTTTGATGAAGGAGAAAATTCTTTGGGACAGAACAGTTTTTCT
ACAACAAACAATGTTTGCAATCAGAATCAAGAAATAGCCTCGAGACATTCATCACTAAAGCAGTGATCGGGAAGGCTCTGAGGGCTGTTT
TTTTTTTTTGATGTTAACAGAAACCAATCTTAGCACCTTTTCAAGGGGTTTGAGTTTGTTGGAAAAGCAGTTAACTGGGGGGAAATGGAC
AGTTATAGATAAGGAATTTCCTGTACACCAGATTGGAAATGGAGTGAAACAAGCCCTCCCATGCCATGTCTCCGTGGGCCACGCCTTATG
TAAGAATATTTCCATATTTCAGTGGGCACTCCCAACCTCAGCACTTGTCCGTAGGGTCACACGCGTGCCCTGTTGCTGAATGTATGTTGC
GTATCCCAAGGCACTGAAGAGGTGGAAAAATAATCGTGTCAATCTGGATGATAGAGAGAAATTAACTTTTCCAAATGAATGTCTTGCCTT
AAACCCTCTATTTCCTAAAATATTGTTCCTAAATGGTATTTTCAAGTGTAATATTGTGAGAACGCTACTGCAGTAGTTGATGTTGTGTGC
TGTAAAGGATTTTAGGAGGAATTTGAAACAGGATATTTAAGAGTGTGGATATTTTTAAAATGCAATAAACATCTCAGTATTTGAAGGGTT
TTCTTAAAGTATGTCAAATGACTACAATCCATAGTGAAACTGTAAACAGTAATGGACGCCAAATTATAGGTAGCTGATTTTGCTGGAGAG
TTTAATTACCTTGTGCAGTCAAAGAGCGCTTCCAGAAGGAATCTCTTAAAACATAATGAGAGGTTTGGTAATGTGATATTTTAAGCTTAT
TCTTTTTCTTAAAAGAGAGAGGTGACGAAGGAAGGCAGGAATGAAGAAGCACTGCGTGGCCTCCGGTGGAATGCACGGGGCACAGCCGCG
ACTCTGCAGGCAGCTTCCCCCCCATGCCAGGGCTCTGCGCCGTCATGTGAGACTTAAAAAAAAAGTTGAATGACTTCGTGATACTTTGGA
CTTCTAAATTAAATTTATCAGGCATAAATTATGTAGAATTAGAGGCTTTGAAAATAATACTGGTAGGTTGCTCAAAGGTTTTGAAAGAGA
AATCGCTAGGTAGGTTACTATCTGGCTAATCCATTTCTTATCCTTGACAATTTAATTCATATTTGGGAAACTTTTAGGGAAATGAAAAAT
AAAAGTCACTGAGTCTGGGTGACATTTTTTAAGAATAATATAAATTCAGTTTCAAACTCTTCTCACATTAAAATTTTGCTGTGAACTCTT
ACTAAAATGAGTTTTAGGTTCTGTAAGTGGAAAAATGTGCTTTTATTTTATGGGCCATTTTTACCACAACTAATCTTGCCTTGGATTACT
AAGCATCTCCTGCGATCCCACAGAGGACTGTGGTGGCCACAGGAGCTGAAAGCAGAAGAGTGGGATTTGATGCCAGGCAGTGGAGTGGCC
TCAGCCCCAGATTGTACCTCCTGCCCTGTAGGAGGGGAGGGGGCAAAGCCTTCTGACTTCACCTTTGTTTGACCTATGTATGGAACTTAC
TTTTACTTTTTGCCTTAAATTTTTAATGAAATGCAAATTTTCTGTGATGGGGTTCTCTCTCTCTTTTTTTCGGGGGGTGGAGTCACTAAT
AAATTTGCAAATGAAGTTAAAGACAAGGCAACCATCTGGCTTATGCTATATAATACTTCATTTAAAGAAGAAAGGAAAAGCAAATGCACT
TGCAGCTTTTGAGGTCTCAGCAAAAATGGGCATGTGTCTTTTTTGAAGTTTAGAAATATCCTAATCTATTTTTATTTATCTAAAAGTAAG
TGTTTTCCGGCTGATAAGGCTAACCCTACCCAGGAAAGGATTGATAACTAAATAAATTTCCTCTGTTTTCCCATGCATTGAAATTATGTT
GGCTGAGCATGGTGGCTCACACCTGTAATCCTAGCACTTTGGGAGGCCGAGGTGGGCGGATCACTTGAGGTCAGGAGTTGGAGACCAGCC
TGGCCAACGTGGTGAATCCCCGTCTCTACTGAAAACACAAAAATTAGACGGGCATGGTGGCGCACACCTGTAATCCCAGCTACTTGGGAG
GCTGAGGCAGGAGAATTGCTTGAACCTGGGAGGTGGAGGTTGCAGTGAGCTAAAATTGTGCCACTGCACTCCAGCCTGGGTGACAGAGGA
AGACTCCGTCTCACAAAAAAAAAAAAAGAAAAAAGAAATTATGCCAGCTGTTTAATGTGAGAGAATAGAAAGAATGTTCATGGAATGTAC
CTGCCCTGTAAAATGTTTGATCATTTTCATTAATGTTGCAGAGAATCCGACTGCTATTAAGAGAAAGTGAACAAATTAAGAATTTAAAAG
ACAGGTTCAGGCATGTCATAAGTGAAAACAAGAAGGCTTAATACAAACTTGTTGGGTTTTGTTCGTGTGTGTGTGTGTGTGTGTGTGTGT
GTTTTTTTTTGGTTCAGCCTATCTAGCCACCTACAAATAATCACATTTCTGTTACCTGAATTTATTTCTCAGCCTGTAAACCTTAGTCAC
TGTTACCTGTTTCTTGCTCAGTGAATATGATCTTGGCACTGTCATCTAGAAAGCAAGATATTTGATTGGTTTTCTGGTTCCTTCGAAGAT
AATAATTCCATATCCAGTTTGACTGATTTTCATACCCCTGAATCAACTAGTTATTTTCATGAAATGGTTTTTGGATATCTCTCCTCTAGT
TTGGAGAAGTAATAATCACAAAGATTAATATTTTGCTTCTAGTACTTACAGTAGAAGAATTTTAAACTGGTACGTCTACTCCTGTTAAAT
AGAAAGGGGATTCGTTGTATTATGTGCTTGCTTTTTTTTAATCAATAGAATAAGATTCAATGCATATTTATGTTTTATATTTTCCACTAT
TCAGGTATCATGAAATCACTCTAGAGATGATCAATCAACATCATATTTATACTTTTGGTTAATTATATACTACTCAGGGAAAAAATGAAC
AAAAATAACTACTCATCCTTCAATTTCATTTTCTTGAAACAGTAAGAGTATAATTTGGTATGCCTCAGCTGTCACCATTTTATAAGTGGC
TCATTCTGTTCTTAAAGTAAGTATTTTTATTGGAACTCAGGGTAATTGGGGGAATTTATTTAGCTTCTAAAATATCCGGCAGGATAGAGA
AGATTTATTTGGCTTCAAAAATGTCTGGTGACCACTTCTCTTATTAGCCACTACTGCCCATTTGCTTCAAAAATATATTTATTGGTCTCC
ACCATGTGTGACACACACAGGATTTCCAAACATACCACTTTTGAGAAAAATGTGCAGTAAAAAGGAGGTTTCTAGAAAGTGACAGTAACT
CACATTTAAGCACTAGCTGACCTAGGAGGAGACCTGGATCTTCATTCTGGTTCTGCCTTTCATGAGACTTAAGACTTGGAGGAGCCACCT
GTCCTGTAGACCCCAAGTTCCTCAGCCATAAGCAAACGGGTTAATCCTAAGAGTTCAGGACCAGTTGGGTGTCGTGAACGGAGCCATTAG
CAAGGTCTGTAGGATTCAAGGACTTGGGCACATTCACAGTCCACACTATTGTCATGGTCATTGACTTACTACTTGAGCTCAAAGCCCTGA
CATTTCAAAAGGTTGTCATGATAACAGTGAAACCTCTGAATCCCTTAAATCAGAAGGCATGGCAACATACTTTTTCTACTGGCAATAGCT
CTTACAATGAGTGTTTCATAATGAAATAGTCTCTGCTGAAGAAAACATGTTTTCCTTTTGCTCTCTCTGCTTTGTTGGTTTCTGTGCTGT
GTGGAATTGGAGAAGATATATGCTCTGAAATATTTTATACAGATTACTGACTACTGGACAGGGTTTACCACTATATAACATCTCAAAGTT
ATTCAAGGATATTTAAAGCATATTTAGTTTAGTTACACCTTATTTTAAACCGCAGAAAACAATAGCTTTAAAATTTTTGCCATTAAAATA
ATTATAAATTTATACTTTTACTCAAGGACTAGATCACAGTTTTAGGACAAAAATCTCTCCTATTTAAAGTTCATACCTTGTAAGTATTTA
GTTTGTATATTCATGAACAAATCTGGACATTTATACTTTTTTTGTTTCCTTATCAACTGTTCACAATTATTAGTTAATTGGTCTTAACAG
TTCTACATTATAATTGAAAGAAAAATTACTTGAGAAAATAATTGTTTCAGAATAGTGCCTACTATATCTGTGTCAGCTAAAAATTTGTCC
AGAGTTTTAGATATAAGCTAGTATTTTGTGGAGTTTTATCCAGGCGTTAATAGTTCTTCCTGGCTGAAATTTAATATAGGTGCAGAATCC
TAAATAACACTGTGAGATGTAATCTTAACTGCCCTCAATACCTTATAAAACTGCTGCATTTAACCCAGTGTGCATTTAATGAGTGGCTGG
TCGTTGATACACTCATCTTAGATGCTGAAATTTCTGTTTTCTCCAGCCCTTGTAAAAGTGGGTTTCTTGATGAACGCGTGCTCCCAATGC
TGAAGCAAAAGATTTGCATTTAAGGAGAGAAATACACCCTGAAATTTGAGTTTGAAAGATTAGAACATAGAGGGTCTCTACAGTGTTTTT
CTGCAACACCAAGTAGTCAAATCTATTTATAGAAACTCTGATTACAACAGAAATTTTAAAATGAAATTTTCCACATCGGTATTTTGTAGG
AAAGCTCTTATAATCAATGCTTAAGCTGCTTTTTGAGGCTTTTCTTGTACAGAGGTTGCAGCCAATTACATTTTAATTGGTAGGCTGCTG
AATAATGTTTTTGTATGTTTTAAAATAATATTTATTTTAATAGGTTTTTTAACATTATGCAAATCCCAATAAAGAACTGACACGTTCCAT
AGGCCATTGACTGGGAAATTTTGTGAAACACAGCCTAAATACACAGTTTTTACACCAACTAATTTGTCTTGCCTTTAAAACTGATTATAA
CTCTTCTTTAAGTACAACTTTTATAAAGAAAAAATACAACACTAAGACTGTATGTTCTGTAAATTATAGTGTGATGACCCATGCAGAACC
GCTGTCTGAAGCTTACTCAGCGATTCATAGCCATCTCCAGCCATGTTTTATCAAATCACACACTAAAAATAAATGGAAATGCTACAGTGA
AAAACCAAAAGTTACAGAGCAACATAAGTAAAATGACTAGGCAGTTTCTTAGTAACATGTTTGAAATGGGAAAGGTGACTGACTGCCTTT
CACCAGAGTCTTAGCTGTTTCACGTTCACTATTTTAGGTTAATTTTCTTGGGAAATCAATTTGAATATTCCCCCCTGTCCTTTTGCATTA
AAGGACGAAAATATATGTTGAGAGTTTGACAGACTTTTTAAATATGCCTCTTTCCCAATTTTATGTATTTTTGGTTCTGCGCACACAGAT
TTATCAATGAAGTACATTTGCCTCTGGCTTTATCACAAGGAAAAAGGAATCAAACATTGAACACAAATGTGTTCCAAACCAGTCTTGTCC
ATCTTGTCACTTTTATGTGACTGCTCCTCTGAACCAGAAGGGGCACGATAGAAGGCCATAGGAATGAAAGTAAATCATTCAGGTGAAGTG
AGAAATTCTTCCATATACAGAGTGAAAATGTGTGATTTCATTCCTGCCTTCCTTTAAACGTTGTCTTGATCTCTGCCTAGTAGTAGTTGA
GCCCTCAGTCGCCCAAACATGAGGAGAGACCCAACTCCAGCAGCCAGAATTTAGTATTTACATTTGCCTTCCCAAGTTGAGAATAGAATG
TGGTGTTCTGTGCTTTCTGTTTTTATTATTCCAAAATATTTTTTTAAAGAAGTGTTATTTTTCAACAGATTCATAAATTAGTTCCTGATG
TACGGTAAATTAAAACTCCCACTGTGTCAGTCAAACTGAGATGTGCTCATTTCATAACCACTCATTTCTAGTCTGTCAGAGCTGCACTGG
TGGCTTATTGCTGGTTTTTAAAGGTGTTTTTAACTTACATGTAACATGTTTAGGACATGTTTTTTTTTTCTAATTTGTGTGTCTTTACAA

>4197_4197_3_AMD1-MBOAT2_AMD1_chr6_111210186_ENST00000368885_MBOAT2_chr2_9004364_ENST00000305997_length(amino acids)=313AA_BP=121
MIFCGCWLFASLTVMEAAHFFEGTEKLLEVWFSRQQPDANQGSGDLRTIPRSEWDILLKDVQCSIISVTKTDKQEAYVLSESSMFVSKRR
FILKTCGTTLLLKALVPLLKLARDYSGFDSIQMSTSFKMFLDNWNIQTALWLKRVCYERTSFSPTIQTFILSAIWHGVYPGYYLTFLTGV
LMTLAARAMRNNFRHYFIEPSQLKLFYDVITWIVTQVAISYTVVPFVLLSIKPSLTFYSSWYYCLHILGILVLLLLPVKKTQRRKNTHEN

--------------------------------------------------------------

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Fusion Gene PPI Analysis for AMD1-MBOAT2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for AMD1-MBOAT2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for AMD1-MBOAT2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneC0019209Hepatomegaly1CTD_human